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Fermented rice milk ameliorates atopic dermatitis in mice via MAPK and NF-κB signaling pathway 认领 引用
1
作者 Zhiyong Mu Yijin Yang +4 位作者 Yongjun Xia Shen Li Guangqiang Wang Xin Song Lianzhong Ai 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第2期739-749,共11页
Atopic dermatitis(AD),which is associated with inflammatory response and skin damage,is increasing worldwide in recent years.Interest is increasing in the protective effects of natural and fermented products on the pr... Atopic dermatitis(AD),which is associated with inflammatory response and skin damage,is increasing worldwide in recent years.Interest is increasing in the protective effects of natural and fermented products on the prevention and treatment of AD.This study aimed to investigate the ameliorative effects of a new rice milk product fermented with Saccharomyces cerevisiae on AD mice.Fermented rice milk could effectively attenuated the symptoms of AD mice,such as skin lesions,scaliness and lichenification.Furthermore,fermented rice milk decreased the levels of inflammatory cytokines interleukin(IL)-4,IL-6 and tumor necrosis factor(TNF)-αin 2,4-dinitrochlorobenzene(DNCB)induced mice.It was also observed that fermented rice milk treatment downregulated the levels of p-IKBα,p-NF-κB,p-ERK,p-JNK and p-p38 proteins expression in skin of AD mice,which showed the anti-inflammatory function of fermented rice milk,mainly via the NF-κB and MAPK signaling pathways.In addition,S.cerevisiae fermentation reduced original flavor of rice milk,and increased the acid and alcohol compounds.Overall,the findings indicated that S.cerevisiae fermentation improved the flavor characteristics of rice milk,and fermented rice milk exhibited protective effects against DNCB-induced atopic dermatitis by downregulating NF-κB and MAPK signaling pathways and protecting the skin barrier. 展开更多
关键词 Saccharomyces cerevisiae Rice milk Volatile flavor Atopic dermatitis Intestinal barrier
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Janus kinase inhibitors enhance the efficacy of dupilumab in refractory atopic dermatitis 认领 引用
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作者 YAN Siyu YANG Haixiang +3 位作者 LU Jianyun WU Ruoya JIANG Yutong GAO Lihua 《中南大学学报（医学版）》 CAS CSCD 北大核心 2026年第4期808-815,共8页
Objective:Patients with moderate-to-severe atopic dermatitis(AD)often experience intense pruritus and extensive skin lesions,which markedly impair quality of life.Current treatment options,including biologics and smal... Objective:Patients with moderate-to-severe atopic dermatitis(AD)often experience intense pruritus and extensive skin lesions,which markedly impair quality of life.Current treatment options,including biologics and small-molecule agents,may provide limited efficacy and are associated with adverse effects.For patients who respond inadequately to dupilumab,particularly those with insufficient control of pruritus,more effective therapeutic strategies are needed.This study aims to evaluate the efficacy,safety,and clinical value of combining dupilumab with Janus kinase inhibitors(JAKis)in the treatment of refractory AD.Methods:This retrospective study assessed the efficacy and safety of combination therapy with dupilumab and JAKis in 7 patients with refractory moderate-to-severe AD.Patients received either abrocitinib(100 mg/d)or upadacitinib(15 mg/d)in combination with dupilumab.Disease severity before and after combination therapy was evaluated using the Eczema Area and Severity Index(EASI),Scoring Atopic Dermatitis(SCORAD),Patient-Oriented Eczema Measure(POEM),Dermatology Life Quality Index(DLQI),Itch Numerical Rating Scale(Itch-NRS),and Sleep Disorder Numerical Rating Scale(Sleep-NRS).Adverse events were also recorded.Results:After 4 weeks of combination therapy,patients with AD who had shown an inadequate response to dupilumab monotherapy exhibited marked improvement in skin lesions.Significant reductions were observed in EASI,SCORAD,POEM,DLQI,Itch-NRS,and Sleep-NRS scores(all P<0.05).All patients achieved an EASI50(defined as≥50%reduction in EASI score from baseline)criteria.No serious adverse events were reported,except for one case of mild acne.Conclusion:In patients with AD who show an inadequate response to continued dupilumab treatment,the addition of JAKis can significantly enhance therapeutic efficacy and is generally well tolerated.This combination regimen may represent a promising treatment option for refractory AD. 展开更多
关键词 Janus kinase inhibitors atopic dermatitis dupilumab abrocitinib upadacitinib combination therapy
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Clinical practice essentials of Expert consensus on nonpharmacological interventions for atopic dermatitis in children 认领 引用
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作者 Limin Dou Jianbo Wang +1 位作者 Yunqing REN Ming LI 《临床儿科杂志》 CAS CSCD 北大核心 2026年第5期394-398,共5页
