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Lean-Six Sigma模型在医师资格实践技能考试考务管理中的思考 认领 引用 被引量：1
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作者 高远 杨艳 +2 位作者 元梦如 周强 曹伟 《继续医学教育》 2025年第6期169-172,共4页
目的 探讨Lean-Six Sigma模型在医师资格实践技能考试考务管理中的应用,以期提高管理效率和考试的公正性,同时优化资源配置与评分机制。方法 基于Lean-Six Sigma模型的理论框架,对其在考务管理中的应用策略进行了深入分析,涉及流程优化... 目的 探讨Lean-Six Sigma模型在医师资格实践技能考试考务管理中的应用,以期提高管理效率和考试的公正性,同时优化资源配置与评分机制。方法 基于Lean-Six Sigma模型的理论框架,对其在考务管理中的应用策略进行了深入分析,涉及流程优化、数据驱动的质量控制以及持续改进机制。结果 应用Lean-Six Sigma模型能够有效简化考务流程,降低了资源消耗,从而提升工作效率。数据驱动的质量控制显著增强了评分的公正性和一致性,而持续改进机制确保了管理流程的不断优化。结论 Lean-Six Sigma模型在医师资格考试考务管理中展现出显著的应用价值,能够有效提升管理效率和考试的公正性,未来可考虑结合大数据和人工智能技术,进一步提升该模型的应用效果。 展开更多
关键词 Lean-Six Sigma模型 实践技能考试 考务管理 流程优化
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基于CNN-SIX网络的随机共振研究 认领 引用
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作者 文雅仪 杨占山 《佳木斯大学学报（自然科学版）》 CAS 2025年第12期33-36,共4页
随机共振是指在非线性系统中,当输入带噪信号时,通过调整噪声强度或系统参数,增加系统的信噪比,以优化系统的输出响应。利用改进后的卷积神经网络CNN-SIX在算力有限的情况下进行随机共振的研究。对MNIST手写数字集进行训练,分别研究高... 随机共振是指在非线性系统中,当输入带噪信号时,通过调整噪声强度或系统参数,增加系统的信噪比,以优化系统的输出响应。利用改进后的卷积神经网络CNN-SIX在算力有限的情况下进行随机共振的研究。对MNIST手写数字集进行训练,分别研究高斯噪声、均匀噪声和拉普拉斯噪声对模型的影响,同时研究在输入层和输出层加入不同类型噪声时的效果,利用交叉熵损失函数和Adam优化算法对网络进行训练,实验结果表明,CNN-SIX卷积神经网络中存在着随机共振现象,在输入层添加噪声和在输出层添加噪声均存在噪声增益,输入层的噪声增益大于输出层的噪声增益,且在输入层和输出层添加不同类型的噪声效果大于只添加单一的一种噪声。 展开更多
关键词 CNN-SIX卷积神经网络 随机共振 Adam优化算法 噪声
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Flow Control in Six-Strand Billet Continuous Casting Tundish With Different Configurations 认领 引用 被引量：18
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作者 ZHONG Liang-cai WANG Ming-an +2 位作者 CHEN Bo-yu WANG Can-rong ZHU Ying-xiong 《Journal of Iron and Steel Research International》 SCIE CAS 2010年第7期7-12,共6页
A 1∶2.5 scale tundish model was set up in laboratory for a six-strand billet continuous casting tundish with different configurations to investigate fluid flow characteristics under different operational conditions b... A 1∶2.5 scale tundish model was set up in laboratory for a six-strand billet continuous casting tundish with different configurations to investigate fluid flow characteristics under different operational conditions by measuring residence time distribution curves.It was found that minimum residence time,maximum concentration time and average residence time of the three strands on the same side of the tundish with the former configuration under normal operation,that is,six strands were open,were small and non-uniform and the tundish had large dead volume fraction.Vortexes easily formed on the liquid surface in the pouring zone of the tundish.The fluid flow characteristics in the tundish with the optimal turbulence inhibitor and baffles were improved and became less non-uniform among the strands.Vortexes were not found on the pouring zone surface in the optimal tundish.For non-normal operation,that is,one strand was close,it was important to choose which strand to be closed for maintaining flow characteristics of the rest two strands.It was found from this investigation that fluid flow characteristics in the optimal configuration tundish with closing strand 2 were better than those with closing strand 3 on the same side. 展开更多
关键词 billet continuous casting six-strand tundish flow control physical modeling operational mode
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Method for Analyzing Articulated Torques of Heavy-duty Six-legged Robot 认领 引用 被引量：11
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作者 ZHUANG Hongchao GAO Haibo +2 位作者 DING Liang LIU Zhen DENG Zongquan 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2013年第4期801-812,共12页
