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Revealing effect of Sn on the mechanical properties of resistance spot welds for 460 MPa grade HSLA steel 认领 引用
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作者 Zhaoqi Song Haitao Zhao +8 位作者 Kaixun Wang Long Ma Junheng Gao Honghui Wu Yuhe Huang Chaolei Zhang Jun Lu Shuize Wang Xinping Mao 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2026年第3期874-887,共14页
Driven by efforts toward carbon-neutral steelmaking,increased scrap usage elevates Sn content in steels.While the general effects of Sn on steel have been studied,its specific influence on resistance spot welding(RSW)... Driven by efforts toward carbon-neutral steelmaking,increased scrap usage elevates Sn content in steels.While the general effects of Sn on steel have been studied,its specific influence on resistance spot welding(RSW)remains unclear.This study investigates Sn’s impact on the mechanical properties of RSW joint of 460 MPa HSLA steel.Cross-tension tests reveal that both the RSW joint without Sn and the RSW joint·containing 0.09wt%Sn exhibit pull-out failure.The RSW joint containing 0.09wt%Sn showing higher peak load and energy absorption attributed to Sn’s solid–solution strengthening.Conversely,the RSW joint containing 0.52wt%Sn exhibited the partial interface failure mode,significantly reducing the peak load and energy absorption.The primary reason is the segregation of Sn in the interdendritic regions of the fusion zone,which weakens atomic cohesion and reduces fracture toughness.Such severe segregation arises from RSW’s high cooling rates,which shift the primary solidification phase from δ-ferrite to austenite.Fortunately,double-pulse RSW mitigates Sn segregation,restoring failure mode and mechanical performance.This study assesses the impact of Sn on RSW joint properties,and these findings highlight the broader significance of understanding scrap-related residual element effects in sustainable steel production. 展开更多
关键词 Sn failure mode segregation fracture toughness resistance spot welding
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Fine mapping of the major QTL qLLS.A02.1 and identification of a novel NBS-LRR gene cluster associated with late leaf spot resistance in peanut(Arachis hypogaea L.) 认领 引用
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作者 Huadong Li Lu Luo +9 位作者 Hui Yang Xing Li Yuying Li Haiyang Yu Kun Zhang Yuanjie Dong Benjun Hou Penghui Miao Yongshan Wan Fengzhen Liu 《The Crop Journal》 SCIE CSCD 2026年第2期547-555,共9页
Late leaf spot(LLS)is a major foliar disease that significantly reduces yield and compromises the quality of peanut(Arachis hypogaea L.).To identify genes conferring LLS resistance,a recombinant inbred line(RIL)popula... Late leaf spot(LLS)is a major foliar disease that significantly reduces yield and compromises the quality of peanut(Arachis hypogaea L.).To identify genes conferring LLS resistance,a recombinant inbred line(RIL)population of 257 lines from a cross between the susceptible cultivar Baisha 1016 and the resistant germplasm ICGV 86699 was analyzed using whole-genome resequencing.A high-density genetic map was constructed with 4908 bin markers,leading to the identification of 19 quantitative trait loci(QTL)for LLS resistance.A major QTL,qLLS.A02.1,was consistently detected on chromosome A02 across six environments,explaining up to 37.49%of the phenotypic variance.Fine mapping delimited the qLLS.A02.1 locus to a 319 kb region flanked by KASP markers S4 and S5,which contained a cluster of ten NBS-LRR genes.Validation in 266 accessions confirmed a significant association of these flanking markers with LLS resistance.Transcriptome analysis revealed that four NBS-LRR genes within the cluster were specifically upregulated in the resistant parent.This study provides valuable genetic resources and molecular markers for breeding LLS-resistant peanut varieties. 展开更多
关键词 Peanut Late leaf spot Whole-genome resequencing Quantitative trait loci Fine mapping
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VP39A is a novel host cellular binding protein of white spot syndrome virus and interacts with Na+,K+-ATPase alpha subunit 认领 引用
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作者 Zengzhi YUAN Wei OUYANG +3 位作者 Xinyi JIANG Dan ZOU Xuhui KONG Jinsheng SUN 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2026年第2期890-903,共14页
