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Deep-learning-based object detection of pelvic autonomic nerves during total mesorectal excision 认领 引用
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作者 Qiao Zhang Jin Li +3 位作者 Tao Meng Zhi-Fen Chen Xue-Zhi Zhou Xing-Rong Lu 《World Journal of Gastroenterology》 SCIE CAS 2026年第30期91-103,共13页
BACKGROUND Recognition of pelvic autonomic nerves(PAN)during total mesorectal excision(TME)largely depends on the surgeon’s expertise,making it susceptible to misrecognition and unintentional damage.There is an urgen... BACKGROUND Recognition of pelvic autonomic nerves(PAN)during total mesorectal excision(TME)largely depends on the surgeon’s expertise,making it susceptible to misrecognition and unintentional damage.There is an urgent need for objective and real-time support methods.AIM To develop a deep learning(DL)model for precise recognition and visual annotation of 5 categories of PAN during TME.METHODS This single-center retrospective study enrolled 120 TME videos from January 2021 to January 2023.A total of 3246 high-quality images were obtained and split 9:1 into training and internal test sets.Difficult-to-recognize characteristics were summarized.An additional 20 independent TME videos from June 2023 to January 2024 were used for external validation.The DL model performance was compared with that of surgeons and verified pathologically.χ2,Fisher’s exact test and t-tests were applied(P<0.05).RESULTS The DL model achieved a precision of 0.839,a recall of 0.769,and a mean average precision at intersection over union 50 of 0.873.The overall recognition rate in external validation was 76.0%,similar to senior surgeons(73.9%,P=0.156)but superior to junior surgeons(64.9%,P=0.001).The miss rate of 5 PAN categories ranged from 12.9%to 29.6%.Initial recognition time(2.08-2.21 seconds)was shorter than that of senior surgeons(5.65-6.19 seconds,P<0.01);mean continuous tracking duration was prolonged by 57.21-66.45 seconds compared with that of senior surgeons(P<0.01).Low nerve exposure caused most DL model false negatives,while cord-like fibrous tissue dominated false positives.All 7 harvested specimens were pathologically confirmed to contain nerve tissue,with a processing speed of 25 frames per second.CONCLUSION The model demonstrates recognition performance comparable to that of senior surgeons,with pathological confirmation.It may potentially help preserve PAN during TME and shorten the learning curve for junior surgeons. 展开更多
关键词 Rectal cancer Total mesorectal excision Pelvic autonomic nerve Deep learning Object detection
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Association of serum bile acid profiles with the risk of gastrointestinal autonomic neuropathy in patients with type 2 diabetes mellitus 认领 引用
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作者 Ke-Ying Zhu Si-Jing Wang +6 位作者 Jie Li Pan-Pan Ma Su-Su Feng Lin Guo Yi-Bing Lu Li Dong Da-Fa Ding 《World Journal of Diabetes》 SCIE 2026年第2期88-103,共16页
BACKGROUND Diabetic gastrointestinal autonomic neuropathy(DGAN)is a common yet underrecognized manifestation of diabetic neuropathy.However,the clinical correlations and associated alterations of serum bile acid(BA)me... BACKGROUND Diabetic gastrointestinal autonomic neuropathy(DGAN)is a common yet underrecognized manifestation of diabetic neuropathy.However,the clinical correlations and associated alterations of serum bile acid(BA)metabolism with DGAN remain unclear.AIM To identify potential metabolite biomarkers capable of identifying DGAN among patients with type 2 diabetes mellitus(T2DM).METHODS This cross-sectional study included 26 patients with clinically defined DGAN and 69 patients with uncomplicated T2DM.Fifteen individual BAs were quantified in fasting serum using liquid chromatography-tandem mass spectrometry.Gastrointestinal symptoms were scored using the Gastrointestinal Symptom Rating Scale.Spearman’s correlation,multivariable logistic regression,receiver operating characteristic,and decision curve analyses were used to explore the associations and build a predictive nomogram.RESULTS Orthogonal partial least squares discriminant analysis of serum BAs revealed clear separation between the T2DM and DGAN groups,identifying taurolithocholic acid(TLCA)as the key discriminator(variable importance in projection>1,fold change<0.5).Univariate logistic regression identified age,body mass index,hemoglobin,fasting/2-h C-peptide,albumin,and TLCA levels as protective factors and the urinary albumin-to-creatinine ratio as a risk factor.After multivariate adjustment age,fasting C-peptide levels,and TLCA levels remained independently associated with DGAN.Receiver operating characteristic analysis yielded areas under the curve of 0.651,0.760,and 0.678 for age,fasting C-peptide,and TLCA,respectively,and the three variables collectively had an area under the curve of 0.970(95%confidence interval:0.937-1.000).Decision curve analysis confirmed the clinical net benefit across threshold probabilities of 9%-68%.The derived nomogram displayed excellent calibration and net clinical benefits for the model.CONCLUSION These findings highlighted the association between altered BA profiles and DGAN in patients with T2DM.Combining BA profiling with conventional clinical data could facilitate the early identification of DGAN and offer new insights into early screening and BA-targeted interventions.While these findings offer valuable insights,they should nevertheless be viewed as hypothesis-generating and require further validation in larger,multicenter cohorts. 展开更多
关键词 Type 2 diabetes mellitus Diabetic gastrointestinal autonomic neuropathy Serum bile acids profiles Gastrointestinal Symptom Rating Scale
