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Dietary restriction during active cancer therapy is associated with improved treatment response:a systematic review and meta-analysis 认领 引用
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作者 Kajal Agrawal Dominic Shao Yong Goh +8 位作者 Ee Chern Ng Shyn Yi Tan Carlos Cifuentes-González Jason Xing Kang William K.K.Wu Rashid N.S.Lui Rupesh Agrawal Yusuf Ali Sunny H.Wong 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第8期1193-1197,I0020-I0022,共5页
Cancer remains a leading cause of death worldwide,despite advances in surgery,chemotherapy,radiotherapy,and immunotherapy1.Challenges,like treatment-related toxicities and resistance,limit the overall benefits of curr... Cancer remains a leading cause of death worldwide,despite advances in surgery,chemotherapy,radiotherapy,and immunotherapy1.Challenges,like treatment-related toxicities and resistance,limit the overall benefits of current cancer therapies,leading to increased interest in supportive strategies that can boost treatment effectiveness while maintaining tolerability.Dietary restrictions,including calorie restriction(CR),a fasting-mimicking diet(FMD),and short-term fasting(STF),are emerging as promising adjuncts in cancer treatment by modulating tumour metabolism and the body’s stress-response pathways2.CR is defined as a sustained reduction in daily caloric intake(typically 20%–40%).A FMD is defined as a low-calorie,low-protein,low-carbohydrate dietary regimen administered over 3–5 d per cycle.STF is defined as complete or near-complete fasting lasting 24–72 h surrounding therapy.Cancer cells undergo significant metabolic reprogramming,primarily relying on aerobic glycolysis and growth factor signalling,a phenomenon known as the Warburg effect.This dependency makes malignant cells highly vulnerable to disruptions in the nutrient supply. 展开更多
关键词 fasting mimicking diet treatment response short term fasting calorie restriction cr supportive strategies calorie restriction cancer therapy dietary restriction
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Thallium(Ⅰ)retention in porous media is restricted by elevated Mn(Ⅱ)and Fe(Ⅲ)loadings:Insights into suitability between media and microbial communities 认领 引用
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作者 Yuheng Huang Xiaoling Zhang +3 位作者 Ziqiang Liu Xiaoliu Huangfu Qiang He Suyan Pang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第6期665-675,共11页
In tailings permeated by leachate containing thallium(Tl),manganese oxides(MnO x)are recognized as critical substances in immobilizing Tl and preventing its further migration into groundwater.However,dissolved Mn(... In tailings permeated by leachate containing thallium(Tl),manganese oxides(MnO x)are recognized as critical substances in immobilizing Tl and preventing its further migration into groundwater.However,dissolved Mn(Ⅱ)and Fe(Ⅲ)also exist in micro-oxic environments.The effects and mechanisms of the increased levels of these coexisting ions,driven by environmental processes such as rainfall leaching,on Tl(Ⅰ)retention remain largely unclear.This study established two systems using natural manganese sand and limestone sand as porous media,demonstrating that the elevated Mn(Ⅱ)/Fe(Ⅲ)loadings weakened Tl(Ⅰ)retention.Redundancy analysis identified media type and depth as primary factors shaping microbial communities,which subsequently influenced Tl(Ⅰ)immobilization.Manganese sand exhibited superior recovery capacity compared to limestone sand under higher Mn(Ⅱ)and Fe(Ⅲ)loadings.Co-occurrence network analyses revealed that media-microorganism suitability governs microbial community structure and heavy metal retention efficiency.Hydraulic impact and dissolved organic/inorganic cations reduced MnO x content,while the higher retention capacity of manganese sand was attributed to the presence of microorganisms with higher activity and abundance,as well as an increased abundance of microbial-generated MnO_( x).This study offers novel insights into the mechanisms underlying Tl(Ⅰ)retention in tailings,which is crucial for comprehending its environmental fate. 展开更多
关键词 Thallium Restricted retention Porous media Elevated loadings Co-occurrence network
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“CLINICAL-BFR”:An exploratory blood flow restriction protocol focusing on clinical application 认领 引用
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作者 Fabricio Eduardo Rossi Kassiana de Araújo Pessôa +9 位作者 Zhi Xia Jakob Lauver Daniel Newmire Jason Michael Cholewa Steven Machek Mario Alves de Siqueira Filho Fabio Santos Lira Antonio Herbert Lancha-Jr Emilia Zawieja Nelo Eidy Zanchi 《Sports Medicine and Health Science》 CAS CSCD 2026年第5期583-592,共10页
Purpose:Traditional blood flow restriction resistance training(BFR-Trad)is a cost-effective and time-efficient exercise modality that offers significant skeletal muscle benefits,including strength and mass gains.Despi... Purpose:Traditional blood flow restriction resistance training(BFR-Trad)is a cost-effective and time-efficient exercise modality that offers significant skeletal muscle benefits,including strength and mass gains.Despite employing low loads,BFR-Trad may not be well tolerated by all populations due to its high intensity,painassociated muscle discomfort,low affectivity,and cardiovascular responses.Consequently,reducing BFR intensity may be an interesting approach to making traditional BFR more clinically applicable.This was approached through the proposal of the present Clinical BFR.Methods:Twenty-two healthy,untrained subjects(both female and male)aged between 