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Computed tomography with carcinoembryonic antigen and carbohydrate antigen 19-9 in diagnosing lymph node metastasis of early gastric cancer 认领 引用
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作者 Hong-Zhi Chen Ping Zhang Jun Ma 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第2期112-121,共10页
BACKGROUND Gastric cancer(GC)is the fifth most prevalent and fourth most lethal malignancy globally.China bears a disproportionately high burden,accounting for 44.0%of new cases and 48.6%of deaths worldwide.In early G... BACKGROUND Gastric cancer(GC)is the fifth most prevalent and fourth most lethal malignancy globally.China bears a disproportionately high burden,accounting for 44.0%of new cases and 48.6%of deaths worldwide.In early GC(EGC),the presence of lymph node metastasis(LNM)is a critical prognostic determinant that directly guides therapeutic strategy.While multi-detector computed tomography(CT)and serum biomarkers carcinoembryonic antigen(CEA)/carbohydrate antigen 19-9(CA19-9)are established diagnostic tools,each demonstrates limited efficacy when used independently.This study therefore aims to verify whether a combined diagnostic approach integrating multi-detector CT(MDCT)with serum CEA/CA19-9 can significantly improve the accuracy of LNM detection in EGC patients.AIM To investigate the diagnostic value of CT combined with CEA or CA19-9 for detecting LNM in EGC.METHODS This retrospective study included 120 patients with EGC confirmed by gastroscopic biopsy at our institution(Huai’an Hospital of Huai’an City)between February 2024 and August 2024.Based on postoperative pathological findings,participants were categorized into a LNM group(n=60)and a non-metastasis group(n=60).All patients underwent MDCT scanning and serum CEA and CA19-9 level measurements.The diagnostic efficacy of CT,CEA,and CA19-9 alone and in combination was evaluated using receiver operating characteristic(ROC)curve and Kappa consistency analysis.RESULTS Serum analysis showed significantly elevated CEA and CA19-9 levels and higher positivity rates in the metastasis group(P<0.0001).ROC analysis yielded area under the curves of 0.9443(CEA)and 0.9292(CA19-9),with Kappa values of 0.683 and 0.650,respectively.CT revealed significantly greater short-axis diameter,CT attenuation,blood volume,and permeability in metastatic nodes(P<0.05),whereas blood flow and mean transit time showed no significant differences.CT alone demonstrated 85.00%sensitivity and 95.00%specificity(Kappa=0.800).Combined diagnosis improved sensitivity to 91.67%(CT+CEA)and 90.00%(CT+CA19-9),with specificities of 90.00%and 88.33%,respectively.CONCLUSION The combination of CT with CEA or CA19-9 improves sensitivity for detecting LNM in EGC,supporting personalized treatment planning and demonstrating clinical value. 展开更多
关键词 Computed tomography Carcinoembryonic antigen Carbohydrate antigen 19-9 Gastric cancer Lymph node metastasis
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Emerging strategies for monkeypox:antigen and antibody applications in diagnostics,vaccines,and treatments 认领 引用 被引量：1
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作者 Wei Wang Jia-Xiu Li +5 位作者 Si-Qi Long Zi-Ning Liu Xi-Peng Li Zhi-Hang Peng Ju-Dun Zheng Yu-Hui Liao 《Military Medical Research》 SCIE CAS CSCD 2026年第3期479-506,共28页
Monkeypox,a zoonotic illness caused by monkeypox virus(MPXV),has been declared a public health emergency of international concern by the World Health Organization(WHO)on two separate occasions.The rapid spread and wid... Monkeypox,a zoonotic illness caused by monkeypox virus(MPXV),has been declared a public health emergency of international concern by the World Health Organization(WHO)on two separate occasions.The rapid spread and widespread transmission are closely associated with various proteins involved in the MPXV lifecycle,particularly surface antigen proteins found in mature virion(MV)and enveloped virion(EV),such as A29L,M1R,B6R,and A35R.These antigens are highly conserved in MPXV and vaccinia virus(VACV),possessing cross-protective capabilities that can trigger broad immune protection against multiple orthopoxviruses,including MPXV.Vaccines based on DNA,mRNA,and recombinant proteins,targeting these antigens effectively address the current lack of specific monkeypox vaccines by triggering strong immune responses and ensuring the prevention of monkeypox.Compared to traditional vaccines,multi-epitope vaccines designed using computational tools such as reverse vaccinology and immunoinformatics offer lower development costs and faster validation processes.These multi-epitope vaccines also provide adaptability to mutations in MPXV strains.Additionally,these antigens and corresponding antibodies are useful for diagnosis and therapeutic monitoring,supporting early detection and offering novel treatments for cases resistant to existing antiviral drugs.This review provides a brief summary of recent progress and emerging trends in monkeypox detection,vaccine development,and antibody-based therapy targeting these antigens,offering new insights for monkeypox prevention and control. 展开更多
关键词 Monkeypox Monkeypox virus(MPXV) Antigens Antibodies Vaccines Detection Therapy Monoclonal antibodies Mature virion(MV) Enveloped virion(EV)
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Diagnostic and prognostic values of pancreatic juice carbohydrate antigen 19-9 and carcinoembryonic antigen levels in patients with pancreatic cancer 认领 引用
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作者 Bojan Trogrlić Borna Kovačić +4 位作者 Dejan Hil IvanŠerić VeronikaŠikić Zrinka Požgain Goran Augustin 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第5期106-116,共11页
