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Visual functioning in patients with macular degeneration compared to patients with cataracts 认领 引用
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作者 Reilley M.Knott Nathan Grove +3 位作者 Jennifer L.Patnaik Niranjan Manoharan Anne M.Lynch Karen L.Christopher 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第7期1278-1283,共6页
●AIM:To compare Visual Functioning Questionnaire-25(VFQ)response data in patients with age-related macular degeneration(AMD)to patients with cataracts.●METHODS:In total 415 individuals with early or intermediate AMD... ●AIM:To compare Visual Functioning Questionnaire-25(VFQ)response data in patients with age-related macular degeneration(AMD)to patients with cataracts.●METHODS:In total 415 individuals with early or intermediate AMD and 236 patients with visually significant cataracts who completed the VFQ-25 from a single academic eye center registry between July 2014 and May 2022 were identified.The effect of disease(AMD versus cataract)on VFQ composite score was analyzed using univariate and multivariable linear regression,controlling for age,race/ethnicity,history of transient ischemic attack(TIA)/stroke,and visual acuity.●RESULTS:AMD patients were older than the cataract group(76.0±7.4y vs 73.2±5.9y,P<0.001).There was no difference in sex between groups with both being predominantly female(63%for AMD vs 61%for cataracts,P=0.801).The VFQ composite score was higher in the AMD group(88.8±10.7 vs 82.8±14.5,P<0.001).All vision-related and socio-emotional subscales had significantly higher scores among AMD compared to cataract patients.When adjusted for age,race/ethnicity,history of TIA/stroke,bettereye visual acuity,and worse-eye visual acuity,patients with cataracts had a 3.3-point lower VFQ composite score(95%CI:-5.3 to-1.4,P<0.001)compared to patients with AMD.●CONCLUSION:Patients with early or intermediate AMD report higher visual functioning compared to patients with cataracts in composite score and all VFQ subscale categories in both unadjusted and adjusted analyses. 展开更多
关键词 Visual Functioning Questionnaire agerelated macular degeneration visual acuity cataract surgery
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Visual function and vision-related quality of life after vitrectomy for idiopathic macular hole: a 12mo followup study 认领 引用 被引量：6
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作者 Hong-Tao Duan Song Chen +2 位作者 Yue-Xin Wang Jia-Hui Kong Meng Dong 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2015年第4期764-769,共6页
· AIM: To investigate the visual function and the relationship with vision-related quality of life(VRQOL)after macular hole repair surgery.· METHODS: Prospective case series. Thirty-six consecutive eyes in 3... · AIM: To investigate the visual function and the relationship with vision-related quality of life(VRQOL)after macular hole repair surgery.· METHODS: Prospective case series. Thirty-six consecutive eyes in 36 patients who underwent pars plana vitrectomy(PPV) and internal limiting membrane(ILM) peeling were included. The 25-item National Eye Institute Visual Function Questionnaire(VFQ-25) was answered by the participants before and 3 and 12 mo after operation. Follow-up visits examinations included best-corrected visual acuity(BCVA), clinical examination,and central macular thickness(CMT) measured by optical coherence tomography(OCT).·RESULTS: Macular-hole closure was achieved in 35 of36 eyes(97.2%). At baseline and months 3 and 12, the log MAR BCVAs(mean±SD) were 1.15±0.47, 0.68±0.53(P 【0.0001 versus baseline), and 0.55 ±0.49(P 【0.001 versus baseline, P =0.273 versus month 3), respectively; the CMTs(μm) were 330 ±81, 244 ±62(P 【0.001 versus baseline), and 225±58(P 【0.001 versus baseline, P =0.222 versus month 3), respectively; the median preoperative VFQ-25 composite score of 73.50(63.92-81.13) increased postoperatively to 85.50(80.04-89.63) at 3mo(P 【0.001)and 86.73(82.50-89.63) at 12mo(P 【0.001) respectively.The improved BCVA was correlated with improvements in five subscales(r =-0.605 to-0.336, P 【0.001 to P =0.046) at 12 mo.· CONCLUSION: PPV with ILM peeling improved anatomic outcome, visual function, and VRQOL. Theimproved BCVA was an important factor related to the improved VRQOL. 展开更多
关键词 idiopathic macular hole vitrectomy quality of life National Eye Institute Visual Function Questionnaire
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Visual function alterations in cavernous hemangioma of the orbital apex after surgery 认领 引用 被引量：5
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作者 Kang Xue Min Wang Jiang Qian 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2016年第10期1528-1531,共4页
