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Characteristics and mechanisms of subcutaneous and visceral adipose tissue aging 认领 引用
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作者 Peng Xu Yikai Wang Kai Liu 《Chinese Journal of Plastic and Reconstructive Surgery》 2024年第2期94-97,共4页
Aging is one of the most significant health challenges worldwide and is a primary cause of chronic diseases and physiological decline.Among the myriad changes that occur with aging,alterations in adipose tissue distri... Aging is one of the most significant health challenges worldwide and is a primary cause of chronic diseases and physiological decline.Among the myriad changes that occur with aging,alterations in adipose tissue distribution and function have gained considerable attention because of their profound impact on metabolic health and overall well-being.Subcutaneous adipose tissue(SAT)and visceral adipose tissue(VAT)are the two major depots of white adipose tissue,each with distinct roles in metabolism and health.Understanding the characteristics and underlying mechanisms of SAT and VAT is crucial for elucidating the aging process and developing strategies to promote healthy aging.This review focuses on delineating and analyzing the characteristics and intrinsic mechanisms underlying the aging of subcutaneous and visceral adipose tissue during the aging process,which can contribute to a better understanding of the aging process and enhance healthy aging. 展开更多
关键词 White adipose tissue Subcutaneous adipose tissue Visceral adipose tissue Adipose tissue aging
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Visceral adipose tissue predicts severity and prognosis of acute pancreatitis in obese patients 认领 引用 被引量：5
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作者 Yuan Tian Qing Huang +2 位作者 Yu-Tang Ren Xuan Jiang Bo Jiang 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第5期458-462,共5页
Acute pancreatitis is a common systemic inflammatory disease, manifested by a spectrum of severity, ranging from mild in the majority of patients to severe acute pancreatitis. Patients with severe acute pancreatitis s... Acute pancreatitis is a common systemic inflammatory disease, manifested by a spectrum of severity, ranging from mild in the majority of patients to severe acute pancreatitis. Patients with severe acute pancreatitis suffer from severe local and systemic complications and organ failure, leading to a poor prognosis. The early recognition of the severe condition is important to improve prognosis. Obesity has risen in tandem with an increase in the severity of acute pancreatitis in recent years. Studies have revealed that adipose tissue, particularly visceral adipose tissue is associated with the prognosis of acute pancreatitis. This review discussed the role of visceral adipose tissue in obese patients with acute pancreatitis and explored the possible mechanism involved. 展开更多
关键词 Visceral adipose tissue Obesity Acute pancreatitis
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Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease 认领 引用
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作者 Phillip Gu Shishir Dube +18 位作者 Norman Gellada So Yung Choi Susan Win Yoo Jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres J Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第3期740-750,共11页
BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic ... BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory disease.Unfortunately,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional surgeries.With advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential limitations.Firstly,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after surgery.This strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off therapy.Consequently,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee YJ and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting of manuscript and final approval of manuscript;Melmed GY,Yarur AJ,Fleshner P,Kallman C and Devkota S were involved in study concept and design,data interpretation,drafting of manuscript and final approval of manuscript;Vasiliauskas EA,Bonthala N,Syal G,Ziring D and Targan SR were involved in data interpretation,drafting of manuscript and final approval of manuscript;Rabizadeh S was involved in study concept and design,drafting of manuscript and final approval of manuscript;McGovern DPB was involved in concept and design,statistical analysis,drafting of manuscript and final approval of manuscript. 展开更多
关键词 Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography
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The Importance of Systemic Balance in Safeguarding Health: A Randomized Double-Blind Clinical Trial on VLDL, Triglycerides, Free T3, Leptin, Ghrelin, Cortisol and Visceral Adipose Tissue 认领 引用 被引量：2
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作者 Xanya Sofra 《Health》 2020年第8期1067-1084,共18页