BACKGROUND The estimated 5-year survival rate of pancreatic cancer is 13%,with a median survival of 4 months.Therefore,early detection and personalized treatment are essential.Carbohydrate antigen 19-9(CA 19-9)and car... BACKGROUND The estimated 5-year survival rate of pancreatic cancer is 13%,with a median survival of 4 months.Therefore,early detection and personalized treatment are essential.Carbohydrate antigen 19-9(CA 19-9)and carcinoembryonic antigen(CEA)help diagnose the disease and predict metastasis and recurrence.Pancreatic juice(PJ)contains tumor-specific proteins released by pancreatic cancer cells,which can be collected during surgical resection or endoscopic retrograde cholangiopancreatography(ERCP).The prognostic significance of CA 19-9 and CEA levels in PJ remains uncertain.AIM To hypothesize that CA 19-9 and CEA concentrations in PJ are significantly higher in pancreatic cancer patients than in those with benign conditions,even when serum levels are normal,suggesting potential predictive value for 2-year and 5-year survival outcomes.METHODS A prospective cohort study conducted over 10 years involved patients with resectable pancreatic cancer who underwent pancreaticoduodenectomy(Whipple procedure),along with a control group with benign conditions.PJ was collected during the Whipple procedure from the main pancreatic duct after the resection of the pancreatic head and during ERCP in patients with benign hepatobiliary conditions.The samples were analyzed using the“ECLIA”method(Roche Elecsys 1010/2010).Data analysis involved Fisher’s exact test,the Mann-Whitney U test,and the log-rank test.RESULTS The study involved 24 patients,of whom 17(71%)underwent surgery for pancreatic cancer,and 7(29%)had ERCP.Two-year survival was seen in 8(47%)patients,and 5-year survival in 5(29%).Significantly higher levels of PJ CA 19-9 and CEA were found in the operated group.All patients with serum CA 19-9<25 U/mL survived at least 2 years after surgery,which was a statistically significant difference(Fisher’s exact test,P=0.03).Patients with CA 19-9 levels≥25 U/mL had significantly shorter 2-year and 5-year survival than those with CA 19-9<25 U/mL(Log-rank test,P=0.04).There were no significant differences in serum and PJ CEA levels or PJ CA 19-9 concentrations based on 2-year and 5-year survival outcomes.CONCLUSION CA 19-9 is a prognostic biomarker that enables a personalized approach to adjuvant therapy.Furthermore,these findings have significant clinical implications for future research.CA 19-9 levels in PJ may help more accurately distinguish pancreatic adenocarcinoma from pancreatitis.Additionally,levels below 25 mL/U PJ CA19-9 suggest a better prognosis and survival,which could be used to enhance patient monitoring during current procedures.Collecting specimens during ERCP can help distinguish pancreatic cancer from pancreatic inflammation,preventing unnecessary surgeries and guiding appropriate interventions. 展开更多
关键词 Pancreatic cancer Tumor markers Pancreatic juice Survival Carbohydrate-antigen 19-9 Carcinoembryonic antigen
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Advances and challenges of chimeric antigen receptor T cell therapy in digestive system malignancies 认领 引用
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作者 Chen Wang Zi-Ke Chen +2 位作者 Yu-Gang Wang Min Shi Jin Zhang 《World Journal of Clinical Oncology》 2026年第2期53-61,共9页
Chimeric antigen receptor T cell therapy(CAR-T)has revolutionized the treatment of hematologic malignancies,but its success in solid tumors,particularly those of the digestive system,remains limited.Tumors of the gast... Chimeric antigen receptor T cell therapy(CAR-T)has revolutionized the treatment of hematologic malignancies,but its success in solid tumors,particularly those of the digestive system,remains limited.Tumors of the gastrointestinal system,including gastric,colorectal,esophageal,hepatic,and pancreatic malignancies,represent a significant global health burden with high morbidity and mortality.Recent advances in antigen selection,chimeric antigen receptor design,delivery techniques,and combinatorial approaches have sparked renewed interest in CAR-T immunotherapy for these cancers.This article discusses recent progress in CAR-T development across the major digestive system tumors,outlines tumor-specific targets and clinical trials,highlights prevailing challenges and potential solutions,and proposes strategic directions for the next generation of CAR-T therapies in solid tumors. 展开更多
关键词 Chimeric antigen receptor T cell therapy Digestive system tumors Gastrointestinal cancers Chimeric antigen receptor design Immunotherapy
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Association of carcinoembryonic antigen/carbohydrate antigen 19-9 with gastric cancer recurrence and chemotherapy toxicities 认领 引用
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作者 Yue Qi Chen-Xuan Wu 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第4期155-161,共7页
BACKGROUND Gastric cancer is a major global health burden and ranks among the most common and deadly cancers in China and worldwide.Tumor markers,particularly carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9... BACKGROUND Gastric cancer is a major global health burden and ranks among the most common and deadly cancers in China and worldwide.Tumor markers,particularly carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9),are vital for diagnosis,prognosis,and monitoring.Elevated CEA and CA19-9 levels are correlated with advanced disease,high recurrence risk,and poor survival.However,their specific utility in predicting recurrence during adjuvant chemotherapy and association with chemotherapy-induced toxicities require further exploration.This study aimed to analyze the correlation among CEA/CA19-9 levels,postoperative recurrence,and chemotherapy-related toxicities in gastric cancer to develop personalized treatment strategies.AIM To identify the correlation of serum CEA and CA19-9 levels with postoperative recurrence and chemotherapy toxicity in patients with gastric cancer to guide treatment.METHODS We enrolled 74 patients with gastric cancer who underwent radical resection and adjuvant S-1 and oxaliplatin chemotherapy