Dear Editor,I am Dr.Kang Xue,from the Department of Ophthalmology at the Eye,Ear,Nose and Throat Hospital of Fudan University in Shanghai,China.I am writing to present three case reports of the removal of visual funct... Dear Editor,I am Dr.Kang Xue,from the Department of Ophthalmology at the Eye,Ear,Nose and Throat Hospital of Fudan University in Shanghai,China.I am writing to present three case reports of the removal of visual function alterations in cavernous hemangioma of the orbital apex after surgery.Cavernous hemangioma is a relatively common primary benign orbital tumor in adults. 展开更多
关键词 Visual function alterations in cavernous hemangioma of the orbital apex after surgery VEP
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The Study of Relationships between the Damage of Visual Function and Hemorrheology, Ocular Rheography, as well as Other Related Factors in Patients with Primary Open Angle Glaucoma (POAG) 认领 引用 被引量：1
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作者 Jian Ge, Wenbing Zhou National Ophthalmological Laboratories, Ministry of Public Health, China, Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Sciences, Guangzhou 510060, China Jiancu Zhu, Anheng Cheng, Yulan Lin, Hongyan Tong, Lin Lian, Zhixing Chen Institute of Cardiovascular Diseases of Guangdong Province, Guangzhou 510080, China 《眼科学报》 CAS 1993年第1期3-11,共9页
Researches of glaucoma visual function damage, hemorrheololgy, ocular rheography and other related multiplex factors, with computed multifactorial stepwise regresion analysis, indicate that the elevation of intraocula... Researches of glaucoma visual function damage, hemorrheololgy, ocular rheography and other related multiplex factors, with computed multifactorial stepwise regresion analysis, indicate that the elevation of intraocular pressure (IOP) is not the only factor to induce visual impairment. POAG patients are shown to have markedly reduced diastolic purfussion pressure in ophthalmic artery, besides prolonged filling time of the retinal artery and vein, diminished erythrocyte deformability and increased platele... 展开更多
关键词 visual function hemorrheology primary open angle glaucoma (POAG) ocular rehography intraocular pressure (IOP) blood cells trace elements multiphy stepwise regression.
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Frequency cumulative effect of subthreshold energy laser-activated remote phosphors irradiation on visual function in guinea pigs 认领 引用
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作者 Yu-Fei Zhang Xiao-Hong Zhou +6 位作者 Rui-Dan Cao Jun-Bo Song Dong-Yu Wei Fu-Jun Duan Wei Wang Zuo-Ming Zhang Tao Chen 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2022年第2期213-220,共8页
AIM:To explore the effects of laser-activated remote phosphors(LARP)on visual function in guinea pigs.METHODS:Electroretinogram(ERG)of guinea pigs were observed after LARP irradiation at different frequencies and irra... AIM:To explore the effects of laser-activated remote phosphors(LARP)on visual function in guinea pigs.METHODS:Electroretinogram(ERG)of guinea pigs were observed after LARP irradiation at different frequencies and irradiation times.We evaluated the expression of rhodopsin,β-catenin,connexin36,calretinin,and calbindin in the retina of guinea pigs and measured the density of photoreceptor cells after high-frequency LARP irradiation.RESULTS:After LARP irradiation,the ERG results showed that the amplitude of the dark-adapted 3.0 b-wave of the model eye was lower than that of the control eye after high-frequency irradiation(P<0.05).The expression of rhodopsin,β-catenin,connexin36,calretinin,and calbindin in the retina of guinea pig declined.CONCLUSION:There is frequency cumulative damage effect on the retina that relates to LARP illumination frequency.This has significance for staff visual protection policies under LARP lighting conditions. 展开更多
关键词 irradiation visual function visual protection retina
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THE SIGNIFICANCE OF TESTING PREOPERATIVE VISUAL FUNCTION IN CATARACT USING LASER INTERFEROMETRIC VISUAL ACUITY AND ERG 认领 引用 被引量：2
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作者 De-Zheng Wu Lezheng Wu Xijing Xu Hui Chen Taiqing Luo Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou 510060, China 《眼科学报》 CAS 1991年第1期21-24,共4页
Tests of preoperative visual function and prediction of postoperative E chart visual acuity(ECVA) using laser interferometric visual acuity(LIVA) and electroretinogram(ERG) were performed in 16 cases(19 eyes) of catar... Tests of preoperative visual function and prediction of postoperative E chart visual acuity(ECVA) using laser interferometric visual acuity(LIVA) and electroretinogram(ERG) were performed in 16 cases(19 eyes) of cataract. The results showed that the coincident rate between preoperative LIVA and postoperative ECVA was 63.2%, and there was a parallel correlation between preoperative amplitude of photopic ERG b-wave and postoperative ECVA in 79.0% of the eyes. Comparing these two methods, the test of LIVA ... 展开更多
关键词 THE SIGNIFICANCE OF TESTING PREOPERATIVE VISUAL FUNCTION IN CATARACT USING LASER INTERFEROMETRIC VISUAL ACUITY AND ERG
