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Schisandrae Fructus oil-induced elevation in serum triglyceride and lipoprotein concentrations associated with physiologic hepatomegaly in mice 认领 引用
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作者 Si-Yuan Pan Xue-Lan Song +11 位作者 Zhao-Heng Lin Qing Yu Yi Zhang Hai-Chuan Tai Gan Luo Xiao-Yan Wang Pei-Li Zhu Nan Sun Zhu-Sheng Chu Zhi-Ling Yu Yi Zhang Kam-Ming Ko 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2022年第2期59-68,共10页
Objective:To investigate hypertriglyceridemia and hepatomegaly caused by Schisandrae Sphenantherae Fructus(FSS)and Schisandra chinensis Fructus(FSC)oils in mice.Methods:Mice were orally administered a single dose of S... Objective:To investigate hypertriglyceridemia and hepatomegaly caused by Schisandrae Sphenantherae Fructus(FSS)and Schisandra chinensis Fructus(FSC)oils in mice.Methods:Mice were orally administered a single dose of SchisandraeFructusoils.Serumandhepatictriglyceride(TG),triglyceridetransferprotein(TTP),apolipoproteinB48(Apo B48),very-low-densitylipoprotein(VLDL),hepatocytegrowth factor(HGF),alanine aminotransfease(ALT)and liver index were measured at 6-120 h post-dosing.Results:FSS and FSC oil caused time and dose-dependent increases in serum and hepatic TG levels,with maximum increases in the liver(by 297%and 340%)at 12 h post-dosing and serum(244%and 439%)at 24-h post-dosing,respectively.Schisandrae Fructus oil treatments also elevated the levels of serum TTP by 51%and63%,Apo B48 by 152%and 425%,and VLDL by 67%and 38%in mice,respectively.FSS and FSC oil treatments also increased liver mass by 53%and 55%and HGF by 106%and 174%,but lowered serum ALT activity by 38%and 22%,respectively.Fenofibrate pre/co-treatment attenuated the FSS and FSC oil-induced elevation in serum TG levels by 41%and 49%at 48 h post-dosing,respectively,but increased hepatic TG contents(by 38%and 33%,respectively)at 12 h post-dosing.Conclusions:Our findings provide evidence to support the establishment of a novel mouse model of hypertriglyceridemia by oral administration of FSS oil(mainly increasing endogenous TG)and FSC oil(mainly elevating exogenous TG). 展开更多
关键词 Schisandrae Fructus oils Triglyceride Alanine aminotransferase Hepatomegaly Mouse model Hypertriglyceridemia
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How Schisandrae Fructus Benefits the Body: Mechanisms in Traditional Chinese Medicine and Modern Medicine 认领 引用
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作者 Kam Ming Ko Hoi Yan Leung 《Chinese Medicine》 CAS 2024年第3期75-81,共7页
Schisandrae chinensis Fructus (SF) is a commonly used herb in Traditional Chinese Medicine (TCM). According to TCM theory, SF can invigorate Qi in the liver and other visceral organs through the meridian system. Furth... Schisandrae chinensis Fructus (SF) is a commonly used herb in Traditional Chinese Medicine (TCM). According to TCM theory, SF can invigorate Qi in the liver and other visceral organs through the meridian system. Furthermore, the liver’s pivotal role in regulating the functions of various visceral organs helps explain how SF can promote holistic health benefits. The main active ingredient of SF, schisandrin B (Sch B), has been found to improve mitochondrial ATP production and enhance glutathione redox status in multiple organs. This could account for the overall protective effects of Sch B on organs. Due to its stronger impact on liver function, the positive influence of Sch B on different organs may be facilitated by signal molecules originating from the liver. 展开更多
关键词 Schisandrae chinensis Fructus Schisandrin B Mitochondrial Glutathione Redox Status Liver
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Inhibition mechanism of compound ethanol extracts from Wuweizi(Fructus Schisandrae Chinensis) on renal interstitial fibrosis in diabetic nephropathy model mice 认领 引用 被引量：6
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作者 Yanqiu Zhang Daning Zhang Mianzhi Zhang 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2012年第4期669-673,共5页
