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Prolonged consumption of white beer increases levels of short-chain fatty acids and Prevotellaceae bacteria in mice 认领 引用
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作者 Zhaoxi Liu Yongheng Rong +5 位作者 Shuxia Huang Hua Yin Lushan Wang Shumin Hu Junhong Yu Min Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期67-79,共13页
Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as... Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as a comprehensive intervention on human health and immune status.This study used a 14-day continuous drinking intervention consisting of 5 beers,namely white beer,India pale ale(IPA),Pilsner,non-alcoholic beer,and premium lager beer.Surprisingly,our findings indicate that consuming white beer has little impact on the gut microbiota and physiological condition of mice,whereas consuming other types of beer leads to an increase in Lactobacillus and a decrease in Lachnospiraceae.In addition,we devised an extended feeding experiment to investigate the comparative safety and health benefits of consuming white beer.The research showed that when mice drank excessive quantities of white beer over 42 days,the intestines of the mice had more Prevotellaceae and the Firmicutes to Bacteroidetes ratio(F/B ratio)had a decline from 1.29 to 0.38.The levels of acetic acid,propionic acid,and isobutyric acid increased from 1.0,0.27,and 0.015 mg/g to 1.28,0.38,and 0.037 mg/g,respectively(P<0.05).There were no significant changes observed in the levels of most measured cytokines in the colon tissue of mice that consumed beer,however,there was an increase in the concentration of the inflammatory factor tumor nesrosis factor-α(TNF-α)from 135.86 pg/mL in the control group to 189.78 pg/mL in the white beer group(P<0.01).These results give us real-world proof that we can use to study how different beers affect the host’s health and satisfaction in future research. 展开更多
关键词 Gut microbiota Beer Cytokine Short-chain fatty acids White beer Prevotellaceae
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Gut microbiota-mediated short-chain fatty acids contribute to the protective effects of Xiaoxuming decoction(小续命汤)against lipopolysaccharide-induced acute lung injury 认领 引用
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作者 XIANG Yijin YANG Zhigang +2 位作者 GONG Shaomin LI Xiangting CAI Min 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第2期285-293,共9页
OBJECTIVE:To investigate the mechanisms underlying the protective effects of Xiaoxuming decoction(小续命汤,XXMD)against lipopolysaccharide(LPS)-induced acute lung injury(ALI).METHODS:LPS was used to construct an ALI m... OBJECTIVE:To investigate the mechanisms underlying the protective effects of Xiaoxuming decoction(小续命汤,XXMD)against lipopolysaccharide(LPS)-induced acute lung injury(ALI).METHODS:LPS was used to construct an ALI model in mice and human pulmonary alveolar epithelial cells(HPAEpiCs).Acetate and acetate-producing bacteria,including Blautia hydrotrophica,Bacteroides thetaiotaomicron,Akkermansia muciniphila,and Bacteroides vulgatus,were detected after XXMD treatment.Zonula occludens-1(ZO-1),occludin,phosphorylated nuclear factor-kappa B p65(p-NF-κBp65),and NF-κBp65 levels were measured by Western blotting,and an enzyme-linked immunosorbent assay was performed to detect tumor necrosis factor-alpha(TNF-α),interleukin-1 beta(IL-1β),and IL-6 secretion.Transepithelial electrical resistance,fluorescein isothiocyanate-dextran,and cell counting kit-8 assays were used to detect the cell's monolayer integrity,permeability,and viability.RESULTS:XXMD alleviated the LPS-induced downregulation of acetate and acetate-producing bacteria in feces.Furthermore,XXMD suppressed the LPS-induced downregulation of ZO-1 and occludin expression in lung tissues,LPS-induced upregulation of TNF-α,IL-1β,and IL-6 in bronchoalveolar lavage fluid,and p-NF-κBp65 levels in lung tissues.Acetate had similar effects in LPS-induced mice.Meanwhile,the seven-day survival probability was improved by XXMD or acetate treatment.Furthermore,acetate could alleviate LPS-mediated cell viability,inflammation,and permeability in HPAEpiCs,while acetate-induced effects could be abrogated by GLPG0974,a short-chain fatty acid(SCFA)receptor G-protein coupled receptor 43 antagonist.CONCLUSION:XXMD's therapeutic effect may be related to gut microbiota-mediated SCFAs,which alleviated LPS-induced ALI. 展开更多
关键词 acute lung injury short-chain fatty acids permeability Xiaoxuming decoction
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Antibiotic-sensitive gut symbiont Turicibacter sanguinis alleviates constipation by enhancing short-chain fatty acids and tryptophan metabolism 认领 引用
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作者 Ruocen Tian Xinyue Hu +4 位作者 Leilei Yu Fengwei Tian Jianxin Zhao Qixiao Zhai Wei Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3104-3115,共12页