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Impact of autonomic nerve-oriented anatomical laparoscopic surgery on recovery in patients with colorectal cancer 认领 引用
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作者 Jian-Zhong Yi Yun-Geng Liu +1 位作者 Chuan-Yuan Liu Chuan-Fa Fang 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第5期209-214,共6页
BACKGROUND Implementation of an autonomic nerve-oriented anatomical approach in laparo-scopic surgery for patients with colorectal cancer may provide a new reference for surgical intervention in this patient populatio... BACKGROUND Implementation of an autonomic nerve-oriented anatomical approach in laparo-scopic surgery for patients with colorectal cancer may provide a new reference for surgical intervention in this patient population.AIM To assess the impact of autonomic nerve-oriented anatomical laparoscopic surgery on recovery and postoperative risks in patients with colorectal cancer.METHODS Data from 116 patients diagnosed with colorectal cancer,treated between January 2016 and May 2024,were randomly divided into 2 groups(n=58 each)according to surgical approach:Control(radical vessel-oriented laparoscopic surgery);and Observation(autonomic nerve-oriented anatomical surgery).Perioperative in-dicators,and postoperative risk for urinary dysfunction and sexual function were compared between the 2 groups.RESULTS Compared with the control group,the observation group experienced less in-traoperative blood loss(P<0.05)and exhibited superior perioperative indicators(P<0.05).At 2 weeks and 3 months postoperatively,the proportion of patients with urinary dysfunction in the observation group was lower than that in the control group(P<0.05).Four months postoperatively,there were significant differences in male erectile dysfunction,female dyspareunia,and sexual pleasure grading between the 2 groups(P<0.05).CONCLUSION The autonomic nerve-oriented anatomical approach to laparoscopic surgery for colorectal cancer accelerates postoperative recovery,with decreased intraope-rative blood loss,lower impact on urinary and sexual functions,and enhances surgical safety. 展开更多
关键词 Colorectal cancer Autonomic nerve Laparoscopic surgery Urinary dysfunction Sexual function
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Comorbid depression and autonomic dysfunction reduce lung function in patients with chronic obstructive pulmonary disease 认领 引用
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作者 Jiang-Bo Li Wei Rong 《World Journal of Psychiatry》 SCIE 2025年第12期1-8,共8页
The high comorbidity rates of depression and chronic obstructive pulmonary disease(COPD)have garnered widespread attention.As a refractory disease,its long-term stress effects exacerbate the coexistence of depression.... The high comorbidity rates of depression and chronic obstructive pulmonary disease(COPD)have garnered widespread attention.As a refractory disease,its long-term stress effects exacerbate the coexistence of depression.Depression is linked to a decline in lung function in patients with COPD through reduced heart rate variability,increased inflammatory cytokines,dysregulation of the hypothalamic-pituitary-adrenal axis,and the interplay of various biological and psychological factors.Sole reliance on biomedical treatment cannot fully counteract these negative effects,which are detrimental to improving patients’quality of life and long-term prognosis.Antidepressant medications and traditional Chinese medicine combined with conventional COPD therapy,psychotherapy(e.g.,cognitive behavioral therapy,mindfulness training),and lifestyle adjustments(e.g.,yoga,qigong,or walking)can not only alleviate depression and compensate for the limitations of biomedical approaches but also help improve heart rate variability and lung function.In this editorial,we suggest that clinicians,when prescribing antidepressants,must carefully weigh the benefit-risk ratio based on the patient’s specific physical condition to ensure precise medication use. 展开更多
关键词 Chronic obstructive pulmonary disease Depression Lung function Heart rate variability Autonomic dysfunction Antidepressants
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Cardiovascular autonomic neuropathy in diabetes:Pathophysiology,clinical assessment and implications 认领 引用 被引量：30
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作者 Alice Duque Mauro Felippe Felix Mediano +1 位作者 Andrea De Lorenzo Luiz Fernando Rodrigues Jr 《World Journal of Diabetes》 SCIE 2021年第6期855-867,共13页
Cardiovascular autonomic neuropathy(CAN)is a debilitating condition that mainly occurs in long-standing type 2 diabetes patients but can manifest earlier,even before diabetes is diagnosed.CAN is a microvascular compli... Cardiovascular autonomic neuropathy(CAN)is a debilitating condition that mainly occurs in long-standing type 2 diabetes patients but can manifest earlier,even before diabetes is diagnosed.CAN is a microvascular complication that results from lesions of the sympathetic and parasympathetic nerve fibers,which innervate the heart and blood vessels and promote alterations in cardiovascular autonomic control.The entire mechanism is still not elucidated,but several aspects of the pathophysiology of CAN have already been described,such as the production of advanced glycation end products,reactive oxygen species,nuclear factor kappa B,and pro-inflammatory cytokines.This microvascular complication is an important risk factor for silent myocardial ischemia,chronic kidney disease,myocardial dysfunction,major cardiovascular events,cardiac arrhythmias,and sudden death.It has also been suggested