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Super-Resolution Track-Density Imaging Reveals Fine Anatomical Features in Tree Shrew Primary Visual Cortex and Hippocampus 认领 引用 被引量：6
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作者 Jian-Kun Dai Shu-Xia Wang +2 位作者 Dai Shan Hai-Chen Niu Hao Lei 《Neuroscience Bulletin》 SCIE CAS CSCD 2018年第3期438-448,共11页
Diffusion-weighted magnetic resonance imaging（d MRI） is widely used to study white and gray matter（GM） micro-organization and structural connectivity in the brain. Super-resolution track-density imaging（TDI） is ... Diffusion-weighted magnetic resonance imaging（d MRI） is widely used to study white and gray matter（GM） micro-organization and structural connectivity in the brain. Super-resolution track-density imaging（TDI） is an image reconstruction method for d MRI data, which is capable of providing spatial resolution beyond the acquired data, as well as novel and meaningful anatomical contrast that cannot be obtained with conventional reconstruction methods. TDI has been used to reveal anatomical features in human and animal brains. In this study, we used short track TDI（st TDI）, a variation of TDI with enhanced contrast for GM structures, to reconstruct directionencoded color maps of fixed tree shrew brain. The results were compared with those obtained with the traditional diffusion tensor imaging（DTI） method. We demonstrated that fine microstructures in the tree shrew brain, such as Baillarger bands in the primary visual cortex and the longitudinal component of the mossy fibers within the hippocampal CA3 subfield, were observable with st TDI,but not with DTI reconstructions from the same d MRI data.The possible mechanisms underlying the enhanced GM contrast are discussed. 展开更多
关键词 Track-density imaging Diffusion tensor imaging Tree shrew Primary visual cortex Hippocampus
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Biomedical applications of full-spectrum photoacoustic imaging for wavelengthdependent endogenous molecules 认领 引用 被引量：1
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作者 Liwen Jiang Yuanlin Chen +5 位作者 Pengwei Han Hao Zhang Jingran Shao Zhen Tian Feng Gao Jiao Li 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2026年第4期4-21,共18页
Photoacoustic imaging has emerged as a promising technology in the life sciences,exploiting the relatively weak scattering of sound in biological tissues to overcome the penetration limits inherent in conventional opt... Photoacoustic imaging has emerged as a promising technology in the life sciences,exploiting the relatively weak scattering of sound in biological tissues to overcome the penetration limits inherent in conventional optical imaging.Relying on the photoacoustic effect,this imaging modality enables the identification of a wide range of endogenous molecules by analyzing their unique optical absorption spectra.This review summarizes characteristic molecules commonly employed in photoacoustic imaging and their corresponding biomedical applications across the full spectrum,including key bands such as X-ray,ultraviolet,visible,near-infrared,mid-infrared,terahertz,and microwave.Furthermore,the paper also outlines the main endogenous molecules used in photoacoustic imaging and their successful clinical applications,identifies current challenges in the development of full-spectrum photoacoustic imaging,and offers perspectives on future directions for technological advancement.Continued progress in photoacoustic imaging is expected to broaden its advantages,thereby facilitating advancements in biomedicine. 展开更多
关键词 Photoacoustic imaging light absorption full-spectrum imaging
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Millisecond-level electrically switchable metalens for adaptive rotational depth mapping and diffraction-limited imaging 认领 引用 被引量：1
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作者 Yeseul Kim Jihae Lee +9 位作者 Won-Sik Kim Hyeonsu Heo Dongmin Jeon Beomha Yang Xiaotong Li Harit Keawmuang Shiqi Hu Young-Ki Kim Trevon Badloe Junsuk Rho 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2026年第2期27-38,共12页
We demonstrate an electrically tunable dual-mode metalens capable of polarization-sensitive focal control,combining high-resolution imaging and depth-sensing functionalities into a single compact device.By integrating... We demonstrate an electrically tunable dual-mode metalens capable of polarization-sensitive focal control,combining high-resolution imaging and depth-sensing functionalities into a single compact device.By integrating hydrogenated amorphous silicon(a-Si:H)meta-atoms with a liquid crystal(LC)modulator,the proposed metasurface independently manipulates left-and right-circularly polarized(LCP/RCP)incident light,generating a rotating doublehelix focal distribution for LCP and an extended depth-of-focus(DOF)for RCP illumination.The meta-atoms were rigorously optimized using propagation and geometric phases,enabling precise phase control and high transmittance at a wavelength of 635 nm.Experimental characterization confirmed near-diffraction-limited lateral and axial resolutions,closely aligning with theoretical predictions.The integrated LC cell facilitates milliseconds polarizationswitching between depth-sensitive double-helix and high-resolution DOF imaging modes.We further verified depthextraction capabilities by analyzing rotation angles from dual-image focal spots under mixed-polarization illumination.Depth-resolved imaging of a rubber-tree leaf,a skeletal-muscle cross-section,and a live planarian retrieved color-coded depths,demonstrating the effectiveness on complex biological tissues.This polarization-driven,electrically tunable metalens thus provides a versatile and effective optical platform suitable for advanced applications in biomedical imaging,three-dimensional sensing,adaptive optics,and compact imaging systems. 展开更多