Turicibacter sanguinis is a prominent genus within the mammalian gut microbiota and is associated with various metabolic and gastrointestinal disorders,including overweight,obesity,irritable bowel syndrome(IBS)and con... Turicibacter sanguinis is a prominent genus within the mammalian gut microbiota and is associated with various metabolic and gastrointestinal disorders,including overweight,obesity,irritable bowel syndrome(IBS)and constipation.However,the specific roles of T.sanguinis in host physiology remain unclear.In this study,antibiotic intervention experiments in mice revealed that T.sanguinis abundance was significantly reduced by intervention with sisomicin sulfate,ribostamycin sulfate,and cefadroxil,providing a T.sanguinis-depleted model for further investigations.By analyzing 6040 gut metagenomes,we observed an enrichment of T.sanguinis in IBS patients,while its abundance was significantly decreased in individuals with constipation.Next,using a T.sanguinis-depleted mouse model,we further validated the functional role of T.sanguinis in alleviating loperamide-induced constipation.Analysis of short-chain fatty acid(SCFA)and metabolomics revealed that T.sanguinis supplementation increased the levels of butyrate and isobutyrate in the colon and enhanced tryptophan metabolism,particularly elevating 5-hydroxytryptamine(5-HT)levels in intestinal tissue.Together,our findings identify T.sanguinis as a microbial mediator in antibiotic-associated constipation and offer new insights into microbiota-targeted therapies for functional gastrointestinal disorders. 展开更多
关键词 Gut microbiota Turicibacter sanguinis Constipation Antibiotic Short-chain fatty acid 5-Hydroxytryptamine
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Microbial fermentation of blue honeysuckle(Lonicera caerulea L.)polyphenol promotes insulin secretion and intervenes in obesity by promoting short-chain fatty acids production 认领 引用
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作者 Fangyi Pei Xinbo Cao +4 位作者 Yanxin Ren Liangyang Mao Yueyi Liu Jingping Ge Wenxiang Ping 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第4期1449-1468,共20页
During obesity treatment,clinicians have been burdened by the ever-increasing number of patients and the side effects of drug treatment.Finding new plant-derived active ingredients as an intervention for obesity has b... During obesity treatment,clinicians have been burdened by the ever-increasing number of patients and the side effects of drug treatment.Finding new plant-derived active ingredients as an intervention for obesity has become a research focus.In this study,Plackett-Burman and Central Composite Design experiments,plant-wide target metabolomics technology,simulated human colon fermentation test,and cell experiment in vitro were successively used to investigate the effects of fermented and unfermented polyphenols(FP and UP,respectively)of blue honeysuckle on obesity.After the optimization of the response surface method,polyphenol content((1878.08±14.53)mg/100 g)increased by 2.63 times after Lactobacillus rhamnosus 6224 and Saccharomyces cerevisiae W5 mixed fermentation.There were 23 significantly different metabolites were observed in FP and UP.Of them,7 different metabolites were significantly and positively correlated with short-chain fatty acids(SCFAs),whereas negatively correlated with lipopolysaccharides(LPS).The contents of these 7 metabolites were significantly increased in FP.Furthermore,the effects of FP and UP on the SCFA biosynthesis pathway were different.Cell experiments revealed that polyphenols can significantly promote the secretion of gastrointestinal endogenous hormones and insulin and inhibit interleukin-6 levels.Linear regression analysis revealed SCFAs had a positive regulatory effect on glycolipid metabolism,whereas LPS had a negative effect.Overall,these crucial findings provide an economical and simple method for obtaining blue honeysuckle polyphenols and laying a theoretical foundation for its application in the therapeutic intervention against obesity. 展开更多
关键词 Obesity Blue honeysuckle Polyphenol Short-chain fatty acids In vitro fecal fermentation
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Associations Between Gut Microbiota,Short-Chain Fatty Acids,and High-Salt Diet-Induced Hypertension in Rats 认领 引用
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作者 Lin Li Sen-jie Zhong +2 位作者 Hao Liang Si-yuan Hu Zhi-xi Hu 《Current Medical Science》 SCIE CAS CSCD 2025年第4期715-724,共10页
Numerous studies have established a link between hypertension(HTN)and a high-salt diet(HSD).However,the precise mechanisms are still being investigated,with increasing evidence suggesting that HSD can alter the gut mi... Numerous studies have established a link between hypertension(HTN)and a high-salt diet(HSD).However,the precise mechanisms are still being investigated,with increasing evidence suggesting that HSD can alter the gut microbiome balance,influence the production of microbiome metabolites and potentially lead to high blood pressure,presenting a promising avenue for targeting specific microbiota in HTN treatment.Short-chain fatty acids(SCFAs)are produced by gut bacteria and are associated with blood pressure regulation.Thus,the relationships among HSD,SCFAs,and blood pressure could provide valuable information on the pathophysiology of HTN.This study aimed to assess the impact of HSD on HTN by investigating its influence on the gut microbiota composition and SCFA levels in a rat model of HTN. 展开更多