The purpose of this clinical trial was to delineate some of the negative consequences of high BMI on health and explore the possibility of a solution. We analysed the blood test results of nine overweight adults with ... The purpose of this clinical trial was to delineate some of the negative consequences of high BMI on health and explore the possibility of a solution. We analysed the blood test results of nine overweight adults with sedentary lifestyles, and an average BMI of 32.23. Results revealed a statistically significant reduction of visceral adipose tissue, very-low density lipoprotein (VLDL), and triglycerides. Testosterone, leptin, IGF-1 and Free T3 increased within the normal range, juxtaposed by cortisol and ghrelin that declined, but without dipping into abnormality. These findings have important implications during the COVID-19 pandemic, where optimal immunity is deemed necessary in limiting susceptibility to the virus. Recent research indicates that weight gain often escalates vulnerability to respiratory track disturbances, cardiovascular disease (CVD) and diabetes. Consequently, pre-existing conditions increase COVID-19 mortality rates. CVD and diabetes emerge out of hormonal imbalances that involve Free T3, leptin, ghrelin, testosterone, and cortisol. Physical training is decidedly the most acclaimed solution, yet, the least implemented one, due to procrastination, or demoralization after investing constant exhaustive effort with no immediately visible physical change. COVID-19 confinement exacerbates the tendency for inactivity, and promotes stress-eating behaviours. Moreover, strenuous exercise, necessary for visceral fat reduction, results in a negative cortisolestosterone relationship that provokes caloric consumption and inflammation. Offering an alternative to exercise that effectively improves health, boosts metabolism, and controls appetite, may serve as a proactive, and preventive method that can safeguard health. 展开更多
关键词 VLDL Triglycerides Free T3 Leptin Ghrelin Cortisol and Visceral Adipose Tissue COVID-19 Susceptibility
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Critical visceral adipose tissue thresholds aassociated with type 2 diabetes mellitus in chinese population 认领 引用
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作者 Om Kumar Shrestha 《Journal of Nanjing Medical University》 2007年第1期15-20,共6页
To compare intervertebral location L2-L3 with L4-L5 as landmarks for measuring abdominal fat distribution and to determine critical levels of visceral adipose tissue （VAT） at those planes, exceeding which may lead t... To compare intervertebral location L2-L3 with L4-L5 as landmarks for measuring abdominal fat distribution and to determine critical levels of visceral adipose tissue （VAT） at those planes, exceeding which may lead to the development of type 2 diabetes. Methods： Abdominal fat distribution was measured using computed tomography（CT） in 29 diabetics （19 male, 10 female） and 30 non-diabetics （18 male, 12 female）. CT images obtained at two intervertebral locations L2-L3 and L4-L5 were used to measure the areas of total fat, VAT and subcutaneous adipose tissue （SCAT） using slice thickness of 5mm and an attenuation range from -190 to -30 Hounsfield units （HU）. Data were analyzed using logistic regression and Receiver-operating characteristic （ROC） analysis. Results： At L2-L3, diabetes and obesity were correctly classified at 91.53% and 83.05% respectively, while at L4-L5, the same were correctly classified at 84.75% and 88.14% respectively. VAT compared to SCAT, had significantly higher correctly classified percent values for predicting diabetes in both measurement sites. At L2-L3, VAT≥177.29 cm2 or VAT ≥51.52% of the total fat area had the highest correctly classified value for predicting diabetes in men, while VAT ≥ 132.27 cm2 or VAT≥45.7% of the total fat area had the highest correctly classified value for predicting diabetes in women. At LA-L5, VAT≥ 130.82 cm2 or VAT≥45.5,$% of the total fat area had the highest correctly classified value for predicting diabetes in men, while VAT≥ 118.56 cm2 or VAT≥32.24% of the total fat area had the highest correctly classified value for predicting diabetes in women. Conclusion： L2-L3 plane is a better landmark for measuring abdominal fat distribution for predicting diabetes, while abdominal fat distribution measured at L4-L5 has better association with obesity. Regardless of the measurement site, VAT compared to SCAT, has significantly stronger association with diabetes. 展开更多
关键词 visceral adipose tissue type 2 diabetes measurement computed tomography
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Impact of visceral adiposity on glycemic variability in patients with insulin-treated type 2 diabetes undergoing hemodialysis 认领 引用
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作者 Pedro Gil-Millán Ascensión Lupiañez +6 位作者 Sonia Caparrós Alicia Ribas Shaira Martínez-Vaquera Ángel Ortiz-Zuñiga Cristina Hernández Rafael Simó Olga Simó-Servat 《World Journal of Diabetes》 SCIE 2026年第3期151-161,共11页
BACKGROUND Glycemic variability(GV)is increasingly recognized as a major metabolic risk in patients with type 2 diabetes(T2D)undergoing hemodialysis(HD);however,key contributors remain unclear.AIM To identify clinical... BACKGROUND Glycemic variability(GV)is increasingly recognized as a major metabolic risk in patients with type 2 diabetes(T2D)undergoing hemodialysis(HD);however,key contributors remain unclear.AIM To identify clinical predictors of GV–measured by differences in time in range(ΔTIR)–between HD and off-HD days in patients with insulin-treated T2D.METHODS In this prospective study,35 patients with insulin-treated T2D on online HD were monitored using continuous glucose monitoring over 20 days.Glucometric variables included mean glucose,TIR,and glucose management indicator.Patients were stratified byΔTIR into low(5%)fluctuation groups.Body composition was assessed using multifrequency bioelectrical impedance analysis,including visceral fat area(VFA),skeletal muscle index,and extracellular-to-total body water ratio.RESULTS Patients withΔTIR>5%showed higher glucose levels(HD:187.1±44.3 mg/dL;off-HD:201.9±52.3 mg/dL),reduced TIR,elevated glucose management indicator(8.02%±1.14%),and significantly lower VFA(63.4±42.7 cm2 vs 127.0±49.5 cm2;P=0.001).Skeletal muscle index and hydration parameters were not different.VFA independently predictedΔTIR>5%(odds ratio=0.077;P=0.016),and a VFA threshold of approximately 63 cm²yielded 88%sensitivity and 67%specificity(area under the curve of 0.812;P=0.003).CONCLUSION VFA is a strong independent marker of GV in patients with insulin-treated T2D on HD,supporting body composition profiling in this population. 展开更多