OBJECTIVE：To evaluate inhibition effect and mech- anism of compound ethanol extracts from Wuweizi （Fructus Schisandrae Chinensis）, Chuanxiong （Rhi- zoma Chuanxiong） and Muli （Cocha Ostreae） （FRC） on glomerula... OBJECTIVE：To evaluate inhibition effect and mech- anism of compound ethanol extracts from Wuweizi （Fructus Schisandrae Chinensis）, Chuanxiong （Rhi- zoma Chuanxiong） and Muli （Cocha Ostreae） （FRC） on glomerular and tubular interstitial fibrosis in streptozocin （STZ）-induced diabetic nephropathy （ND） model mice. METHODS： Twenty-seven male C57BL/6 mice were divided randomly into 3 groups： nondibetic （ND）, STZ-induced diabetic （D）, and STZ-induced diabetic that were treated with .5 g. kg1. daylof FRC by oral gavage （DFRc）, with 9 in each group. The protein ex- pressions of E-cadherin, a-smooth muscle actin （a-SMA）, Plasminogen Activator Inhibitor-1 （PAl-l） in renal tissues were investigated by Western blot- ting. The expressions of fibronectin （FN） and o-SMA were detected by immunohistochemical method. The morphological changes of renal tissues were observed under a microscope. RESULTS： Renal tissues in the DFRC group showed a lessened degree of fibrosis. Meanwhile, the expres- sions of FN, o-SMA and PAl-lwere significantly lower in the DrRc group than those in the D group （all P〈0.05）.CONCLUSION： FRC can ameliorate the DN in the C57BL/6 mice, and its mechanism may relate to in- hibition on the epithelial to mesenchymal transdif- ferentiation, endothelial-myofibroblast transition and PAl-1 expression. 展开更多
关键词 Schisandrae chinensis Compounds Ex-traction Diabetic nephropathies Fibrosis
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Preparative separation and purification of deoxyschizandrin from Schisandrae Sphenantherae Fructus by high-speed counter-current chromatography 认领 引用 被引量：2
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作者 Xin-Ying Li Mei Yang +5 位作者 Jie-Yun Huang Xiao-Xue Yua Min-Qian Zhao Zhi-Kun Liang Zhi-Sheng Xie Xin-Jun Xu 《Journal of Pharmaceutical Analysis》 CAS 2013年第6期429-433,共5页
A high-speed counter-current chromatography （HSCCC） method was successfully developed for the preparative separation and purification of deoxyschizandrin from Schisandrae Sphenantherae Fructus in one step. The purit... A high-speed counter-current chromatography （HSCCC） method was successfully developed for the preparative separation and purification of deoxyschizandrin from Schisandrae Sphenantherae Fructus in one step. The purity of deoxyschizandrin was 98.5%, and the structure was identified by MS, UV and NMR. This method was simple, fast, convenient and appropriate to prepare pure compound as reference substances for related research on Schisandrae Sphenantherae Fmctus. 展开更多
关键词 Schisandrae Sphe-nantherae Fructus High-speed counter-cur-rent chromatography（HSCCC） Deoxyschizandrin
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Lignans are the main active components of Schisandrae Chinensis Fructus for liver disease treatment:a review 认领 引用
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作者 Ke Fu Shu Dai +6 位作者 Cheng Ma Yafang Zhang Shenglin Zhang Cheng Wang Lihong Gong Honglin Zhou Yunxia Li 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第5期2425-2444,共20页
As a traditional Chinese herbal medicine,Schisandrae Chinensis Fructus(SC)has been used in medicine and food industry due to its health care and therapeutic effects.Over the past 20 years,the use of SC and its active ... As a traditional Chinese herbal medicine,Schisandrae Chinensis Fructus(SC)has been used in medicine and food industry due to its health care and therapeutic effects.Over the past 20 years,the use of SC and its active ingredient lignans in the prevention and treatment of liver diseases has been increasing,and their hepatoprotective effects has increased the interest of the public and academia.Therefore,in the present work,we first determined the effectiveness of SC in the treatment of liver diseases such as metabolic associated fatty liver disease,alcoholic liver disease,cholestatic liver disease and acute liver injury.Subsequently,the pharmacological effects and molecular mechanisms of lignans,the active components of SC,for liver disease treatment were comprehensively summarized for the first time.The results showed that the lignans in SC could achieve hepatoprotective effects by regulating lipid metabolism,anti-fibrosis,anti-inflammation,anti-oxidation,anti-tumor and regulating bile acid metabolism.The mechanism mainly involved adenosine 5’-monophosphate-activated protein kinase,endoplasmic reticulum stress,sterol regulatory element binding protein 1c,autophagy,transforming growth factor-β,mitogen-activated protein kinase,microRNA,nuclear factor kappa-B,nuclear factor erythroid-2-related factor 2,heat shock proteins and pregnane X receptor signaling pathways.These results can lay a scientific foundation for the development of hepatoprotective drugs or functional foods from SC/lignans. 展开更多