关键词 chiral-dependent 3D imaging retrieval chiral-dependent 3D imaging spin dependent electrically tunable metasurface
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A BODIPY-based ratiometric fluorescent probe for imaging of Zn2+ in ferroptosis 认领 引用 被引量：2
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作者 Yaheng Li Weijiang He +1 位作者 Yuncong Chen Zijian Guo 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第5期376-380,共5页
Ferroptosis is a cell death pathway that plays a crucial role in numerous biological processes.Although closely related to ferrous ion,the execution of ferroptosis was found to be impacted by zinc ion(Zn2+)in recen... Ferroptosis is a cell death pathway that plays a crucial role in numerous biological processes.Although closely related to ferrous ion,the execution of ferroptosis was found to be impacted by zinc ion(Zn2+)in recent years.However,most of the related researches focused on the effects of exogenously added Zn2+,while the fundamental understanding of endogenous Zn2+during ferroptosis still needs further exploration.Herein,a ratiometric fluorescent probe based on pyridine-substituted boron dipyrromethene(BODIPY)fluorophore(BDP-p)was designed to track the endogenous Zn2+in cells during ferroptosis process.Zn2+coordination induced an enhancement on the intramolecular charge transfer(ICT),leading to an obvious red shift from 563 nm to 594 nm.In A549 cells,we found fluorescence ratio of the probe elevated in some discrete regions during erastin induced ferroptosis,and this change followed the same trend as the reactive oxygen species(ROS)level.The results suggested that the Zn2+would be localized in some discrete areas in A549 cells during ferroptosis.This work not only provided a reliable design strategy for developing ratiometric probes of Zn2+,but also supplemented the current understanding of the non-negligible role of Zn2+in ferroptosis. 展开更多
关键词 Zn²⁺ Ferroptosis Fluorescence imaging BODIPY Ratiometric probe
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Recent advances in femtosecond direct laser writing of micro-optical imaging components 认领 引用 被引量：1
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作者 Minjing Li Wenbin Chen +7 位作者 ChunSan Deng Daqian Li Zhican Ning Huace Hu Weiming Wang Hui Gao Leimin Deng Wei Xiong 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第2期391-422,共32页
The advancement of modern optical imaging systems has generated a substantial demand for precision-engineered imaging components with complex functionalities.Despite various micro-nanofabrication techniques demonstrat... The advancement of modern optical imaging systems has generated a substantial demand for precision-engineered imaging components with complex functionalities.Despite various micro-nanofabrication techniques demonstrating significant advantages over traditional methods,critical challenges persist in achieving nanoscale resolution and freely designed intricate micro-optical structures.Femtosecond direct laser writing(FsDLW)emerges as a pivotal solution to these challenges,facilitating the fabrication of sophisticated architectures that transcend the diffraction limit through nonlinear multiphoton absorption.This technique processes exceptional capabilities,including extensive material compatibility,versatile micro-nanoscale fabrication,and true three-dimensional structuring.To date,FsDLW has been successfully employed in the manufacturing of diverse micro-optical imaging components.This review systematically elucidates the fundamental methodologies of FsDLW applicable to micro-optical device fabrication,alongside a comprehensive overview of the relevant material systems.Furthermore,recent advancements in micro-optical imaging devices and their emerging applications are critically assessed.Finally,we provide a prospective analysis of unresolved challenges and future research directions for imaging optical components. 展开更多
关键词 micro-optical imaging components FsDLW micro-nanofabrication micro-optics
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Precise and non-destructive approach for identifying the real concentration based on cured cemented paste backfill using hyperspectral imaging 认领 引用 被引量：2
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作者 Qing Na Qiusong Chen Aixiang Wu 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2026年第1期116-128,共13页
