We construct two conical surfaces which take non-coplanar lines as generatrix and rational Bezier curve as ridge-line, and prove that the intersecting line of conical surface has similar properties to Bezier curve. Th...We construct two conical surfaces which take non-coplanar lines as generatrix and rational Bezier curve as ridge-line, and prove that the intersecting line of conical surface has similar properties to Bezier curve. Then, the smoothly blending of two cylinders whose axes are non-coplanar is realized by taking intersecting line of conical surface as axes.展开更多
Since CAS is charged with the key task of carrying out strategic, fundamental and forward-looking studies for this country, it is incumbent upon CAS scientists to take an active part in the National Program for the De...Since CAS is charged with the key task of carrying out strategic, fundamental and forward-looking studies for this country, it is incumbent upon CAS scientists to take an active part in the National Program for the Development of Western China. This is also an important part of the national Knowledge Innovation Program (KIP) spearheaded by CAS. Over the past two years, CAS has made a series of remarkable advances in Western China with regard to the development of research bases, exploration of crucial scientific problems, the training of talented people, and providing consultation services for decision makers.With the furtherance of the national drive to develop the country's western region, CAS will step up its efforts and increase its funding, to make more and greater contributions to the overall development of the region.展开更多
At 8:30 on October 27, the first international flight from Shanghai to Singapore MU576 took off at Pudong Airport. Thus,all international flights and those to Hong Kong and Macao were all moved to Pudong Airport. Besi...At 8:30 on October 27, the first international flight from Shanghai to Singapore MU576 took off at Pudong Airport. Thus,all international flights and those to Hong Kong and Macao were all moved to Pudong Airport. Besides internationalflights and Hong Kong and Macao flights, the eastward moving also cover some domestic flights, namely flights fromSanya, Haikou, Guangzhou, Shenzhen, Zhuhai, Qingdao, Yantai, Weihai, Weifang and so on in Northwest China, Mid-South China,and East China to Shanghai. After the eastward moving, the flight distribution at two airports in Shanghai changed greatly.展开更多
In 2009, the nuclear power plants under China National Nuclear Corporation (CNNC) continuously kept reliable operation. CNNC's seven nuclear power units accumulatively generated 38.25
On laser facilities for achieving inertial confinement fusion ignition,several beams are usually bundled together and injected into the target chamber through a common port.This specific configuration could lead to la...On laser facilities for achieving inertial confinement fusion ignition,several beams are usually bundled together and injected into the target chamber through a common port.This specific configuration could lead to laser-plasma interaction(LPI)processes that are quite different from those of a single laser beam,as well as to more options for suppressing LPI via combination of different laser smoothing techniques on the beams in a bundle.For studying LPI of a bundle of beams,a novel facility named Shenguang Octopus has been developed.Recently,the first LPI experiments have been performed by axially irradiating a gas-filled glass pipe or a gold hohlraum target with the bundled eight laser beams at an overlapped intensity of~1×1015W~cm2,producing~5-mm-long homogeneous plasmas with densities of~3×1020cm-3and temperatures of 1.2-1.5 keV.Efficient laser propagation without plasma filamentation and beam spraying has been observed via side-on X-ray images of glass pipe targets.Results from the gold hohlraum targets indicate that single-beam backward stimulated Brillouin scattering(SBS)and multibeam seeded side-SBS play major roles in the interaction,while other multibeam LPI processes expected before the experiments are not observed.Several beam smoothing techniques,such as mixed polarizations,smoothing by spectral dispersion,and multicolor mode,are demonstrated to be effective in suppressing LPI under current conditions.展开更多
During mine roadway excavation in jointed and fractured rock masses,drilling and blasting remains a widely adopted method.However,the complex interaction between blasting-induced stress waves and pre-existing structur...During mine roadway excavation in jointed and fractured rock masses,drilling and blasting remains a widely adopted method.However,the complex interaction between blasting-induced stress waves and pre-existing structural planes often leads to overbreak,loosening of the surrounding rock,and an expanded excavation damage zone,posing significant challenges to roadway stability and construction safety.Most existing studies are limited to single-factor analyses or assume homogeneous rock mass behavior,leaving a critical gap in understanding the coupled effects of joint geometric parameters and blasting parameters on damage evolution.This study addresses this gap by developing a numerical model using LSDYNA to investigate blast damage control in jointed rock masses during roadway excavation.A systematic parametric analysis was conducted to evaluate the influence of joint dip angle(α),joint thickness(h),joint position,and blast-hole spacing(d)on blasting performance.The results show that atα=45°,particle vibration velocity at the monitoring points reaches its maximum,and fragmentation is most pronounced along the blast-hole connection line.Reducing the blast-hole spacing to 60 cm increases the peak effective stress at the joint plane to 72.8 MPa,yielding optimal fragmentation while mitigating excessive rock