关键词 Schisandrae Chinensis Fructus Lignans Hepatoprotection Pharmacological effects Molecular mechanism
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Effect of methanol extract of Schisandrae Fructus on high fat diet induced hyperlipidemic mice 认领 引用 被引量：1
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作者 Se-Eun Lee Hyungwoo Kim +2 位作者 Chang-Hyun Kim Chiyeon Lim Suin Cho 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2019年第6期818-825,共8页
OBJECTIVE:To investigate the effects and molecular targets of Schisandrae Fructus(SF)methanol extract(SFme)in mice with hyperlipidemia induced by high fat diet.METHODS:We observed changes in body weight,blood serum co... OBJECTIVE:To investigate the effects and molecular targets of Schisandrae Fructus(SF)methanol extract(SFme)in mice with hyperlipidemia induced by high fat diet.METHODS:We observed changes in body weight,blood serum content of total cholesterol,high-density lipoprotein(HDL)-cholesterol,and triglyceride.The extent of accumulation of lipid peroxide due to lipid metabolism disorder also evaluated by measuring malondialdehyde(MDA)level.In addition,after getting gene expression in hepatic tissues,target protein of SFme was identified using a protein interaction database.RESULTS:SFme significantly decreased total cholesterol and triglyceride levels without alteration of body weight in mice,and the livercontent of MDA was statistically decreased by SFme.And expression changes of cyclindependent kinase 1(Cdk1)and leucine-rich repeat kinase 2(Lrrk2)were restored by SFme.CONCLUSION:The effect of SFme on the highfat-diet induced hyperlipidemia via decreasing total cholesterol and triglyceride levels may involve the expression of Cdk1 and Lrrk2 proteins. 展开更多
关键词 Schisandra hyperlipidemias Obesity Cardiovascular diseases CDC2 protein kinase
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Effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on chemotactic migration of alveolar macrophages and inters regions macrophages in rats 认领 引用 被引量：3
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作者 Yuan Yiping Zhai Huaqiang +7 位作者 Zhang Tian Guo Zhaojuan Kong Liting Jia Xiaoyu Wang Ningning Dai Ying Liu Guoxiu Wang Yanping 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2017年第5期607-615,共9页
OBJECTIVE: To observe the effects of serum containing Mahuang(Herba Ephedra Sinica) or Wuweizi(Fructus Schisandrae Chinensis) on the migration of alveolar macrophages(AM) and interstitial macrophages(IM) from normal r... OBJECTIVE: To observe the effects of serum containing Mahuang(Herba Ephedra Sinica) or Wuweizi(Fructus Schisandrae Chinensis) on the migration of alveolar macrophages(AM) and interstitial macrophages(IM) from normal rats, and to analyze and compare the mechanisms leading to cell migration differences.METHODS: Rats were randomly divided into three groups: Mahuang(Herba Ephedra Sinica), Wuweizi(Fructus Schisandrae Chinensis), and blank serum. After treatment with the herbs, serum was extracted from the rats. AM and IM were isolated from normal rats and cultured. The effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on normal rat AM and IM chemotactic migration were determined by transwell assays. The CC chemokine receptor(CCR) 2, CCR5, voltage-gated Kvl. 3 K^+channel(Kv1. 3), and voltage-gated Kvl. 5 K^+channel(Kv1. 5) protein levels were analyzed by western blotting.RESULTS: The migration quantities of AM and IM in the Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum groups were significantly higher than those in the blank serum group(P < 0.01). Compared with the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group, the migration quantity of cultured rat AM in the Mahuang(Herba Ephedra Sinica) medicated serum group was significantly increased(P <0.01). Meanwhile, compared with the Mahuang(Herba Ephedra Sinica) medicated serum group, the migration quantity of cultured rat IM in the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group was significantly increased(P < 0.01).CCR2, CCR5, Kv1. 3, and Kv1. 