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A Koopman-Based Equivalent-Input-Disturbance Tremor-Suppressing Strategy 认领 引用
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作者 Mingyuan Xie Jinhua She +3 位作者 Zhen-Tao Liu Jian Huang Daiki Sato Seiichi Kawata 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2026年第6期1521-1523,共3页
Dear Editor,This letter introduces a novel Koopman-based equivalent-inputdisturbance(EID)approach to enhance tremor suppression performance.Since the first-order linear model used in the conventional EID approach cann... Dear Editor,This letter introduces a novel Koopman-based equivalent-inputdisturbance(EID)approach to enhance tremor suppression performance.Since the first-order linear model used in the conventional EID approach cannot accurately describe the wrist-exoskeleton system,we propose a Koopman modeling framework to construct a high-precision linear model.Furthermore,we incorporate an additional gain parameter into the EID estimator to improve the tremor suppression performance.Simulation results demonstrate the superiority of our approach. 展开更多
关键词 enhance tremor suppression performancesince Koopman based modeling koopman modeling framework tremor suppression High precision linear model Gain parameter Equivalent input disturbance
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Prediction of rockburst risk induced by mine tremor using ensemble learning techniques 认领 引用
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作者 Changkun Qin Wusheng Zhao +2 位作者 Weizhong Chen Xiufeng Zhang Peiyao Xie 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第3期1937-1953,共17页
With the increasing depth and intensity of coal mining operations,high-energy mine tremors have become a major trigger for rockburst disasters,posing severe threats to mine safety.Conventional rockburst risk assessmen... With the increasing depth and intensity of coal mining operations,high-energy mine tremors have become a major trigger for rockburst disasters,posing severe threats to mine safety.Conventional rockburst risk assessment methods either lack real-time adaptability or rely heavily on qualitative microseismic data analysis,limiting their effectiveness in dynamic early warning.To address these limitations,this study proposed a predictive framework for rockburst risk assessment by integrating ensemble learning algorithms with Bayesian optimization.A dataset was constructed using a sliding time window approach,linking the highest MS energy in the subsequent days with predefined risk levels.Both undersampling and oversampling strategies were employed to mitigate class imbalance,and their performance was evaluated.Three ensemble models,i.e.CatBoost,Random Forest,and LightGBM,were developed,and their hyperparameters were optimized using Bayesian techniques to enhance predictive performance.The models were validated using MS data from the 6303 and 6306 working faces at the Dongtan Coal Mine.All three ensemble models outperformed conventional classification methods,particularly in accurately predicting high-risk categories.Among them,the CatBoost model exhibited the best performance,with an accuracy of 89.47%and an F1¯-score of 90.62%.Furthermore,SHapley Additive exPlanations analysis was used to enhance model interpretability,identifying key MS indicators influencing rockburst risk predictions.This study provides a systematic approach for leveraging MS data and machine learning to improve an early warning system for rockburst hazards,offering valuable insights for underground mining safety management. 展开更多
关键词 Mine tremor Rockburst risk Prediction Ensemble learning Sliding window method
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Cerebral cortex contributions to Parkinson's disease tremor:what exactly generates the tremor? 认领 引用
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作者 Manuel Bange Hao Ding Muthuraman Muthuraman 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第12期3535-3536,共2页
Pathological tremor is one of the cardinal symptoms in Parkinson's disease (PD).Tremor is comprised of involuntary,rhythmic,a nd oscillating movements that can vary according to the circumstances under which they ... Pathological tremor is one of the cardinal symptoms in Parkinson's disease (PD).Tremor is comprised of involuntary,rhythmic,a nd oscillating movements that can vary according to the circumstances under which they occur,the body parts that are involved,and the frequency at which they present.For example,tremors can be mild to severe,are stress sensitive,and can affect arms,legs,or the head (Dirkx and Bologna,2022). 展开更多