Atopic dermatitis(AD)is a chronic,relapsing inflammatory skin disorder that is highly prevalent in children.Because of its pathogenesis and clinical heterogeneity,exclusive use of pharmacological treatment cannot achi... Atopic dermatitis(AD)is a chronic,relapsing inflammatory skin disorder that is highly prevalent in children.Because of its pathogenesis and clinical heterogeneity,exclusive use of pharmacological treatment cannot achieve the optimal control of AD.This consensus therefore endorses non-pharmacological interventions as essential components of comprehensive AD management.The recommendations emphasize the avoidance of environmental triggering factors,the maintenance and restoration of skin barrier homeostasis via structured skincare,and the implementation of patient/caregiver education and psychological support.These measures aim not only to reduce relapse frequency and extent clinical remissions,but also to improve the quality of life for patients and caregivers.The consensus offers four core recommendations:(1)Non-pharmacological interventions should be employed as primary management strategies across the spectrum of AD severity,from mild to severe disease.(2)Effectiveness of the interventions should be assessed through clinical and medical evaluation,with supplemental objective or laboratory measurements when feasible.(3)Primary interventions include systematic avoidance of environmental triggers,regular application of skin care,and structured programs for education and psychological support.(4)Non-pharmacological strategies are applicable at all stages of disease,from prevention to active flares and clinical remissions. 展开更多
关键词 skin barrier pharmacological treatment avoidance environmental triggering factorsthe children atopic dermatitis ad atopic dermatitis skin disorder maintenance restoration skin barrier homeostasis
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Investigating the potential mechanisms of Wenqing Yin against atopic dermatitis based on network pharmacology,experimental pharmacology,and molecular docking 认领 引用
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作者 Yi Wang Zhen Liu +3 位作者 Si-Man Li Lin Lin Wei Dai Meng-Yue Ren 《Traditional Medicine Research》 2026年第2期1-11,共11页
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o... Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4+and CD8+cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4+/CD8+cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4+and CD8+cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses. 展开更多
关键词 Wenqing Yin atopic dermatitis mouse model UPLC-Orbitrap-MS/MS network pharmacology
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Atopic dermatitis management in the era of integrative medicine 认领 引用
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作者 Min Chen Wan-qing Liao 《Journal of Integrative Medicine》 SCIE CAS CSCD 2026年第2期137-139,共3页
Atopic dermatitis(AD)is the most common chronic inflammatory skin condition.It has significant socioeconomic consequences and complex pathophysiology,necessitating updated management guidelines that consider the age,s... Atopic dermatitis(AD)is the most common chronic inflammatory skin condition.It has significant socioeconomic consequences and complex pathophysiology,necessitating updated management guidelines that consider the age,sex and geographic location of patients.Despite the widespread use of Western medicine(WM),including topical corticosteroids,as the primary treatment for AD,the possible negative effects of WM therapies are inescapable.Although there is still a lack of strong evidence,the integration of traditional Chinese medicine(TCM)with WM may yield a more favorable therapeutic response for AD than WM alone,due to the synergistic effects involved.Balancing the application of diagnostic and therapeutic approaches from TCM and WM is crucial for the management of AD,enhancing treatment efficacy for patients,and averting disease recurrence.In 2025,a new clinical guideline for the diagnosis and treatment of AD was released;it emphasized the integration of TCM with WM.This guideline is crucial as it consolidates global expertise and data to provide a standardized framework for the practical integration of techniques to bridge divides among clinical disciplines.As more substantial data emerge,the development and enhancement of integrative medicine for AD management should be prioritized globally,particularly in Asian regions. 展开更多
关键词 Atopic dermatitis Medicine,traditional Chinese Integrative medicine
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Comparing lebrikizumab with other systemic immunomodulators for moderate to severe atopic dermatitis:An updated systematic review 认领 引用
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作者 Chris Alphonse Muhammad Irfan +10 位作者 Sergio Camilo Torres Céspedes Chisom Nwanejuafor Kashfia Nayeem Elias Hertan Vrinda Mohan Haripriya Gupta Noor Ul Ain Fatima Luis Adrian Guadarrama Mendoza Azkah Sardar Alexander Michael Diaz Inshal Jawed 《World Journal of Clinical Cases》 2026年第12期12-26,共15页
BACKGROUND Atopic dermatitis(AD)is a long-term inflammatory skin disease that requires prolonged management with systemic therapy.Treatment with lebrikizumab results in apoptosis of effector T helper 2 cells that prod... BACKGROUND Atopic dermatitis(AD)is a long-term inflammatory skin disease that requires prolonged management with systemic therapy.Treatment with lebrikizumab results in apoptosis of effector T helper 2 cells that produce interleukin-13.AIM To conduct a systematic literature review on the comparative efficacy of lebrikizumab monotherapy vs other approved biologics and the short-term efficacy of Janus kinase inhibitors in moderate-to-severe AD in adults and adolescents.METHODS A systematic database search was conducted to identify randomized,double-blind,placebo-controlled phase 2 and phase 3 trials of lebrikizumab,dupilumab,tralokinumab,abrocitinib,baricitinib,and upadacitinib used as monotherapy,from