5 proteins were expressed on the AM cell surface, and showed significantly higher expression in the Mahuang(Herba Ephedra Sinica) medicated serum group compared with the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group. In contrast, CCR5, Kv1.3,and Kv1.5 proteins were expressed on the IM cell surface, and showed significantly higher expression in the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group compared with the Mahuang(Herba Ephedra Sinica) medicated serum group.CONCLUSION: Mahuang(Herba Ephedra Sinica)and Wuweizi(Fructus Schisandrae Chinensis) can promote AM and IM migration ability, with Mahuang(Herba Ephedra Sinica) targeting AM more apparently and Wuweizi(Fructus Schisandrae Chinensis) targeting IM more apparently. The mechanism may be that, by stimulating cells, Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) promote expression of CCR2 and CCR5 receptors on the AM and IM cell surface,which pass signals to Kvl.3 and Kvl.5 ion channels,leading to changes in the cytoskeleton, and ultimately promoting chemotactic cell migration. 展开更多
关键词 Ephedra sinica Schisandra Chinensis Macrophage Receptors CCR Delayed rectifier po tassium channel Chemotaxis
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Immunomodulatory effect of schisandrae oil in mouse model of autoimmune hepatitis induced by concanavalin A 认领 引用 被引量：1
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作者 Wen-Qian Dong Peng Luo +2 位作者 Da-Peng Lu Hao Wang Bao-Long Wang 《Traditional Medicine Research》 2019年第5期227-236,共10页
Objective:To study the immunomodulatory effect of schisandra oil (SCO) in mouse model of autoimmune hepatitis induced by concanavalin A (ConA). Methods: C57BL/6 mice were divided into control group, model group and SC... Objective:To study the immunomodulatory effect of schisandra oil (SCO) in mouse model of autoimmune hepatitis induced by concanavalin A (ConA). Methods: C57BL/6 mice were divided into control group, model group and SCO group. Mice in SCO group were given SCO at 5 mg/kg by intragastric administration every day for 7 days, followed by intravenous injection of ConA at 10 mg/kg. 10 hours after ConA injection, the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were measured by the kits, the expression of inflammatory cytokines like interferon-γ(IFN-γ), interleukin-4 (IL-4), interleukin-17 (IL-17), tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β) and interleukin-6 (IL-6) in liver was detected by real-time quantitative PCR, and the T cell activation and IFN-γ expression in spleen and MLN were examined by flow cytometry. Results: Compared with control group, each indicator in model group were significantly higher. In SCO preventive treatment group, the levels of serum ALT, AST and LDH were significantly reduced (all P < 0.001), the expression levels of inflammatory cytokines in liver were downregulated, the T cell activation in spleen and MLN was inhibited (P = 0.006 and P = 0.008), the percentages of IFN-γ+ CD8+ and IFN-γ+ CD4+ T cells were decreased, and the frequencies of Th2 and Th17 cells in spleen and MLN were also decreased at the same time. Conclusion: SCO has a protective effect on immune liver injury by inhibiting the activation of T cells and reducing the expression of inflammatory cytokines, which reflects that SCO plays a role in the immunomodulation of autoimmune hepatitis, indicating that SCO is of great significance for the maintenance of autoimmune homeostasis. 展开更多
关键词 Schisandra oil Autoimmune hepatitis Immunomodulation Concanavalin A Inflammatory cytokines T cells
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Effects of Schisandrae Fructus alone or in combination in viral hepatitis treatment:A systematic review and meta-analysis of randomized controlled trials 认领 引用 被引量：1
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作者 Lujie Lin Mingxiao Zhang +5 位作者 Huijuan Xie Min Yang Tong Zhu Junxuan Yang Bin Yang Hua Li 《Science of Traditional Chinese Medicine》 CSCD 2025年第1期69-80,共12页
Background:Viral hepatitis causes annual deaths of 1.4 million people.Antiviral therapy rarely cures the disease,and patients are usually required to maintain lifelongmedication,leading to cumulative drug toxicity.Sch... Background:Viral hepatitis causes annual deaths of 1.4 million people.Antiviral therapy rarely cures the disease,and patients are usually required to maintain lifelongmedication,leading to cumulative drug toxicity.Schisandrae Fructus(SF)is efficacious in the treatment of viral hepatitis.Objective:The systematic review and meta-analysis aim to examine the efficacy and safety of SF alone or in combination with specific and nonspecific treatments for treating