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Existence and Uniqueness of the Dynamic Solution of a Series-Parallel Repairable System Consisting of Three-Unit with Multiple Vacations of a Repairman 认领 引用 被引量：2
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作者 Abdukerim Haji Tursunjan Keyim Bilikiz Yunus 《Journal of Applied Mathematics and Physics》 2016年第8期1585-1591,共7页
We investigate a series-parallel repairable system consisting of three-unit with multiple vacations of a repairman. By using C0-semigroup theory of linear operators in the functional analysis, we prove that the system... We investigate a series-parallel repairable system consisting of three-unit with multiple vacations of a repairman. By using C0-semigroup theory of linear operators in the functional analysis, we prove that the system is well-posed and has a unique positive dynamic solution. 展开更多
关键词 Series-Parallel Repairable System C_0-Semigroup Dynamic Solution
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Asymptotic Stability of a Series-Parallel Repairable System Consisting of Three-Unit with Multiple Vacations of a Repairman 认领 引用
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作者 Tursunjan Keyim Abdukerim Haji 《Journal of Applied Mathematics and Physics》 2017年第1期185-193,共9页
We study a series-parallel repairable system consisting of three units with multiple vacations of a repairman. We first show that all points on the imaginary axis except zero belong to the resolvent set of the operato... We study a series-parallel repairable system consisting of three units with multiple vacations of a repairman. We first show that all points on the imaginary axis except zero belong to the resolvent set of the operator and zero is an eigenvalue of the operator, and then we prove that the semigroup generated by the operator is irreducible. By combining these results with our previous result we deduce that the dynamic solution of the system converges strongly to its steady-state solution. Thus we obtain asymptotic stability of the dynamic solution of the system. 展开更多
关键词 Series-Parallel Repairable System C0-Semigroup Irreducibility Asymptotic Stability
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Bi-Objective Optimization of a Repairable M/M/(1+c)Queueing System with Two-Phase Service and Redundant Dependencies 认领 引用
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作者 XU Fan TIAN Ruiling SHAO Qi 《应用概率统计》 CSCD 北大核心 2026年第3期317-335,共19页
In this paper,we consider a repairable M/M/(1+c)queueing system with two-phase service and redundant dependencies,in which the second phase of service is provided by c identical servers,which randomly provide two type... In this paper,we consider a repairable M/M/(1+c)queueing system with two-phase service and redundant dependencies,in which the second phase of service is provided by c identical servers,which randomly provide two types of services to customers.The customers who enter the system are divided into Type 1 customers and Type 2 customers.If the waiting room of the second phase is not fully occupied,Type 2 customers can directly enter the second phase.In practice,there are various dependencies among the failure behaviors of the servers,which are called failure dependencies.We present a redundancy function to determine the failure rate of servers.We first derive the steady-state probabilities and performance measures of the system by quasi-birth-and-death(QBD)process theory and matrix-geometric solution method.Next,we provide numerical examples to illustrate the effects of four types of redundant dependencies on performance measures.Then,we construct a bi-objective optimal model and provide a scoring method that makes it possible to achieve an appropriate balance between the system cost and the service quality.Finally,the regression equation between the minimum cost and the waiting time is proposed,which is helpful to determine the minimum cost that meets the service quality. 展开更多
关键词 bi-objective optimization redundant dependency two-phase service QBD process repairable system
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Definition of critical skin defect and concepts of structural and functional repairs:Proposal and verification in a rat model 认领 引用 被引量：1
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作者 Cong Sun Weihong Guo +4 位作者 Fang Liang Rabia Javed Weijian Hou Xingdong Zhang Qiang Ao 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第1期168-182,共15页