White spot syndrome virus(WSSV)is one of the most virulent pathogens in shrimp aquaculture.An in-depth understanding of the surface protein-protein interplays between WSSV and host is the key to further elucidating th... White spot syndrome virus(WSSV)is one of the most virulent pathogens in shrimp aquaculture.An in-depth understanding of the surface protein-protein interplays between WSSV and host is the key to further elucidating the pathogenesis mechanism.In this study,VP39A was identified as a novel cellular binding protein of WSSV by reversely conducting the biotinylation based affinity chromatography(BBAC)method.The result of indirect immunofluorescence assay,competitive ELISA,and in-vivo neutralization assays show that VP39A is vital to the cellular entry and infection of WSSV.Na+,K+-ATPase alpha subunit(NKAα),a trans-membrane subunit of complex Na+,K+-ATPase,was captured as the VP39A binding protein with pull-down assay.Co-localization of NKAαwith VP39A in shrimp hemocytes was confirmed by immunofluorescence and co-immunoprecipitation studies.In addition,blocking with anti-NKAαantibody can reduce the binding of WSSV to the gill cellular membrane proteins.These results collectively demonstrate that VP39A plays an important role in the viral adsorption via its interaction with NKAα,which could be an effective target for drug design. 展开更多
关键词 white spot syndrome virus(WSSV) biotinylation viral adhesion protein-protein interaction Na+,K+-ATPase alpha subunit
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Time Delay Estimation of Target Echo Signal Based on Multi-bright Spot Echoes 认领 引用
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作者 Ge Yu Fan Du +1 位作者 Xiukun Li Yan Li 《哈尔滨工程大学学报（英文版）》 CSCD 2026年第1期312-325,共14页
Accurate time delay estimation of target echo signals is a critical component of underwater target localization.In active sonar systems,echo signal processing is vulnerable to the effects of reverberation and noise in... Accurate time delay estimation of target echo signals is a critical component of underwater target localization.In active sonar systems,echo signal processing is vulnerable to the effects of reverberation and noise in the maritime environment.This paper proposes a novel method for estimating target time delay using multi-bright spot echoes,assuming the target’s size and depth are known.Aiming to effectively enhance the extraction of geometric features from the target echoes and mitigate the impact of reverberation and noise,the proposed approach employs the fractional order Fourier transform-frequency sliced wavelet transform to extract multi-bright spot echoes.Using the highlighting model theory and the target size information,an observation matrix is constructed to represent multi-angle incident signals and obtain the theoretical scattered echo signals from different angles.Aiming to accurately estimate the target’s time delay,waveform similarity coefficients and mean square error values between the theoretical return signals and received signals are computed across various incident angles and time delays.Simulation results show that,compared to the conventional matched filter,the proposed algorithm reduces the relative error by 65.9%-91.5%at a signal-to noise ratio of-25 dB,and by 66.7%-88.9%at a signal-to-reverberation ratio of−10 dB.This algorithm provides a new approach for the precise localization of submerged targets in shallow water environments. 展开更多
关键词 Multi-bright spot echoes Time-delay estimation Target echo signal Frequency sliced wavelet transform Fractional order fourier transform
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A Blind Spot in Post-Liver Transplant Care:Correlation and Causation in Immunosuppression,Drug Monitoring,and Immune Checkpoint Inhibitor-Related Rejection 认领 引用
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作者 Björn Nashan 《Health Care Science》 CSCD 2026年第3期169-173,共5页
Correlation describes a relationship between two variables,where a change in one is associated with a change in the other,but it does not prove a cause-and-effect relationship.Causation,by contrast,means that a change... Correlation describes a relationship between two variables,where a change in one is associated with a change in the other,but it does not prove a cause-and-effect relationship.Causation,by contrast,means that a change in one variable directly pro-duces or influences a change in the other.The well-known principle that“correlation does not imply causation”under-scores that two events occurring together do not necessarily indicate that one causes the other-both could be influenced by a third,unobserved factor. 展开更多