Cemented paste backfill(CPB)is a technology that achieves safe mining by filling the goaf with waste rocks,tailings,and other materials.It is an inevitable choice to deal with the development of deep and highly diffic... Cemented paste backfill(CPB)is a technology that achieves safe mining by filling the goaf with waste rocks,tailings,and other materials.It is an inevitable choice to deal with the development of deep and highly difficult mines and meet the requirements of environmental protection and safety regulations.It promotes the development of a circular economy in mines through the development of lowgrade resources and the resource utilization of waste,and extends the service life of mines.The mass concentration of solid content(abbreviated as“concentration”)is a critical parameter for CPB.However,discrepancies often arise between the on-site measurements and the pre-designed values due to factors such as groundwater inflow and segregation within the goaf,which cannot be evaluated after the solidification of CPB.This paper innovatively provides an in-situ non-destructive approach to identify the real concentration of CPB after curing for certain days using hyperspectral imaging(HSI)technology.Initially,the spectral variation patterns under different concentration conditions were investigated through hyperspectral scanning experiments on CPB samples.The results demonstrate that as the CPB concentration increases from 61wt%to 73wt%,the overall spectral reflectance gradually increases,with two distinct absorption peaks observed at 1407 and 1917 nm.Notably,the reflectance at 1407 nm exhibited a strong linear relationship with the concentration.Subsequently,the K-nearest neighbors(KNN)and support vector machine(SVM)algorithms were employed to classify and identify different concentrations.The study revealed that,with the KNN algorithm,the highest accuracy was achieved when K(number of nearest neighbors)was 1,although this resulted in overfitting.When K=3,the model displayed the optimal balance between accuracy and stability,with an accuracy of 95.03%.In the SVM algorithm,the highest accuracy of 98.24%was attained with parameters C(regularization parameter)=200 and Gamma(kernel coefficient)=10.A comparative analysis of precision,accuracy,and recall further highlighted that the SVM provided superior stability and precision for identifying CPB concentration.Thus,HSI technology offers an effective solution for the in-situ,non-destructive monitoring of CPB concentration,presenting a promising approach for optimizing and controlling CPB characteristic parameters. 展开更多
关键词 cemented paste backfill concentration hyperspectral imaging non-destructive testing
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Oxygenation-driven multimodal photoacoustic/ultrasonic imaging enhances evaluation of enthesitis disease activity in psoriatic arthritis 认领 引用 被引量：1
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作者 Rui Zhang Fan Yang +8 位作者 Chenyang Zhao Ming Wang Yan Zhang Fang Yang Lei Zhu Jianchu Li Yuxin Jiang Xiaomei Leng Meng Yang 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2026年第1期126-138,共13页
Conventional ultrasound(US)evaluation of enthesitis in psoriatic arthritis(PsA)is limited by its inability to quantify metabolic alterations such as hypoxia,a key driver of disease activity.We introduce an oxygenation... Conventional ultrasound(US)evaluation of enthesitis in psoriatic arthritis(PsA)is limited by its inability to quantify metabolic alterations such as hypoxia,a key driver of disease activity.We introduce an oxygenation-integrated multimodal photoacoustic/ultrasound(PA/US)imaging framework designed to quantify entheseal oxygen saturation(SO2)for assessing entheseal disease activity in PsA.In this cross-sectional study,25 PsA patients underwent bilateral PA/US imaging of 12 entheses,where ultrasound lesions were scored using the Outcome Measures in Rheumatology scoring system,and PA-derived SO2 levels,quantified via dual-wavelength PA imaging,were classified into hyperoxia or hypoxia groups using k-means clustering.This approach provides metabolic insights complementary to conventional ultrasonic assessment.A composite score integrating hypoxia with US parameters was validated against clinical disease activity indices(Disease Activity Score 28-C-reactive protein,DAS28-CRP;Disease Activity Index for Psoriatic Arthritis,DAPSA).Among 300 entheses,103(34.3%)exhibited PA positivity,with 40(38.8%)classified as hypoxia.Hypoxia scores independently predicted DAS28-CRP(β=0.618,p=0.001)and DAPSA(β=0.612,p<0:001).The hypoxia-optimized PAUS score demonstrated superior correlation with disease activity indices compared to conventional US(DAS28-CRP:r=0.615,p=0.001 versus r=0.474,p=0.017;DAPSA:r=0.743,p<0:001 versus r=0.567,p=0.003),alongside superior diagnostic accuracy for minimal disease activity(area under the curve,AUC 0.776 versus 0.614,p=0.008)and low disease activity(AUC 0.853 versus 0.772,p=0.009).This multimodal scoring system enhances the stratification of PsA disease activity by providing unique metabolic insights,offering a potential tool for therapeutic monitoring and guiding treat-to-target strategies. 展开更多
关键词 Photoacoustic imaging oxygen saturation enthesis disease activity evaluation
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Laser-optical-field-modulation fabricating large-aperture dual-band antireflection windows for MWIR and LWIR imaging 认领 引用 被引量：2
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作者 Yulong Ding Cong Wang +8 位作者 Xianshi Jia Linpeng Liu Zheng Gao Xiang Jiang Shiyu Wang Dejin Yan Nai Lin Zhou Li Ji’an Duan 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第2期560-574,共15页