Background:Rats are often used to prepare skin defect models.However,the skin defect sizes of the models prepared by researchers are different,and the lack of consensus on the critical-size defect makes it difficult t... Background:Rats are often used to prepare skin defect models.However,the skin defect sizes of the models prepared by researchers are different,and the lack of consensus on the critical-size defect makes it difficult to compare their research results.Methods:The time for wound closure was evaluated and recorded through gross observation.The regression equation between the healing time and the diameter of skin defect was established,which can be used to predict the healing time for a certain skin defect size in rats.Histochemical and immunohistochemical staining was used to observe the regeneration and reconstruction of skin appendages,and the functional skin repair was quantitatively scored.Results:The critical-size defect of rats was determined based on the maximum capacity of structural skin repair,and the functional skin repair was quantitatively scored based on the regeneration and reconstruction of skin appendages.The allowable range of critical-size skin defect of SD rats lies between 45 and 50 mm in diameter.The concept of structural repair and the category of functional repair of injured skin are put forward.The regression equation between the structural skin healing time and defect diameters is established.Conclusion:The allowable range of skin critical-size defect of SD rats lies between 45 and 50 mm in diameter.The regression equation between the structural skin healing time and defect diameters can be used to predict the healing time for a certain skin defect size in rats. 展开更多
关键词 critical defect functional repair quantitative evaluation skin defect structural repair
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Periosteal mitochondria DNA structures drive agingassociated poor skeletal repair 认领 引用 被引量：1
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作者 Yanlin Wu Chuyi Han +9 位作者 Xue Yang Yitian Wang Weidong Tian Quan Yuan Hui Wang Haisheng Wang Bei Yin Ling Ye Feifei Li Fanyuan Yu 《Bone Research》 SCIE CAS CSCD 2026年第3期819-831,共13页
Insufficient skeletal repair is the primary threat of health span and lifespan in elders with increasingly vast global burden;yet,to date,the knowledge of resolving this crisis remains limited.In this study,we address... Insufficient skeletal repair is the primary threat of health span and lifespan in elders with increasingly vast global burden;yet,to date,the knowledge of resolving this crisis remains limited.In this study,we addressed the specific mechanisms underlying agingassociated poor bone repair,which are driven by the mitochondrial DNA structures mitochondrial G-quadruplex(mtG4).We found that mtG4 is spatiotemporal-wisely accumulated within Pdgfra+periosteal mesenchymal stromal/stem cells(PPM)both in healthy and premature aging,which substantially increases cellular senescence and the degenerative alterations of PPM.By utilizing transgenic lineage tracking,PPM organoids formation,mitochondrial transgenic mutation,organoids transplantation,and serial cellular molecular investigations,we reveal that mtG4 in PPM restricts vital mitochondrial genes’transcription to cause mitochondrial dysfunction,which utterly leads to severe mitophagy and cell senescence.These senescent PPM demonstrates impaired stemness and disrupted fate determination,finally phenocopying aging-associated poor bone repair.This study decodes the mitochondrial genomic reasons for insufficient bone repair during aging,which offers insights for developing cell-type-and disease-specific senolytic therapies in the future. 展开更多
关键词 bone repair mitochondrial G quadruplex mitochondrial DNA periosteal mesenchymal stem cells mitochondrial dysfunction insufficient skeletal repair mitochondrial dna structures cellular senescence
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Magnetic resonance imaging tracing of superparamagnetic iron oxide nanoparticle-labeled mesenchymal stromal cells for repairing spinal cord injury 认领 引用 被引量：1
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作者 Xiaoli Mai Yuanyuan Xie +12 位作者 Zhichong Wu Junting Zou Jiacheng Du Yunpeng Shen Hao Liu Bo Chen Mengxia Zhu Jiong Shi Yang Chen Bing Zhang Zezhang Zhu Bin Wang Ning Gu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期2031-2039,共9页
Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in hu... Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury. 展开更多
关键词 acute spinal cord injury diffusion tensor imaging dynamic migration mesenchymal stromal cells neural function neuronal regeneration quantitative susceptibility mapping repairability ruicun superparamagnetic iron oxide nanoparticle
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An intra-string distributed and inter-string decentralized control method for hybrid series-parallel microgrids 认领 引用
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作者 Xiaochao Hou Jiatong He +3 位作者 Changgeng Li Zexiong Wei Kai Sun Yunwei Li 《iEnergy》 EI 2026年第1期30-42,共13页
