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Amino Acid Transporter OsAAP18 Modulates Nitrogen Allocation to Boost Yield and Grain Quality in Rice 认领 引用
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作者 HE Chongchong YANG Xiaochuan +6 位作者 ZHANG Jie WU Wenhao WANG Chuanbo CHEN Wenbo WU Bowen HUANG Weiting FANG Zhongming 《Rice science》 SCIE CAS CSCD 2026年第2期151-154,I0028-I0040,共4页
Synergistically improving the yield and grain quality of rice remains a major breeding challenge.Amino acid transporters play key roles in regulating plant growth and development,but their mechanisms in synergisticall... Synergistically improving the yield and grain quality of rice remains a major breeding challenge.Amino acid transporters play key roles in regulating plant growth and development,but their mechanisms in synergistically regulating yield and quality remain unclear.Here,we report that the plasma membrane-localized transporter OsAAP18,which is more highly expressed in indica than japonica rice,positively correlates with tiller number and yield but negatively with grain width.OsAAP18 transports eight amino acids,including asparagine(Asn),proline(Pro),leucine(Leu),and valine(Val).Its overexpression increases yield through enhanced tillering and grain number per panicle while also improving rice processing and cooking quality.Transcriptome analysis showed that OsAAP18 coordinates grain development and quality formation by regulating the expression of key genes involved in starch and sucrose metabolism,nitrogen metabolism,and plant hormone signaling pathways.These findings establish OsAAP18 as a dual-function regulator that synergistically enhances yield and quality,offering a promising target for rice breeding. 展开更多
关键词 plasma membrane localized transporter acid transporters nitrogen allocation transports eight amino acidsi OSAAP yield grain quality rice breeding
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Impairment of hippocampal long-term potentiation by soluble amyloid-βoligomers is mediated by glutamate transporter 1 expressed in neurons 认领 引用
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作者 Shaomin Li Jianlin Wang +5 位作者 Qianqin Guo Yunxin Bai Wen Liu Kevin JHodgetts Paul ARosenberg Dennis J.Selkoe 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3171-3177,共7页
In Alzheimer’s disease,perturbations of glutamate neurotransmission lead to synaptic dysfunction and synapse loss.Several studies have used glutamate transport inhibitors to demonstrate that soluble oligomers of amyl... In Alzheimer’s disease,perturbations of glutamate neurotransmission lead to synaptic dysfunction and synapse loss.Several studies have used glutamate transport inhibitors to demonstrate that soluble oligomers of amyloid-βinduce synaptic dysfunction by interrupting glutamate uptake mediated by glutamate transporter 1,the major glutamate transporter in the brain.The cellular targets of the synaptic effects of soluble amyloid-βoligomers,including the nature of any interaction with glutamate transporter 1,remain ill-defined.We have generated a conditional glutamate transporter 1 knockout mouse to investigate cell-type specific functions of glutamate transporter 1.Field excitatory postsynaptic potentials were examined in the CA1 region of mouse hippocampal slices.We confirmed that hippocampal long-term potentiation impairment is induced by both soluble amyloid-β oligomers and glutamate uptake inhibitors.Amyloid-βoligomers,including those isolated directly from the cortex of patients with Alzheimer’s disease,failed to inhibit hippocampal long-term potentiation in neuronal glutamate transporter 1 but not astrocytic glutamate transporter 1 knockout mice.The masking or occlusion of the effect of soluble amyloid-β oligomers by knockout of glutamate transporter 1 in neurons suggests that the metabolic or signaling consequences of knockout of glutamate transporter 1 in neurons and amyloid-βoligomer inhibition of synaptic plasticity show epistasis and thus share a similar molecular pathway.To extend these observations,we tested the effects of other types of manipulation of glutamate homeostasis on synaptic plasticity and the pathophysiology of soluble amyloid-β oligomers.Ceftriaxone,which upregulates glutamate transporter 1 levels,among other effects,prevented the impairment of long-term potentiation by soluble amyloid-β oligomers.Collectively,our findings suggest that the effects of amyloid-βon synaptic function are highly dependent on glutamate reuptake homeostasis and that the disruption of synaptic function by soluble amyloid-β oligomers is mediated by pathways linked to neuronal,not astrocytic,glutamate transporter 1.The findings of this study highlight the translational potential of targeting neuronal glutamate transporter 1 to counteract amyloid-β-induced synaptic dysfunction in Alzheimer’s disease.By showing that glutamate transporter 1 upregulation(e.g.,via ceftriaxone)can prevent amyloid-β-related impairments,this research supports developing therapies aimed at modulating glutamate homeostasis to preserve synaptic function and combat cognitive decline in patients with Alzheimer’s disease. 展开更多