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Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt 认领 引用 被引量：9
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作者 Nizar Saleh Abdelfattah Mohamed Amgad +14 位作者 Ahmed A Salama Marina E Israel Ghada A Elhawary Ahmed E Radwan Mohamed M Elgayar Tamer M EL Nakhal Islam T Elkhateb Heba A Hashem Doha K Embaby Amira A Elabd Reem K Elwy Magdi S Yacoub Hamdy Salem Mohamed Abdel-Baqy Ahmad Kassem 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2014年第5期891-897,共7页
AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines.We enrolled ad... AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines.We enrolled adult consenting patients with bilateral chronic eye diseases who presented to 14 hospitals across Egypt from October to December 2012,and documented their clinical findings.Psychometric properties were then tested using STATA.RESULTS:We recruited 379 patients,whose mean age was(54.5±15)y.Of 46.2%were males,227 had cataract,31 had glaucoma,23 had retinal detachment,37 had diabetic retinopathy,and 61 had miscellaneous visual defects.Non-response rate and the floor and ceiling numbers of the Arabic version(ARB-VFQ-25)were calculated.Internal consistency was high in all subscales(except general health),with Cronbach-αranging from0.702-0.911.Test-retest reliability was high(intraclass correlation coefficient 0.79).CONCLUSION:RB-VFQ-25 isareliableandvalidtool for assessing visual functions of Arabic speaking patients.However,some questions had high non-response rates and should be substituted by available alternatives.Our results support the importance of including self-reported visual functions as part of routine ophthalmologic examination. 展开更多
关键词 Arabic psychometrics questionnaires National Institutes of Health visual function questionnaire
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Effect of visual perception training on binocular visual function reconstruction in patients after strabismus surgery 认领 引用 被引量：12
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作者 Yu Su Fei Wang +1 位作者 Tao Wang Qin-Mei Wang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第10期1657-1661,共5页
AIM:To explore the effect of visual perception learning software training(VPT)on binocular visual function reconstruction in children with intermittent exotropia after strabismus surgery.METHODS:Ninety children with i... AIM:To explore the effect of visual perception learning software training(VPT)on binocular visual function reconstruction in children with intermittent exotropia after strabismus surgery.METHODS:Ninety children with intermittent exotropia admitted to our hospital from June 2018 to December 2018 were included,and randomly divided into VPT and control groups.Children in the control group received basic binocular vision training,while those in the VPT group received VPT after strabismus surgery.Tertiary visual function,visual perception function,Newcastle Control Score(NCS),and ocular position retraction rate were compared at 3 and 12mo after the surgery.RESULTS:At 3 and 12mo after the surgery,the proportion of simultaneous perception,binocular fusion version and binocular stereo vision in the VPT group was conspicuously higher than that in the control group(P<0.05).After the vision training,the binocular visual perception functions of children in both groups were significantly improved compared with that before training(P<0.05).Interestingly,the grating sharpness,texture perception and texture motion perception in the VPT group were dramatically better than control group(P<0.01).The NCS in the VPT group was significantly lower than that in the control group(P<0.05).The ocular position retraction rate in the VPT group was significantly lower than that in the control group at 12mo(8.89%vs 26.67%,P=0.03).CONCLUSION:VPT effectively promotes binocular visual function reconstruction in intermittent exotropia children after strabismus surgery and reduces the strabismus severity and ocular position retraction rate. 展开更多
关键词 children intermittent exotropia visual perception training ocular position binocular visual function
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Effect of changing mesopic and photopic light conditions on visual functions 认领 引用
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作者 Fatemeh Mosayebi Seyyed Mehdi Tabatabaee +1 位作者 Haleh Kangari Saeed Rahmani 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第8期1287-1292,共6页