18 and 30 years participated.Subjects completed three sessions of unilateral knee extension exercises randomly assigned to the BFR-Trad,BFR-Clinical_c(cadenced),and BFR-Clinical_a(-autoregulated)exercise protocols.Results:The BFR-Trad condition induced greater increases in perceived exertion,discomfort,delayed onset muscle soreness(DOMS),and lactate levels compared to the BFR-Clinical conditions(p<0.05).Muscle concentric velocity showed greater increases in the BFR-Clinical_a condition(p<0.001),along with higher affectivity ratings for the exercise compared to the BFR-Clinical_c and BFR-Trad conditions(p<0.05).Conclusion:Compared to traditional BFR,clinical BFR was scored as less intense,reduced pain-associated discomfort,decreased DOMS,increased affectivity,diminished systolic blood pressure responses,decreased fatigue and muscle activation,and promoted similar glycemic responses.Altogether,our results support the potential use of clinical BFR in clinical settings. 展开更多
关键词 Resistance training Blood flow restriction Muscle power Discomfort Muscle fatigue
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Topology of the d-dimensional charged AdS black holes with a cloud of strings and quintessence in restricted phase space 认领 引用
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作者 Shan-Xia Bao Zhen-Ju Wan Yun-Zhi Du 《Communications in Theoretical Physics》 SCIE CAS CSCD 2026年第1期112-125,共14页
Based on the idea of treating the anti de Sitter(AdS)radius as a fixed parameter,we study the thermodynamics and topology of d-dimensional charged AdS black holes in the restricted phase space utilizing Visser’s holo... Based on the idea of treating the anti de Sitter(AdS)radius as a fixed parameter,we study the thermodynamics and topology of d-dimensional charged AdS black holes in the restricted phase space utilizing Visser’s holographic approach.For the charged black hole with a cloud of strings and quintessence in the higher-dimensional spacetimes with d=(4,5,6),we demonstrate that the topological number remains invariant within the same canonical ensemble;however,a distinct topological number emerges in the grand canonical ensemble for the same black hole system.Notably,these results are independent of the dimension d and other related parameters.The formalism known as restricted phase space thermodynamics is checked in detail and some interesting thermodynamic behavior is revealed in the example case of d-dimensional charged AdS black holes with a cloud of strings and quintessence.This research lays the foundation for establishing a universal framework of restricted phase space thermodynamics and investigating its fundamental thermodynamic properties. 展开更多
关键词 topology charged AdS black hole restricted phase space
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Open-label randomized controlled study of salt-restricted vs saltunrestricted diet in patients with cirrhosis with hyponatremia 认领 引用 被引量：1
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作者 Sudheer Marrapu Ramesh Kumar +4 位作者 Divendu Bhushan Sudhir Kumar Abhishek Kumar Rajeev N Priyadarshi Utpal Anand 《World Journal of Methodology》 2026年第2期146-156,共11页
BACKGROUND Salt restriction is commonly recommended for patients with cirrhosis to manage ascites;however,its safety and efficacy in patients with hyponatremia remain unclear.AIM To evaluate the effects of a salt-rest... BACKGROUND Salt restriction is commonly recommended for patients with cirrhosis to manage ascites;however,its safety and efficacy in patients with hyponatremia remain unclear.AIM To evaluate the effects of a salt-restricted diet(SRD;5 g/day)vs a salt-unrestricted diet(SUD;10 g/day)on renal,nutritional,and hemodynamic outcomes,as well as short-term mortality in patients with cirrhosis with moderate to severe hyponatremia.METHODS A total of 150 patients with serum sodium<130 mEq/L were randomized to either SRD or SUD.After excluding patients who died,were non-adherent,or were lost to follow-up within 4 weeks,105 participants(SRD:51;SUD:54)were included in the outcomes analysis.The primary outcome was the incidence of acute kidney injury(AKI)over 6 months;secondary outcomes included ascites control,nutritional markers,and mortality.RESULTS Baseline characteristics were largely comparable.AKI occurred in 45 patients(42.8%),which was significantly more in the SRD group(58.8%vs 27.7%;P=0.005).SRD was an independent predictor of AKI(odds ratio:4.85),and the risk of AKI was 66%lower in the SUD group(hazard ratio:0.34;P<0.001).While ascites control was numerically better in the SUD group,the difference was not statistically significant.The SUD group exhibited better hemodynamic and nutritional indices,including mean arterial pressure,mid-arm circumference,handgrip strength,and serum albumin.Mortality was significantly lower in the SUD group(29.6%vs 54.9%;P=0.009),and survival analysis consistently favored SUD.CONCLUSION Salt restriction in patients with cirrhosis with moderate to severe hyponatremia may predispose them to renal dysfunction,nutritional decline,and increased short-term mortality without providing a clear benefit in ascites control.These findings underscore the need for individualized sodium recommendations in patients with advanced cirrhosis. 展开更多
关键词 Dietary salt Sodium restriction Cirrhosis Hyponatremia Acute kidney injury Nutrition Sarcopenia
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Glutamine relieves feed restriction-induced ruminal epithelial function damage through histone lysine lactylation in yaks 认领 引用
