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Chaihu-Shugan-San ameliorates chronic atrophic gastritis by inhibiting nuclear factor-kappa B-mediated inflammation and apoptosis 认领 引用
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作者 Jin Song Dan-Yan Li +6 位作者 Xiao-Li Zhang Sha-Sha He Ning Wang Hui-Cun Zhang Yun-Jing Bai Bo Li Sheng-Sheng Zhang 《World Journal of Gastroenterology》 SCIE CAS 2026年第10期134-151,共18页
BACKGROUND Chaihu-Shugan-San(CSS),a classic traditional Chinese medicine formula,has demonstrated significant efficacy in treating various gastrointestinal disorders.AIM To explore the therapeutic efficacy of CSS in a... BACKGROUND Chaihu-Shugan-San(CSS),a classic traditional Chinese medicine formula,has demonstrated significant efficacy in treating various gastrointestinal disorders.AIM To explore the therapeutic efficacy of CSS in alleviating chronic atrophic gastritis(CAG),and elucidate the underlying mechanisms of action.METHODS High performance liquid chromatography-mass spectrometry was used to identify the main active components of CSS.The therapeutic effects of CSS at doses of 925 mg/kg/day and 1850 mg/kg/day on N-methyl-N’-nitro-N-nitrosoguanidine(MNNG)-induced CAG were evaluated.Network pharmacology and molecular docking were used to predict the potential targets of CSS in CAG.The impact of CSS on the gut microbiota of rats was investigated by 16S rRNA sequencing.RESULTS The main active components of CSS were lipids and lipid-like molecules,phenylpropanoids and polyketides.In vivo experiments showed that CSS significantly ameliorated MNNG-induced CAG by inhibiting inflammation and apoptosis.The core target of CSS to alleviate CAG were tumor necrosis factor,interleukin(IL)-1β,IL-6,BAX,BCL2,caspase-3/caspase-9,and NFKBIA.Gene Ontology analysis of these core targets revealed their predominant association with the nuclear factor-kappa B(NF-κB)signaling complex and BAX apoptotic complex.Molecular docking demonstrated that six compounds in CSS,including baicalin,licoisoflavone B,licochalcone B,glabrone,glycyrrhiza flavonol A,and marmin exhibited strong binding affinities with NFKBIA.16S rRNA sequencing indicated that CSS promoted beneficial changes in the colonic microbial community.CONCLUSION CSS alleviated CAG by inhibiting NF-κB-mediated inflammation and apoptosis,providing insights into its mechanism of action in protection against CAG. 展开更多
关键词 Chronic atrophic gastritis Chaihu-Shugan-San Inflammation Apoptosis Nuclear factor-kappa B
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Mechanistic insights into Banxia Xiexin Decotion-induced gastric mucosal restoration in rats with chronic atrophic gastritis and gastric precancerous lesions:the role of the Notch pathway 认领 引用
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作者 Jia-Le Ma Xin-Yuan Zhang +3 位作者 Yu-Yao Wang Meng-Tong Leng Hui-Zhen Li Tai-Yi Wang 《Traditional Medicine Research》 2026年第4期27-38,共12页
Background:The development of gastric cancer(GC)encompasses precancerous conditions like chronic atrophic gastritis(CAG)and premalignant lesions of gastric cancer(PLGC).In these situations,abnormal Notch signaling res... Background:The development of gastric cancer(GC)encompasses precancerous conditions like chronic atrophic gastritis(CAG)and premalignant lesions of gastric cancer(PLGC).In these situations,abnormal Notch signaling results in mucosal impairment and the initiation of cancer.Banxia Xiexin Decoction(BXD),a well-known formula in traditional Chinese medicine(TCM),shows promise in treating gastric disorders,but its mechanisms in gastric restoration remain unclear.Methods:Using MNNG-induced CAG and PLGC rat models,BXD was administered for 12 weeks.Gastric mucosal pathology was assessed via hematoxylin-eosin staining.Proliferation(Ki-67)and angiogenesis(VEGFA)markers were evaluated by immunohistochemistry.Network pharmacology identified BXD’s targets and pathways.Notch pathway components(Notch1,Jagged1,Dll4,Hes1)were analyzed via qPCR,Western blot,and immunohistochemistry.Results:BXD significantly ameliorated mucosal atrophy,glandular structural disorder,and dysplasia in CAG and PLGC rats.Network pharmacology revealed 323 overlapping targets between BXD and PLGC,with Notch signaling as a central pathway.BXD downregulated Notch1,Jagged1,Dll4,and Hes1 expression at transcriptional and protein levels,suppressed Ki-67(proliferation)and VEGFA(angiogenesis)overexpression,and restored gastric mucosal integrity.Conclusion:BXD inhibits Notch signaling,reduces aberrant proliferation and angiogenesis,and interrupts Correa’s gastric carcinogenesis cascade.This study provides mechanistic evidence supporting BXD as a TCM-based intervention for gastric precancerous lesions. 展开更多
关键词 Banxia Xiexin Decotion chronic atrophic gastritis gastric precancerous lesions premalignant lesions of gastric cancer Notch signaling pathway
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Anwei decoction alleviates chronic atrophic gastritis by modulating the gut microbiota-metabolite axis and NLRP3 inflammasome activity 认领 引用 被引量：1
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作者 Hong Qin Yi-Yang Liu +7 位作者 Qiang Li Sai-Yan Wei Li-Yun Huang Chai-Feng Zhou Li-Yan Tan Jing-Wen Zhang De-Kun Wu You-Ming Tang 《World Journal of Gastroenterology》 SCIE CAS 2026年第1期171-191,共21页
