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Acquired hemophilia A mimicking trauma-induced coagulopathy in a young polytrauma patient 认领 引用
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作者 Andrea Capponi Carlo Rostagno 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2026年第3期282-283,共2页
Traum a-induced coagulopathy(TIC)occurs in approximately 25%of severely injured patients and is characterized by tissue injury,shock,and endothelial dysfunction.Laboratory diagnosis typically shows abnormalities in th... Traum a-induced coagulopathy(TIC)occurs in approximately 25%of severely injured patients and is characterized by tissue injury,shock,and endothelial dysfunction.Laboratory diagnosis typically shows abnormalities in the prothrombin time(PT),activated partial thromboplastin time(aPTT),fibrinogen level,and platelets(PLTs). 展开更多
关键词 partial thromboplastin platelets acquired hemophilia activated partial thromboplastin time trauma induced coagulopathy polytrauma fibrinogen prothrombin time
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Acquired hemophilia associated with Bullous Pemphigoid:a case report 认领 引用
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作者 Yao-song Gui 《镜湖医学》 2026年第1期61-62,共2页
Introduction Acquired hemophilia A(AHA),also known as acquired factor VIII inhibitor,is a severe bleeding disorder caused by factor VIII autoantibodies and associated with bleeding complications that can be life-threa... Introduction Acquired hemophilia A(AHA),also known as acquired factor VIII inhibitor,is a severe bleeding disorder caused by factor VIII autoantibodies and associated with bleeding complications that can be life-threatening.It has a calculated incidence of 1.3 to 1.5 cases per million population per year in South and West Wales and the United Kingdom[1,2]. 展开更多
关键词 factor VIII inhibitor bleeding disorder acquired hemophilia factor viii autoantibodies severe bleeding disorder acquired factor viii inhibitoris bullous pemphigoid
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Preoperative probing and dilation in nasolacrimal silicone intubation for incomplete primary acquired nasolacrimal duct obstruction 认领 引用
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作者 Hu Cheng Liu Yin +4 位作者 Chen Jing Fang Jinran Xiang Nian Du Fan Zeng Bo 《国际眼科杂志》 CAS 2026年第8期1316-1322,共7页
AIM:To assess the influence of preoperative lacrimal passage probing and dilation on the therapeutic effectiveness of nasolacrimal silicone intubation in cases of incomplete primary acquired nasolacrimal duct obstruct... AIM:To assess the influence of preoperative lacrimal passage probing and dilation on the therapeutic effectiveness of nasolacrimal silicone intubation in cases of incomplete primary acquired nasolacrimal duct obstruction(PANDO).METHODS:A retrospective case-control clinical study was conducted.The study included patients with incomplete PANDO who underwent nasolacrimal silicone intubation at the hospital between October 2022 and October 2024.Participants were categorized into two groups based on their receipt of nasolacrimal duct probing and dilation prior to intubation.Group A consisted of patients who had undergone one or more sessions of nasolacrimal duct probing and dilation before nasolacrimal silicone intubation,while Group B included patients who did not receive nasolacrimal duct probing and dilation before intubation.All patients had their nasolacrimal silicone tubes removed 3 mo postoperatively and were monitored for 6 mo following tube removal to evaluate surgical success rates.RESULTS:A total of 136 patients(152 eyes)completed the six-month follow-up period.The overall surgical success rate for both groups was 72.4%(110/152 eyes).Group A included 22 males and 36 females,mean age 58.09±11.07 y,and achieved a success rate of 82.8%(53/64 eyes),while Group B included 27 males and 51 females,mean age 59.35±8.84 y and attained a success rate of 64.8%(57/88 eyes).The difference in surgical success rates between the two groups was statistically significant(P=0.014).Furthermore,Group A achieved a complete success rate of 67.2%(43/64 eyes),compared to 47.7%(42/88 eyes)in Group B,with this difference also reaching statistical significance(P=0.017).No serious postoperative complications were observed in either group.CONCLUSION:Nasolacrimal silicone intubation is a safe and effective intervention for incomplete PANDO,with preoperative nasolacrimal duct probing and dilation potentially enhancing therapeutic outcomes. 展开更多
关键词 incomplete primary acquired nasolacrimal duct obstruction nasolacrimal silicone intubation nasolacrimal duct probing and dilation success rate
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Long-term survival after pancreaticoduodenectomy for duodenal papillary adenocarcinoma in a patient with acquired immunodeficiency syndrome:A case report and review of literature 认领 引用
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作者 Kang-Ning Li Qing Chen +2 位作者 Chun-Tao Huang Tian-Qi Liu Hong-Fei Li 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第7期335-347,共13页