database inception through December 2025.Efficacy measurements comprised Eczema Area and Severity Index(EASI)responses,Investigator Global Assessment(IGA)0/1,and pruritus Numeric Rating Scale improvements.Two independent reviewers screened studies,and inter-reviewer agreement was assessed using Cohen's kappa statistic.The Cochrane Risk of Bias tool and the Grading of Recommendations Assessment,Development and Evaluation system assessed the quality of the evidence,with data extraction performed by independent reviewers.RESULTS A total of 28 studies with 10847 patients were evaluated(22 from the previous review and six new studies).The level of agreement among reviewers for study selection was substantial,with a kappa statistic of 0.89.Dosing intervals are reported as every 2 weeks(Q2W).According to 22 trials of network meta-analysis,lebrikizumab 250 mg Q2W was as effective as dupilumab 300 mg Q2W for IGA 0/1.There was an equal improvement in EASI and itch score at weeks 12-16.Lebrikizumab was more efficacious than tralokinumab and baricitinib on outcomes.A total of 2316 patients were included in six new studies designed to confirm these results in real-world evidence settings 2024-2025,with EASI-75 and IGA 0/1 response rates of 65%-78%and 58%-72%,respectively.Data on a two-year extension demonstrated sustained efficacy and acceptable safety.The risk of bias generally resulted in moderate-quality evidence.CONCLUSION An updated review of 28 studies shows that lebrikizumab is at least as efficacious as dupilumab and more efficacious than tralokinumab in moderate-to-severe AD.There is real-world and long-term data to support its first-line use with moderate to high certainty,but complete,736 trials,head-to-head trials,and biomarker research remain needed. 展开更多
关键词 Atopic dermatitis Lebrikizumab Dupilumab Tralokinumab Janus kinase inhibitors Systematic review Network meta-analysis Grading of Recommendations Assessment,Development and Evaluation assessment
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Clinical practice guidelines for the diagnosis and treatment of atopic dermatitis with integrative traditional Chinese and Western medicine 认领 引用 被引量：2
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作者 Xin-ran Du Meng-yi Wu +13 位作者 Mao-can Tao Ying Lin Chao-ying Gu Min-feng Wu Yi Cao Da-can Chen Wei Li Hong-wei Wang Ying Wang Yi Wang Han-zhi Lu Xin Liu Xiang-fei Su Fu-lun Li 《Journal of Integrative Medicine》 SCIE CAS CSCD 2025年第6期641-653,共13页
Traditional Chinese medicine(TCM)is a well-accepted therapy for atopic dermatitis(AD).However,there are currently no evidence-based guidelines integrating TCM and Western medicine for the treatment of AD,limiting the ... Traditional Chinese medicine(TCM)is a well-accepted therapy for atopic dermatitis(AD).However,there are currently no evidence-based guidelines integrating TCM and Western medicine for the treatment of AD,limiting the clinical application of such combined approaches.Therefore,the China Association of Chinese Medicine initiated the development of the current guideline,focusing on key issues related to the use of TCM in the treatment of AD.This guideline was developed in accordance with the principles of the guideline formulation manual published by the World Health Organization.A comprehensive review of the literature on the combined use of TCM and Western medicine to treat AD was conducted.The findings were extensively discussed by experts in dermatology and pharmacy with expertise in both TCM and Western medicine.This guideline comprises 23 recommendations across seven major areas,including TCM syndrome differentiation and classification of AD,principles and application scenarios of TCM combined with Western medicine for treating AD,outcome indicators for evaluating clinical efficacy of AD treatment,integration of TCM pattern classification and Western medicine across disease stages,daily management of AD,the use of internal TCM therapies and proprietary Chinese medicines,and TCM external treatments. 展开更多
关键词 Atopic dermatitis Clinical practice guidelines Integrative medicine Traditional Chinese medicine Evidence-based medicine
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Prim-O-glucosylcimifugin mitigates atopic dermatitis by inhibiting Th2 differentiation through LCK phosphorylation modulation 认领 引用 被引量：1
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作者 Hang Zhao Xin Ma +8 位作者 Hao Wang Xiao-jie Ding Le Kuai Jian-kun Song Zhan Zhang Dan Yang Chun-jie Gao Bin Li Mi Zhou 《Journal of Integrative Medicine》 SCIE CAS CSCD 2025年第3期309-319,共11页
Objective:To assess the safety and topical efficacy of prim-O-glucosylcimifugin(POG)and investigate the molecular mechanisms of its therapeutic effects in atopic dermatitis(AD).Methods:The effects of POG on human kera... Objective:To assess the safety and topical efficacy of prim-O-glucosylcimifugin(POG)and investigate the molecular mechanisms of its therapeutic effects in atopic dermatitis(AD).Methods:The effects of POG on human keratinocyte cell viability and its anti-inflammatory properties were evaluated using cell counting kit-8 assay and reverse transcription-quantitative polymerase chain reaction(RT-qPCR).Subsequently,the impact of POG on the differentiation of cluster of differentiation(CD)4~+T cell subsets,including T-helper type(Th)1,Th2,Th17,and regulatory T(Treg),was examined through in vitro experiments.Network pharmacology analysis was used to elucidate POG's