BACKGROUND Chronic atrophic gastritis(CAG)is a clinically refractory gastric disease often characterized by high recurrence rates and adverse drug reactions.Anwei decoction(AWD),a traditional Chinese medicine formula,... BACKGROUND Chronic atrophic gastritis(CAG)is a clinically refractory gastric disease often characterized by high recurrence rates and adverse drug reactions.Anwei decoction(AWD),a traditional Chinese medicine formula,has been shown to significantly improve clinical symptoms in patients with CAG,as demonstrated by a multicenter cohort study(overall effective rate:82.5%,P<0.01).However,the unclear molecular mechanisms and therapeutic targets of AWD limit its international acceptance.AIM To investigate the therapeutic mechanisms of AWD against CAG from an integrated perspective.METHODS In this study,N-methyl-N’-nitro-N-nitrosoguanidine was used to establish a CAG rat model.Serum-derived constituents transferred from AWD were first identified using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry.The concentrations of inflammatory cytokines in serum samples were determined by enzyme-linked immunosorbent assay.Moreover,gastric mucosal tissues were analyzed by quantitative realtime polymerase chain reaction to measure messenger RNA(mRNA)levels of the NLRP3 inflammasome.Western blotting was used to detect the protein expression of NLRP3,caspase-1,and interleukin(IL)-1β.To elucidate the regulatory mechanisms underlying AWD treatment,structural alterations of the gut microbiota(GM)and associated metabolites were analyzed using integrated high-throughput sequencing(16S rRNA)and liquid chromatography-mass spectrometry based untargeted metabolomics.This comprehensive approach systematically clarified AWD’s multi-target therapeutic mechanisms against CAG.RESULTS AWD notably reduced serum levels of pro-inflammatory cytokines,such as IL-1β,IL-18,tumor necrosis factor-α,and lipopolysaccharide,demonstrating significant statistical differences(all P<0.01).Additionally,AWD substantially inhibited NLRP3 mRNA expression in gastric mucosal tissue(P<0.01)and concurrently decreased the protein abundance of NLRP3,IL-1β,and caspase-1(all P<0.01),thereby suppressing inflammasome signaling activation.GM analysis indicated that AWD intervention significantly increased the relative abundance of beneficial bacteria.Associated microbial metabolites likely inhibited the NLRP3 inflammasome pathway by modulating immune cell function.Non-targeted metabolomics further indicated that AWD exerted anti-inflammatory effects by regulating critical metabolic pathways,including the Kaposi’s sarcoma-associated herpesvirus infection pathway,autophagy processes,and glycosylphosphatidylinositol-anchor biosynthesis.CONCLUSION AWD alleviates the pathological progression of CAG through multi-target synergistic mechanisms.On one hand,AWD directly suppresses gastric mucosal inflammation by inhibiting NLRP3 inflammasome activation.On the other hand,AWD remodels intestinal microbiota-metabolite homeostasis,enhances intestinal barrier function,and regulates mucosal immune responses. 展开更多
关键词 Anwei decoction Chronic atrophic gastritis Gut microbiota-metabolite axis NLRP3 inflammasome Traditional Chinese medicine
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From traditional formula to modern mechanism:How Anwei decoction alleviates chronic atrophic gastritis via regulating the gutstomach axis 认领 引用
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作者 Wen-Xin Dai Hao-Wei Li +2 位作者 Wei Guo Li-Yun Zheng Huo-Xiang Zhou 《World Journal of Gastroenterology》 SCIE CAS 2026年第19期1-5,共5页
Chronic atrophic gastritis(CAG)represents a significant precancerous gastric condition with limited effective treatments that can reverse pathological progression.Traditional Chinese medicine presents a multi-targeted... Chronic atrophic gastritis(CAG)represents a significant precancerous gastric condition with limited effective treatments that can reverse pathological progression.Traditional Chinese medicine presents a multi-targeted therapeutic approach for CAG.Recently,Qin et al published a study in World Journal of Gastroenterology,which presented the therapeutic potential of Anwei decoction(AWD)in a rat model of CAG.They demonstrated that AWD alleviated gastric mucosal injury through dual mechanisms.First it directly suppressed the NLR family pyrin domain containing 3 inflammasome.Second,it reshaped gut microbiota and its metabolites,thereby exerting distal regulation via the“gut-stomach axis”.This study not only elucidated the multi-component,multi-target action characteristics of AWD,but also paved new pathways for developing treatment strategies for complex gastrointestinal diseases based on the“microbiome-metabolism-immunity”network.This commentary briefly outlined the clinical significance and current therapeutic limitations of CAG as a precancerous lesion,emphasized the integration of traditional Chinese medicine with multi-omics technologies and presented future research directions,involving clinical translation and identification of active components. 展开更多
关键词 Traditional Chinese medicine Anwei decoction Chronic atrophic gastritis Gut microbiota NLR family pyrin domain containing 3 inflammasome
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Risk prediction for chronic atrophic gastritis using a random forest model:A multicenter study 认领 引用
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作者 Hui Cao Jing-Lue Han +12 位作者 Shu-Ping Si Li-Jia Ding Lin Ji Hua-Zhen Zhang Jie Yin Yu-Nan Zhang Zhi-Fa Lv Wen-Ying Tian Qiang Zhan Hui Wang Fang-Mei An Hao Wu Zhi-Yi Zhou 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第2期97-111,共15页