关键词 tremor cortex exactly
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4D printing of soft orthoses for tremor suppression 认领 引用 被引量：2
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作者 Moslem Mohammadi Ali Zolfagharian +2 位作者 Mahdi Bodaghi Yong Xiang Abbas Z.Kouzani 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2022年第4期786-807,共22页
Tremor is an involuntary and oscillatory movement disorder that makes daily activities difficult for affected patients. Hand tremor-suppression orthoses are noninvasive, wearable devices designed to mitigate tremors. ... Tremor is an involuntary and oscillatory movement disorder that makes daily activities difficult for affected patients. Hand tremor-suppression orthoses are noninvasive, wearable devices designed to mitigate tremors. Various studies have shown that these devices are effective, economical, and safe;however, they have drawbacks such as large weight, awkward shape, and rigid parts. This study investigates different types of tremor-suppression orthoses and discusses their efficiency, mechanism,benefits, and disadvantages. First, various orthoses(with passive, semi-active, and active mechanisms) are described in detail.Next, we look at how additive manufacturing(AM) has progressed recently in making sensors and actuators for application in tremor orthoses. Then, the materials used in AM are further analyzed. It is found that traditional manufacturing problems can be solved with the help of AM techniques, like making orthoses that are affordable, lighter, and more customizable. Another concept being discussed is using smart materials and AM methods, such as four-dimensional(4D) printing, to make orthoses that are more comfortable and efficient. 展开更多
关键词 Tremor suppression Parkinson’s disease Essential tremor Additive manufacturing 4D printing
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HPLC法测定tremor大鼠脑组织中谷氨酸和GABA含量 认领 引用 被引量：19
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作者 俞军龄 陈再兴 +6 位作者 毛小元 孟秀君 郭凤 刘睿 吴坤灿 谢妮 蔡际群 《中国药理学通报》 CAS 北大核心 2009年第11期1530-1533,共4页
目的建立测定tremor大鼠(tm)脑内海马组织中GLU及GABA浓度的高效液相色谱(HPLC)方法。方法冰上剥离13wk的tm/Wistar大鼠海马组织,低温匀浆处理,利用邻苯二甲醛(OPA)柱前衍生HPLC法结合荧光检测器测定GLU和GABA的含量。0.1mol·L-1... 目的建立测定tremor大鼠(tm)脑内海马组织中GLU及GABA浓度的高效液相色谱(HPLC)方法。方法冰上剥离13wk的tm/Wistar大鼠海马组织,低温匀浆处理,利用邻苯二甲醛(OPA)柱前衍生HPLC法结合荧光检测器测定GLU和GABA的含量。0.1mol·L-1醋酸钾和甲醇进行二元梯度洗脱,峰面积定量。结果GLU的线性方程为Y^=1E+06X(r2=0.9937),线性范围为0.15～5.88mg·L-1,具有良好的线性关系,在0.74、1.47、3.68mg.L-13个浓度下样本回收率分别为97.7%、98.9%、100.5%;样品中GLU日内变异系数为3.8%,隔日测定后,日间变异系数为5.9%;GABA的线性方程为Y^=4E+06X(r2=0.998),线性范围为0.10～2.15mg·L-1,具有良好的线性关系,在0.2、0.5、1.0mg·L-13个浓度下样本回收率分别为98.3%、101.0%、102.7%;样品GABA日内变异系数为2.3%,隔日测定后,日间变异系数为3.9%。结论该方法较简便、快速且干扰相对较小,满足测定要求,可用于氨基酸的含量测定研究。 展开更多
关键词 谷氨酸 γ-氨基丁酸 OPA柱前衍生化 反相高效液相色谱法 tremor大鼠 Wistar大鼠 癫痫
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Voltage adjustment improves rigidity and tremor in Parkinson's disease patients receiving deep brain stimulation 认领 引用 被引量：1
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作者 Shao-hua Xu Chao Yang +11 位作者 Wen-biao Xian Jing Gu Jin-long Liu Lu-lu Jiang Jing Ye Yan-mei Liu Qi-yu Guo Yi-fan Zheng Lei Wu Wan-ru Chen Zhong pei Ling Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第2期347-352,共6页
Deep brain stimulation of the subthalamic nucleus is recognized as the most effective treatment for moderate and advanced Parkinson＇s disease. Programming of the stimulation parameters is important for maintaining th... Deep brain stimulation of the subthalamic nucleus is recognized as the most effective treatment for moderate and advanced Parkinson＇s disease. Programming of the stimulation parameters is important for maintaining the efficacy of deep brain stimulation. Voltage is consid- ered to be the most effective programming parameter. The present study is a retrospective analysis of six patients with Parkinson＇s disease （four men and two women, aged 37-65 years）, who underwent bilateral deep brain stimulation of the subthalamic nucleus at the First Affiliated Hospital of Sun Yat-sen University, China, and who subsequently adjusted only the stimulation voltage. We evaluated motor