BACKGROUND Duodenal papillary adenocarcinoma is exceptionally rare in patients with acquired immunodeficiency syndrome(AIDS),and while this would normally be treated by radical resection,such treatment has historicall... BACKGROUND Duodenal papillary adenocarcinoma is exceptionally rare in patients with acquired immunodeficiency syndrome(AIDS),and while this would normally be treated by radical resection,such treatment has historically been considered highrisk in AIDS patients due to their immune deficiencies.CASE SUMMARY This report presents the case of a 63-year-old female with AIDS who underwent pancreaticoduodenectomy for duodenal papillary adenocarcinoma(pT2N1M0,stage IIIA)and achieved 5-year survival.Through standardized antiretroviral therapy,her CD4+levels were maintained above 200 cells/μL.Perioperative infection prophylaxis included piperacillin-tazobactam and ornidazole.Postoperative adjuvant chemotherapy was initiated based on her absolute neutrophil count being≥1.50×109/L but was reduced due to the occurrence of recurrent grade 3 diarrhea;ultimately,the patient could tolerate only 70%of the standard XELOX regimen over four cycles.The surgery was completed without complications.During over 5 years of follow-up,surveillance imaging showed no recurrence or metastasis,the tumor markers remained normal,and her performance status was fully recovered.CONCLUSION This case demonstrates that with immune optimization(CD4+>200 cells/μL),tailored infection prophylaxis,and neutrophil-guided chemotherapy,radical surgery can be feasible and can enable long-term survival in AIDS patients with duodenal papillary adenocarcinoma,suggesting that the CD4+level is a potential threshold for assessing patient eligibility for surgery in comparable cases. 展开更多
关键词 Acquired immunodeficiency syndrome Human immunodeficiency virus Duodenal papillary adenocarcinoma Pancreaticoduodenectomy Case report
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Construction and Use of a Predictive Model for the Risk of ICU-acquired Weakness 认领 引用
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作者 Yaling Li Baoyi Yang Zhenzhen Rao 《Journal of Clinical and Nursing Research》 2026年第4期198-212,共15页
Objective:To explore the risk factors of acquired weakness in ICU patients and construct a prediction model.Methods:Using convenience sampling method,245 intensive care patients admitted to ICUs of three tertiary hosp... Objective:To explore the risk factors of acquired weakness in ICU patients and construct a prediction model.Methods:Using convenience sampling method,245 intensive care patients admitted to ICUs of three tertiary hospitals in Shiyan City from March 2022 to April 2023 were selected,of which 172 cases from March to December 2022 were used as the modeling group and 73 cases from January to April 2023 were used as the validation group.The predictive effect of the model was examined using the area under the curve(AUC)of the receiver operating characteristic curve(ROC)and Hosmer-Lemeshow goodness-of-fit,and the model column line graph was plotted.Results:The incidence of ICU-acquired weakness was 36.63%(63/172)and 38.37%(28/73)in the modeling and validation groups,respectively.Patient’s history of alcohol consumption,mode of admission to the ICU,treatment with CRRT,mechanical ventilation,restraint braking,use of analgesics,use of norepinephrine,use of glucocorticoids,and length of stay in the ICU were the independent influencing factors of acquired weakness in ICU patients(p<0.05).The AUCs of the modeling and validation groups were 0.979 and 0.887,respectively.Conclusion:The risk prediction model constructed in this study can predict the risk of acquired weakness in ICU,which can provide a reference for healthcare professionals to formulate interventions at an early stage. 展开更多
关键词 Intensive care unit Acquired weakness Influence factor analysis Predictive modeling Columnar plots
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Muscle matters:Transforming the care of intensive care unit acquired sarcopenia and myosteatosis 认领 引用 被引量：1
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作者 Sahil Kataria Saketh Vinjamuri Deven Juneja 《World Journal of Clinical Cases》 2025年第33期20-32,共13页
Intensive care unit(ICU)acquired sarcopenia and myosteatosis are increasingly recognized complications of critical illness,characterized by a rapid loss of ske-letal muscle mass,quality,and function.These conditions r... Intensive care unit(ICU)acquired sarcopenia and myosteatosis are increasingly recognized complications of critical illness,characterized by a rapid loss of ske-letal muscle mass,quality,and function.These conditions result from a complex interplay of systemic inflammation,immobilization,catabolic stress,mitochon-drial dysfunction,and immune dysregulation,often culminating in impaired recovery,prolonged hospitalization,and increased long-term mortality.First identified in survivors of sepsis and prolonged mechanical ventilation,these muscle abnormalities were initially described using computed tomography-based assessments of muscle area and density.Subsequent advances in imaging,biomarker discovery,and functional testing have enabled earlier detection and risk stratification across diverse ICU populations.While nutritional optimization and early mobilization form the cornerstone of current prevention and treatment strategies,the emergence of novel approaches,including automated artificial intelligence-based screening,neuromuscular electrical stimulation,and targeted pharmacologic therapies,has broadened the clinical scope of interventions.Despite their significant prognostic implications,ICU-acquired sarcopenia and myosteatosis remain under-recognized in routine critical care practice.This mini-review aims to synthesize current knowledge regarding their pathophysiology,available diagnostic modalities,prognostic relevance,and the evolving landscape of therapeutic strategies for long-term functional recovery in critically ill patients. 展开更多