关键词 post liver transplant immune checkpoint inhibitor blind spot correlation causation immunosuppression drug monitoring two events occurring together
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Genetic Diversity of Gray Leaf Spot Pathogen on Dictamnus dasycarpus in Heilongjiang Province 认领 引用
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作者 Zhang Junhua Ren Rui +8 位作者 Yang Xin Tian Ziyu Zhao Guohui Han Songhan Zhang Yifei Wu Jiaju Xu Xiaofeng Ni Zhe Yang Mingxiu 《Journal of Northeast Agricultural University(English Edition)》 CAS 2026年第1期1-10,共10页
To ascertain the genetic diversity of gray leaf spot pathogen on Dictamnus dasycarpus popoulation in Heilongjiang Province,a total of 57 strains of Paracercospora dictamnicola were isolated and purified from the disea... To ascertain the genetic diversity of gray leaf spot pathogen on Dictamnus dasycarpus popoulation in Heilongjiang Province,a total of 57 strains of Paracercospora dictamnicola were isolated and purified from the diseased samples collected from five Chinese herbal medicine planting areas in Heilongjiang Province between the years of 2021 and 2022.Repetitive extragenic palindromic polymerase chain reaction(Rep–PCR)was used to amplify 57 isolates of gray leaf spot pathogen on D.dasycarpus from different regions of Heilongjiang Province.The polymorphic bands amplified by three sets of primers accounted for more than 80%.Cluster analysis results showed that at a similarity coefficient of 0.67,the gray leaf spot pathogen on D.dasycarpus in Heilongjiang Province could be divided into five major genetic groups.Genetic diversity parameter analysis indicated that there were certain differences in genetic richness among the geographic populations of gray leaf spot pathogen on D.dasycarpus from different regions.Analysis of molecular variance(AMOVA)revealed that genetic variation among strains mainly originated within populations.The genetic differentiation and relationships of gray leaf spot pathogen on D.dasycarpus from different geographic regions of Heilongjiang Province indicated that genetic differentiation and kinship among populations were somewhat related to their geographic distance.The greater the geographic distance,the higher the genetic differentiation coefficient,and the lower the genetic uniformity among populations. 展开更多
关键词 genetic diversity gray leaf spot repetitive extragenic palindromic polymerase chain reaction(Rep-PCR) cluster analysis analysis of molecular variance
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Microstructure evolution and corrosion behavior of refill friction stir spot welding joint for dissimilar Al alloys 认领 引用 被引量：1
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作者 Fang-yuan JIANG Da ZHANG +3 位作者 Yan-kun MA Jiang-tao XIONG Wei GUO Jing-long LI 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2026年第1期80-95,共16页
The dissimilar 2B06 and 7B04 Al alloy joints were prepared by refill friction stir spot welding(RFSSW),and the microstructural evolution and corrosion behavior of the joints were investigated.Based on microstructural ... The dissimilar 2B06 and 7B04 Al alloy joints were prepared by refill friction stir spot welding(RFSSW),and the microstructural evolution and corrosion behavior of the joints were investigated.Based on microstructural analysis,the welded joints exhibit distinct microstructural zones,including the stir zone(SZ),thermomechanically affected zone(TMAZ),and heat-affected zone(HAZ).The grain size of each zone is in the order of HAZ>TMAZ>SZ.Notably,the TMAZ and HAZ contain significantly larger secondary-phase particles compared to the SZ,with particle size in the HAZ increasing at higher rotational speeds.Electrochemical tests indicate that corrosion susceptibility follows the sequence of HAZ>TMAZ>SZ>BM,with greater sensitivity observed at increased rotational speeds.Post-corrosion mechanical performance degradation primarily arises from crevice corrosion at joint overlaps,but not from the changes in the microstructure. 展开更多
关键词 refill friction stir spot welding high strength Al alloy dissimilar joint microstructure evolution corrosion behavior
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Failure mechanism and quality evaluation in micro-resistance spot welds of braided Ag-plated Cu conductor to Cu interconnector 认领 引用
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作者 Qiang SONG Yujun XIA +4 位作者 Wenjie WANG Miaomiao QI Yunfan ZHOU Huihong LIU Yongbing LI 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第5期593-608,共16页