关键词 Hypertension Gut microbiota High-salt diet Short-chain fatty acids
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Prophylactic treatment of Lacticaseibacillus paracasei K56 ameliorates asthma by regulating short-chain fatty acid production and Treg differentiation 认领 引用
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作者 Jiaqi Cui Yanfei Hong +8 位作者 Wei-Hsien Liu Wen Zhao Xinmei Nan Xuekai Shang Yalan Li Haotian Feng Qiuyue Jiang Wei-Lian Hung Guiying Peng 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第2期581-593,共13页
Many studies have shown that the development of allergic asthma is associated with intestinal microbiota dysbiosis.Based on the gut-lung axis theory,probiotic intervention may be a potential strategy for respiratory d... Many studies have shown that the development of allergic asthma is associated with intestinal microbiota dysbiosis.Based on the gut-lung axis theory,probiotic intervention may be a potential strategy for respiratory diseases.Lacticaseibacillus paracasei K56 was reported to regulate gut microbiota in mice.However,its effect on allergic asthma has not been reported.In this study,we investigated the effect of the K56 on ovalbumininduced asthma and its possible mechanisms.Our results showed that K56 reduced asthma symptoms and inflammatory cell infiltration in the lung of asthmatic mice.And K56 regulated the differentiation of helper T cells in the lung and intestine.Results from 16S r RNA gene sequencing showed that K56 prophylaxis significantly elevated the richness of Akkermansia and Burkholderia.Meanwhile,K56 abrogated the decrease in the levels of short-chain fatty acids(SCFAs)in the feces.In addition,a rebound in the m RNA expression of the SCFA receptors was observed after K56 prophylaxis.Notably,the regulatory T cell(Treg)frequencies and the FFAR3 levels were positively correlated.These results suggest that K56 could attenuate asthma,possibly by modulating the intestinal microbiota and regulating Treg differentiation through SCFA metabolized.Our study showed that K56 may be used as a probiotic to prevent pulmonary inflammation and dysbiosis of the intestinal microbiota in allergic asthma. 展开更多
关键词 Lacticaseibacillus paracasei K56 Allergic asthma Gut-lung axis helper T cells Short-chain fatty acids
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Roles of short-chain fatty acids in metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis 认领 引用
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作者 Chun-Ye Zhang Shuai Liu +1 位作者 Yu-Xiang Sui Ming Yang 《World Journal of Hepatology》 2025年第11期82-97,共16页
Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most common chronic liver disease,affecting more than 30%of adults and 7%-14%of youths globally.MASLD and its advanced form of metabolic dysfunctio... Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most common chronic liver disease,affecting more than 30%of adults and 7%-14%of youths globally.MASLD and its advanced form of metabolic dysfunctionassociated steatohepatitis(MASH)can progress to liver cirrhosis and hepatocellular carcinoma.Despite its growing burden,effective therapies for MASLD and MASH remain limited.Accumulating evidence indicates that short-chain fatty acids(SCFAs)modulate the activation of hepatic innate and adaptive immune cells,influencing liver inflammation and fibrosis.Moreover,SCFAs modulate liver lipid and glucose metabolism and insulin sensitivity,affecting MASLD progression.This review summarizes the cellular and molecular mechanisms through which SCFAs impact liver inflammation,fibrosis,and energy metabolism.Several key molecular signaling pathways are discussed.Clinical trials aiming to modulate SCFA production through different treatments are reviewed.Collectively,emerging evidence supports that targeting SCFA-mediated function represents a promising therapeutic strategy for MASLD and MASH. 展开更多
关键词 Short-chain fatty acids Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis Inflammation Immune response Metabolism
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Vinasses valorization into short-chain fatty acids:microbiome robustness against process variations 认领 引用
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作者 Silvia Greses Mercedes Llamas +1 位作者 Aboudi Kaoutar Cristina González-Fernández 《Bioresources and Bioprocessing》 SCIE EI CSCD 2025年第1期409-419,共11页