that,compared to other traditional cardiovascular risk factors,CAN progression may have a greater impact on cardiovascular disease development.However,CAN might be subclinical for several years,and a late diagnosis increases the mortality risk.The duration of the transition period from the subclinical to clinical stage remains unknown,but the progression of CAN is associated with a poor prognosis.Several tests can be used for CAN diagnosis,such as heart rate variability(HRV),cardiovascular autonomic reflex tests,and myocardial scintigraphy.Currently,it has already been described that CAN could be detected even during the subclinical stage through a reduction in HRV,which is a non-invasive test with a lower operating cost.Therefore,considering that diabetes mellitus is a global epidemic and that diabetic neuropathy is the most common chronic complication of diabetes,the early identification and treatment of CAN could be a key point to mitigate the morbidity and mortality associated with this long-lasting condition. 展开更多
关键词 Cardiovascular autonomic neuropathy Cardiac autonomic neuropathy Diabetes mellitus Heart rate variability Sympathetic autonomic nervous system Parasym-pathetic autonomic nervous system
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An integrative review of the effects of high-intensity interval training on the autonomic nervous system 认领 引用
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作者 Massimo Coretti Nathalia Nahas Donatello +1 位作者 Gianluca Bianco Francisco J.Cidral-Filho 《Sports Medicine and Health Science》 CSCD 2025年第2期77-84,共8页
High-Intensity Interval Training(HIIT)has gained prominence as a time-efficient and effective exercise modality to improve cardiovascular(CV)fitness,metabolic health,and physical performance.Therefore,our aim was to s... High-Intensity Interval Training(HIIT)has gained prominence as a time-efficient and effective exercise modality to improve cardiovascular(CV)fitness,metabolic health,and physical performance.Therefore,our aim was to synthesize current clinical research on the effects of HIIT on the Autonomic Nervous System.We conducted the search for studies in the Directory of Open Access Journals,Embase,Virtual Health Library,Pubmed,and Scielo databases,in January of 2024.We included a total of 20 studies in our review.This literature review highlights the potential of HIIT to modulate the Autonomic Nervous System,enhancing CV function and overall health.Despite the promising findings,the interpretation of the results is tempered by the variability in study designs,populations,and methodologies.Future research should address these limitations,aiming for a more nuanced understanding of the relationship between HIIT and Autonomic Nervous System function.The review indicates that standardized protocols need to consider individual characteristics and baseline autonomic states for clinical application.As the body of evidence grows,HIIT may emerge as a cornerstone of exercise prescriptions aimed at optimizing autonomic function and promoting CV health. 展开更多
关键词 High intensity interval training Exercise Autonomic nervous system Health
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Chronic heart failure and heart transplantation:The relationship between autonomic function and cardiac performance 认领 引用
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作者 Lin-Zhi Wu Yi-Ning Huang +7 位作者 Yue Chen Yu-Qiu Ji Yi-Wen Jin Cai-Xian Chen Si-Yu Zhuang Bin Xu You-Bing Xia Tian-Cheng Xu 《World Journal of Transplantation》 2025年第4期179-186,共8页
Chronic heart failure(CHF)is a complex clinical syndrome characterized byimpaired cardiac function and neurohormonal dysregulation.While CHF hastraditionally been regarded as a hemodynamic disorder,growing evidencehig... Chronic heart failure(CHF)is a complex clinical syndrome characterized byimpaired cardiac function and neurohormonal dysregulation.While CHF hastraditionally been regarded as a hemodynamic disorder,growing evidencehighlights the pivotal role of autonomic nervous system(ANS)dysfunction in itsprogression and prognosis.The ANS,comprising sympathetic and parasympatheticbranches,exerts significant control over cardiac function,including heartrate,contractility,and vascular tone.In CHF,sympathetic overactivation coupledwith parasympathetic withdrawal contributes to adverse cardiac remodeling,arrhythmogenesis,and further deterioration of cardiac performance.This minireviewsummarizes current knowledge on the role of autonomic dysfunction inCHF and heart transplantation.It focuses on how sympathetic nervous systemimbalance contributes to CHF progression and explores the impact of autonomicdysregulation on post-transplant outcomes.By synthesizing existing evidence,thereview highlights ANS modulation as a key therapeutic target for improvingcardiac function and patient prognosis in both clinical settings. 展开更多
关键词 Chronic heart failure Autonomic nervous system Heart transplantation Sympathetic nervous system Parasympathetic nervous system
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Is cardiac autonomic modulation influenced by beta blockers in adolescents with Duchenne Muscular Dystrophy? 认领 引用
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作者 Talita Dias da Silva-Magalhaes Ibis Ariana Pena de Moraes +8 位作者 Luiz Carlos Marques Vanderlei Carlos Bandeira de Mello Monteiro Marcela Maria Carvalho da Silva Fernando Pereira Rodrigo Martins Dias David Garner Luis Fernando Grossklauss Tatiana Dias de Carvalho Celso Ferreira 《Translational Exercise Biomedicine》 2025年第2期63-73,共11页