The hybrid series-parallel microgrid attracts more attention by combining the advantages of both the series-stacked voltage and parallel-expanded capacity.Low-voltage distributed generations(DGs)are connected in serie... The hybrid series-parallel microgrid attracts more attention by combining the advantages of both the series-stacked voltage and parallel-expanded capacity.Low-voltage distributed generations(DGs)are connected in series to form the intra-string,and then multiple strings are interconnected in parallel.For the existing control strategies,both intra-string and inter-string depend on the centralized or distributed control with high communication reliance.It has limited scalability and redundancy under abnormal conditions.Alternatively,in this study,an intra-string distributed and inter-string decentralized control framework is proposed.Within the string,a few DGs close to the AC bus are the leaders to get the string power information and the rest DGs are the followers to acquire the synchronization information through the droop-based distributed consistency.Specifically,the output of the entire string has the active power−angular frequency(ω-P)droop characteristic,and the decentralized control among strings can be autonomously guaranteed.Moreover,the secondary control is designed to realize multi-mode objectives,including on/off-grid mode switching,grid-connected power interactive management,and off-grid voltage quality regulation.As a result,the proposed method has the ability of plug-and-play capabilities,single-point failure redundancy,and seamless mode-switching.Experimental results are provided to verify the effectiveness of the proposed practical solution. 展开更多
关键词 Hybrid series-parallel microgrid Distributed control Decentralized control Power inverter
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Auxin promotes cucumber resistance to high ambient temperature by enhancing photosystem and activating DNA repair pathways 认领 引用
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作者 Bingwei Yu Yujia Lin +9 位作者 Yuwei Gan Chenyu Yang Yonggui Liang Qiteng Qin Liping Chen Renjian Liu Hongbo Zhao Zhengkun Qiu Bihao Cao Shuangshuang Yan 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第7期1681-1696,共16页
Global warming poses a huge challenge for plants to withstand increasing ambient temperatures.Cucumber is a kind of worldwide vegetable crop which is very sensitive to high temperature(HT).The mechanism of auxin affec... Global warming poses a huge challenge for plants to withstand increasing ambient temperatures.Cucumber is a kind of worldwide vegetable crop which is very sensitive to high temperature(HT).The mechanism of auxin affecting plant resistance to high temperature is still unclear.This study showed the relationship between auxin and heat resistance of cucumber.Here,we found that exogenous auxin improved cucumber heat tolerance by promoting root activity and mitigating the accumulation of ROS at the cotyledon stage.Additionally,exogenous auxin delayed internode shortening and leaf senescence under HT at three true-leaf stage.Exogenous auxin maintains photosystem II(PS II)stability in the thermotolerant cucumber plants.Transcriptome results indicated that photosynthesis and DNA repair processes were activated by exogenous 2,4-dichlorophenoxyacetic acid(2,4-D).Moreover,glutathione metabolism and carotenoid biosynthesis process were involved in ROS scavenging after the 2,4-D treatment under HT.In addition,overexpression of auxin biosynthesis gene CsYUC10b elevated cucumber resistance to high temperatures and enhanced the photosystem activity and DNA repair ability.Thus,auxin promoted heat resistance in cucumber by enhancing PS II and activating DNA repair pathways. 展开更多
关键词 Cucumber Auxin Heat resistance Photosystem II DNA repair
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A nature-derived,strong adhesive hydrogel microsphere for wet tissue repair:Multifunctional and clinical potential 认领 引用
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作者 Liwen Zheng Jixian Feng +8 位作者 Yaxian Liu Jianming Zhang Yuheng Wang Xingrui Yan Ge Wang Lan Li Yuan Pang Hongmei Zhang Ximu Zhang 《Bioactive Materials》 SCIE CSCD 2026年第7期448-463,共16页