viral hepatitis by analyzing the clinical trials performed up to date.Methods:An extensive literature was searched in 7 databases from inception to May 2023.Final outcomes were divided into the primary outcomes containing the total effective rate and virological responses,as well as the secondary outcomes containing liver biochemical functions and frequencies of adverse events.RevMan 5.3 and GRADE pro 3.6 software were used for meta-analysis and assessment of evidence quality.Subgroup analysis was conducted to explore the source of the heterogeneity.Results:Twenty-nine randomized controlled trials were included in the meta-analysis.SF treatment was comparable with western medicines or other traditional Chinese treatments in terms of primary and secondary outcomes.In combination with specific treatments with antiviral medicines,SF group reduced 18.45 U/L of alanine aminotransferase levels[weighted mean difference:18.45,95%confidence interval(CI):(16.12,20.78),p<0.00001]and 8.37U/L of aspartate aminotransferase levels[weighted mean difference:8.37,95%CI:(1.25,15.48),p=0.02],andit decreased the levels of hyaluronic acid(HA)[standardmean difference(SMD):0.92,95%CI:(0.58,1.27),p<0.00001],laminin(LN)[SMD:0.64,95%CI:(0.38,0.90),p<0.00001],and procollagen type Ⅲ[SMD:0.48,95%CI:(0.28,0.67),p<0.00001],while increasing the total effective rate by 24%[risk ratio:1.24,95%CI:(1.15,1.32),p<0.00001].There were no severe adverse events during treatment.Conclusions:SF was a potential adjuvant for antiviral therapy in restoring liver function.However,the poor quality of the included randomized controlled trials limited the recommendations.More long-term,randomized,and double-blind studies should be performed to assess the efficacy and safety of combination therapy. 展开更多
关键词 Schisandrae Fructus Traditional Chinesemedicine Combination therapy Viral hepatitis Systematic review Meta-analysis
Extract of Fructus Schisandrae chinensis Inhibits Neuroinflammation Mediator Production from Microglia via NF-κB and MAPK Pathways 认领 引用 被引量：4
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作者 SONG Fang-jiao ZENG Ke-wu +4 位作者 CHEN Jin-feng LI Yuan SONG Xiao-min TU Peng-fei WANG Xue-mei 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2019年第2期131-138,共8页
Objective: To investigate the anti-neuroinflammation effect of extract of Fructus Schisandrae chinensis(EFSC) on lipopolysaccharide(LPS)-induced BV-2 cells and the possible involved mechanisms. Methods: Primary cortic... Objective: To investigate the anti-neuroinflammation effect of extract of Fructus Schisandrae chinensis(EFSC) on lipopolysaccharide(LPS)-induced BV-2 cells and the possible involved mechanisms. Methods: Primary cortical neurons were isolated from embryonic(E17-18) cortices of Institute of Cancer Research(ICR) mouse fetuses. Primary microglia and astroglia were isolated from the frontal cortices of newborn ICR mouse. Different cells were cultured in specific culture medium. Cells were divided into 5 groups: control group, LPS group(treated with 1 μg/mL LPS only) and EFSC groups(treated with 1 μg/mL LPS and 100, 200 or 400 mg/mL EFSC, respectively). The effect of EFSC on cells viability was tested by methylthiazolyldiphenyltetrazolium bromide(MTT) colorimetric assay. EFSC-mediated inhibition of LPS-induced production of pro-inflammatory mediators, such as nitrite oxide(NO) and interleukin-6(IL-6) were quantified and neuron-protection effect against microglia-mediated inflammation injury was tested by hoechst 33258 apoptosis assay and crystal violet staining assay. The expression of pro-inflammatory marker proteins was evaluated by Western blot analysis or immunofluorescence. Results: EFSC(200 and 400 mg/mL) reduced NO, IL-6, inducible nitric oxide synthase(iN OS) and cyclooxygenase 2(COX-2) expression in LPS-induced BV-2 cel s(P<0.01 or P<0.05). EFSC(200 and 400 mg/mL) reduced the expression of NO in LPS-induced primary microglia and astroglia(P<0.01). In addition, EFSC al eviated cel apoptosis and inflammation injury in neurons exposed to microglia-conditioned medium(P<0.01). The mechanistic studies indicated EFSC could suppress nuclear factor(NF)-κB phosphorylation and its nuclear translocation(P<0.01). The anti-inflammatory effect of EFSC occurred through suppressed activation of mitogen-activated protein kinase(MAPK) pathway(P<0.01 or P<0.05). Conclusion: EFSC acted as an anti-inflammatory agent in LPS-induced glia cel s. These effects might be realized through blocking of NF-κB activity and inhibition of MAPK signaling pathways. 展开更多