关键词 Type 2 diabetes Hemodialysis Visceral adiposity Continuous glucose monitoring Time in range Glycemic stability Body composition Metabolic fragility
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The role of visceral adipose tissue on improvement in insulin sensitivity following Roux-en-Y gastric bypass:a study in Chinese diabetic patients with mild and central obesity 认领 引用 被引量：4
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作者 Lei Zhao Liyong Zhu +5 位作者 Zhihong Su Weizheng Li Pengzhou Li Yong Liu Shengping Liu Shaihong Zhu 《Gastroenterology Report》 SCIE 2018年第4期298-303,I0002,共6页
Background:Most Chinese patients with type 2 diabetes mellitus(T2DM)have mild obesity and central obesity.Central obesity is combined with insulin resistance.The aim of this study was to assess the effect of abdominal... Background:Most Chinese patients with type 2 diabetes mellitus(T2DM)have mild obesity and central obesity.Central obesity is combined with insulin resistance.The aim of this study was to assess the effect of abdominal adipose tissue on insulin-sensitivity improvement after Roux-en-Y gastric bypass(RYGB)in Chinese diabetic patients with mild and central obesity.Methods:Seventeen T2DM patients with a mean body mass index of 30.3 kg/m2 were scheduled for laparoscopic RYGB.A hyperinsulinemic-euglycemic clamp and dual-energy X-ray absorptiometry were performed prior to surgery and 3 months after RYGB.The primary end points were the correlations between insulin sensitivity and abdominal adipose tissue,including visceral adipose tissue(VAT)and subcutaneous adipose tissue(SAT),before and 3 months after RYGB.Results:Indices of peripheral insulin sensitivity,including glucose-disposal rate(M value)and glucose infusion rate,were significantly increased after RYGB.Body-fat mass,VAT and SAT were significantly reduced after RYGB.The pre-operative M value was significantly correlated with VAT mass(r=–0.57,P=0.02),but not correlated with SAT mass.M value changes after RYGB were highly correlated with changes in VAT mass(r=–0.59,P=0.01),percentage of VAT mass(r=–0.66,P<0.01),VAT area(r=–0.56,P=0.02)and percentage of VAT area(r=–0.57,P=0.02).Conclusions:A significant correlation was observed between increased peripheral insulin sensitivity and decreased VAT following RYGB in Chinese patients with mild and central obesity.VAT and SAT were significantly decreased with improved insulin sensitivity after RYGB.VAT mass may be considered as an indication for gastric bypass during patient selection. 展开更多
关键词 Insulin sensitivity visceral adipose tissue gastric bypass hyperinsulinemic-euglycemic clamp type 2 diabetes mellitus non-morbid obesity
Postoperative excessive gain in visceral adipose tissue as well as body mass index are associated with adverse outcomes of an ileal pouch 认领 引用 被引量：2
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作者 Ganglei Liu Xianrui Wu +4 位作者 Yi Li Yuanyi Rui Luca Stocchi Feza HRemzi Bo Shen 《Gastroenterology Report》 SCIE 2017年第1期29-35,I0001,I0002,共7页
Background:There are no published studies on the impact of visceral adipose tissue(VAT)change on outcomes of restorative proctocolectomy and ileal pouch-anal anastomosis(IPAA).The aim of this historic cohort study was... Background:There are no published studies on the impact of visceral adipose tissue(VAT)change on outcomes of restorative proctocolectomy and ileal pouch-anal anastomosis(IPAA).The aim of this historic cohort study was to evaluate the impact of excessive VAT gain on the outcomes of inflammatory bowel disease(IBD)patients with IPAA.Methods:We evaluated all eligible patients with at least two sequential CT scans after pouch construction from our prospectively maintained Pouchitis Registry between 2002 and 2014.The visceral fat area(VFA)was measured on CT images.The study group comprised patients with a significant VAT gain(>15%),and the control group was those without.The adverse outcomes of the pouch were defined as the new development of chronic pouch inflammation(chronic pouchitis,chronic cuffitis or Crohn’s disease of the pouch),anastomotic sinus and the combination of above(the composite adverse outcome)or pouch failure,after the inception CT.Results:Of 1564 patients in the Registry,59(3.8%)with at least 2 CT scans after pouch surgery were included.Twenty-nine patients(49.2%)were in the study group,and 30(50.8%)were in the control group.The median duration from the inception to the latest CT was 552(range:31–2598)days for the entire cohort.We compared the frequency of new chronic pouch inflammation(13.8%vs 3.3%,P=0.195),new pouch sinus(10.3%vs 0%,P=0.112),composite adverse pouch outcome(24.1%vs 3.3%,P=0.026)or pouch failure(10.3%vs 6.7%,P=0.671)between the two groups.Kaplan-Meier plot for time-to-pouch failure between the pouch patients with or without excessive body mass index(BMI)gain(>10%)showed statistical difference(P=0.011).Limited stepwise multivariate analysis showed that excessive VAT gain(odds ratio=12.608,95%confidence interval:1.190–133.538,P=0.035)was an independent risk factor for the adverse pouch comes.Conclusions:In this cohort of ileal pouch patients,excessive VAT gain as well as gain in BMI after pouch construction was found to be associated with poor long-term outcomes. 展开更多