The valorization of vinasses into short-chain fatty acids(SCFAs)via anaerobic fermentation(AF)is an emerging approach that remains under research.Given the diverse microbial metabolisms simultaneously occurring in AF,... The valorization of vinasses into short-chain fatty acids(SCFAs)via anaerobic fermentation(AF)is an emerging approach that remains under research.Given the diverse microbial metabolisms simultaneously occurring in AF,the control of operational parameters is essential to avoid process destabilization.To unravel their effect,the novelty of this investigation relied on the evaluation of the robustness of AF process against operational perturbation deliberately set(i.e.hydraulic retention time(HRT)and temperature increase).Regardless the applied perturbation,similar yields(0.5-0.6 g COD-SCFAs/g VSin)were attained.However,the selected perturbations exerted an effect on microbiome development.Whereas the temperature increase mediated a 49.70%microbiome dissimilarity,only a 21.91%dissimilarity was caused by the HRT increase.Microbial analysis revealed Clostridiales,Prevotella and Megasphaera as key bacteria in vinasses degradation.The similar bioconversion obtained despite the different microbiomes developed after each perturbation suggested a functional redundancy highlighting the AF robustness.These findings evidenced AF as a feasible biotechnology to further valorize vinasse into SCFAs,demonstrating the process stability against common perturbations that might be encountered at industrial scale. 展开更多
关键词 Short-chain fatty acids Crop residue Vinasses Anaerobic fermentation Process perturbations Microbiome robustness
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Protective effect of marine animal hydrolysis-peptides on adjuvant-induced arthritis in mice by gut microbiota and short-chain fatty acids 认领 引用
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作者 Zhen Zhang Shasha Tang +8 位作者 Ziyan Wang Jiaojiao Han Jun Zhou Chenyang Lu Bin Liu Xiaoling Sun Rongxian Yu Rixin Wang Xiurong Su 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第1期361-370,共10页
Marine fauna provides a plentiful repository of peptides and bioactive proteins.Peptides and proteins isolated from marine animals have been studied and applied in the development of food supplements,drugs,and cosmece... Marine fauna provides a plentiful repository of peptides and bioactive proteins.Peptides and proteins isolated from marine animals have been studied and applied in the development of food supplements,drugs,and cosmeceutical products because of their special bioactivities,such as anti-inflammatory and antioxidant effects.This study focused on exploring the alleviating effects of five major marine animal-derived peptides(Apostichopus japonicus,Acaudina leucoprocta,Melanogrammus aeglefinus,Phascolosoma esculenta and Rhopilema esculentum)on adjuvant-induced arthritis(AIA).The treatment with five marine animals-derived peptides downregulated the expression levels of pro-inflammatory cytokines of interleukin(IL)-1β,IL-17 and tumor necrosis factor(TNF)-α in the bones of the mice with AIA and alleviated the rough surface of bone tissues significantly.A.japonicus-treatment ameliorates inflammation by restoring nuclear factor-κB pathway in AIA mice.High-throughput sequencing of the gut microbiota based on 16S rRNA sequencing revealed that A.japonicus peptide-treated AIA mice showed alterations and imbalance of intestinal flora and an increased abundance of Lactobacillus and Clostridium.Furthermore,metabolomic analysis showed that the level of short-chain fatty acids(SCFAs)in the feces was enhanced to different degrees in mice treated with five major marine animal-derived peptides.Taken together,we propose that major marine animal-derived peptides can alleviate arthritis by improving the imbalance in the gut flora and increasing SCFAs production to varying degrees. 展开更多
关键词 Marine animals-derived peptides Adjuvant-induced arthritis Gut flora Short-chain fatty acid
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Anti-inflammatory properties of the short-chain fatty acids acetate and propionate:A study with relevance to inflammatory bowel disease 认领 引用 被引量：97
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作者 Sofia Tedelind Fredrik Westberg +1 位作者 Martin Kjerrulf Alexander Vidal 《World Journal of Gastroenterology》 SCIE CAS 2007年第20期2826-2832,共7页
AIM： To compare the anti-inflammatory properties of butyrate with two other SCFAs, namely acetate and propionate, which have less well-documented effects on inflammation. METHODS： The effect of SCFAs on cytokine rel... AIM： To compare the anti-inflammatory properties of butyrate with two other SCFAs, namely acetate and propionate, which have less well-documented effects on inflammation. METHODS： The effect of SCFAs on cytokine release from human neutrophils was studied with EHSA. SCFA- dependent modulation of NF-κB reporter activity was assessed in the human colon adenocarcinoma cell line, Colo320DM. Finally, the effect of SCFAs on gene expression and cytokine release, measured with RT-PCR and ELISA, respectively, was studied in mouse colon organ cultures established from colitic mice. RESULTS： Acetate, propionate