damage commonly associated with larger spacings.As joint thickness increases from 4 cm to 8 cm,the peak effective stress at the joint plane drops from 94.7 MPa to 70.8 MPa.This decrease of approximately 33.7%indicates that thicker joints substantially enhance stress-wave attenuation and energy dissipation.Moreover,increasing the distance between the joint and the blast hole from 5 cm to 15 cm significantly reduces damage in the rock mass between the source and the joint plane.Field validation demonstrates that the optimized smooth blasting scheme,compared to conventional blasting,improves the half-hole rate from 33.3%to 93.3%,increases the average advance per cycle from 2.43 m to 2.92 m,and reduces the depth of blast-induced damage from approximately 2.4 m to 1.5 m.These findings confirm that the proposed blasting parameters markedly enhance excavation quality and effectively limit blast-induced damage in jointed rock masses.展开更多
Nonprehensile transportation represents a fundamental approach in robotic manipulation widely implemented in practical applications,where object dynamics constraints must be strictly maintained.However,existing approa...Nonprehensile transportation represents a fundamental approach in robotic manipulation widely implemented in practical applications,where object dynamics constraints must be strictly maintained.However,existing approaches have certain limitations in operational reliability and control performance,particularly regarding execution efficiency and input adaptation.To address these limitations,we propose a novel shared teleoperation method for nonprehensile object transportation.The method reformulates constraints from object dynamics to robot kinematics level,eliminating the need for direct contact force control.It achieves autonomous orientation control through orientation feedforward smoothing while enabling shared position control based on user teleoperation inputs.Additionally,the coordination between position and attitude is ensured through input command optimization.The effectiveness of this method was evaluated through extensive trajectory tracking simulations and human subject experiments.The results demonstrate superiority over existing methods regarding operational safety,task efficiency,tracking accuracy,and input command adaptability.展开更多
Stony debris flows,characterized by coarse boulders embedded in a sediment-laden matrix,greatly amplify destructive potential by altering flow dynamics and impact forces.Conventional single-phase particle-fluidmixture...Stony debris flows,characterized by coarse boulders embedded in a sediment-laden matrix,greatly amplify destructive potential by altering flow dynamics and impact forces.Conventional single-phase particle-fluidmixture models often struggle to capture the complexities introduced by coarse boulders and multi-phase interactions,while strong-coupling methods can be computationally prohibitive for practical hazard assessments.In this study,we propose a semi-hybrid,fully resolved coupling numerical framework for modeling boulder-laden debris flows.This framework conceptualizes debris flows as a composite system comprising a continuous viscous fluidphase(including finesediments)and a discrete phase of arbitrarily shaped coarse particles.The continuous phase is treated as a generalized nonlinear Coulomb-viscoplastic fluidusing the smoothed particle hydrodynamics(SPH)method,while coarse particles are modeled via the distributed contact discrete element method(DCDEM).These two phases are coupled through an efficienttwo-way resolved scheme,ensuring accurate simulation of flow-boulder interactions within a unifiedtimeframe.We validate the proposed method against two physical experiments:(1)gravity-driven concrete flows and(2)debris flowinteracting with slit-type barriers.Results confirmthe method's robustness in accurately capturing fluid-solid-structureinteractions and deposition processes.Its capabilities are further showcased through the simulation of a stony debris-flowevent inWenchuan County,China,highlighting its promise for real-world engineering applications and validating the effectiveness of the existing cascade dam system in mitigating debrisflowimpact and energy dissipation.展开更多
Trajectory smoothing for connected and autonomous vehicles(CAVs)offers opportunities to improve traffic efficiency and reduce energy consumption,especially at intersections.Most previous studies in this research area ...Trajectory smoothing for connected and autonomous vehicles(CAVs)offers opportunities to improve traffic efficiency and reduce energy consumption,especially at intersections.Most previous studies in this research area only considered trajectory smoothing for a single CAV or assumed a homogenous CAV platoon.This paper proposes a trajectory-smoothing method for power-heterogeneous CAV platoons at signalized intersections.A Distributed Model Predictive Control(DMPC)algorithm was used to maintain a constant time headway for power-heterogeneous CAVs,considering the differences in capabilities between electric-and fuel-powered vehicles in terms of the inertial time lag to minimize speed fluctuations within the platoon.Additionally,a trajectory smoothing method was proposed that used CAV platoons as the minimum control unit,thus enabling well-formed platoons to pass through signalized intersections without stopping.Simulation experiments on the SUMO platform validated the effectiveness of the proposed methods compared to benchmark cases without trajectory smoothing for CAV platoons.This strategy can improve the traffic efficiency by reducing the total delay and waiting time,especially with high traffic demand.The results also indicate that this method can lead to substantial energy savings,highlighting the potential of advanced CAV technologies to contribute to more sustainable urban transportation systems.展开更多