Dual-band antireflection(DBAR)windows based on surface microstructures offer a promising solution for mid-wave infrared(MWIR)and long-wave infrared(LWIR)co-aperture composite imaging.However,micro-nano manufacturing t... Dual-band antireflection(DBAR)windows based on surface microstructures offer a promising solution for mid-wave infrared(MWIR)and long-wave infrared(LWIR)co-aperture composite imaging.However,micro-nano manufacturing technology faces significant challenges in efficiently producing highly uniform microstructures with characteristic dimensions of∼1μm across hundreds of millimeters.Here,we report a laser optical field modulation(LOFM)technology for the rapid manufacture of ultra-large-scale arrays of antireflection microholes(ARMHs)on large-aperture and non-perfectly planar windows.LOFM technology,which modulates laser pulses in both temporal and spatial domains,enhances ARMH aspect ratios from 0.1 to 0.8 without reducing manufacturing time,and maintains processing accuracy even with laser focus shifts,thereby addressing inconsistencies in large-area processing.As a proof of concept,approximately 7 billion ARMHs are fabricated on a 100-mm-diameter zinc sulfide(ZnS)window at a rate of 20000 holes per second using LOFM technology assisted by machine learning.The fabricated DBAR ZnS window exhibits ultra-broadband(3.5−14μm),high transmittance(91.1%),wide-angle transmission,wear-resistant,and self-cleaning,making it suitable for environments with multiple interference factors.Dual-band imaging applications demonstrate the significant advantages of DBAR windows in target recognition,multi-scenario robustness,and information acquisition. 展开更多
关键词 laser optical field modulation large-aperture window non-perfectly planar antireflection microstructure dual-band infrared imaging
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In‑Operando X‑Ray Imaging for Sobering Examination of Aqueous Zinc Metal Batteries 认领 引用 被引量：1
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作者 Yuhang Dai Hongzhen He +4 位作者 Mengzheng Ouyang Jianuo Chen Jie Lin Haobo Dong Guanjie He 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第3期330-337,共8页
Aqueous zinc metal batteries(AZMBs)face significant challenges in achieving reversibility and cycling stability,primarily due to hydrogen evolution reactions(HER)and zinc dendrite growth.In this study,by employing car... Aqueous zinc metal batteries(AZMBs)face significant challenges in achieving reversibility and cycling stability,primarily due to hydrogen evolution reactions(HER)and zinc dendrite growth.In this study,by employing carefully designed cells that approximate the structural characteristics of practical batteries,we revisit this widely held view through in-operando X-ray radiography to examine zinc dendrite formation and HER under nearpractical operating conditions.While conventional understanding emphasizes the severity of these processes,our findings suggest that zinc dendrites and HER are noticeably less pronounced in dense,real-operation configurations compared to modified cells,possibly due to a more uniform electric field and the suppression of triple-phase boundaries.This study indicates that other components,such as degradation at the cathode current collector interface and configuration mismatches within the full cell,may also represent important barriers to the practical application of AZMBs,particularly during the early stages of electrodeposition. 展开更多
关键词 Aqueous Zn metal batteries X-ray imaging In situ characterization Degradation mechanism
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High-efficiency infrared upconversion imaging with nonlinear silicon metasurfaces empowered by quasi-bound states in the continuum 认领 引用 被引量：1
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作者 Tingting Liu Jumin Qiu +6 位作者 Meibao Qin Xu Tu Huifu Qiu Feng Wu Tianbao Yu Qiegen Liu Shuyuan Xiao 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2026年第4期75-85,共11页
Infrared imaging is indispensable for its ability to penetrate obscurants and visualize thermal signatures,yet its practical use is hindered by the intrinsic limitations of conventional detectors.Nonlinear upconversio... Infrared imaging is indispensable for its ability to penetrate obscurants and visualize thermal signatures,yet its practical use is hindered by the intrinsic limitations of conventional detectors.Nonlinear upconversion,which converts infrared light into the visible band,offers a promising pathway to address these challenges.Here,we demonstrate high-efficiency infrared upconversion imaging using nonlinear silicon metasurfaces.By strategically breaking in-plane symmetry,the metasurface supports a high-Q quasi-bound states in the continuum resonance,leading to strongly enhanced third-harmonic generation(THG)with a conversion efficiency of 3×10-5 at a pump intensity of 10 GW/cm2.Through this THG process,the metasurface enables high-fidelity upconversion of arbitrary infrared images into the visible range,achieving a spatial resolution of~6μm as verified using a resolution target and various customized patterns.This work establishes a robust platform for efficient nonlinear conversion and imaging,highlighting the potential of CMOS-compatible silicon metasurfaces for high-performance infrared sensing applications with reduced system complexity. 展开更多