The service stability of flexible solar arrays relies on high-quality joints between braided Cu conductors and ultrathin interconnectors,which can be efficiently achieved through MicroResistance Spot Welding(MRSW)proc... The service stability of flexible solar arrays relies on high-quality joints between braided Cu conductors and ultrathin interconnectors,which can be efficiently achieved through MicroResistance Spot Welding(MRSW)process.However,this unconventional MRSW joint,due to the discrete and multi-body nature of braided conductor,possesses a morphology that significantly differs from traditional Resistance Spot Welding(RSW)joints,resulting in a lack of effective standards for evaluating its mechanical performance,thereby hindering its widespread application in large-scale manufacturing.We introduce a double-sided MRSW process for joining Ag-plated Cu conductors and Cu interconnectors and,for the first time,propose a quantitative evaluation method to elucidate the failure process and fracture mechanisms of these discrete,complex joints.The approach entails the analysis of the macro-and micro-structures of the joints under different heat inputs to clarify the bonding mechanism evolution:from single solid-state bonding interfaces to composite interfaces of brazing and solid-state bonding,and eventually to the composite of fusion zone and brazing interfaces.The corresponding failure modes transitioned from interfacial fracture to irregular plug fracture and ultimately to plug fracture.In light of these findings,a critical quality indicator dominated by fusion and brazing connections was identified,and a quantitative mechanical performance evaluation model based on the valid connection length of the joint was established.Experimental results demonstrate that the proposed model accurately predicted bonding strength based on the joint quality indicator,achieving a Root Mean Square Error(RMSE)of 2.736 N for peak shear strength prediction.This study paves the way for developing quality assessment criteria for MRSW joints between braided Ag-plated Cu conductors and Cu interconnectors. 展开更多
关键词 Braided structure Fracture mechanism Interfacial bonding mechanism Micro-resistance spot welding Quality evaluation
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Statistical properties of small-scale auroral spots near magnetic local noon 认领 引用
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作者 HaoYang Chen DeSheng Han +3 位作者 TianShu Fan ZhiWei Wang JianJun Liu TianRan Sun 《Earth and Planetary Physics》 EI CSCD 2026年第4期605-612,共8页
Small-scale auroral spots(SsAS)are frequently observed,particularly on the nightside,yet their formation mechanisms remain unclear.Utilizing all-sky imager data from the Chinese Arctic Yellow River Station and radar m... Small-scale auroral spots(SsAS)are frequently observed,particularly on the nightside,yet their formation mechanisms remain unclear.Utilizing all-sky imager data from the Chinese Arctic Yellow River Station and radar measurements from the European Incoherent Scatter Scientific Association(EISCAT),we identified 65 SsAS events occurring near magnetic local noon from 2003 to 2009.We found that they are observed only in the 557.7 nm emission band.They can be classified into two types based on their morphology:sporadic SsAS and fence-like SsAS.The occurrence of these events shows clear dependence on the southward interplanetary magnetic field(IMF)Bz,with the fence-like SsAS exhibiting an even more pronounced dependence.Their occurrence also depends on the westward IMF By.Additionally,we found that most events(88%)are located on the poleward side of the auroral oval,and the drift motion of these SsAS is consistent with the motion direction of adjacent auroral structures,whose motion is strictly governed by the IMF By polarity.These observations indicate that generation of these dayside SsAS may be directly linked to the solar wind energy input through magnetopause reconnection.The EISCAT observations further show that SsAS are accompanied by pronounced electron density gradients.On the basis of these characteristics,we propose that the generation of SsAS may be related to phase mixing of Alfvén waves arising from the density gradients.This study helps elucidate the coupling chain by which solar wind energy is injected into the polar region and subsequently drives ionospheric responses. 展开更多
关键词 small-scale auroral spots magnetic local noon interplanetary magnetic field Alfvén waves density gradient