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作者 Ziqi Yue Liyuan Shi +7 位作者 Zhisheng Wang Rui Hu Quanhui Peng Huawei Zou Jianxin Xiao Yahui Jiang Fali Wu Yiping Tang 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第2期1049-1063,共15页
Background As a unique livestock adapted to the harsh environment,grazing yaks frequently suffer from malnutrition and even death because of the lower yield and quality of forage in the Qinghai-Tibet Plateau during th... Background As a unique livestock adapted to the harsh environment,grazing yaks frequently suffer from malnutrition and even death because of the lower yield and quality of forage in the Qinghai-Tibet Plateau during the cold season.Certain stress conditions,such as environmental changes,disease,and malnutrition,can lead to a decrease in glutamine(Gln)synthesis,which fails to cover the physiological needs of the organism.Supplementation with exogenous Gln can promote nutrient digestion and improve rumen fermentation in ruminant animals under malnutrition.However,whether Gln could alleviate the barrier function injury induced by malnutrition and its mechanism is still unclear.Methods In the in vivo experiments,24 healthy yaks(31 months,265.35±25.81 kg)were randomly divided into 3 groups,namely control group(Con,free access to the basal diet),feed restriction group(FR,50%level of ad libitum feed intake),and feed restriction+Gln group(FR+Gln,50%level of ad libitum feed intake from d 1 to 30,50%level of ad libitum feed intake+1%Gln from d 31 to 60).In the in vitro experiments,the yak rumen epithelial cells(YRECs)were divided into 4 groups:Con group(complete medium),Gln group(complete medium+10 mmol/L Gln),Gln deficiency group(Gln-D,Gln-free medium),and Gln deficiency+Gln group(Gln-D+Gln,Gln-free medium+10 mmol/L Gln).Results In the in vivo experiments,FR significantly decreased the ruminal concentrations of acetate,propionate,butyrate,iso-butyrate,and total volatile fatty acid(VFA)(P<0.05).FR also reduced the m RNA expression of NHE1,Na+/K+-ATPase,and Ca2+/Mg2+-ATPase,and the concentrations of lactate,histone acetyltransferase(p300),histone deacetylase(HDAC),as well as the histone lysine lactylation level compared to Con group,while Gln supplementation alleviated them(P<0.05).In the in vitro experiments,Gln alleviated the Gln-D-induced down-regulation of NHE1,Na+/K+-ATPase,and Ca2+/Mg2+-ATPase m RNA expressions and reduction of lactate,p300,HDAC concentrations,and histone lysine lactylation level(P<0.05).Besides,p300 inhibitor abrogated Gln repair of barrier function damage in YRECs(P<0.05).Conclusions Overall,our results revealed the potential mechanism of Gln supplementation to repair malnutritioninduced damage of rumen epithelial barrier function in yaks,which might be related to histone lysine lactylation.However,because we do not have a control group receiving glutamine alone,we cannot determine the impact of Gln on the rumen epithelial function of normal yaks. 展开更多
关键词 Feed restriction Glutamine Glutamine deficiency Histone lysine lactylation Rumen epithelial cells Yak
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Asteroid impact trajectory based on Jupiter-perturbed Sun-Earth planar bicircular restricted four-body problem invariant manifolds 认领 引用
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作者 Meiling LI Yingjing QIAN +2 位作者 Wenxue CHEN Yan SHEN Yue LIU 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2026年第6期1279-1300,共22页
This paper proposes a novel low-energy impact trajectory design framework for near-Earth asteroids(NEAs), exploiting the dynamical properties of invariant manifolds within a Jupiter-perturbed Sun-Earth planar bicircul... This paper proposes a novel low-energy impact trajectory design framework for near-Earth asteroids(NEAs), exploiting the dynamical properties of invariant manifolds within a Jupiter-perturbed Sun-Earth planar bicircular restricted four-body problem(RFBP). First, we investigate the incuence of Jupiter's perturbation on the instantaneous Jacobi constant C, which governs the evolutionary behavior of the zero-velocity curves.An energy mechanism is then established to link the instantaneous C with the feasible region for asteroid entry into the Earth-Moon sphere of incuence(EMSOI). Using this mechanism, a screening procedure is developed to identify potential Earth-impacting asteroids by analyzing their accessible impact regions. Subsequently, low-energy impact trajectories are designed by joining unstable manifolds and the Lambert transfer, which is further optimized via the particle swarm optimization(PSO) algorithm. Finally, the numerical simulations conducted for asteroids 2010 XC15 and 2023 JD6 demonstrate that the proposed method significantly reduces propellant consumption. Overall, this study provides a practical and low-energy strategy for asteroid defense and deep-space mission design. 展开更多
关键词 asteroid defense feasible region invariant manifold zero-velocity curve restricted four-body problem(RFBP)
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Proteomic analyses in early brain development and neuropathological implications of fetal growth restriction 认领 引用
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作者 Gemma C.Ventura Kirat K.Chand +1 位作者 Paul B.Colditz Julie A.Wixey 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第10期4608-4616,共9页