关键词 Alzheimer’s disease ceftriaxone glutamate transporter 1 hippocampal synaptic plasticity long-term potentiation mitochondria presynaptic soluble Aβoligomers
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A boron transporter,BnaC3.BOR1,is critical for boron regulation in roots,stem integrity,and floral organs in Brassica napus L. 认领 引用
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作者 Ling Liu Dan Zou +4 位作者 Yifan Zhang Haoran Xu Fangsen Xu Xianjie Duan Sheliang Wang 《The Crop Journal》 SCIE CSCD 2026年第4期1230-1241,共12页
Brassica napus L.is an allotetraploid plant that contains numerous boron(B)transporter genes,the functions of which are largely unknown.Here,we identified BnaC3.BOR1,a gene expressed in various tissues,including roots... Brassica napus L.is an allotetraploid plant that contains numerous boron(B)transporter genes,the functions of which are largely unknown.Here,we identified BnaC3.BOR1,a gene expressed in various tissues,including roots,stems,leaves,and floral organs.In yeast,BnaC3.BOR1 expression significantly reduces cellular B concentration.When grown in B-poor conditions,BnaC3.BOR1 mutation significantly lowered B concentrations in the xylem sap.BnaC3.BOR1 mutants exhibited stunted growth,including shorter roots,reduced shoot biomass,and leaf curling,compared to wild-type B.napus.In low-B soil,loss of BnaC3.BOR1function resulted in shorter plant height and abnormal floral organ development with lower B levels,which ultimately reduced yield at the reproductive stage.Furthermore,BnaC3.BOR1 is expressed in multiple tissues,with specific expression in the regions below the nodes of stems.Mutants grown in B-poor soil exhibited stem cracking,and the B concentration in these cracks was lower than in wild-type plants.These findings indicate that BnaC3.BOR1 possesses the same conserved role in roots and flowers as previously discovered BOR1s,while having a distinct,specific role in stems.Our study provides a clear example of the functional diversification of B transporter homologous genes. 展开更多
关键词 Brassica napus L. Boron homeostasis BnaC3.BOR1 Boron transporter Function diversification
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NRAMPs:Versatile Transporters Involved in Metal Ion Homeostasis and Their Applications in Rice Breeding 认领 引用
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作者 HUANG Qina WU Lijuan +4 位作者 JIANG Hongrui HE Yan LIU Song YANG Changdeng LIANG Yan 《Rice science》 SCIE CAS CSCD 2026年第1期39-58,I0046,共20页
The NRAMP(natural resistance-associated macrophage protein)family plays a pivotal role in metal ion transport,regulating both essential micronutrient uptake and toxic heavy metal accumulation in plants.In rice(Oryza s... The NRAMP(natural resistance-associated macrophage protein)family plays a pivotal role in metal ion transport,regulating both essential micronutrient uptake and toxic heavy metal accumulation in plants.In rice(Oryza sativa),OsNRAMP transporters critically influence metal homeostasis,stress adaptation,and grain safety.Among them,OsNRAMP5 serves as a major entry point for cadmium(Cd)and manganese(Mn)uptake,making it a prime target for low-Cd rice breeding.However,knockout of OsNRAMP5 leads to severe Mn deficiency,highlighting the need for precise genetic modifications(e.g.,OsNRAMP5-Q337K),which reduce Cd accumulation while maintaining Mn nutrition.Additionally,OsNRAMP1 and OsNRAMP2 contribute to Cd translocation and plant immunity,whereas OsNRAMP3/4/6/7 participate in Mn,iron,and zinc distribution and stress responses.This review systematically summarizes the structural,functional,and regulatory mechanisms of OsNRAMPs,emphasizing their roles in metal transport,pathogen resistance,and abiotic stress adaptation.Furthermore,we discuss strategies for developing low-Cd rice varieties,including QTL-based breeding,CRISPR/Cas9-mediated gene editing,and multi-gene stacking approaches.Finally,we outline future research directions,such as structural engineering of metal-binding sites and field validation of engineered rice lines,to ensure sustainable rice production in heavy metal-contaminated soils. 展开更多
关键词 NRAMP transporter metal homeostasis cadmium regulatory network low-cadmium rice breeding
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Layered nitrogen application increases post-anthesis nutrient accumulation and grain yield of wheat by coordinating root morphology and nutrient transporter gene expression 认领 引用
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作者 Yang Zhou Yongqiao Zhang +5 位作者 Xinhua Lyu Jiaming Cui Shuang Li Pengjia Wu Xiang Lin Dong Wang 《The Crop Journal》 SCIE CSCD 2026年第3期997-1007,共11页