Atherosclerosis,characterized by the formation of fibrofatty lesions in the arterial wall,remains a leading cause of global morbidity and mortality.Emerging evidence highlights the critical regulatory roles of long no...Atherosclerosis,characterized by the formation of fibrofatty lesions in the arterial wall,remains a leading cause of global morbidity and mortality.Emerging evidence highlights the critical regulatory roles of long non-coding RNAs(lncRNAs)and microRNAs(miRNAs)in atherogenesis.LncRNAs can function as competing endogenous RNAs(ceRNAs)by sponging miRNAs,thereby modulating the expression of downstream target mRNAs.This review summarizes current knowledge on lncRNA-miRNA-mRNA regulatory networks and their functional roles in the three major cell types involved in atherosclerotic plaque development:endothelial cells(ECs),vascular smooth muscle cells(VSMCs),and macrophages.In ECs,these networks are implicated in inflammation,apoptosis,proliferation,angiogenesis,pyroptosis,and autophagy.In VSMCs,they regulate proliferation,apoptosis,and migration.In macrophages,they influence lipid metabolism,inflammatory responses,oxidative stress,and autophagy.Although the ceRNA mechanism is predominant,some lncRNAs also act as primary transcripts for miRNAs.Additionally,exosome-mediated non-coding RNA delivery mediates intercellular crosstalk,further expanding the complexity of RNA-based regulation in atherosclerosis.Despite significant progress,challenges remain due to the complexity and context-specificity of these networks.Further research is essential to elucidate these mechanisms and explore their potential as therapeutic targets for atherosclerosis.展开更多
On July 19,2020,the Tanjiawan landslide in Badong County,China,underwent pronounced deformation triggered by extreme rainfall,posing substantial risks to local communities and infrastructure.To elucidate its spatiotem...On July 19,2020,the Tanjiawan landslide in Badong County,China,underwent pronounced deformation triggered by extreme rainfall,posing substantial risks to local communities and infrastructure.To elucidate its spatiotemporal evolution and failure mechanisms,a comprehensive field campaign was conducted,supported by multi-source datasets including geological,topographic,lithological,precipitation,satellite remote sensing,and unmanned aerial vehicle(UAV)-based photogrammetry.Deep learning(DL)models(U-Net and ResU-Net)were employed to automatically extract ground cracks from high-resolution UAV-based orthophotos.ResU-Net achieved superior recognition accuracy(89.7%)compared to U-Net(85.9%),with cracks predominantly distributed along the rear scarp and lateral margins,consistent with field observations.Landslide stability was evaluated using the limit equilibrium method,coupled with Monte Carlo simulations to account for parameter uncertainty.Under extreme rainfall conditions(320 mm/d),the factor of safety decreased markedly from 1.079 to 0.822,while the failure probability increased by 72.82%.The post-failure dynamics were simulated using a smoothed particle hydrodynamics(SPH)model,which predicted a total run-out duration of 48 s,a peak velocity of 28 m/s at 19 s,and an average final deposit thickness of approximately 5 m.The integrated framework demonstrates the potential of DL,probabilistic stability analysis,and particle-based modeling for quantitative landslide hazard assessment and early-warning applications in rainfall-sensitive mountainous regions.展开更多
The northern segment of the North-South Seismic Belt is characterized by intense crustal deformation,well-developed active tectonics,and frequent occurrences of strong earthquakes.Therefore,conducting a Probabilistic ...The northern segment of the North-South Seismic Belt is characterized by intense crustal deformation,well-developed active tectonics,and frequent occurrences of strong earthquakes.Therefore,conducting a Probabilistic Seismic Hazard Analysis(PSHA)for this region is of significant importance for supporting seismic fortification in major engineering projects and formulating disaster prevention and mitigation policies.In this study,a composite seismic source model was constructed by integrating data on historical earthquakes,active faults,and paleoseismicity.Furthermore,a logic tree framework was employed to quantify epistemic uncertainties,enabling a systematic seismic hazard assessment of the region.To more accurately characterize the spatial heterogeneity of seismic activity,improvements were made to both the Circular Spatial Smoothing Model(CSSM)with a fixed radius and the Adaptive Spatial Smoothing Model(ASSM),with full consideration given to the spatiotemporal completeness of historical earthquake magnitudes.Regarding the CSSM,for scenarios involving small sample sizes in earthquake catalogs,the cross-validation method proposed in this study demonstrated higher robustness than the maximum likelihood method in determining the optimal correlation distance.Performance evaluation results indicate that while both models effectively characterize seismic activity,the ASSM exhibits superior overall predictive performance compared to the CSSM,owing to its ability to adaptively adjust the smoothing radius according to seismic density.Significant discrepancies were observed in the Peak Ground Acceleration(PGA)results calculated with a 10%probability of exceedance in 50 years across different combinations of seismic source models.The single spatially smoothed point-source model yielded a maximum PGA of approximately 0.52 g,with high-value areas concentrated near historical epicenters,thereby significantly underestimating the hazard associated with major fault zones.When combined with the simple fault-source model,the maximum PGA increased to 0.8 g,with high-value zones