BACKGROUND Chronic atrophic gastritis(CAG)is a significant precancerous condition of gastric cancer(GC).CAG often lacks typical symptoms in its early stages,and clinical diagnosis relies on gastroscopy and pathologica... BACKGROUND Chronic atrophic gastritis(CAG)is a significant precancerous condition of gastric cancer(GC).CAG often lacks typical symptoms in its early stages,and clinical diagnosis relies on gastroscopy and pathological examination,which are invasive and have limitations such as poor patient compliance.Therefore,developing a noninvasive,simple,and generalizable prediction tool is crucial for the early identification of CAG.AIM To construct and validate a CAG risk prediction model to achieve noninvasive and accurate identification of high-risk patients.METHODS This study included 1268 subjects from a GC screening program.Multimodal data,including serological marker,demographic,lifestyle,and family history data,were collected.Subjects were grouped by pathological biopsy results.Least absolute shrinkage and selection operator regression was used for feature selection.A model was constructed using the random forest algorithm,evaluated with metrics such as the area under the curve(AUC),and interpreted using the SHapley Additive exPlanation(SHAP)method.The model was validated in an independent external cohort,and a web-based prediction platform was developed using Shiny.RESULTS Six key features were ultimately included:Age,Helicobacter pylori(H.pylori)infection status,pepsinogenⅠ/Ⅱratio(PGR),smoking history,alcohol consumption history,and family history of GC.The model achieved AUCs of 0.8542 and 0.8073 in the training and testing sets,respectively,and an AUC of 0.8505 in the external validation cohort,demonstrating good generalizability and stability.SHAP analysis indicated that H.pylori infection,age,and PGR were the most important variables influencing CAG risk.The final model was successfully embedded into a web-based platform for convenient clinical application.CONCLUSION The random forest-based CAG prediction model is a highly accurate and interpretable tool with significant clinical utility in early screening and identifying high-risk patients. 展开更多
关键词 Chronic atrophic gastritis Machine learning Risk prediction Gastric cancer screening Random forest
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Academic Thought and Clinical Practice of Pattern Differentiation and Treatment for Chronic Atrophic Gastritis Based on Theory of Qi Deficiency with Stagnation and Principle of Achieving Central Harmony 认领 引用
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作者 Jingxian LI Peifang LI 《Medicinal Plant》 2026年第1期65-71,共7页
This study makes an in-depth exploration of the core pathogenesis of chronic atrophic gastritis,Qi Deficiency with Stagnation,to systematically interpret it within the theoretical framework of Achieving Central Harmon... This study makes an in-depth exploration of the core pathogenesis of chronic atrophic gastritis,Qi Deficiency with Stagnation,to systematically interpret it within the theoretical framework of Achieving Central Harmony,and to provide a treatment plan.Professor Li Tingquan believes that the occurrence and development of chronic atrophic gastritis(CAG)is fundamentally a process of harmony imbalance of the spleen and stomach.Its specific manifestation lies in the interaction between qi deficiency and stagnation,namely,spleen deficiency as the root cause,and qi stagnation,phlegm-dampness,and blood stasis obstructing the middle energizer as the secondary manifestations.These factors are mutually causal and interact with one another.Based on this,he proposed a four-step method to treat the disease:eliminating pathogenic factors,harmonizing the spleen and stomach,activating blood circulation to resolve stasis,and tonifying the kidney to generate blood(metaphorically described as"closing the mountains to cultivate forests and thicken the soil,breeding seeds and irrigating for stomach recovery").This approach aims to restore the harmonious state of the middle energizer,providing a complete clinical framework of theory,principle,formula,and herbs for the prevention and treatment of CAG. 展开更多
关键词 Achieving Central Harmony Qi Deficiency with Stagnation Chronic atrophic gastritis(CAG) Academic thought Clinical experience
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Traditional Chinese medicine for chronic atrophic gastritis:Efficacy,mechanisms and targets 认领 引用 被引量：25
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作者 Li Wang Yan-Jie Lian +6 位作者 Jin-Sheng Dong Ming-Kun Liu Hong-Liang Liu Zheng-Min Cao Qing-Nan Wang Wen-Liang Lyu Yu-Ning Bai 《World Journal of Gastroenterology》 SCIE CAS 2025年第9期9-29,共21页
Chronic atrophic gastritis(CAG)is an important stage of precancerous lesions of gastric cancer.Effective treatment and regulation of CAG are essential to prevent its progression to malignancy.Traditional Chinese medic... Chronic atrophic gastritis(CAG)is an important stage of precancerous lesions of gastric cancer.Effective treatment and regulation of CAG are essential to prevent its progression to malignancy.Traditional Chinese medicine(TCM)has shown multi-targeted efficacy in CAG treatment,with advantages in enhancing gastric mucosal barrier defense,improving microcirculation,modulating inflammatory and immune responses,and promoting lesion healing,etc.Clinical studies and meta-analyses indicate that TCM provides significant benefits,with specific Chinese herbal compounds and monomers demonstrating protective effects on the gastric mucosa through mechanisms including anti-inflammation,antioxidation,and regulation of cellular proliferation and apoptosis,etc.Finally,it is pointed out that the efficacy of TCM in the treatment of CAG requires standardized research and unified standards,and constantly clarifies and improves the evaluation criteria of each dimension of gastric mucosal barrier function. 展开更多