symptom severity using the Unified Parkinson＇s Disease Rating Scale Part III, symptom progression using the Hoehn and Yahr scale, and the levodopa equivalent daily dose, before surgery and 1 and 2 years after surgery. The 2-year follow-up results show that rigidity and tremor improved, and clinical symptoms were reduced, while pulse width was maintained at 60 ps and frequency at 130 Hz. Voltage adjust- ment alone is particularly suitable for patients who cannot tolerate multiparameter program adjustment. Levodopa equivalent daily dose was markedly reduced 1 and 2 years after surgery compared with baseline. Our results confirm that rigidity, tremor and bradykinesia can be best alleviated by voltage adjustment. The trial was registered at ClinicalTrials.gov （identifier： NCT01934881）. 展开更多
关键词 nerve regeneration deep brain stimulation Parkinson＇s disease subthalamic nucleus voltage pulse width frequency tremor rigidity bradykinesia axial symptoms neural regeneration
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Anomalous tremor before 2008 Ms8.0 Wenchuan earthquake:a review 认领 引用 被引量：2
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作者 Hao Xiaoguang Hu Xiaogang Tian Lianghui 《Geodesy and Geodynamics》 EI 2011年第3期56-60,共5页
In this paper we give a review of several previously published papers on anomalous tremors observed before the 2008 Ms8.0 Weuchuan earthquake.Based on the observed time and frequency shifts between coastal and inland ... In this paper we give a review of several previously published papers on anomalous tremors observed before the 2008 Ms8.0 Weuchuan earthquake.Based on the observed time and frequency shifts between coastal and inland stations,we discussed some methods to distinguish different kinds of microseisms,and speculated that a pre-earthquake typhoon might have caused a"mainland-originated microseism"which in turn trig-gered the earthquake. 展开更多
关键词 Ms8.0 Wenchuan earthquake anomalous tremors before earthquake review microseisms ty-phoon
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Visual function alterations in essential tremor: A case report 认领 引用
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作者 David P.Pinero Begona Monllor +2 位作者 Vicenta Moncho Vicent J.Camps Dolores de Fez 《Journal of Innovative Optical Health Sciences》 SCIE EI 2015年第5期94-98,共5页
Our purpose is to report alterations in contrast sensitivity function(CSF)and in the magno,parvo and koniocellular visual pathways by means of a multichannel perimeter in case of an essential tremor(ET).A complete eva... Our purpose is to report alterations in contrast sensitivity function(CSF)and in the magno,parvo and koniocellular visual pathways by means of a multichannel perimeter in case of an essential tremor(ET).A complete evaluation of the visual function was performed in a 69-year old patient,including the analysis of the chromatic discrimination by the Fansworth–Munsell 100 hue test,the measurement of the CSF by the CSV-1000E test,and the detection of potential alteration patterns in the magno,parvo and koniocellular visual pathways by means of a multichannel perimeter.Visual acuity and intraocular pressure(IOP)were within the ranges of normality in both eyes.No abnormalities were detected in the fundoscopic examination and in the optical coherence tomography(OCT)exam.The results of the color vision examination were also within the ranges of normality.A signi¯cant decrease in the achromatic CSFs for right eye(RE)and left eye(LE)was detected for all spatial frequencies.The statistical global values provided by the multichannel perimeter confirms that there were significant absolute sensitivity losses compared to the normal pattern in RE.In the LE,only a statistically significant decrease in sensitivity was detected for the blue-yellow(BY)channel.The pattern standard deviation(PSD)values obtained in our patient indicated that there were significant localized losses compared to the normality pattern in the achromatic channel of the RE and in the red-green(RG)channel of the LE.Some color vision alterations may be present in ET that cannot be detected with conventional color vision tests,such as the FM 100 Hue. 展开更多
关键词 Multichannel perimetry essential tremor color vision visual pathways contrast sensitivity
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Tremor suppression strategy of the tremor suppression robot 认领 引用