therapeutic mechanisms.Furthermore,the therapeutic potential of topically applied POG was further evaluated in a calcipotriol-induced mouse model of AD.The protein and transcript levels of inflammatory markers,including cytokines,lymphocyte-specific protein tyrosine kinase(Lck)mRNA,and LCK phosphorylation(p-LCK),were quantified using immunohistochemistry,RT-qPCR,and Western blot analysis.Results:POG was able to suppress cell proliferation and downregulate the transcription of interleukin 4(Il4)and Il13 mRNA.In vitro experiments indicated that POG significantly inhibited the differentiation of Th2 cells,whereas it exerted negligible influence on the differentiation of Th1,Th17 and Treg cells.Network pharmacology identified LCK as a key therapeutic target of POG.Moreover,the topical application of POG effectively alleviated skin lesions in the calcipotriol-induced AD mouse models without causing pathological changes in the liver,kidney or spleen tissues.POG significantly reduced the levels of Il4,Il5,Il13,and thymic stromal lymphopoietin(Tslp)m RNA in the AD mice.Concurrently,POG enhanced the expression of p-LCK protein and Lck mRNA.Conclusion:Our research revealed that POG inhibits Th2 cell differentiation by promoting p-LCK protein expression and hence effectively alleviates AD-related skin inflammation. 展开更多
关键词 Atopic dermatitis Lymphocyte-specific protein tyrosine kinase Prim-O-glucosylcimifugin Th2 differentiation Inflammation
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Risk factors for anxiety and depression in patients with atopic dermatitis and their impact on prognosis 认领 引用 被引量：1
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作者 Kun Liu Wei Gao +1 位作者 Hong-Guang Lu Zhao-Gui Chen 《World Journal of Psychiatry》 SCIE 2025年第6期139-148,共10页
BACKGROUND Atopic dermatitis(AD)is a chronic inflammatory skin disease characterized by visible lesions that can lead to anxiety and depression.These psychological impacts may severely affect the physical and mental h... BACKGROUND Atopic dermatitis(AD)is a chronic inflammatory skin disease characterized by visible lesions that can lead to anxiety and depression.These psychological impacts may severely affect the physical and mental health and the overall quality of life of the affected individuals.AIM To identify the risk factors for anxiety and depression among patients with AD and to assess their influence on prognosis.METHODS A cross-sectional study was conducted in 273 patients with AD who visited Shanghai Jinshan Tinglin Hospital between July 2021 and June 2023.Data were collected using standardized instruments,including the general information questionnaire,hospital anxiety and depression scale,scoring AD index,and dermatology life quality index.RESULTS Among the evaluated patients,24.5%had symptoms of anxiety,and 19.8%had symptoms of depression.Independent risk factors for anxiety included lower education level[odds ratio(OR)=0.338,95%confidence interval(CI):0.183-0.625],increased number of medical visits(OR=2.300,95%CI:1.234-4.255),sleep disorders(OR=2.013,95%CI:1.032-3.923),and allergic rhinitis(OR=2.052,95%CI:1.097-3.839).Factors for depression included more severe pruritus(OR=6.837,95%CI:1.330-35.132),higher number of medical visits(OR=2.979,95%CI:1.430-6.205),sleep disorders(OR=2.245,95%CI:1.033-5.024),and asthma(OR=2.208,95%CI:1.003-4.859).Dermatology life quality index scores correlated positively with anxiety,depression,scoring AD index,sleep disorders,number of visits,and intensity of pruritus(P<0.05).CONCLUSION In patients with AD,anxiety and depression are associated with educational level,frequency of medical visits,sleep disorders,allergic rhinitis,pruritus,and asthma,all of which exacerbate symptoms and reduce quality of life. 展开更多
关键词 Atopic dermatitis Anxiety Depression Pruritus Sleep disorder Quality of life
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Modulatory role of vitamin D in atopic dermatitis and allergic rhinitis 认领 引用 被引量：1
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作者 Chandra Sekhar Devulapalli 《World Journal of Clinical Pediatrics》 2025年第4期189-195,共7页
Vitamin D,beyond its classical role in calcium homeostasis,has emerged as a key regulator of immune function and epithelial barrier integrity.Its deficiency during early childhood—a critical period for immune maturat... Vitamin D,beyond its classical role in calcium homeostasis,has emerged as a key regulator of immune function and epithelial barrier integrity.Its deficiency during early childhood—a critical period for immune maturation—has been increasingly implicated in the development of atopic diseases.While extensively studied in asthma,its role in non-respiratory allergic conditions such as atopic dermatitis(AD)and allergic rhinitis(AR)remains comparatively underexplored.This minireview synthesizes current mechanistic and clinical evidence on vitamin D in pediatric AD and AR.In AD,vitamin D promotes epidermal barrier function through upregulation of filaggrin and ceramide synthesis,and enhances antimicrobial defense via induction of antimicrobial peptides.Observational studies consistently report lower serum 25-hydroxyvitamin D in affected children,particularly those with allergic sensitization.Select randomized controlled trials suggest clinical improvement with supplementation,especially at doses>2000 IU/day in deficient individuals.In AR,epidemiological data indicate stronger inverse associations with seasonal(pollen-induced)disease.Proposed mechanisms include modulation of dendritic cells,regulatory T cells,T helper 2 cytokines,and mucosal barrier integrity.The shared immunopathogenesis of AD and AR underscores vitamin D’s relevance.Although promising,clinical evidence remains heterogeneous.Future research should prioritize phenotype-stratified trials to clarify optimal dosing,timing,and individual response determinants,including genetics and microbiome composition. 展开更多