and butyrate at 30 mmol/L decreased LPS-stimulated TNFα release from neutrophils, without affecting IL-8 protein release. All SCFAs dose dependently inhibited NF-κB reporter activity in Colo320DM cells. Propionate dose-dependently suppressed IL-6 mRNA and protein release from colon organ cultures and comparative studies revealed that propionate and butyrate at 30 mmol/L caused a strong inhibition of immune-related gene expression, whereas acetate was less effective. A similar inhibition was achieved with the proteasome inhibitor MG-132, but not the p38 MAPK inhibitor SB203580. All SCFAs decreased IL-6 protein release from organ cultures. CONCLUSION： In the present study propionate and butyrate were equipotent, whereas acetate was less effective, at suppressing NF-κB reporter activity, immune-related gene expression and cytokine release in vitro. Our findings suggest that propionate and acetate, in addition to butyrate, could be useful in the treatment of inflammatory disorders, including IBD. 展开更多
关键词 Neutrophils Epithelial cells Colitis Infla- mmation Short-chain fatty acids Acetate Propionate Butyrate NF-KB Cytokines
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Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition 认领 引用 被引量：34
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作者 Stéphane M Schneider Fernand Girard-Pipau +5 位作者 Jérome Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal 《World Journal of Gastroenterology》 SCIE CAS 2005年第39期6165-6169,共5页
AIM:To assess the effects of Sb on fecal flora and shortchain fatty acids(SCFA)in patients on long-term TEN.METHODS:Ten patients(3 females,7 males,59±5.5 years),on TEN for a median of 13 mo(1-125),and 15 healthy ... AIM:To assess the effects of Sb on fecal flora and shortchain fatty acids(SCFA)in patients on long-term TEN.METHODS:Ten patients(3 females,7 males,59±5.5 years),on TEN for a median of 13 mo(1-125),and 15 healthy volunteers(4 females,11 males,32±2.0 years)received Sb(0.5 g bid PO)for 6 d.Two stool samples were taken before,on the last 2 d and 9-10 d after treatment,for SCFA measurement and for culture and bacterial identification.Values(mean4-SE)were compared using sign tests and ANOVA.RESULTS:Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg)than in controls(19.2±3.9,P=0.02).Treatment with Sb increased total fecal SCFA levels in patients(150.2+27.2 vs 107.5±18.2 mmol/kg,P=0.02)but not in controls(129.0±28.6 vs 113.0±15.2 mmol/kg,NS).At the end of treatment with Sb,patients had higher fecal butyrate(16.0±4.4 vs 10.1[2.9]mmol/kg,P=0.004).Total SCFAs remained high 9 d after treatment was discontinued.Before the treatment,the anaerobe to aerobe ratio was lower in patients compared to controls(2.4±2.3 vs 69.8±1.8,P=0.003).There were no significant changes in the fecal flora of TEN patients.CONCLUSION:Sb-induced increase of fecal SCFA concentrations(especially butyrate)may explain the preventive effects of this yeast on TEN-induced diarrhea. 展开更多
关键词 Enteral nutrition Diarrhea Saccharomyces boulardii Short-chain fatty acids Intestinal microbiota
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Short-chain fatty acids can improve lipid and glucose metabolism independently of the pig gut microbiota 认领 引用 被引量：24
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作者 Hua Zhou Bing Yu +4 位作者 Jing Sun Zuohua Liu Hong Chen Liangpeng Ge Daiwen Chen 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2021年第4期1414-1427,共14页
Background:Previous studies have shown that exogenous short-chain fatty acids(SCFAs)introduction attenuated the body fat deposition in conventional mice and pigs.However,limited studies have evaluated the effects of e... Background:Previous studies have shown that exogenous short-chain fatty acids(SCFAs)introduction attenuated the body fat deposition in conventional mice and pigs.However,limited studies have evaluated the effects of exogenously introduced SCFAs on the lipid and glucose metabolism independently of the gut microbiota.This study was to investigate the effects of exogenous introduction of SCFAs on the lipid and glucose metabolism in a germ-free(GF)pig model.Methods:Twelve hysterectomy-derived newborn pigs were reared in six sterile isolators.All pigs were hand-fed with sterile milk powder for 21 d,then the sterile feed was introduced to pigs for another 21 d.In the second 21-d period,six pigs were orally administrated with 25 mL/kg sterile saline per day and considered as the GF group,while the other six pigs were orally administrated with 25 mL/kg SCFAs mixture(acetic,propionic,and butyric acids,45,15,and 11 mmol/L,respectively)per day and regarded as FA group.Results:Orally administrated with SCFAs tended to increase the adiponectin concentration in serum,enhance the CPT-1 activity in longissimus dorsi,and upregulate the ANGPTL4 mRNA expression level in colon(P<0.10).Meanwhile,the mRNA abundances of ACC,FAS,and SREBP-1C in liver and CD36 in longissimus dorsi of the FA group were decreased(P<0.05)compared with those in the