关键词 Intensive care unit acquired sarcopenia Intensive care unit acquired weakness Myosteatosis Muscle atrophy Muscle weakness
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Recent advances in near-infrared photobiomodulation for the intervention of acquired brain injury 认领 引用 被引量：2
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作者 Yujing Huang Yujing Zhang +2 位作者 Chen Yang Mengze Xu Zhen Yuan 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2025年第1期1-27,共27页
Acquired brain injury(ABI)is an injury that affects the brain structure and function.Traditional ABI treatment strategies,including medications and rehabilitation therapy,exhibit their ability to improve its impairmen... Acquired brain injury(ABI)is an injury that affects the brain structure and function.Traditional ABI treatment strategies,including medications and rehabilitation therapy,exhibit their ability to improve its impairments in cognition,emotion,and physical activity.Recently,near-infrared(NIR)photobiomodulation(PBM)has emerged as a promising physical intervention method for ABI,demonstrating that low-level light therapy can modulate cellular metabolic processes,reduce the in flammation and reactive oxygen species of ABI microenvironments,and promote neural repair and regeneration.Preclinical studies using ABI models have been carried out,revealing the potential of PBM in promoting brain injury recovery although its clinical application is still in its early stages.In this review,we first inspected the possible physical and biological mechanisms of NIR-PBM,and then reported the pathophysiology and physiology of ABI underlying NIR-PBM intervention.Therefore,the potential of NIR-PBM as a therapeutic intervention in ABI was demonstrated and it is also expected that further work can facilitate its clinical applications. 展开更多
关键词 Near-infrared photobiomodulation acquired brain injury traumatic brain injury ischemic stroke
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Moxibustion for human immunodeficiency virus and acquired immunodeficiency syndrome and its complications:a systematic review of randomized controlled trials 认领 引用
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作者 KONG Lingyao ZHANG Xiaowen +3 位作者 WANG Xuehui WANG Zhijie Robinson Nicola LIU Jianping 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2025年第6期1201-1214,共14页
OBJECTIVE:To comprehensively evaluate randomized controlled trials(RCTs)investigating the effects of moxibustion on people with human immunodeficiency virus(HIV)disease.METHODS:A systematic search was conducted across... OBJECTIVE:To comprehensively evaluate randomized controlled trials(RCTs)investigating the effects of moxibustion on people with human immunodeficiency virus(HIV)disease.METHODS:A systematic search was conducted across eight electronic databases up to August 20,2024.The primary outcome were all-cause mortality and acquired immunodeficiency syndrome(AIDS)-related mortality.Two authors independently screened titles and abstracts,and extracted data onto a pre-designed datasheet.Discrepancies were resolved through consensus.The Cochrane risk-of-bias tool 2.0 was used to assess methodological quality,Meta-analysis was performed when appropriate,and the quality of evidence was assessed through Grading of Recommendations,Assessment,Development and Evaluations approach.RESULTS:Eleven RCTs(n=834)on moxibustion for HIV/AIDS were included,focusing on individuals with HIV infection(5 RCTs,n=426),AIDS patients(3 RCTs,n=223),or both(3 RCTs,n=185).Complications identified included diarrhea(5 RCTs),pulmonary infection(1 RCT),anxiety and depression(1 RCT)and peripheral neuropathy(1 RCT).The risk of bias in the included RCTs was assessed as either high or uncertain.No trial reported mortality or the incidence of AIDS-related complications following treatment.Wheat-grain sized cone moxibustion was associated with increased CD4+counts in patients with lung infections[1 RCT,n=36,mean difference(MD)=78.83 cells/μL].Individual studies reported improvements of quality of life,as measured by the World Health Organization Quality of Life-Brief Version(WHOQOL-BREF)and WHOQOL HIV instrument,with various moxibustion types,but clinical heterogeneity prevented data pooling.Additionally,some studies reported symptom improvement,each using different criteria for symptom improvement.Moxa stick moxibustion plus Western Medicine compared with Western Medicine alone showed a non-significant trend towards improved symptom resolution[2 RCTs,n=125,risk ratio=1.19,95%confidence interval(0.99,1.43)].Moxibustion plus antiretroviral therapy(ART)may reduce gastrointestinal adverse events compared to ART alone[1 RCT,n=10014%vs 32%,P<0.05].The quality of evidence was low to very low.CONCLUSION:This systematic review suggests that moxibustion as an adjunct therapy may have potential benefits in improving immune function and quality of life for HIV/AIDS patients.Limited quality of evidence precludes definitive conclusions,and further high-quality research is needed. 展开更多