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Repair of through holes in aluminum alloy plates using synergistically double-sided probeless friction stir spot welding 认领 引用
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作者 Xijie Wang Wenya Li +2 位作者 Yu Su Weibing Wang Achilles Vairis 《China Welding》 CAS 2026年第2期42-49,共8页
This study for the first time used synergistically double-sided probeless friction stir spot welding(SDP-FSSW)to repair the hole defects in a die-cast aluminum alloy ADC12 joints.Compared with conventional FSW repair ... This study for the first time used synergistically double-sided probeless friction stir spot welding(SDP-FSSW)to repair the hole defects in a die-cast aluminum alloy ADC12 joints.Compared with conventional FSW repair methods,SDP-FSSW enables symmetric material flow from both sides without a probe,thereby promoting efficient defect closure while avoiding residual keyhole defects.Experiments showed that complete filling of holes could be achieved for joints(repaired zone)welded at a rotation speed of 1500 rpm,dwell time of 4 s,and plunge depth of 0.3 mm.When the rotation speed or dwell time increased,the flash height increased as well,while joint thickness decreased,and the grains refined in the joint.At low heat-input parameters,repair relies on fine-grain filling,while at high heat-input parameters,it depends mainly on material flow.The hardness distribution of the joint shifts from“W”to“U”shape as the heat input increases.The increase in rotation speed or dwell time produced lower joint hardness. 展开更多
关键词 Probeless friction stir spot welding Die casting aluminum alloy Through hole Repair Microstructure Microhardness
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Adaptability Analysis of Dual Clearing Systems in Spot Electricity Markets Based on Fuzzy Evaluation Metrics:An Inner Mongolia Case Study 认领 引用
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作者 Kai Xie Shaoqing Yuan +4 位作者 Dayun Zou Jinran Wang Genjun Chen Ciwei Gao Yinghao Cao 《Energy Engineering》 EI 2026年第2期348-368,共21页
The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt ... The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt a single-system architecture,with research focusing primarily on accelerating solution algorithms through techniques such as high-efficiency parallel solvers and staggered decomposition of mixed-integer programming models.Notably absent are systematic studies evaluating the adaptability of primary-backup clearing systems incontingency scenarios—a critical gap given redundant systems’expanding applications in operational environments.This paper proposes a comprehensive evaluation framework for analyzing dual-system adaptability,demonstrated through an in-depth case study of the Inner Mongolia power market.First,we establish the innovative“Dual-Active Heterogeneous”architecture that enables independent parallelized operation and fault-isolated redundancy.Subsequently,key performance indices are quantitatively evaluated across four critical dimensions:unit commitment decisions,generator output constraints,transmission section congestion patterns,and clearing price formation mechanisms.An integrated fuzzy evaluation methodology incorporating grey relational analysis is employed for objective indicator weighting,enabling systematic quantification of system superiority under specific grid operating states.Empirical results based on actual operational data from 200 generation units demonstrate the framework’s efficacy in guiding optimal system selection,with particularly strong performance observed during peak load periods.The proposed approach shows high generalization potential for other regional markets employing redundant clearing mechanisms—particularly those with increasing renewable penetration and associated uncertainty. 展开更多
关键词 Spot electricity markets dual clearing systems fuzzy comprehensive evaluation system adaptability primary-backup switching
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Keyword Spotting Based on Dual-Branch Broadcast Residual and Time-Frequency Coordinate Attention 认领 引用
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作者 Zeyu Wang Jian-Hong Wang Kuo-Chun Hsu 《Computers, Materials & Continua》 SCIE EI 2026年第4期333-352,共20页