GF group.Besides,the mRNA expression of PGC-1αin liver and LPL in longissimus dorsi tended to(P<0.10)upregulate and downregulate respectively in the FA group.Moreover,oral administration of SCFAs tended to increase the protein level of GPR43(P<0.10)and decrease the protein level of ACC(P<0.10)in liver.Also,oral administration of SCFAs upregulated the p-AMPK/AMPK ratio and the mRNA expressions of GLUT-2 and GYS2 in liver(P<0.05).In addition,the metabolic pathway associated with the biosynthesis of unsaturated fatty acids was most significantly promoted(P<0.05)by oral administration of SCFAs.Conclusions:Exogenous introduction of SCFAs might attenuate the fat deposition and to some extent improve the glucose control in the pig model,which occurred independently of the gut microbiota. 展开更多
关键词 Germ-free Glucose metabolism Lipid metabolism Pig model Short-chain fatty acids
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Validation of a HRGC–ECNI/LRMS method to monitor short-chain chlorinated paraffins in human plasma 认领 引用 被引量：9
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作者 Jiazhi Xu Weijing Guo +5 位作者 Linhuan Wei Yuan Gao Haijun Zhang Yichi Zhang Ming Sun Jiping Chen 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2019年第1期289-295,共7页
Short-chain chlorinated paraffins(SCCPs) are produced in high volume and have the high potential to pose a threat to human health. However, little information is available for SCCP contamination in human blood/plasma/... Short-chain chlorinated paraffins(SCCPs) are produced in high volume and have the high potential to pose a threat to human health. However, little information is available for SCCP contamination in human blood/plasma/serum, mainly due to the difficulty of sample preparation and quantitative analysis. A method using high resolution gas chromatography coupled with electron capture negative ionization low resolution mass spectrometry(HRGC–ECNI/LRMS) was developed and validated to measure SCCPs in human plasma. The pretreatment process included protein denaturation and lipid elimination, liquid–liquid extraction with a mixture of n-hexane/dichloromethane(1:1, V/V), and cleanup on a multilayer silica column. The blank controls, including procedural blank, vacuum blood collection tube blank, and instrumental blank, were the most pivotal points for the reliable analysis of SCCPs. The average value of procedural blanks was 9.0 ng/g; and the method detection limit(MDL), calculated as the sum of the average procedural blank value and 3 times of the standard deviation of the procedural blanks, was 12.6 ng/g plasma. The validated method was applied to measure the concentrations of the total SCCPs(∑ SCCPs) in50 plasma samples from a general population. The measured plasma concentrations of ∑SCCPs ranged from <MDL to 203 ng/g wet weight(ww), with an average value of 32.0 ng/g ww.The relative abundance profiles of SCCPs in plasma samples were dominated by C10- and C11-CP congener groups centered on Cl6–7. The developed method can be used for the comprehensive and large-scale investigation of SCCP levels in human plasma. 展开更多
关键词 Short-chain chlorinated paraffins sample preparation Quantitative analysis Human plasma
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The role of gut microbiota and its metabolites short-chain fatty acids in food allergy 认领 引用 被引量：16
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作者 Chen Chen Chenglong Liu +1 位作者 Ke Zhang Wentong Xue 《Food Science and Human Wellness》 SCIE CAS CSCD 2023年第3期702-710,共9页
Emerging evidence indicated that the increase in food allergy(FA)over the past few decades was associated with the abnormal compositional and metabolic changes of gut microbiota.Gut microbiota played a vital role in m... Emerging evidence indicated that the increase in food allergy(FA)over the past few decades was associated with the abnormal compositional and metabolic changes of gut microbiota.Gut microbiota played a vital role in maintaining the homeostasis of the immune system and the dysbiosis of gut microbiota promoted the occurrence of FA.Recent research suggested that short-chain fatty acids(SCFAs),the main metabolites derived from gut microbiota,contributed to FA protection.Herein,we provided a comprehensive review on the relationship between gut microbiota and FA.The multifaceted mechanisms underlymg beneficial effects of gut microbiota composition/metabolites on the regulation of diverse cellular pathways in intestinal epithelial cells,dendritic cells,innate lymphoid cells,T cells,B cells and mast cells in the immune system were discussed systematically.These findings emphasized the positive function of gut microbiota in FA and provided novel ideas for the treatment or prevention of FA in the future. 展开更多
关键词 Gut microbiota Composition Short-chain fatty acids Immune system Food allergy
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Prebiotic oligosaccharides change the concentrations of short-chain fatty acids and the microbial population of mouse bowel 认领 引用 被引量：12