Layered nitrogen(N)application to wheat is intended to avert nutrient retention in the topsoil,which limits deep root development and grain yield.In a two-year field experiment on the Loess Plateau comparing two N tre... Layered nitrogen(N)application to wheat is intended to avert nutrient retention in the topsoil,which limits deep root development and grain yield.In a two-year field experiment on the Loess Plateau comparing two N treatments:240 kg N ha-1applied at the 8-cm soil depth or in a 1:2:1 ratio to the 8-,16-,and 24-cm soil layers,the layered treatment increased grain yield,post-anthesis N accumulation,phosphorus(P)accumulation,root biomass,and soil organic carbon and available P in the 8-24 cm layers.It also upregulated N and P transporter genes in roots across different soil layers.Layered N application optimized the vertical nutrient distribution in the wheat root zone,induced adaptive root architectural development,and activated the transcriptional regulatory network of nutrient uptake,which peomoted post-anthesis nutrient assimilation and ultimately improving grain yield. 展开更多
关键词 Layered fertilization Root morphology Post-anthesis nutrient accumulation Root N and P transporter genes Wheat grain yield
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Molecular and Functional Insights into Sugar Transporters in Rice 认领 引用
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作者 Kieu Anh Thi PHAN Juho LEE +1 位作者 Cong Danh NGUYEN Sang-Kyu LEE 《Rice science》 SCIE CAS CSCD 2026年第3期309-326,I0224-I0225,共18页
Sugars are the main sources of energy and carbon for plants,making them crucial for various aspects of plant growth and development.Three prominent families of sugar transporters have been extensively researched:sucro... Sugars are the main sources of energy and carbon for plants,making them crucial for various aspects of plant growth and development.Three prominent families of sugar transporters have been extensively researched:sucrose transporter,monosaccharide transporter,and sugars will eventually be exported transporter.The primary function of sugar transporters is to facilitate the movement of saccharide molecules,particularly sucrose and glucose,from cell to cell or from source tissues,such as leaves,to sink tissues like roots and developing seeds.Beyond mere transport,sugar transporters are integral to several biological and physiological processes in the plant.They are involved in phloem loading,which is critical for nutrient distribution throughout the plant,contribute to overall plant growth and development,and are essential in response to biotic(e.g.,pathogen attack)and abiotic(e.g.,drought or salinity)stresses.In this review,we provide a comprehensive summary and update on the functions of these sugar transporters,specifically in rice,and highlight the potential applications of gene editing technologies,which could be harnessed to enhance rice traits and improve yield. 展开更多
关键词 sugar transporter plant growth and development biotic stress abiotic stress genome editing rice
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Spectrum and functions of ion channels and transporters in osteoclasts 认领 引用
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作者 Hongyu Chen Yanli Zhang +3 位作者 Yulong Zhu Xiang Xiao Shanshan Huang Xiaohong Duan 《Bone Research》 SCIE CAS CSCD 2026年第2期447-477,共31页
Osteoclasts are essential for bone resorption and interact with osteoblasts during bone remodeling.Ion channels and transporters located in the ruffled border or intracellular vesicles coordinate the transport of vari... Osteoclasts are essential for bone resorption and interact with osteoblasts during bone remodeling.Ion channels and transporters located in the ruffled border or intracellular vesicles coordinate the transport of various ions and substrates,which is fundamental to the primary functions of osteoclasts.Numerous channels and transporters are implicated in bone metabolic disorders and genetic diseases.Among these,the voltage-gated chloride channel 7(ClC-7)and vacuolar proton ATPases(VATPase)represent the most well-characterized examples in osteoclasts. 展开更多
关键词 ruffled border channels transporters transporters intracellular vesicles bone resorption vacuolar proton atpases vatpase represent osteoclasts bone remodelingion
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ABCA5 lipid transporter is associated with a reduced risk of Parkinson’s disease 认领 引用
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作者 Jasmin Galper Nicolas Dzamko Woojin Scott Kim 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期669-670,共2页