AIM:To determine the effects of change in light conditions on refractive error and visual functions including visual acuity,stereopsis and contrast sensitivity.METHODS:This cross-sectional study was conducted in the o... AIM:To determine the effects of change in light conditions on refractive error and visual functions including visual acuity,stereopsis and contrast sensitivity.METHODS:This cross-sectional study was conducted in the optometry clinic of the Shahid Beheshti School of Rehabilitation on 48 students in 2021-2022.All of them had eye health and normal visual function and could have refractive errors or not.Light intensity of 4 lx was considered equivalent to photopic light condition and light intensity of 1 lx was considered to be equivalent to mesopic light condition.The amount of refractive error was checked by auto refractometer and its changes in mesopic light condition were subjectively measured.Also,visual acuity,stereopsis and contrast sensitivity(in five spatial frequencies of 1.5,3,6,12,and 18 cycles per degree),were measured first in photopic light condition and then in mesopic light condition,by Snellen control vision chart,stereo butterfly test and the M&S technology monitor test respectively.RESULTS:In the 48 student subjects with an average age of 22.69±3.56y,mean of refractive error as sphere equivalent,visual acuity and stereopsis were-1.25±1.74 diopters,0 logMAR,44.37±13.03 seconds of arc,respectively in photopic light condition while in mesopic light was equal to-1.56±1.75 diopters,0.12±0.09 logMAR and 50.62±33.35 seconds of arc,respectively.The mean of contrast sensitivity measured at spatial frequencies of 1.5,3,6,12,and 18 cycles per degree in photopic condition was equal to 2.38±0.04,2.37±0.07,2.04±0.21,1.27±0.32,0.82±0.27 logarithm of contrast sensitivity,respectively and in mesopic lighting condition was equal to 2.34±0.12,2.30±0.16,1.84±0.28,1.02±0.28,0.63±0.24 logarithm of contrast sensitivity,respectively.Statistical analysis showed a significant difference between the two lighting conditions in all evaluated variables[refractive error(P<0.001),visual acuity(P<0.001),stereopsis(P=0.008)and contrast sensitivity(P<0.001)].CONCLUSION:The refractive error of the student subjects in mesopic light condition change towards myopia,and its amount is clinically significant.Also,the examination and comparison of the factors of visual acuity,stereopsis and contrast sensitivity in these two lighting conditions show that the decrease in brightness level to the mesopic level causes a decrease in the aforementioned visual functions. 展开更多
关键词 mesopic light condition photopic light condition visual performance visual acuity stereopsis contrast sensitivity visual functions
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AB006.Longitudinal effects of an optic nerve injury on behavioural measures of visual functions 认领 引用
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作者 Jacqueline Higgins Jérôme Anton Elvire Vaucher 《Annals of Eye Science》 2019年第1期181-181,共1页
Background:Visual deficits,caused by ocular disease or trauma,can cause lasting damage.However,recent research has focused on neural plasticity as a means to regain visual functions.In order to better understand the i... Background:Visual deficits,caused by ocular disease or trauma,can cause lasting damage.However,recent research has focused on neural plasticity as a means to regain visual functions.In order to better understand the involvement of neural plasticity and reorganization in partial vision restoration,we aim to evaluate the partial recovery of a visual deficit over time using two behavioural tests.In our study,a partial optic nerve crush(pONC)serves as an induced visual deficit,allowing for residual vision from surviving cells.Methods:Visual functions in C57BL/6 mice was measured using two behavioural tests prior to a bilateral pONC,then at various time points after the pONC.In this study,two injury intensities were used:a high intensity pONC with the full force of self-closing forceps,and a low intensity pONC,in which a calibrated space was left between the forceps at the closed position.The two behavioural tests consisted of the optomotor reflex(OMR)and the visual cliff(VC)tests.The OMR test measures the mouse’s tracking reflex in response to moving sinusoidal gratings.The VC test,on the other hand,evaluates exploratory behaviour,by simulating a cliff to observe the animal’s sense of depth perception.After the behavioural evaluation,surviving retinal ganglion cells were counted.Results:The high intensity pONC resulted in a total loss of visual acuity as measured by the OMR test,with no improvement in the following 4 weeks.However,the light intensity pONC showed the same initial loss,but recovery was observed as of day 3,and results in 40-60%recovery after 4 weeks.With the VC test,mice with intact vision will avoid the deep end,opting to spend more time in the shallow end.However,after both high and low intensity pONCs,this preference is no longer observed.Both groups show a return to the shallow end preference at day 14,though the low intensity pONC group showed a stronger preference similar to baseline performance.The percentage of surviving retinal ganglion cells was higher with the low intensity(68%)than with the high intensity(17%)pONC.Conclusions:There is evidence of visual recovery at the behavioural level following a pONC,though very little recovery was observed following a high intensity pONC,and only with the VC test.Therefore,a certain amount of residual retinal input may be required for recovery at the behavioural level. 展开更多