关键词 moxibustion HIV acquired immunodeficiency syndrome complications systematic review
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Behavior and outcomes of 141 acquired lacrimal sac mucoceles treated via endoscopic dacryocystorhinostomy 认领 引用
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作者 Ying-Jie Ma Guang-Ming Zhou +6 位作者 Zhi-Rong Liu Jin-Fei Wei Xin-Yu Li Bin Dong Lin-Juan Wu Wen-Can Wu Bo Yu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2025年第2期244-250,共7页
AIM:To investigate the clinical profile of patients with acquired lacrimal sac mucocele(ALSM)and evaluate the efficacy of endoscopic dacryocystorhinostomy(En-DCR)for this condition.METHODS:En-DCRs were performed on 14... AIM:To investigate the clinical profile of patients with acquired lacrimal sac mucocele(ALSM)and evaluate the efficacy of endoscopic dacryocystorhinostomy(En-DCR)for this condition.METHODS:En-DCRs were performed on 141 patients with ALSM patients from January 2016 to March 2022.The clinical baseline information and magnetic resonance imaging(MRI)images were recorded and summarized.To assess the effectiveness of En-DCR therapy,both anatomical and functional success rate was assessed during a 12mo follow-up.RESULTS:A total of 141 patients,with a mean age of 57.70±14.11y,were enrolled in this study.Majority of the patients were female(n=91;64.54%)and all had unilateral disease.All patients had a previous history of epiphora and purulent secretion,and the duration from lacrimal duct obstruction to mucocele formation ranged from 6 to 120mo.MRI findings consistently revealed an enlarged sac diameter,fluid accumulation separated by a thin rim from adjacent tissues,which is indicative of lacrimal sac mucocele.En-DCR was performed with an anatomical success rate of 93.62%and a functional success rate of 81.56%.CONCLUSION:ALSM is more commonly seen in females and unilaterally.It is essentially a complication of lacrimal duct obstruction.MRI characteristics can be used for precise clinical diagnosis,while En-DCR emerges as an optimal therapy for this condition.Our results provide a comprehensive reference for the diagnosis and treatment of ALSM. 展开更多
关键词 acquired lacrimal sac mucocele clinical profile magnetic resonance imaging endoscopic dacryocystorhinostomy
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Comprehensive study of community acquired Mycoplasma pneumoniae pneumonia in children in Baoding,China,2023 认领 引用
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作者 Jing Bi Xu Li +6 位作者 He Tang Olga Kalinina Ting-Ting Jiang Wei-Wei Jiao Xi Zeng Alexander Dmitriev Adong Shen 《World Journal of Clinical Pediatrics》 2025年第4期361-375,共15页
BACKGROUND Mycoplasma pneumoniae(M.pneumoniae)is considered to be one of the causative agents of community acquired pneumonia in children with general or severe course of disease.Severe M.pneumoniae pneumonia(SMPP)has... BACKGROUND Mycoplasma pneumoniae(M.pneumoniae)is considered to be one of the causative agents of community acquired pneumonia in children with general or severe course of disease.Severe M.pneumoniae pneumonia(SMPP)has emerged as a crucial global health concern due to high mortality rate in children under 5 years,potentially life-threatening complications,and growing challenges in pediatric treatment associated with rising macrolide resistance.Additionally,MPP can be complicated by other bacterial and/or viral pathogens,which may exacerbate disease severity.After the lifting of strict non-pharmaceutical interventions(NPIs)worldwide,the dramatic rise of incidence of MPP in Asia and Europe was observed.AIM To perform the comprehensive study of community acquired MPP cases registered in 2023 in Baoding Hospital,China.METHODS A total of 1160 children from 1 month to 15 years old with confirmed MPP diagnosis were enrolled in the study.The blood and respiratory samples were collected within the 24 hours after admission.The hematological parameters,biochemical markers,cytokine profiles were assessed.The respiratory samples were tested for the presence of M.pneumoniae and other 23 bacterial/viral pathogens by multiplex polymerase chain reaction(PCR).The macrolide resistance mutations(A2063G,A2064G in the 23S rRNA gene of M.pneumoniae)were determined by PCR.RESULTS Number of MPP cases has dramatically increased starting August with peak in November.SMPP and general MPP(GMPP)were identified in 264 and 896 of 1160 hospitalized children.The binary logistic regression analysis identified six[C-reactive protein(CRP),lactate dehydrogenase,procalcitonin,erythrocyte sedimentation