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作者 赵杰 李军强 +1 位作者 樊继壮 臧希喆 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2012年第1期1-6,共6页
Based on the development of the performance of magnetorheological damper,the tremor suppression strategy that uses angle displacement sensor and force sensor to sense the information of the tremor and uses the fuzzy n... Based on the development of the performance of magnetorheological damper,the tremor suppression strategy that uses angle displacement sensor and force sensor to sense the information of the tremor and uses the fuzzy neural network as the control algorithm is presented. The information of the maximum tremor torque can be achieved exactly by means fusing the data of displacement sensor and the data of force sensor. Due to the slow change of the maximum tremor torque,the fuzzy neural network with single input variable and single output variable is adopted as the control algorithm,and the mathematic model of fuzzy neural network is worked out. The elbow tremor suppression model is established to provide tremor information for fuzzy neural network training and tremor suppression strategy simulation,then the off-line fuzzy neural network training is finished with the selected training data set,and the tremor suppression strategy is simulated. Simulation results show that the tremor suppression strategy has presented is effectually for the tremor suppression. 展开更多
关键词 magnetorheological damper fuzzy neural network data fusion tremor suppression strategy
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Assistive techniques and their added value for tremor classification in multiple sclerosis 认领 引用
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作者 Nabin Koirala Abdulnasir Hossen +2 位作者 Ioannis U.Isaias Jens Volkmann Muthuraman Muthuraman 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第5期977-978,共2页
Tremor occurs in about half of multiple sclerosis(MS)patients.MS tremor has a broad frequency range of 2.5-7 Hz,with a higher prevalence of postural tremor(44%)compared to intentional tremor(6%)(Alusi et al.,2001).Tre... Tremor occurs in about half of multiple sclerosis(MS)patients.MS tremor has a broad frequency range of 2.5-7 Hz,with a higher prevalence of postural tremor(44%)compared to intentional tremor(6%)(Alusi et al.,2001).Tremor may affect the upper and lower extremities,head,and trunk,and may even affect the vocal cords in isolated cases of palatal tremor.MS tremor is classically attributed to lesions of the brain stem,cerebellum,or cerebellar peduncles,and tremor intensity has been shown to correlate with the number of lesions or their functional connections.However,recent work has demonstrated that inflammatory damage to the cerebello-thalamic and cortico-thalamic pathways might also play an important role in causing tremor,as it co-occurs with other signs and symptoms of MS such as dysarthria,dysmetria,dysdiadochokinesia,and dystonia(Alusi et al.,2001). 展开更多
关键词 tremor sclerosis
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Functional magnetic resonance imaging of regional homogeneity changes in parkinsonian resting tremor 认领 引用
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作者 Xian Liu Bo Liu +1 位作者 Jun Chen Zhiguang Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第11期811-815,共5页
Regional homogeneity analysis of low-frequency blood oxygenation level-dependent signals from neighboring voxels enables the analysis of local neuronal synchrony.Both structural magnetic resonance imaging and resting-... Regional homogeneity analysis of low-frequency blood oxygenation level-dependent signals from neighboring voxels enables the analysis of local neuronal synchrony.Both structural magnetic resonance imaging and resting-state functional magnetic resonance imaging scans were collected from nine Parkinson's disease patients with right resting tremor,and from eight age-matched normal controls.Regional homogeneity was compared between Parkinson's disease patients and controls.The results revealed that regional homogeneity was increased in several brain regions,including the right precuneus,right superior parietal gyrus,left anterior cingulate cortex,right middle frontal gyrus and right inferior frontal gyrus.Conversely,regional homogeneity was decreased in the cerebellar vermis in Parkinson's disease patients compared with healthy controls. 展开更多