关键词 Vitamin D Atopic dermatitis Allergic rhinitis Pediatric allergy Immune modulation Epithelial barrier function Vitamin D receptor Allergic sensitization Earlylife immunity Genetic polymorphism
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Mannan Oligosaccharides Improve Atopic Dermatitis and Its Psychological Comorbidities 认领 引用
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作者 NIE Tingting CHEN Yue +5 位作者 TANG Liu CHEN Shaoze FANG Mingyu FANG Zhenfeng SHI Lu CAO Xiaoqin 《食品科学》 EI CAS CSCD 北大核心 2025年第18期155-168,共14页
Objective:This study aimed to investigate the association of atopic dermatitis(AD)and anxiety/depression behaviors induced by AD with the intestinal microbiota.Additionally,it sought to evaluate the therapeutic potent... Objective:This study aimed to investigate the association of atopic dermatitis(AD)and anxiety/depression behaviors induced by AD with the intestinal microbiota.Additionally,it sought to evaluate the therapeutic potential of mannan oligosaccharide(MOS)in alleviating AD symptoms through the modulation of the gut microbiota and the enhancement of short-chain fatty acids(SCFAs)production.Methods:Female Kunming mice were challenged with 2,4-dinitrofluorobenzene(DNFB)to induce AD-like symptoms.MOS was administered orally daily for 14 days.On the 6th and 11th days post-modeling,the number of scratching bouts in mice was recorded.Following dissection,epidermal thickness,mast cell infiltration,and serum levels of inflammatory cytokines were measured.Meanwhile,cerebral levels of neurotransmitters,including 5-hydroxytryptamine(5-HT)and norepinephrine(NE),were assessed.The abundance of intestinal microbiota and fecal concentrations of SCFAs were also analyzed.Results:MOS significantly reduced AD-like symptoms by reducing inflammatory cytokines,as reflected in a significant decrease in the number of scratching bouts,epidermal thickness,mast cells and inflammatory cytokine levels.MOS intervention up-regulated the expression of 5-HT and NE,and consequently alleviated anxiety and depression-like behaviors.Furthermore,compared with the AD group,MOS intervention increased the gut microbiota abundance of mice,especially beneficial bacteria such as Bifidobacterium,Lactobacillus and Klebsiella.At the same time,these beneficial bacteria significantly increased the fecal contents of SCFAs,especially propionic acid.Correlation analysis indicated that AD amelioration was positively correlated with fecal SCFAs levels and the proliferation of certain intestinal microbes.Conclusion:MOS intervention could offer a novel approach to managing AD and its psychological comorbidities. 展开更多
关键词 mannan oligosaccharides atopic dermatitis anxiety and depression-like behaviors gut microbiota
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Therapy and mechanism of natural polysaccharides for atopic dermatitis treatment 认领 引用
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作者 Wenjie Wang Lijun Shao +3 位作者 Xiao Jiang Qiulu Chu Jian Xiao Shufang Wu 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第5期1625-1640,共16页
Atopic dermatitis(AD)is a common multifactorial skin disease characterized by chronic inflammation,unbearable itching,and significant physical and mental burden on patients.In recent years,there has been extensively s... Atopic dermatitis(AD)is a common multifactorial skin disease characterized by chronic inflammation,unbearable itching,and significant physical and mental burden on patients.In recent years,there has been extensively studied on the use of natural polysaccharides in anti-inflammatory therapy,due to their low toxicity and multi-target pharmacological activity.The unique biological activities of polysaccharides from natural sources as functional food additives and cosmeceuticals present a new option for the treatment of AD.This review aims to summarize the pathogenesis of AD,the therapeutic effects,and the mechanisms of natural polysaccharides,as well as discuss the limitations and prospects of these compounds in the treatment of AD.The insights provided in this review can serve as references and inspiration for the development of applications of natural polysaccharides in the treatment of AD. 展开更多
关键词 Atopic dermatitis Polysaccharide Inflammation
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Continuous treatment strategies improve psychological status and quality of life in patients with atopic dermatitis 认领 引用
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作者 Yi-Bo Meng Yao-Hui Ma +3 位作者 Yun Yang Dan-Dan Li Ren-Xiang Zhang Cui-Min Ren 《World Journal of Psychiatry》 SCIE 2025年第10期129-138,共10页
