Thrombotic thrombocytopenic purpura(TTP) is a rare hematological disorder classically characterized by a triad of symptoms: thrombocytopenia, microangiopathic hemolytic anemia, and neurological impairment. The presenc...Thrombotic thrombocytopenic purpura(TTP) is a rare hematological disorder classically characterized by a triad of symptoms: thrombocytopenia, microangiopathic hemolytic anemia, and neurological impairment. The presence of fever and renal injury, together with the triad, constitute the less common but classic pentad. Secondary TTPs, particularly infection-associated TTPs, are even rarer.[1] Herein, we report a case of secondary TTP following a severe infection.展开更多
Although the concentration of fine particulate matter(PM2.5)is reducing continuously,the proportion of secondary organic aerosols(SOA)in PM2.5 and the O3 levels are increasing.This is causing severe complex a...Although the concentration of fine particulate matter(PM2.5)is reducing continuously,the proportion of secondary organic aerosols(SOA)in PM2.5 and the O3 levels are increasing.This is causing severe complex atmospheric pollution in North China.It is essential to identify and quantify the driving factors of SOA and O3,including the various pollution sources and meteorological factors.PM2.5 and volatile organic compounds(VOCs)samples were collected simultaneously in three cities in Shandong Province during different pollution scenarios from 2021 to 2023.Then,the carbonaceous aerosol and 99 VOC species were analyzed.Random forest(RF)combined with positive matrix factorization and an observation-based model(OBM)were used to quantify the key drivers of SOA and O3.Aromatic hydrocarbons were the main contributors to secondary organic aerosol potential(74.3%-89.9%),whereas alkenes contributed the most to the ozone formation potential(27.0%-62.3%).The RF modeling identified temperature and NOx as the dominant drivers of ozone formation.These accounted for 47.8%and 17.4%,respectively.Temperature showed a positive correlation with O3 because an increase in temperature can promote ozone formation.NOx had a significant negative correlation with O3,which was consistent with the conclusions from the sensitivity analysis of the OBM.The dominant contributors to SOA were vehicle emissions,solvent use,and industrial emissions.These accounted for 43.9%,18.2%,and 10.5%,respectively.An evident positive correlation existed between these emission sources and SOA.展开更多
Titanium is widely regarded as a strategically important metal due to its outstanding properties and broad applications in metallurgy,aerospace,and energy sectors.However,with the gradual depletion of primary titanium...Titanium is widely regarded as a strategically important metal due to its outstanding properties and broad applications in metallurgy,aerospace,and energy sectors.However,with the gradual depletion of primary titanium ores,concerns over long-term supply security are becoming increasingly prominent.At present,less than 20%of titanium-bearing secondary resources are effectively utilized,while the majority are either stockpiled or discarded,resulting in both significant resource loss and environmental challenges.A comprehensive review of six representative titanium-bearing secondary resources,which were either derived from titanium production processes or contain relatively high levels of titanium,was conducted.These resources included titanium-bearing blast furnace slag,titanium-extracted tailings,ferrotitanium slag,titanium gypsum,spent selective catalytic reduction catalysts,and red mud.The chemical and mineralogical characteristics,utilization pathways,and underlying reaction mechanisms were systematically summarized.Particular attention was given to recent advances in extraction technologies for titanium recovery from these materials.From a practical standpoint,classifying and recycling these resources according to their intrinsic physicochemical properties could enable more targeted and efficient recovery strategies.Meanwhile,the development of low-carbon or carbon-neutral extraction technologies,together with environmentally benign leaching processes,remains highly desirable.Additionally,the integration of intelligent management systems for monitoring energy consumption,environmental impact,and economic performance will play a crucial role in advancing the sustainable utilization of titanium-bearing resources.展开更多
Accurate in-situ identification of coal and gangue is critical for intelligent mining,particularly in longwall top coal caving(LTCC)mining,where it enables precise control of the gangue mixed ratio and enhances resour...Accurate in-situ identification of coal and gangue is critical for intelligent mining,particularly in longwall top coal caving(LTCC)mining,where it enables precise control of the gangue mixed ratio and enhances resource recovery.This study introduces a Secondary Intervention strategy to augment the conventional“liquid intervention+infrared detection”approach.Results demonstrate that Secondary Intervention can consistently enhance the thermal contrast between coal and gangue,and the average accuracy of infrared image recognition for coal and gangue increased from 79.14%after the First Intervention to 93.75%after the Secondary Intervention,representing an improvement of 14.61%.Furthermore,the average contact angle difference between coal and gangue expanded from 16.64°after the First Intervention to 33.80°after the Secondary Intervention,an increase of 17.16°.Meanwhile,the area difference between coal and gangue increased by 4.94 times.Moreover,based on comprehensive analysis of the temperature difference,accuracy of morphological identification,as well as the contact angle and area of droplets,the eco-friendly compound surfactant(EFCS)of Soapnut Saponin(SS)+CTAB with a concentration of0.06 wt%demonstrated optimal performance.These findings advance liquid intervention techniques for infrared-based recognition and support the development of greener,more intelligent coal production systems.展开更多
Understanding public conservation willingness is crucial for mitigating the global decline in avian diversity.Secondary school students,as key future actors and stakeholders in biodiversity conservation,represent a cr...Understanding public conservation willingness is crucial for mitigating the global decline in avian diversity.Secondary school students,as key future actors and stakeholders in biodiversity conservation,represent a critical demographic,but their conservation willingness toward avian species remains largely underexplored.To address this gap,we conducted a questionnaire survey in 64 secondary schools across eight riparian cities along the Yellow River in Henan Province,China.Using the Great Bustard(Otis tarda)—a national first-class protected species and local conservation flagship—as the focal species,we constructed piecewise structural equation models(SEMs)to identify the key factors influencing students'conservation willingness.The questionnaire results revealed that although nearly 90%of students supported the Great Bustard conservation,only about 30%understood both its protection class and habitat characteristics,and less than half had relevant nature experience or had participated in local forestry departments'science communication activities.The piecewise SEM results demonstrated that students'interest in birds,knowledge level of the Great Bustard,and participation in science communication activities all exerted direct and significant positive influences on their conservation willingness.In addition to its direct effect,science communication engagement also indirectly enhanced conservation willingness by strengthening interest and knowledge,while the effects of grade level and nature experience were exclusively indirect,operating through the same pathways.To improve the effective conservation of the Great Bustard,we recommend that secondary schools strengthen collaborations with universities and nature reserves to enrich students'nature experience,and that local forestry departments further expand the coverage and depth of science communication activities targeting adolescent groups.展开更多