关键词 Parkinson's disease resting tremor regional homogeneity functional magnetic resonance imaging resting state brain activity
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Tremor suppression in master-slave robot remote welding system 认领 引用
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作者 陈洪堂 李海超 +1 位作者 高洪明 吴林 《China Welding》 EI CAS 2011年第2期63-66,共4页
Welding seam tracking precision was decreased due to human hand tremor during the master-slave welding teleoperation. To solve this problem, a master-slave robot remote welding system was built, the system consisted o... Welding seam tracking precision was decreased due to human hand tremor during the master-slave welding teleoperation. To solve this problem, a master-slave robot remote welding system was built, the system consisted of a master manipulator with six degree of freedom （ DOF ） , an industrial computer control system and a slave Motoman HP3 J robot, and human hand tremor and digital filtering were discussed. An optimal digital filter was designed to clean human tremor signal for improving the welding seam tracking precision. The experimental results show that the digital filter suppresses the operator＇ s tremor signal. 展开更多
关键词 remote welding master-slave teleoperation hand tremor digital filtering
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Tremor Suppression Method via Magnetorheological Damper and Fuzzy Neural Network Control 认领 引用
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作者 李军强 臧希喆 赵杰 《Journal of Donghua University(English Edition)》 EI CAS 2010年第4期486-490,共5页
Based on the performance of magnetorheological damper we have developed,a tremor suppression method using human limb nonrigid characteristic was presented.The tremor suppression machine was designed,and the measure pa... Based on the performance of magnetorheological damper we have developed,a tremor suppression method using human limb nonrigid characteristic was presented.The tremor suppression machine was designed,and the measure part and the tremor suppression part were separated.Subsequently,the mathematic models of fuzzy neural network and elbow nonrigid tremor were worked out.Using selected training data set,the off-line fuzzy neural network training was finished.Then the tremor suppression method was simulated in Matlab.From the simulation results,it is found that the tremor suppression method has presented suppresses tremor effectively,and the tremor amplitude and tremor suppression torque can be controlled with angle displacement sensor. 展开更多
关键词 magnetorheological damper nonrigid body fuzzy neural network tremor suppression
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Injury of the dentatorubrothalamic tract in patients with post-traumatic tremor following mild traumatic brain injury: a case-control study 认领 引用
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作者 Sung Ho Jang Han Do Lee 《Neural Regeneration Research》 SCIE CAS CSCD 2020年第11期2063-2066,共4页
Post-traumatic movement disorder is one of the sequelae of traumatic brain injury. The dentatorubrothalamic tract(DRTT) is reported to be involved in the control of movement. Therefore, injury of the DRTT can be accom... Post-traumatic movement disorder is one of the sequelae of traumatic brain injury. The dentatorubrothalamic tract(DRTT) is reported to be involved in the control of movement. Therefore, injury of the DRTT can be accompanied by abnormal movements, including ataxia, tremor, or dystonia. We investigated DRTT injuries in 27 patients who showed post-traumatic tremor in at least one of four extremities following mild traumatic brain injury. We classified DRTT injuries based on diffusion tensor tractography parameters and configuration: type A: the DRTT showed narrowing, type B: the DRTT showed partial tearing, and type C: the DRTT showed discontinuation. Fractional anisotropy and fiber number of the DRTT were significantly decreased in patients compared with the healthy controls. Based on our DRTT injury classification, among the 54 hemispheres of the 27 patients, type A injury occurred in 22 hemispheres(40.7%) of 17 patients, type B injury was present in 15 hemispheres(27.7%) of 10 patients, and type C injury was observed in 8 hemispheres(14.8%) of 6 patients. Our results suggest that diffusion tensor tractography-based evaluation of the DRTT would be useful when determining cause of post-traumatic tremor in patients with mild traumatic brain injury. The study protocol was approved by the Institutional Review Board of Yeungnam University Hospital(YUMC-2018-09-007) on September 5, 2018. 展开更多