In dynamic and fluid-rich environments,achieving stable bioscaffold adhesion to tissue surfaces while facili-tating therapeutic delivery always presents significant challenges.Inspired by the nature adhesive mechanism... In dynamic and fluid-rich environments,achieving stable bioscaffold adhesion to tissue surfaces while facili-tating therapeutic delivery always presents significant challenges.Inspired by the nature adhesive mechanisms of skin section of Andrias davidianus(SSAD),we engineered SSAD@GelMA microspheres(SGM)as a novel multi-functional biomimetic platform,combining strong bioadhesion,cell/drug delivery capabilities,and extracellular matrix(ECM)remodeling.Preclinical evaluation in wound models demonstrated SGM exceptional adhesive strength,maintaining stable attachment even under continuous fluid shear stress.Unlike conventional hydrogel microspheres,the unique multifunctionality of SSAD enables SGM to serve dual roles as both an advanced biomimetic platform and an effective tissue-repairing agent for wet wound healing applications.Through effi-cient delivery of therapeutic agents or cells in wet environments and promotion of ECM remodeling,SGM significantly enhanced tissue repair across various in vivo wet tissue models,including bone tissue,cartilage tissue,soft tissue.These findings introduce a promising class of wet-adhesive microspheres with broad potential for adaptation to diverse fluid-rich tissue regeneration scenarios. 展开更多
关键词 Andrias davidianus Hydrogel microsphere Wet adhesion Wound repairing Bioplatform
Male germ cell-specific deletion of Eif5 causes the apoptosis of mouse progenitor spermatogonia by excessive endoplasmic reticulum stress and defective DNA repair 认领 引用
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作者 Hongwei Wei Yating Huang +11 位作者 Weiyong Wang Shuang Liu Huiyu Liu Hanyu Chu Yan-Li Sun Yan Du Wenqian Li Luchun Zhang Yashuang Weng Wenbo Zhang Meijia Zhang Zhijuan Wang 《Zoological Research》 SCIE CSCD 2026年第2期503-518,共16页
Idiopathic non-obstructive azoospermia(iNOA)is associated with reduced expression of multiple eukaryotic translation initiation factors(EIFs)in spermatogonia,including eukaryotic translation initiation factor 5(EIF5).... Idiopathic non-obstructive azoospermia(iNOA)is associated with reduced expression of multiple eukaryotic translation initiation factors(EIFs)in spermatogonia,including eukaryotic translation initiation factor 5(EIF5).The present study revealed that eIF5 mRNA and protein levels were markedly higher in male mouse(Mus musculus)germ cells than in Leydig or Sertoli cells.Thus,to define the role of eIF5 in spermatogenesis,Eif5 conditional knockout(cKO)mice were generated by crossing Eif5fl/fl mice with Stimulated by retinoic acid 8(Stra8)-Cre mice.Loss of Eif5 in male germ cells reduced both SRY-box transcription factor 3(SOX3)+progenitor spermatogonia and Kit proto-oncogene receptor tyrosine kinase(KIT)+differentiating spermatogonia,leading to severe meiotic failure and complete male infertility.Mechanistically,Eif5 deficiency impaired translation of genes involved in ubiquitination,autophagy,and DNA repair,which,in turn,triggered excessive endoplasmic reticulum(ER)stress and compromised DNA repair in SOX3+progenitor spermatogonia.These defects promoted DNA damage and subsequent apoptosis,resulting in progressive germ cell depletion and sterility.Collectively,these findings highlight the essential role of eIF5 in spermatogenesis and offer a potential therapeutic strategy for iNOA associated with reduced expression of EIF5 and other translation initiation factors. 展开更多
关键词 eIF5 Endoplasmic reticulum stress DNA repair Male infertility
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Assessment of VOC mitigation from equipment leaks in petroleum refining in Guangdong,China:Insights from a long-term leak detection and repair(LDAR)implementation 认领 引用
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作者 Xi-Bo Sun Cheng-Hao Liao +4 位作者 Zhi-Yang Liu Yong-Bo Zhang Xiao-Ming Liang Li-Min Chen Dai-Qi Ye 《Petroleum Science》 SCIE EI CAS CSCD 2026年第6期3698-3709,共12页
Fugitive volatile organic compound(VOC)emissions from equipment leaks in the petroleum refining industry threaten ambient air quality and human health.The impact of a long-term leak detection and repair(LDAR)on mitiga... Fugitive volatile organic compound(VOC)emissions from equipment leaks in the petroleum refining industry threaten ambient air quality and human health.The impact of a long-term leak detection and repair(LDAR)on mitigating these emissions has not been adequately elucidated.Herein,we explored the VOC emission characteristics and mitigation from a petroleum refinery in a long-term LDAR implementation,established emission factors at production unit-level and enterprise-level,and assessed the VOC mitigatio n,ozone formation potential(OFP)and seconda ry organic ae rosol formation potential(SOAP)from equipment leaks of petroleum refining in Guangdong,China.The results indicated that the long-term implementation of LDAR at the enterprise-level petroleum refining facility resulted in an approximately 40.5%reduction in overall VOC emissions.Kerosene hydrotreating unit(KHU),catalytic reforming unit(CRU),delayed coking unit(DCU),aromatics recovery complex(ARC),and hydrocracking unit(HCU)were the top five units for emission reduction,while valves and connectors were the top two sealing points.The implementation of LDAR across all petroleum refineries in Guangdong Province achieved annual VOC emission reductions ranging from 129.0 to 160.5 tons between 2018 and2022,with corresponding reductions in OFP and SOAP of approximately 68.2%.Alkenes/alkynes were the primary contributors to OFP,whereas aromatics dominated SOAP.Three recommendations were proposed for the optimization of future LDAR implementation policies:to emphasize the quality control and assurance of LDAR detection data;to establish a refined LDAR work plan that integrates production units and sealing points;and to conduct LDAR work on a regular and continuous basis. 展开更多