关键词 neuroinflammation microglia Fructus Schisandrae chinensis nuclear factor-κB mitogen- activated protein kinase
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五味子诱导下珊瑚状猴头菌GABA合成调控机理研究 认领 引用
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作者 张疏雨 郭玲玲 +4 位作者 柴林山 关艳丽 朱万芹 李剑梅 谢存一 《微生物学杂志》 CAS CSCD 北大核心 2026年第3期73-90,共18页
挖掘五味子(Schisandra chinensis(Turcz.)Baill.)诱导环境下珊瑚状猴头菌(Hericium coralloides)在不同生长阶段产生γ-氨基丁酸(γ-aminobutyric acid,GABA)过程中基因的表达。以珊瑚状猴头菌RT25为研究对象,通过设置五味子实验组和... 挖掘五味子(Schisandra chinensis(Turcz.)Baill.)诱导环境下珊瑚状猴头菌(Hericium coralloides)在不同生长阶段产生γ-氨基丁酸(γ-aminobutyric acid,GABA)过程中基因的表达。以珊瑚状猴头菌RT25为研究对象,通过设置五味子实验组和对照组,对比分析了五味子诱导下菌株RT25菌丝体生长状态及原基、子实体各项指标,利用转录组学技术分析菌株RT25在不同生长发育阶段的差异基因表达及相关富集途径。研究结果表明,与对照组相比,五味子实验组菌株RT25发酵液菌球表现出更高的均匀性与密度;实验组菌株RT25菌丝生长速率、原基形成及生物学效率等指标均显著提升;转录组研究结果表明,在菌株RT25菌丝体发酵阶段,五味子通过上调菌株RT25 DN344基因表达,增强谷氨酸脱氢酶活性,使L-谷氨酸水平升高,从而促进GABA含量增加;在原基形成期,五味子诱导菌株RT25 DN3464基因表达上调,提高谷氨酸脱羧酶活性,进而提升GABA的生物合成效率;在子实体成熟期,菌株RT25 DN344基因表达上调,谷氨酸脱氢酶活性增强,L-谷氨酸含量增加,而DN3464基因表达水平及谷氨酸脱羧酶活性保持稳定,γ-氨基丁酸转氨酶活性增强,最终使菌株RT25 GABA含量上升。五味子通过调控菌株RT25细胞内的信号传导通路,影响其GABA合成相关基因的表达,进而调节其GABA代谢通路相关酶的活性,促进谷氨酸向GABA转化,最终提高GABA的产量。 展开更多
关键词 珊瑚状猴头菌(Hericium coralloides) 五味子(Schisandra chinensis(Turcz.)Baill.) γ-氨基丁酸 转录组 调控机理
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药用植物提取物五味子乙素促进有氧运动中的脂肪代谢研究 认领 引用 被引量：1
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作者 刘理丹 程音 吴晓伟 《分子植物育种》 CAS 北大核心 2025年第2期583-592,共10页
本研究旨在探讨药用植物提取物五味子乙素(Schisandrin B,Sch B)与有氧运动联合干预对肥胖大鼠脂肪代谢的调节作用。通过建立高脂饮食诱导的肥胖大鼠模型,分析五味子乙素在不同剂量(50,100,200 mg/kg)联合有氧运动对体重、血清脂代谢指... 本研究旨在探讨药用植物提取物五味子乙素(Schisandrin B,Sch B)与有氧运动联合干预对肥胖大鼠脂肪代谢的调节作用。通过建立高脂饮食诱导的肥胖大鼠模型,分析五味子乙素在不同剂量(50,100,200 mg/kg)联合有氧运动对体重、血清脂代谢指标、肝脏脂质积累、氧化应激、炎症反应及脂代谢相关基因表达的影响。结果表明,五味子乙素与有氧运动联合使用显著降低了肥胖大鼠的体重,纠正了血清脂质代谢异常,减少了肝脏脂质积累。此外,五味子乙素显著提高了肝脏中抗氧化酶SOD、GSH-Px和CAT的活性,降低了MDA含量,减轻了氧化应激反应。同时,五味子乙素与有氧运动结合显著抑制了肝脏炎症因子TNF-α、IL-1β和IL-6的表达,并通过激活AMPK信号通路,调节脂代谢基因C/EBPα、SREBP1c、ACC、FAS和CPT1α的转录,促进脂肪酸氧化,抑制脂肪生成。该研究表明,五味子乙素与有氧运动的协同作用能够有效改善肥胖引发的代谢紊乱,具有潜在的临床应用价值。 展开更多
关键词 药用植物提取物 五味子(Schisandra chinensis) 五味子乙素 肥胖 有氧运动 AMPK 脂肪代谢
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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism 认领 引用
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作者 Shi-Bo Feng Hai-Hui Jiang +7 位作者 Hui-Li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng 《Traditional Medicine Research》 2025年第1期27-43,共17页
Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a signifi... Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic effect.Therefore,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was explored.Methods:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood glucose.Triglyceride,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were observed.The 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal flora.Based on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was analyzed.Results:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control group.And SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric acid.Conclusion:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in rats.SDP against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids. 展开更多
关键词 Schisandra sphenanthera T2DM intestinal flora HPLC
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Chemical constituents from the fruit of Schisandra Chinensis 认领 引用 被引量：4
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作者 Yunling Xu Yuji Wang +4 位作者 Shiping Jiang Tingting Cai Nannan Wang Xia Liu Wanping Zhu 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2020年第7期480-486,共7页
A new 18-norschiartane bisnortriterpenoid,12-angeloyl wuweizidilactone I(1)and nine known compounds,wuweizidilactone I(2),wuweizidilactone G(3),deoxychizandrin(4),sasanquin(5),orcinol-O-β-D-glucopyranoside(6),okanin-... A new 18-norschiartane bisnortriterpenoid,12-angeloyl wuweizidilactone I(1)and nine known compounds,wuweizidilactone I(2),wuweizidilactone G(3),deoxychizandrin(4),sasanquin(5),orcinol-O-β-D-glucopyranoside(6),okanin-4-methyl ether-3’-O-β-Dglucopyranoside(7),evemic acid(8),juglansol A(9)and 2-acetoxybenzyl benzoate(10),were isolated from the fruits of Schisandra Chinensis.Their structures were established by a combination of spectroscopic data analysis in addition to comparison with literature data.Compound 1 was new,and compounds 6–10 were isolated from Schisandrae Chinensis for the first time. 展开更多