关键词 inflammatory bowel disease ileal pouch pouch failure visceral adipose tissue visceral fat area
Association of visceral adipose tissue with gout:Observational and Mendelian randomization analyses 认领 引用 被引量：1
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作者 Wenze Xiao Qi Wang +2 位作者 Yining Liu Hui Zhang Hejian Zou 《Chinese Medical Journal》 SCIE CAS CSCD 2024年第19期2351-2357,共7页
Background:The causal relationship between visceral adipose tissue(VAT)and gout is still unclear.We aimed to examine the potential association between them using observational and Mendelian randomization(MR)analyses.M... Background:The causal relationship between visceral adipose tissue(VAT)and gout is still unclear.We aimed to examine the potential association between them using observational and Mendelian randomization(MR)analyses.Methods:In the observational analyses,a total of 11,967 participants(aged 39.5±11.5 years)were included from the National Health and Nutrition Examination Survey.Logistic regression models were used to investigate the association between VAT mass and the risk of gout.In two-sample MR analyses,211 VAT mass-related independent genetic variants(derived from genome-wide association studies in 325,153 UK biobank participants)were used as instrumental variables.The random-effects inverse-variance weighted(IVW)method was used as the primary analysis.Additional sensitivity analyses were also performed to validate our results.Results:Observational analyses found that an increase in VAT mass(per standard deviation)was associated with a higher risk of gout after controlling for confounding factors(odds ratio[OR]=1.27,95%confidence intervals[CI]=1.11-1.45).The two-sample MR analyses demonstrated a causal relationship between increased VAT mass and the risk of gout in primary analyses(OR=1.78,95%CI=1.57-2.03).Sensitivity analyses also showed similar findings,including MR-Egger,weighted median,simple mode,weighted mode,and leave-one-out analyses.Conclusions:Observational analyses showed a robust association of VAT mass with the risk of gout.Meanwhile,MR analyses also provided evidence of a causal relationship between them.In summary,our findings suggested that targeted interventions for VAT mass may be beneficial to prevent gout. 展开更多
关键词 Visceral adipose tissue Gout Observational analyses Mendelian randomization Causal relationship Epidemiology
Endocrine-disrupting chemicals in human adipose tissue and associations between exposure and obesity 认领 引用
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作者 Zhenhua Lu Aijing Li +5 位作者 Yue Gao Haowei Shi Xiaolei Shi Weijing Li Jinghai Song Maoyong Song 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2025年第9期552-561,共10页
Bio-accumulation of endocrine-disrupting chemicals(EDCs)in human body may result in various adverse health effects.This study measured the levels of 16 EDCs in the visceral adipose tissue of 55 participants in China a... Bio-accumulation of endocrine-disrupting chemicals(EDCs)in human body may result in various adverse health effects.This study measured the levels of 16 EDCs in the visceral adipose tissue of 55 participants in China and investigated their association with obesity.MeP,BPP,PrP,BPA,EtP,BPE,and BPC were frequently detected in more than 50%of the adipose tissues.A positive correlation between bisphenol A and body mass index(BMI)was observed in both multivariate linear regression model(β=0.87,95%confidence interval:0.21-1.53,p=0.011)and multivariate logistic regression analysis(odds ratio=1.28,95%confidence interval:1.01-1.62,0.044).Restricted cubic spline regression analysis revealed a significant nonlinear association between bisphenol P and BMI.Weighted quantile sum regression and quantile-based g-computation revealed a slight positive trend between EDCs mixed exposure and BMI,with bisphenol A as the primary contributor to the positive correlation with BMI.Our findings suggest the extensive existence of environmental EDCs in the adipose tissue of the adult Chinese population and indicate that exposure to BPA in adipose tissue may be associated with the occurrence of obesity. 展开更多
关键词 Endocrine-disrupting chemicals Mixed exposure Visceral adipose tissue Body-mass index Obesity
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Transcriptional Features of Cattle Visceral and Subcutaneous Adipose Tissues: A Study of RNA-seq 认领 引用
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作者 Xiaoyan Duan Yu Liu +1 位作者 Xiaoxiao Zhang Haiyi Zhao 《Open Journal of Animal Sciences》 2022年第3期441-453,共13页