between January 2022 and December 2023.All the patients completed six chemotherapy cycles.They were categorized into the recurrence and non-recurrence groups based on 1-year postoperative follow-up.We compared CEA and CA19-9 levels and adverse gastrointestinal reactions.The patients were also stratified by elevated(>37 U/mL)or normal(≤37 U/mL)CA19-9 levels to compare recurrence rates and recurrence-free survival(RFS).Finally,we analyzed the correlation of CEA and CA19-9 levels with postoperative recurrence,RFS,and gastrointestinal toxicities.RESULTS The mean postoperative serum CEA(59.58±11.95)ng/mL and CA19-9(104.25±28.64)U/mL levels(averaged from three time-point measurements)in the recurrence group were significantly higher than that in the non-recurrence group(44.33±8.39 ng/mL,40.81±12.47 U/mL)(P<0.05).Patients with elevated mean postoperative CA19-9 levels(70.00%,6.25±0.85 months)had a significantly higher recurrence rate and shorter mean RFS than those with normal levels(7.41%,9.83±0.97 months)(P<0.05).The recurrence group experienced significantly more severe gastrointestinal adverse reactions[mild(33.33%),moderate(44.44%),and severe(22.22%)]than the non-recurrence group[mild(58.93%),moderate(37.50%),and severe(3.57%)](P<0.05).CEA and CA19-9 levels increased significantly with the severity of adverse gastrointestinal reactions(P<0.05).CEA and CA19-9 levels correlated positively with the recurrence and severity of adverse gastrointestinal reactions(P<0.05)and negatively with RFS(P<0.05).CONCLUSION Serum CEA and CA19-9 levels could serve as effective prognostic indicators in gastric cancer.Postoperative monitoring of these markers could detect potential recurrence,assess gastrointestinal toxicity,and predict RFS,thereby guiding clinical decision-making. 展开更多
关键词 Gastric cancer Carcinoembryonic antigen Carbohydrate antigen 19-9 Gastrointestinal adverse reactions Recurrence Recurrence-free survival Correlation
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Perioperative serum carcinoembryonic antigen:Powerful marker for prognostic prediction and adjuvant chemotherapy decision-making in patients with stage II and III colorectal cancer 认领 引用
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作者 Fen-Qi Du Wen-Jie Song +7 位作者 Da Yang Yan-Long Liu Jin-Xue Tong Jia-Lu Liu Liu-Dan Mai Xin-Hao Han Qiu-Ju Zhang Rui Zhang 《World Journal of Gastroenterology》 SCIE CAS 2026年第9期62-86,共25页
BACKGROUND Assessment of the prognosis,follow-up monitoring,and adjuvant treatment decision-making for patients with stage II and III colorectal cancer(CRC)are controversial,as CRC harbors tremendous heterogeneity.Car... BACKGROUND Assessment of the prognosis,follow-up monitoring,and adjuvant treatment decision-making for patients with stage II and III colorectal cancer(CRC)are controversial,as CRC harbors tremendous heterogeneity.Carcinoembryonic antigen(CEA)is an important tumor marker;however,the use of this marker in the management of CRC has not garnered adequate attention.AIM To determine the significance of perioperative CEA levels in prognostic stratification and treatment decision making to provide personalized diagnosis and treatment for patients with stage II and III CRC.METHODS Patients in the training and validation cohorts were diagnosed with primary stage II or III CRC.Preoperative CEA(pre-CEA)and postoperative CEA(post-CEA)were collectively defined as perioperative CEA.Kaplan-Meier(K-M)survival analyses were used to describe patient survival.Cox stepwise regression analysis based on Akaike information criterion was used to determine the prognostic value of clinicopathological characteristics.Nomograms were developed to predict the probability of overall survival(OS)and disease-free survival(DFS).Annual hazard curves and pie charts were used to demonstrate the features of recurrence or metastasis.Differences were considered statistically significant at P<0.05.RESULTS A total of 2496 and 1293 patients were included in the training and validation cohorts,respectively.K-M analysis indicated that patients with elevated perioperative CEA had poorer OS and DFS,with post-CEA being an independent prognostic factor for OS and DFS.Nomograms based on factors associated with prognosis were constructed,which showed good predictive ability for 3-,5-,and 7-year OS and DFS.Patients with elevated perioperative CEA were more likely to have recurrence or metastasis,and the period of the second year after surgery was the peak time of recurrence or metastasis.OS and DFS were significantly worse in patients without adjuvant chemotherapy when they had elevated perioperative CEA.Adjuvant chemotherapy could significantly improve the OS of patients with elevated perioperative CEA.Patients with elevated post-CEA who received XELOX could achieve better OS and DFS.CONCLUSION Perioperative CEA demonstrate sufficient sensitivity in the prognosis prediction and follow-up of patients with stage II and III CRC.Furthermore,perioperative CEA,especially post-CEA,show promise in guiding adjuvant chemotherapy,suggesting potential for further study. 展开更多
关键词 Colorectal cancer Perioperative carcinoembryonic antigen Prognostic marker Recurrence Metastasis Adjuvant chemotherapy
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EBV nuclear antigen 1 hijacks DDX5/BZLF1 axis to facilitate viral lytic replication 认领 引用
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作者 Li Yang Shuyu Xin +7 位作者 Shen Li Pengfei Cao Zeyu Sun Mingjuan Jiang Yujie Xin Xiaoling Su Jing Yang Jianhong Lu 《Virologica Sinica》 SCIE CAS CSCD 2026年第2期314-328,共15页