Implementing advanced nitrogen removal in wastewater treatment plants has emerged as a critical strategy to comply with tightening global nitrogen discharge mandates.To achieve advanced nitrogen removal under low-carb...Implementing advanced nitrogen removal in wastewater treatment plants has emerged as a critical strategy to comply with tightening global nitrogen discharge mandates.To achieve advanced nitrogen removal under low-carbon treatment conditions,pyrite-based mixotrophic denitrification(PMD)demonstrates promising application prospects.However,existing research predominantly focuses on synthetic wastewater in laboratory settings,with insufficient attention to practical applications using complex real wastewater.This study investigated PMD treating actual secondary effluent(TN:16-25 mg/L)from a full-scale wastewater treatment plant under natural aerobic conditions.Through optimized pyrite particle size(1.2-2.4 mm)and carbon-to-nitrogen ratio(C/N=3:1),PMD achieved 90.8%TN removal efficiency with effluent TN<2 mg/L,meeting stringent discharge standards.Under optimized conditions,oxygen boosted S2-/Fe2+release from pyrite.The 1.2-2.4 mm particles created micro-aerobic and micro-anaerobic niches,which facilitated synergistic symbiosis between autotrophic and heterotrophic denitrifiers.This microbial collaboration endowed the system with enhanced denitrification performance and improved filtration characteristics.The dominant bacterial genera in optimal conditions were unclassified_f_Rhodocyclaceae(22.4%),unclassified_f_Comamonadaceae(16.3%),and Thauera(5.9%),while nirK-type denitrifying bacteria dominated the denitrification in this system.This research offers valuable recommendations for developing an energy-efficient and low-carbon advanced nitrogen removal process in wastewater treatment facilities.展开更多
Elucidating the interplay between different volatile organic compounds(VOCs)is crucial for understanding the formation mechanisms of secondary organic aerosols(SOA).This study systematically investigated the interacti...Elucidating the interplay between different volatile organic compounds(VOCs)is crucial for understanding the formation mechanisms of secondary organic aerosols(SOA).This study systematically investigated the interactions between the bicyclic monoterpeneα-pinene and the monocyclic monoterpene limonene under NO2photooxidation and dark ozonolysis conditions.The results show that under the NO2photooxidation conditions,the increase of[limonene]0 enhances particle mass concentrations,number concentrations,and particle size;the increase of[α-pinene]0 results in the increase of particle mass and number concentrations without the increase of particle size.Under the dark ozonolysis conditions,particle mass and number concentrations increase with the increase of[α-pinene]0 and[limonene]0;the effect of increasing[α-pinene]0 on SOA mass concentration is significantly smaller than that of increasing[limonene]0,which may be attributed to the shift to a smaller particle size with the increase of[α-pinene]0.As the[limonene]0/[mixed VOCs]0 ratio increases from 0%to 100%,the SOA yield increases from 54.6%to 65.2%under the NO2photooxidation conditions and from 19.8%to 26.2%under the O3conditions.Using threshold photoionization mass spectrometry based on a vacuum ultraviolet free electron laser,a series of new products were detected at molecular weights of 364,366,380,386,411,413,and414,which could be assigned to the cross-dimers,such as organic peroxides,ester dimers,and organic nitrates.Our study underscores the critical role of monocylic monoterpene limonene in the SOA formation and advances our understanding of the SOA formation in the atmosphere.展开更多
Adolescent smoking constitutes a critical public health challenge as early initiation increases the risk of premature mortality and smoking-related chronic diseases due to longer exposure and higher cumulative tobacco...Adolescent smoking constitutes a critical public health challenge as early initiation increases the risk of premature mortality and smoking-related chronic diseases due to longer exposure and higher cumulative tobacco use[1].Adolescents are especially prone to developing persistent smoking habits,with many adult smokers having started before the age of 18.In China,16.7%of secondary school students have tried smoking and 4.7%are current smokers,highlighting the critical need for targeted tobacco control interventions among the youth.展开更多
OBJECTIVE:To assess the impact of body mass index(BMI)on the effectiveness of acupuncture in treating postprandial distress syndrome(PDS).METHODS:Data from 278 patients enrolled in a prior multicenter,randomized,sham-...OBJECTIVE:To assess the impact of body mass index(BMI)on the effectiveness of acupuncture in treating postprandial distress syndrome(PDS).METHODS:Data from 278 patients enrolled in a prior multicenter,randomized,sham-controlled trial were analyzed in this secondary study.Patients were classified into three groups according to baseline BMI:low,normal,and high.The primary outcome was the response rate after 4 weeks of treatment.The χ2 test was used to examine the effect of BMI on acupuncture efficacy.After multiple imputation for missing data,logistic regression analysis was performed to evaluate this association.A sensitivity analysis was conducted by combining the low and normal BMI groups.In addition,BMI was analyzed as a continuous variable using logistic regression to explore its relationship with treatment efficacy in the acupuncture group.RESULTS:The χ2 test revealed a statistically significant difference,with the acupuncture group demonstrating a markedly higher response rate than the sham group(82.91%vs 51.79%,χ2=25.34,P<0.001).In both the normal and high BMI categories,the response rate in the acupuncture group(82.91%)was higher than that in the sham acupuncture group(48.21%)(χ2=25.34,P<0.001).Following multiple imputation,logistic regression analysis demonstrated a significant overall association between BMI category and treatment response(P<0.001).Acupuncture showed superior efficacy compared with sham acupuncture[OR=1.97,95%CI(1.34,2.90),P<0.001].At week 4,response rates were 68.4%in the low BMI group,81.7%in the normal BMI group,and 96.3%in the high BMI group(χ2=6.303,P=0.043).A significant difference was observed only between the low and high BMI groups(χ2=6.717,P=0.010).Sensitivity analysis showed that the high BMI group achieved significantly better outcomes than the non-high BMI group in elimination rates at week 8 and week 12(χ2=4.571,P=0.033;χ2=4.589,P=0.032).Logistic regression analysis indicated that BMI was an independent predictor of response rate at week 4[OR=1.186,95%CI(1.010,1.394),P=0.038]and elimination rate at week 12[OR=1.126,95%CI(1.002,1.265),P=0.047],whereas no significant associations were observed at other follow-up points.CONCLUSION:This subgroup analysis indicated that acupuncture improved PDS symptoms across different BMI categories.Acupuncture was suggested as a viable therapeutic option for patients with PDS,particularly those with a higher BMI.展开更多
To determine how high temperature(HT)impairs cotton fiber elongation,greenhouse experiments compared two temperature regimes(CT,28℃HT,38℃)for 12 d.The findings indicated that compared with CT,the fiber elongation ra...To determine how high temperature(HT)impairs cotton fiber elongation,greenhouse experiments compared two temperature regimes(CT,28℃HT,38℃)for 12 d.The findings indicated that compared with CT,the fiber elongation rate initially increased during HT(0-8 d),but subsequently decreased,resulting in a significant decrease in cotton fiber length at harvest.At 3 and 6 d under HT,cell turgor pressure increased;additionally,the auxin and ethylene content in fiber significantly increased,promoting cell wall loosening and increasing elongation rate through regulating xyloglucan endoglycosyltransferases/hydrolases and expansin.At 12 d under HT,cellulose and hemicellulose decomposition were inhibited in fiber,which hindered cell wall loosening and restricted fiber elongation.Meanwhile,the lipid and callose content in fiber was increased,and the enhanced abscisic acid and H2O2content promoted lignin synthesis by up-regulating the expression of WLIM1a gene.Both changes accelerated the initiation of secondary wall synthesis.Consequently,the transition stage that coincides with fiber elongation and secondary wall thickening was reduced by 0.3-0.5 d,leading to a decrease in fiber length.In summary,fiber length was reduced under HT,accompanied by restricted cell wall loosening and accelerated secondary wall synthesis.展开更多