BACKGROUND Atopic dermatitis is a chronic inflammatory skin disease that poses a substantial burden on patients'physical health,as well as on their psychological health and quality of life.This study specifically ... BACKGROUND Atopic dermatitis is a chronic inflammatory skin disease that poses a substantial burden on patients'physical health,as well as on their psychological health and quality of life.This study specifically examines active disease phases(excluding spontaneous remission periods)to investigate the efficacy of continuous treatments on the psychological state and life quality of patients with atopic dermatitis.AIM To evaluate the effectiveness of continuous treatment strategies,including dermatological care,psychological counseling,education,and long-term follow-up,on the psychological state and quality of life in patients with atopic dermatitis.METHODS A retrospective cohort study was conducted on 120 atopic dermatitis patients treated at our hospital between June 2023 and May 2024.A total of 120 patients were randomly assigned into control and intervention groups(60 patients each).The control group underwent routine treatment,and the intervention group was treated using continuous treatment strategies,including personalized skin care plan,psychological counseling,patient education,and long-term follow-up.Quality of life and psychological status of patients were assessed using the dermatology life quality index and Hospital Anxiety and Depression Scale.RESULTS At 12 months post-intervention,the dermatology life quality index scores in the intervention group were significantly lower than those in the control group(P<0.01),implying improved quality of life.The anxiety and depression symptoms were significantly lower in the intervention group when compared to the control group(P<0.05)as per the Hospital Anxiety and Depression Scale.In the intervention group,the rate of recurrence of skin symptoms was 15%compared to 35%in the control group,with a statistically significant difference between the two groups.CONCLUSION Continuous treatment for atopic dermatitis patients greatly improve their psychological state and quality of life,enhance disease-free survival,and offer new trains of thought for clinical treatment.Personalized integrated management over a prolonged time is important to improve quality of life in such patients. 展开更多
关键词 Atopic dermatitis Continuous treatment Quality of life Mental health Retrospective study
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Advances on the role of mycobiome in atopic dermatitis 认领 引用
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作者 Yu Yu Xiaodong She Xu Yao 《Allergy Medicine》 2025年第3期20-28,共9页
Background:Atopic dermatitis(AD)is a prevalent chronic skin disorder with a complex etiology involving ge-netic,environmental,and immunological factors.The skin mycobiome has been increasingly implicated in the pathop... Background:Atopic dermatitis(AD)is a prevalent chronic skin disorder with a complex etiology involving ge-netic,environmental,and immunological factors.The skin mycobiome has been increasingly implicated in the pathophysiology of AD.Purpose:Provides a comprehensive overview of current understanding regarding the function of the skin mycobiome in AD,along with emerging research opportunities within this domain.Recent findings:In AD,the predominant fungi are Malassezia species,primarily M.restricta and M.globosa,yet their abundance is reduced,while the abundance of non-Malassezia fungi increases,leading to enhanced fungal diversity.Mycobiome may play a role in AD by eliciting immune responses or through interactions with other microorganisms.Conclusion:This review highlights the growing importance of mycobiome in AD,particularly Malassezia offers insights into disease pathogenesis and progression. 展开更多
关键词 Atopic dermatitis Mycobiome Malassezia Mechanism
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Adverse effects of dupilumab in a child with atopic dermatitis:A case report of anaphylaxis and literature review 认领 引用
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作者 Jing Zhang Zhouxian Pan +2 位作者 Shisu Zhao Jihan li Jinlyu Sun 《Allergy Medicine》 2025年第1期41-44,共4页
Atopic dermatitis(AD)is one of the most common chronic inflammatory skin diseases.It usually develops in childhood and may persist into adulthood.Dupilumab is a fully human monoclonal antibody directed against interle... Atopic dermatitis(AD)is one of the most common chronic inflammatory skin diseases.It usually develops in childhood and may persist into adulthood.Dupilumab is a fully human monoclonal antibody directed against interleukin-4R-alpha,the common chain of interleukin-4 and interleukin-13 receptors.Dupilumab showed clinical improvements in patients with atopic dermatitis,asthma,and chronic rhinosinusitis and is currently under development for other indications.However,there are many adverse effects reported after dupilumab therapy including local injection site reactions,conjunctivitis,headache,and nasopharyngitis.We report a new case of a 4-year-old child who experienced anaphylaxis after dupilumab injection.In addition to,we summary and disscuss the rare adverse reactions caused by dupilumab injection by searching the literature in pubmed. 展开更多
关键词 Atopic dermatitis Dupilumab Interleukin Adverse effect
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Impact of socioeconomic factors on pediatric atopic dermatitis population 认领 引用
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作者 Srilakshmi Haripriya Ponukumati Rahul Mittal Barbara Ann Tafuto 《World Journal of Meta-Analysis》 2025年第2期61-70,共10页