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作者 Xiao-dong PAN Fen-qin CHEN +2 位作者 Tian-xing WU Hong-gang TANG Zhan-yu ZHAO 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS 2009年第4期258-263,共6页
The purpose of this study was to clarify effects of selected oligosaccharides on concentrations of cecal short-chain fatty acids （SCFAs）, total large bowel wet weight and wall weight, and cecal microbiota levels in ... The purpose of this study was to clarify effects of selected oligosaccharides on concentrations of cecal short-chain fatty acids （SCFAs）, total large bowel wet weight and wall weight, and cecal microbiota levels in mice. Mice were respectively given gavage of selected fructooligosaccharides （FOS）, galactooligosaccharides （GOS）, mannanoligosaccharides （MOS）, and ehitooligosaccharides （COS） [1000 mg/（kg body weightd）]. Control group was given physiological saline solution. After 14 d treatment, SCFAs and lactate in mice cecum were significantly increased （P〈0.05） by intake of oligosaccharides, especially FOS and GOS. Thus, providing these oligosaccharides as ingredients in nutritional formulas may benefit the gastrointestinal tract. 展开更多
关键词 Oligosaccharides Short-chain fatty acids （SCFAs） Bifidobacteria Lactobacilli Mouse
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The short-chain perfluorinated compounds PFBS,PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation 认领 引用 被引量：19
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作者 Shuyu Liu Renjun Yang +1 位作者 Nuoya Yin Francesco Faiola 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2020年第2期187-199,共13页
Per-and polyfluorinated alkyl substances(PFASs) are commonly used in industrial processes and daily life products.Because they are persistent, they accumulate in the environment, wildlife and humans.Although many stud... Per-and polyfluorinated alkyl substances(PFASs) are commonly used in industrial processes and daily life products.Because they are persistent, they accumulate in the environment, wildlife and humans.Although many studies have focused on two of the most representative PFASs, PFOS and PFOA, the potential toxicity of short-chain PFASs has not yet been given sufficient attention.We used a battery of assays to evaluate the toxicity of several four-carbon and six-carbon perfluorinated sulfonates and carboxyl acids(PFBS,PFHxS, PFBA and PFHxA), with a human mesenchymal stem cell(hMSC) system.Our results demonstrate significant cyto-and potential developmental toxicity for all the compounds analyzed, with shared but also distinct mechanisms of toxicity.Moreover, the effects of PFBS and PFHxS were stronger than those of PFBA and PFHxA, but occurred at higher doses compared to PFOS or PFOA. 展开更多
关键词 Short-chain perfluorinated compounds Human mesenchymal stem cells(hMSCs) Adipogenesis/osteogenesis Developmental toxicity PFBS/PFBA/PFHxS/PFHxA
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Supplementing the early diet of broilers with soy protein concentrate can improve intestinal development and enhance short-chain fatty acid-producing microbes and short-chain fatty acids,especially butyric acid 认领 引用 被引量：10
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作者 Qianyun Zhang Shan Zhang +2 位作者 Shu Wu Marianne Hjollund Madsen Shourong Shi 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2023年第1期278-294,共17页
Background:Research on nutrition in early-life commonly focuses on the maturation of the intestine because the intestinal system is crucial for ensuring continued growth.To explore the importance of early nutrition re... Background:Research on nutrition in early-life commonly focuses on the maturation of the intestine because the intestinal system is crucial for ensuring continued growth.To explore the importance of early nutrition regulation in animals,soy protein concentrate(SPC)was added to the early diet of broilers to investigate its effects on amino acid digestibility,intestinal development,especially intestinal microorganisms,and broiler metabolites.A total of 192 oneday-old Arbor Acres(AA)male broilers were randomly assigned to two experimental treatments with 8 replicates of 12 birds.The control group was fed a basal diet(control),and the treatment group was fed a basal diet supplemented with 12%SPC(SPC12)during the first 10 d(starter phase).From d 11 to 21(grower phase)and d 22 to 42(finisher phase),a basal diet was fed to both treatment groups.Results:SPC reduced the pH value and acid-binding capacity of the starter diet(P<0.05,d 10);SPC in the early diet enhanced the gizzard weight(P<0.05,d 10 and d 42)and the ileum weight(P<0.05,d 10)and decreased the weight and length of the jejunum(P<0.05,d 10)and the relative length of the duodenum and jejunum(P<0.05,d 10).At the same time,SPC enhanced villus height(P<0.05,d 10)and muscle thickness in the jejunum and ileum(P<0.05,d 10)and increased the number of goblet cells in the duodenum(P<0.05,d 10).Meanwhile,SPC increased the Chao1 index and the ACE index(P<0.05,d 10)and altered the composition of caecal microflora at d 10.SPC also increased the relative abundance of Alistipes,Anaerotruncus,Erysipelatoclostridium,Intestinimonas and Flavonifractor bacteria(P<0.05,d 10).At the same time,the concentrations of caecal butyric acid and total short-chain fatty acids(SCFAs)were also increased in the SPC12 group(P<0.05,d 10).Conclusions:In summary,the results showed that supplementing the starter diet of broilers with SPC has a significant effect on the early development of the intestine and the microflora. 展开更多