AIM:To investigate the etiology and clinical characteristics of hospitalized secondary glaucoma(SG)patients in northwestern China.METHODS:A cross-sectional study was conducted involving SG patients hospitalized betwee...AIM:To investigate the etiology and clinical characteristics of hospitalized secondary glaucoma(SG)patients in northwestern China.METHODS:A cross-sectional study was conducted involving SG patients hospitalized between July 2024 and January 2025.Clinical data were collected,including medical history,best-corrected visual acuity(BCVA),intraocular pressure(IOP),slit-lamp examination,gonioscopic findings,and fundus examination.Demographic characteristics,etiological factors,and treatment modalities were analyzed.RESULTS:A total of 67 patients(82 eyes)were enrolled,aged 7 to 90y.Males accounted for 54.0%(36/67),and 22.4%(15/67)of patients had bilateral involvement.The predominant etiologies of SG were neovascular glaucoma(NVG;25.4%),traumatic glaucoma(23.9%),uveitic glaucoma(20.9%),and lens-induced glaucoma(14.9%),collectively accounting for 85.1%of all cases.The peak age-specific incidence occurred in the 50-59 years age group(32.8%,22/67),while NVG was prevalent across the 40-79 years age range.IOP of the 82 affected eyes was stratified into five severity tiers:22-29 mm Hg(15 eyes,18.3%),30-39 mm Hg(14 eyes,17.1%),40-49 mm Hg(13 eyes,15.9%),50-59 mm Hg(20 eyes,24.4%),and≥60 mm Hg(20 eyes,24.4%).The overall mean IOP was 45.2±12.3 mm Hg,indicating a significant pathological elevation.Surgical intervention was required in 46.3%of cases,predominantly for NVG,lensinduced glaucoma,and traumatic glaucoma—conditions prone to rapid IOP elevation.The etiologies with the highest surgical intervention rates were malignant glaucoma,pigmentary glaucoma,lens-induced glaucoma,and NVG.In contrast,uveitic glaucoma cases were primarily managed with targeted anti-inflammatory therapy,which effectively controlled IOP in the early disease stages and potentially obviated the need for surgery.CONCLUSION:This study identifies NVG,traumatic glaucoma,uveitic glaucoma,and lens-induced glaucoma as the four leading etiologies of SG in Northwestern China.These findings emphasize the critical need for targeted prevention strategies and evidence-based health education programs among high-risk populations.Implementation of such initiatives will improve early detection,enable ophthalmologists to deliver timely therapeutic interventions,and ultimately reduce preventable vision loss in this region.展开更多
Synergistic sulfidation roasting of heavy metal gypsum residue and secondary zinc oxide fume was proposed by using the research idea of“waste to treat waste”.Thermodynamic studies indicated that the sulfidation of z...Synergistic sulfidation roasting of heavy metal gypsum residue and secondary zinc oxide fume was proposed by using the research idea of“waste to treat waste”.Thermodynamic studies indicated that the sulfidation of zinc oxide could be effectively enhanced by increasing the dosage of calcium sulfate and carbon powder in the range of 500-800℃.The synergistic sulfidation experiments of heavy metal gypsum residue with secondary zinc oxide showed that the sulfidation rate of zinc reached 90.39% and the grain size of ZnS increased from 5 to 10μm under the conditions of temperature 700℃,carbon powder 30%,Na2CO310%,mass ratio of gypsum residue to secondary zinc oxide 1.4꞉1,roasting time 2 h and cooling rate 1℃/min.Meanwhile,76.32%F,72.11%Cl and 93.41%As were removed.TG/DTG-DSC,3D FTIR spectra and SEM analysis showed that the conversion of CaSO4 to CaCO3 and the avoidance of CO2 and SO2 production were achieved under optimized conditions.This study achieves efficient sulfidation of zinc as well as growth of ZnS grains,laying the theoretical and technological foundation for subsequent recovery of ZnS by flotation.展开更多
Cotton fiber provides an exceptional model system for studying plant cell differentiation,elongation,and cell wall biogenesis.Recent advances in genomics,single-cell transcriptomics,genome editing,and multi-omics appr...Cotton fiber provides an exceptional model system for studying plant cell differentiation,elongation,and cell wall biogenesis.Recent advances in genomics,single-cell transcriptomics,genome editing,and multi-omics approaches have dramatically expanded our understanding of the molecular networks governing cotton fiber development.This review synthesizes current knowledge on the transcriptional,hormonal,epigenetic,and metabolic regulation of fiber initiation,elongation,and secondary cell wall(SCW)formation.We highlight the central roles of key transcription factors families—including MYB,HD-ZIP,bHLH,and NAC—in coordinating fiber cell fate determination and morphogenesis.We further discuss how phytohormones such as auxin,gibberellins,brassinosteroids,and strigolactones interact to regulate fiber elongation and SCW deposition.Emerging evidence also indicates that epigenetic mechanisms,including chromatin accessibility and RNA methylation,contribute to the fine-tuning of stage-specific gene expression.Furthermore,we explore how cytoskeletal dynamics and lipid metabolism contribute to polarized cell growth.Finally,we assess the potential of CRISPR-Cas9-mediated gene editing for cotton fiber improvement and propose future research directions aimed at bridging knowledge gaps between molecular mechanisms and agronomic traits.Despite these advances,several knowledge gaps remain,including the precise integration of hormonal hierarchies,the functional validation of predicted regulatory modules in polyploid cotton,and the translational feasibility of gene editing for fiber quality improvement under field conditions.展开更多
In the implementation of the fundamental task of fostering virtue through education, mental health education delivered by secondary vocational class teachers serves as a core measure to expand the coverage of psycholo...In the implementation of the fundamental task of fostering virtue through education, mental health education delivered by secondary vocational class teachers serves as a core measure to expand the coverage of psychological services and build a full-scenario psychological education network. At present, the practical work faces multiple dilemmas: ambiguous power and responsibility boundaries for class teachers undertaking psychological education, low integration between mental health education and routine class management, inadequate targeted supply of tiered and categorized psychological services, and prominent deficiencies in supporting guarantee systems. In response, secondary vocational schools should clarify the power and responsibility list for class teachers’ psychological education and define the prohibited work scope, establish an integration mechanism linking mental health education with class management, construct a tiered and categorized psychological service supply system, and improve supporting modules including training and supervision, risk sharing, and performance incentives, so as to fully activate the psychological education capacity of class teachers.展开更多
Secondary metabolites play fundamental roles in apple,influencing the interaction with pollinators and frugivores for seed dispersal,contributing to fruit quality and promoting human health through their antioxidant p...Secondary metabolites play fundamental roles in apple,influencing the interaction with pollinators and frugivores for seed dispersal,contributing to fruit quality and promoting human health through their antioxidant property.Domestication and breeding have significantly re-shaped the apple metabolism,altering both aromatic profiles and nutritional properties.This study assessed the secondary metabolite variation in a comprehensive Malus spp.collection comprising 163 accessions belonging to 44 species.The profiling of phenolic and volatile organic compounds(VOCs),performed with Ultra-Performance Liquid Chromatography(UPLC)and Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry(PTR-ToF-MS)instruments respectively,in both skin and pulp tissues,uncovered distinct metabolic patterns between wild and domesticated apples.This investigation underlined the higher concentration of these metabolites in the skin tissue and revealed a clear metabolic divergence between the two groups of Malus accessions.Wild Malus spp.accessions resulted particularly rich in specific polyphenols characterized by antioxidant activity,including catechin and procyanidins.Conversely,apples of Malus domestica accessions exhibited a more abundant VOC profile,particularly represented by esters associated with fruity aroma,enhancing sensory appeal.These findings provide a foundation for leveraging wild germplasm in breeding programs,and the identification of accessions with high polyphenolic concentration and desirable aromatic profiles offers valuable opportunities to improve the aromatic and nutraceutical properties of apple.展开更多