关键词 Petroleum refining Leak detection and repair VOC mitigation Emission factors Control policy
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Integrated implantable triboelectric charge collector for nerve repair 认领 引用
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作者 Chenglong Cai Ting Wang +4 位作者 Yixin Zhang Conghao Lin Zhangqi Feng Yan Cai Nongyue He 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期601-606,共6页
The employment of low-frequency electrical stimulation therapy has been shown to elicit a pronounced depolarization of neurons,thereby initiating the regenerative signaling cascades within neural cells,which is favora... The employment of low-frequency electrical stimulation therapy has been shown to elicit a pronounced depolarization of neurons,thereby initiating the regenerative signaling cascades within neural cells,which is favorable for the regeneration of neural cells.In this study,we designed the flexible triboelectric nanogenerator device(TENG) to treat injury of peripheral nerve,which is combined with mesoporous silica(H-SiO2),high dielectric performance of polydimethylsiloxane(PDMS),and connected to biocompatible and conductive polycaprolactone(PCL) conduit materials for limited power generation to neurobioelectric response adaptation.By adjusting the content of H-SiO2 and the amount of PDMS monomers,the electrical performance of the device is optimized.Through the charge collection effect of silica molecular sieve,the endogenous neural electric field in nerve injury was stabilized,ensuring the consistency of the electrical stimulation level that is crucial for maintaining resting membrane potential.In vitro experiments clearly demonstrated that electrical stimulation derived from the triboelectric nanogenerator significantly promotes cell proliferation.Further animal experiments confirmed that electrical stimulation can effectively treat sciatic nerve injury and accelerate axonal regeneration.Based on experimental outcomes,we have developed an implantable sciatic nerve system that can stably generate effective electrical pulses in response to rat movement through charge collection.This system regulates the electric field around the injured sciatic nerve,maintains the electric field threshold required for rapid nerve tissue repair,and accelerates the recovery of nerve function. 展开更多
关键词 Triboelectric nanogenerator Nerve repair Electrical stimulation Implantable flexible devices Mesoporous material
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Direct repair of spent LiFePO4 via a closed-loop deep eutectic solvent process 认领 引用
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作者 Yuelin Kong Shuaipeng Hao +8 位作者 Yaqi Liao Yudi Shao Le Hu Wei Liu Yuanguang Xia Wen Yin Jingwei Xiang Yunhui Huang Lixia Yuan 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第6期224-233,I0007,共10页
The LiFePO4 batteries are expected to face a significant wave of retirement in the coming years.This necessitates the establishment of a comprehensive and environmentally friendly recycling system for spent LiFePO_... The LiFePO4 batteries are expected to face a significant wave of retirement in the coming years.This necessitates the establishment of a comprehensive and environmentally friendly recycling system for spent LiFePO4 batteries.The traditional hydrometallurgical and pyrometallurgical methods involve high costs and serious pollution.This work provides a more efficient and environmentally benign alternative by repairing spent LiFePO4 through a citric acid-LiCl deep eutectic solvent(DES).The citric acid and LiCl form a molten state through hydrogen bonding at lower temperatures,enabling the ambient-pressure repair.The LiCl acts as a Li source to replace the lost Li.The citric acid donates electrons to reduce Fe3+to Fe2+,reducing electrostatic repulsion to facilitate Fe to return to its original lattice site,thereby eliminating Fe-Li anti-site defects and promoting the insertion of Li+into the lattice.Remarkably,this method eliminates the strict requirement for Li/Fe molar ratio control,making it applicable to spent LiFePO4 batteries with varying degradation levels.The regenerated LiFePO4 shows great electrochemical performance with a discharge capacity of 158.3 mA h g-1at 0.5C,with a capacity retention of 82.8%after600 cycles.Notably,the DES demonstrates recyclability and stable regeneration efficiency,while its eco-friendly nature further enhances the economic viability and industrial potential of this process. 展开更多