Epstein-Barr virus(EBV)lytic replication is a key driver of viral dissemination and tumorigenicity in epithelial malignancies,such as nasopharyngeal carcinoma(NPC)and gastric cancer(GC).However,the underlying molecula... Epstein-Barr virus(EBV)lytic replication is a key driver of viral dissemination and tumorigenicity in epithelial malignancies,such as nasopharyngeal carcinoma(NPC)and gastric cancer(GC).However,the underlying molecular mechanism and effective therapeutic strategy remain largely unknown.Here,we analyzed the EBV nuclear antigen 1(EBNA1)interactome and identified DEAD-box helicase 5(DDX5)as its novel partner.The N-terminal region(amino acids 1-88)of EBNA1 and the C-terminal domain of DDX5 were crucial for their binding.EBNA1 stabilized the DDX5 protein by impeding its proteasomal degradation via K48-linked polyubiquitin.EBNA1 facilitated EBV lytic replication in a DDX5-dependent manner.Furthermore,DDX5 bound to the promoter of BZLF1,which is the key switch of EBV reactivation,thus transactivating BZLF1 to drive viral lytic replication.Moreover,the small molecule inhibitor FL118 was able to disrupt this process by promoting DDX5 degradation,unveiling FL118 as a new potential antiviral drug.Our findings established a new functional axis of EBNA1/DDX5/BZLF1,adding to the knowledge about the role of EBNA1 in the regulation of EBV life cycle,particularly lytic replication.The study also provided a potential therapeutic strategy for EBV-associated epithelial tumors. 展开更多
关键词 Epstein-Barr virus(EBV) Epstein-Barr virus nuclear antigen 1 (EBNA1) Dead-box helicase 5(DDX5) FL118 Lytic replication
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Breakthroughs of chimeric antigen receptor T-cell therapy in hematological malignancies:From ex vivo to in vivo 认领 引用
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作者 Xuying Pei Yuxuan Du +1 位作者 Meng Lyu Xiaojun Huang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2026年第3期291-294,共4页
Cellular immunotherapy has transformed cancer treatment in recent years,with chimeric antigen receptor(CAR)-T cell therapy emerging as one of the most important breakthroughs.Since the first CAR-T products were approv... Cellular immunotherapy has transformed cancer treatment in recent years,with chimeric antigen receptor(CAR)-T cell therapy emerging as one of the most important breakthroughs.Since the first CAR-T products were approved,this therapy has demonstrated remarkable efficacy in hematological malignancies,particularly in relapsed or refractory B-cell cancers.As reported,antiCD19 CAR-T cell therapy has produced remarkable clinical responses in B-cell acute lymphoblastic leukemia(B-ALL)and B-cell lymphomas,with complete remission rates exceeding 80%in many clinical trials. 展开更多
关键词 Hematological Malignancies Cancer Treatment hematological malignanciesparticularly cellular immunotherapy Ex vivo vivo Chimeric Antigen Receptor T cell Therapy CAR T Cell Therapy
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Human leukocyte antigen variants and clinical features of primary biliary cholangitis:Cumulative contributions 认领 引用
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作者 Abdellatif Bouayad 《World Journal of Clinical Cases》 2026年第5期52-55,共4页
This letter to the editor highlights the importance of considering potential cumulative contributions among human leukocyte antigen(HLA)alleles in shaping the clinical manifestations of primary biliary cholangitis.Com... This letter to the editor highlights the importance of considering potential cumulative contributions among human leukocyte antigen(HLA)alleles in shaping the clinical manifestations of primary biliary cholangitis.Complementing the overview by Curto et al,which focused on non-HLA candidate genes,this paper emphasizes that specific haplotypes of HLA-DRB1,HLA-DQA1,and HLA-DQB1,as well as HLA-G*01:01:01:08/UTR-1,may modulate disease heterogeneity,predisposition to primary biliary cholangitis and autoimmune hepatitis overlap syndrome,disease progression,and poorer therapeutic response.A comprehensive understanding of these HLA polymorphisms and their interactive effects is essential for improving risk stratification and guiding personalized management of this complex autoimmune liver disease. 展开更多
关键词 Human leukocyte antigen class II Human leukocyte antigen-G Primary biliary cholangitis Prognosis Primary biliary cholangitis-autoimmune hepatitis overlap syndrome Therapy response
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Advances in mucosal vaccines:Design strategies for antigens,adjuvants,and delivery systems 认领 引用
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作者 Jiaxin Guo Yongyi Xie +4 位作者 Muhammad Waqqas Hasan Yongcheng Zhu You Zhou Zhengfeng Li Wenjie Chen 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期230-243,共14页
Mucosal vaccines would be game-changing for blocking pathogenic transmission,prompting protection where microorganism first enters that those intramuscular ones could not be able to achieve.The exploration of the vacc... Mucosal vaccines would be game-changing for blocking pathogenic transmission,prompting protection where microorganism first enters that those intramuscular ones could not be able to achieve.The exploration of the vaccines at mucosal surfaces is gaining momentum due to the unique immune reservoir they offer in a minimally invasive manner.Nevertheless,the application of mucosal vaccines faces challenges,including barriers such as degrading enzymes,mucus interference,and clearance mechanisms.The field of mucosal vaccination is still in its early stages,and its advancement will significantly benefit from foundational inquiries into immune activation mechanisms and the innovation of delivery technologies for optimal efficacy.It is highly central to design efficient systems for mucosal vaccine development,herein,this article offers the insights towards the status,bottlenecks and solutions in this field,the intricacies of the immune response,fundamental mechanisms,applications of the delivery strategies for various forms of mucosal vaccines are explored.Collectively,this review conducts systematical analysis on biological and chemical strategies designed to augment vaccine uptake across mucosal tissues,antigen design and delivery methods strengthening vaccination efficacy,with emphasis on the emerging m RNA mucosal vaccines,offering new insights into recent advancements,trends and future scenarios,aiming to harness mucosal immunity(MI)for comprehensive protection against infections and other diseases. 展开更多