Ni-Co-Mn-Ti alloys have become one of the most promising magnetic refrigeration materials due to their large magnetocaloric effect.However,magnetic hysteresis during magnetization and demagnetization cycles leads to c...Ni-Co-Mn-Ti alloys have become one of the most promising magnetic refrigeration materials due to their large magnetocaloric effect.However,magnetic hysteresis during magnetization and demagnetization cycles leads to considerable loss of hysteresis,thereby reducing the refrigeration capacity.Here,we report that the introduction of the rare-earth element Sc,leading to the formation of a secondary phase,significantly reduces the hysteresis loss in Ni-Co-Mn-Ti alloys.In the Ni37Co13Mn35Ti15-xScx(x=0,1.25,1.5,2)alloys,as the Sc content increases,the magnetic entropy change gradually decreases,while the refrigeration temperature range steadily broadens,and the magnetic hysteresis loss significantly reduces.When the Sc content reaches x=2,the magnetic hysteresis loss drops to 29.3 J/kg,representing an 70%reduction compared to the undoped sample(97.75 J/kg).Therefore,although the magnetic entropy change decreases,the substantial reduction in hysteresis loss and the expansion of the refrigeration temperature range lead to a reverse growth of the effective refrigerant capacity(RCeff).At the same time,the introduction of the second phase also leads to a significant improvement in mechanical properties.These findings suggest that introducing a secondary phase through Sc doping is an effective strategy for reducing hysteresis losses,making Ni-Co-Mn-Ti alloys a promising material system for magnetic refrigeration.展开更多
Atmospheric oxidation capacity(AOC)refers to the oxidation capacity of atmospheric chemical processes for major pollutants.A comprehensive observation campaign was conducted on a typical PM2.5pollution event in Uru...Atmospheric oxidation capacity(AOC)refers to the oxidation capacity of atmospheric chemical processes for major pollutants.A comprehensive observation campaign was conducted on a typical PM2.5pollution event in Urumqi,Northwest China,from January 15 to February 15,2024.Four typical cases representing PM2.5levels from non-polluted to heavily polluted periods were selected to estimate AOC,OH reactivity,their relationship with secondary components,and the HOxbudget in PM2.5using the Framework for 0-D Atmospheric Modeling model.Aromatics and alkanes contributed 54%-79%and 18%-46%of secondary organic aerosols(SOA)formation,respectively.The sulfur oxidation ratio(SOR)and nitrogen oxidation ratio(NOR)increased with rising PM2.5levels.As AOC increased,SOR showed the same trend,while NOR and SOA decreased slightly,and ammonia oxidation ratio values remained almost unchanged.OH radicals were the primary oxidants during the daytime,whereas NO3played a dominant role at nighttime.CO(24%-51%),NO2(27%-34%),and alkenes(7%-12%)were the dominant contributors to OH reactivity.The HO2+NO reaction pathway contributes 67%-84%to the production of OH,while Others(including carbonyl compounds photolysis,the permutation reactions of RO2,etc.),RO2+NO and OH+CO reaction pathways were the main pathways for HO2 production.A comprehensive understanding of the interactions among AOC,SOA,and radical cycling is crucial for formulating effective air quality management strategies aimed at mitigating secondary pollution under diverse atmospheric conditions.展开更多
new heterocyclic dipeptide with a highly functionalized 1,2-oxazadecaline core,named trichodermamide H(1),and three known analogues,along with three known polyketides,were isolated from the fermentation extract of the...new heterocyclic dipeptide with a highly functionalized 1,2-oxazadecaline core,named trichodermamide H(1),and three known analogues,along with three known polyketides,were isolated from the fermentation extract of the mangrovederived fungus Penicillium janthinellum XLN32122.The structure of 1 was elucidated on the basis of extensive 1D and 2D NMR spectra data analysis,HR-ESI-MS,electronic circular dichroism(ECD)calculations.Trichodermamide B(3)exhibited better inhibitory effect on nitric oxide(NO)production in lipopolysaccharide(LPS)induced RAW 264.7 cells with an IC50value of(13.13±0.005)μmol/L than that of the positive control dexamethasone[IC50=(136.84±1.33)μmol/L].Compound 3 exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus(MRSA)with an IC50value of 12.5μg/mL,while the positive control vancomycin showed an IC50value of 1.563μg/mL.展开更多
Biogenic volatile organic compounds(BVOCs),particularly terpenes,represent the dominant global source of secondary organic aerosols(SOA).However,the crucial investigation in terpene mixture under various nitrogen oxid...Biogenic volatile organic compounds(BVOCs),particularly terpenes,represent the dominant global source of secondary organic aerosols(SOA).However,the crucial investigation in terpene mixture under various nitrogen oxides(NOx)conditions needs to be further explored.To comprehensively understand the mixed SOA composition and its associated health effects,we simulated the mixed oxidation of α-pinene and isoprene in a smog chamber under various NOxconditions to investigate SOA formation and its related health effects.We found that increasing NOxlevels led to the formation of CHON compounds,suppressing functionalized products and oligomers.Results of the oxidative potential and total peroxides of SOA showed that mixed SOA had combined redox characteristics(isoprene SOA>mixed SOA>α-pinene SOA).The oxidative potential of isoprene SOA decreased as NOxincreased,whileα-pinene SOA was slightly affected.Results from iodometry combined with mass spectrometry indicated that hydrogen peroxides(ROOH)in highly oxygenated molecules played a crucial role in SOA health effects.NOxwas found to influence the production of ROOH by interfering with the RO2+HO2and RO2isomerization pathways.These results indicate that the reactive intermediate components in BVOC mixture under various NOxconditions are important factors influencing health effects of aerosol.展开更多
Effective use of brain-computer interfaces(BCIs)requires the ability to suppress a planned action(volitional inhibition)for adaptable control in real-world scenarios,but their mechanisms are unclear.Here,we used fiber...Effective use of brain-computer interfaces(BCIs)requires the ability to suppress a planned action(volitional inhibition)for adaptable control in real-world scenarios,but their mechanisms are unclear.Here,we used fiber photometry to monitor external globus pallidus(GPe)and subthalamic nucleus(STN)neurons’activity in mice during a volitional stop-signal task(67%GO,33%NO-GO).GPe/STN neurons(receiving M2 projections)responded to auditory cues,feedback,and rewards in both trials.Importantly,chemogenetic activation of the M2-GPe pathway enhanced volitional inhibition by modulating auditory feedback response,yet inhibited GPe neurons’feedback response.Furthermore,time-locked optogenetic inhibition of M2-projecting GPe neurons at auditory feedback also enhanced volitional inhibition via prolonged GO trial response times.Collectively,these findings identified the M2-GPe pathway for auditory biofeedback to improve volitional control,offering novel avenues for the advancement of neural interfaces for biofeedback and enhancement of BCI efficacy.展开更多
摘要Thrombotic thrombocytopenic purpura(TTP) is a rare hematological disorder classically characterized by a triad of symptoms: thrombocytopenia, microangiopathic hemolytic anemia, and neurological impairment. The presence of fever and renal injury, together with the triad, constitute the less common but classic pentad. Secondary TTPs, particularly infection-associated TTPs, are even rarer.[1] Herein, we report a case of secondary TTP following a severe infection.