关键词 dentatorubrothalamic tract diffusion tensor imaging diffusion tensor tractography fiber number fractional anisotropy mild traumatic brain injury post-traumatic tremor region of interest
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Neural computational modeling reveals a major role of corticospinal gating of central oscillations in the generation of essential tremor 认领 引用 被引量：2
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作者 Hong-en Qu Chuanxin M.Niu +4 位作者 Si Li Man-zhao Hao Zi-xiang Hu Qing Xie Ning Lan 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第12期2035-2044,共10页
Essential tremor, also referred to as familial tremor, is an autosomal dominant genetic disease and the most common movement disorder. It typically involves a postural and motor tremor of the hands, head or other part... Essential tremor, also referred to as familial tremor, is an autosomal dominant genetic disease and the most common movement disorder. It typically involves a postural and motor tremor of the hands, head or other part of the body. Essential tremor is driven by a central oscillation signal in the brain. However, the corticospinal mechanisms involved in the generation of essential tremor are unclear. Therefore, in this study, we used a neural computational model that includes both monosynaptic and multisynaptic corticospinal pathways interacting with a propriospinal neuronal network. A virtual arm model is driven by the central oscillation signal to simulate tremor activity behavior. Cortical descending commands are classified as alpha or gamma through monosynaptic or multisynaptic corticospinal pathways, which converge respectively on alpha or gamma motoneurons in the spinal cord. Several scenarios are evaluated based on the central oscillation signal passing down to the spinal motoneurons via each descending pathway. The simulated behaviors are compared with clinical essential tremor characteristics to identify the corticospinal pathways responsible for transmitting the central oscillation signal. A propriospinal neuron with strong cortical inhibition performs a gating function in the generation of essential tremor. Our results indicate that the propriospinal neuronal network is essential for relaying the central oscillation signal and the production of essential tremor. 展开更多
关键词 nerve regeneration neurodegeneration essential tremor propriospinal neurons motoneuron reflex modeling motor control oscillation neurological disorder movement disorder computational neuroscience neural regeneration
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A Smart Wearable Ring Device for Sensing Hand Tremor of Parkinson’s Patients 认领 引用 被引量：3
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作者 Haixia Yang Yixian Shen +3 位作者 Wei Zhuang Chunming Gao Dong Dai Weigong Zhang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2021年第3期1217-1238,共22页
Parkinson’s disease(PD)is a very common neurodegenerative disease that occurs mostly in the elderly.There are many main clinical manifestations of PD,such as tremor,bradykinesia,muscle rigidity,etc.Based on the curre... Parkinson’s disease(PD)is a very common neurodegenerative disease that occurs mostly in the elderly.There are many main clinical manifestations of PD,such as tremor,bradykinesia,muscle rigidity,etc.Based on the current research on PD,the accurate and convenient detection of early symptoms is the key to detect PD.With the development of microelectronic and sensor technology,it is much easier to measure the barely noticeable tremor in just one hand for the early detection of Parkinson’s disease.In this paper,we present a smart wearable device for detecting hand tremor,in which MPU6050(MIDI Processing Unit)consisting of a 3-axis gyroscope and a 3-axis accelerometer is used to collect acceleration and angular velocity of fingers.By analyzing the time of specific finger movements,we successfully recognized the tremor signals with high accuracy.Meanwhile,with Bluetooth 4.0(Bluetooth Low Energy,BLE)and networking terminal ability,tremor data can be transferred to a monitoring device in real time with extremely lowenergy consumption.The experimental results have shown that the proposed device(smart ring)is convenient for long-term tremor detection which is vital for early detection and treatment for Parkinson’s disease. 展开更多