A key pathological feature of Parkinson’s disease(PD)is that lysosomes are overwhelmed with cellular materials that need to be degraded and cleared.While the build-up of protein is characteristic of neurodegenerative... A key pathological feature of Parkinson’s disease(PD)is that lysosomes are overwhelmed with cellular materials that need to be degraded and cleared.While the build-up of protein is characteristic of neurodegenerative diseases such as PD and Alzheimer’s disease(AD)and is thought to reflect lysosome dysfunction,lipid accumulation may also contribute to and be indicative of severe lysosomal dysfunction.Much is known about the detrimental effects of glucosylceramide accumulation in PD lysosomes. 展开更多
关键词 neurodegenerative diseases lipid transporter abca lysosome protein build up Alzheimers disease cellular materials Parkinsons disease
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Sodium glucose transporter 2 inhibitors for heart failure 认领 引用
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作者 Daisuke Usuda Daiki Furukawa +24 位作者 Rikako Imaizumi Rikuo Ono Yuki Kaneoka Eri Nakajima Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita 《World Journal of Cardiology》 2026年第3期24-36,共13页
Heart failure(HF)is a leading cause of cardiovascular morbidity and mortality,affecting over 64 million individuals worldwide.Despite advances in guideline-directed medical therapy,patients with HF continue to experie... Heart failure(HF)is a leading cause of cardiovascular morbidity and mortality,affecting over 64 million individuals worldwide.Despite advances in guideline-directed medical therapy,patients with HF continue to experience poor outcomes,highlighting the need for novel therapeutic approaches.Sodium glucose transporter 2(SGLT2)inhibitors,initially developed for diabetes management,have emerged as groundbreaking therapies for HF.These agents demonstrate remarkable cardiovascular benefits that extend beyond their glucose-lowering effects,including significant reductions in HF hospitalization and cardiovascular mortality rates.Landmark trials including Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure,Empagliflozin Outcome Trial in Patients with Chronic Heart Failure with Reduced Ejection Fraction,Empagliflozin Outcome Trial in Patients with Chronic Heart Failure with Preserved Ejection Fraction,and Dapagliflozin Evaluation to Improve the Lives of Patients with Preserved Ejection Fraction Heart Failure have established the efficacy of SGLT2 inhibitors across the spectrum of HF phenotypes,regardless of diabetes status.The mechanisms underlying these benefits are multifaceted,involving improvements in cardiac energetics,mitochondrial function,reduction of oxidative stress,attenuation of inflammation,and favorable effects on cardiac remodeling and fibrosis.This comprehensive review examines the current evidence supporting the use of SGLT2 inhibitors in HF management,explores the mechanistic pathways responsible for their cardiovascular benefits,analyzes key clinical trial data,and discusses future prospects for this transformative drug class in cardiovascular medicine. 展开更多
关键词 Sodium glucose transporter 2 inhibitor Heart failure Cardiovascular benefit Mechanistic pathway Current evidence Prospects
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SsBMR1 as a putative ABC transporter is required for pathogenesis by promoting antioxidant export and antifungal resistance in Sclerotinia sclerotiorum 认领 引用
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作者 Yijuan Ding Yaru Chai +5 位作者 Sen Li Zhaohui Wu Minghong Zou Ling Zhang Rana Kusum Wei Qian 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第1期166-179,共14页
The plant pathogenic fungus Sclerotinia sclerotiorum is the causative agent of Sclerotinia stem rot(SSR)disease in most dicotyledons.Among the various proteins involved in drug efflux or substance transport,ATP-bindin... The plant pathogenic fungus Sclerotinia sclerotiorum is the causative agent of Sclerotinia stem rot(SSR)disease in most dicotyledons.Among the various proteins involved in drug efflux or substance transport,ATP-binding cassette(ABC)transporters constitute a superfamily of membrane-bound proteins that may play a crucial role in the survival of S.sclerotiorum.However,the expression patterns and functions of ABC transporter genes in S.sclerotiorum remain largely uncharacterized.This study characterized a highly expressed S.sclerotiorum ABC transporter gene during inoculation on host plants,Ss BMR1.Silencing Ss BMR1 resulted in a significant reduction in hyphal growth,infection cushion development,sclerotia formation,and virulence.Moreover,host-induced gene silencing(HIGS)of Ss BMR1 significantly enhanced plant resistance.Transcriptome and metabolomics analyses suggested that Ss BMR1 is involved in antioxidant and toxin transport,thereby influencing fungal defense and cell rescue mechanisms.In comparison to the wild-type strain,Ss BMR1 gene-silenced transformants exhibited a diminished response to extracellar oxidative stress and a decreased exporting of antioxidant glutathione.Tolerance assays further demonstrated the crucial role of Ss BMR1 in conferring resistance to the plant antifungal substances,camalexin and brassinin,as well as certain fungicides.Furthermore,Ss BMR1 gene-silenced transformants showed enhanced repression on virulence when sprayed with camalexin and brassinin on the leaves.Thus,Ss BMR1 likely contributes to virulence by facilitating the export of antioxidant and providing resistance against antifungal agents.The findings of this study provide valuable insights that could contribute to the development of novel management techniques for SSR. 展开更多