The accuracy of an articulated torque analysis influences the comprehensive performances of heavy-duty multi-legged robots. Currently, the extremal estimation method and some complex methods are employed to calculate ... The accuracy of an articulated torque analysis influences the comprehensive performances of heavy-duty multi-legged robots. Currently, the extremal estimation method and some complex methods are employed to calculate the articulated torques, which results in a large safety margin or a large number of calculations. To quickly obtain accurate articulated torques, an analysis method for the articulated torque is presented for an electrically driven heavy-duty six-legged robot. First, the rearmost leg that experiences the maximum normal contact force is confirmed when the robot transits a slope. Based on the ant-type and crab-type tripod gaits, the formulas of classical mechanics and MATLAB software are employed to theoretically analyze the relevant static torques of the joints. With the changes in the joint angles for the abductor joint, hip joint, and knee joint, variable tendency charts and extreme curves are obtained for the static articulated torques. Meanwhile, the maximum static articulated torques and the corresponding poses of the robot are also obtained. According to the poses of the robot under the maximum static articulated torques, ADAMS software is used to carry out a static simulation analysis. Based on the relevant simulation curves of the articulated torques, the maximum static articulated torques are acquired. A comparative analysis of the maximum static articulated torques shows that the theoretical calculation values are higher than the static simulation values, and the maximum error value is approximately 10%. The proposed method lays a foundation for quickly determining accurate articulated torques to develop heavy-duty six-legged robots. 展开更多
关键词 heavy-duty six-legged robot articulated torque MATLAB static simulation analysis ADAMS
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3D打印外科导板用于上颌all-on-six种植修复的三维精度分析 认领 引用 被引量：11
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作者 路萌萌 张建兰 +1 位作者 李明 邱憬 《东南大学学报（医学版）》 CAS 2020年第6期709-715,共7页
目的:评价3D打印外科导板用于上颌all-on-six种植修复的临床效果。方法:将40例行上颌无牙颌种植即刻修复患者随机分为两组:常规种植组22例共132枚植体,通过术前制定计划后自由手种植;导板种植组18例共108枚植体,在3D打印数字化导板辅助... 目的:评价3D打印外科导板用于上颌all-on-six种植修复的临床效果。方法:将40例行上颌无牙颌种植即刻修复患者随机分为两组:常规种植组22例共132枚植体,通过术前制定计划后自由手种植;导板种植组18例共108枚植体,在3D打印数字化导板辅助下种植。术后行锥形束CT检查并与术前设计的三维位置相匹配,对比两组植体三维位置精度以及患者对种植义齿的主观满意度。结果:两组种植体存留率均为100%。导板种植组种植后修复体端和根端垂直、水平向误差以及植入角度误差明显小于常规种植组(P<0.05),患者满意度高于常规种植组。结论:3D打印外科导板用于上颌无牙颌种植即刻修复,可提高种植体植入三维位置的精确度。 展开更多
关键词 3D打印 数字化导板 all-on-six 精度分析
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香蕉枯萎病病原菌Six同源基因的鉴定 认领 引用 被引量：7
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作者 郭立佳 杨腊英 +4 位作者 彭军 王国芬 梁昌聪 刘磊 黄俊生 《热带作物学报》 CSCD 北大核心 2013年第12期2391-2396,共6页
为鉴定香蕉枯萎病病原菌Six同源基因,通过BLASTP分析从香蕉枯萎病病原菌1号生理小种菌株N2基因组中鉴定了Six1和Six6同源基因,从4号生理小种B2菌株基因组中鉴定了Six1、Six2、Six6和Six8同源基因。采用PCR扩增从亚热带4号生理小种菌株... 为鉴定香蕉枯萎病病原菌Six同源基因,通过BLASTP分析从香蕉枯萎病病原菌1号生理小种菌株N2基因组中鉴定了Six1和Six6同源基因,从4号生理小种B2菌株基因组中鉴定了Six1、Six2、Six6和Six8同源基因。采用PCR扩增从亚热带4号生理小种菌株基因组DNA中扩增到Six7同源基因,并从其它一些1号和4号生理小种菌株基因组DNA中也扩增到了Six2和Six8同源基因。上述结果表明,不同古巴专化型菌株Six基因组成可能不同。该研究结果为进一步研究香蕉枯萎病病原菌Six基因的功能奠定了基础。 展开更多
关键词 香蕉 枯萎病 专化型 Six蛋白 尖孢镰刀菌
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Orthogonal analysis of water model study on the optimization of flow control devices in a six-strand tundish 认领 引用 被引量：21
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作者 Zhengyan Wei Yanping Bao +2 位作者 Jianhua Liu Wenxu Gong Baoming Wang 《Journal of University of Science and Technology Beijing》 2007年第2期118-124,共7页
Improper flow control devices in a multi-strand tundish can cause some problems, for example, liquid steel cannot reach every nozzle at the same time and the liquid steel in nozzles far away from the entry zone has a ... Improper flow control devices in a multi-strand tundish can cause some problems, for example, liquid steel cannot reach every nozzle at the same time and the liquid steel in nozzles far away from the entry zone has a lower temperature. The water model experiment of a six-strand tundish of Tianjin Iron ＆ Steel Co. Ltd. was performed, a new ＂U＂ type baffle was obtained, and its parameters were defined by perpendicular analysis. The ＂U＂ baffle can not only improve those imperfections, but also prolong the residence time of nonmetallic inclusions, which is good for their flotation and separation. 展开更多
关键词 six-strand tundish water model flow control devices optimization
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A rapid calculation method for predicting roll deformation of six-high rolling mill 认领 引用 被引量：3