关键词 Parkinson’s disease tremor detection IMU sensor MPU6050 BLE
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Magnetic resonance-guided focused ultrasound for essential tremor:a prospective,single center,single-arm study 认领 引用 被引量：1
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作者 Rui Zong Xuemei Li +10 位作者 Chunyu Yin Jianfeng He Dekang Zhang Xiangbing Bian Lichao Huang Jiayou Zhou Zhipei Ling Lin Ma Xin Lou Longsheng Pan Xinguang Yu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期2075-2080,共6页
The safety and effectiveness of magnetic resonance-guided focused ultrasound thalamotomy has been broadly established and validated for the treatment of essential tremor.In 2018,the first magnetic resonance-guided foc... The safety and effectiveness of magnetic resonance-guided focused ultrasound thalamotomy has been broadly established and validated for the treatment of essential tremor.In 2018,the first magnetic resonance-guided focused ultrasound system in Chinese mainland was installed at the First Medical Center of the PLA General Hospital.This prospective,single center,open-label,single-arm study was part of a worldwide prospective multicenter clinical trial(ClinicalTrials.gov Identifier:NCT03253991)conducted to confirm the safety and efficacy of magnetic resonance-guided focused ultrasound for treating essential tremor in the local population.From 2019 to 2020,10 patients with medication refractory essential tremor were recruited into this open-label,single arm study.The treatment efficacy was determined using the Clinical Rating Scale for Tremor.Safety was evaluated according to the incidence and severity of adverse events.All of the subjects underwent a unilateral thalamotomy targeting the ventral intermediate nucleus.At the baseline assessment,the estimated marginal mean of the Clinical Rating Scale for Tremor total score was 58.3±3.6,and this improved after treatment to 23.1±6.4 at a 12-month follow-up assessment.A total of 50 adverse events were recorded,and 2 were defined as serious.The most common intraoperative adverse events were nausea and headache.The most frequent postoperative adverse events were paresthesia and equilibrium disorder.Most of the adverse events were mild and usually disappeared within a few days.Our findings suggest that magnetic resonance-guided focused ultrasound for the treatment of essential tremor is effective,with a good safety profile,for patients in Chinese mainland. 展开更多
关键词 efficacy essential tremor magnetic resonance-guided focused ultrasound(MRgFUS) movement disorder safety stereotactic therapy thalamotomy ventral intermediate nucleus
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Objective tinnitus secondary to palatal tremor:Two case reports and brief literature review 认领 引用 被引量：1
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作者 Raúl Mellidez Acosta Miguel Saro-Buendía +2 位作者 Lidia Torres García Maria Antonia Marcos Pena Carlos De Paula Vernetta 《Journal of Otology》 CAS CSCD 2022年第2期107-110,共4页
Objective tinnitus is defined as a type of tinnitus perceived by both the patient and external observer.This paper presents two cases of objective tinnitus related to palatal tremor,along with a literature review.Pala... Objective tinnitus is defined as a type of tinnitus perceived by both the patient and external observer.This paper presents two cases of objective tinnitus related to palatal tremor,along with a literature review.Palatal tremor is a condition characterized by soft palate involuntary contractions.Two types of palatal tremor have been described:symptomatic palatal tremor and essential palatal tremor,with different clinical manifestations.Diagnostic workup is based on medical history and physical examination,including direct oropharynx exploration and cavum visualization through nasopharyngoscopy.Brain MRI is mandatory in all cases.If a secondary origin is suspected,additional lab tests should be performed based on clinical suspicion.First-line treatment is botulinum toxin injection into the levator veli palatini and tensor veli palatini muscles,with velopharyngeal insufficiency being its main adverse effect.Other medications have not been shown to be effective. 展开更多