Proteins are the primary functional units within cells,driving complex biological processes essential for stem cell differentiation into specific neural lineages and for the structural and functional maturation of the... Proteins are the primary functional units within cells,driving complex biological processes essential for stem cell differentiation into specific neural lineages and for the structural and functional maturation of the central nervous system.Advances in high-throughput proteomic technologies allow comprehensive profiling of molecular landscape of the brain,revealing dynamic,region-and time-specific changes in protein expression.During early embryonic development,pluripotency-associated proteins are highly expressed but gradually decline as lineagespecific markers and pathways governing DNA regulation and cytoskeletal organization become predominant.In fetal and postnatal stages,synaptic and metabolic proteins are enriched in a region-specific manner,reflecting functional compartmentalization and specialization in the central nervous system.Fetal growth restriction is an obstetric complication caused by sustained periods of inadequate oxygen and nutrient supply,preventing the fetus from achieving its genetic growth potential.Proteomic analysis of fetal tissues and biofluids has deepened our understanding of the molecular mechanisms associated with fetal growth restriction,highlighting metabolic and vascular adaptations,inflammatory responses and redox imbalances.These analyses have also uncovered molecular signatures with potential value as biomarkers for clinical diagnosis(e.g.,complement proteins in maternal blood in fetal growth restriction),and prognosis(e.g.,neurogenic locus notch homolog protein 1 as a modulator of fetal growth restriction response).Despite such advances,animal models remain indispensable for elucidating the multifactorial nature of fetal growth restriction-related neuropathology,pinpointing region-specific alterations.They also offer a controlled setting to explore how factors such as sex,gestational age at birth,and birth weight influence the impact of fetal growth restriction on brain development.A deeper understanding of neurodevelopmental processes and the pathological mechanisms involved in fetal growth restriction is critical for the development of effective diagnostic strategies and targeted therapeutic interventions.The purpose of this review is to provide synthesis of neuroproteomic alterations across developmental stages,highlighting how chronic intrauterine oxygen and nutrient deprivation,in humans and animals,shapes the proteomic landscape. 展开更多
关键词 biomarker brain development fetal growth restriction neuropathology proteomics
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Lifelong cognitive and motor outcomes after being born small for gestational age or with fetal growth restriction 认领 引用
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作者 Gemma Chavarria Ventura Harrigan Ryan +3 位作者 Hai-Nian Yu Kirat Kishore Chand Paul Bernard Colditz Julie Anne Wixey 《World Journal of Clinical Pediatrics》 2026年第2期125-140,共16页
Children born with fetal growth restriction(FGR)or small for gestational age(SGA)face an increased risk of motor and cognitive impairments,although prevalence and severity vary across studies due to differences in def... Children born with fetal growth restriction(FGR)or small for gestational age(SGA)face an increased risk of motor and cognitive impairments,although prevalence and severity vary across studies due to differences in definitions,assessment methods,and population characteristics.In recent years,advances in technology and clinical awareness have led to a growing body of research on the relationship between fetal growth and neurodevelopmental outcomes.This mini-review synthesises recent findings on the impact of SGA and FGR on neurodevelopment in preterm and term infants across the lifespan.Three databases were screened to identify original studies published between 2020 and 2025 with 40 studies meeting the selection criteria.Evidence suggests that children born SGA or with FGR are at higher risk of cognitive impairments,which may persist into later life;however,results from some preterm cohorts do not show significant associations.Findings on sensory and behavioural outcomes are limited and heterogeneous,reflecting the fewer studies that have addressed these domains.Regarding motor outcomes,reports on cerebral palsy remain inconsistent,with some studies suggesting no increased risk.In contrast,broader evaluations of motor function consistently indicate a higher prevalence,particularly among term-born cohorts.Together,these findings highlight the need for refined definitions,standardised assessment tools,and longitudinal studies to clarify the developmental trajectories of children born with growth complications and to guide early interventions. 展开更多
关键词 Small for gestational age Fetal growth restriction Preterm birth Cerebral palsy Neurodevelopmental impairments
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Infinite Families of Congruences Modulo 32 for Some Restricted Overpartition Functions 认领 引用
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作者 Wang Sijia Yao Olivia X M 《Journal of Mathematical Research with Applications》 CSCD 2026年第4期427-434,共8页
Recently,Baruah and Bandyopadhyay proved a number of congruences modulo 2,4,8 and 16 for p1,7(n),p1,4,7(n),p3,5(n)and p3,4,5(n),which count the number of overpartitions of a positive integer n into parts c... Recently,Baruah and Bandyopadhyay proved a number of congruences modulo 2,4,8 and 16 for p1,7(n),p1,4,7(n),p3,5(n)and p3,4,5(n),which count the number of overpartitions of a positive integer n into parts congruent to±1 modulo 8,congruent to±1 or 4 modulo 8,congruent to±3 modulo 8 and congruent to±3 or 4 modulo 8,respectively.At the end of their paper,they asked for congruences modulo 2k(k≥5)for those restricted overpartition functions.Motivated by their open problem,we prove several infinite families of congruences modulo 32 for p1,7(n),p1,4,7(n),p3,5(n)and p3,4,5(n). 展开更多