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作者 Li Xie An-rui He Chao Liu 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2018年第9期901-909,共9页
The method to predict roll deformation precisely and efficiently is vital for the strip shape control of a six-high rolling mill. Traditional calculation methods of roll deformation, such as the finite element method ... The method to predict roll deformation precisely and efficiently is vital for the strip shape control of a six-high rolling mill. Traditional calculation methods of roll deformation, such as the finite element method and the influence function method, have been widely used due to their accuracies. However, the required calculation time is too long to be applied to the realtime control. Therefore, a rapid calculation method for predicting roll deformation of a six-high rolling mill was proposed, which employed the finite difference method to calculate the roll deflection and used a polynomial to describe the nonlinear relationship between roll flattening and roll contact pressure. Furthermore, a new correction strategy was proposed in the iteration, where the roll center flattening and the roll flattening deviation were put forward and corrected simultaneously in the iteration process according to the static equilibrium of roll. Finally, by the comparison with traditional methods, the proposed method was proved to be more efficient and it was suitable for the online calculation of the strip shape control. 展开更多
关键词 Six-high rolling mill Roll deformation Influence function method Rapid calculation method Online model
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Six-Sigma在改进冷凝器焊接过程质量中的应用 认领 引用 被引量：4
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作者 盛敬峰 于影霞 龙丹 《科技管理研究》 CSSCI 北大核心 2017年第1期133-138,共6页
针对ZY公司冷凝器焊接过程质量故障居高不下的问题,用六西格玛改进型DMAICY模型(项目界定(D)、项目测量(M)、项目分析(A)、项目改进(I)、项目控制(C)、项目收益(Y))制定一套质量业绩改进方案,并使用Minitab软件对质量数据统计分析;通过... 针对ZY公司冷凝器焊接过程质量故障居高不下的问题,用六西格玛改进型DMAICY模型(项目界定(D)、项目测量(M)、项目分析(A)、项目改进(I)、项目控制(C)、项目收益(Y))制定一套质量业绩改进方案,并使用Minitab软件对质量数据统计分析;通过案例实施,冷凝器焊接直通率由原来的91.4%上升到99.77%,六西格玛水平由1.33提升到2.84,工序能力明显增强。实证表明,DMAICY模型在焊接生产线质量改进中的应用成功实现了预期目标,产生了显著的经济收益。 展开更多
关键词 Six-Sigma DMAICY模型 焊接 质量改进
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SIX SIGMA OPTIMIZATION IN SHEET METAL FORMING BASED ON DUAL RESPONSE SURFACE MODEL 认领 引用 被引量：14
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作者 LI Yuqiang CUI Zhenshan ZHANG Dongjuan RUAN Xueyu CHEN Jun 《Chinese Journal of Mechanical Engineering》 EI CAS 2006年第2期251-255,共5页
Iterations in optimization and numerical simulation for the sheet metal forming process may lead to extensive computation. In addition, uncertainties in materials or processing parameters may have great influence on t... Iterations in optimization and numerical simulation for the sheet metal forming process may lead to extensive computation. In addition, uncertainties in materials or processing parameters may have great influence on the design quality. A six sigma optimization method is proposed, by combining the dual response surface method （DRSM） and six sigma philosophy, to save computation cost and improve reliability and robustness of parts. Using this method, statistical technology, including the design of experiment and analysis of variance, approximate model and six sigma philosophy are integrated together to achieve improved quality. Two sheet metal forming processes are provided as examples to illustrate the proposed method. 展开更多
关键词 Six sigma optimization Sheet metal forming Dual response surface
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Measurement of six degree-of-freedom ground motion by using eight accelerometers 认领 引用 被引量：1
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作者 杨振宇 沈毅 刘志言 《Earthquake Engineering and Engineering Vibration》 EI 2005年第2期229-232,共4页