关键词 Spent LiFePO4batteries Deep eutectic solvent Fe-Li anti-site defects Ambient-pressure repair
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Advancements in design,surface modification,and spinal applications of biomedical metallic materials for bone repair 认领 引用
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作者 Shiqiang Song Lizhu Tang +3 位作者 Longjian Huang Yuanli Luo Huiqing Yang Chengliang Yang 《Metals Advances》 SCIE EI CAS CSCD 2026年第4期49-65,共17页
Bone defect repair imposes stringent requirements on biomaterials,including mechanical compatibility,biocompatibility,osteoinduction/osteoconduction,and biodegradability.Biomedicalmetallic materials serve as core solu... Bone defect repair imposes stringent requirements on biomaterials,including mechanical compatibility,biocompatibility,osteoinduction/osteoconduction,and biodegradability.Biomedicalmetallic materials serve as core solutions for bone reconstruction due to their exceptional mechanical strength,particularly in high-loadbearing regions such as the spine.To address metallic surface bioinertness,various surface modification technologies are widely employed to significantly enhance osseointegration,antibacterial efficacy,and corrosion resistance through microano-structuring and bioactive coatings.3D printing enables customized fabrication of porous metallic implants,optimizing mechanical compatibility and imaging compatibility.In spinal applications,metallic materials are extensively utilized in internal fixation systems,interbody cages,artificial discs/vertebrae,correction systems,and tumor prostheses.Their design and modification directly impact fusion success rates,anti-subsidence capability,and long-term stability.Despite significant progress,challenges remain in degradation rate matching,long-term biosafety,multifunctional synergy,and stability in complex physiological environments.Future efforts should focus on smart materials,precision surface engineering,AI-assisted personalized design,and long-term clinical evaluation to advance metallic bone-repair materials toward superior performance. 展开更多
关键词 Biomedical metallic materials Bone repair Surface modification Spinal implants 3D printing Osseointegration
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An Ultrasmall Strontium-Loaded Polydopamine Nanoformulation for Near-Infrared-Enhanced Periodontitis Therapy via Photodynamic Gas-Promoted Antibacterial and Bone Repair 认领 引用
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作者 Hao Liang Yu Liang +12 位作者 Rubiao Qiu Kunpeng Duan Jiaxiao Li Yan Liu Xiaowen Li Li Wang Lingling Liang Mingyang Jiang Chenxi Wang Guojiang Chen Ming Gao Xiaojie Li Tao Qin 《Rare Metals》 SCIE EI CAS CSCD 2026年第3期484-499,共16页
Periodontitis is a chronic infectious oral disease triggered by periodontopathogenic bacteria,resulting in the progressive inflammation and destruction of the tissues surrounding teeth.To achieve reprogramming of the ... Periodontitis is a chronic infectious oral disease triggered by periodontopathogenic bacteria,resulting in the progressive inflammation and destruction of the tissues surrounding teeth.To achieve reprogramming of the infectious microenvironment for periodontitis therapy,a nanoformulation was proposed by loading polydopamine(PDA)with ultrasmall strontium through in situ reduction and arginine by Michael addition,defined as PA.Combined with near infrared(NIR)irradiation,it could efficiently scavenge reactive oxygen species(ROS),and downregulate inflammatory factors expression through inhibiting NF-κB pathway.In addition,it also confirmed the effective bacteria killing in NIR stimulated PA by photothermal effects and nitric oxide(NO)generation.Significantly,PA+NIR was also verified to promote alveolar bone tissue repair through strontium ions(Sr2+)and NO induced angiogenesis,together with Sr2+mediated osteogenesis.The administration strategy was finally verified to alleviate the oxidative stress derived inflammation,suppress bacterial growth and biofilm formation,as well as promote bone regeneration with high efficacy and biosafety in the periodontitis rat models.All the above findings contributed to the NIR enhanced synergistic treatment of periodontitis,and it may serve as a promising strategy for the treatment of other inflammation related diseases. 展开更多
关键词 bone promoting repair metal loaded polydopamine NF-κB pathway inhibition periodontitis photodynamic gas therapy
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Extracellular Vesicles:A New Dimension in Nerve Injury Repair 认领 引用