rate,fibrin and fibrinogen degradation products(FDPs),D-dimer]and four(neutrophils,CRP,FDPs,prothrombin time)predictors of SMPP in age groups 2-5 years and 6-15 years,respectively.Children with SMPP showed significantly higher levels of cytokine interleukin(IL)-17F(2-5 years),and cytokines interferon-gamma,tumor necrosis factoralpha,IL-10(6-13 years).Concomitant viral/bacterial pathogens were determined in 24.3%and 28.0%cases of SMPP and GMPP.Among them,Streptococcus pneumoniae(S.pneumoniae)and Haemophilus influenzae(H.influenzae)were predominant.93.2%cases of MPP were associated with macrolide resistant M.pneumoniae.CONCLUSION Specific MPP epidemiological pattern associated with lifting NPIs was revealed:Increase of hospitalized cases,prevalence of S.pneumoniae and H.influenzae among concomitant pathogens,93.2%of macrolide resistant M.pneumonia. 展开更多
关键词 Community acquired Mycoplasma pneumoniae pneumonia Children Macrolide resistance A2063G or A2064G mutations
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Circulating T Regulatory Cells Are Persistently Reduced in Non-Severe Acquired Aplastic Anemia 认领 引用 被引量：1
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作者 Pasqualina Scala Valentina Giudice +3 位作者 Denise Morini Anna Maria Della Corte Carmine Selleri Bianca Serio 《Current Medical Science》 SCIE CAS CSCD 2025年第4期977-984,共8页
Objective Acquired aplastic anemia(aAA)is characterized by an autologous immunological attack against hematopoietic stem and progenitor cells,and immunotolerance disruption is frequent,with reduced T regulatory cells(... Objective Acquired aplastic anemia(aAA)is characterized by an autologous immunological attack against hematopoietic stem and progenitor cells,and immunotolerance disruption is frequent,with reduced T regulatory cells(Tregs)frequencies and increased effector cytotoxic cells.Tregs are reduced in aAA and increase in number after successful immunosuppressive therapies.Methods In this retrospective study,we investigated the frequency of circulating Tregs by multiparametric flow cytometry immunophenotyping in non-severe aAA patients before and after immunosuppressive therapy.The samples were stained with the following antibodies:ECD anti-CD3,PE or PC5 anti-CD4,FITC anti-CD8,and PE anti-CD25,and Tregs were identified by first gating on linear parameters for lymphocyte identification and then for CD3 expression.In CD3+CD4+cells,Tregs were further identified on the basis of CD25 and FOXP3 expression.Results Although the number of Tregs tended to increase after immunosuppressive treatments,their circulating frequency remained lower than that of healthy subjects,regardless of their responsiveness to therapies.Moreover,the relative frequency combined with absolute Treg counts might be more informative in the differential diagnosis of bone marrow failure syndromes.Conclusions The persistent decrease in circulating Tregs could be the result of immunosuppressive agents that could preferentially expand other T-cell subsets.At the same time,an imbalance in immunotolerance might persist,which is also favored by chronic antigen stimulation. 展开更多
关键词 Regulatory T cells(Tregs) Acquired aplastic anemia(aAA) Immnosuppressive therapy(IST) Persistent reduction Nonsevere aplastic anemia FOXP3
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Repeated hemorrhagic ulcers of the esophagus associated with acquired hemophilia A:A case report 认领 引用
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作者 Makoto Saito Kencho Miyashita +6 位作者 Masahiro Ieko Emi Yokoyama Minoru Kanaya Koh Izumiyama Akio Mori Masanobu Morioka Takeshi Kondo 《World Journal of Gastrointestinal Endoscopy》 2025年第12期186-192,共7页
Acquired hemophilia A(AHA)is a rare blood disorder that can cause life-threatening severe bleeding because of the development of autoantibodies(inhibitors)against factor VIII.AHA is common in elderly patients,and alth... Acquired hemophilia A(AHA)is a rare blood disorder that can cause life-threatening severe bleeding because of the development of autoantibodies(inhibitors)against factor VIII.AHA is common in elderly patients,and although most cases are characterized by subcutaneous or intramuscular bleeding,rare cases of gastrointestinal bleeding have been reported.Controlling gastrointestinal bleeding in patients with AHA is difficult even after multiple endoscopic hemostasis or transcatheter arterial embolization procedures,and these patients are prone to rebleeding.CASE SUMMARY We report the case of a 76-year-old Japanese woman with AHA who presented with repeated bleeding from an esophageal ulcer as the initial symptom.A hemorrhagic ulcer was detected in the lower esophagus,and endoscopic hemostasis using radiofrequency ablation was performed seven times over a month.However,this procedure was unsuccessful,and the patient was transferred to our department.Hypertonic saline-epinephrine injection plus clipping was administered for endoscopic hemostasis,but the treatment response of the patient was poor.After the AHA diagnosis was confirmed,a single dose of a mixture of factors VIIa and X was administered as a bypass hemostatic agent,and the bleeding was successfully controlled.In addition,emicizumab,a bispecific monoclonal antibody that is a substitute for activated factor VIII,was administered,and no further rebleeding was observed.CONCLUSION Multidisciplinary interventions between endoscopists and hematologists are essential to manage rare gastrointestinal bleeding caused by coagulation disorders,such as AHA. 展开更多