关键词 Traditional Chinese medicine Gastric mucosal barrier Chronic atrophic gastritis Therapeutic efficacy Treating target
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Potential of traditional Chinese medicine in gastrointestinal disorders:Hericium erinaceus in chronic atrophic gastritis 认领 引用 被引量：1
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作者 Raffaele Pellegrino Antonietta Gerarda Gravina 《World Journal of Gastroenterology》 SCIE CAS 2025年第20期122-126,共5页
Traditional Chinese medicine(TCM)has been extensively explored with various naturally derived compounds as a potential therapeutic agent for chronic atrophic gastritis(CAG).In addition to the aspects discussed in the ... Traditional Chinese medicine(TCM)has been extensively explored with various naturally derived compounds as a potential therapeutic agent for chronic atrophic gastritis(CAG).In addition to the aspects discussed in the reviewed article,this invited commentary explores the initial available evidence on a fungus from TCM,Hericium erinaceus,in the context of CAG.Initial clinical data suggest the potential of this fungus in inducing clinical and histological improvements in patients with CAG,as well as a marked antimicrobial activity against Helicobacter pylori infection.Preclinical cellular evidence also indicates an antineoplastic role in gastric carcinogenesis,mediated by two components:Erinacine A and S.Further evidence is needed to propose this fungus as a potential complementary thera-peutic approach for CAG. 展开更多
关键词 Traditional Chinese medicine Chronic atrophic gastritis Hericium erinaceus Gastrointestinal disorders Helicobacter pylori
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Exploration of the mechanism of the Mongolian medicine Tonglaga-5(通拉嘎-5)for the treatment of n-methyl-n′-nitro-n-nitrosoguanidine-induced chronic atrophic gastritis based on network pharmacology and metabolomics 认领 引用 被引量：1
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作者 CHENG Ziqi DONG Xin +8 位作者 Temuribagen XU Caimeng HU Shaonan CHEN Qianwen WANG Yuewu WANG Haibo HE Xiaoyu XUE Dan XUE Peifeng 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2025年第6期1366-1375,共10页
OBJECTIVE:To explore the mechanism of Tonglaga-5(通拉嘎-5,TLG-5)for the treatment of chronic atrophic gastritis(CAG),based on network pharmacology and metabolomics.METHODS:Forty-eight male Sprague-Dawley rats were ran... OBJECTIVE:To explore the mechanism of Tonglaga-5(通拉嘎-5,TLG-5)for the treatment of chronic atrophic gastritis(CAG),based on network pharmacology and metabolomics.METHODS:Forty-eight male Sprague-Dawley rats were randomly divided into six groups(n=8):control group;model group;teprenone group,and low-,median-,and high-dose TLG-5 groups.The enzyme linked immunosorbent assay(ELISA)was used to measure the expression of pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ)and gastrin-17(G-17)in the serum.Hematoxylin and eosin staining were performed to observe the pathological condition.And the network pharmacology was employed to identify the targets and signaling pathways of TLG-5 affecting CAG.Then,the metabolomics approach was applied to explore the specific metabolites and metabolic pathways.Finally,validation was performed using the“metabolite-gene”interaction network,molecular docking and quantitative real-time polymerase chain reaction(q PCR).RESULTS:High-dose TLG-5 significantly improved the expression of PGⅠ,PGR(PGⅠ/PGⅡ)and G-17(P<0.05)and inhibited the expression of phosphoinositide-3-kinase regulatory subunit 2,AKT serinehreonine kinase(AKT),hypoxia-inducible factor 1-alpha(HIF-1α)(P<0.05).Further,high-dose TLG-5 reduced the number of glands was reduced,and fibrosis with oedema and ecchymosis appeared at the base.Overlapping TLG-5 and CAG gene targets produced 270 interactive targets.The results of gene ontology and Kyoto encyclopedia of genes and genomes enrichment analyses suggested that TLG-5 could affect CAG through the predominantly cancer and inflammation-related pathways.Pyrimidine metabolism was identified as a significantly differential pathway in the mechanism of TLG-5 for treating CAG.CONCLUSIONS:TLG-5 exerts a therapeutic effect on CAG by regulatingβ-alanine metabolism,pyrimidine metabolism pathways,and inhibiting the PI3K-AKT signaling pathway and HIF-1 signaling pathways. 展开更多
关键词 gastritis,atrophic metabolomics network pharmacology real-time polymerase chain reaction Tonglaga-5
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Gastric organoids:A promising model for studying“inflammationcancer”transition in atrophic gastritis 认领 引用 被引量：1
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作者 Chang Liu Chen-Heng Wu +3 位作者 Yue-Bo Jia Jun-Xin Qiu Xin-Yuan Li Jiang-Hong Ling 《World Journal of Clinical Oncology》 2025年第11期43-57,共15页