关键词 Optic nerve injury plasticity behaviour visual function
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AB088.Quality of life and visual function in patients with Boston type I keratoprosthesis 认领 引用
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作者 Cristina Bostan Marwan Elfekhfakh Mona Harissi-Dagher 《Annals of Eye Science》 2018年第1期494-494,共1页
Background:To determine patient-reported vision-related quality of life(VR-QoL)following Boston type I keratoprosthesis(BI-KPro)surgery and its association with postoperative best-corrected visual acuity(BCVA).Methods... Background:To determine patient-reported vision-related quality of life(VR-QoL)following Boston type I keratoprosthesis(BI-KPro)surgery and its association with postoperative best-corrected visual acuity(BCVA).Methods:Descriptive cross-sectional study.Consecutive consenting patients with BI-KPro were included.The French National Eye Institute Visual Function Questionnaire-25 administered at 51±18 months postoperatively measured VR-QoL.Clinical charts were reviewed for demographics,indications for BI-KPro,baseline and postoperative(at time of interview)BCVA.For patients operated unilaterally,stratification of VR-QoL scores based on BCVA in the non-operated eye was performed.Multivariate linear regression was carried out,using VR-QoL scores as dependent variables,and demographics and postoperative BCVA as covariates.For patients operated bilaterally,Spearman correlation between VR-QoL scores and BCVA was performed.P20/200 compared to 20/200(P=0.000).BCVA in the non-operated eye was positively associated with all subscales(P<0.01)independently of age,sex,follow-up duration and postoperative BCVA in the operated eye.In patients with bilateral BI-KPro(n=12)the VR-QoL overall score was 63.0±18.7.BCVA in the best eye positively correlated with Near/Distance activities,and social functioning subscales(P<0.05).There was no significant difference between VR-QoL scores of patients operated unilaterally vs.bilaterally.Conclusions:We describe VR-QoL more than 4 years after BI-KPro surgery.Compared to data at 1 year previously reported,our results suggest that,as vision progressively deteriorates in the operated eye,patients increasingly rely on their non-operated eye.VR-QoL after bilateral BI-KPro is assessed for the first time,and appears comparable to that after unilateral surgery.Larger,prospective,long-term studies,with assessment at baseline,are warranted. 展开更多
关键词 Boston type I keratoprosthesis(BI-KPro) National Eye Institute Visual Function Questionnaire-25 vision-related quality of life(VR-QoL)
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Evaluation on the Effect of TCM Syndrome Differentiation Nursing on Visual Function and Intraocular Pressure of Patients after Glaucoma Operation 认领 引用
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作者 LIJun ZHANGTianlan DUSha 《外文科技期刊数据库（文摘版）医药卫生》 2022年第8期133-136,共4页
Objective: to evaluate the effect of applying TCM nursing plan based on syndrome differentiation after surgical treatment of glaucoma patients and its effect and influence on improvement of intraocular pressure and vi... Objective: to evaluate the effect of applying TCM nursing plan based on syndrome differentiation after surgical treatment of glaucoma patients and its effect and influence on improvement of intraocular pressure and visual function. Methods: eighty-four patients with glaucoma who underwent surgery in our hospital were selected for research. The patients time was 2021.2-2022.2. The patients were randomly divided into reference group and experimental group with 42 cases/group. After surgery, the patients in the reference group were treated with ordinary care. On this basis, the patients in the experimental group were treated with TCM nursing based on syndrome differentiation. The improvement of intraocular pressure, visual function, pain degree, postoperative complications and patient satisfaction of the patients in the two groups were discussed. Results: the clinical effects of the two groups of patients were discussed and observed. Compared with the reference group, the experimental group had lower intraocular pressure at night and during the day after intervention, higher visual function index, lower pain score, fewer postoperative complications and higher total patient satisfaction. The data comparison between the two groups showed that the difference between the two groups had statistical significance. Conclusion: when the ordinary care method is used to intervene the patients after glaucoma surgery, the implementation of the TCM nursing scheme based on differentiation of symptoms and signs can ensure the curative effect of the clinical surgery, promote the improvement of the patients intraocular pressure and visual function, reduce the possibility of postoperative complications, and reduce the postoperative pain of the patients. It is a nursing scheme with high patient satisfaction. 展开更多