关键词 Mucosal vaccine Mucosal immunity Adjuvants Mucosal delivery systems Antigen design
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Immune evasion in classical swine fever:Viral modulation of antigen-presentation pathways 认领 引用
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作者 Nagarajan Siddharthan Muruganantham Vijay +4 位作者 Mahadevaswamy Roopa Kuralayanapalya Puttahonnappa Suresh Jagadish Hiremath Shivasharanappa Nayakvadi Sharanagouda S.Patil 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2026年第8期330-341,共12页
Classical swine fever remains a major threat to global pig production systems,despite decades of sustained control endeavours.Its causative agent classical swine fever virus(CSFV)employs a highly coordinated set of im... Classical swine fever remains a major threat to global pig production systems,despite decades of sustained control endeavours.Its causative agent classical swine fever virus(CSFV)employs a highly coordinated set of immune evasion mechanisms to weaken host antiviral defences and permit extensive viral replication.A central focus of this strategy is the antigen-presentation machinery,where CSFV disrupts both major histocompatibility complex class(MHC)-Ⅰand MHC-Ⅱpathways in macrophages and dendritic cells,which are its primary immune cell reservoirs.By suppressing interferon signaling,dysregulating NF-κB activation,and impairing the maturation of antigen-presenting cells,CSFV compromises peptide processing,co-stimulatory signaling,and T-cell priming.These defects propagate through the adaptive immune system,leading to delayed cytotoxic responses,inadequate CD4+T-cell help,and impaired humoral immunity.CSFV simultaneously reshapes macrophage polarization,drives profound dendritic cell dysfunction,induces lymphoid apoptosis,and modulatesγδT-cell activity in a manner that correlates with viral virulence.In addition,viral remodeling of intracellular organelles further limits antigen presentation and exacerbates immunopathology.Together,these interconnected mechanisms create a permissive cellular environment that facilitates viral persistence and amplifies disease severity.Understanding how CSFV manipulates antigen-presentation pathways provides crucial insights for the design of next-generation vaccines and therapeutic strategies capable of restoring robust antiviral immunity. 展开更多
关键词 Adaptive immunity suppression Antigen presentation Classical swine fever Immune evasion Macrophages Dendritic cells
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Point-of-care antigen detection for porcine deltacoronavirus:Colloidal gold and fluorescent immunochromatographic test strips 认领 引用
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作者 Zezhao Cao Junchao Shi +9 位作者 Ruijie Hu Jun Xue Gaili Wang Zi Li Huabo Yu Wei Liu Wenqi He Hualei Wang Haili Zhang Yungang Lan 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第1期394-397,共4页
Highlights By conjugating the same anti-N monoclonal antibody(mAb4-mAb1)with colloidal gold or fluorescent microspheres,this study developed two rapid point-of-care antigen immunochromatographic strips for the detecti... Highlights By conjugating the same anti-N monoclonal antibody(mAb4-mAb1)with colloidal gold or fluorescent microspheres,this study developed two rapid point-of-care antigen immunochromatographic strips for the detection of porcine deltacoronavirus.The fluorescent microsphere-based lateral flow test strip demonstrated a sensitivity of 101.7TCID50/0.1 mL,which is fourfold higher than that of the colloidal gold-based assay.Porcine deltacoronavirus(PDCoV)is a recently identified enteric coronavirus that causes an acute infectious disease in piglets,leading to diarrhea,vomiting,dehydration,and mortality(Hu et al.2015). 展开更多
关键词 enteric coronavirus point care antigen detection fluorescent microspheresthis immunochromatographic strips porcine deltacoronavirusthe fluorescent immunochromatographic test strips colloidal gold porcine deltacoronavirus
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Prevalence of hepatitis-D virus in hepatitis B surface antigenpositive patients of India:A meta-analysis(research on behalf of ESGVH) 认领 引用
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作者 Nitu Mishra Anish Gupta +11 位作者 Ashutosh K Singh Juhi Nagar Ashish K Vyas Vikas Yadav Greeshma C Ravindran Megha K Pandey Irfan F Corovic Uday Mandal Rajnarayan R Tiwari Pradyumna K Mishra Sumit K Rawat Ram K Nema 《World Journal of Gastroenterology》 SCIE CAS 2026年第21期123-134,共12页
BACKGROUND Hepatitis D virus(HDV)infection accelerates liver disease progression in individuals with hepatitis B virus(HBV)infection,yet its true burden in India remains unclear.HDV depends on HBV for replication and ... BACKGROUND Hepatitis D virus(HDV)infection accelerates liver disease progression in individuals with hepatitis B virus(HBV)infection,yet its true burden in India remains unclear.HDV depends on HBV for replication and is associated with rapid fibrosis,early cirrhosis,and increased hepatocellular carcinoma risk,making accurate prevalence estimates essential for clinical management and public health planning in endemic settings.AIM To estimate the pooled prevalence of HDV among hepatitis B surface antigen(HBsAg)-positive individuals in India and assess regional and methodological variations to inform national hepatitis control strategies.METHODS We systematically searched PubMed,Scopus,and Web of Science from inception to December 31,2024 for studies reporting HDV prevalence in HBsAg-positive individuals in India,using laboratory-confirmed diagnosis.Eligible cross-sectional,cohort,or case-control studies were assessed for methodological quality using the Joanna Briggs Institute checklist.Pooled prevalence was calculated using a random-effects generalized linear mixed model