A new integrated measuring system with eight force-balance accelerometers is proposed to obtain a direct measurement of six degree-of freedom （DOF） ground motions, including three rotational and three actual transla... A new integrated measuring system with eight force-balance accelerometers is proposed to obtain a direct measurement of six degree-of freedom （DOF） ground motions, including three rotational and three actual translational acceleration components without gyroscopes. In the proposed measuring system, the relationship between the output from eight force-balance accelerometer and the six DOF motion of the measuring system under an earthquake are described by differential equations. These equations are derived from the positions and directions of the eight force-balance accelerometers in the measuring system. The third-order Runge-Kutta algorithm is used to guarantee the accuracy of the numerical calculation. All the algorithms used to compute the six DOF components of the ground motion are implemented in a real-time in Digital Signal Processor （DSP）. The distortion of the measured results caused by position and direction errors of the accelerometers in the measuring system are reduced by multiplying a compensation coefficient C to the output and subtracting static zero drift from the measured results, respectively. 展开更多
关键词 six degree-of-freedom ground motion force-balance accelerometer translational acceleration rotational acceleration
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Two Definitions of Life Will Highlight on Physiological Understanding of Six Meridians 认领 引用 被引量：4
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作者 YANG Jie-zuan FANG Hui XIAO Dang-sheng 《World Journal of Integrated Traditional and Western Medicine》 2020年第1期44-51,共8页
Treatise on Cold Pathogenic Diseases is an ancient guideline for traditional Chinese medicine(TCM) clinicians which classified all diseases into six meridians.In Treatise on Cold Pathogenic Diseases, many syndromes ar... Treatise on Cold Pathogenic Diseases is an ancient guideline for traditional Chinese medicine(TCM) clinicians which classified all diseases into six meridians.In Treatise on Cold Pathogenic Diseases, many syndromes are enunciated in simple vocabularies without physiology and pathology, which is always criticized.It seems that a bridge is necessary for physiological and pathological understanding on Treatise on Cold Pathogenic Diseases.In past decade, two definition of life in cell and in our body are presented respectively.In both definitions, energy conversion is the core pathways for all organisms which can be regarded as motion of qi.Moreover, metabolism of energy agents can be seen as yang while gene expression and stem cell proliferation & differentiation(SCPD) should be seen as yin in cell and in our body respectively.The both definitions also outline the physiology and pathology of six meridians in Treatise on Cold Pathogenic Diseases, which can be unveiled as followings: taiyang meridian-elimination of energy and end metabolites;yangming meridian-acquiring energy agents;shaoyin meridian-the conversions of energy agents;taiyin meridian-new born somatic cell attending the metabolism of energy agents and then going to die;shaoyin meridian-storage and activity of stem cell;jueyin meridian-proliferation & differentiation of stem cell to produce somatic cell.These definitions will ignite new physiological and pathological understandings on Treatise on Cold Pathogenic Diseases. 展开更多
关键词 Metabolism Stem cell Yin-yang Five phases Six meridians
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Formation of six-coordinated silicon in calcium phosphosilicate xerogels assisted by polyols at low temperature and pressure 认领 引用
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作者 Ai-Ling Li Yan-Ping Ma Dong Qiu 《Chinese Chemical Letters》 SCIE CAS CSCD 2015年第6期768-772,共5页