基金supported by Qingdao Natural Science Foundation(No. 23-2-1-224-zyyd-jch)。
摘要Although the concentration of fine particulate matter(PM2.5)is reducing continuously,the proportion of secondary organic aerosols(SOA)in PM2.5 and the O3 levels are increasing.This is causing severe complex atmospheric pollution in North China.It is essential to identify and quantify the driving factors of SOA and O3,including the various pollution sources and meteorological factors.PM2.5 and volatile organic compounds(VOCs)samples were collected simultaneously in three cities in Shandong Province during different pollution scenarios from 2021 to 2023.Then,the carbonaceous aerosol and 99 VOC species were analyzed.Random forest(RF)combined with positive matrix factorization and an observation-based model(OBM)were used to quantify the key drivers of SOA and O3.Aromatic hydrocarbons were the main contributors to secondary organic aerosol potential(74.3%-89.9%),whereas alkenes contributed the most to the ozone formation potential(27.0%-62.3%).The RF modeling identified temperature and NOx as the dominant drivers of ozone formation.These accounted for 47.8%and 17.4%,respectively.Temperature showed a positive correlation with O3 because an increase in temperature can promote ozone formation.NOx had a significant negative correlation with O3,which was consistent with the conclusions from the sensitivity analysis of the OBM.The dominant contributors to SOA were vehicle emissions,solvent use,and industrial emissions.These accounted for 43.9%,18.2%,and 10.5%,respectively.An evident positive correlation existed between these emission sources and SOA.
基金financially supported by the National Key R&D Program of China(No.2024YFC3909501)Hebei Natural Science Foundation(No.E2024209158)+4 种基金Central Guidance Local Science and Technology Development Fund Project of Hebei Province(No.236Z1102G)S&T Program of Hebei(No.25363801D)Tangshan Municipal Project of Science and Technology(No.22130228H)Key Program of North China University of Science and Technology(No.ZD-ST-202312)Graduate Student Innovation Foundation of North China University of Science and Technology(No.2026B07).
摘要Titanium is widely regarded as a strategically important metal due to its outstanding properties and broad applications in metallurgy,aerospace,and energy sectors.However,with the gradual depletion of primary titanium ores,concerns over long-term supply security are becoming increasingly prominent.At present,less than 20%of titanium-bearing secondary resources are effectively utilized,while the majority are either stockpiled or discarded,resulting in both significant resource loss and environmental challenges.A comprehensive review of six representative titanium-bearing secondary resources,which were either derived from titanium production processes or contain relatively high levels of titanium,was conducted.These resources included titanium-bearing blast furnace slag,titanium-extracted tailings,ferrotitanium slag,titanium gypsum,spent selective catalytic reduction catalysts,and red mud.The chemical and mineralogical characteristics,utilization pathways,and underlying reaction mechanisms were systematically summarized.Particular attention was given to recent advances in extraction technologies for titanium recovery from these materials.From a practical standpoint,classifying and recycling these resources according to their intrinsic physicochemical properties could enable more targeted and efficient recovery strategies.Meanwhile,the development of low-carbon or carbon-neutral extraction technologies,together with environmentally benign leaching processes,remains highly desirable.Additionally,the integration of intelligent management systems for monitoring energy consumption,environmental impact,and economic performance will play a crucial role in advancing the sustainable utilization of titanium-bearing resources.
基金supported by the National Natural Science Foundation of China(Nos.52374148,52204163,and 52121003)the Fundamental Research Funds for the Central Universities(Nos.2025JCCXNY02 and 2023YQTD02)the Open Fund of State Key Laboratory of Water Resource Protection and Utilization in Coal Mining(No.GJNY-23-37-06).
摘要Accurate in-situ identification of coal and gangue is critical for intelligent mining,particularly in longwall top coal caving(LTCC)mining,where it enables precise control of the gangue mixed ratio and enhances resource recovery.This study introduces a Secondary Intervention strategy to augment the conventional“liquid intervention+infrared detection”approach.Results demonstrate that Secondary Intervention can consistently enhance the thermal contrast between coal and gangue,and the average accuracy of infrared image recognition for coal and gangue increased from 79.14%after the First Intervention to 93.75%after the Secondary Intervention,representing an improvement of 14.61%.Furthermore,the average contact angle difference between coal and gangue expanded from 16.64°after the First Intervention to 33.80°after the Secondary Intervention,an increase of 17.16°.Meanwhile,the area difference between coal and gangue increased by 4.94 times.Moreover,based on comprehensive analysis of the temperature difference,accuracy of morphological identification,as well as the contact angle and area of droplets,the eco-friendly compound surfactant(EFCS)of Soapnut Saponin(SS)+CTAB with a concentration of0.06 wt%demonstrated optimal performance.These findings advance liquid intervention techniques for infrared-based recognition and support the development of greener,more intelligent coal production systems.
基金supported by the Xinyang Academy of Ecological Research Institute Open Foundation(2023XYMS03)the Project of Zhao Haipeng Studio+1 种基金Chief Science Popularization Expert of Henan Province(HNKP2026106)the National Natural Science Foundation of China(32271734)。
摘要Understanding public conservation willingness is crucial for mitigating the global decline in avian diversity.Secondary school students,as key future actors and stakeholders in biodiversity conservation,represent a critical demographic,but their conservation willingness toward avian species remains largely underexplored.To address this gap,we conducted a questionnaire survey in 64 secondary schools across eight riparian cities along the Yellow River in Henan Province,China.Using the Great Bustard(Otis tarda)—a national first-class protected species and local conservation flagship—as the focal species,we constructed piecewise structural equation models(SEMs)to identify the key factors influencing students'conservation willingness.The questionnaire results revealed that although nearly 90%of students supported the Great Bustard conservation,only about 30%understood both its protection class and habitat characteristics,and less than half had relevant nature experience or had participated in local forestry departments'science communication activities.The piecewise SEM results demonstrated that students'interest in birds,knowledge level of the Great Bustard,and participation in science communication activities all exerted direct and significant positive influences on their conservation willingness.In addition to its direct effect,science communication engagement also indirectly enhanced conservation willingness by strengthening interest and knowledge,while the effects of grade level and nature experience were exclusively indirect,operating through the same pathways.To improve the effective conservation of the Great Bustard,we recommend that secondary schools strengthen collaborations with universities and nature reserves to enrich students'nature experience,and that local forestry departments further expand the coverage and depth of science communication activities targeting adolescent groups.
基金supported by Guangxi Key Research and Development Program(No.GUIKE AB22035081).
摘要Implementing advanced nitrogen removal in wastewater treatment plants has emerged as a critical strategy to comply with tightening global nitrogen discharge mandates.To achieve advanced nitrogen removal under low-carbon treatment conditions,pyrite-based mixotrophic denitrification(PMD)demonstrates promising application prospects.However,existing research predominantly focuses on synthetic wastewater in laboratory settings,with insufficient attention to practical applications using complex real wastewater.This study investigated PMD treating actual secondary effluent(TN:16-25 mg/L)from a full-scale wastewater treatment plant under natural aerobic conditions.Through optimized pyrite particle size(1.2-2.4 mm)and carbon-to-nitrogen ratio(C/N=3:1),PMD achieved 90.8%TN removal efficiency with effluent TN<2 mg/L,meeting stringent discharge standards.Under optimized conditions,oxygen boosted S2-/Fe2+release from pyrite.The 1.2-2.4 mm particles created micro-aerobic and micro-anaerobic niches,which facilitated synergistic symbiosis between autotrophic and heterotrophic denitrifiers.This microbial collaboration endowed the system with enhanced denitrification performance and improved filtration characteristics.The dominant bacterial genera in optimal conditions were unclassified_f_Rhodocyclaceae(22.4%),unclassified_f_Comamonadaceae(16.3%),and Thauera(5.9%),while nirK-type denitrifying bacteria dominated the denitrification in this system.This research offers valuable recommendations for developing an energy-efficient and low-carbon advanced nitrogen removal process in wastewater treatment facilities.