Objectives:As the Duchenne Muscular Dystrophy(DMD)is a progressive neuromuscular disorder frequently associated with cardiac dysfunction,this study aimed to evaluate the influence of beta-blocker therapy on cardiac au... Objectives:As the Duchenne Muscular Dystrophy(DMD)is a progressive neuromuscular disorder frequently associated with cardiac dysfunction,this study aimed to evaluate the influence of beta-blocker therapy on cardiac autonomic modulation in adolescents withDMDby analyzing heart rate variability(HRV)indices in patients with and without betablockers.Methods:A cross-sectional study was conducted with 90 participants divided into three groups:(1)participants with DMD receiving beta-blocker therapy(DMDB,n=30),(2)participants with DMD without beta-blocker therapy(GMDM,n=30),and(3)age-and sex-matched typically developing participants(GDT,n=30).HRV was assessed using validated beat-to-beat heart rate monitoring(RS800CX,Polar)under controlled conditions.Linear and non-linear HRV indices(including Detrended Fluctuation Analysis and Symbolic Dynamics)were analysed using Kubios HRV software.Results:DMD patients exhibited autonomic impairment,characterized by decreased HRV,increased sympathetic dominance,and reduced parasympathetic modulation.Betablocker therapy was associated with significantly higher Mean Beat-to-beat interval(RR)and lower Mean Heart Rate(HR)compared to the non-beta-blocker DMD group,with values approaching those observed in typically developing participants.Non-linear indices suggested thatDMDpatients receiving beta-blockers demonstrated increased HRV complexity and fractal properties compared to those not receiving beta-blockers,although differences remained between the DMD and control groups.Conclusions:Autonomic dysfunction in DMD is characterized by reduced HRV and altered sympathovagal balance.In our results,beta-blocker therapy was associated with improved HRV and enhanced autonomic control.These findings highlight the potential cardioprotective role of betablockers in DMD management and emphasize the need for further research into optimizing autonomic function in DMD. 展开更多
关键词 Muscular Dystrophy Duchenne heart rate autonomic nervous system adrenergic beta-antagonists
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Effects of Adjusting Backpack Shoulder Stabilizers on Psychological Responses and Autonomic Nerve Activity in Hiking 认领 引用
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作者 Hisashi Mitsuishi Mikitoshi Tabuchi 《Health》 2025年第1期1-12,共12页
Purpose: There have been many studies on the effects of different types of backpacks on posture from a biomechanical perspective and on the center of gravity. Considering the effects of autonomic nervous system activi... Purpose: There have been many studies on the effects of different types of backpacks on posture from a biomechanical perspective and on the center of gravity. Considering the effects of autonomic nervous system activity and mood associated with backpacks in mountaineering and hiking, research is also needed from a psychological perspective. In this study, the effects of adjusting the backpack shoulder stabilizer were preliminarily tested in terms of subjective fatigue and changes in autonomic nervous activity after hiking. Methods: The experimental 15 healthy participants hiked the mountain under two conditions: 1) without adjusting the stabilizer, a feature of the backpack (NAH condition), and 2) with the stabilizer adjusted (AH condition). First, all participants hiked the mountain in the NAH condition, and after a 30-minute break, they began the hike in the AH condition after confirming that a) their heart rate had recovered and b) they were in good physical condition. Results: HR was significantly lower after each hiking session than during the session. RMSSD was significantly lower pre-AH and post-AH than the NAH condition, but there was no significant difference between the NAH condition and either post-NAH or post-AH. Additionally, RMSSD was significantly lower in the AH condition than pre-AH or post-AH. The shoulders and back were significantly more burdened in the NAH condition than in the AH condition. The pleasure level was significantly higher in the AH condition than in the NAH condition. Conclusion: The results showed that also adjusting the position of the waist belt when adjusting the shoulder stabilizer, which is mainly used for the neck and shoulders, has a significant positive effect on the subjective burden on the upper body and parasympathetic nervous system activity after hiking. 展开更多
关键词 Shoulder Stabilizer Autonomic Nervous System RMSSD Pleasure Level
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Need for combined therapy for a rare case of autoimmune autonomic ganglionopathy:A case report 认领 引用
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作者 Elena Angeloudi Maria Xanthopoulou +6 位作者 Maria Lima Athanasios C Kalyvas Serafeim C Kotoulas Maria Dimitriou Panagiotis Ioannidis Aris Liakos Eleni Gigi 《World Journal of Methodology》 2025年第4期411-416,共6页