Silicon is usually found to be four-coordinated when neighbored with oxygen. Six-coordinated silicon is only seen in samples at very specific composition or made at high temperature/pressure. In this study, we managed... Silicon is usually found to be four-coordinated when neighbored with oxygen. Six-coordinated silicon is only seen in samples at very specific composition or made at high temperature/pressure. In this study, we managed to synthesize calcium phosphosilicate xerogels containing six-coordinated silicon with the help of polyols by sol-gel method, without the need of treatment at high temperature or high pressure. Both phosphorus precursors and polyols were found to be essential for the formation of six-coordinated silicon species; in the absence of either species, only normal four-coordinated silicon was observed under otherwise identical conditions. Samples containing six-coordinated silicon sites were found to release silicon species faster than those without six-coordinated silicon sites upon dissolved in water, suggesting that six-coordinated silicon species have higher reactivity toward hydrolysis. 展开更多
关键词 Phosphosilicate Six-coordinated silicon PolyolsMAS-NMR
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Development of six sigma concurrent parameter and tolerance design method based on response surface methodology 认领 引用
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作者 张志红 何祯 《Journal of Pharmaceutical Analysis》 CAS 2008年第3期198-201,212,共4页
Using Response Surface Methodology (RSM), an optimizing model of concurrent parameter and tolerance design is proposed where response mean equals its target in the target being best. The optimizing function of the mod... Using Response Surface Methodology (RSM), an optimizing model of concurrent parameter and tolerance design is proposed where response mean equals its target in the target being best. The optimizing function of the model is the sum of quality loss and tolerance cost subjecting to the variance confidence region of which six sigma capability can be assured. An example is illustrated in order to compare the differences between the developed model and the parameter design with minimum variance. The results show that the proposed method not only achieves robustness, but also greatly reduces cost. The objectives of high quality and low cost of product and process can be achieved simultaneously by the application of six sigma concurrent parameter and tolerance design. 展开更多
关键词 six sigma concurrent parameter and tolerance design response surface methodology confidence region cost reduction
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Application of Six-minute Walk Test in Heart Transplantation Patients 认领 引用
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作者 张国林 黄文晖 +2 位作者 郭兰 刘智 吴桂兰 《South China Journal of Cardiology》 CAS 2008年第2期57-60,共4页
Objectives To analyze the six-minute walk test （6MWT） and gas exchange of 5 heart transplantation patients and to approach the variation tendency of exercise tolerance, oxygen uptake （ VO2 ） and heart rate chronot... Objectives To analyze the six-minute walk test （6MWT） and gas exchange of 5 heart transplantation patients and to approach the variation tendency of exercise tolerance, oxygen uptake （ VO2 ） and heart rate chronotropic response. Methods 5 cases of heart transplantation patients （ age 25 - 52 years） were undertaken 6MWT 6 - 30 months after operation, synchronizing gas exchanging parameters were measured by wireless portable remote sensing K4B^2 gas analyzer, 51 normal controls were compared. Results The six-minute walk distance （6MWD） of 5 patients were （592.6 ± 26.7 ） m （558 - 625 ） m, the ascending tendency during exercise was slower, the maximum heart rates were 80% ± 6% of age-predicting maximal heart rate, lower than normal control （86%） ; the end point VO2/kg were （21.8 ± 1.4 ） mL/min · kg （ 19. 94 - 23.60） mL/min · kg. Conclusions The 6WMD and VO2 of 5 patients reached normal range, but the heart rate chronotropic response and VO2 ascending tendency were slower than those of normal controls. 展开更多
关键词 six-minute walk test heart transplantation oxygen uptake heart rate chronotropic response
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Static Force Analysis of Foot of Electrically Driven Heavy-Duty Six-Legged Robot under Tripod Gait 认领 引用 被引量：5
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作者 Zhen Liu Hong-Chao Zhuang +2 位作者 Hai-Bo Gao Zong-Quan Deng Liang Ding 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2018年第4期58-72,共15页