基金supported by the National Natural Science Foundation of China(Nos.22125303,92361302,92061203,22103082,22273101,22288201,and 21327901)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0970100)+4 种基金the National Key Research and Development Program of China(No.2021YFA1400501)the Innovation Program for Quantum Science and Technology(No.2021ZD0303304)Dalian Institute of Chemical Physics(No.DICP I202437)Chinese Academy of Sciences(No.GJJSTD20220001)the International Partnership Program of CAS(No.121421KYSB20170012)。
摘要Elucidating the interplay between different volatile organic compounds(VOCs)is crucial for understanding the formation mechanisms of secondary organic aerosols(SOA).This study systematically investigated the interactions between the bicyclic monoterpeneα-pinene and the monocyclic monoterpene limonene under NO2photooxidation and dark ozonolysis conditions.The results show that under the NO2photooxidation conditions,the increase of[limonene]0 enhances particle mass concentrations,number concentrations,and particle size;the increase of[α-pinene]0 results in the increase of particle mass and number concentrations without the increase of particle size.Under the dark ozonolysis conditions,particle mass and number concentrations increase with the increase of[α-pinene]0 and[limonene]0;the effect of increasing[α-pinene]0 on SOA mass concentration is significantly smaller than that of increasing[limonene]0,which may be attributed to the shift to a smaller particle size with the increase of[α-pinene]0.As the[limonene]0/[mixed VOCs]0 ratio increases from 0%to 100%,the SOA yield increases from 54.6%to 65.2%under the NO2photooxidation conditions and from 19.8%to 26.2%under the O3conditions.Using threshold photoionization mass spectrometry based on a vacuum ultraviolet free electron laser,a series of new products were detected at molecular weights of 364,366,380,386,411,413,and414,which could be assigned to the cross-dimers,such as organic peroxides,ester dimers,and organic nitrates.Our study underscores the critical role of monocylic monoterpene limonene in the SOA formation and advances our understanding of the SOA formation in the atmosphere.
基金supported by the World Health Organization Global Youth Tobacco Survey(WPDHP1206671)the Global Health Capacity Building and Tobacco Control Project:Tobacco Epidemic Monitoring and Comprehensive Tobacco Control Intervention。
摘要Adolescent smoking constitutes a critical public health challenge as early initiation increases the risk of premature mortality and smoking-related chronic diseases due to longer exposure and higher cumulative tobacco use[1].Adolescents are especially prone to developing persistent smoking habits,with many adult smokers having started before the age of 18.In China,16.7%of secondary school students have tried smoking and 4.7%are current smokers,highlighting the critical need for targeted tobacco control interventions among the youth.
基金Beijing Municipal Science and Technology Commission-funded Project:a Multicenter,Randomized Controlled Clinical Trial of“Lao Shi Zhen”Acupuncture for the Treatment of Postprandial Distress Syndrome(No.Z161100000516007)。
摘要OBJECTIVE:To assess the impact of body mass index(BMI)on the effectiveness of acupuncture in treating postprandial distress syndrome(PDS).METHODS:Data from 278 patients enrolled in a prior multicenter,randomized,sham-controlled trial were analyzed in this secondary study.Patients were classified into three groups according to baseline BMI:low,normal,and high.The primary outcome was the response rate after 4 weeks of treatment.The χ2 test was used to examine the effect of BMI on acupuncture efficacy.After multiple imputation for missing data,logistic regression analysis was performed to evaluate this association.A sensitivity analysis was conducted by combining the low and normal BMI groups.In addition,BMI was analyzed as a continuous variable using logistic regression to explore its relationship with treatment efficacy in the acupuncture group.RESULTS:The χ2 test revealed a statistically significant difference,with the acupuncture group demonstrating a markedly higher response rate than the sham group(82.91%vs 51.79%,χ2=25.34,P<0.001).In both the normal and high BMI categories,the response rate in the acupuncture group(82.91%)was higher than that in the sham acupuncture group(48.21%)(χ2=25.34,P<0.001).Following multiple imputation,logistic regression analysis demonstrated a significant overall association between BMI category and treatment response(P<0.001).Acupuncture showed superior efficacy compared with sham acupuncture[OR=1.97,95%CI(1.34,2.90),P<0.001].At week 4,response rates were 68.4%in the low BMI group,81.7%in the normal BMI group,and 96.3%in the high BMI group(χ2=6.303,P=0.043).A significant difference was observed only between the low and high BMI groups(χ2=6.717,P=0.010).Sensitivity analysis showed that the high BMI group achieved significantly better outcomes than the non-high BMI group in elimination rates at week 8 and week 12(χ2=4.571,P=0.033;χ2=4.589,P=0.032).Logistic regression analysis indicated that BMI was an independent predictor of response rate at week 4[OR=1.186,95%CI(1.010,1.394),P=0.038]and elimination rate at week 12[OR=1.126,95%CI(1.002,1.265),P=0.047],whereas no significant associations were observed at other follow-up points.CONCLUSION:This subgroup analysis indicated that acupuncture improved PDS symptoms across different BMI categories.Acupuncture was suggested as a viable therapeutic option for patients with PDS,particularly those with a higher BMI.
基金supported by the Key Research and Development Program of Xinjiang Uygur Autonomous Region(2024B02004)China Agriculture Research System of MOF and MARA(CARS-15-14)+1 种基金Fundamental Research Funds for the Central Universities(KYLH2023004,XUEKEN2023028)Collaborative Innovation Center for Modern Crop Production co-sponsored by Province and Ministry(CIC-MCP)。
摘要To determine how high temperature(HT)impairs cotton fiber elongation,greenhouse experiments compared two temperature regimes(CT,28℃HT,38℃)for 12 d.The findings indicated that compared with CT,the fiber elongation rate initially increased during HT(0-8 d),but subsequently decreased,resulting in a significant decrease in cotton fiber length at harvest.At 3 and 6 d under HT,cell turgor pressure increased;additionally,the auxin and ethylene content in fiber significantly increased,promoting cell wall loosening and increasing elongation rate through regulating xyloglucan endoglycosyltransferases/hydrolases and expansin.At 12 d under HT,cellulose and hemicellulose decomposition were inhibited in fiber,which hindered cell wall loosening and restricted fiber elongation.Meanwhile,the lipid and callose content in fiber was increased,and the enhanced abscisic acid and H2O2content promoted lignin synthesis by up-regulating the expression of WLIM1a gene.Both changes accelerated the initiation of secondary wall synthesis.Consequently,the transition stage that coincides with fiber elongation and secondary wall thickening was reduced by 0.3-0.5 d,leading to a decrease in fiber length.In summary,fiber length was reduced under HT,accompanied by restricted cell wall loosening and accelerated secondary wall synthesis.
基金Supported by the National Natural Science Foundation of China(No.82070964,No.82571210)Shaanxi Science Fund for Distinguished Young Scholars(No.2022JC-60)+3 种基金the International Scientific and Technological Cooperation Projects(No.2024GH-YBXM-20)the Open Research Funds of the State Key Laboratory of Ophthalmology(No.83000-32030002)Education Department of Shaanxi Provincial Government for Youth Innovation Team Research Program Project(No.23JP151,No.23JP150)General Projects of Hospital-level Research Topics in the Second Affiliated Hospital of Xi’an Medical University(No.22KY0111).