关键词 ABC transporter antifungal resistance glutathione pathogenesis Sclerotinia sclerotiorum
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An exploration into the transplacental transfer of microplastics through placental transporters 认领 引用
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作者 Binbin Guo Yawei Wang +4 位作者 Weilin Wang Ruining Guan Dongquan Li Qiyue Wang Chunyan Zhao 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第6期656-664,共9页
Microplastic(MP)and nanoplastic(NP)exposure has been proven to cause placental damage and fetal dysplasia in mammals.The distribution and accumulation of MPs and NPs in human placental tissue were partly explored.Howe... Microplastic(MP)and nanoplastic(NP)exposure has been proven to cause placental damage and fetal dysplasia in mammals.The distribution and accumulation of MPs and NPs in human placental tissue were partly explored.However,the underlying mechanisms remain poorly understood.In this work,the adsorption processes of polystyrene(PS)and polyethylene(PE)NPs with six representative placental transporters,including breast cancer resistance protein(BCRP),ATP-binding cassette transporter B1(MDR1),multi-drug resistance protein 1(MRP1),human equilibrium nucleoside transporter 1(hENT1),folate receptor?(FR?),and serotonin transporter(SERT)were simulated by molecular dynamics to explore the transplacental mechanism of NPs.The results suggested that the other five placental transporters could spontaneously adsorb on the surface of NPs except for the PE-BCRP system.In addition,by fitting the binding property parameters of NPs and placental proteins,including contact number,contact area,binding free energy,maximum adsorption number,surface water distribution,and secondary structure,a comprehensive binding capacity function was constructed for quantitative evaluation of nanoplastics-transporters adsorption ability.The values obtained based on the function directly reflected the strength of the binding ability between NPs and placental transporters.Based on the values,PS and PE NPs had similar abilities to promote placental transport by adsorbing the influx transporters.However,considering that three efflux transporters significantly inhibit the placental transport of PS NPs,the transplacental transport capacity of PE NPs was higher than that of PS NPs.The comprehensive binding capacity calculation system proposed in this research offers a new approach to quantitatively assess the risk of NPs placenta exposure and screen for potential toxic microplastics in the placenta. 展开更多
关键词 Nanoplastics Placental transporters Molecular dynamics(MD)simulation Transplacental transfer
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Ileal bile acid transporter inhibitors for chronic constipation in the elderly 认领 引用
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作者 Payila Satya Raghava Aneesh Venkatesh Vaithiyam +2 位作者 Ravi Teja Reddy Ashok Dalal Sanjeev Sachdeva 《World Journal of Gastrointestinal Pharmacology and Therapeutics》 2026年第1期1-8,共8页
We read with great interest and commended Sakai et al for their valuable study on the efficacy of elobixibat in elderly patients with chronic constipation(CC).This study provides valuable insights into the safety and ... We read with great interest and commended Sakai et al for their valuable study on the efficacy of elobixibat in elderly patients with chronic constipation(CC).This study provides valuable insights into the safety and efficacy of elobixibat in elderly patients with CC.We have a few critical points regarding the study methodology and evaluation of CC in the elderly population.The authors have not commented on the exclusion of possible drug-related constipation,as most of their elderly patients have comorbid illness,structural causes of constipation,evaluation of gastrointestinal motility,and advocating for a more comprehensive workup for CC in the elderly.This article also provides a comprehensive review of the workup of CC in the elderly,as well as a review of the available evidence on ileal bile acid transporter inhibitor-elobixibat in CC. 展开更多
关键词 Ileal bile acid transporter Elobixibat Chronic constipation Elderly Colonic motility