exhibiting a zonal distribution along faults;however,the risk remained underestimated for faults with low slip rates that are nevertheless approaching their recurrence cycles.Following the introduction of the time-dependent characteristic fault-source model,local PGA values for faults in the middle-to-late stages of their recurrence cycles increased by a factor of 2 to 7 compared to the single model.These results demonstrate that the characteristic fault-source model reasonably delineates the time-dependence of large earthquake recurrence,thereby providing a more accurate assessment of imminent seismic risks.By comprehensively applying the improved spatially smoothed pointsource model,the simple fault-source model,and the characteristic fault-source model,the following faults within the region were identified as having high seismic hazard:the Huangxianggou,Zhangxian,and Tianshui segments of the Xiqinling northern edge fault;the Maqin-Maqu segment of the Dongkunlun fault;the Longriqu fault;the Maoergai fault;the Elashan fault;the Riyueshan fault;the eastern segment of the Lenglongling fault;the Maxianshan segment of the Maxianshan northern Margin fault;and the Maomaoshan-Jinqianghe segment of the Laohushan-Maomaoshan fault.As these faults are located within seismic gaps or are approaching the recurrence periods of large earthquakes,they should be prioritized for current and future seismic monitoring as well as disaster prevention and mitigation efforts.展开更多
This study presents a novel framework for evaluating slope stability in spatially variable soils by integrating a newly developed sequential limit analysis based on the Hellinger-Reissner functional,utilizing the node...This study presents a novel framework for evaluating slope stability in spatially variable soils by integrating a newly developed sequential limit analysis based on the Hellinger-Reissner functional,utilizing the node-based smoothed finite element method(NS-FEM),with a newly proposed deep learning(DL)approach termed multi-downsampling hybrid Linformer-convolutional neural networks(CNNs).The NS-FEM-based mixed formulation of limit analysis(MFLA)enhances computational accuracy and convergence by smoothing strain fields and mitigating numerical discontinuities commonly encountered in standard finite element methods(FEMs).This method generates reliable datasets for stochastic simulations of slope stability under both static and seismic loading conditions.To address the computational expense of specific simulations,we propose the multi-downsampling hybrid Linformer-CNN model,a sophisticated DL architecture that employs dual parallel pathways with distinct downsampling strategies–AveragePooling1D for medium-scale feature extraction and MaxPooling1D for coarse-scale feature extraction.Each pathway integrates one-dimensional(1D)CNNs for local feature extraction and Linformer-based self-attention mechanisms to efficiently capture global dependencies.The parallel downsampling strategies balance computational efficiency with feature granularity,enabling the model to leverage both local and global data characteristics effectively.The extracted multi-scale features are concatenated and further processed through fully connected networks(FCNs)to accurately predict the factor of safety(FoS)of slopes.Comparative analyses demonstrate that the hybrid Linformer-CNN model outperforms traditional FCN and CNN architectures,achieving robust and precise predictions with a mean absolute percentage error(MAPE)below 10%.Additionally,the proposed framework significantly reduces computational time,highlighting the potential of integrating NS-FEM-based MFLA with advanced DL architectures for rapid and reliable slope stability assessment in geotechnical engineering.展开更多
Atherosclerosis(AS)is widely recognized as the principal pathological substrate underlying chronic cardiovascular diseases(CVDs).It is a chronic,progressive,and inflammatory disease characterized by excessive lipid de...Atherosclerosis(AS)is widely recognized as the principal pathological substrate underlying chronic cardiovascular diseases(CVDs).It is a chronic,progressive,and inflammatory disease characterized by excessive lipid deposition,oxidative stress,inflammatory response,plaque formation and rupture,thrombosis and vascular calcification(VC).Vascular smooth muscle cells(VSMCs)are essential for maintaining the normal structure of blood vessels and play a pivotal role in the pathological process of AS.Their proliferation,migration,differentiation,senescence and death processes critically influence the progression of AS.The specific mechanism of VSMCs participating in AS remains a central focus of research in the cardiovascular field.In recent years,natural products have garnered considerable attention in the field of AS prevention and treatment,primarily due to their multi-target effects,low toxicity and side effects.However,there is still a lack of systematic review of natural compounds that alleviate AS by regulating the function of VSMCs.This article focuses on the core role of VSMCs in the progression of AS,and systematically reviews the natural compounds targeting VSMCs metabolism and their molecular regulatory mechanisms.By combing the relevant pharmacological activities and potential targets,the pathological function of VSMCs in AS is further elucidated,thereby providing an important theoretical basis for the development of novel and efficient AS treatment strategies.展开更多
摘要We construct two conical surfaces which take non-coplanar lines as generatrix and rational Bezier curve as ridge-line, and prove that the intersecting line of conical surface has similar properties to Bezier curve. Then, the smoothly blending of two cylinders whose axes are non-coplanar is realized by taking intersecting line of conical surface as axes.