关键词 infrared upconversion imaging nonlinear metasurfaces bound states in the continuum third-harmonic generation
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Development of a polarized-neutron imaging technique at the China Advanced Research Reactor 认领 引用
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作者 Zheng‑Yao Li Tian‑Hao Wang +13 位作者 Si‑Qin Meng Jun‑Pei Zhang Li‑Jie Hao Jian Tang Tian‑Yun Wang Shi‑Hao Ruan Hong‑Liang Wang Mei‑Mei Wu Long Tian Bin Wang Ahmed Salman Lin‑Feng He Xin Tong Dong‑Feng Chen 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2026年第8期297-307,共11页
In contrast to conventional neutron imaging by measuring the attenuation contrast,polarized-neutron imaging(PNI)has proved to be a powerful tool for investigating the spatial distribution of magnetic fields inside and... In contrast to conventional neutron imaging by measuring the attenuation contrast,polarized-neutron imaging(PNI)has proved to be a powerful tool for investigating the spatial distribution of magnetic fields inside and around bulk samples owing to the intrinsic magnetic moment of neutrons.This technique benefits from the measurement of the cumulative precession of the neutron polarization passing through a magnetic field.We report the recent development of the PNI capability at the China Advanced Research Reactor(CARR),where two neutron imaging instruments(thermal and cold)have been established.To further develop and realize the PNI technique,a PNI facility consisting of a double-crystal pyrolytic graphite monochromator,supermirror polarizer with three parallel V-shaped cavities and an in situ optically pumped 3He neutron spin filter as a neutron spin analyzer was successfully developed and tested based on an established cold neutron imaging instrument.This setup will be beneficial for enhancing neutron imaging and neutron optics in CARR in the future. 展开更多
关键词 Neutron radiography Polarized-neutron imaging Magnetic imaging Magnetic field Polarizing supermirror
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Multifunctional FA-PDA@ICG-Bi2Se3 nanoplatform for targeted NIR and X-ray dual-modal imaging and photothermal therapy of cervical cancer 认领 引用
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作者 Zhong Du Li-Jun Zhu +9 位作者 Jia-Bao Xiong Yu-Xiang Gao Ya-Qi Cui Maierhaba Aili Chen-Yang Chu Chi Zhang Gao-Fei Huang Xue-Liang Zhang Nuernisha Alifu Biao Dong 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第4期716-720,共5页
Cervical cancer remains a leading cause of cancer-related mortality in women,underscoring the urgent need for advanced diagnostic and therapeutic strategies.Current imaging techniques face significant limitations,incl... Cervical cancer remains a leading cause of cancer-related mortality in women,underscoring the urgent need for advanced diagnostic and therapeutic strategies.Current imaging techniques face significant limitations,including radiation exposure,high costs,and inadequate sensitivity for detecting early metastases,particularly in imaging and diagnosing tumor metastatic lesions.To overcome these challenges,we developed a multimodal imaging strategy that combined near-infrared fluorescence(NIRF,750-1700 nm)imaging with X-ray imaging,with assistance of innovative nanomaterial to achieve precise tumor targeting and comprehensive diagnostic.Specifically,we synthesized a folate acid-functionalized polydopamine-modified ICG-Bi2Se3 nanocomposite(FA-PDA@ICG-Bi2Se3,FPBI),which integrated the complementary advantages of NIRF,X-ray,and computerized tomography imaging.The FPBI nanocomposite leveraged the targeting capability of folate acid for specific identification of cervical cancer lesions and metastatic lymph node.Furthermore,it demonstrated robust photothermal therapeutic efficacy under near-infrared(808 nm)excitation,achieving significant tumor ablation effects.This work provides an innovative nanoplatform based strategy for multimodal imaging,precise diagnosis,and targeted therapy of cervical cancer,paving the way for improved detection and management of metastatic lesions. 展开更多
关键词 NIR fluorescent imaging Active targeting Dual-modal imaging Metastasis Photothermal therapy
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Corrigendum to “Enhancing the stability of 68Ga-labeled RNA aptamers for pancreatic β-cell and insulinoma imaging through nucleoside modifications” [Chinese Chemical Letters 36 (2025) 110804] 认领 引用
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作者 Zhe Li Haozhi Lei +3 位作者 Zhiqiang Ren Cheng Wang Qian Xia Weihong Tan 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第5期800-802,共3页
The authors regret that during reviewing the published data,we identified an inadvertent image misplacement in Fig.2.Fig.2b presents the serum stability electrophoresis result of the RNA aptamer 1-717,whereas Fig.2d s... The authors regret that during reviewing the published data,we identified an inadvertent image misplacement in Fig.2.Fig.2b presents the serum stability electrophoresis result of the RNA aptamer 1-717,whereas Fig.2d shows the corresponding result for the RNA aptamer m12-3773.Because the two aptamers have similar lengths(1-717 contains 40 bases and m12-3773 contains 44 bases)and exhibited highly comparable serum stability profiles,resulting in the erroneous reuse of the Fig.2d image in Fig.2b. 展开更多