Current experimental models struggle to simulate the complex process of the transformation from atrophic gastritis to gastric cancer,while gastric organoid technology,especially region-specific modeling,provides a mor... Current experimental models struggle to simulate the complex process of the transformation from atrophic gastritis to gastric cancer,while gastric organoid technology,especially region-specific modeling,provides a more precise in vitro platform for studying this carcinogenic mechanism.Helicobacter pylori activates carcinogenic signaling pathways through virulence factors,inducing DNA damage,epigenetic dysregulation,and immune microenvironment imbalance,driving inflammation-cancer conversion.Intestinal metaplasia and spasmolytic polypeptide-expressing metaplasia serve as critical precursor lesions,gradually developing into dysplasia and adenocarcinoma under the influence of chronic inflammation and genetic instability through intestinal cell transformation and high trefoil factor 2-expressing cell expansion.The immune suppression,metabolic reprogramming,and matrix remodeling within the tumor microenvironment collaboratively create a pro-cancer ecosystem that accelerates inflammationcarcinogenesis transformation.The gastric organoid model successfully simulates the spatiotemporal dynamics of the carcinogenesis process in atrophic gastritis,and its future integration with single-cell omics,real-time imaging technologies,and artificial intelligence technologies could provide a more precise platform for elucidating molecular mechanisms and screening intervention strategies.These advances position gastric organoids as pivotal tools for clinical translation,enabling personalized risk stratification,early intervention targeting precancerous transitions,and ex vivo prediction of patient-specific therapeutic responses to guide precision management of gastric cancer. 展开更多
关键词 Gastric organoids Atrophic gastritis Inflammation-cancer transition Gastric cancer Helicobacter pylori Tumor microenvironment Spasmolytic polypeptide-expressing metaplasia
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Clinical Observation of Huangqi Sijun Decoction in the Treatment of Chronic Atrophic Gastritis 认领 引用 被引量：1
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作者 Yamei Wang 《Journal of Clinical and Nursing Research》 2025年第1期52-57,共6页
Objective:To evaluate the therapeutic effects of Huangqi Sijun Decoction on chronic atrophic gastritis(CAG).Methods:Sixty CAG patients hospitalized between January 2020 and December 2022 were selected and randomly div... Objective:To evaluate the therapeutic effects of Huangqi Sijun Decoction on chronic atrophic gastritis(CAG).Methods:Sixty CAG patients hospitalized between January 2020 and December 2022 were selected and randomly divided into two groups using a random number table.The Traditional Chinese Medicine(TCM)group(n=30)was treated with Huangqi Sijun Decoction,while the Western medicine group(n=30)received omeprazole.The total effective rate,TCM syndrome scores,and serological indicators were compared.Results:The total effective rate in the TCM group was higher than that in the Western medicine group,while the adverse reaction rate was lower(P0.05).After treatment,the TCM group had lower TCM syndrome scores and better serological indicators compared to the Western medicine group(P<0.05).Conclusion:Huangqi Sijun Decoction can enhance the clinical efficacy of CAG patients,prevent adverse reactions,alleviate TCM symptoms,and regulate specific levels of serological indicators,demonstrating significant therapeutic advantages. 展开更多
关键词 Huangqi Sijun Decoction Chronic atrophic gastritis TCM syndrome scores Serological indicators
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Research Progress on the Mechanism of Traditional Chinese Medicine in Treating Chronic Atrophic Gastritis 认领 引用 被引量：1
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作者 Jianxin Shen Ruxia Xue +3 位作者 Dongshan Yin Xiang Su Xiaofa Liu Jinfeng Sun 《Chinese Medicine and Natural Products》 CAS 2025年第3期140-144,共5页
Chronic atrophic gastritis(CAG)is a common type of chronic gastric disease characterized by high incidence and a certain tendency toward cancerization.In recent years,with the deepening of related research,it has been... Chronic atrophic gastritis(CAG)is a common type of chronic gastric disease characterized by high incidence and a certain tendency toward cancerization.In recent years,with the deepening of related research,it has been found that traditional Chinese medicine(TCM)exerts therapeutic effects on CAG through various signaling pathways.This article systematically reviews and summarizes the literature on TCM treatment of CAG,elaborating on the etiology and pathogenesis of CAG,new ideas from different physicians in treating CAG,and the effects of different TCM monomers and compound prescriptions on signaling pathways such as PI3K-AKT and JAK1/STAT3 to provide a reference for subsequent research on CAG. 展开更多
关键词 chronic atrophic gastritis traditional Chinese medicine signaling pathways
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Atrophic Gastritis:A Critical Precancerous Lesion 认领 引用
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作者 XING Lina ZHANG Xiyang +1 位作者 MUGE Cheli CAO Ruizhen 《Management Studies》 2025年第1期24-30,共7页
AG(atrophic gastritis)is characterized by precancerous lesions associated with gastric cancer and can cause serious adverse health effects.The high incidence coupled with a low diagnosis rate and the mediocre effectiv... AG(atrophic gastritis)is characterized by precancerous lesions associated with gastric cancer and can cause serious adverse health effects.The high incidence coupled with a low diagnosis rate and the mediocre effectiveness of clinical treatment raises concerns.This article reviews the pathologic features,clinical manifestations,and treatment progress of AG. 展开更多
关键词 atrophic gastritis pathologic features treatment progress
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Clinical experience of national TCM master LIAN Jianwei in treating chronic atrophic gastritis based on syndrome differentiation and pulse diagnosis 认领 引用
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作者 YANG Weijia LIAN Jianwei 《World Journal of Integrated Traditional and Western Medicine》 2025年第1期34-41,共8页