摘要Since CAS is charged with the key task of carrying out strategic, fundamental and forward-looking studies for this country, it is incumbent upon CAS scientists to take an active part in the National Program for the Development of Western China. This is also an important part of the national Knowledge Innovation Program (KIP) spearheaded by CAS. Over the past two years, CAS has made a series of remarkable advances in Western China with regard to the development of research bases, exploration of crucial scientific problems, the training of talented people, and providing consultation services for decision makers.With the furtherance of the national drive to develop the country's western region, CAS will step up its efforts and increase its funding, to make more and greater contributions to the overall development of the region.
摘要At 8:30 on October 27, the first international flight from Shanghai to Singapore MU576 took off at Pudong Airport. Thus,all international flights and those to Hong Kong and Macao were all moved to Pudong Airport. Besides internationalflights and Hong Kong and Macao flights, the eastward moving also cover some domestic flights, namely flights fromSanya, Haikou, Guangzhou, Shenzhen, Zhuhai, Qingdao, Yantai, Weihai, Weifang and so on in Northwest China, Mid-South China,and East China to Shanghai. After the eastward moving, the flight distribution at two airports in Shanghai changed greatly.
摘要In 2009, the nuclear power plants under China National Nuclear Corporation (CNNC) continuously kept reliable operation. CNNC's seven nuclear power units accumulatively generated 38.25
基金supported by the National Security Academic Fund(Grant No.U2430207)the National Natural Science Foundation of China(Grant Nos.12275251,12275032,12375243,12375242,and 12035002)the Fund of the National Key Laboratory of Plasma Physics(Grant Nos.6142A04230103 and JCKYS2024212803).
摘要On laser facilities for achieving inertial confinement fusion ignition,several beams are usually bundled together and injected into the target chamber through a common port.This specific configuration could lead to laser-plasma interaction(LPI)processes that are quite different from those of a single laser beam,as well as to more options for suppressing LPI via combination of different laser smoothing techniques on the beams in a bundle.For studying LPI of a bundle of beams,a novel facility named Shenguang Octopus has been developed.Recently,the first LPI experiments have been performed by axially irradiating a gas-filled glass pipe or a gold hohlraum target with the bundled eight laser beams at an overlapped intensity of~1×1015W~cm2,producing~5-mm-long homogeneous plasmas with densities of~3×1020cm-3and temperatures of 1.2-1.5 keV.Efficient laser propagation without plasma filamentation and beam spraying has been observed via side-on X-ray images of glass pipe targets.Results from the gold hohlraum targets indicate that single-beam backward stimulated Brillouin scattering(SBS)and multibeam seeded side-SBS play major roles in the interaction,while other multibeam LPI processes expected before the experiments are not observed.Several beam smoothing techniques,such as mixed polarizations,smoothing by spectral dispersion,and multicolor mode,are demonstrated to be effective in suppressing LPI under current conditions.
基金funded by the National Natural Science Foundation of China (52274083, 42467023)the Special Program for Industrial Innovation Talents under Yunnan Province "Xingdian Talents Support Plan"
摘要During mine roadway excavation in jointed and fractured rock masses,drilling and blasting remains a widely adopted method.However,the complex interaction between blasting-induced stress waves and pre-existing structural planes often leads to overbreak,loosening of the surrounding rock,and an expanded excavation damage zone,posing significant challenges to roadway stability and construction safety.Most existing studies are limited to single-factor analyses or assume homogeneous rock mass behavior,leaving a critical gap in understanding the coupled effects of joint geometric parameters and blasting parameters on damage evolution.This study addresses this gap by developing a numerical model using LSDYNA to investigate blast damage control in jointed rock masses during roadway excavation.A systematic parametric analysis was conducted to evaluate the influence of joint dip angle(α),joint thickness(h),joint position,and blast-hole spacing(d)on blasting performance.The results show that atα=45°,particle vibration velocity at the monitoring points reaches its maximum,and fragmentation is most pronounced along the blast-hole connection line.Reducing the blast-hole spacing to 60 cm increases the peak effective stress at the joint plane to 72.8 MPa,yielding optimal fragmentation while mitigating excessive rock damage commonly associated with larger spacings.As joint thickness increases from 4 cm to 8 cm,the peak effective stress at the joint plane drops from 94.7 MPa to 70.8 MPa.This decrease of approximately 33.7%indicates that thicker joints substantially enhance stress-wave attenuation and energy dissipation.Moreover,increasing the distance between the joint and the blast hole from 5 cm to 15 cm significantly reduces damage in the rock mass between the source and the joint plane.Field validation demonstrates that the optimized smooth blasting scheme,compared to conventional blasting,improves the half-hole rate from 33.3%to 93.3%,increases the average advance per cycle from 2.43 m to 2.92 m,and reduces the depth of blast-induced damage from approximately 2.4 m to 1.5 m.These findings confirm that the proposed blasting parameters markedly enhance excavation quality and effectively limit blast-induced damage in jointed rock masses.