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Nutrient transporters in broiler chickens:intestinal gene expression profiles,functional roles,and influencing factors 认领 引用
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作者 Vahideh Shay Sadr Jose A.Quinteros +1 位作者 Sonia Yun Liu Reza Barekatain 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第2期591-612,共22页
The primary role of the gastrointestinal tract in broiler chickens is nutrient assimilation,with transporter proteins facilitating the uptake of amino acids,peptides,monosaccharides,fatty acids,and minerals across the... The primary role of the gastrointestinal tract in broiler chickens is nutrient assimilation,with transporter proteins facilitating the uptake of amino acids,peptides,monosaccharides,fatty acids,and minerals across the intestinal epithelium.Among these nutrient transporters,members of the solute carrier family are particularly important,and gene expression analyses targeting these transporters have provided informative insights into how birds adapt to diverse dietary,environmental,and physiological challenges to maintain nutrient homeostasis.These transporters are expressed either at the brush border membrane,where they facilitate the absorption of nutrients from the gut lumen into enterocytes,or at the basolateral membrane,where they mediate the transfer of nutrients from the enterocytes into the bloodstream.The expression of these transporters is influenced by a range of factors,including bird age,sex,intestinal segment,dietary substrate availability and source,as well as external stressors such as heat stress and pathogen exposure.While upregulation of transporter genes often suggests an enhanced capacity for nutrient uptake,it does not always correlate with improved growth performance,due to compensatory physiological responses and fluctuations in nutrient bioavailability.Understanding the regulation and functional dynamics of nutrient transporters presents valuable opportunities to develop targeted dietary and management strategies aimed at optimizing nutrient utilization and improving bird performance.This review summarizes current knowledge on the classification,function,and regulation of key nutrient transporters in broilers,highlights factors influencing their expression,and explores their implications for nutrition and production efficiency. 展开更多
关键词 Broiler chickens Gene expression Growth performance Nutrient homeostasis Nutrient transporters
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Analysis of Sulfate Transporter Gene Family 3 in Rice 认领 引用
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作者 LI Ruili XU Zhuang +4 位作者 WANG Wanxia WANG Huang ZHAO Hongyu XU Lei YI Keke 《Rice science》 SCIE CSCD 2025年第4期449-452,I0011-I0017,共4页
Sulfate transporters(SULTRs)facilitate sulfate uptake and transport in plants.In plants,SULTRs can be classified into four distinct functional groups,among which SULTR3 members are the least characterized,and their fu... Sulfate transporters(SULTRs)facilitate sulfate uptake and transport in plants.In plants,SULTRs can be classified into four distinct functional groups,among which SULTR3 members are the least characterized,and their functions have not yet been confirmed,especially for SULTR3 in rice.In this study,we analyzed the expression patterns,subcellular localization,and inorganic phosphate(Pi)transporter activity of SULTR3 proteins in yeast.Except for OsSULTR3.4,which localized to the plasma membrane,other OsSULTR3 members were localized to the endoplasmic reticulum(ER)membrane in rice protoplast cells. 展开更多
关键词 sulfate transporters sultrs facilitate inorganic phosphate transporter activity plasma membraneother sulfate transporters rice yeast expression patternssubcellular sultr
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Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior 认领 引用 被引量：2
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作者 Xirong Xu Shoumin Xuan +3 位作者 Shuai Chen Dan Liu Qian Xiao Jie Tu 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第6期1721-1734,共14页
The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain functio... The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with emotions.Specifically, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal mice.After knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was obviously mitigated. Additionally, administration of an excitatory amino acid transporter 2 inhibitor in the basolateral amygdala yielded a notable reduction in anxiety level among mice subjected to stress. These results suggest that basolateral amygdala astrocytic excitatory amino acid transporter 2 plays a role in in the regulation of unpredictable chronic mild stress-induced anxiety-like behavior by impacting the activity of local glutamatergic neurons, and targeting excitatory amino acid transporter 2 in the basolateral amygdala holds therapeutic promise for addressing anxiety disorders. 展开更多