摘要AIM:To investigate the etiology and clinical characteristics of hospitalized secondary glaucoma(SG)patients in northwestern China.METHODS:A cross-sectional study was conducted involving SG patients hospitalized between July 2024 and January 2025.Clinical data were collected,including medical history,best-corrected visual acuity(BCVA),intraocular pressure(IOP),slit-lamp examination,gonioscopic findings,and fundus examination.Demographic characteristics,etiological factors,and treatment modalities were analyzed.RESULTS:A total of 67 patients(82 eyes)were enrolled,aged 7 to 90y.Males accounted for 54.0%(36/67),and 22.4%(15/67)of patients had bilateral involvement.The predominant etiologies of SG were neovascular glaucoma(NVG;25.4%),traumatic glaucoma(23.9%),uveitic glaucoma(20.9%),and lens-induced glaucoma(14.9%),collectively accounting for 85.1%of all cases.The peak age-specific incidence occurred in the 50-59 years age group(32.8%,22/67),while NVG was prevalent across the 40-79 years age range.IOP of the 82 affected eyes was stratified into five severity tiers:22-29 mm Hg(15 eyes,18.3%),30-39 mm Hg(14 eyes,17.1%),40-49 mm Hg(13 eyes,15.9%),50-59 mm Hg(20 eyes,24.4%),and≥60 mm Hg(20 eyes,24.4%).The overall mean IOP was 45.2±12.3 mm Hg,indicating a significant pathological elevation.Surgical intervention was required in 46.3%of cases,predominantly for NVG,lensinduced glaucoma,and traumatic glaucoma—conditions prone to rapid IOP elevation.The etiologies with the highest surgical intervention rates were malignant glaucoma,pigmentary glaucoma,lens-induced glaucoma,and NVG.In contrast,uveitic glaucoma cases were primarily managed with targeted anti-inflammatory therapy,which effectively controlled IOP in the early disease stages and potentially obviated the need for surgery.CONCLUSION:This study identifies NVG,traumatic glaucoma,uveitic glaucoma,and lens-induced glaucoma as the four leading etiologies of SG in Northwestern China.These findings emphasize the critical need for targeted prevention strategies and evidence-based health education programs among high-risk populations.Implementation of such initiatives will improve early detection,enable ophthalmologists to deliver timely therapeutic interventions,and ultimately reduce preventable vision loss in this region.
基金the financial support by the National Natural Science Foundation of China(Nos.52174269,52374293)the Science and Technology Innovation Program of Hunan Province,China(No.2022RC1123)。
摘要Synergistic sulfidation roasting of heavy metal gypsum residue and secondary zinc oxide fume was proposed by using the research idea of“waste to treat waste”.Thermodynamic studies indicated that the sulfidation of zinc oxide could be effectively enhanced by increasing the dosage of calcium sulfate and carbon powder in the range of 500-800℃.The synergistic sulfidation experiments of heavy metal gypsum residue with secondary zinc oxide showed that the sulfidation rate of zinc reached 90.39% and the grain size of ZnS increased from 5 to 10μm under the conditions of temperature 700℃,carbon powder 30%,Na2CO310%,mass ratio of gypsum residue to secondary zinc oxide 1.4꞉1,roasting time 2 h and cooling rate 1℃/min.Meanwhile,76.32%F,72.11%Cl and 93.41%As were removed.TG/DTG-DSC,3D FTIR spectra and SEM analysis showed that the conversion of CaSO4 to CaCO3 and the avoidance of CO2 and SO2 production were achieved under optimized conditions.This study achieves efficient sulfidation of zinc as well as growth of ZnS grains,laying the theoretical and technological foundation for subsequent recovery of ZnS by flotation.
基金supported by the State Key Laboratory of Cotton Bio-breeding and Integrated Utilization Open Fund(No.CB2024A22 and No.CB2024A19).
摘要Cotton fiber provides an exceptional model system for studying plant cell differentiation,elongation,and cell wall biogenesis.Recent advances in genomics,single-cell transcriptomics,genome editing,and multi-omics approaches have dramatically expanded our understanding of the molecular networks governing cotton fiber development.This review synthesizes current knowledge on the transcriptional,hormonal,epigenetic,and metabolic regulation of fiber initiation,elongation,and secondary cell wall(SCW)formation.We highlight the central roles of key transcription factors families—including MYB,HD-ZIP,bHLH,and NAC—in coordinating fiber cell fate determination and morphogenesis.We further discuss how phytohormones such as auxin,gibberellins,brassinosteroids,and strigolactones interact to regulate fiber elongation and SCW deposition.Emerging evidence also indicates that epigenetic mechanisms,including chromatin accessibility and RNA methylation,contribute to the fine-tuning of stage-specific gene expression.Furthermore,we explore how cytoskeletal dynamics and lipid metabolism contribute to polarized cell growth.Finally,we assess the potential of CRISPR-Cas9-mediated gene editing for cotton fiber improvement and propose future research directions aimed at bridging knowledge gaps between molecular mechanisms and agronomic traits.Despite these advances,several knowledge gaps remain,including the precise integration of hormonal hierarchies,the functional validation of predicted regulatory modules in polyploid cotton,and the translational feasibility of gene editing for fiber quality improvement under field conditions.
摘要In the implementation of the fundamental task of fostering virtue through education, mental health education delivered by secondary vocational class teachers serves as a core measure to expand the coverage of psychological services and build a full-scenario psychological education network. At present, the practical work faces multiple dilemmas: ambiguous power and responsibility boundaries for class teachers undertaking psychological education, low integration between mental health education and routine class management, inadequate targeted supply of tiered and categorized psychological services, and prominent deficiencies in supporting guarantee systems. In response, secondary vocational schools should clarify the power and responsibility list for class teachers’ psychological education and define the prohibited work scope, establish an integration mechanism linking mental health education with class management, construct a tiered and categorized psychological service supply system, and improve supporting modules including training and supervision, risk sharing, and performance incentives, so as to fully activate the psychological education capacity of class teachers.
基金supported by the Agritech National Research Center and received funding from the European Union Next-Generation EU[PIANO NAZIONALE DI RIPRESA E RESILIENZA(PNRR)—MISSIONE 4 COMPONENTE 2,INVESTIMENTO 1.4—D.D.103217/06/2022,CN00000022].
摘要Secondary metabolites play fundamental roles in apple,influencing the interaction with pollinators and frugivores for seed dispersal,contributing to fruit quality and promoting human health through their antioxidant property.Domestication and breeding have significantly re-shaped the apple metabolism,altering both aromatic profiles and nutritional properties.This study assessed the secondary metabolite variation in a comprehensive Malus spp.collection comprising 163 accessions belonging to 44 species.The profiling of phenolic and volatile organic compounds(VOCs),performed with Ultra-Performance Liquid Chromatography(UPLC)and Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry(PTR-ToF-MS)instruments respectively,in both skin and pulp tissues,uncovered distinct metabolic patterns between wild and domesticated apples.This investigation underlined the higher concentration of these metabolites in the skin tissue and revealed a clear metabolic divergence between the two groups of Malus accessions.Wild Malus spp.accessions resulted particularly rich in specific polyphenols characterized by antioxidant activity,including catechin and procyanidins.Conversely,apples of Malus domestica accessions exhibited a more abundant VOC profile,particularly represented by esters associated with fruity aroma,enhancing sensory appeal.These findings provide a foundation for leveraging wild germplasm in breeding programs,and the identification of accessions with high polyphenolic concentration and desirable aromatic profiles offers valuable opportunities to improve the aromatic and nutraceutical properties of apple.