关键词 RNA aptamers nucleoside modifications pancreatic cell imaging serum stability profilesresulting image misplacement insulinoma imaging serum stability electrophoresis serum stability
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A radiomics approach for predicting gait freezing in Parkinson's disease based on resting-state functional magnetic resonance imaging indices:A cross-sectional study 认领 引用 被引量：3
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作者 Miaoran Guo Hu Liu +6 位作者 Long Gao Hongmei Yu Yan Ren Yingmei Li Huaguang Yang Chenghao Cao Guoguang Fan 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第4期1621-1627,共7页
Freezing of gait is a significant and debilitating motor symptom often observed in individuals with Parkinson's disease.Resting-state functional magnetic resonance imaging,along with its multi-level feature indice... Freezing of gait is a significant and debilitating motor symptom often observed in individuals with Parkinson's disease.Resting-state functional magnetic resonance imaging,along with its multi-level feature indices,has provided a fresh perspective and valuable insight into the study of freezing of gait in Parkinson's disease.It has been revealed that Parkinson's disease is accompanied by widespread irregularities in inherent brain network activity.However,the effective integration of the multi-level indices of resting-state functional magnetic resonance imaging into clinical settings for the diagnosis of freezing of gait in Parkinson's disease remains a challenge.Although previous studies have demonstrated that radiomics can extract optimal features as biomarkers to identify or predict diseases,a knowledge gap still exists in the field of freezing of gait in Parkinson's disease.This cross-sectional study aimed to evaluate the ability of radiomics features based on multi-level indices of resting-state functional magnetic resonance imaging,along with clinical features,to distinguish between Parkinson's disease patients with and without freezing of gait.We recruited 28 patients with Parkinson's disease who had freezing of gait(15 men and 13 women,average age 63 years)and 30 patients with Parkinson's disease who had no freezing of gait(16 men and 14 women,average age 64 years).Magnetic resonance imaging scans were obtained using a 3.0T scanner to extract the mean amplitude of low-frequency fluctuations,mean regional homogeneity,and degree centrality.Neurological and clinical characteristics were also evaluated.We used the least absolute shrinkage and selection operator algorithm to extract features and established feedforward neural network models based solely on resting-state functional magnetic resonance imaging indicators.We then performed predictive analysis of three distinct groups based on resting-state functional magnetic resonance imaging indicators indicators combined with clinical features.Subsequently,we conducted 100 additional five-fold cross-validations to determine the most effective model for each classification task and evaluated the performance of the model using the area under the receiver operating characteristic curve.The results showed that when differentiating patients with Parkinson's disease who had freezing of gait from those who did not have freezing of gait,or from healthy controls,the models using only the mean regional homogeneity values achieved the highest area under the receiver operating characteristic curve values of 0.750(with an accuracy of 70.9%)and 0.759(with an accuracy of 65.3%),respectively.When classifying patients with Parkinson's disease who had freezing of gait from those who had no freezing of gait,the model using the mean amplitude of low-frequency fluctuation values combined with two clinical features achieved the highest area under the receiver operating characteristic curve of 0.847(with an accuracy of 74.3%).The most significant features for patients with Parkinson's disease who had freezing of gait were amplitude of low-frequency fluctuation alterations in the left parahippocampal gyrus and two clinical characteristics:Montreal Cognitive Assessment and Hamilton Depression Scale scores.Our findings suggest that radiomics features derived from resting-state functional magnetic resonance imaging indices and clinical information can serve as valuable indices for the identification of freezing of gait in Parkinson's disease. 展开更多
关键词 amplitude of low-frequency fluctuation degree centrality feedforward neural network freezing of gait machine learning parahippocampal gyrus Parkinson's disease receiver operating characteristic regional homogeneity resting-state functional magnetic resonance imaging
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In vivo second near-infrared fluorescence and ratiometric photoacoustic dual-modality imaging of glutathione 认领 引用
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作者 Yu Zhang Shan Lei +7 位作者 Yuantao Pan Chao Zhao Qiang Liu Yumeng Wu Yurong Liu Meng Li Peng Huang Jing Lin 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第2期303-307,共5页