关键词 satisfaction complications glaucoma visual function TCM syndrome differentiation care
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Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes 认领 引用 被引量：4
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作者 Yu-Qi Shao Yong-Chen Wang +6 位作者 Lu Wang Hang-Ze Ruan Yun-Feng Liu Ti-Hui Zhang Shi-Jun Weng Xiong-Li Yang Yong-Mei Zhong 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期800-810,共11页
Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission ... Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission are associated with pathophysiological and neurodegenerative disorders,whereas glucagon-like peptide-1 has demonstrated neuroprotective effects.However,it is not yet clear whether diabetes causes alterations in inhibitory input to retinal ganglion cells and whether and how glucagon-like peptide-1 protects against neurodegeneration in the diabetic retina through regulating inhibitory synaptic transmission to retinal ganglion cells.In the present study,we used the patch-clamp technique to recordγ-aminobutyric acid subtype A receptor-mediated miniature inhibitory postsynaptic currents in retinal ganglion cells from streptozotocin-induced diabetes model rats.We found that early diabetes(4 weeks of hyperglycemia)decreased the frequency of GABAergic miniature inhibitory postsynaptic currents in retinal ganglion cells without altering their amplitude,suggesting a reduction in the spontaneous release ofγ-aminobutyric acid to retinal ganglion cells.Topical administration of glucagon-like peptide-1 eyedrops over a period of 2 weeks effectively countered the hyperglycemia-induced downregulation of GABAergic mIPSC frequency,subsequently enhancing the survival of retinal ganglion cells.Concurrently,the protective effects of glucagon-like peptide-1 on retinal ganglion cells in diabetic rats were eliminated by topical administration of exendin-9-39,a specific glucagon-like peptide-1 receptor antagonist,or SR95531,a specific antagonist of theγ-aminobutyric acid subtype A receptor.Furthermore,extracellular perfusion of glucagon-like peptide-1 was found to elevate the frequencies of GABAergic miniature inhibitory postsynaptic currents in both ON-and OFF-type retinal ganglion cells.This elevation was shown to be mediated by activation of the phosphatidylinositol-phospholipase C/inositol 1,4,5-trisphosphate receptor/Ca2+/protein kinase C signaling pathway downstream of glucagon-like peptide-1 receptor activation.Moreover,multielectrode array recordings revealed that glucagon-like peptide-1 functionally augmented the photoresponses of ON-type retinal ganglion cells.Optomotor response tests demonstrated that diabetic rats exhibited reductions in visual acuity and contrast sensitivity that were significantly ameliorated by topical administration of glucagon-like peptide-1.These results suggest that glucagon-like peptide-1 facilitates the release ofγ-aminobutyric acid onto retinal ganglion cells through the activation of glucagon-like peptide-1 receptor,leading to the de-excitation of retinal ganglion cell circuits and the inhibition of excitotoxic processes associated with diabetic retinopathy.Collectively,our findings indicate that theγ-aminobutyric acid system has potential as a therapeutic target for mitigating early-stage diabetic retinopathy.Furthermore,the topical administration of glucagon-like peptide-1 eyedrops represents a non-invasive and effective treatment approach for managing early-stage diabetic retinopathy. 展开更多
关键词 diabetic retinopathy glucagon-like peptide-1 inhibitory synaptic transmission miniature inhibitory postsynaptic currents neurodegeneration neuroprotection patch-clamp recording protein kinase C signaling pathway visual function
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Comparison of binocular visual function among patients with different types of anisometropia 认领 引用
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作者 Li Tang Lei Li +3 位作者 Chunmei Li Yulin Yu Nan Shu Li Zhang 《Advances in Ophthalmology Practice and Research》 2025年第3期182-188,共7页