关键词 anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter
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Identification of Sucrose Transporter(SUT)Genes Regulating Rice Yield and Quality 认领 引用 被引量：1
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作者 DUAN Yingqing LI Xiaoxue +9 位作者 WU Yawen JIAO Guiai MA Liuyang DONG Nannan CHEN Pengfei LI Xinwei CAO Ruijie CHEN Tianxiao HU Peisong WEI Xiangjin 《Rice science》 SCIE CSCD 2025年第3期287-291,I0012-I0021,共5页
Sucrose transporters(SUTs)contain multiple transmembrane domains that mediate sucrose transport and provide energy for plant growth and development.However,the role of OsSUTs in regulating rice quality and grain yield... Sucrose transporters(SUTs)contain multiple transmembrane domains that mediate sucrose transport and provide energy for plant growth and development.However,the role of OsSUTs in regulating rice quality and grain yield remains unclear.In this study,we identified five rice SUT genes(OsSUT1-OsSUT5)and examined their molecular characteristics and biological functions.OsSUT1,OsSUT2,and OsSUT4 were predominantly expressed in stems,while OsSUT3 and OsSUT5 showed higher expression in panicles.OsSUT1 and OsSUT4 are located on the plasma membrane,whereas OsSUT2,OsSUT3,and OsSUT5 are localized to the tonoplast. 展开更多
关键词 sucrose transporters suts contain sucrose transporters transmembrane domains ossut rice yield rice quality
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Intestinal transporters and oral absorption enhancing strategies based on these transporters 认领 引用
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作者 Ju Wang Yongbing Sun +3 位作者 Lingbang Meng Jianfang Feng Meng Cheng Liangxing Tu 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第5期82-98,共17页
Utilizing transporter-mediated drug delivery to achieve effective oral absorption emerges as a promising strategy.Researchers have been concentrated on discovering solutions to the issues of low solubility and poor pe... Utilizing transporter-mediated drug delivery to achieve effective oral absorption emerges as a promising strategy.Researchers have been concentrated on discovering solutions to the issues of low solubility and poor permeability of insoluble drugs,whereas,current reports have revealed that drug transporter proteins are abundantly expressed in the mucosa of intestinal epithelial cells,and that their mediated drug absorption effectively improved the bioavailability of orally administered drugs.There are two main categories based on the transporter mechanism,which include the family of ATP-binding cassette(ABC)transporters with efflux effects that reduce drug bioavailability and the family of solute carriers(SLC)transporters with uptake effects that promote drug absorption,respectively.Thus,we review studies of intestinal transporter-mediated delivery of drugs to enhance oral absorption,including the types of intestinal transporters,distribution characteristics,and strategies for enhancing oral absorption using transporter-mediated drug delivery systems are summarized,with the aim of providing important theoretical references for the development of intestinal-targeted delivery system. 展开更多
关键词 Intestinal transporter Bioavailability Oral delivery Intestinal absorption SLC transporters ABC transporters
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Chronic enteropathy associated with solute carrier organic anion transporter family member 2A1 gene:A case report and review of literature 认领 引用
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作者 Jun-Yao Wang Yun Liu +5 位作者 Jun Xu Fan Fan Peng You Tao Peng Yu-Lan Liu Ning Chen 《World Journal of Gastrointestinal Endoscopy》 2025年第12期177-185,共9页
BACKGROUND Chronic enteropathy associated with solute carrier organic anion transporter family member 2A1(SLCO2A1)(CEAS)is a rare autosomal recessive hereditary disease characterized by anemia,hypoproteinemia,abdomina... BACKGROUND Chronic enteropathy associated with solute carrier organic anion transporter family member 2A1(SLCO2A1)(CEAS)is a rare autosomal recessive hereditary disease characterized by anemia,hypoproteinemia,abdominal pain,diarrhea,and multiple shallow ulcers in the small intestine.Genetic analysis for SLCO2A1 mutations has identified more than 10 variant types,including the mostly reported c.940+1G>A splice site mutation.CASE SUMMARY Herein,we described a 33-year-old female patient who was admitted for anemia,edema,and a positive fecal occult blood test,unaccompanied by abdominal pain and diarrhea.She was diagnosed with CEAS due to compound heterozygous variants,c.940+1G>cA(splice-5)and c.1658T>A(p.Ile553Asn)in SLCO2A1,which had not been previously reported.Importantly,we reviewed 132 reported CEAS patients,which showed that anemia(87.3%)and hypoproteinemia(81%)were the most common symptoms.Nearly 25.8%of patients only had a positive result of fecal occult blood,without any symptoms of gastrointestinal bleeding.CONCLUSION In conclusion,fecal tests should be repeated in patients with anemia and edema to find clues for chronic enteropathy,including the rare cause-CEAS. 展开更多