The level of glutathione(GSH)is significantly associated with numerous pathological processes,thus,real-time detection of the GSH level is of significance for early diagnosis of GSH-related diseases.Herein,we develope... The level of glutathione(GSH)is significantly associated with numerous pathological processes,thus,real-time detection of the GSH level is of significance for early diagnosis of GSH-related diseases.Herein,we developed in vivo second near-infrared(NIR-II)window fluorescence(FL)and ratiometric photoacoustic(RPA)dual-modality imaging of GSH using a GSH-activatable probe(LET-14).LET-14 was synthesized based on a rhodamine hybrid xanthene skeleton with a FL shielding 2,4-dinitrobenzene sulfonyl group that can be specifically cleaved by GSH,thus resulting in a markedly bathochromic-shift absorption,a 6.5-fold increase in NIR-II FL intensity(FL920)and a 13-fold increase in RPA signal(PA880/PA705)in vitro.Intriguingly,LET-14 exhibits good selectivity and sensitivity for NIR-II FL and RPA dual-modality imaging of GSH in 4T1 tumor-bearing mouse model.Our findings develop an in vivo detection tool of GSH,which has great potential in the field of cancer diagnosis. 展开更多
关键词 Glutathione In vivo Second near-infrared dye Fluorescence imaging Ratiometric photoacoustic imaging
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3D nanoscale fabrication and imaging:a multimodal approach for in situ and super-resolution characterization 认领 引用
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作者 Qiulan Liu Jisen Wen +11 位作者 Liang Xu Zhenyao Yang Chun Cao Shangting You Gangyao Zhan Yiwei Qiu Wenjie Liu Xiaobing Wang Cuifang Kuang Dazhao Zhu Shih-Chi Chen Xu Liu 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第2期639-652,共14页
The synergistic innovation of nanoscale optical fabrication and characterization technologies holds the key to overcoming three-dimensional(3D)precision manufacturing bottlenecks.This study reports the novel self-repo... The synergistic innovation of nanoscale optical fabrication and characterization technologies holds the key to overcoming three-dimensional(3D)precision manufacturing bottlenecks.This study reports the novel self-reporting functionality of 7-diethylamino-3-thenoylcoumarin(DETC)in photoresist,which serves as both a super-resolution photoinitiator and an intrinsic fluorophore with stimulated emission depletion(STED)behavior and polymerization-dependent lifetime characteristics.Through the development of an integrated system combining STED-inspired periphery photoinhibition(PPI)printing with dual-mode imaging,we achieve simultaneous in situ characterization and super-resolution quality verification.Specifically,PPI imaging demonstrates 50-nm lateral resolution for 40-nm printed lines and resolves 200-nm axial gaps when characterizing developed structures.Furthermore,in situ fluorescence lifetime imaging(FLIM)achieves nanometer-level resolution,comparable to confocal microscopy,by utilizing DETC’s lifetime shift to characterize undeveloped structures.This synergy imaging approach resolves the trade-off between resolution and non-destructive detection,while establishing a new paradigm for closed-loop optimization of complex 3D nanodevices,with profound implications for nanophotonics,precision biosensing,and ultrahigh-density optical storage. 展开更多
关键词 super resolution laser direct writing microscopy peripheral photoinhibition in situ imaging fluorescence lifetime imaging
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Effect of measurement reduction on synthetic aperture x-ray ghost imaging 认领 引用
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作者 Haipeng Zhang Jie Tang +4 位作者 Nixi Zhao Changzhe Zhao Jianwen Wu Zhongliang Li Tiqiao Xiao 《Chinese Physics B》 SCIE EI CAS CSCD 2026年第1期457-465,共9页
The unique advantage of x-ray ghost imaging(XGI)is its potential in low dose radiology.One of the practical ways to reduce the radiation exposure is to reduce the measurements while remaining sufficient image quality.... The unique advantage of x-ray ghost imaging(XGI)is its potential in low dose radiology.One of the practical ways to reduce the radiation exposure is to reduce the measurements while remaining sufficient image quality.Synthetic aperture x-ray ghost imaging(SAXGI)is invented to achieve megapixel XGI with limited measurements,which is expected to implement XGI simultaneously with large field of view and low radiation exposure.In this paper,we experimentally investigate the effect of measurements reduction on the spatial resolution and image quality of SAXGI with standard sample and biomedical specimen.The results with a resolution chart demonstrated that at 360 measurements,SAXGI successfully retrieved the sample image of 1960×1960 pixels with spatial resolution of 4μm.With measurement reduction,the spatial resolution deteriorates but the sparser structures are still discernable.Even with measurements reduced to 10,a spatial resolution of 10μm can still be achieved by SAXGI.A biomedical sample of a fish specimen is employed to evaluate the method and the fish image of 2000×1000 pixels with an SSIM of 0.962 is reconstructed by SAXGI with 770measurements,corresponding to an accumulative exposure reduction of more than 2 times.With the measurements reduced to 10 which corresponds to 1/160 of the accumulative radiation exposure for conventional radiology,bulky structure like the fish skeleton can still be definitely discerned and the SSIM for the reconstructed image still retained 0.9179.Results of this paper demonstrate that measurements reduction is practicable for the radiation exposure reduction of the sample,which implicates that SAXGI with limited measurements is an efficient solution for low dose radiology. 展开更多