Visceral and subcutaneous are the two major types of bovine adipose tissues, and they show metabolic and functional differences according to their distribution, exploring the transcriptional features of visceral and s... Visceral and subcutaneous are the two major types of bovine adipose tissues, and they show metabolic and functional differences according to their distribution, exploring the transcriptional features of visceral and subcutaneous adipose tissues is necessary. In the present study, we conducted RNA-seq analysis to compare the transcriptome between visceral (great omental) and subcutaneous (backfat) adipose tissues from Chinese Simmental cattle and validate them by qRT-PCR. We found that 5864 genes were differentially expressed between two tissues, including 2979 up-regulated and 2885 down-regulated in visceral adipose tissue. Functional analysis revealed a variety of differentially expressed genes (DEGs) involved in lipid metabolism and immune response processes. This may provide valuable information to further our understanding of the complexity of gene regulation governing the physiology of different fat depots. This work highlighted potential genes regulating lipid metabolism and immune responses;it may contribute to a better understanding of the metabolic and functional differences between visceral and subcutaneous adipose tissues. 展开更多
关键词 Visceral Adipose Tissue Subcutaneous Adipose Tissue Transcriptional Features Cattle
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Visceral adiposity index and cardiorespiratory fitness:Unmasking risk of impaired fasting glucose among adolescents 认领 引用
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作者 Ravi Shah Rimesh Pal +2 位作者 Juniali Hatwal Akash Batta Bishav Mohan 《World Journal of Clinical Pediatrics》 2025年第2期221-224,共4页
Type 2 diabetes mellitus(T2DM)is increasing among adolescents,but paediatric risk predictors are relatively underdeveloped.This study aimed to establish the associations of visceral adiposity index(VAI)and cardiorespi... Type 2 diabetes mellitus(T2DM)is increasing among adolescents,but paediatric risk predictors are relatively underdeveloped.This study aimed to establish the associations of visceral adiposity index(VAI)and cardiorespiratory fitness(CRF)with fasting plasma glucose in 418 Nigerian adolescents aged 11 years to 19 years.Using a cross-sectional design,participants were stratified by VAI and CRF tertiles to examine variations in impaired fasting glucose(IFG)risk.The findings of this study revealed significant gender differences:In the case of boys,high VAI and low CRF is associated with IFG,while no association was present in girls.CRF,measured by the 20-meter shuttle run,was a stronger predictor of IFG than VAI,suggesting that physical fitness is a protective factor against glucose dysreg-ulation.These findings point to VAI and CRF as useful,non-invasive predictors of risk for T2DM in youth,supporting school-based fitness programs that promote CRF and attenuate visceral adiposity,particularly in males.Future work must validate these predictors across various ethnic populations and identify other risk factors that can augment plans for early interventions aimed at the prevention of adolescent T2DM. 展开更多
关键词 Impaired fasting glucose Visceral adiposity index Cardiorespiratory fitness Adolescents Diabetes mellitus Public health
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Association of obesity-related indices with chronic kidney disease risk in diabetes:A cross-sectional study 认领 引用
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作者 Dong-Ni Huang Qi Pan +2 位作者 Li-Xin Guo Jing Ma Guo-Gang Xu 《World Journal of Diabetes》 SCIE 2026年第5期144-156,共13页
BACKGROUND Chronic kidney disease(CKD)is a major microvascular complication of diabetes and a leading cause of morbidity and mortality.Obesity and visceral fat accumulation contribute to renal dysfunction,but traditio... BACKGROUND Chronic kidney disease(CKD)is a major microvascular complication of diabetes and a leading cause of morbidity and mortality.Obesity and visceral fat accumulation contribute to renal dysfunction,but traditional measures such as body mass index may incompletely reflect metabolism-related harm from adipose tissue.Although numerous adiposity indices have been developed,comparative evidence on their associations with CKD in adults with diabetes remains limited.AIM To compare 10 adiposity indices and evaluate their associations and discriminative abilities for CKD among adults with diabetes.METHODS This retrospective cross-sectional study included 3526 adults with diabetes who underwent health examinations at a tertiary hospital.A total of 10 adiposity indices were calculated.CKD was classified as estimated glomerular filtration rate below 60 mL/min/1.73 m2 and/or an albumin-to-creatinine ratio≥30 mg/g.Multivariable logistic regression estimated odds ratios per standard-deviation increase,with additional adjustment.Restricted cubic splines assessed dose-response patterns,and discrimination was evaluated using the area under the receiver operating characteristic curve.RESULTS Among the 3526 participants,456(12.9%)had CKD.The CKD group had a higher proportion of men(86.0%vs 80.7%,P=0.007)and a higher prevalence of hypertension(62.7%vs 46.4%,P<0.001)compared with the non-CKD group.In both the primary and the comorbidity-adjusted sensitivity models,all examined indices were positively associated with CKD(all P<0.001).Restricted cubic splines analyses showed no evidence of nonlinearity for body mass index,Chinese visceral adiposity index(CVAI),body roundness index,conicity index,and waist-to-height ratio,whereas the other indices showed evidence of nonlinearity(P<0.05).CVAI had the highest area under the curve(0.637),whereas a body shape index had the lowest(0.526).CONCLUSION In adults with diabetes,multiple adiposity indices are associated with CKD.CVAI shows the best discrimination and may aid CKD risk assessment. 展开更多