基金supported by the National Natural Science Foundation of China under the Basic Science Center Program for“Space Robot Intelligent Manipulation”(T2388101).
摘要Nonprehensile transportation represents a fundamental approach in robotic manipulation widely implemented in practical applications,where object dynamics constraints must be strictly maintained.However,existing approaches have certain limitations in operational reliability and control performance,particularly regarding execution efficiency and input adaptation.To address these limitations,we propose a novel shared teleoperation method for nonprehensile object transportation.The method reformulates constraints from object dynamics to robot kinematics level,eliminating the need for direct contact force control.It achieves autonomous orientation control through orientation feedforward smoothing while enabling shared position control based on user teleoperation inputs.Additionally,the coordination between position and attitude is ensured through input command optimization.The effectiveness of this method was evaluated through extensive trajectory tracking simulations and human subject experiments.The results demonstrate superiority over existing methods regarding operational safety,task efficiency,tracking accuracy,and input command adaptability.
基金supported by the Japan Society for the Promotion of Science(JSPS)KAKENHI(Grant Nos.JP23KK0182,JP23K26356,and JP24K00971).
摘要Stony debris flows,characterized by coarse boulders embedded in a sediment-laden matrix,greatly amplify destructive potential by altering flow dynamics and impact forces.Conventional single-phase particle-fluidmixture models often struggle to capture the complexities introduced by coarse boulders and multi-phase interactions,while strong-coupling methods can be computationally prohibitive for practical hazard assessments.In this study,we propose a semi-hybrid,fully resolved coupling numerical framework for modeling boulder-laden debris flows.This framework conceptualizes debris flows as a composite system comprising a continuous viscous fluidphase(including finesediments)and a discrete phase of arbitrarily shaped coarse particles.The continuous phase is treated as a generalized nonlinear Coulomb-viscoplastic fluidusing the smoothed particle hydrodynamics(SPH)method,while coarse particles are modeled via the distributed contact discrete element method(DCDEM).These two phases are coupled through an efficienttwo-way resolved scheme,ensuring accurate simulation of flow-boulder interactions within a unifiedtimeframe.We validate the proposed method against two physical experiments:(1)gravity-driven concrete flows and(2)debris flowinteracting with slit-type barriers.Results confirmthe method's robustness in accurately capturing fluid-solid-structureinteractions and deposition processes.Its capabilities are further showcased through the simulation of a stony debris-flowevent inWenchuan County,China,highlighting its promise for real-world engineering applications and validating the effectiveness of the existing cascade dam system in mitigating debrisflowimpact and energy dissipation.
基金supported by the National Natural Science Foundation of China(Grant No.52372296)the Changsha Science and Technology Major Special Project(Grant No.kh2301004)the Postgraduate Scientific Research Innovation Project of Changsha University of Science&Technology(Grant No.CLKYCX25104).
摘要Trajectory smoothing for connected and autonomous vehicles(CAVs)offers opportunities to improve traffic efficiency and reduce energy consumption,especially at intersections.Most previous studies in this research area only considered trajectory smoothing for a single CAV or assumed a homogenous CAV platoon.This paper proposes a trajectory-smoothing method for power-heterogeneous CAV platoons at signalized intersections.A Distributed Model Predictive Control(DMPC)algorithm was used to maintain a constant time headway for power-heterogeneous CAVs,considering the differences in capabilities between electric-and fuel-powered vehicles in terms of the inertial time lag to minimize speed fluctuations within the platoon.Additionally,a trajectory smoothing method was proposed that used CAV platoons as the minimum control unit,thus enabling well-formed platoons to pass through signalized intersections without stopping.Simulation experiments on the SUMO platform validated the effectiveness of the proposed methods compared to benchmark cases without trajectory smoothing for CAV platoons.This strategy can improve the traffic efficiency by reducing the total delay and waiting time,especially with high traffic demand.The results also indicate that this method can lead to substantial energy savings,highlighting the potential of advanced CAV technologies to contribute to more sustainable urban transportation systems.