关键词 x-ray ghost imaging synthetic aperture x-ray imaging low dose radiology compressed sensing algorithm
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From pixels to prognosis:A comprehensive evidence synthesis on pre-retrieval imaging in deceased and living liver donors 认领 引用
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作者 Andrea Peloso Daniel Pietrasz +7 位作者 Charles-Henry Wassmer Edoardo Maria Muttillo Beat Moeckli Rohan Kumar Francois Cauchy Alexis Ricoeur Philippe Compagnon Christian Toso 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2026年第3期243-253,共11页
Pre-retrieval imaging has a pivotal role in liver transplantation,donor selection,operative planning,and the prevention of postoperative complications.Conventional modalities(ultrasound,computed tomography,and magneti... Pre-retrieval imaging has a pivotal role in liver transplantation,donor selection,operative planning,and the prevention of postoperative complications.Conventional modalities(ultrasound,computed tomography,and magnetic resonance imaging)remain the foundation of liver graft evaluation.However,their diagnostic performance remains constrained by physiological factors,operator dependence and interinstitutional variability and thus,intraoperative and pre-retrieval biopsies are still important.Emerging innovations in radiomics and artificial intelligence are redefining the landscape of graft evaluation,offering unprecedented opportunities for non-invasive characterization,heightened diagnostic precision,and establishment of self-sustaining feedback loops to advance clinical practice.This work provides a systematic synthesis of current radiological evidence on steatosis detection,appraisal of vascular anomalies in deceased donors,and delineation of biliary variants and volumetry in living donors.While these innovations hold considerable promises,progresses are still limited by methodological heterogeneity,modest cohort sizes,and absence of robust multicenter validation.Universally accepted imaging protocols and advanced analytic tools with intraoperative and histological reference standards will be pivotal to realizing their transformative potential.Within the framework of a learning health system,imaging could move beyond a diagnostic tool to become a driver of precision liver graft selection,reducing reliance on invasive biopsy and enhancing safety for both donors and recipients. 展开更多
关键词 Liver transplantation Preoperative imaging Radiomics Radiological liver graft assessment Computed tomography Ultrasound Magnetic resonance imaging
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Magnetic resonance imaging tracing of superparamagnetic iron oxide nanoparticle-labeled mesenchymal stromal cells for repairing spinal cord injury 认领 引用 被引量：1
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作者 Xiaoli Mai Yuanyuan Xie +12 位作者 Zhichong Wu Junting Zou Jiacheng Du Yunpeng Shen Hao Liu Bo Chen Mengxia Zhu Jiong Shi Yang Chen Bing Zhang Zezhang Zhu Bin Wang Ning Gu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期2031-2039,共9页
Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in hu... Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury. 展开更多
关键词 acute spinal cord injury diffusion tensor imaging dynamic migration mesenchymal stromal cells neural function neuronal regeneration quantitative susceptibility mapping repairability ruicun superparamagnetic iron oxide nanoparticle
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Breaking the speed-resolution trade-off in 3.3-km non-line-of-sight imaging using scanning-free laser reflective tomography 认领 引用
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作者 Zewei Wang Xiaoyin Li +6 位作者 Yinghui Guo Hengshuo Guo Peng Yang Fei Zhang Mingbo Pu Mingfeng Xu Xiangang Luo 《Opto-Electronic Science》 CAS 2026年第6期12-21,共10页
Non-line-of-sight(NLOS)imaging,which allows the recovery of hidden scenes outside the direct view,holds immense potential across numerous fields.However,conventional scanning-based NLOS imaging systems,face a fundamen... Non-line-of-sight(NLOS)imaging,which allows the recovery of hidden scenes outside the direct view,holds immense potential across numerous fields.However,conventional scanning-based NLOS imaging systems,face a fundamental trade-off between imaging speed and resolution due to their reliance on scanning relay surfaces,where dense sampling prolongs measurement.Here,we introduce a scanning-free NLOS imaging technique that adapts laser reflective tomography(LRT)to reconstruct hidden objects by exploiting the diffuse relay surface as a natural beam expander.Our method requires only single-point detection of third-bounce photons,effectively breaking through the resolution and speed limitations imposed by scanning.Compared with scanning-based approaches,it delivers a twofold enhancement in spatial resolution and a 91-fold improvement in imaging speed.Furthermore,we extend the advantages of this method to long-range experiments,demonstrating NLOS imaging over 3.3 km with a resolution of 3 cm in 3 minutes,establishing new benchmarks in imaging range,resolution,and speed for NLOS imaging. 展开更多
关键词 non-line-of-sight imaging laser reflective tomography computational imaging
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