关键词 Chronic kidney disease Diabetes Obesity-related indices Chinese visceral adiposity index Visceral adiposity
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Estrogen restores disordered lipid metabolism in visceral fat of prediabetic mice 认领 引用 被引量：1
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作者 Su-Huan Liu Zhao-Shui Shangguan +3 位作者 Paiziliya Maitiaximu Zhi-Peng Li Xin-Xin Chen Can-Dong Li 《World Journal of Diabetes》 SCIE 2024年第5期988-1000,共13页
BACKGROUND Visceral obesity is increasingly prevalent among adolescents and young adults and is commonly recognized as a risk factor for type 2 diabetes.Estrogen[17β-estradiol(E2)]is known to offer protection against... BACKGROUND Visceral obesity is increasingly prevalent among adolescents and young adults and is commonly recognized as a risk factor for type 2 diabetes.Estrogen[17β-estradiol(E2)]is known to offer protection against obesity via diverse me-chanisms,while its specific effects on visceral adipose tissue(VAT)remain to be fully elucidated.AIM To investigate the impact of E2 on the gene expression profile within VAT of a mouse model of prediabetes.METHODS Metabolic parameters were collected,encompassing body weight,weights of visceral and subcutaneous adipose tissues(VAT and SAT),random blood glucose levels,glucose tolerance,insulin tolerance,and overall body composition.The gene expression profiles of VAT were quantified utilizing the Whole Mouse Genome Oligo Microarray and subsequently analyzed through Agilent Feature Extraction software.Functional and pathway analyses were conducted employing Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses,respectively.RESULTS Feeding a high-fat diet(HFD)moderately increased the weights of both VAT and SAT,but this increase was mitigated by the protective effect of endogenous E2.Conversely,ovariectomy(OVX)led to a significant increase in VAT weight and the VAT/SAT weight ratio,and this increase was also reversed with E2 treatment.Notably,OVX diminished the expression of genes involved in lipid metabolism compared to HFD feeding alone,signaling a widespread reduction in lipid metabolic activity,which was completely counteracted by E2 adminis-tration.This study provides a comprehensive insight into E2's local and direct protective effects against visceral adiposity in VAT at the gene level.CONCLUSION In conclusion,the present study demonstrated that the HFD-induced over-nutritional challenge disrupted the gene expression profile of visceral fat,leading to a universally decreased lipid metabolic status in E2 deficient mice.E2 treatment effectively reversed this condition,shedding light on the mechanistic role and therapeutic potential of E2 in combating visceral obesity. 展开更多
关键词 Estrogen Obesity,Visceral adiposity Energy metabolism Type 2 diabetes
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The Danger within:Covid-19 Affinity for ACE2 Receptors in Adipose Tissue and Testes.The Protective Effects of Estradiol,Fitness,and Weight Management 认领 引用
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作者 Xanya Sofra 《Journal of Endocrinology Research》 CAS 2020年第1期1-14,共14页
The imminent danger of the Covid-19 pandemic has accelerated research in pharmaceuticals that either target the viral Spike proteins fusion with ACE2 receptors,or the infectious RNA replication that often overwhelms i... The imminent danger of the Covid-19 pandemic has accelerated research in pharmaceuticals that either target the viral Spike proteins fusion with ACE2 receptors,or the infectious RNA replication that often overwhelms immune defences.The scope of this review was to elucidate the main human vulnerabilities to Covid-19,including the accumulation of ACE2 receptors in testes,adipose tissue,thyroid,heart and kidneys that escalate viral affinity in males,the aged,and certain medical conditions,including diabetes,CVD,and pulmonary diseases.Pre-existing inflammation inherent in obesity may exacerbate the“cytokine storm,”a rampaging immune reaction during the course of Covid-19 that is deleterious to the host.We examined the molecular dynamics illustrating the action of new therapeutics necessary for Covid-19 patients;the estradiol advantage hypothesis;alternative therapies including hormone replacement procedures and mesenchymal stem cells;plus preventive and protective interventions.The current perspective also explored the primary components of dysregulated health predisposing individuals to Covid-19,including hormonal imbalance,increased lipids and lipoproteins,thyroid dysfunction,degraded fitness,and age-related testosterone decline accompanied by cortisol increase that provokes stress eating behaviours and weight accumulation.Obesity increases the probability of Covid-19 infection due to its abundance of ACE2 receptors;while physical activity may decrease Covid-19 vulnerability,by reducing fat and increasing muscle mass that manifests a relatively inhibited ACE2 expression.Several weight management solutions feature lasers and radiofrequency which diminish subcutaneous adiposity but do not enhance fitness.A data metanalysis of seven recently published clinical studies on 95 obese individuals,73 males and 22 females with an average BMI of 30.9,demonstrated visceral fat reduction combined with increased skeletal muscle mass.It also revealed a statistically significant decrease in BMI,lipids,lipoproteins,inflammation and toxicity as measured by CRP,Creatinine and Bilirubin respectively,juxtaposed by optimally healthier levels of Cortisol,Testosterone,Free T3,IGF-1,Insulin,and the appetite controlling hormones Leptin and Ghrelin. 展开更多
