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Derivation and application of time step model in solidification process simulation 认领 引用
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作者 GONG Wen-bang CHEN Li-liang +1 位作者 LIU Rui-xiang HAO Jing 《China Foundry》 SCIE CAS 2007年第3期206-209,共4页
The heat transfer during the casting solidification process includes the heat radiation of the high temperature casting and the mold,the heat convection between the casting and the mold,and the heat conduction inside ... The heat transfer during the casting solidification process includes the heat radiation of the high temperature casting and the mold,the heat convection between the casting and the mold,and the heat conduction inside the casting and from the casting to the mold. In this paper,a formula of time step in simulation of solidification is derived,considering the heat radiation,convection and conduction based on the conservation of energy. The different heat transfer conditions between the conventional sand casting and the permanent mold casting are taken into account in this formula. The characteristics of heat transfer in the interior and surface of the casting are also considered. The numerical experiments show that this formula can avoid computational dispersion,and improve the computational efficiency by about 20% in the simulation of solidification process. 展开更多
关键词 castina solidification simulation time step formula derivation
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Experimental and in silico studies on three hydrophobic charge-induction adsorbents for porcine immunoglobulin purification 认领 引用 被引量：2
2
作者 Qilei Zhang Tiantian Zhuang +3 位作者 Hongfei Tong Hongyin Wang Dongqiang Lin Shanjing Yao 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2016年第1期151-157,共7页
Three hydrophobic charge-induction adsorbents with functional ligands of 4-mercapto-ethyl-pyridine, 2-mercapto-methyl-imidazole or 2-mercapto-benzimidazole were evaluated in the purification of porcine immunoglobulin ... Three hydrophobic charge-induction adsorbents with functional ligands of 4-mercapto-ethyl-pyridine, 2-mercapto-methyl-imidazole or 2-mercapto-benzimidazole were evaluated in the purification of porcine immunoglobulin from porcine blood. Adsorption isotherms were studied under different pH conditions. The adsorbent with 2-mercapto-methyl-imidazole as the ligand showed reasonable adsorption capacity(43.60 mg·g-1gel)with great selectivity and it also showed the best elution performance in chromatographic studies. A multi-pH step elution process was proposed for the 2-mercapto-methyl-imidazole adsorbent, and the results showed that high immunoglobulin purity(94.3%) and a yield of 9.8 mg·(ml plasma)-1 could be achieved under the optimal condition of loading(pH 5.0)–pre-elution(pH 7.0)–elution(pH 3.8). Moreover, molecular simulation was employed to help in analyzing the binding mechanism between the ligands and immunoglobulin, and the results showed that both 2-mercapto-benzimidazole and 2-mercapto-methyl-imidazole ligands were docked on the same pocket(around TYR319 and LEU309) of the Fc fragment of immunoglobulin, with 2-mercaptobenzimidazole showing stronger binding interactions. 展开更多
关键词 Hydrophobic charge-induction chromatography Porcine immunoglobulin Step elution Molecular simulation
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