BACKGROUND Autoimmune autonomic ganglionopathy(AAG),formerly known as acute pandysautonomia,is a rare,acquired,antibody-mediated,potentially curable autonomic disorder that presents with diffuse autonomic failure.High... BACKGROUND Autoimmune autonomic ganglionopathy(AAG),formerly known as acute pandysautonomia,is a rare,acquired,antibody-mediated,potentially curable autonomic disorder that presents with diffuse autonomic failure.High levels of anti-ganglionic nicotinic acetylcholine receptor(gAChR)serum antibodies are detected in approximately 50%of AAG cases,confirming the diagnosis.CASE SUMMARY We present the case of a 68-year-old man who developed autonomic failure gradually over a 2-year period.Recently,the patient was unable to stand upright for more than a few seconds before fainting.Additionally,he presented with decreased sweating,dry mouth,urinary retention,early satiety,weight loss,bloating,constipation,and erectile dysfunction.Neurological examination revealed dilated pupils that were unresponsive to light.Deep tendon reflexes were absent or diminished.Serologic evaluation revealed the presence of gAChR autoantibodies.An orthostatic hypotension test yielded a positive result.The patient did not respond to symptomatic therapy,including midodrine,fludrocortisone and atomoxetine.Second-line therapy with immunoadsorption produced a noticeable clinical improvement;however,orthostatic hypotension persisted.Sequential rituximab infusion therapy successfully led to a significant improvement in symptoms.CONCLUSION Our case report supports the benefit of combined immunomodulatory therapy for refractory AAG cases that are unresponsive to single-agent treatment. 展开更多
关键词 Autoimmune autonomic ganglionopathy Immunoadsorption Combined immunomodulatory therapy Refractory autoimmune symptoms Rituximab Case report
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COVID-19-induced gastrointestinal autonomic dysfunction:A systematic review 认领 引用 被引量：3
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作者 Reem Elbeltagi Mohammed Al-Beltagi +1 位作者 Nermin Kamal Saeed Adel Salah Bediwy 《World Journal of Clinical Cases》 SCIE 2023年第22期5252-5272,共21页
BACKGROUND It is common for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection to occur in the gastrointestinal tract,which can present itself as an initial symptom.The severity of coronavirus diseas... BACKGROUND It is common for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection to occur in the gastrointestinal tract,which can present itself as an initial symptom.The severity of coronavirus disease 2019(COVID-19)is often reflected in the prevalence of gastrointestinal symptoms.COVID-19 can damage the nerve supply to the digestive system,leading to gastrointestinal autonomic dysfunction.There is still much to learn about how COVID-19 affects the autonomic nervous system and the gastrointestinal tract.AIM To thoroughly explore the epidemiology and clinical aspects of COVID-19-induced gastrointestinal autonomic dysfunction,including its manifestations,potential mechanisms,diagnosis,differential diagnosis,impact on quality of life,prognosis,and management and prevention strategies.METHODS We conducted a thorough systematic search across various databases and performed an extensive literature review.Our review encompassed 113 studies published in English from January 2000 to April 18,2023.RESULTS According to most of the literature,gastrointestinal autonomic dysfunction can seriously affect a patient's quality of life and ultimate prognosis.Numerous factors can influence gastrointestinal autonomic nervous functions.Studies have shown that SARS-CoV-2 has a well-documented affinity for both neural and gastrointestinal tissues,and the virus can produce various gastrointestinal symptoms by reaching neural tissues through different pathways.These symptoms include anorexia,dysgeusia,heartburn,belching,chest pain,regurgitation,vomiting,epigastric burn,diarrhea,abdominal pain,bloating,irregular bowel movements,and constipation.Diarrhea is the most prevalent symptom,followed by anorexia,nausea,vomiting,and abdominal pain.Although COVID-19 vaccination may rarely induce autonomic dysfunction and gastrointestinal symptoms,COVID-19-induced autonomic effects significantly impact the patient's condition,general health,prognosis,and quality of life.Early diagnosis and proper recognition are crucial for improving outcomes.It is important to consider the differential diagnosis,as these symptoms may be induced by diseases other than COVID-19-induced autonomic dysfunction.Treating this dysfunction can be a challenging task.CONCLUSION To ensure the best possible outcomes for COVID-19 patients,it is essential to take a multidisciplinary approach involving providing supportive care,treating the underlying infection,managing dysfunction,monitoring for complications,and offering nutritional support.Close monitoring of the patient's condition is crucial,and prompt intervention should be taken if necessary.Furthermore,conducting thorough research on the gastrointestinal autonomic dysfunction caused by COVID-19 is vital to manage it effectively. 展开更多
关键词 COVID-19 SARS-CoV-2 Gastrointestinal autonomic dysfunction Long COVID Post-COVID Autonomic nervous system
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Activities of autonomic neurotransmitters in meibomian gland tissues are associated with menopausal dry eye 认领 引用 被引量：1
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作者 Lianxiang Li Dongling Jin +4 位作者 Jinsheng Gao Liguang Wang Xianjun Liu Jingzhang Wang Zhongxin Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第35期2761-2769,共9页
The secretory activities of meibomian glands are regulated by the autonomic nervous system, The change in density and activity of autonomic nerves in meibomian glands during menopause play an important role in the pat... The secretory activities of meibomian glands are regulated by the autonomic nervous system, The change in density and activity of autonomic nerves in meibomian glands during menopause play an important role in the pathogenesis of dry eye. In view of this, we established a dry eye rat model by removing the bilateral ovaries. We used neuropeptide Y and vasoactive intestinal polypeptide as markers of autonomic neurotransmitters. Our results showed that the concentration of estradiol in serum significantly decreased, the density of neuropeptide Y immunoreactivity in nerve fibers significantly increased, the density of vasoactive intestinal polypeptide immunoreactivity in nerve fibers significantly decreased, and the ratio of vasoactive intestinal polypeptideeuropeptide Y positive staining significantly decreased. These results suggest that a decrease in ovary activity may lead to autonomic nervous system dysfunction, thereby affecting the secretory activity of the meibomian gland, which participates in sexual hormone imbalance-induced dry eye. 展开更多