关键词 Visceral Adipose Tissue ACE2 Testes Covid-19 Estradiol Fitness Weight management Leptin Free T3 Testosterone BMI BMR VLDL Triglycerides HDL Creatinine Bilirubin Ghrelin Insulin IGF-1 Cortisol CRP Diabetes Prediabetes Hyperphagia
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Low skeletal muscle mass and high visceral adiposity are associated with recurrence of acute cholecystitis after conservative management:A propensity score-matched cohort study 认领 引用
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作者 Yudai Koya Michihiko Shibata +5 位作者 Yuki Maruno Yoshitaka Sakamoto Shinji Oe Koichiro Miyagawa Yuichi Honma Masaru Harada 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第1期64-70,共7页
Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of AC.Low skeletal muscle mass or adiposity hav... Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of AC.Low skeletal muscle mass or adiposity have various effects in several diseases.We aimed to clarify the relationship between RAC and body parameters.Methods:Patients with AC who were treated at our hospital between January 2011 and March 2022 were enrolled.The psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of AC.The areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI groups.We performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of RAC.Results:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)groups.In the propensity score-matched cohort there were 57 patients in each group.In Kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95%confidence interval 1.083-25.450,P=0.039)and 0.158(95%confidence interval:0.026-0.937,P=0.042),respectively.Conclusions:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC. 展开更多
关键词 Acute cholecystitis Low skeletal muscle mass Recurrent acute cholecystitis Sarcopenia Visceral adiposity
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Association between Chinese visceral adiposity index and risk of cardiometabolic multimorbidity in middle-aged and elderly Chinese population:Evidence from a national longitudinal study 认领 引用
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作者 卢晓琪 杨富丽 曾平 《South China Journal of Cardiology》 CAS 2024年第2期76-88,98,共13页
Background There are several surrogate indicators of abdominal fat deposition,including tri-ponderal mass index(TMI),lipid accumulation product(LAP),and the Chinese visceral adiposity index(CVAI).In spite of this,it r... Background There are several surrogate indicators of abdominal fat deposition,including tri-ponderal mass index(TMI),lipid accumulation product(LAP),and the Chinese visceral adiposity index(CVAI).In spite of this,it remains unclear whether these indices have a longitudinal relationship with the prevalence of cardiometabolic multimorbidity(CM),a pressing global health issue.This research investigated the association between CVAI and CM compared to other indicators of visceral obesity.Methods 6638 participants(aged>45)from the China Health and Retirement Longitudinal Study(CHARLS)were analyzed for incident CM.Cox proportional models were adopted to explore whether the level of CVAI was correlated with the risk of CM.Harrell's concordance statistic(C-statistic)was applied to compare predictive values.Sensitivity and subgroup analyses were implemented for the steadiness of the results.Results Over 4 years,266(4.01%)participants developed CM.A 1-standard deviation(SD)increase in the levels of CVAI,body mass index(BMI),LAP,and TMI was associated with greater CM risk after adjusting for confounders[hazard ratios(HRs):2.20,95%confidence interval(CI):1.88-2.57,1.92(95%CI:1.55-2.38),1.20(95%CI:1.12-1.27),and 1.50(95%CI:1.35-1.66),respectively].CVAI outperformed other indices in predictive performance.Subgroup analysis revealed younger participants or those living alone were more prone to developing CM.Results were potent after finishing all sensitivity analyses.Conclusions The study highlighted a positive correlation between the level of CVAI and CM risk.CVAI's superior predictive performance positions it as a reliable indicator for identifying individuals at heightened CM risk. 展开更多
关键词 China Health and Retirement Longitudinal Study(CHARLS) Cardiometabolic multimorbidity Chinese visceral adiposity index Abdominal obesity Lipid accumulation product Tri-ponderal mass index
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The Association of Visceral Adiposity Index with Insulin Resistance in Adults with Prediabetes 认领 引用 被引量：1
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作者 Md. Shahed-Morshed Tahniyah Haq +4 位作者 Md. Fariduddin Sultana Parveen Tohfa-E-Ayub Naureen Mahbub M. A. Hasanat 《Open Journal of Endocrine and Metabolic Diseases》 2021年第1期12-23,共12页