This study summarizes the clinical experience of professor LIAN Jianwei, a nationally renowned traditional Chinese medicine (TCM) practitioner, in treating chronic atrophic gastritis (CAG) with syndrome differentiatio... This study summarizes the clinical experience of professor LIAN Jianwei, a nationally renowned traditional Chinese medicine (TCM) practitioner, in treating chronic atrophic gastritis (CAG) with syndrome differentiation based on pulse-taking. Professor LIAN emphasizes the importance of pulse diagnosis in TCM clinical practice, focusing on the normal and variant aspects of pulse methods, and centers on the dynamic changes of the “Guan pulse” to accurately determine the functional status of the spleen and stomach based on pulse variations, thereby formulating personalized treatment plans. For patients with a slow and moderate pulse, spleen and stomach deficiency and dampness due to spleen deficiency are often identified, and treatment mainly focuses on strengthening the spleen, resolving dampness, and boosting Qi to aid transportation, usually with modifications of Shenling Baizhu San. When the left Guan pulse is string-like and the right Guan pulse is slow and moderate, it indicates liver depression and spleen deficiency, and Xiaoyao San is commonly used to soothe the liver, nourish the blood, and strengthen the spleen, harmonizing the liver and spleen. If the right Guan pulse is large and the left Guan pulse is string-like, it mostly belongs to liver and stomach Qi stagnation, and Bupleurum Liver-soothing powder is often used to soothe the liver, regulate Qi, and harmonize the stomach. A large and empty right Guan pulse suggests insufficiency of Central Qi, and Buzhong Yiqi Tang is commonly used to tonify Qi and soothe the liver. In terms of medication, professor LIAN pays attention to patients’ dietary habits and combines methods of eliminating dampness, promoting digestion, and activating blood circulation to improve symptoms and reverse atrophy. 展开更多
关键词 Nationally renowned traditional chinese medicine practitioner LIAN Jianwei Syndrome differentiation based on pulse-taking Chronic atrophic gastritis
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Treatment of Helicobacter pylori infection in atrophic gastritis 认领 引用 被引量：87
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作者 Edith Lahner Marilia Carabotti Bruno Annibale 《World Journal of Gastroenterology》 SCIE CAS 2018年第22期2373-2380,共8页
Helicobacter pylori(Hp) is a major human pathogen causing chronic, progressive gastric mucosal damage and is linked to gastric atrophy and cancer. Hp-positive individuals constitute the major reservoir for transmissio... Helicobacter pylori(Hp) is a major human pathogen causing chronic, progressive gastric mucosal damage and is linked to gastric atrophy and cancer. Hp-positive individuals constitute the major reservoir for transmission of infection. There is no ideal treatment for Hp. Hp infection is not cured by a single antibiotic, and sometimes, a combined treatment with three or more antibiotics is ineffective. Atrophic gastritis(AG) is a chronic disease whose main features are atrophy and/or intestinal metaplasia of the gastric glands, which arise from long-standing Hp infection. AG is reportedly linked to an increased risk for gastric cancer, particularly when extensive intestinal metaplasia is present. Active or past Hp infection may be detected by conventional methods in about two-thirds of AG patients. By immunoblotting of sera against Hp whole-cell protein lysates, a previous exposure to Hp infection is detected in all AG patients. According to guidelines, AG patients with Hp positivity should receive eradication treatment. The goals of treatment are as follows:(1) Cure of infection, resolution of inflammation and normalization of gastric functions;(2) possible reversal of atrophic and metaplastic changes of the gastric mucosa; and(3) prevention of gastric cancer. An ideal antibiotic regimen for Hp should achieve eradication rates of approximately 90%, and complex multidrug regimens are required to reach this goal. Amongst the factors associated with treatment failure are high bacterial load, high gastric acidity, Hp strain, smoking, low compliance, overweight, and increasing antibiotic resistance. AG, when involving the corporal mucosa, is linked to reduced gastric acid secretion. At a non-acidic intra-gastric p H, the efficacy of the common treatment regimens combining proton pump inhibitors with one or more antibiotics may not be the same as that observed in patients with Hp gastritis in an acid-producing stomach. Although the efficacy of these therapeutic regimens has been thoroughly tested in subjects with Hp infection, there is a paucity of evidence in the subgroupof patients with AG. Bismuth-based therapy may be an attractive treatment in the specific setting of AG, and specific studies on the efficacy of bismuth-based therapies are needed in patients with AG. 展开更多
关键词 Atrophic gastritis Preneoplastic condition Intestinal metaplasia Helicobacter pylori Eradication treatment
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Risk for gastric neoplasias in patients with chronic atrophic gastritis:A critical reappraisal 认领 引用 被引量：82
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作者 Lucy Vannella Edith Lahner Bruno Annibale 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第12期1279-1285,共7页