关键词 congruences overpartitions restricted overpartitions theta functions
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Blood flow restriction training in rehabilitation for knee conditions and elective knee procedures 认领 引用
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作者 Ahmed A Khalifa Wafaa S Soliman 《World Journal of Translational Medicine》 2026年第2期31-38,共8页
Rehabilitation protocols for various knee conditions and elective procedures are essential for restoring function and patient satisfaction,as these conditions are frequently associated with significant muscle strength... Rehabilitation protocols for various knee conditions and elective procedures are essential for restoring function and patient satisfaction,as these conditions are frequently associated with significant muscle strength loss and may eventually require prolonged recovery.This minireview highlights the adjunctive role of blood flow restriction(BFR)training in this context.The fundamental principles of BFR involve controlled external occlusion to induce physiological training effects with substantially reduced mechanical load.BFR was added to various rehabilitation protocols for patients with knee conditions,such as primary osteoarthritis and rheumatoid arthritis,and was also applied during the rehabilitation of patients undergoing knee-related surgical interventions,including anterior cruciate ligament reconstruction and total knee arthroplasty.Various studies,systematic reviews,and meta-analyses have shown the effectiveness of BFR in improving muscle strength and function,with added value for functional outcomes and patient satisfaction.Furthermore,it showed an acceptable safety profile.However,a clear description of the protocols for BFR,tailored to each patient and procedure,should be provided.Moreover,long-term data on BFR involvement in the rehabilitation protocols for different knee conditions and after various surgical procedures,compared with conventional rehabilitation protocols,are still required. 展开更多
关键词 Blood flow restriction Rehabilitation Knee joint Osteoarthritis Total knee arthroplasty Anterior cruciate ligament reconstruction
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Advances in surgical management of restrictive strabismus in thyroidassociated orbitopathy 认领 引用
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作者 Yiwen Zeng Hongru Chen +4 位作者 Jingjing Liu Zhuoma Gesang Te Zhang Huasheng Yang Huijing Ye 《Eye Science》 2026年第2期101-114,共14页
Recent advances in the surgical management of restrictive strabismus caused by thyroid-associated orbitopathy(TAO)demonstrate a clear trend toward precision and individualization.This review synthesizes current litera... Recent advances in the surgical management of restrictive strabismus caused by thyroid-associated orbitopathy(TAO)demonstrate a clear trend toward precision and individualization.This review synthesizes current literature,highlighting innovations in preoperative evaluation,surgical techniques,and outcome assessment over the past decade.Preoperative assessment has evolved from clinical observation alone to a comprehensive model incorporating serological markers and highresolution imaging,significantly improving the accuracy of surgical timing decisions.Surgical techniques have been refined to address a range of complex scenarios,enhancing predictability,success rates while reducing reoperation rates.Outcome measures now prioritize functional vision and patient-reported outcomes alongside ocular alignment.Furthermore,emerging therapies,including biologics,offer novel non-surgical options for active-phase disease management and perioperative care.Based on the evidence synthesized herein,the field is moving toward a more personalized approach;however,high-level prospective trials evaluating surgical strategies remain limited.Surgeons are encouraged to base decisions on comprehensive assessments to optimize functional and quality-of-life outcomes.Future directions may involve the integrating evolving biologic therapies with advanced data analytics,an approach that holds promise for further personalization. 展开更多
关键词 thyroid-associated orbitopathy restrictive strabismus strabismus surgery
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Letter to the Editor:Revisiting salt restriction in hyponatremic cirrhosis-a paradigm in need of refinement? 认领 引用
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作者 Cheng-Long Zou 《World Journal of Methodology》 2026年第3期330-333,共4页
The management of decompensated cirrhosis is fraught with clinical dilemmas,often requiring a delicate balance between opposing physiological principles.One such enduring controversy is the role of dietary sodium rest... The management of decompensated cirrhosis is fraught with clinical dilemmas,often requiring a delicate balance between opposing physiological principles.One such enduring controversy is the role of dietary sodium restriction,long considered a cornerstone in the management of ascites and fluid overload.The study by Marrapu et al published in the World Journal of Methodology,directly challenges this convention in a specific and vulnerable population:Patients with cirrhosis and moderate to severe hyponatremia.Their open-label randomized controlled trial provides compelling evidence that a salt-restricted diet(5 g/day)may be harmful compared to a more liberal,salt-unrestricted diet(10 g/day),associating salt-restricted diet with a significantly higher risk of acute kidney injury,poorer nutritional and hemodynamic profiles,and increased short-term mortality,without offering a clear benefit in ascites control. 展开更多