关键词 Schisandrae Chinensis Wuweizidilactone Structural identification
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南五味子不同溶剂提取物的抑菌活性研究 认领 引用 被引量：4
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作者 王少杰 杨敏 于新 《安徽农业科学》 CAS 2013年第5期1922-1924,共3页
[目的]研究南五味子的乙醇提取物和水提取物的抑菌活性。[方法]分离南五味子提取物中的乙醇相物质和水相物质,用牛津杯法测定其对常见的致病菌和酵母菌的抑菌活性,用平板涂布法测定最低抑菌浓度(MIC)和最低杀菌浓度(MBC)。[结果]南五味... [目的]研究南五味子的乙醇提取物和水提取物的抑菌活性。[方法]分离南五味子提取物中的乙醇相物质和水相物质,用牛津杯法测定其对常见的致病菌和酵母菌的抑菌活性,用平板涂布法测定最低抑菌浓度(MIC)和最低杀菌浓度(MBC)。[结果]南五味子的醇相和水相物质对革兰氏阳性菌(G+)和革兰氏阴性菌(G-)均有明显的抑菌活性,对G+的抑菌活性均强于对G-的抑菌活性;醇相的抑菌活性优于水相的抑菌活性;对酵母菌的抑菌活性均不明显;醇相和水相的抑菌活性顺序均依次为:金黄色葡萄球菌>枯草芽孢杆菌>大肠杆菌>沙门氏菌>酵母菌。[结论]南五味子的乙醇提取物和水提取物均有一定的抑菌活性,值得进一步开发利用。 展开更多
关键词 南五味子(FRUCTUS SCHISANDRAE SPHENANTHERAE) 乙醇相和水相 最低抑菌浓度 最低杀菌浓度
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珍枣安神胶囊中五味子的提取工艺研究 认领 引用 被引量：1
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作者 杨丽 李庆杰 +1 位作者 王莲萍 刘永强 《安徽农业科学》 CAS 2012年第9期5164-5164,5201,共1页
[目的]优选珍枣安神胶囊中五味子的最佳提取工艺。[方法]以五味子醇甲为考察指标,以乙醇浓度、提取时间、料液比和提取次数为考察因素,应用L9(34)正交试验优选五味子的最佳提取工艺。[结果]五味子最佳提取工艺条件为:料液比1∶10(g/ml)... [目的]优选珍枣安神胶囊中五味子的最佳提取工艺。[方法]以五味子醇甲为考察指标,以乙醇浓度、提取时间、料液比和提取次数为考察因素,应用L9(34)正交试验优选五味子的最佳提取工艺。[结果]五味子最佳提取工艺条件为:料液比1∶10(g/ml),煎煮3次,每次1.5 h;在此条件下,珍枣安神胶囊中五味子醇甲平均得率为5.05 mg/g。[结论]优选出了珍枣安神胶囊中五味子的最佳提取工艺条件,该提取工艺简便可行。 展开更多
关键词 五味子(FRUCTUS SCHISANDRAE CHINENSIS) 正交设计
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栽培五味子与野生五味子的品质评价 认领 引用 被引量：1
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作者 葛会奇 楚冬海 颜廷才 《安徽农业科学》 CAS 2012年第29期14242-14243,共2页
[目的]通过对栽培五味子与野生五味子的部分理化指标进行测定,对两者进行品质综合评价。[方法]采用HPLC法测定木脂素的含量,用费林氏试剂法测定总糖的含量,并用酸碱滴定法测定总酸的含量,以分光光度计法测定色价,并以高锰酸钾氧化法测... [目的]通过对栽培五味子与野生五味子的部分理化指标进行测定,对两者进行品质综合评价。[方法]采用HPLC法测定木脂素的含量,用费林氏试剂法测定总糖的含量,并用酸碱滴定法测定总酸的含量,以分光光度计法测定色价,并以高锰酸钾氧化法测定鞣质的含量,用紫外-可见光分光光度计法测定主要无机元素P的含量,并用原子吸收分光光度计法测定K、Fe、Zn和Cu的含量。[结果]栽培品种在总酸、总糖以及色价指标上明显高于野生品,而栽培品种和野生品中鞣质的含量没有太大的差异。4个栽培品种中1号质量最好,4号的质量较差。4个栽培品种五味子的五味子醇甲、五味子甲素和五味子乙素的含量均明显高于野生品,1号和3号五味子质量较好,而在粗蛋白和粗灰分的含量上,栽培品和野生品没有太大的区别。在栽培品和野生品中检测出7种人体必需氨基酸(色氨酸未检出),在野生品中未检测出半胱氨酸,其中1号样品氨基酸含量较高,而野生品含量最低。栽培品五味子在无机元素(Fe、Zn、Cu、P、K和Mg)的含量指标上均高于野生品。4个栽培品种中,Cu、P和K在1号中的含量最高,Fe和Mg在3号中的含量最高,Zn在4号中的含量最高。[结论]综合各种检测指标表明,栽培品五味子的品质优于野生五味子。 展开更多
关键词 五味子(FRUCTUS SCHISANDRAE CHINENSIS) 栽培品 野生品 品质评价
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Simultaneous qualitative identification of all medicinal herbs in Zaoren Anshen capsule by thin-layer chromatography 认领 引用 被引量：1
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作者 Manjiang Xie Jie Wang +2 位作者 Chenguang Dong Pengfei Tu Qingying Zhang 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2022年第7期499-506,共8页
The holistic characterization and quality control of all the medicinal herbs of proprietary Chinese medicines(PCMs)are of great significance to ensure their safety,efficacy,and consistency.Thin-layer chromatography(TL... The holistic characterization and quality control of all the medicinal herbs of proprietary Chinese medicines(PCMs)are of great significance to ensure their safety,efficacy,and consistency.Thin-layer chromatography(TLC),a simple and classic approach for qualitatively characterizing and examining quality markers of natural products,has been widely used in the characterization and quality control of traditional Chinese medicines.Zaoren Anshen(ZRAS)capsule,prepared from three medicinal herbs of fried Ziziphi Spinosae Semen,Salvia Miltiorrhiza Radix et Rhizoma,and vinegar-processed Schisandrae Chinensis Fructus,is a famous PCM in China for the treatment of insomnia,amnesia,and dizziness in clinical practice.However,no effective method is available so far for simultaneous identification and examination of all the three medicinal herbs of ZRAS capsule.In the present study,we developed a TLC method via twice-development and visualization by UV light or chromogenic agent,which could be used for simultaneous qualitative identification of all the three medicinal herbs of ZRAS capsule in one plate.Moreover,the sample preparation method was optimized.The developed TLC method was rapid,simple,low-cost,and effective,and thus it could be used for quality control of ZRAS capsule. 展开更多
关键词 Zaoren Anshen capsule Ziziphi Spinosae Semen Salviae Miltiorrhizae Radix et Rhizoma Schisandrae Chinensis Fructus Thin-layer chromatography Qualitative identification
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Targeted bile acids and gut microbiome profiles reveal the hepatoprotective effect of WZ tablet(Schisandra sphenanthera extract) against LCA-induced cholestasis 认领 引用 被引量：14