关键词 Acquired hemophilia A Gastrointestinal bleeding Esophageal ulcer Endoscopic hemostasis Bypass hemostatic agent Emicizumab Case report
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Recurrent hemoptysis after laryngectomy-acquired hemophilia induced by laryngeal cancer surgery and chemoradiotherapy:A case report 认领 引用
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作者 Peng-Wei Zhao Yan-Sheng Hu +3 位作者 Zheng Jiang Mailudan Ainiwaer Jun Liu Fei Chen 《World Journal of Clinical Cases》 2025年第33期76-81,共6页
BACKGROUND Acquired hemophilia A(AHA)is a rare autoimmune bleeding disorder charac-terized by autoantibodies against coagulation factor VIII(FVIII),leading to spon-taneous bleeding in patients without a personal or fa... BACKGROUND Acquired hemophilia A(AHA)is a rare autoimmune bleeding disorder charac-terized by autoantibodies against coagulation factor VIII(FVIII),leading to spon-taneous bleeding in patients without a personal or family history of bleeding disorders.While AHA has been reported in association with various cancers,this case represents,to our knowledge,the first reported instance of AHA following head and neck cancer surgery and subsequent chemoradiotherapy.CASE SUMMARY We present the case of a 65-year-old male with a history of hypopharyngeal squa-mous cell carcinoma(T4bN2cM0,AJCC 8th edition)who developed AHA after extensive surgical resection and chemoradiotherapy.He presented with recurrent hemoptysis and ecchymosis.Coagulation studies showed isolated prolonged activated partial thromboplastin time of 83.8 seconds that did not correct with mixing studies.FVIII activity was<1%,and a Bethesda assay confirmed FVIII inhibitors with a titer of 18.4 Bethesda units.Hemostasis was initially achieved with tranexamic acid and batroxobin.Immunosuppression with prednisone and cyclophosphamide was started;due to gastrointestinal bleeding,rituximab was added.Treatment was later transitioned to azathioprine with prednisone,fol-lowed by tapering.FVIII activity recovered to 188.2%,and the patient remained in remission over six years without AHA or malignancy recurrence.CONCLUSION This case underscores vigilance for AHA after head and neck cancer therapy to enable prompt treatment. 展开更多
关键词 Acquired hemophilia A Hypopharyngeal squamous cell carcinoma Surgery Chemoradiotherapy Paraneoplastic syndrome Immunosuppressive therapy Case report
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Comparative efficacy of botulinum toxin injection versus extraocular muscle surgery in acute acquired comitant esotropia 认领 引用
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作者 Liu Tianyi Zhou Yue +4 位作者 Kuai Pengzhou Guo Yangchen Huang Xiaobo Wang Yong Cao Xin 《国际眼科杂志》 CAS 2025年第11期1721-1727,共7页
AIM:To investigate the therapeutic effects of botulinum toxin A(BTXA)injection versus strabismus surgery in the treatment of acute acquired comitant esotropia(AACE).METHODS:Patient records of AACE cases treated at Fir... AIM:To investigate the therapeutic effects of botulinum toxin A(BTXA)injection versus strabismus surgery in the treatment of acute acquired comitant esotropia(AACE).METHODS:Patient records of AACE cases treated at First People’s Hospital of Nantong from January 2019 to September 2023 were retrospectively analyzed in this study.Patients were categorized into either strabismus surgery or BTXA injection groups based on treatment modality.Further stratification was performed according to preoperative deviation angles[>35 prism diopters(PD)vs≤35 PD]and age(≥18 years adult group vs35 PD,surgery yielded significantly better outcomes than injection therapy in postoperative angle,success rate,and stereopsis recovery(P35 PD and those aged≥18 years.For patients with angles≤35 PD or under 18 years,BTXA injection remains a viable treatment option. 展开更多
关键词 botulinum toxin A acute acquired esotropia extraocular muscle surgery
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Bullous pemphigoid associated with acquired hemophilia A: A case report 认领 引用
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作者 Su-Ye Hu Meng-Can Li +7 位作者 Zi-Jia Hao Xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu Ying Xu Pan-Pan Yang Ling-E Li 《World Journal of Clinical Cases》 2025年第4期28-33,共6页
BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated w... BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must improve.CASE SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 days.CONCLUSION AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary. 展开更多
关键词 Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report
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In-depth Analysis of the Pathogenesis and Research Progress in Cutting-edge Treatment of Type III Acute Acquired Comitant Esotropia 认领 引用