关键词 Objetive tinnitus Palatal tremor Botox injection
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Gas-dynamic phenomena caused by rock mass tremors and rock bursts 认领 引用 被引量：11
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作者 Stanislaw Wasilewski 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2020年第3期413-420,共8页
Similar to coal, rock and gas ejections, rock mass tremors and rock bursts are among the most serious natural hazards accompanying the underground extraction of coal. Gas-dynamic phenomena caused by rock mass tremors ... Similar to coal, rock and gas ejections, rock mass tremors and rock bursts are among the most serious natural hazards accompanying the underground extraction of coal. Gas-dynamic phenomena caused by rock mass tremors and rock bursts observed as transient states of air parameters in mining headings,are usually generated as a result of a change in the geometry of headings and the release of considerable amounts of gases. Particular significance is attributed to transient states caused by disasters, which are often accompanied by rapid incidents, presenting threats to the life and health of the underground crew.In Polish mining there are known examples of transient states of air parameters recorded during gasdynamic phenomena, e.g. tremors and rock bursts. The paper presents the case studies of rapid seismic incidents to show how records in mine monitoring systems broaden the knowledge about the transient states of air parameters in mining headings generated because of them. 展开更多
关键词 Rock mass tremors Rock bursts Gas-dynamic phenomena Transient states of air parameters Mine monitoring systems
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Quantifying Kinematic Tremor in an NGLY1-Deficient Individual: A Case Study 认领 引用 被引量：2
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作者 Brock Futrell Christopher Alexander Malaya +6 位作者 Dacia Martinez Diaz Christian Alfaro Hannah Elizabeth Gustafson Subhalakshmi Chandrasekaran Rhea Mohan Phatak Bernhard Suter Charles Shannon Layne 《Case Reports in Clinical Medicine》 2024年第1期25-36,共12页
NGLY1 Deficiency is an autosomal recessive congenital disorder that has been identified in less than 100 individuals. Most individuals with NGLY1 Deficiency display hyperkinetic movement disorders, including choreifor... NGLY1 Deficiency is an autosomal recessive congenital disorder that has been identified in less than 100 individuals. Most individuals with NGLY1 Deficiency display hyperkinetic movement disorders, including choreiform, athetoid, dystonic myoclonic, dyskinetic, and dysmetric movements. Developing a consistent and concise consensus on the classification and evaluation of tremors is essential to forward the research and treatment of tremors. It has also been reported that some individuals with NGLY1 Deficiency demonstrate tremor, but such tremor has never been formally investigated. The primary objective of this study is to determine if an individual with NGLY1 Deficiency demonstrates an identifiable tremor during a series of arm movements and, if so, describe the frequency and power characteristics of that tremor. Arm movement kinematics were obtained using a 16-camera Vicon system, and time series trajectory waveforms for three planes of a marker placed on the hand were developed. Custom MATLAB scripts were utilized to compute Fast Fourier Transformations of the data within the identified waveform segments. A mean frequency of 2.30 Hz (SD = 1.05) with a mean power of 5.02 |P1(f)| (SD = 4.63) suggests that our participant’s kinematic data did display a persistent tremor in both hands across all tasks and movement planes. Analyses of the reaching hand and the non-reaching hand suggest the participant displayed an action tremor in both postural and intention (kinetic) tremors. Future directions should include assessing additional individuals with NGLY1 Deficiency to determine if the tremor is a distinguishable disorder behavior. Additionally, evaluating other anatomical sites, such as the elbow, head, and lower limbs, would provide further insights into the characteristics of this tremor. 展开更多
关键词 Tremor NGLY Fast Fourier Transformation Reaching Hyperkinetic Movement
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