基金Project supported by the National Science Foundation for Excellent Young Scholars(52222107)the Light of the Soviet Area-Innovation Leading Talent Program(GZSQZG202101007)+1 种基金the High-Level and High-Skilled Leading Talent Training Program of Jiangxi Provincethe research fund of Key Laboratory of Rare Earths of Chinese Academy of Sciences。
摘要Ni-Co-Mn-Ti alloys have become one of the most promising magnetic refrigeration materials due to their large magnetocaloric effect.However,magnetic hysteresis during magnetization and demagnetization cycles leads to considerable loss of hysteresis,thereby reducing the refrigeration capacity.Here,we report that the introduction of the rare-earth element Sc,leading to the formation of a secondary phase,significantly reduces the hysteresis loss in Ni-Co-Mn-Ti alloys.In the Ni37Co13Mn35Ti15-xScx(x=0,1.25,1.5,2)alloys,as the Sc content increases,the magnetic entropy change gradually decreases,while the refrigeration temperature range steadily broadens,and the magnetic hysteresis loss significantly reduces.When the Sc content reaches x=2,the magnetic hysteresis loss drops to 29.3 J/kg,representing an 70%reduction compared to the undoped sample(97.75 J/kg).Therefore,although the magnetic entropy change decreases,the substantial reduction in hysteresis loss and the expansion of the refrigeration temperature range lead to a reverse growth of the effective refrigerant capacity(RCeff).At the same time,the introduction of the second phase also leads to a significant improvement in mechanical properties.These findings suggest that introducing a secondary phase through Sc doping is an effective strategy for reducing hysteresis losses,making Ni-Co-Mn-Ti alloys a promising material system for magnetic refrigeration.
基金supported by the Chinese Research Academy of Envi-ronmental Sciences(No.2024YSKY-57)the National Key Research and Development Program of China(No.2017YFC0212501)Xinjiang Uygur Autonomous Region Environmental Monitoring Central Station(No.HYZB-2022-0320).
摘要Atmospheric oxidation capacity(AOC)refers to the oxidation capacity of atmospheric chemical processes for major pollutants.A comprehensive observation campaign was conducted on a typical PM2.5pollution event in Urumqi,Northwest China,from January 15 to February 15,2024.Four typical cases representing PM2.5levels from non-polluted to heavily polluted periods were selected to estimate AOC,OH reactivity,their relationship with secondary components,and the HOxbudget in PM2.5using the Framework for 0-D Atmospheric Modeling model.Aromatics and alkanes contributed 54%-79%and 18%-46%of secondary organic aerosols(SOA)formation,respectively.The sulfur oxidation ratio(SOR)and nitrogen oxidation ratio(NOR)increased with rising PM2.5levels.As AOC increased,SOR showed the same trend,while NOR and SOA decreased slightly,and ammonia oxidation ratio values remained almost unchanged.OH radicals were the primary oxidants during the daytime,whereas NO3played a dominant role at nighttime.CO(24%-51%),NO2(27%-34%),and alkenes(7%-12%)were the dominant contributors to OH reactivity.The HO2+NO reaction pathway contributes 67%-84%to the production of OH,while Others(including carbonyl compounds photolysis,the permutation reactions of RO2,etc.),RO2+NO and OH+CO reaction pathways were the main pathways for HO2 production.A comprehensive understanding of the interactions among AOC,SOA,and radical cycling is crucial for formulating effective air quality management strategies aimed at mitigating secondary pollution under diverse atmospheric conditions.
基金Project supported by the National Natural Science Foundation of China(No.32160108)the Science and Technology Special Fund of Hainan Province(No.ZDYF2024SHFZ116)+2 种基金the Specific Research Fund of the Innovation Center for Academicians of Hainan Province(No.YSPTZX202309)the Scientific Research Project of Hainan Higher Education Institutions(No.Hnky2022ZD-6)the Hainan Normal University National College Student Innovation Training Program(No.202411658006)。
摘要new heterocyclic dipeptide with a highly functionalized 1,2-oxazadecaline core,named trichodermamide H(1),and three known analogues,along with three known polyketides,were isolated from the fermentation extract of the mangrovederived fungus Penicillium janthinellum XLN32122.The structure of 1 was elucidated on the basis of extensive 1D and 2D NMR spectra data analysis,HR-ESI-MS,electronic circular dichroism(ECD)calculations.Trichodermamide B(3)exhibited better inhibitory effect on nitric oxide(NO)production in lipopolysaccharide(LPS)induced RAW 264.7 cells with an IC50value of(13.13±0.005)μmol/L than that of the positive control dexamethasone[IC50=(136.84±1.33)μmol/L].Compound 3 exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus(MRSA)with an IC50value of 12.5μg/mL,while the positive control vancomycin showed an IC50value of 1.563μg/mL.
基金supported by the National Key Research and Development Program of China(No.2023YFC3706203)the National Natural Science Foundation of China(No.42305100)Shandong Provincial Natural Science Foundation(No.ZR2023QD092).
摘要Biogenic volatile organic compounds(BVOCs),particularly terpenes,represent the dominant global source of secondary organic aerosols(SOA).However,the crucial investigation in terpene mixture under various nitrogen oxides(NOx)conditions needs to be further explored.To comprehensively understand the mixed SOA composition and its associated health effects,we simulated the mixed oxidation of α-pinene and isoprene in a smog chamber under various NOxconditions to investigate SOA formation and its related health effects.We found that increasing NOxlevels led to the formation of CHON compounds,suppressing functionalized products and oligomers.Results of the oxidative potential and total peroxides of SOA showed that mixed SOA had combined redox characteristics(isoprene SOA>mixed SOA>α-pinene SOA).The oxidative potential of isoprene SOA decreased as NOxincreased,whileα-pinene SOA was slightly affected.Results from iodometry combined with mass spectrometry indicated that hydrogen peroxides(ROOH)in highly oxygenated molecules played a crucial role in SOA health effects.NOxwas found to influence the production of ROOH by interfering with the RO2+HO2and RO2isomerization pathways.These results indicate that the reactive intermediate components in BVOC mixture under various NOxconditions are important factors influencing health effects of aerosol.
基金supported by Zhejiang Provincial Natural Science Foundation(LY22C090005)Science and Technology Initiative STI2030-Major Projects(2021ZD0203400)+1 种基金Scientific Research Starting Foundation of Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health)(OJQDSP2022007)National Key Research and Development Program of China(2022YFE0210100).
摘要Effective use of brain-computer interfaces(BCIs)requires the ability to suppress a planned action(volitional inhibition)for adaptable control in real-world scenarios,but their mechanisms are unclear.Here,we used fiber photometry to monitor external globus pallidus(GPe)and subthalamic nucleus(STN)neurons’activity in mice during a volitional stop-signal task(67%GO,33%NO-GO).GPe/STN neurons(receiving M2 projections)responded to auditory cues,feedback,and rewards in both trials.Importantly,chemogenetic activation of the M2-GPe pathway enhanced volitional inhibition by modulating auditory feedback response,yet inhibited GPe neurons’feedback response.Furthermore,time-locked optogenetic inhibition of M2-projecting GPe neurons at auditory feedback also enhanced volitional inhibition via prolonged GO trial response times.Collectively,these findings identified the M2-GPe pathway for auditory biofeedback to improve volitional control,offering novel avenues for the advancement of neural interfaces for biofeedback and enhancement of BCI efficacy.