关键词 ovariectomy meibomian gland meibomian gland dysfunction neuropeptide Y vasoactive intestinalpolypeptide autonomic nervous system dysfunction dry eye sexual hormone rats autonomicnerve neural regeneration
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Autonomic Disturbances in Acute Cerebrovascular Disease 认领 引用 被引量：13
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作者 Jun Mo Lei Huang +3 位作者 Jianhua Peng Umut Ocak Jianmin Zhang John H.Zhang 《Neuroscience Bulletin》 SCIE CAS CSCD 2019年第1期133-144,共12页
Autonomic disturbances often occur in patients with acute cerebrovascular disease due to damage of the central autonomic network. We summarize the structures of the central autonomic network and the clinical tests use... Autonomic disturbances often occur in patients with acute cerebrovascular disease due to damage of the central autonomic network. We summarize the structures of the central autonomic network and the clinical tests used to evaluate the functions of the autonomic nervous system.We review the clinical and experimental findings as well as management strategies of post-stroke autonomic disturbances including electrocardiographic changes, cardiac arrhythmias, myocardial damage, thermoregulatory dysfunction, gastrointestinal dysfunction, urinary incontinence, sexual disorders, and hyperglycemia. The occurrence of autonomic disturbances has been associated with poor outcomes in stroke patients. Autonomic nervous system modulation appears to be an emerging therapeutic strategy for stroke management in addition to treatments for sensorimotor dysfunction. 展开更多
关键词 Autonomic disturbance Autonomic nervous system Cerebrovascular disease Stroke
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Visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction and low-grade inflammation in a subset of irritable bowel syndrome patients 认领 引用 被引量：20
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作者 Liang LIU Bei-ni LIU +4 位作者 Shuo CHEN Miao WANG Yang LIU Yan-li ZHANG Shu-kun YAO 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2014年第10期907-914,共8页
The pathophysiology of irritable bowel syndrome（IBS） is complex and not fully understood, so the aim of this study was to evaluate whether visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction,... The pathophysiology of irritable bowel syndrome（IBS） is complex and not fully understood, so the aim of this study was to evaluate whether visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction, and low-grade inflammation of the gut wall are associated with diarrhea-predominant IBS（D-IBS）. Sixty-two patients with D-IBS and 20 control subjects participated in the study. Using the ascending method of limits（AML） protocol, we demonstrated that D-IBS patients had significantly lower sensory thresholds compared with healthy controls（P〈0.001）. Using diverse methods, especially the ischemic sensitivity test, for the first time in China, we confirmed that D-IBS patients have somatic hypersensitivity. They had a significantly higher systolic blood pressure and heart rate after a cold stimulus, indicative of autonomic cardiovascular dysfunction. Compared with the control group, D-IBS patients had a significantly higher level of calprotectin（P〈0.001）. We also found significant correlations between visceral and somatic hypersensitivity, visceral hypersensitivity and autonomic cardiovascular dysfunction, and somatic hypersensitivity and autonomic cardiovascular dysfunction. Our findings may provide valuable suggestions for the treatment of D-IBS. 展开更多
关键词 Irritable bowel syndrome（IBS） Visceral hypersensitivity Somatic hypersensitivity Autonomic cardiovascular dysfunction Low-grade inflammation
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Decreased b-Cell Function is Associated with Cardiovascular Autonomic Neuropathy in Chinese Patients Newly Diagnosed with Type 2 Diabetes 认领 引用 被引量：8
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作者 Xubin Yang Wen Xu +4 位作者 Yanhua Zhu Hongrong Deng Ying Tan Longyi Zeng Jianping Weng 《Neuroscience Bulletin》 SCIE CAS CSCD 2019年第1期25-33,共9页
The influence of b-cell function on cardiovascular autonomic neuropathy(CAN), an important diabetesrelated complication, is still unclear. In this study, we aimed to investigate the association between residual b-cell... The influence of b-cell function on cardiovascular autonomic neuropathy(CAN), an important diabetesrelated complication, is still unclear. In this study, we aimed to investigate the association between residual b-cell function and CAN in patients newly diagnosed with type 2 diabetes. We enrolled 90 newly-diagnosed type 2 diabetic patients and 37 participants with normal glucose tolerance as controls. The patients were divided into a CAN? group(diabetic patients with CAN, n = 20) and a CAN-group(diabetic patients without CAN, n = 70) according to the standard Ewing battery of tests. Fasting and postprandial plasma glucose, insulin, and C-peptide were measured.Homeostasis model assessment-beta cells(HOMA-B) and HOMA-insulin resistance(IR) were calculated. The prevalence of CAN in this population was 