with logit transformation.Heterogeneity was quantified with I2 statistics,and publication bias was assessed by funnel plot inspection,Begg’s,and Egger’s tests.RESULTS Thirty studies,comprising a total of 5365 HBsAg-positive participants from multiple regions in India,met inclusion criteria.The pooled HDV prevalence was 5.05%(95%confidence interval:2.37-10.41;I2=93.5%,P<0.0001),with reported rates ranging from 0%to 91.7%.Heterogeneity appeared related to study setting,population risk profile,diagnostic method,and geographic location.Begg’s test showed no significant asymmetry(P=0.57),while Egger’s test indicated possible small-study effects(P=0.006).CONCLUSION HDV co-infection affects approximately 5%of HBV carriers in India,representing a significant public health concern.Routine HDV screening,prioritization of high-burden regions,expansion of diagnostic capacity,and sustained HBV vaccination coverage are critical to reducing disease impact.Regional and population-based variation demands urgent implementation of standardized HDV testing protocols and targeted public health interventions in high-burden areas. 展开更多
关键词 Hepatitis D virus Hepatitis B surface antigen Prevalence Co-infection Epidemiology Public health Risk factors
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Baseline hepatitis B surface antigen and cirrhosis predict extended interferon therapy in chronic hepatitis B:A retrospective study 认领 引用
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作者 Fei Yan Xiu-Lan Xue +20 位作者 Ying Guo Qi-Ran Zhang Rui-Rui You Jia Shang Xiao-Ping Wu Jia-Wei Geng Xiao-Hong Gao Qing Ye Jing Liang Xiao-Yan Wang Jian-Yong Zeng Jing Chen Yi-Cheng Lin Xin-Yu Chen Qin Du Wei-Li Yin Lei Liu Fang Wang Bai-Guo Xu Wen-Hong Zhang Hui-Ling Xiang 《World Journal of Gastroenterology》 SCIE CAS 2026年第12期62-76,共15页
BACKGROUND Chronic hepatitis B(CHB)is a major global health burden,with China being the most affected.Achieving a clinical cure,defined as hepatitis B surface antigen(HBsAg)clearance,is the ideal treatment endpoint.Wh... BACKGROUND Chronic hepatitis B(CHB)is a major global health burden,with China being the most affected.Achieving a clinical cure,defined as hepatitis B surface antigen(HBsAg)clearance,is the ideal treatment endpoint.While a 48-week interferon course is standard,extended therapy may improve HBsAg clearance rates.However,there exists a notable gap in predictive modeling studies concerning extended treatment courses(≥48 weeks).AIM To develop a predictive model for identifying patients who require extended interferon therapy(≥48 weeks)for HBsAg clearance.METHODS This multicenter retrospective study included CHB patients,including those with compensated cirrhosis,who achieved HBsAg clearance(HBsAg<0.05 IU/mL)following treatment with pegylated interferon alpha-2b,either alone or in combination with nucleoside analogs.After propensity score matching,we employed least absolute shrinkage and selection operator(LASSO)regression and multivariate regression to identify independent predictors.RESULTS A total of 688 eligible patients with CHB were enrolled in this study.After propensity score matching at a 1:1 ratio,375 patients remained,including 196 in the training cohort.Among the training cohort,36(18.37%)were classified in the extended course(≥48 weeks)and 160(81.63%)in the regular course(<48 weeks).LASSO and multivariate regression analyses identified baseline HBsAg and cirrhosis as significant risk factors for extended interferon therapy.The model demonstrated strong discriminatory ability,with the area under the curve of 0.83[95%confidence interval(CI):0.76-0.91]for the training cohort and 0.81(95%CI:0.71-0.90)for the externally validated cohort.The model’s predictive efficacy was not influenced by subgroup characteristics.CONCLUSION This study successfully constructed and validated a prediction model based on baseline HBsAg and cirrhosis to identify potential populations that may benefit from extended interferon therapy(≥48 weeks). 展开更多
关键词 Chronic hepatitis B Clinical cure Extended course of interferon Hepatitis B surface antigen Prediction model
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Early postoperative negative conversion of Helicobacter pylori stool antigen after distal gastrectomy and potential host-related factors 认领 引用
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作者 Gerelt-Od Khenmedekh Dae Hoon Kim +1 位作者 Dong Hee Ryu Kwon Cheol Yoo 《World Journal of Gastroenterology》 SCIE CAS 2026年第28期46-54,共9页
BACKGROUND The early postoperative behavior of Helicobacter pylori(H.pylori)after distal gastrectomy(DG)and the host factors influencing early negative conversion remain poorly defined.In this study,we evaluated early... BACKGROUND The early postoperative behavior of Helicobacter pylori(H.pylori)after distal gastrectomy(DG)and the host factors influencing early negative conversion remain poorly defined.In this study,we evaluated early postoperative H.pylori dynamics using a standardized stool antigen test(SAT).AIM To evaluate early postoperative H.pylori dynamics and identified clinicopathological factors associated with early negative conversion.METHODS Among 129 patients who underwent DG for gastric cancer,53 had active preoperative H.pylori infection,as confirmed by SAT.Postoperative status was reassessed at 3 months,and patients were categorized into the persistent infection(n=13)or spontaneous negative conversion(n=40)group.Clinicopathological variables were compared between groups.Multivariable logistic regression was performed,and sensitivity analyses included Firth penalized logistic regression.A post hoc power analysis was conducted to contextualize the sample size.RESULTS Early negative conversion on SAT occurred in 75.5%of the patients at 3 months.The early negative conversion group had a higher preoperative American Society of Anesthesiologists(ASA)score than the persistent infection group(2.10±0.67 vs 1.69±0.48;P=0.024).In the primary multivariable model adjusting for age,body mass index,sex,and postoperative antibiotic use,a higher ASA score was directionally association with early negative conversion(odds ratio=3.02;95%CI:0.91-10.01;P=0.071).Sensitivity analyses using penalized likelihood and models incorporating serum albumin and hemoglobin produced directionally consistent estimates with wide confidence intervals.Post-hoc power analysis indicated limited statistical power(approximately 0.44)to detect an independent association with the current sample size.CONCLUSION A higher ASA score may be associated with early negative conversion after DG;however,the findings are exploratory and require validation in larger cohorts with longitudinal follow-up to confirm durable eradication. 展开更多