In daily life,keyword spotting plays an important role in human-computer interaction.However,noise often interferes with the extraction of time-frequency information,and achieving both computational efficiency and rec... In daily life,keyword spotting plays an important role in human-computer interaction.However,noise often interferes with the extraction of time-frequency information,and achieving both computational efficiency and recognition accuracy on resource-constrained devices such as mobile terminals remains a major challenge.To address this,we propose a novel time-frequency dual-branch parallel residual network,which integrates a Dual-Branch Broadcast Residual module and a Time-Frequency Coordinate Attention module.The time-domain and frequency-domain branches are designed in parallel to independently extract temporal and spectral features,effectively avoiding the potential information loss caused by serial stacking,while enhancing information flow and multi-scale feature fusion.In terms of training strategy,a curriculum learning approach is introduced to progressively improve model robustness fromeasy to difficult tasks.Experimental results demonstrate that the proposed method consistently outperforms existing lightweight models under various signal-to-noise ratio(SNR)conditions,achieving superior far-field recognition performance on the Google Speech Commands V2 dataset.Notably,the model maintains stable performance even in low-SNR environments such as–10 dB,and generalizes well to unseen SNR conditions during training,validating its robustness to novel noise scenarios.Furthermore,the proposed model exhibits significantly fewer parameters,making it highly suitable for deployment on resource-limited devices.Overall,the model achieves a favorable balance between performance and parameter efficiency,demonstrating strong potential for practical applications. 展开更多
关键词 Keyword spotting convolutional neural network residual learning attention small footprint noisy far-field
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甲状腺激素应答蛋白Spot 14、尿激酶型纤溶酶原激活物、E26转录因子变异体4与甲状腺乳头状癌颈部淋巴结转移的相关性及预后评估价值 认领 引用
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作者 赵庆楠 何代玉 +1 位作者 孙笑尘 金丽军 《临床外科杂志》 2026年第3期272-276,共5页
目的分析甲状腺激素应答蛋白Spot 14(THRSP)、尿激酶型纤溶酶原激活物(PLAU)、E26转录因子变异体4(ETV4)与甲状腺乳头状癌(PTC)颈部淋巴结转移的相关性及预后评估价值。方法2017年7月~2021年6月收治的PTC病人108例,使用免疫组化法检测... 目的分析甲状腺激素应答蛋白Spot 14(THRSP)、尿激酶型纤溶酶原激活物(PLAU)、E26转录因子变异体4(ETV4)与甲状腺乳头状癌(PTC)颈部淋巴结转移的相关性及预后评估价值。方法2017年7月~2021年6月收治的PTC病人108例,使用免疫组化法检测癌组织与癌旁组织THRSP、PLAU、ETV4表达,采用Kaplan-Meier曲线分析THRSP、PLAU、ETV4的表达水平与PTC病人预后的关系,采用Cox回归分析影响PTC病人预后不良的因素。结果PTC病人癌组织中THRSP、PLAU、ETV4的阳性表达率分别60.19%、62.04%、56.48%,高于癌旁组织的37.04%、39.81%、37.96%,两组比较差异有统计学意义(P<0.05),伴有淋巴结转移的PTC病人上述指标的阳性表达率分别为80.77%、80.77%、76.92%,高于无淋巴结转移的53.66%、56.10%、50.00%,两组比较差异有统计学意义(P<0.05)。Kaplan-Meier分析结果显示,THRSP、PLAU、ETV4阳性表达组的3年无进展生存率分别为60.00%、59.70%和60.66%,低于阴性表达组的88.37%、90.24%和85.11%,两组比较差异有统计学意义(P<0.05)。预后良好组的淋巴结转移比例、THRSP、PLAU、ETV4表达阳性率分别为12.99%、50.65%、51.95%和48.05%,低于预后不良组的51.61%、83.87%、87.10%和77.42%,两组比较差异有统计学意义(P<0.05)。Cox分析显示,淋巴结转移(HR=3.736,95%CI 1.669~8.361),THRSP(HR=3.218,95%CI 1.366~7.578)、PLAU(HR=3.567,95%CI 1.548~8.221)、ETV4(HR=4.103,95%CI 1.348~12.491)是影响PTC病人预后不良的重要因素(P<0.05)。结论PTC病人癌组织THRSP、PLAU、ETV4呈阳性表达,THRSP、PLAU、ETV4阳性表达PTC病人的3年生存率较低,三者的表达与颈部淋巴结转移以及预后相关。 展开更多
关键词 甲状腺激素应答蛋白Spot 14 尿激酶型纤溶酶原激活物 E26转录因子变异体4 甲状腺乳头状癌 部淋巴结转移 预后
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Isolated right ventricular non-compaction in a post-MI elderly patient:a diagnostic blind spot in geriatric cardiology 认领 引用
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作者 Andrea Elia Gian Luca Iannuzzi 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2026年第5期322-325,共4页
Isolated Ventricular Non-Compaction(IVNC)is characterized by prominent trabeculations and deep intertrabecular recesses in the ventricular myocardium,[1]believed to result from arrested myocardial compaction during em... Isolated Ventricular Non-Compaction(IVNC)is characterized by prominent trabeculations and deep intertrabecular recesses in the ventricular myocardium,[1]believed to result from arrested myocardial compaction during embryogenesis.[2,3]While most literature focuses on left ventricular non-compaction(LVNC),[4,5]isolated involvement of the right ventricle(IRVNC)[6-9]is underreported. 展开更多
关键词 Isolated Right Ventricular Non Compaction arrested myocardial compaction Diagnostic Blind Spot ventricular myocardium believed Geriatric Cardiology Embryogenesis Ventricular Non Compaction trabeculations deep intertrabecular recesses
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产业链供应链网络的构建与分析——SPOT框架 认领 引用
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作者 吴肖乐 《管理科学学报》 CSSCI CSCD 北大核心 2026年第6期1-14,共14页