Objective To compare the perceived eye position,Titmus and stereopsis function across various types of anisometropia to identify differences in binocular visual function.Methods This study included 204 anisometropic p... Objective To compare the perceived eye position,Titmus and stereopsis function across various types of anisometropia to identify differences in binocular visual function.Methods This study included 204 anisometropic patients(observation group,interocular spherical equivalent difference≥1.5D or cylindrical≥1.0D)and 57 non-anisometropic controls(interocular differences0.05).(3)While Titmus results showed no difference between astigmatic and myopic anisometropia groups(P〓〓=〓〓0.72),significant differences existed among other groups(P<0.05).Notably,the hyperopic anisometropia group exhibited the poorest normal rates for vertical PEP,Titmus,and three-order stereopsis among all groups(P〓〓<0.001).Additionally,the astigmatism group outperformed both myopia and hypermetropia groups in 0-order and 1-order stereopsis(P〓〓<0.05).Conclusions The study revealed no significant difference in visual function between anisometropic amblyopia patients who achieved normal BCVA(≤0.0 LogMAR)and non-amblyopic anisometropic controls.However,all forms of anisometropia demonstrated varying degrees of impairment to binocular fusion and stereopsis,with hypermetropic anisometropia showing the most pronounced deficits,particularly in near stereopsis.Notably,vertical PEP instability may contribute to the progression of hyperopic anisometropia. 展开更多
关键词 Anisometropia Stereopsis Perceptual eye positions Titmus Binocular visual function
An effective pharmacological hydrogel induces optic nerve repair and improves visual function 认领 引用 被引量：8
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作者 Lipeng Wang Shan Zhang +5 位作者 Yawen Han Shuo Tang Jiarui Li Lina Bu Dongyu Zhao Hongkui Deng 《Science China(Life Sciences)》 SCIE CAS CSCD 2024年第3期529-542,共14页
Irreversible eye lesions, such as glaucoma and traumatic optic neuropathy, can cause blindness;however, no effective treatments exist. The optic nerve, in particular, lacks the capacity to spontaneously regenerate, re... Irreversible eye lesions, such as glaucoma and traumatic optic neuropathy, can cause blindness;however, no effective treatments exist. The optic nerve, in particular, lacks the capacity to spontaneously regenerate, requiring the development of an effective approach for optic nerve repair, which has proven challenging. Here, we demonstrate that a combination of the small molecules 3BDO and trichostatin A(TSA)—which regulate mTOR and HDAC, respectively—packaged in thermosensitive hydrogel for 4-week-sustained release after intravitreal injection, effectively induced optic nerve regeneration in a mouse model of optic nerve crush injury. Moreover, this combination of 3BDO and TSA also protected axon projections and improved visual responses in an old mouse model(11 months old) of glaucoma. Taken together, our data provide a new, local small molecule-based treatment for the effective induction of optic nerve repair, which may represent a foundation for the development of pharmacological methods to treat irreversible eye diseases. 展开更多
关键词 retinal ganglion cell axon regeneration old-age glaucoma small molecules pharmacological hydrogel visual function repair
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Evaluation of visual functional and morphology change in young patients with idiopathic choroidal neovascularization 认领 引用 被引量：4
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作者 WANG Wen-qiu LIU Hai-yun +8 位作者 LU Feng-qing HU Wei-ting GONG Yuan-yuan WU Ying XU Shan WANG Wei-jun XU Xun WANG Feng-hua SUN Xiao-dong 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第11期1647-1652,共6页
Background Idiopathic choroidal neovascularization （ICNV） is an uncommon disorder affecting primarily individuals younger than the age of 50 years. In CNV patients, no apparent cause can be determined. This study ai... Background Idiopathic choroidal neovascularization （ICNV） is an uncommon disorder affecting primarily individuals younger than the age of 50 years. In CNV patients, no apparent cause can be determined. This study aimed to evaluate the functional and morphological change of the retina with ICNV in young adults. Methods In this retrospective study, 32 eyes of 32 patients with subfoveal or juxta/extra foveal ICNV had been admitted into the Shanghai First People＇s Hospital from January 2009 to July 2010. The functional changes were evaluated using the best corrected visual acuity （BCVA） and the microperimetry in the macular area. 展开更多
关键词 idiopathic choroidal neovascularization optical coherent tomography microperimetry visual function
Self-powered transparent photodetector for subretinal visual functions of wide-field-of-view and broadband perception 认领 引用 被引量：5
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作者 Priyanka Bhatnagar Malkeshkumar Patel +1 位作者 Kibum Lee Joondong Kim 《InfoMat》 SCIE CSCD 2023年第6期89-101,共13页