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作者 Miaomei Yu Yang Yu +5 位作者 Jiayi Zhou Jiang Wei Liuchang Song Jun Zhang Lu Zheng Fei Ding 《Engineering》 SCIE EI CSCD 2026年第7期66-80,共15页
Peripheral and central nerve injuries present significant challenges in clinical practice due to the paucity of effective therapeutic options. Extracellular vesicles (EVs), lipid membrane-encapsulated nanoparticles re... Peripheral and central nerve injuries present significant challenges in clinical practice due to the paucity of effective therapeutic options. Extracellular vesicles (EVs), lipid membrane-encapsulated nanoparticles released from most cell types, are enriched in bioactive molecules capable of mediating intercellular communication. Recently, EVs have shown potential for applications in regenerative medicine, notably as alternatives to cell therapy. A therapeutic paradigm shift is emerging towards the EV-based treatment of nerve injury. Accumulating evidence indicates that EVs promote nerve regeneration and functional recovery, primarily by modulating neural cell function, immune-inflammatory responses, and angiogenesis. Various strategies have been developed to incorporate EVs into nerve grafts or to utilize them as diagnostic and therapeutic vehicles. This review aimed to provide a systematic survey of the available literature on the latest progress in EV-based treatments for peripheral nerve, spinal cord, and brain injuries. Additionally, prospects of EV-based nerve injury repair are discussed in terms of deep mechanistic understanding, technological innovations, and interdisciplinary convergence. 展开更多
关键词 Extracellular vesicles Peripheral nerve injury Sciatic nerve injury Brain injury Nerve injury repair Nerve grafts
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Robotic or laparoscopic inguinal hernia repair?A narrative review of the current literature 认领 引用
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作者 Alberto G.Barranquero Loreto Martín Ferrero +4 位作者 Laia Codina Corrons Yolanda Maestre Gonzalez Cristina Gas Ruiz Alfredo Escartín Arias Rafael Villalobos Mori 《Laparoscopic, Endoscopic and Robotic Surgery》 2026年第1期8-15,共8页
Robotic inguinal hernia repair remains in the early stages of implementation,and its potential advantages over the laparoscopic approach are still a matter of debate.This narrative review aims to summarize the finding... Robotic inguinal hernia repair remains in the early stages of implementation,and its potential advantages over the laparoscopic approach are still a matter of debate.This narrative review aims to summarize the findingsof major systematic reviews and randomized controlled trials and explore variables not adequately addressed in those studies.The literature review indicates that robotic inguinal hernia repair is associated with longer operative times but has improved ergonomics compared with laparoscopy.It is a safe procedure that results in a reduced inflammatory response,similar complication rates,and no significantdifference in acute postoperative pain.Although it involves higher direct costs,its cost-effectiveness remains unclear owing to a lack of analysis including indirect costs.Ongoing controversy continues regarding long-term benefits.The most recent systematic review pointed towards lower recurrence rates with robotic surgery,although randomized controlled trials have not validated this finding.Data on chronic pain are currently insufficientto draw firmconclusions.Further studies are needed to assess its use in complex cases and the role of novel techniques. 展开更多
关键词 Inguinal hernia repair Robotic surgery Laparoscopic surgery Surgical outcomes Minimally invasive techniques
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Photobiomodulation repairs the blood-spinal cord barrier in a mouse model of spinal cord injury 认领 引用
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作者 Yangguang Ma Yi Liu +6 位作者 Dongsheng Pan Jiawei Zhang Zhuowen Liang Yi Wang Xueyu Hu Zhe Wang Tan Ding 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2475-2484,共10页
The blood-spinal cord barrier is crucial for preserving homeostasis of the central nervous system.After spinal cord injury,autophagic flux within endothelial cells is disrupted,compromising the integrity of the blood-... The blood-spinal cord barrier is crucial for preserving homeostasis of the central nervous system.After spinal cord injury,autophagic flux within endothelial cells is disrupted,compromising the integrity of the blood-spinal cord barrier.This disruption facilitates extensive infiltration of inflammatory cells,resulting in exacerbated neuroinflammatory responses,neuronal death,and impaired neuronal regeneration.Previous research has demonstrated that photobiomodulation promotes the regeneration of damaged nerves following spinal cord injury by inhibiting the recruitment of