基金supported by the National Natural Science Foundation of China(No.82360024).
摘要Atherosclerosis,characterized by the formation of fibrofatty lesions in the arterial wall,remains a leading cause of global morbidity and mortality.Emerging evidence highlights the critical regulatory roles of long non-coding RNAs(lncRNAs)and microRNAs(miRNAs)in atherogenesis.LncRNAs can function as competing endogenous RNAs(ceRNAs)by sponging miRNAs,thereby modulating the expression of downstream target mRNAs.This review summarizes current knowledge on lncRNA-miRNA-mRNA regulatory networks and their functional roles in the three major cell types involved in atherosclerotic plaque development:endothelial cells(ECs),vascular smooth muscle cells(VSMCs),and macrophages.In ECs,these networks are implicated in inflammation,apoptosis,proliferation,angiogenesis,pyroptosis,and autophagy.In VSMCs,they regulate proliferation,apoptosis,and migration.In macrophages,they influence lipid metabolism,inflammatory responses,oxidative stress,and autophagy.Although the ceRNA mechanism is predominant,some lncRNAs also act as primary transcripts for miRNAs.Additionally,exosome-mediated non-coding RNA delivery mediates intercellular crosstalk,further expanding the complexity of RNA-based regulation in atherosclerosis.Despite significant progress,challenges remain due to the complexity and context-specificity of these networks.Further research is essential to elucidate these mechanisms and explore their potential as therapeutic targets for atherosclerosis.
基金supported by the National Natural Science Foundation of China(Nos.42477170 and 42090054)the Natural Science Foundation of Hubei Province of China(No.2025AFD435).
摘要On July 19,2020,the Tanjiawan landslide in Badong County,China,underwent pronounced deformation triggered by extreme rainfall,posing substantial risks to local communities and infrastructure.To elucidate its spatiotemporal evolution and failure mechanisms,a comprehensive field campaign was conducted,supported by multi-source datasets including geological,topographic,lithological,precipitation,satellite remote sensing,and unmanned aerial vehicle(UAV)-based photogrammetry.Deep learning(DL)models(U-Net and ResU-Net)were employed to automatically extract ground cracks from high-resolution UAV-based orthophotos.ResU-Net achieved superior recognition accuracy(89.7%)compared to U-Net(85.9%),with cracks predominantly distributed along the rear scarp and lateral margins,consistent with field observations.Landslide stability was evaluated using the limit equilibrium method,coupled with Monte Carlo simulations to account for parameter uncertainty.Under extreme rainfall conditions(320 mm/d),the factor of safety decreased markedly from 1.079 to 0.822,while the failure probability increased by 72.82%.The post-failure dynamics were simulated using a smoothed particle hydrodynamics(SPH)model,which predicted a total run-out duration of 48 s,a peak velocity of 28 m/s at 19 s,and an average final deposit thickness of approximately 5 m.The integrated framework demonstrates the potential of DL,probabilistic stability analysis,and particle-based modeling for quantitative landslide hazard assessment and early-warning applications in rainfall-sensitive mountainous regions.
基金supported by the National Key R&D Program of China(No.2022YFC3003502).
摘要The northern segment of the North-South Seismic Belt is characterized by intense crustal deformation,well-developed active tectonics,and frequent occurrences of strong earthquakes.Therefore,conducting a Probabilistic Seismic Hazard Analysis(PSHA)for this region is of significant importance for supporting seismic fortification in major engineering projects and formulating disaster prevention and mitigation policies.In this study,a composite seismic source model was constructed by integrating data on historical earthquakes,active faults,and paleoseismicity.Furthermore,a logic tree framework was employed to quantify epistemic uncertainties,enabling a systematic seismic hazard assessment of the region.To more accurately characterize the spatial heterogeneity of seismic activity,improvements were made to both the Circular Spatial Smoothing Model(CSSM)with a fixed radius and the Adaptive Spatial Smoothing Model(ASSM),with full consideration given to the spatiotemporal completeness of historical earthquake magnitudes.Regarding the CSSM,for scenarios involving small sample sizes in earthquake catalogs,the cross-validation method proposed in this study demonstrated higher robustness than the maximum likelihood method in determining the optimal correlation distance.Performance evaluation results indicate that while both models effectively characterize seismic activity,the ASSM exhibits superior overall predictive performance compared to the CSSM,owing to its ability to adaptively adjust the smoothing radius according to seismic density.Significant discrepancies were observed in the Peak Ground Acceleration(PGA)results calculated with a 10%probability of exceedance in 50 years across different combinations of seismic source models.The single spatially smoothed point-source model yielded a maximum PGA of approximately 0.52 g,with high-value areas concentrated near historical epicenters,thereby significantly underestimating the hazard associated with major fault zones.When combined with the simple fault-source