关键词 Cirrhosis Hyponatremia Sodium restriction Acute kidney injury Sarcopenia Nutritional status Mortality Dietary management
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Physiological adaptations and performance enhancement with combined blood flow restricted and interval training:A systematic review with meta-analysis 认领 引用 被引量：5
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作者 Mingyue Yin Shengji Deng +4 位作者 Jianfeng Deng Kai Xu George P.Nassis Olivier Girard Yongming Li 《Journal of Sport and Health Science》 SCIE CSCD 2025年第6期131-148,共18页
Purpose We aimed to determine:(a)the chronic effects of interval training(IT)combined with blood flow restriction(BFR)on physiological adaptations(aerobic/anaerobic capacity and muscle responses)and performance enhanc... Purpose We aimed to determine:(a)the chronic effects of interval training(IT)combined with blood flow restriction(BFR)on physiological adaptations(aerobic/anaerobic capacity and muscle responses)and performance enhancement(endurance and sprints),and(b)the influence of participant characteristics and intervention protocols on these effects.Methods Searches were conducted in PubMed,Web of Science(Core Collection),Cochrane Library(Embase,ClinicalTrials.gov,and International Clinical Trials Registry Platform),and Chinese National Knowledge Infrastructure on April 2,with updates on October 17,2024.Pooled effects for each outcome were summarized using Hedge's g(g)through meta-analysis-based random effects models,and subgroup and regression analyses were used to explore moderators.Results A total of 24 studies with 621 participants were included.IT combined with BFR(IT+BFR)significantly improved maximal oxygen uptake(VO2max)(g=0.63,I2=63%),mean power during the Wingate 30-s test(g=0.70,I2=47%),muscle strength(g=0.88,I2=64%),muscle endurance(g=0.43,I2=0%),time to fatigue(g=1.26,I2=86%),and maximal aerobic speed(g=0.74,I2=0%)compared to IT alone.Subgroup analysis indicated that participant characteristics including training status,IT intensity,and IT modes significantly moderated VO2max(subgroup differences:p<0.05).Specifically,IT+BFR showed significantly superior improvements in VO2maxcompared to IT alone in trained individuals(g=0.76)at supra-maximal intensity(g=1.29)and moderate intensity(g=1.08)as well as in walking(g=1.64)and running(g=0.63)modes.Meta-regression analysis showed cuff width(β=0.14)was significantly associated with VO2maxchange,identifying 8.23 cm as the minimum threshold required for significant improvement.Subgroup analyses regarding muscle strength did not reveal any significant moderators.Conclusion IT+BFR enhances physiological adaptations and optimizes aspects of endurance performance,with moderators including training status,IT protocol(intensity,mode,and type),and cuff width.This intervention addresses various IT-related challenges and provides tailored protocols and benefits for diverse populations. 展开更多
关键词 Blood flow restricted training Interval training Meta-analysis
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Early life food intake modulates effects of diet restriction on lifespan and fecundity in later life in a predatory mite(Acari:Phytoseiidae) 认领 引用
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作者 Yun Xu Keshi Zhang +1 位作者 Xiao Han Zhi-Qiang Zhang 《Current Zoology》 SCIE CAS CSCD 2025年第3期295-303,共9页
The nutritional status of an individual can significantly influence its life history traits,including development,growth,reproduction,and survival.In the predatory mite Phytoseiulus persimilis Athias-Henriot(Acari:Phy... The nutritional status of an individual can significantly influence its life history traits,including development,growth,reproduction,and survival.In the predatory mite Phytoseiulus persimilis Athias-Henriot(Acari:Phytoseidae),the plasticity of life history traits,such as developmental time and size at maturity,is influenced by the quality and quantity of food.This study aimed to investigate the effects of dietary restriction at different life stages(i.e.,juvenile,early adulthood,and later adulthood)on the lifespan and fecundity of P persimilis.We found that reduced dietary intake during early adulthood resulted in a shorter lifespan for both male and female P persimilis.Furthermore,this study demonstrated a sex-specific response to dietary restriction:it extended the lifespan of males but reduced that of females during later adulthood.Diet restriction during the postovipositional period of females showed the most variable life history trait response.Our results showed that the impact of diet restriction at different life stages can have combined influences on the postovipositional duration of P persimilis,where the individuals receiving diet restriction during immature development and early adulthood had a greater reduction in ovipositional duration as those experiencing diet restriction during late adulthood.In addition,we observed a positive correlation between the lifespan and fecundity of females,with higher prey availability increasing both.The insights obtained from our research contribute to a better understanding of the aging process and dietary requirements of P persimilis,which can facilitate the development of more effective biological control strategies using this predator for spider mites in agriculture. 展开更多
关键词 aging diet restriction fecundity phenotypic plasticity Phytoseiulus persimilis silver-spoon hypothesis.
Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training 认领 引用
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作者 Xiaolei Chu Jiaojiao Sun +4 位作者 Jiajia Liang Wenjie Liu Zheng Xing Qi Li Qingwen Li 《Sports Medicine and Health Science》 CSCD 2025年第3期173-184,共12页
This review elucidates the impact of electrical stimulation(ES)and blood flow restriction(BFR)training on muscle function.ES induces a transformation in muscle fibers type by rearranging myosin heavy chain isoform pat... This review elucidates the impact of electrical stimulation(ES)and blood flow restriction(BFR)training on muscle function.ES induces a transformation in muscle fibers type by rearranging myosin heavy chain isoform patterns.Additionally,it influences muscle protein synthesis and degradation through specific signaling pathways such as protein kinase B/mechanistic target of rapamycin(Akt/mTOR),as well as via autophagy and the ubiquitin-proteasome system,thereby effectively maintaining muscle mass.BFR,on the other hand,restricts muscle blood flow,leading to metabolic products accumulation and localized hypoxia,which not only promotes the recruitment of fast-twitch fibers but also activates the mTOR signaling pathway,enhancing muscle protein synthesis.The combination of ES and BFR synergistically facilitates muscle protein synthesis through the mTOR pathway,thereby accelerating the recovery of muscle function following peripheral nerve injury. 展开更多
关键词 Electrical stimulation Blood flow restriction Muscle fibers mTOR Muscle protein synthesis
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The effect of blood flow restricted exercise on measures of health and physical fitness across all populations:An umbrella review and meta-meta-analysis 认领 引用
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作者 Cooper Oborn Maximillian JNelson +4 位作者 Kade Davison James Murray Kent Green Jawaria Shahid Hunter Bennett 《Sports Medicine and Health Science》 CSCD 2025年第6期419-431,共13页
Purpose:To consolidate and evaluate meta-analyses reporting the effects of blood flow restricted exercise(BFRE)on measures of health and physical fitness across all populations.Methods:This preregistered umbrella revi... Purpose:To consolidate and evaluate meta-analyses reporting the effects of blood flow restricted exercise(BFRE)on measures of health and physical fitness across all populations.Methods:This preregistered umbrella review followed PRISMA guidelines.A comprehensive search of five databases identified meta-analyses evaluating the effects of BFRE interventions(aerobic,resistance,combined)compared to exercising and non-exercising control conditions on measures of health and performance.A multilevel meta-analysis of standardised mean differences(SMDs)was conducted to examine the effects of BFRE.Subgroup analyses were conducted for the participant and intervention characteristics.Risk of bias was assessed using the AMSTAR-2.Results:47 meta-analyses comprised of 265 unique studies were included.All reviews were rated as low-moderate quality.BFRE had a small effect on hypertrophy(SMD=0.39,p<0.001)and a moderate effect on strength(SMD=0.61,p<0.001)when compared to low load,but not high load resistance training(hypertrophy,SMD=-0.13,p=0.142;strength,SMD=-0.28,p<0.001).BFRE had small-to-moderate effects on aerobic fitness(SMD=0.50,p<0.001),vascular health(SMD=0.45,p<0.001),blood pressure(SMD=0.46,p<0.001),and muscular power(SMD=0.56,p<0.001).BFRE had no effect on physical function(SMD=0.16,p=0.096),pain(SMD=0.00,p=0.996),and speed(SMD=0.22,p=0.213).Conclusions:BFRE is a viable option to improve hypertrophy,strength,aerobic fitness,and vascular health across various populations,though its effects on hypertrophy and strength are smaller when compared to traditional high load resistance training.It doesn't appear to offer any additional benefits than other training methods for physical function,pain,or speed,although sub-analyses suggest further research is warranted in select areas of application. 展开更多
关键词 Bloodflow occlusion Bloodflow restriction KAATSU Rehabilitation Hypertrophy Strength Performance
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Effect of blood flow restriction on muscle strength and stability following foot and ankle injury: A systematic review 认领 引用
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作者 Julia M Balboni Karthik Madhira +3 位作者 Victor Martinez Wei-Shao Tung John G Kennedy Arianna L Gianakos 《World Journal of Orthopedics》 2025年第6期118-130,共13页
BACKGROUND Poor musculoskeletal recovery following foot and ankle injury can result in chronic instability and persistent muscle weakness.Preliminary evidence has shown that blood flow restriction(BFR)rehabilitation c... BACKGROUND Poor musculoskeletal recovery following foot and ankle injury can result in chronic instability and persistent muscle weakness.Preliminary evidence has shown that blood flow restriction(BFR)rehabilitation can increase muscle strength and stability,helping to restore physical function and prevent repeated injury.AIM To determine whether BFR is more effective than traditional rehabilitation in improving muscle strength,size,and stability after foot and ankle injury.METHODS A systematic review and meta-analysis were performed.Articles were retrieved from MEDLINE,EMBASE,and CENTRAL databases.Included studies compared the effectiveness of BFR rehabilitation to traditional foot and ankle rehabilitation exercises.Eligible patients were those with a history of foot or ankle injury.Muscle strength,size,and dynamic