BACKGROUND Atopic dermatitis(AD),or eczema,is a chronic,pruritic inflammatory skin disease affecting children and adults.Socioeconomic status(SES)plays a significant role in developing AD.However,mixed evidence from a... BACKGROUND Atopic dermatitis(AD),or eczema,is a chronic,pruritic inflammatory skin disease affecting children and adults.Socioeconomic status(SES)plays a significant role in developing AD.However,mixed evidence from a previous study by Bajwa et al makes it difficult to determine the directionality of the association.There is a lite-rature gap in understanding the causal association between AD and socioeco-nomic factors.AIM To evaluate the impact of disparities in SES on pediatric AD populations.METHODS Based on the eligibility criteria,the literature review identified eight articles since July 2021,and a descriptive analysis was conducted using an Excel spreadsheet on key components collected from the identified studies.RESULTS Eight observational studies assessed SES in pediatric AD.Five observational studies showed mixed associations between AD and SES.Sub-analysis revealed that urban areas had a higher prevalence of AD,and four studies identified a positive association between parental education and AD in the pediatric popu-lation.Socioeconomic variables,such as residential areas and household income,significantly influence disease outcomes.CONCLUSION There is mixed association between pediatric AD and SES,with AD positively associated with parental education.There is critical need to evaluate global impact of SES variables on pediatric AD. 展开更多
关键词 Atopic dermatitis Socioeconomic factors Eczema Neurodermatitis Disseminated neurodermatitis Infantile eczema Socioeconomic disparities
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Efficacy of Taxi San on staphylococcus aureus colonization in atopic dermatitis patients with dampness-heat syndrome 认领 引用
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作者 LIU Jingyao FENG Xia +2 位作者 BIAN Xu LI Chunmeng ZHAO Yiding 《World Journal of Integrated Traditional and Western Medicine》 2025年第1期19-27,共9页
Background:Atopic dermatitis is a chronic inflammatory skin disorder characterized by recurrent eczema-like rashes and severe itching.Taxi San is an external herbal formulation with the effects of clearing heat,drying... Background:Atopic dermatitis is a chronic inflammatory skin disorder characterized by recurrent eczema-like rashes and severe itching.Taxi San is an external herbal formulation with the effects of clearing heat,drying dampness,detoxifying,and relieving itching,making it suitable for treating acute and subacute dermatitis or eczema.Objectives:To evaluate the clinical efficacy of topical Taxi San in treating atopic dermatitis patients with dampness-heat syndrome and its inhibitory effect against Staphylococcus aureus(S.aureus)colonization.Methods:50 patients with atopic dermatitis were enrolled from the Dermatology Department of Shaanxi Provincial Hospital of Traditional Chinese Medicine,with bilateral symmetrical lesions selected as target sites.The control-side lesions were treated with boric acid solution wet compresses,while the treatment-side lesions received Taxi San solution wet compresses,both administered twice daily for 14 d.Clinical efficacy was evaluated using the Scoring Atopic Dermatitis(SCORAD),Investigator Global Assessment(IGA),Dermatology Life Quality Index/Children’s Dermatology Life Quality Index(DLQI/CDLQI),adverse events(AEs)and S.aureus colonization density,which were compared between the groups.The antibacterial efficacy of Taxi San was further investigated through in vitro antibacterial tests.Results:After 14 d of treatment with Taxi San,erythema and pimples were reduced on the treated sides.Additionally,the SCORAD,IGA,and DLQI/CDLQI scores showed significant decreases(P<0.05).S.aureus colonization on the treated sides declined markedly from 78%to 4.76%.Compared to the control sides,the reduction in S.aureus colonization following 14 d of Taxi San treatment was statistically significant(P<0.05).Furthermore,in vitro antibacterial assays demonstrated that the minimum inhibitory concentration of Taxi San against the seven tested S.aureus strains was 0.125 g/mL.Conclusions:Taxi San effectively reduces S.aureus colonization and ameliorates clinical symptoms in atopic dermatitis patients with dampness-heat syndrome,demonstrating high therapeutic potential and safety. 展开更多
关键词 Atopic dermatitis Staphylococcus aureus Taxi San
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Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice 认领 引用 被引量：7
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作者 Mijung Yeom Sora Ahn +10 位作者 Dae-Hyun Hahm Sun-Young Jang Se Hoon Jang Su-Yang Park Jae-Hwan Jang Jihan Park Ju-Young Oh In-Seon Lee Kyuseok Kim Soon-Kyeong Kwon Hi-Joon Park 《Journal of Integrative Medicine》 SCIE CAS CSCD 2024年第5期600-613,共14页