Visceral adiposity mediates insulin resistance, but their association among adults with prediabetes is scarce in the literature. This study is aimed to determine the association of visceral adiposity index (VAI) with ... Visceral adiposity mediates insulin resistance, but their association among adults with prediabetes is scarce in the literature. This study is aimed to determine the association of visceral adiposity index (VAI) with insulin resistance in adults with prediabetes. This cross-sectional study was done among 117 adults with newly detected prediabetes [m/f;23/94;mean ± SD: Age 36.30 ± 9.99 years, BMI 28.89 ± 4.35 kg/m2] based on American Diabetes Association 2018 criteria and 141 matched healthy controls [m/f: 28/113;mean ± SD: 35.30 ± 6.88 years, BMI 25.03 ± 4.58]. Waist circumference, body mass index, fasting triglyceride, HDL cholesterol, fasting blood glucose and insulin were measured in each group to calculate VAI and homeostatic model assessment of insulin resistance (HOMA-IR). People with prediabetes had significantly higher median value of VAI {3.08 (2.26) vs. 1.86 (2.31);p 1) (98.3% vs. 85.8%;p 展开更多
关键词 Visceral Adiposity Index Insulin Resistance Prediabetes Homeostatic Model Assessment of Insulin Resistance
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Novel approach to risk stratification:Integrating waist-hip ratio for predicting advanced colorectal neoplasia 认领 引用 被引量：1
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作者 Arvind Mukundan Devansh Gupta +1 位作者 Riya Karmakar Hsiang-Chen Wang 《World Journal of Clinical Oncology》 2025年第10期9-13,共5页
The urgent necessity for enhanced risk stratification to improve the efficiency of colonoscopy screening is underscored by the fact that colorectal cancer(CRC)continues to be a primary cause of global cancer mortality... The urgent necessity for enhanced risk stratification to improve the efficiency of colonoscopy screening is underscored by the fact that colorectal cancer(CRC)continues to be a primary cause of global cancer mortality.Conventional models mostly rely on generalized obesity markers including body mass index(BMI),which does not effectively represent oncogenic risk linked with abdominal obesity.Liu et al undertook a large-scale case-control study comprising 6484 firsttime colonoscopy patients at a prominent Chinese hospital between 2020 and 2023 to overcome this restriction.Age,male sex,smoking status,and raised waist-hip ratio(WHR)were found by multivariate logistic regression as independent predictors of advanced colorectal neoplasia(ACN).In a validation cohort of 1891 individuals,a new 7-point risk scoring model was created and stratified into low-(5.0%)ACN prevalence,moderate-(10.3%)and high-risk(17.6%).With C-statistic=0.66 the model showed better discriminating ability than the Asia-Pacific Colorectal Screening(APCS)score(C-statistic=0.63)and the BMI-modified APCS model.These results fit newly published data showing central obesity as a major carcinogenic driver via pro-inflammatory visceral adipokine channels.With the use of WHR,patient risk classification is greatly improved,providing a practical tool to make the most of screening resources in the face of rising CRC incidence rates.Finally,multi-ethnic validation is necessary for the WHR-based scoring model to be considered for integration into global CRC preventive frameworks,since it improves the accuracy of ACN risk prediction. 展开更多
关键词 Colorectal cancer Advanced colorectal neoplasia Risk prediction model Waist-hip ratio Central obesity Colonoscopy screening Cancer risk stratification Visceral adiposity Predictive analytics Precision oncology
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Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model 认领 引用 被引量：3
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作者 Fateheya Mohamed Metwally Hend Mohamed Rashad +3 位作者 Hanaa Hamdy Ahmed Asmaa Ahmed Mahmoud Ehab Ragaa Abdol Raouf Aboelfetoh Mohamed Abdalla 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2017年第3期214-221,共8页
Objective: To elucidate the molecular mechanisms of the potent anti-obesity effect of Moringa oleifera Lam.(M. oleifera) ethanolic extract and to clarify the link between these mechanisms and the associated metabolic ... Objective: To elucidate the molecular mechanisms of the potent anti-obesity effect of Moringa oleifera Lam.(M. oleifera) ethanolic extract and to clarify the link between these mechanisms and the associated metabolic and vascular risks in the experimental model of visceral obesity.Methods: M. oleifera ethanolic extract was orally administered at 600 mg/kg body weight in obese female rats daily for 12 weeks. At the end of treatment, body weight was determined, and the atherogenic index, coronary artery index, glucose level, insulin resistance status, liver and kidney functions were assessed. Also, the m RNA of leptin, adiponectin and resistin in visceral adipose tissue was determined by quantitative real time-PCR.Results: The results showed that M. oleifera extract down-regulated m RNA expression of leptin and resistin, while it up-regulated adiponectin gene expression in obese rats relative to untreated obese control counterparts. This amelioration of genes expression was paralleled by a reduction in body weight and improvement of the atherogenic index and coronary artery index, as well as glucose level and insulin resistance value without adverse effects on liver or kidney functions, versus the untreated obese control ones.Conclusions: It is reasonable to assume that the anti-obesity, anti-atherogenic and antidiabetic properties of M. oleifera are mechanistically achieved via working directly on the adipokines of the visceral adipose tissue. Therefore, M. oleifera may be a good therapeutic candidate for the symptoms of metabolic syndrome. 展开更多
关键词 Moringa oleifera Lam Visceral adipose tissue Adipokines Gene expression Rats
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