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Genetic susceptibility,environmental risk factors,and incident gastric cancer risk among individuals with different Helicobacter pylori infection status:a population-based study 认领 引用
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作者 Hengmin Xu Hui Ma +9 位作者 Yuxin Wang Xinling Wang Xuan Han Wenjing Zhao Yang Zhang Tong Zhou Jingying Zhang Weicheng You Wenqing Li Kaifeng Pan 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第7期1038-1043,共6页
Gastric cancer(GC)remains a leading cause of cancer mortality worldwide1.Helicobacter pylori(H.pylori)infection is the dominant etiologic factor2,yet GC also arises in individuals without infection or after eradicatio... Gastric cancer(GC)remains a leading cause of cancer mortality worldwide1.Helicobacter pylori(H.pylori)infection is the dominant etiologic factor2,yet GC also arises in individuals without infection or after eradication,suggesting alternative carcinogenic pathways3.Accordingly,increasing attention has been paid to potential differences between H.pylori-negative and-positive GC.Clinicopathologic differences by H.pylori infection status have been reported but most evidence derives from case-control studies in which infection status assessed at diagnosis is prone to misclassification due to prior eradication,spontaneous clearance,or tumor-related changes.As a result,prospective data defining the long-term clinical and biological imprint of baseline H.pylori status are limited. 展开更多
关键词 carcinogenic pathways accordinglyincreasing prospective data clinicopathologic differences gastric cancer gc remains Helicobacter pylori infection population based study environmental risk factors genetic susceptibility
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