The electrically driven six-legged robot with high carrying capacity is an indispensable equipment for planetary exploration, but it hinders its practicability because of its low efficiency of carrying energy. Meanwhi... The electrically driven six-legged robot with high carrying capacity is an indispensable equipment for planetary exploration, but it hinders its practicability because of its low efficiency of carrying energy. Meanwhile, its load capacity also affects its application range. To reduce the power consumption, increase the load to mass ratio, and improve the stability of robot, the relationship between the walking modes and the forces of feet under the tripod gait are researched for an electrically driven heavy-duty six-legged robot. Based on the configuration characteristics of electrically driven heavy-duty six-legged, the typical walking modes of robot are analyzed. The mathematical models of the normal forces of feet are respectively established under the tripod gait of typical walking modes. According to the MATLAB software, the variable tendency charts are respectively gained for the normal forces of feet. The walking experiments under the typical tripod gaits are implemented for the prototype of electrically driven heavy-duty six-legged robot. The variable tendencies of maximum normal forces of feet are acquired. The comparison results show that the theoretical and experimental data are in the same trend. The walking modes which are most available to realize the average force of distribution of each foot are confirmed. The proposed method of analyzing the relationship between the walking modes and the forces of feet can quickly determine the optimal walking mode and gait parameters under the average distribution of foot force, which is propitious to develop the excellent heavy-duty multi-legged robots with the lower power consumption, larger load to mass ratio, and higher stability. 展开更多
关键词 Electrically driven Heavy-duty six-legged robot Tripod gait Force of foot Walking mode
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Optimised Calibration Method for Six-Port Junction 认领 引用
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作者 熊祥正 廖成 肖华清 《Journal of Southwest Jiaotong University(English Edition)》 2008年第4期392-397,共6页
A dual-tone technique is used to produce multi-samples in optimising calibration of six-port junction. More accurate results are achieved by using the least-square method and excluding those samples which may cause bi... A dual-tone technique is used to produce multi-samples in optimising calibration of six-port junction. More accurate results are achieved by using the least-square method and excluding those samples which may cause bigger errors. A 0.80 -1.10 GHz microwave integrated circuit （MIC） six-port reflectometer is constructed. Nine test samples are used in the measurement. With Engen＇s calibration procedure, the difference between the HP8510 and the six-port reflectrometer is in the order of 0.20 dB/1.5° for most cases, above 0.50 dB/5.0° at boundary frequency. With the optimised method, the difference is less than 0. 10 dB/1.0° for most cases, and the biggest error is 0.42 dB/2.1° for boundary frequencies. 展开更多
关键词 Six-port junction Calibration method Dual-tone technique
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Algorithm and experiments of six-dimensional force/torque dynamic measurements based on a Stewart platform 认领 引用 被引量：16
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作者 Wen Ke Du Fuzhou Zhang Xianzhi 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2016年第6期1840-1851,共12页