Chronic atrophic gastritis （CAG） is an inflammatory condition characterized by the loss of gastric glandular structures which are replaced by connective tissue （non-metaplastic atrophy） or by glandular structures ... Chronic atrophic gastritis （CAG） is an inflammatory condition characterized by the loss of gastric glandular structures which are replaced by connective tissue （non-metaplastic atrophy） or by glandular structures inappropriate for location （metaplastic atrophy）. Epidemiological data suggest that CAG is associated with two different types of tumors： Intestinal-type gastric cancer （GC） and type I gastric carcinoid （T I GC）. The pathophysiological mechanisms which lead to the development of these gastric tumors are different, It is accepted that a multistep process initiating from Helico- bacterpylori-related chronic inflammation of the gastric mucosa progresses to CAG, intestinal metaplasia, dysplasia and, finally, leads to the development of GC. The T I GC is a gastrin-dependent tumor and the chronic elevation of gastrin, which is associated with CAG, stimulates the growth of enterochromaffin-like cells with their hyperplasia leading to the development of T I GC. Thus, several events occur in the gastric mucosa before the development of intestinatype GC and/ or T I GC and these take several years. Knowledge ofCAG incidence from superficial gastritis, its prevalence in different clinical settings and possible risk factors as- sociated with the progression of this condition to gastric neoplasias are important issues. This editorial intends to provide a brief review of the main studies regarding incidence and prevalence of CAG and risk factors for the development of gastric neoplasias. 展开更多
关键词 Chronic atrophic gastritis Gastric neoplasia Intestinal-type gastric cancer Type I gastric carcinoid Prevalence Incidence Risk factors
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Efficacy of Banxia Xiexin decoction in a rat model of chronic atrophic gastritis 认领 引用 被引量：23
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作者 Bai Yu Chen Yongcan +5 位作者 Chen Yu Yan Maoxiang Wei Hongquan Wang Hengcang Zeng Guoliang Yang Xiyin 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2019年第6期867-874,共8页
OBJECTIVE:To investigate the effectiveness of Banxia Xiexin decoction(BXD)in a rat model of chronic atrophic gastritis(CAG).METHODS:Sixty 6-week-old healthy Wistar rats(30 males,30 females)were used in the present stu... OBJECTIVE:To investigate the effectiveness of Banxia Xiexin decoction(BXD)in a rat model of chronic atrophic gastritis(CAG).METHODS:Sixty 6-week-old healthy Wistar rats(30 males,30 females)were used in the present study.A rat model of CAG was successfully established using the combined active immunization/ethanol/sodium deoxycholate method.BXD was prepared from a mixture of seven Chinese herbs,and was intragastrically administered to CAG rats at three different doses(6,12,and 24 g·kg^-1·d^-1).Af-ter 24 weeks,the rats were euthanized,and gastric tissue specimens were collected.Gastric mucosal specimens were stained with hematoxylin and eosin for histological examination to evaluate the degree of inflammation and morphological changes.Immunohistochemical staining was performed to examine the mucosal expression of proliferating cell nuclear antigen.Serum gastrin levels were measured using radioimmunoassay.The expression of Notch signaling-associated genes was examined by quantitative polymerase chain reaction and Western blot assay.RESULTS:BXD at all three doses significantly reversed the adverse effects generated by CAG in rats.Compared with control rats,the CAG rats who were administered BXD had an accelerated growth rate,reduced inflammatory cell infiltration,improved gastric mucosal morphology,augmented thickness of the gastric mucosa,increased number of gastric glands,enhanced mucosal expression of proliferating cell nuclear antigen,and elevated serum gastrin levels. 展开更多
关键词 Gastritis,atrophic Receptors,Notch Gastrins Inflammation Banxia Xiexin decoction
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Effects of moxibustion and acupuncture at Zusanli(ST 36) and Zhongwan(CV 12) on chronic atrophic gastritis in rats 认领 引用 被引量：15
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作者 Liu Mi Shen Jiacheng +9 位作者 Liu Caichun Zhong Huan Yang Qing Shu Wenna Ma Mingzhu Dong Jiyang Yang Zongbao Chang Xiaorong She Chang Yu Shu 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2020年第5期827-835,共9页
OBJECTIVE:To evaluate the effects of moxibustion and acupuncture of Zusanli(ST 36)and Zhongwan(CV 12)acupoints on chronic atrophic gastritis(CAG)in rats,and to study the mechanisms behind their actions.METHODS:Forty-f... OBJECTIVE:To evaluate the effects of moxibustion and acupuncture of Zusanli(ST 36)and Zhongwan(CV 12)acupoints on chronic atrophic gastritis(CAG)in rats,and to study the mechanisms behind their actions.METHODS:Forty-four male Sprague-Dawley rats were induced with CAG by intragastric administration of 40%ethanol combined with free drinking of N-methyl-N′-nitro-N-nitrosoguanidine and irregular feeding for 12 weeks,followed by daily treatment with moxibustion or acupuncture for 2 weeks.Histopathologic examination,Western blotting of cytokines[epidermal growth factor(EGF),EGF receptor(EGFR),extracellular signal-regulated kinase(ERK),phosphorylated ERK(p-ERK)],and1 H NMR-based metabolic profiling of gastric tissues were used to measure changes related to CAG modeling and treatment.RESULTS:Moxibustion and acupuncture at Zusanli(ST 36)and Zhongwan(CV 12)each relieved CAG-induced abnormalities in histopathology and cytokine expression of ERK and p-ERK.Only moxibustion treatment regulated the expression of EGF and EGFR.Metabolites that were increased in gastric tissue by CAG induction(alanine,nicotinamide adenine dinucleotide phosphate,uracil DNA glycosylase,lactate,glycerol and adenosine)were restored to normal levels after moxibustion treatment;acupuncture treatment only normalized the levels of adenosine monophosphate and glycerol.CONCLUSION:Our findings suggest that moxibustion or acupuncture at Zusanli(ST 36)and Zhongwan(CV 12)can significantly improve the condition of CAG in rats.These treatments exert their effects on CAG through different mechanisms. 展开更多