Objective Atopic dermatitis(AD)is a chronic inflammatory skin disease that may be linked to changes in the gut microbiome.Acupuncture has been proven to be effective in reducing AD symptoms without serious adverse eve... Objective Atopic dermatitis(AD)is a chronic inflammatory skin disease that may be linked to changes in the gut microbiome.Acupuncture has been proven to be effective in reducing AD symptoms without serious adverse events,but its underlying mechanism is not completely understood.The purpose of this study was to investigate whether the potential effect of acupuncture on AD is gut microbiota-dependent.Methods AD-like skin lesions were induced by applying MC903 topically to the cheek of the mouse.Acupuncture was done at the Gok-Ji(LI11)acupoints.AD-like symptoms were assessed by lesion scores,scratching behavior,and histopathological changes;intestinal barrier function was measured by fecal output,serum lipopolysaccharide levels,histopathological changes,and mRNA expression of markers involved in intestinal permeability and inflammation.Gut microbiota was profiled using 16S rRNA gene sequencing from fecal samples.Results Acupuncture effectively improved chronic itch as well as the AD-like skin lesions with epidermal thickening,and also significantly altered gut microbiota structure as revealed byβ-diversity indices and analysis of similarities.These beneficial effects were eliminated by antibiotic depletion of gut microbiota,but were reproduced in gut microbiota-depleted mice that received a fecal microbiota transplant from acupuncture-treated mice.Interestingly,AD mice had intestinal barrier dysfunction as indicated by increased intestinal permeability,atrophy of the mucosal structure(reduced villus height and crypt depth),decreased expression of tight junctions and mucus synthesis genes,and increased expression of inflammatory mediators in the ileum.Acupuncture attenuated these abnormalities,which was gut microbiota-dependent.Conclusion Acupuncture ameliorates AD-like phenotypes in a gut microbiota-dependent manner and some of these positive benefits are explained by modulation of the intestinal barrier,providing new perspective for non-pharmacological strategies for modulating gut microbiota to prevent and treat AD. 展开更多
关键词 Atopic dermatitis Acupuncture Gut microbiota Intestinal barrier function
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Successful treatment of lichen amyloidosis coexisting with atopic dermatitis by dupilumab:Four case reports 认领 引用 被引量：4
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作者 Qing Zhu Bing-Quan Gao +2 位作者 Jin-Fang Zhang Li-Ping Shi Guo-Qiang Zhang 《World Journal of Clinical Cases》 SCIE 2023年第11期2549-2558,共10页
BACKGROUND Lichen amyloidosis(LA)is a chronic,severely pruritic skin disease,which is the most common form of primary cutaneous amyloidosis.The treatment of LA has been considered to be difficult.LA may be associated ... BACKGROUND Lichen amyloidosis(LA)is a chronic,severely pruritic skin disease,which is the most common form of primary cutaneous amyloidosis.The treatment of LA has been considered to be difficult.LA may be associated with atopic dermatitis(AD),and in this setting,the treatment options may be more limited.Herein,we report four cases of LA associated with AD successfully treated by dupilumab.CASE SUMMARY In this article,we describe four cases of patients who presented with recurrent skin rash accompanied by severe generalized intractable pruritus,diagnosed with refractory LA coexisting with chronic AD.Previous treatments had not produced any apparent improvement.Thus,we administered dupilumab injection subcutaneously at a dose of 600 mg for the first time and 300 mg every 2 wk thereafter.Their lesions all markedly improved.CONCLUSION Dupilumab may be a new useful treatment for LA coexisting with AD. 展开更多
关键词 Lichen amyloidosis Atopic dermatitis Dupilumab Biologics Interleukin-31 Case report
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Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula 认领 引用 被引量：6
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作者 Jingang Liu Yan Sun +7 位作者 Huimin Yuan Yuda Li Jing Feng Yushan Gao Yang Tang Shujing Zhang Hang Wang Fengjie Zheng 《Journal of Traditional Chinese Medical Sciences》 CAS 2021年第4期309-316,共8页
Objective: To reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis(AD).Methods: Sixty specific-pathog... Objective: To reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis(AD).Methods: Sixty specific-pathogen free male BALB/c mice were randomly divided into the control group,model group, whole formula group(WF), exterior-releasing formula group(ERF), interior-clearing formula group(ICF), and positive control group(PC). A mouse model of AD was established using the semiantigen 2,4-dinitrofluorobenzene induction method. The lesion scores, transepidermal water loss and p H, and skin histopathology of mice in each group were observed. The expressions of filaggrin, loricrin,and involucrin were detected by the streptavidin peroxidase immunohistochemical method and western blotting, and their mRNA expressions were detected by quantitative polymerase chain reaction.Results: Mice in the WF, ERF, ICF, and PC groups showed reduced skin lesion performance, improved histopathology, decreased skin lesion score, transepidermal water loss and pH, and upregulated expressions of proteins including filaggrin, loricrin, and involucrin, and their mRNAs. The most obvious regulatory effect was observed in the WF group, followed by the ICF, ERF, and PC groups, accordingly.Conclusions: Mahuang Lianqiao Chixiaodou decoction and its disassembled formula can improve the skin barrier function in a mouse model of AD by upregulating filaggrin, loricrin, and involucrin, and their mRNA expressions, and the most optimal effect was noted in the WF group, followed by the ICF and ERF groups, which suggests that the effect of clearing heat and resolving dampness in improving the skin barrier function of AD is more obvious and is one of the key treatments for AD. 展开更多
关键词 Atopic dermatitis Mahuang Lianqiao Chixiaodou decoction Correspondence between pattern and formula elements Skin barrier
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