Stewart platform(SP) is a promising choice for large component alignment, and interactive force measurements are a novel and significant approach for high-precision assemblies. The designed position and orientation(P&... Stewart platform(SP) is a promising choice for large component alignment, and interactive force measurements are a novel and significant approach for high-precision assemblies. The designed position and orientation(P&O) adjusting platform, based on an SP for forceorquedriven(F/T-driven) alignment, can dynamically measure interactive forces. This paper presents an analytical algorithm of measuring six-dimensional F/T based on the screw theory for accurate determination of external forces during alignment. Dynamic gravity deviations were taken into consideration and a compensation model was developed. The P&O number was optimized as well.Given the specific appearance of repeated six-dimensional F/T measurements, an approximate cone shape was used for spatial precision analysis. The magnitudes and directions of measured F/Ts can be evaluated by a set of standards, in terms of accuracy and repeatability. Experiments were also performed using a known applied load, and the proposed analytical algorithm was able to accurately predict the F/T. A comparison between precision analysis experiments with or without assembly fixtures was performed. Experimental results show that the measurement accuracy varies under different P&O sets and higher loads lead to poorer accuracy of dynamic gravity compensation. In addition, the preferable operation range has been discussed for high-precision assemblies with smaller deviations. 展开更多
关键词 Dynamic gravity compensation F/T-driven alignment Precision analysis P&O adjusting platform Six-dimensional F/T
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SIX4和miR-103a-3p在胆囊癌组织中的表达及其对胆囊癌细胞增殖和侵袭的影响 认领 引用 被引量：4
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作者 陈超 李俊霖 朱朝庚 《肝胆胰外科杂志》 CAS 2022年第10期620-627,共8页
目的 探究SIX同源盒蛋白4(SIX4)、微小RNA(miR)-103a-3p在胆囊癌组织中的表达情况,以及二者对胆囊癌细胞增殖、侵袭的影响。方法 胆囊癌组织及癌旁组织取自永州市中心医院2019年10月至2021年9月32例接受手术治疗的胆囊癌患者,并将体外... 目的 探究SIX同源盒蛋白4(SIX4)、微小RNA(miR)-103a-3p在胆囊癌组织中的表达情况,以及二者对胆囊癌细胞增殖、侵袭的影响。方法 胆囊癌组织及癌旁组织取自永州市中心医院2019年10月至2021年9月32例接受手术治疗的胆囊癌患者,并将体外培养的胆囊癌细胞系GBC-SD分为对照组、mimic NC组、miR-103a-3p mimic组、miR-103a-3p mimic+pc DNA3.1组、miR-103a-3p mimic+SIX4组。实时荧光定量PCR(qRT-PCR)检测SIX4 mRNA、miR-103a-3p水平;蛋白印迹法检测SIX4、增殖细胞核相关抗原Ki-67、增殖细胞核抗原(PCNA)以及基质金属蛋白酶(MMP)2、MMP9蛋白水平;CCK-8法检测细胞增殖情况;Transwell检测细胞侵袭情况。双荧光素酶验证SIX4 mRNA 3’UTR与miR-103a-3p的结合作用。结果 与癌旁组织相比,胆囊癌组织中SIX4 mRNA水平升高,miR-103a-3p水平降低(P<0.05)。miR-103a-3p靶向负调控SIX4。与对照组、mimic NC组比较,miR-103a-3p mimic组细胞中SIX4 mRNA和蛋白水平,OD,侵袭数量,Ki-67、PCNA、MMP2、MMP9蛋白水平降低,miR-103a-3p水平升高(P<0.05);与miR-103a-3p mimic+pc DNA3.1组比较,miR-103a-3p mimic+SIX4组上述各项指标均被逆转。结论 胆囊癌组织中SIX4水平升高、miR-103a-3p水平降低,过表达miR-103a-3p可能通过靶向抑制SIX4表达,从而抑制胆囊癌细胞增殖、侵袭。 展开更多
关键词 SIX同源盒蛋白4 微小RNA-103a-3p 胆囊癌 细胞增殖 细胞侵袭
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Optimization of Steel Bar Manufacturing Process Using Six Sigma 认领 引用 被引量：1
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作者 NAEEM Khawar ULLAH Misbah +4 位作者 TARIQ Adnan MAQSOOD Shahid AKHTAR Rehman NAWAZ Rashid HUSSAIN Iftikhar 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2016年第2期332-341,共10页
Optimization of a manufacturing process results in higher productivity and reduced wastes. Production parameters of a local steel bar manufacturing industry of Pakistan is optimized by using six Sigma-Define, measure,... Optimization of a manufacturing process results in higher productivity and reduced wastes. Production parameters of a local steel bar manufacturing industry of Pakistan is optimized by using six Sigma-Define, measure, analyze, improve, and controlmethodology. Production data is collected and analyzed. After analysis, experimental design result is used to identify significant factors affecting process performance. The significant factors are controlled to optimized level using two-level factorial design method. A regression model is developed that helps in the estimation of response under multi variable input values. Model is tested, verified, and validated by using industrial data collected at a local steel bar manufacturing industry of Peshawar（Khyber Pakhtunkhwa, Pakistan）. The sigma level of the manufacturing process is improved to 4.01 from 3.58. The novelty of the research is the identification of the significant factors along with the optimum levels that affects the process yield, and the methodology to optimize the steel bar manufacturing process. 展开更多
关键词 steel bar manufacturing industry six sigma yield sigma level design of experiments
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