传统对产业链供应链生态网络的分析多基于产品和服务等的供应关系,然而企业间的链接除了供应关系,还包括股权投资和技术合作等.对企业股权网络的穿透分析有助于判断企业代表的利益、供应的稳定性与可靠性;对于技术网络的分析则可以前瞻... 传统对产业链供应链生态网络的分析多基于产品和服务等的供应关系,然而企业间的链接除了供应关系,还包括股权投资和技术合作等.对企业股权网络的穿透分析有助于判断企业代表的利益、供应的稳定性与可靠性;对于技术网络的分析则可以前瞻性判断企业的技术潜力、技术的替代性等.为了更全面地分析产业链供应链生态网络,本研究提出了基于供应网络、产品网络、股权网络、技术网络的SPOT框架,以指导产业链供应链网络的构建.现有的研究和应用多基于一张网络,而SPOT框架强调四张网络的链接与融合分析.本研究阐述了SPOT框架构建所需的数据来源、构建方法,其在中宏观产业层级的应用以及微观企业层级的应用.此外,本研究也探讨了SPOT框架对于学界研究的启发意义. 展开更多
关键词 SPOT框架 产业链供应链 生态网络 供应网络 产品网络 股权网络 技术网络
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TB-LAMP与T-SPOT.TB诊断结核病的一致性及联合诊断准确率影响因素 认领 引用
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作者 安晓颖 刘美 +2 位作者 陈佳琪 张云婷 贾涤静 《现代预防医学》 CAS 北大核心 2026年第10期1914-1920,共7页
目的分析结核分枝杆菌环介导等温扩增技术(Mycobacterium tuberculosis loop-mediated isothermal amplification,TB-LAMP)与结核感染T细胞斑点试验(tuberculous infection of T cells spot test,T-SPOT.TB)在结核病(tuberculosis,TB)... 目的分析结核分枝杆菌环介导等温扩增技术(Mycobacterium tuberculosis loop-mediated isothermal amplification,TB-LAMP)与结核感染T细胞斑点试验(tuberculous infection of T cells spot test,T-SPOT.TB)在结核病(tuberculosis,TB)诊断中的一致性及联合诊断准确率的影响因素。方法选取2022年1月至2024年12月于我院住院治疗556例的疑似TB患者。采用受试者工作特征(receiver operating characteristic,ROC)曲线衡量两种方法单独及联合检测的诊断价值;Kappa检验评估两种方法与MTB的一致性;单因素及多因素logistic回归分析影响两种方法联合检测准确率的因素。结果三组的TB-LAMP阳性率分别为87.32%、75.00%、12.23%,T-SPOT.TB阳性率分别为92.39%、71.74%、23.40%,联合检测阳性率分别为93.48%、85.87%、18.09%,组间均有差异(P2 h、镜检不合格是影响联合诊断准确率的独立危险因素(P2 h、镜检不合格均为影响联合诊断准确率的独立危险因素。 展开更多
关键词 结核分枝杆菌环介导等温扩增技术 结核感染T细胞斑点试验 结核病诊断 一致性分析 联合诊断
Macular cherry-red spot in sialidosis type 1:a case report and literature review 认领 引用
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作者 Deming Wang Wenjing Yin Xiufeng Zhong 《Eye Science》 2026年第2期125-136,共12页
Sialidosis type 1 is a rare autosomal recessive lysosomal storage disorder.It is caused by mutations in the NEU1 gene,which lead to a deficiency of alpha-N-acetyl neuraminidase.This disease usually shows up in childho... Sialidosis type 1 is a rare autosomal recessive lysosomal storage disorder.It is caused by mutations in the NEU1 gene,which lead to a deficiency of alpha-N-acetyl neuraminidase.This disease usually shows up in childhood or adolescence with neurological and ophthalmic symptoms.The most wellknown eye symptom is macular cherry-red spots,but there is little detailed information about eyerelated characteristics.A patient came in with reduced visual acuity,night blindness,abnormal color vision,and neurological problems.An examination of the fundus showed bilateral macular cherry-red spots,temporal optic disc pallor,and hyperautofluorescent rings around the fovea.Optical coherence tomography showed increased macular reflectivity and unclear boundaries between the ganglion cell layer and the nerve fiber layer.Fundus autofluorescence confirmed pericentral hyperautofluorescence.Microperimetry showed reduced retinal sensitivity,and visual evoked potential showed prolonged P100 latency and decreased amplitude.Genetic testing found compound heterozygous pathogenic NEU1 mutations,confirming sialidosis type 1.We also reviewed published cases.Among 85 patients,23.0%first went to ophthalmology clinics.Besides cherry-red spots,lens opacities(62.1%),nystagmus(38.2%),and optic atrophy(32.0%)were common.The c.544A>G variant was the most common one,and it was associated with higher rates of lens opacities(71.4%)and visual evoked potential abnormalities(96.4%).We report the first case of sialidosis type 1 with a comprehensive multimodal ophthalmic and genetic evaluation,as well as the first systematic review of its eye manifestations.Early and complete eye examinations,including multimodal imaging and functional assessment,are very important for timely diagnosis and management of sialidosis type 1.Clinicians should be aware that there are many eye problems associated with this disease besides cherry-red spots,such as cataract,nystagmus,and optic atrophy. 展开更多
关键词 sialidosis type 1 macular cherry-red spot optical coherence tomography visual evoked potential
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Association of the tomato co-chaperone gene Sldnaj harboring a promoter deletion with susceptibility to Tomato spotted wilt virus(TSWV) 认领 引用 被引量：1
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作者 Shiming Qi Liang Zhe Meng +13 位作者 Qianqi Lou Yushun Li Yuanbo Shen Shijie Zhang Xinyu Wang Pan Zhao Jin Wang Bo Wang Xiubin Chen Chunmei Zhang Yu Du Jiantao Zhao Xiangqiang Zhan Yan Liang 《Horticulture Research》 SCIE CSCD 2025年第4期330-342,共13页