关键词 Chronic enteropathy Solute carrier organic anion transporter family member 2A1 Small intestinal ulcer Anemia Edema Prostaglandin transporter Organic anion transporting polypeptide 2A1 Case report
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OsNCED3 and OsPYL1 promote the closure of rice florets by regulating sugar transporters through endogenous abscisic acid 认领 引用 被引量：2
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作者 Xiawan Zhai Wenbin Kai +2 位作者 Youming Huang Jinyin Chen Xiaochun Zeng 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2025年第2期441-452,共12页
Rice is the world's largest food crop,but it often encounters flowering asynchronization problems during hybrid rice seed production.In addition,the slow closure of female florets leads to seed mildew and affects ... Rice is the world's largest food crop,but it often encounters flowering asynchronization problems during hybrid rice seed production.In addition,the slow closure of female florets leads to seed mildew and affects the quality.The hormone abscisic acid(ABA)plays a crucial role in plant responses to abiotic stresses.Previous studies showed that exogenous ABA promotes floret closure,although the molecular mechanisms and effects of endogenous ABA on floret closure remain unknown.In this study,the effect of endogenous ABA on floret closure and the molecular mechanism by which ABA promotes floret closure through sugar transporters were investigated by changing the expression levels of OsNCED3 and OsPYL1 in rice.The results showed that overexpression(OE)-OsNCED3increased the endogenous ABA level of florets.Florets closed 5.91 min earlier and OsNCED3 gene knockout line delayed the closure of florets by 5.08 min compared with the wild type.In addition,OsPYL1 regulated the endogenous ABA content and changed the sensitivity to ABA such that the floret closure times for OE and CRISPR-Cas9(CR)were 9.84 min earlier and 12.78 min later,respectively,resulting in an increase in the split husk rate to 15.4%.The gene expression levels of some sugar transporters(STs)changed.The OsPYL1 and OsSWEET4proteins could interact on the cell membrane.These results indicate that ABA promotes the closure of rice florets and the enhanced sensitivity to ABA promotes this effect even more.The molecular mechanism is mainly related to downstream sugar transporters that respond to the ABA signaling pathway,especially OsSWEET4. 展开更多
关键词 rice floret closure sugar transporter abscisic acid seed quality
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Vacuolar sugar transporter OsERD5 increases rice tillering and yield by modulating intracellular hexose homeostasis 认领 引用 被引量：2
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作者 Mingjuan Li Zhen Li +8 位作者 Hongye Li Qidong Zhu Dong Liu Ben Zhang Youpeng Chen Junyan Chen Huimin Zhang Nader Saad Elsayed Zhenhua Zhang 《The Crop Journal》 SCIE CAS CSCD 2025年第3期716-726,共11页
The early responsive to dehydration-like(ERDL or ERD)subfamily,subclade within the monosaccharide transporter(MST)superfamily,is crucial in the regulation of growth and seed yield in Arabidopsis.Here,we identified Os ... The early responsive to dehydration-like(ERDL or ERD)subfamily,subclade within the monosaccharide transporter(MST)superfamily,is crucial in the regulation of growth and seed yield in Arabidopsis.Here,we identified Os ERD5 as an At ERDL6 homologue and explored the function of Os ERD5.We found that Os ERD5 overexpression significantly enhanced the tiller number and grain yield of rice.Os ERD5 was widely expressed in aboveground tissues,encoded a tonoplast-localized protein,and exhibited transport activities for fructose,glucose and mannose when expressed in yeast.Expression character assay revealed that Os ERD5 mediated hexose efflux across tonoplasts and participated in maintaining the diurnal rhythm-regulated intracellular hexose homeostasis.Additional physiological and molecular evidence showed that Os ERD5 overexpression promoted vacuolar glucose efflux,enhanced sucrose synthesis and transport,increased sugar content in the shoot base,and promoted rice tillering by activating the synthesis of cytokinin simultaneously repressing strigolactone and gibberellin signaling.This study elucidates the function of Os ERD5 and the mechanism underlying the overexpression of Os ERD5 increasing rice tillering and yield. 展开更多
关键词 Rice(Oryza sativa L.) Monosaccharide transporter Cytoplasm sugar homeostasis Sucrose transport Tillering
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