22.2%. Compared with the CAN-group, the CAN? group had significantly lower fasting plasma insulin(6.60 ± 4.39 vs 10.45 ± 7.82 l/L, P = 0.029), fasting C-peptide(0.51 ± 0.20 vs0.82 ± 0.51 nmol/L, P = 0.004), and HOMA-B(21.44 ± 17.06 vs 44.17 ± 38.49, P = 0.002). Fasting C-peptide was correlated with the Valsalva ratio(r = 0.24, P = 0.043) and the 30:15 test(r = 0.26,P = 0.023). Further analysis showed that fasting C-peptide(OR: 0.041, 95% CI 0.003–0.501, P = 0.012) and HOMAB(OR: 0.965, 95% CI 0.934–0.996, P = 0.028) were independently associated with cardiovascular autonomic nerve function in this population. The patients with fasting C-peptide values \ 0.67 nmol/L were more likely to have CAN than those with C-peptide levels C0.67 nmol/L(OR:6.00, 95% CI 1.815–19.830, P = 0.003). A high prevalence of CAN was found in patients with newly-diagnosed type 2 diabetes. Decreased b-cell function was closely associated with CAN in this population. 展开更多
关键词 Cardiovascular autonomic neuropathy b-cell function Type 2 diabetes mellitus
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Cardiac autonomic nerve fiber regeneration in chronic heart failure Do Akt gene-transduced mesenchymal stem cells promote repair? 认领 引用 被引量：13
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作者 Hongliang Kong Zhanquan Li +7 位作者 Shumei Zhao Li Zhu Yingjun Zhao Weiwei Zhang GuipingXu Wenjun Hao Huijun Li Guoxian Qi 《Neural Regeneration Research》 SCIE CAS 2010年第1期28-34,共7页
BACKGROUND： Transplantation of Akt-over-expressing mesenchymal stem ceils （Akt-MSCs） has been shown to repair infarcted myocardium and improve cardiac function. However, little is known about the therapeutic effect... BACKGROUND： Transplantation of Akt-over-expressing mesenchymal stem ceils （Akt-MSCs） has been shown to repair infarcted myocardium and improve cardiac function. However, little is known about the therapeutic effects of Akt-MSCs on cardiac autonomic neuropathy in chronic heart failure （CHF）. OBJECTIVE： The present study used adriamycin-induced CHF rat models to observe the effect of Akt-MSCs on cardiac autonomic nervous regeneration and the factors mediating this effect. DESIGN, TIME AND SETTING： A randomized, controlled animal experiment was performed at the Central Laboratory of Basic Medical College, China Medical University, between September 2008 and April 2009. MATERIALS： Rabbit anti-choline acetyltransferase （CHAT）, growth associated protein-43 （GAP-43） synaptophysin （SYN） polyclonal antibodies and the secondary antibody （goat anti-rabbit IgG） were purchased from Boster, China. Cat-A-Kit assay system was provided by Amersham, USA. METHODS： （1） Adult rat MSCs were isolated and cultured for the preparation of Akt-MSCs. （2） Forty male Wistar rats were intramyocardially administered adriamycin at 2 mg/kg over 3 days for a total of five times and once a week for additional five times thereafter to establish CHF models. At 2 weeks after final adriamycin treatment, 34 successful CHF rat models were randomized to three groups： Akt-MSCs （n = 11）, simple MSCs （s-MSCs, n =11）, and control （n = 12）. Each group was intravenously administered Akt-MSCs （2x106 cells in 100 IJL PBS）, s-MSCs （2×10^6 cells in 100 μL PBS） or equal volume of phosphate buffered saline, once a day for a total of three times. MAIN OUTCOME MEASURES： At 4 weeks after final adriamycin treatment, myocardial norepinephrine （NE） content was detected using a Cat-A-Kit assay system. Myocardial CHAT, SYN and GAP-43 were performed by immunohistochemistry and Western blot analysis. Prior to, 2 and 4 weeks after adriamycin treatment, echocardiographic examination was performed and left ventricular ejection fraction （LVEF） was determined. RESULTS： Myocardial NE content, as well as SYN-positive and GAP-43-positive nerve fiber density and expression, and LVEF, was the greatest in the Akt-MSCs group, followed by the s-MSCs group, and lastly the control group （P 〈 0.05 or P 〈 0.01）. ChAT expression was similar between Akt-MSCs and s-MSCs groups, but it was higher compared with the control group （P 〈 0.05）. NE contents were negatively correlated to LVEF （r = -0.64, P = 0.015）. CONCLUSION： Transplantation of MSCs, in particular Akt-MSCs, promotes cardiac nervous regeneration in failing heart, which might be mediated by GAP-43. 展开更多
关键词 mesenchymal stem cells Akt gene transfection chronic heart failure neural regeneration autonomic nerve system
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Positive effects of music therapist's selected auditory stimulation on the autonomic nervous system of patients with disorder of consciousness: a randomized controlled trial 认领 引用 被引量：8
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作者 Xiao-Ying Zhang Jian-Jun Li +2 位作者 Hai-Tao Lu Wen-Jia Teng Song-Huai Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第7期1266-1272,共7页