Natural photoreceptors enable color vision in humans,wherein the eyes detect colors and their corresponding intensities via cone and rod photoreceptors,respectively.Herein,we developed an artificial broadband photorec... Natural photoreceptors enable color vision in humans,wherein the eyes detect colors and their corresponding intensities via cone and rod photoreceptors,respectively.Herein,we developed an artificial broadband photoreceptor with light-color intensity detection similar to that of natural photoreceptors.The developed photoreceptor operates in the self-powered mode and is capable of broadband perception(365–940 nm).The designed metal-oxide heterojunction(n-ZnO/p-NiO)photoreceptor with a thin tin sulfide layer embedded in between is capable of perceiving various colors.It exhibits good transparency in the visible range and displays excellent integration with flexible substrates,highlighting its potential for use in flexible electronics.The fabricated structure has an exceptional response time(≈1 ms)and a wide-field-of-view(150?)compared to the human eye's sensing range(50–100 ms and 108?).The transparent photorecep-tor mimics cones and rods to detect a various wavelength-dependent signals and explicitly differentiate between the intensities of the detected signals,respectively.This is further illustrated by employing the developed photoreceptor to detect colors in real time by generating unique signals corresponding to each color.The demonstration provides the proof of concept for self-biased flexible bioelectronics emulating high-performing visual functions of artificial eyes. 展开更多
关键词 artificial eye broadband retinal visual function transparent photoreceptor wide-field-of-view
Altered intrinsic functional connectivity of the primary visual cortex in youth patients with comitant exotropia: a resting state fMRI study 认领 引用 被引量：17
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作者 Pei-Wen Zhu Xin Huang +5 位作者 Lei Ye Nan Jiang Yu-Lin Zhong Qing Yuan Fu-Qing Zhou Yi Shao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第4期668-673,共6页
AIM： To evaluate the differences in the functional connectivity（FC） of the primary visual cortex（V1） between the youth comitant exotropia（CE） patients and health subjects using resting functional magnetic reson... AIM： To evaluate the differences in the functional connectivity（FC） of the primary visual cortex（V1） between the youth comitant exotropia（CE） patients and health subjects using resting functional magnetic resonance imaging（f MRI） data.METHODS： Totally, 32 CEs（25 males and 7 females） and 32 healthy control subjects（HCs）（25 males and 7 females） were enrolled in the study and underwent the MRI scanning. Two-sample t-test was used to examine differences in FC maps between the CE patients and HCs. RESULTS： The CE patients showed significantly less FC between the left brodmann area（BA17） and left lingual gyrus/cerebellum posterior lobe, right middle occipital gyrus, left precentral gyrus/postcentral gyrus and right inferior parietal lobule/postcentral gyrus. Meanwhile, CE patients showed significantly less FC between right BA17 and right middle occipital gyrus（BA19, 37）.CONCLUSION： Our findings show that CE involves abnormal FC in primary visual cortex in many regions, which may underlie the pathologic mechanism of impaired fusion and stereoscopic vision in CEs. 展开更多
关键词 comitant exotropia functional connectivity primary visual cortex spontaneous activity
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WocEA:The visualization of functional enrichment results in word clouds 认领 引用 被引量：2
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作者 Wanshan Ning Shaofeng Lin +5 位作者 Jiaqi Zhou Yaping Guo Ying Zhang Di Peng Wankun Deng Yu Xue 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2018年第7期415-417,共3页
The integration, analysis and visualization of the big omics data are critical for addressing a broad spectrum of biological questions. One of the most frequently conducted procedures is enrichment analysis, which sta... The integration, analysis and visualization of the big omics data are critical for addressing a broad spectrum of biological questions. One of the most frequently conducted procedures is enrichment analysis, which statistically tests whether individual functional an- notations of Gent Ontology （GO） or Kyoto Encyclopedia of Genes and Genomes （KEGG） are significantly over-or under-represented in an ＂interesting＂ gene or protein list against the reference set （Tavazoie et al., 1999）. 展开更多
关键词 WocEA he visualization of functional enrichment results word clouds
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L-茶氨酸研究的可视化分析及其功能活性和食品应用研究进展 认领 引用 被引量：4
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作者 付佳音 王龙华 +4 位作者 闫瑞瑞 杨涵越 李永焜 燕飞 曲东 《食品工业科技》 EI CAS 北大核心 2026年第1期477-487,共11页
L-茶氨酸(L-Theanine,LTA)是茶叶中独特的游离氨基酸,是茶汤鲜爽味的主要来源,具有多种生物活性,属于新食品原料。本文基于Citespace和VOSviewer对Web of Science核心数据库和中国知网数据库,对2014~2024年LTA相关文献进行可视化分析,... L-茶氨酸(L-Theanine,LTA)是茶叶中独特的游离氨基酸,是茶汤鲜爽味的主要来源,具有多种生物活性,属于新食品原料。本文基于Citespace和VOSviewer对Web of Science核心数据库和中国知网数据库,对2014~2024年LTA相关文献进行可视化分析,其中关键词密度和贡献图谱结果显示LTA相关研究集中在茶叶类型、胁迫反应、LTA的生物活性等方面。因此,本文综述了茶叶LTA含量的影响因素,并重点阐述LTA生物活性作用机制,包括抗氧化、抗热应激、抗抑郁、调节代谢、抗癌、调节免疫、调节肠道菌群、保护神经系统、保护肝脏和保护肠道的作用机制,发现LTA主要通过调控核因子κB(Nuclear factor kappa B,NF-κB)、c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)、信号传导及转录激活因子(Signal transducer and activator of transcription,STAT)和丝裂原活化蛋白激酶(Mitogen-activated protein kinase,MAPK)等信号通路发挥生物活性功能,并总结了当前LTA在食品产业中的实际应用。本文可为LTA的研究和发展提供方向,并为开发LTA功能性食品提供一定的参考。 展开更多
关键词 L-茶氨酸 可视化分析 功能活性 作用机制 食品应用
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