关键词 Helicobacter pylori Distal gastrectomy Gastric cancer Stool antigen test American Society of Anesthesiologists score Negative conversion
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The Efficacy and Safety of B-Cell Maturation Antigen(BCMA)Antibody-Drug Conjugates(ADC)in Development against Cancer:A Systematic Review 认领 引用
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作者 Jing Shan Catherine King +1 位作者 Harunor Rashid Veysel Kayser 《Oncology Research》 SCIE 2026年第1期1-22,共22页
Objectives:B-cell maturation antigen(BCMA)-targeted antibody–drug conjugates(ADCs)have emerged as promising therapies for relapsedefractory multiple myeloma(RRMM),but the overall efficacy and safety profile is unclea... Objectives:B-cell maturation antigen(BCMA)-targeted antibody–drug conjugates(ADCs)have emerged as promising therapies for relapsedefractory multiple myeloma(RRMM),but the overall efficacy and safety profile is unclear.This study aimed to synthesize the available evidence on the safety and efficacy of BCMA-ADCs in development for RRMM.Methods:A systematic search was conducted using six bibliographic databases and ClinicalTrials.gov up to November 2024.Studies were eligible if they were human clinical trials or animal studies evaluating BCMA-ADCs and reported efficacy and safety outcomes.Data extraction and quality assessments were conducted using validated tools,including ROBINS-I and SYRCLE’s risk of bias tool.Results:A total of 21 studies were included:16 clinical trials and five animal studies.Key findings included that belantamab mafodotin demonstrated variable but generally durable response rates(32%–85%)and a broad range of progression-free survival(PFS)(2.8–36.6 months),albeit with ocular toxicities in 51%–96%.Among newer candidates,MEDI2228 showed median PFS 5.1–6.6 months with 14%discontinuation for ocular symptoms,while AMG 224 had an overall response rate(ORR)of 23%(9/40)with anemia 21%,thrombocytopenia 24%,and ocular adverse events(AEs)21%.Animal studies supported the tumor-eradicating potential of all BCMA-ADC candidates,although safety signals such as hepatic and renal toxicity were noted with HDP-101.The risk of bias assessment revealed generally moderate to serious concerns in human trials,while the overall quality of the animal studies was acceptable.Conclusions:BCMA-targeted ADC candidates show encouraging efficacy in RRMM,particularly belantamab mafodotin.However,frequent AEs,especially ocular and hematologic toxicities,underscore the need for optimization in ADC design.Further research should prioritize enhancing safety while maintaining clinical benefit. 展开更多
关键词 B-cell maturation antigen antibody drug conjugates multiple myeloma belantamab mafodotin ocular toxicity clinical trials
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Antigen presentation at the brain barriers in multiple sclerosis 认领 引用
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作者 Joshua Brands Jeroen Bogie Bieke Broux 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期2932-2933,共2页
Loss of immune tolerance to central nervous system(CNS)antigens lies at the heart of multiple sclerosis(MS),the most common chronic autoimmune disease of the CNS.MS affects nearly2 million people wo rldwide and is cha... Loss of immune tolerance to central nervous system(CNS)antigens lies at the heart of multiple sclerosis(MS),the most common chronic autoimmune disease of the CNS.MS affects nearly2 million people wo rldwide and is chara cterized by focal areas of demyelination,inflammation,axonal injury,and neurodegeneration(Bronge et al.,2022;Magliozzi et al.,2023). 展开更多
关键词 brain barriers central nervous system antigen presentation multiple sclerosis loss immune tolerance loss immune multiple sclerosis ms chronic autoimmune disease
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Prostate specific membrane antigen(PSMA)as a biomarker in early and localized advanced prostate cancer:a narrative review 认领 引用
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作者 Jonathon Carll Jacinta Bonaddio +3 位作者 DixonWoon Marlon Perera Nathan Lawrentschuk Thilakavathi Chengodu 《The Canadian Journal of Urology》 SCIE 2026年第1期21-34,共14页
Prostate-specific membrane antigen(PSMA)is a surface membrane antigen that is highly overexpressed in prostate cancer,with heterogenous expression throughout the natural history of the disease.This has generated signi... Prostate-specific membrane antigen(PSMA)is a surface membrane antigen that is highly overexpressed in prostate cancer,with heterogenous expression throughout the natural history of the disease.This has generated significant interest as a potential biomarker for use in early diagnosis and treatment of prostate cancer.We reviewed the literature surrounding PSMA and its current clinical applications in diagnosing and managing early prostate cancer that is confined to the prostate and local lymph nodes.A search on PubMed,Medline,and Web of Science was performed using the following keywords:“PSMA”,“Prostate Specific Membrane Antigen”,“Prostate cancer”,“Biomarker”,“Diagnosis”.We considered all available articles relevant to the topic of PSMA as a biomarker in early prostate cancer when developing this narrative review.Key articles assessing the biology of PSMA,as well as its use as a potential diagnostic and therapeutic target in early prostate cancer,were assessed.The role of PSMA PET as a potential diagnostic and risk stratification tool was assessed.The current use of antibody-drug conjugates and radioligand therapy targeting PSMA was assessed,along with any current evidence to support their use in early prostate cancer.PSMA is heavily expressed throughout the early stages of prostate cancer,and this has significant therapeutic implications.There is a growing body of evidence that shows PSMA PET can play a role in the diagnosis,risk stratification,and prognostication of localised prostate cancer.PSMA-targeted therapies such as Lu-177 currently do not have any proven benefit in treating early prostate cancer;however,this remains an area of ongoing research. 展开更多