balance were assessed by comparing impro vements in peak torque,cross-sectional area,and percent muscle activation.Methodological quality assessments were performed using the PEDro scale and Methodological Index for Non-Randomized Studies(MINORS).RESULTS Ten studies met the inclusion criteria.Five studies were of good to excellent quality according to the PEDro scale,and 5 studies were of moderate quality as per the MINORS criteria.Two studies compared the effect of BFR and non-BFR rehabilitation on muscle strength;the overall mean difference between the BRF and non-BFR groups was 0.09[95%CI:(0.05,0.12),P<0.0001].Two studies analyzed muscle activation following BFR and non-BFR rehabilitation;the overall mean difference between the BRF and non-BFR groups was 0.09[95%CI:(0.05,0.12),P<0.0001].Data on dynamic balance was synthesized from two studies;the mean difference between the BFR and control groups was 1.23[95%CI:(-1.55,4.01);P=0.39].CONCLUSION BFR rehabilitation is more effective than non-BFR rehabilitation at improving muscle strength and activation following foot and ankle injury.Additional studies are needed to develop a standardized BFR training protocol. 展开更多
关键词 Ankle fracture Blood flow restriction Chronic ankle instability Muscle activation Muscle hypertrophy Musculoskeletal rehabilitation
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Static Characteristic Analysis of Aerostatic Porous Bearing with a Restricted Layer 认领 引用
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作者 YU Zhe YAN Ruzhong +1 位作者 MA Xiaojian ZHANG Haojie 《Journal of Donghua University(English Edition)》 CAS 2025年第5期543-549,共7页
To enhance the gas-damping effect and improve the bearing performance,a restricted layer is applied on the surface of aerostatic porous bearings.Based on the gas lubrication theory,a mathematical model of an aerostati... To enhance the gas-damping effect and improve the bearing performance,a restricted layer is applied on the surface of aerostatic porous bearings.Based on the gas lubrication theory,a mathematical model of an aerostatic porous bearing with a restricted layer is established,and two proportional coefficients,a permeability ratio δ and a thickness ratioγ,are proposed.Critical values of δ and γ are determined through sensitivity analyses of complex restriction-layer parameters.The static characteristics of aerostatic porous bearings with a restricted layer or an unrestricted layer are comparatively analyzed by using Fluent simulation.The results show that when δ≈0.005 and γ≈0.010,the load capacity and static stiffness of the restricted-layer aerostatic porous bearing are high;compared with the unrestricted-layer aerostatic porous bearing,the restricted-layer aerostatic porous bearing has a lower sensitivity to changes in the air supply area.The existence of the restricted layer not only enhances the throttling effect and reduces the mass flow rate,but also effectively improves the static stiffness of the bearing. 展开更多
关键词 aerostatic porous bearing restricted layer static characteristic critical coefficient
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Do rootstock-scion combinations and irrigation water salinity affect the growth and yield of grafted tomatoes under root-restricted conditions? 认领 引用
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作者 Astrit Balliu Gerta Pellumbi Glenda Sallaku 《Technology in Horticulture》 2025年第1期153-161,共9页
The experiment evaluated the impact of several commercial rootstocks on the growth and yield of a selected tomato cultivar under restricted volume conditions.The experiment included six different rootstocks and a sing... The experiment evaluated the impact of several commercial rootstocks on the growth and yield of a selected tomato cultivar under restricted volume conditions.The experiment included six different rootstocks and a single tomato cultivar(Solanum lycopersicum cv.Izmir).The respective rootstock-scion combination and self-grafted tomato plants were tested in a randomized complete block design.The plants,transplanted into 5 L plastic pots,were irrigated daily with equal amounts of a nutrient solution and were subject to two different levels of salinity,0-or 50-mM NaCl solution,respectively.The relative stem elongation rate and new leaf emergence rate were calculated from day 1 to day 42 after transplanting,and nutrient concentrations of mature leaves were analyzed by the end of this period.Fruits were harvested at full maturity,and Brix(°Bx)and fruit acidity were measured using a digital refractometer.While the Na concentration of mature leaves significantly increased,the rise of salinity in the nutrient solution significantly reduced the plants'relative growth rate,K and P concentration of mature leaves,and the yield of tomato plants.Although the grafted plants demonstrated improved shoot growth and increased new leaf emergence rate,indicating enhanced capabilities to alleviate salinity stress,most of the rootstocks did not contribute to any increase in tomato yield.Since only carefully selected rootstock-scion combinations might contribute to higher yields and better quality,the introduction of new rootstocks should be followed by continuous testing of their compatibility with specific,well-recognized tomato cultivars under diverse growing conditions. 展开更多
关键词 nutrient solution rootstock scion combinations growth root restricted conditions grafted tomatoes yield relative stem elongation rate randomized complete block designthe
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