Tomato spotted wilt virus(TSWV)poses a significant threat as a devastating pathogen to the global production and quality of tomato(Solanum lycopersicum).Mining novel resistance genes within the tomato germplasm is an ... Tomato spotted wilt virus(TSWV)poses a significant threat as a devastating pathogen to the global production and quality of tomato(Solanum lycopersicum).Mining novel resistance genes within the tomato germplasm is an effective and environmentally friendly approach to combat TSWV.In this study,we investigated the mechanisms underlying high TSWV resistance in a specific tomato line after experimental inoculation,despite not possessing any known TSWV resistance genes.The candidate causal genes of disease resistance traits were finely mapped by constructing different genetic populations and performing bulk segregant analysis sequencing.This approach identified SlDnaJ(Solyc10g081220)as a key locus potentially regulating TSWV resistance.We determined a structural variant of SlDnaJ(designated Sldnaj)containing a 61-bp promoter sequence deletion that was specifically present in the germplasm of the susceptible M82 tomato plant lines.Sldnaj-knockout transgenic plants were significantly more resistant to TSWV than wild-type plants.Up-regulated expression of Sldnaj affected the salicylic acid/jasmonic acid signaling pathway,which induced and promoted the systemic infection of TSWV in M82 susceptible plants.In summary,this study identified a new candidate TSWV susceptibility gene with a natural deletion variation in tomato.These findings provide insights into the molecular mechanism underlying pathogen resistance while offering a target for breeding strategies of tomato with TSWV resistance. 展开更多
关键词 tomato novel resistance genes SLDNAJ tomato spotted wilt virus tswv poses promoter deletion tomato spotted wilt virus pathogen resistance breeding strategies
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T-SPOT.TB联合细胞因子检测在活动性肺结核诊断中的应用 认领 引用 被引量：1
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作者 齐亚楠 郝跃鹏 +2 位作者 张云婷 田二朋 马伟立 《中华医院感染学杂志》 CAS CSCD 北大核心 2026年第5期696-700,共5页
目的探讨结核感染T细胞斑点试验(T-SPOT.TB)联合细胞因子鉴别活动性肺结核(ATB)的诊断效能及影响因素。方法选择2019年1月—2023年10月于河北省胸科医院就诊的240例患者为研究对象,其中ATB组123例,非ATB组117例。采用AUC分析T-SPOT.TB... 目的探讨结核感染T细胞斑点试验(T-SPOT.TB)联合细胞因子鉴别活动性肺结核(ATB)的诊断效能及影响因素。方法选择2019年1月—2023年10月于河北省胸科医院就诊的240例患者为研究对象,其中ATB组123例,非ATB组117例。采用AUC分析T-SPOT.TB联合细胞因子鉴别ATB的诊断效能,Kappa一致性检验分析一致性水平,多因素logistic回归分析影响T-SPOT.TB诊断准确性因素。结果两组患者肺结核接触史、胸腔积液总蛋白、肺部细菌感染、结核菌素(PPD)试验阳性、结核分枝杆菌抗体(TB-Ab)检测阳性、胸腔积液T-SPOT.TB阳性、空洞直径、胸膜肥厚、胸膜粘连、结节性红斑和血供方面,差异均有统计学意义(P<0.05);与非ATB组相比,ATB组白细胞介素(IL)-6[(43.98±21.32)ng/L]、IL-8[(27.95±12.26)ng/L]和干扰素-γ(IFN-γ)[(40.75±19.11)ng/L]水平较高(P<0.05);ROC曲线显示,细胞因子IFN-γ、IL-6、IL-8和T-SPOT.TB斑点数联合诊断ATB患者的AUC值高于各指标单独检测(P<0.05);肺部细菌感染为影响T-SPOT.TB诊断准确性的影响因素(P=0.018,OR=5.703)。结论T-SPOT.TB联合IFN-γ、IL-6和IL-8对ATB的诊断效能良好,值得在临床推广实践。 展开更多
关键词 结核感染T细胞斑点试验 细胞因子 活动性肺结核 非活动性肺结核 准确性
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Diagnosis of focal spots at relativistic intensity utilizing coherent radiation from laser-driven flying electron sheets 认领 引用
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作者 Shirui Xu Zhuo Pan +22 位作者 Ying Gao Jiarui Zhao Shiyou Chen Zhusong Mei Xun Chen Ziyang Peng Xuan Liu Yulan Liang Tianqi Xu Tan Song Qingfan Wu Yujia Zhang Zhipeng Liu Zihao Zhang Haoran Chen Qihang Han Jundong Shen Chenghao Hua Kun Zhu Yanying Zhao Chen Lin Xueqing Yan Wenjun Ma 《Matter and Radiation at Extremes》 SCIE EI CAS CSCD 2025年第2期16-23,共8页
Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challe... Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challenges.In this work,we demonstrate for the firs time that the coherent radiation farfiel patterns from laser–foil interactions can serve as an in situ,real-time,and easy-to-implement diagnostic for an ultraintense laser focus.The laser-driven electron sheets,curved by the spatially varying laser fiel and leaving the targets at nearly the speed of light,produce doughnut-shaped patterns depending on the shapes of the focal spot and the absolute laser intensities.Assisted by particle-in-cell simulations,we can achieve measurements of the intensity and the focal spot,and provide immediate feedback to optimize the focal spots for extremely high intensity. 展开更多
关键词 diagnosis focal spot peak intensity laser foil interactions laser fi coherent radiation farfiel patterns laser driven electron sheets experimental validation laser intensity focal spot coherent radiation
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