关键词 Broiler Caecal microbiota Intestinal development Short-chain fatty acids Soy protein concentrate
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Role of short-chain fatty acids in host physiology 认领 引用 被引量：12
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作者 Mingyue Liu Yubo Lu +7 位作者 Guoyu Xue Le Han Hanbing Jia Zi Wang Jia Zhang Peng Liu Chaojuan Yang Yingjie Zhou 《Animal Models and Experimental Medicine》 CAS CSCD 2024年第5期641-652,共12页
Short-chain fatty acids(SCFAs)are major metabolites produced by the gut microbiota through the fermentation of dietary fiber,and they have garnered significant attention due to their close association with host health... Short-chain fatty acids(SCFAs)are major metabolites produced by the gut microbiota through the fermentation of dietary fiber,and they have garnered significant attention due to their close association with host health.As important mediators between the gut microbiota and the host,SCFAs serve as energy substrates for intestinal epithelial cells and maintain homeostasis in host immune and energy metabolism by influencing host epigenetics,activating G protein-coupled receptors,and inhibiting pathogenic microbial infections.This review provides a comprehensive summary of SCFAs synthesis and metabolism and offering an overview of the latest research progress on their roles in protecting gut health,enhancing energy metabolism,mitigating diseases such as cancer,obesity,and diabetes,modulating the gut-brain axis and gut-l ung axis,and promoting bone health. 展开更多
关键词 gut microbiota host i nteraction relationship short-chain fatty acids
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Gut-brain axis:Focus on gut metabolites short-chain fatty acids 认领 引用 被引量：13
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作者 Cen Guo Ya-Jing Huo +2 位作者 Yu Li Yan Han Da Zhou 《World Journal of Clinical Cases》 SCIE 2022年第6期1754-1763,共10页
Emerging evidence supports that the gut microbiome,reconsidered as a new organ in the human body,can not only affect the local gut,but also communicate with the brain via multiple pathways related to neuroendocrine,im... Emerging evidence supports that the gut microbiome,reconsidered as a new organ in the human body,can not only affect the local gut,but also communicate with the brain via multiple pathways related to neuroendocrine,immune,and neural pathways,thereby proposing the new concept of the microbiome-gut-brain(MGB)axis.Recently,the role of short-chain fatty acids(SCFAs),which are the main anaerobic fermented metabolites of the gut microbiota in the MGB axis,has garnered significant attention.SCFAs are involved in a broad range of central neurological diseases,including neurodegenerative diseases,cerebral vascular diseases,epilepsy,neuroimmune inflammatory diseases,and mood disorders.However,the underlying mechanism of SCFA-related distant organ crosstalk is yet to be elucidated.Herein,we summarize current knowledge regarding interactions between SCFAs and the MGB axis,as well as their protective effects against central neurological diseases. 展开更多
关键词 Gut-brain axis Short-chain fatty acids Neurological disease Microbiome-gutbrain
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Milk fat globule membrane supplementation protects againstβ-lactoglobul-ininduced food allergy in mice via upregulation of regulatory T cells and enhancement of intestinal barrier in a microbiota-derived short-chain fatty acids manner 认领 引用 被引量：11
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作者 Han Gong Tiange Li +3 位作者 Dong Liang Jingxin Gao Xiaohan Liu Xueying Mao 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第1期124-136,共13页
Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects ... Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice model.MFGM was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body weight.Results demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula occludens-1.Furthermore,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A expressions.The increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain extent.In summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of GPRs.These findings suggest that MFGM may be useful as a promising functional ingredient against CMA. 展开更多
关键词 Cow’s milk allergy Milk fat globule membrane Gut microbiota Short-chain fatty acid G protein-coupled receptor Regulatory T cell
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