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作者 LI Dong-Shun HUANG Quan-Fei +7 位作者 GUAN Li-Huan ZHANG Hui-Zhen LI Xi FU Kai-Li CHEN Yi-Xin WAN Jian-Bo HUANG Min BI Hui-Chang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2020年第3期211-218,共8页
Cholestasis is caused by the obstacle of bile formation or secretion and can develop into severe liver diseases. We previously reported the ethanol extract of Schisandra sphenanthera(Wuzhi tablet, WZ) can significantl... Cholestasis is caused by the obstacle of bile formation or secretion and can develop into severe liver diseases. We previously reported the ethanol extract of Schisandra sphenanthera(Wuzhi tablet, WZ) can significantly protect against lithocholic acid(LCA)-induced intrahepatic cholestasis in mice, partially due to the activation of PXR pathway and promotion of liver regeneration.However, the effect of WZ on the bile acids profile and gut microbiome in cholestastic mice remain unknown. In this study, the effect of WZ against LCA-induced liver injury was evaluated and its effect on the bile acids metabolome and gut microbiome profiles in cholestastic mice was further investigated. Targeted metabolomics analysis was performed to examine the change of bile acids in the serum, liver, intestine and feces. The change of intestinal flora were detected by the genomics method. Targeted metabolomics analysis revealed that WZ enhanced the excretion of bile acids from serum and liver to intestine and feces. Genomics analysis of gut microbiome showed that WZ can reverse LCA-induced gut microbiome disorder to the normal level. In conclusion, WZ protects against LCAinduced cholestastic liver injury by reversing abnormal bile acids profiles and alteration of gut microbiome. 展开更多
关键词 Cholestasis Wuzhi tablet Schisandra sphenanthera Metabolome Gut microbiome Bile acids
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Protective effects of extracts of Schisandra chinensis stems against acetaminophen-induced hepatotoxicity via regulation of MAPK and caspase-3 signaling pathways 认领 引用 被引量：14
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作者 LI Yan-Zi Ma Zhi-Na +5 位作者 SUN Yin-Shi REN Shen JIANG Shuang ZHANG Wei-Zhe WANG Zi LI Wei 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2018年第9期700-713,共14页
The present study was designed to evaluate protective activity of an ethanol extract of the stems of Schisandra chinensis(SCE) and explore its possible molecular mechanisms on acetaminophen(APAP) induced hepatotoxicit... The present study was designed to evaluate protective activity of an ethanol extract of the stems of Schisandra chinensis(SCE) and explore its possible molecular mechanisms on acetaminophen(APAP) induced hepatotoxicity in a mouse model. The results of HPLC analysis showed that the main components of SCE included schisandrol A, schisandrol B, deoxyschisandrin, schisan--drin B, and schisandrin C and their contents were 5.83, 7.11, 2.13, 4.86, 0.42 mg·g-1, respectively. SCE extract was given for 7 con--secutive days before a single hepatotoxic dose of APAP(250 mg·kg-1) was injected to mice. Our results showed that SCE pretreatment ameliorated liver dysfunction and oxidative stress, which was evidenced by significant decreases in aspartate transaminase(AST), alanine aminotransferase(ALT), malondialdehyde(MDA) contents and elevations in reduced glutathione(GSH) and superoxide dismutase(SOD) levels. These findings were associated with the result that the SCE pretreatment significantly decreased expression levels of 4-hydroxynonenal(4-HNE) and 3-nitrotyrosine(3-NT). SCE also significantly decreased the expression levels of Bax, mitogen-activated protein kinase(MAPK), and cleaved caspase-3 by APAP exposure. Furthermore, supplementation with SCE suppressed the expression levels of inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2), suggesting alleviation of inflammatory response. In summary, these findings from the present study clearly demonstrated that SCE exerted significant alleviation in APAP-induced oxidative stress, inflammation and apoptosis mainly via regulating MAPK and caspase-3 signaling pathways. 展开更多
关键词 Schisandra chinensis APAP-induced hepatotoxicity Anti-oxidation Anti-inflammation Anti-apoptosis MAPK and caspase-3 signaling pathways
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