关键词 Gastritis,atrophic Moxibustion Acupuncture Metabolomics Proton magnetic resonance spectroscopy
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Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review 认领 引用 被引量：26
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作者 Federica Cavalcoli Alessandra Zilli +1 位作者 Dario Conte Sara Massironi 《World Journal of Gastroenterology》 SCIE CAS 2017年第4期563-572,共10页
Chronic atrophic autoimmune gastritis (CAAG) is an organ-specific autoimmune disease characterized by an immune response, which is directed towards the parietal cells and intrinsic factor of the gastric body and fundu... Chronic atrophic autoimmune gastritis (CAAG) is an organ-specific autoimmune disease characterized by an immune response, which is directed towards the parietal cells and intrinsic factor of the gastric body and fundus and leads to hypochlorhydria, hypergastrinemia and inadequate production of the intrinsic factor. As a result, the stomach&#x02019;s secretion of essential substances, such as hydrochloric acid and intrinsic factor, is reduced, leading to digestive impairments. The most common is vitamin B12 deficiency, which results in a megaloblastic anemia and iron malabsorption, leading to iron deficiency anemia. However, in the last years the deficiency of several other vitamins and micronutrients, such as vitamin C, vitamin D, folic acid and calcium, has been increasingly described in patients with CAAG. In addition the occurrence of multiple vitamin deficiencies may lead to severe hematological, neurological and skeletal manifestations in CAAG patients and highlights the importance of an integrated evaluation of these patients. Nevertheless, the nutritional deficiencies in CAAG are largely understudied. We have investigated the frequency and associated features of nutritional deficiencies in CAAG in order to focus on any deficit that may be clinically significant, but relatively easy to correct. This descriptive review updates and summarizes the literature on different nutrient deficiencies in CAAG in order to optimize the treatment and the follow-up of patients affected with CAAG. 展开更多
关键词 Chronic atrophic autoimmune gastritis Nutritional deficiency Vitamin B12 Iron Vitamin C Vitamin D Calcium Malabsorption
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Histopathological classification and follow-up analysis of chronic atrophic gastritis 认领 引用 被引量：25
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作者 Yang-Kun Wang Lan Shen +3 位作者 Tian Yun Bin-Feng Yang Chao-Ya Zhu Su-Nan Wang 《World Journal of Clinical Cases》 SCIE 2021年第16期3838-3847,共10页
BACKGROUND The pathological diagnosis and follow-up analysis of gastric mucosal biopsy have been paid much attention,and some scholars have proposed the pathological diagnosis of 12 kinds of lesions and accompanying p... BACKGROUND The pathological diagnosis and follow-up analysis of gastric mucosal biopsy have been paid much attention,and some scholars have proposed the pathological diagnosis of 12 kinds of lesions and accompanying pathological diagnosis,which is of great significance for the treatment of precision gastric diseases,the improvement of the early diagnosis rate of gastric cancer,and the reduction of missed diagnosis rate and misdiagnosis rate.AIM To perform a histopathological classification and follow-up analysis of chronic atrophic gastritis(CAG).METHODS A total of 2248 CAG tissue samples were collected,and data of their clinical characteristics were also gathered.Based on these samples,the expression levels of Mucin 1(MUC1),MUC2,MUC5AC,and MUC6 in CAG tissue were tested by immunohistochemical assay.Moreover,we followed these patients for up to four years.The difference between different stages of gastroscopic biopsy was observed.RESULTS Through observation,it is believed that CAG should be divided into four types,simple type,hyperplasia type,intestinal metaplasia(IM)type,and intraepithelial neoplasia(IEN)type.Simple CAG accounted for 9.1%(205/2248),which was more common in elderly people over 60 years old.The main change was that the lamina propria glands were reduced in size and number.Hyperplastic CAG accounted for 29.1%(654/2248),mostly occurring between 40 and 60 years old.The main change was that the lamina propria glands were atrophy accompanied by glandular hyperplasia and slight expansion of the glands.IM CAG accounted for 50.4%(1132/2248),most of which increased with age,and were more common in those over 50 years.The atrophy of the lamina propria glands was accompanied by significant IM,and the mucus containing sialic acid or sulfate was distinguished according to the nature of the mucus.The IEN type CAG accounted for 11.4%(257/2248),which developed from the previous types,with severe gland atrophy and reduced mucus secretion,and is an important precancerous lesion.CONCLUSION The histological typing of CAG is convenient to understand the property of lesion,determine the follow-up time,and guide the clinical treatment. 展开更多
关键词 Gastric mucosal biopsy Chronic atrophic gastritis Histological typing Immunohistochemistry Follow-up review
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