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作者 Ling Jin 《Journal of Clinical and Nursing Research》 2025年第4期37-42,共6页
Type III acute acquired comitant esotropia(AACE)is a special type of binocular coordination disorder with sudden onset characteristics,but its pathogenesis and treatment strategies remain unclear.This article analyzes... Type III acute acquired comitant esotropia(AACE)is a special type of binocular coordination disorder with sudden onset characteristics,but its pathogenesis and treatment strategies remain unclear.This article analyzes the incidence and classification characteristics of Type III AACE,and explores its pathogenesis from multiple perspectives including clinical medicine,neuroscience,and neuro-ophthalmology.It is found that this disease is associated with factors such as decompensation of phoria,dysfunction of the visual center,abnormalities in the physiological and anatomical structure of extraocular muscles,accommodative factors,and disorders of convergence and divergence.The prognosis of Type III AACE is excellent with treatments such as botulinum toxin injection and surgery,and adjunctive therapies like prism adaptation test and visual function training can enhance the management effect.This article provides an in-depth analysis of the pathogenesis and cutting-edge treatment techniques for patients with Type III AACE,which can offer guidance for the subsequent diagnosis and treatment of such patients. 展开更多
关键词 Type III acute acquired comitant esotropia Treatment progress Pathogenesis
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Clinical Decision on Disorders of Consciousness After Acquired Brain Injury:Stepping Forward 认领 引用 被引量：14
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作者 Rui-Zhe Zheng Zeng-Xin Qi +3 位作者 Zhe Wang Ze-Yu Xu Xue-Hai Wu Ying Mao 《Neuroscience Bulletin》 SCIE CAS CSCD 2023年第1期138-162,共25页
Major advances have been made over the past few decades in identifying and managing disorders of consciousness(DOC)in patients with acquired brain injury(ABI),bringing the transformation from a conceptualized definiti... Major advances have been made over the past few decades in identifying and managing disorders of consciousness(DOC)in patients with acquired brain injury(ABI),bringing the transformation from a conceptualized definition to a complex clinical scenario worthy of scientific exploration.Given the continuously-evolving framework of precision medicine that integrates valuable behavioral assessment tools,sophisticated neuroimaging,and electrophysiological techniques,a considerably higher diagnostic accuracy rate of DOC may now be reached.During the treatment of patients with DOC,a variety of intervention methods are available,including amantadine and transcranial direct current stimulation,which have both provided class II evidence,zolpidem,which is also of high quality,and non-invasive stimulation,which appears to be more encouraging than pharmacological therapy.However,heterogeneity is profoundly ingrained in study designs,and only rare schemes have been recommended by authoritative institutions.There is still a lack of an effective clinical protocol for managing patients with DOC following ABI.To advance future clinical studies on DOC,we present a comprehensive review of the progress in clinical identification and management as well as some challenges in the pathophysiology of DOC.We propose a preliminary clinical decision protocol,which could serve as an ideal reference tool for many medical institutions. 展开更多
关键词 Clinical decision Disorders of consciousness Acquired brain injury Identification Management
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Effect of treatment course of comprehensive intervention with Traditional Chinese Medicine on mortality of acquired immunodeficiency syndrome patients treated with combined antiretroviral therapy 认领 引用 被引量：11
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作者 Guo Huijun Wang Jian +3 位作者 Li Zhengwei Jiang Ziqiang Xu Qianlei Xu Liran 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2016年第4期411-417,共7页
OBJECTIVE:To investigate the effect of a treatment course of comprehensive intervention with Traditional Chinese Medicine(TCM) on the mortality of patients with acquired immunodeficiency syndrome(AIDS) treated with co... OBJECTIVE:To investigate the effect of a treatment course of comprehensive intervention with Traditional Chinese Medicine(TCM) on the mortality of patients with acquired immunodeficiency syndrome(AIDS) treated with combined antiretroviral therapy(c ART).METHODS:AIDS patients who had taken c ART in a national TCM human immunodeficiency virus treatment trial program(NTCMTP) before 2009 were enrolled in this study and followed for 36 months from November 2009.Patients enrolled in the NTCMTP in 2004 were taken as the first group,those enrolled in 2006 as the second group,and those enrolled in 2009 as the third group.Cumulative survival rates were calculated by the life table method.Survival curves for subgroups were compared by the log-rank test.Hazard ratios were calculated with a Cox proportional hazards model.RESULTS:A total of 1443 AIDS patients were followed for 3 years(4198 person-years).During this period,91(6.3%) patients died and 13(0.9%) were lost to follow-up.The total mortality rate was 2.17/100 person-years.The mortality rate of patients enrolled in the NTCMTP in 2004 was 1.49/100 person-years,which was lower than that of patients enrolled in 2006(2.23/100 person-years) and 2009(3.48/100 person-years).After adjusting for other factors,a shorter time of treatment with TCM,male sex,older age,lower CD4 + T-cell counts,and long-term treatment with c ART were risk factors of mortality.CONCLUSION:Long-term treatment with TCM decreased the mortality risk of AIDS patients.Factors such as being male,older age,CD4+ T-cell counts,and time of treatment with TCM and c ART were correlated with mortality. 展开更多