inflammatory cells to the injured site and restoring neuronal mitochondrial function.However,the precise mechanisms by which photobiomodulation regulates neuroinflammation remain incompletely elucidated.In this study,we established a mouse model of spinal cord injury and assessed the effects of photobiomodulation treatment.Photobiomodulation effectively cleared damaged mitochondria from endothelial cells in mice,promoting recovery of hindlimb motor function.Using microvascular endothelial bEnd.3 cells subjected to oxygen-glucose deprivation,we found that the effects of photobiomodulation were mediated through activation of the PINK1/Parkin pathway.Additionally,photobiomodulation reduced mitochondrial oxidative stress levels and increased the expression of tight junction proteins within the blood-spinal cord barrier.Our findings suggest that photobiomodulation activates mitochondrial autophagy in endothelial cells through the PINK1/Parkin pathway,thereby promoting repair of the blood-spinal cord barrier following spinal cord injury. 展开更多
关键词 autophagy blood-spinal cord barrier endothelial cell mitochondria neuroinflammatory photobiomodulation PTEN-induced kinase 1 repair spinal cord injury tight junction
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Cognitive Erasure-Coded Data Update and Repair for Mitigating I/O Overhead 认领 引用
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作者 Bing Wei Ming Zhong +2 位作者 Qian Chen Yi Wu Yubin Li 《Computers, Materials & Continua》 SCIE EI 2026年第2期1706-1725,共20页
In erasure-coded storage systems,updating data requires parity maintenance,which often leads to significant I/O amplification due to“write-after-read”operations.Furthermore,scattered parity placement increases disk ... In erasure-coded storage systems,updating data requires parity maintenance,which often leads to significant I/O amplification due to“write-after-read”operations.Furthermore,scattered parity placement increases disk seek overhead during repair,resulting in degraded system performance.To address these challenges,this paper proposes a Cognitive Update and Repair Method(CURM)that leverages machine learning to classify files into writeonly,read-only,and read-write categories,enabling tailored update and repair strategies.For write-only and read-write files,CURM employs a data-differencemechanism combined with fine-grained I/O scheduling to minimize redundant read operations and mitigate I/O amplification.For read-write files,CURM further reserves adjacent disk space near parity blocks,supporting parallel reads and reducing disk seek overhead during repair.We implement CURM in a prototype system,Cognitive Update and Repair File System(CURFS),and conduct extensive experiments using realworld Network File System(NFS)and Microsoft Research(MSR)workloads on a 25-node cluster.Experimental results demonstrate that CURMimproves data update throughput by up to 82.52%,reduces recovery time by up to 47.47%,and decreases long-term storage overhead by more than 15% compared to state-of-the-art methods including Full Logging(FL),ParityLogging(PL),ParityLoggingwithReservedspace(PLR),andPARIX.These results validate the effectiveness of CURM in enhancing both update and repair performance,providing a scalable and efficient solution for large-scale erasure-coded storage systems. 展开更多
关键词 Erasure coding machine learning cognitive update and repair I/O amplification mitigation seekefficient recovery
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Essential genetic mutations impair DNA damage repair and modulate tumor immune microenvironment in ccRCC 认领 引用
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作者 Hongchao He Xian-De Liu Eric Jonasch 《MedScience》 SCIE CAS CSCD 2026年第2期231-246,共16页
Targeting DNA repair defects has shown therapeutic benefits in solid tumors with genetic mutations that disrupt DNA damage repair(DDR)pathways.Clear cell renal cell carcinoma(ccRCC)demonstrates an intermediate level o... Targeting DNA repair defects has shown therapeutic benefits in solid tumors with genetic mutations that disrupt DNA damage repair(DDR)pathways.Clear cell renal cell carcinoma(ccRCC)demonstrates an intermediate level of genomic instability,while it rarely carries mutations in these genes.Instead,it is characterized by the loss of chromosome 3p,the von Hippel‑Lindau(VHL)tumor suppressor gene inactivation,and secondary mutations in Polybromo‑1(PBRM1),SET domain‑containing 2(SETD2),and BRCA‑associated protein 1(BAP1).Here,we summarize and discuss how these essential mutations impair the DDR,activate the cytosolic DNA sensing pathway,alter the tumor immune microenvironment,and offer promising therapeutic targets. 展开更多
关键词 DNA damage repair defect tumor immune microenvironment clear cell renal cell carcinoma
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