关键词 prostate specific membrane antigen(PSMA) positron emission tomography(PET) radioligand therapy prostate cancer
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Emerging Chimeric Antigen Receptor-Immune Cell Therapy for Pancreatic Cancer:Mechanisms,Clinical Advances,and Future Perspectives 认领 引用
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作者 Shuo Wang Miao Wang Wei Yao 《Oncology Research》 SCIE 2026年第4期259-301,共43页
Pancreatic ductal adenocarcinoma(PDAC)remains one of the most lethal malignancies,characterized by a highly immunosuppressive tumor microenvironment(TME),dense stromal architecture,and limited response to conventional... Pancreatic ductal adenocarcinoma(PDAC)remains one of the most lethal malignancies,characterized by a highly immunosuppressive tumor microenvironment(TME),dense stromal architecture,and limited response to conventional therapies.This review comprehensively examines the emerging role of chimeric antigen receptor(CAR)-engineered immune cells,including chimeric antigen receptor-T(CAR-T),CAR-macrophages(CAR-M),and CAR-natural killer(CAR-NK)cells,as innovative immunotherapeutic strategies for PDAC.We delve into the mechanistic foundations of these platforms,highlighting their unique abilities to target tumor-associated antigens,overcome stromal barriers,and remodel the immunosuppressive TME.Recent preclinical and clinical advances demonstrate promising antitumor activity,particularly with targets such as mesothelin,claudin18.2,and human epidermal growth factor 2(HER2),though challenges related to antigen heterogeneity,TME suppression,and cell persistence remain.We further discuss synergistic approaches involving genetic engineering,microenvironment modulation,and combination therapies aimed at enhancing efficacy.Finally,we offer perspectives on the future direction of CARbased therapies,including the development of next-generation constructs,allogeneic“off-the-shelf”products,and personalized combination regimens,underscoring their potential in pancreatic cancer. 展开更多
关键词 Chimeric antigen receptor pancreatic cancer immune cell therapy immunotherapy clinical trial
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Clinical prediction of carcinoembryonic antigen combined with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for postoperative survival in colorectal cancer 认领 引用
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作者 Tao Wang Chang Liu Jun Jiang 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第4期126-134,共9页
BACKGROUND Colorectal cancer(CRC)presents a significant global health burden,with considerable variation in survival following curative surgery.Identifying patients at high risk of poor outcomes is crucial for tailore... BACKGROUND Colorectal cancer(CRC)presents a significant global health burden,with considerable variation in survival following curative surgery.Identifying patients at high risk of poor outcomes is crucial for tailored treatment and surveillance strategies.Evidence indicates that individual prognostic markers,whether tumor-associated or inflammation-based,offer limited predictive value.This study posits that a combined model integrating carcinoembryonic antigen(CEA),neutrophil-to-lymphocyte ratio(NLR),and platelet-to-lymphocyte ratio(PLR)will provide a more accurate and robust prediction of postoperative survival in patients with CRC than any single biomarker alone.AIM To evaluate the prognostic value of combined CEA,NLR,and PLR in CRC.METHODS This study retrospectively enrolled 120 CRC patients who underwent radical resection from July 2021 to July 2022.Based on three-year survival status,patients were classified into a mortality group(43 patients)and a survival group(77 patients).Baseline NLR,PLR,and CEA levels were compared between groups.Cox proportional hazards regression and receiver operating characteristic curve analyses were used to identify survival risk factors and evaluate prognostic utility.RESULTS Among 120 patients,43 died within 3 years postoperatively,yielding a mortality rate of 35.83%.Comparing clinical data between groups,the deceased group displayed significantly higher serum levels of NLR,PLR,and CEA than the surviving group,along with a higher proportion of tumors>5 cm in diameter and distant metastases(P<0.05).Cox regression analysis demonstrated that elevated postoperative serum NLR,PLR,and CEA levels constitute risk factors for postoperative survival in CRC patients.Receiver operating characteristic curve analysis revealed that the area under the curve for predicting postoperative survival using NLR,PLR,and CEA individually were 0.896,0.805,and 0.880,correspondingly.The integrated area under the curve for the three biomarkers was 0.977,indicating significantly higher predictive value than any single marker(P<0.0001).CONCLUSION Combined assessment of inflammatory markers NLR,PLR and tumor marker CEA provides valuable prognostic information for CRC patient survival. 展开更多
关键词 Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Carcinoembryonic antigen Colorectal cancer Postoperative survival Predictive value
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