关键词 Acquired immunodeficiency syndrome Antiretroviral therapy highly active Mortality Medicine Chinese traditional Retrospective cohort study
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Differences in acquired immune deficiency syndrome treatment and evaluation strategies between Chinese and Western Medicine 认领 引用 被引量：9
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作者 Liu Zhibin Li Xia +2 位作者 Yang Jiping Xu Liran Guo Huijun 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2015年第6期718-722,共5页
Complementary and alternative medicine, including Chinese medicine(CM), has been used to treat acquired immune deficiency syndrome(AIDS) for almost 30 years. We aimed to compare the main differences between AIDS treat... Complementary and alternative medicine, including Chinese medicine(CM), has been used to treat acquired immune deficiency syndrome(AIDS) for almost 30 years. We aimed to compare the main differences between AIDS treatment and evaluation strategies between CM and Western Medicine(WM), and analyze advantages and disadvantages.The characteristics of integrative medicine(IM),based on CM and WM, include a patient-centered mode of medicine based on evidence. IM focuses on complex intervention and management with systemic and individual treatment. The evaluation indexes of IM might consist of objective indicators and subjective indexes. IM might be a more valuable method for treating AIDS in the future instead of WM or CM alone. 展开更多
关键词 Acquired immunodeficiency syn-drome HIV Complementary therapies Medicine,Chinese Traditional Integrative medicine
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Efficacy of integrated Traditional Chinese Medicine and anti-retroviral therapy on immunological nonresponse in patients with human immunodeficiency virus/acquired immunodeficiency syndrome: a Meta-analysis of randomized controlled trials 认领 引用 被引量：8
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作者 TAO Zhuang HUANG Xiaojie +10 位作者 LIU Ying WANG Ru DONG Jipeng LIANG Biyan ZOU Wen GAO Guojian WANG Zhuo ZHANG Ke WU Hao ZHANG Tong WANG Jian 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2021年第5期669-676,共8页
OBJECTIVE:To explore the efficacy of integrating Traditional Chinese Medicine(TCM)and anti-retroviral therapy(ART),a customized combination of different classes of medications which was also called cock-tail treatment... OBJECTIVE:To explore the efficacy of integrating Traditional Chinese Medicine(TCM)and anti-retroviral therapy(ART),a customized combination of different classes of medications which was also called cock-tail treatment,on the immunological nonresponse(INR)in people living with human immunodeficiency virus(HIV)(PLWH).METHODS:Relevant literature in databases such as China National Knowledge Infrastructure Database(CNKI),Wanfang Digital Journal,Chinese Medical Journal Database(CMJD),Chinese Biomedical Literature Database(CBM),Pub Med,Cochrane,and Embase was reviewed by two independent investigators.Data were extracted from the studies according to the eligible criteria and analyzed using Review Manager 5.3.RESULTS:Nine randomized controlled trials(RCTs)with 1078 patients were analyzed.Our analyses showed that CD4 T cell counts in the treatment group improved compared with that in the control group[mean difference(MD)=13.51,95%confidence interval(CI):7.42-19.60,P<0.0001].There was no significant difference between the treated and control groups after 3 months(MD=25.31,95%CI:-2.78 to 53.41,P=0.08).However,after 6 and 12 months,the response of the treatment group was superior to the control group(MD=27.45,95%CI:7.09-47.81,P=0.008 and MD=27.34,95%CI:6.31–48.37,P=0.01,respectively).The clinical efficacy of the treatment group was also higher than that of the control group(RR=1.75,95%CI:1.16-2.65,P=0.007).However,CD45 RO and CD45 RA T cell counts did not differ significantly between the two groups(MD=12.37,95%CI:-6.71 to 31.45,P=0.20 and MD=5.67,95%CI:-3.00 to14.35,P=0.20,respectively).CONCLUSION:The combined treatment strategy of integrated TCM and Western Medicine promotes long-term reconstitution of the immune system and thus,is beneficial and has potential use for improving INR in PLWH.However,large-scale RCTs are required to provide evidence for optimal intervention strategies. 展开更多
关键词 Medicine,Chinese Traditional HIV acquired immunodeficiency syndrome immunological nonresponse anti-retroviral agents Metaanalysis
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