model,the maximum PGA increased to 0.8 g,with high-value zones exhibiting a zonal distribution along faults;however,the risk remained underestimated for faults with low slip rates that are nevertheless approaching their recurrence cycles.Following the introduction of the time-dependent characteristic fault-source model,local PGA values for faults in the middle-to-late stages of their recurrence cycles increased by a factor of 2 to 7 compared to the single model.These results demonstrate that the characteristic fault-source model reasonably delineates the time-dependence of large earthquake recurrence,thereby providing a more accurate assessment of imminent seismic risks.By comprehensively applying the improved spatially smoothed pointsource model,the simple fault-source model,and the characteristic fault-source model,the following faults within the region were identified as having high seismic hazard:the Huangxianggou,Zhangxian,and Tianshui segments of the Xiqinling northern edge fault;the Maqin-Maqu segment of the Dongkunlun fault;the Longriqu fault;the Maoergai fault;the Elashan fault;the Riyueshan fault;the eastern segment of the Lenglongling fault;the Maxianshan segment of the Maxianshan northern Margin fault;and the Maomaoshan-Jinqianghe segment of the Laohushan-Maomaoshan fault.As these faults are located within seismic gaps or are approaching the recurrence periods of large earthquakes,they should be prioritized for current and future seismic monitoring as well as disaster prevention and mitigation efforts.
摘要This study presents a novel framework for evaluating slope stability in spatially variable soils by integrating a newly developed sequential limit analysis based on the Hellinger-Reissner functional,utilizing the node-based smoothed finite element method(NS-FEM),with a newly proposed deep learning(DL)approach termed multi-downsampling hybrid Linformer-convolutional neural networks(CNNs).The NS-FEM-based mixed formulation of limit analysis(MFLA)enhances computational accuracy and convergence by smoothing strain fields and mitigating numerical discontinuities commonly encountered in standard finite element methods(FEMs).This method generates reliable datasets for stochastic simulations of slope stability under both static and seismic loading conditions.To address the computational expense of specific simulations,we propose the multi-downsampling hybrid Linformer-CNN model,a sophisticated DL architecture that employs dual parallel pathways with distinct downsampling strategies–AveragePooling1D for medium-scale feature extraction and MaxPooling1D for coarse-scale feature extraction.Each pathway integrates one-dimensional(1D)CNNs for local feature extraction and Linformer-based self-attention mechanisms to efficiently capture global dependencies.The parallel downsampling strategies balance computational efficiency with feature granularity,enabling the model to leverage both local and global data characteristics effectively.The extracted multi-scale features are concatenated and further processed through fully connected networks(FCNs)to accurately predict the factor of safety(FoS)of slopes.Comparative analyses demonstrate that the hybrid Linformer-CNN model outperforms traditional FCN and CNN architectures,achieving robust and precise predictions with a mean absolute percentage error(MAPE)below 10%.Additionally,the proposed framework significantly reduces computational time,highlighting the potential of integrating NS-FEM-based MFLA with advanced DL architectures for rapid and reliable slope stability assessment in geotechnical engineering.
基金supported by the National Key R&D Program of China(No.2022YFC3500300)Jiangsu Province Traditional Chinese Medicine Science and Technology Development Program(No.QN202426)the Youth Talent Support Project of the Jiangsu Association for Science and Technology(No.TJ-2023-053).
摘要Atherosclerosis(AS)is widely recognized as the principal pathological substrate underlying chronic cardiovascular diseases(CVDs).It is a chronic,progressive,and inflammatory disease characterized by excessive lipid deposition,oxidative stress,inflammatory response,plaque formation and rupture,thrombosis and vascular calcification(VC).Vascular smooth muscle cells(VSMCs)are essential for maintaining the normal structure of blood vessels and play a pivotal role in the pathological process of AS.Their proliferation,migration,differentiation,senescence and death processes critically influence the progression of AS.The specific mechanism of VSMCs participating in AS remains a central focus of research in the cardiovascular field.In recent years,natural products have garnered considerable attention in the field of AS prevention and treatment,primarily due to their multi-target effects,low toxicity and side effects.However,there is still a lack of systematic review of natural compounds that alleviate AS by regulating the function of VSMCs.This article focuses on the core role of VSMCs in the progression of AS,and systematically reviews the natural compounds targeting VSMCs metabolism and their molecular regulatory mechanisms.By combing the relevant pharmacological activities and potential targets,the pathological function of VSMCs in AS is further elucidated,thereby providing an important theoretical basis for the development of novel and efficient AS treatment strategies.