The current randomized controlled trial was performed at the China Rehabilitation Science Institute, China to test the hypothesis that musical auditory stimulation has positive effects on the autonomic nervous system ... The current randomized controlled trial was performed at the China Rehabilitation Science Institute, China to test the hypothesis that musical auditory stimulation has positive effects on the autonomic nervous system of patients with disorder of consciousness.Although past studies have recommended that patients with disorder of consciousness listen to patient-preferred music, this practice is not universally accepted by researchers.Twenty patients with severe disorder of consciousness listened to either therapist-selected(n = 10, 6 males and 4 females;43.33 ± 18.76 years old) or patient-preferred(n = 10, 5 males and 5 females, 48.83 ± 18.79 years old) musical therapy, 30 minutes/day, 5 times/week for 6 weeks.The results showed no obvious differences in heart rate variability-related parameters including heart rate, standard deviation of normal-to-normal R-R intervals, and the root-mean-square of successive heartbeat interval differences of successive heartbeat intervals between the two groups of patients.However, percentage of differences exceeding 50 ms between adjacent normal number of intervals, low-frequency power/high-frequency power, high-frequency power norm, low-frequency power norm, and total power were higher in patients receiving therapist-selected music than in patients receiving their own preferred music.In contrast, this relationship was reversed for the high-frequency power and very-low-frequency band.These results suggest that compared with preferred musical stimulation, therapist-selected musical stimulation resulted in higher interactive activity of the autonomic nervous system.Therefore, therapist-selected musical stimulation should be used to arouse the autonomic nervous system of patients with disorder of consciousness.This study was approved by the Institutional Ethics Committee of China Rehabilitation Research Center, China(approval No.2018-022-1) on March 12, 2018 and registered with the Chinese Clinical Trial Registry(registration number Chi CTR1800017809) on August 15, 2018. 展开更多
关键词 auditory autonomic nerve system disorder of consciousness heart rate misdiagnosis music therapy protection repair subjective score
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Autonomic Nervous Function in Vasovagal Syncope of Children and Adolescents 认领 引用 被引量：7
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作者 Chunyan Tao Chaoshu Tang +2 位作者 Selena Chen Hongfang Jin Junbao Du 《Neuroscience Bulletin》 SCIE CAS CSCD 2019年第5期937-940,共4页
Syncope is defined as a transient loss of consciousness due to global cerebral hypoperfusion, accompanied by loss of muscle tone and failure to maintain an active position. Vasovagal syncope (VVS) is the most common p... Syncope is defined as a transient loss of consciousness due to global cerebral hypoperfusion, accompanied by loss of muscle tone and failure to maintain an active position. Vasovagal syncope (VVS) is the most common presentation of syncope, and its diagnostic criteria include:(1) absence of any other evident etiology for syncope or presyncope,(2) positive response to head-up tilt test with evident vasovagal reaction (hypotension and/or bradycardia), and (3) no concomitant chronic or acute disease [1, 2]. The onset of VVS peaks initially in childhood and adolescence, and accounts for 60%–70% of all syncopal cases. Clinicians pay great attention to syncope among children and adolescents, due to its high prevalence and its impact on patients’ quality of life. Affected individuals often experience mental stress, economic burdens, and accidental bodily injuries related to syncope [2]. While the pathogenesis of VVS is not fully understood, autonomic nervous dysfunction has been identified as a contributing mechanism. The examination of autonomic nervous function can provide important information about patients with syncope. 展开更多
关键词 Autonomic Nervous Function Vasovagal Syncope Children Adolescents
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Autonomic nervous system network and liver regeneration 认领 引用 被引量：6
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作者 Kenya Kamimura Ryosuke Inoue +5 位作者 Takuro Nagoya Norihiro Sakai Ryo Goto Masayoshi Ko Yusuke Niwa Shuji Terai 《World Journal of Gastroenterology》 SCIE CAS 2018年第15期1616-1621,共6页
To date, various signal transducers, cytokines, growth factors, and hormones have been reported to play an important role in homeostasis of various organs. Various cells and organs are involved in the hepatic regenera... To date, various signal transducers, cytokines, growth factors, and hormones have been reported to play an important role in homeostasis of various organs. Various cells and organs are involved in the hepatic regeneration process, which proceeds as a result of the coordination of many factors. While these factors are well known to be involved in the liver regeneration after the liver injury, however, as the details of such mechanisms have not been sufficiently elucidated, the practical applicability of hepatic regeneration based on the action of these and cytokines growth factors is still unclear. In terms of the involvement of the autonomic nervous system in hepatic regeneration, cell proliferation resulting from direct signal transduction to the liver has also been reported and recent studies focusing on the inter-organ communication via neural network opened a novel aspect of this field for therapeutic applicability. Therefore, the appropriate understanding of the relationship between autonomic neural network and liver regeneration through various organs including brain, afferent nerve, efferent nerve, etc. is essential. This mini-review explains the principle of neural system involved in the inter-organ communication and its contribution on the liver regeneration upon the liver injury reviewing recent progress in this field. 展开更多
关键词 Autonomic nerve Neural network Liver regeneration Hormone
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Influence of Acupuncture on Autonomic Balance in Adult Tinnitus Patients:An Exploratory Study 认领 引用 被引量：7
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作者 Jian-feng TU Mirim Kim +6 位作者 Jing-wen YANG Qian-qian LI Gerhard Litscher Lu WANG Guang-xia SHI Daniela Litscher Cun-zhi LIU 《Current Medical Science》 SCIE CAS 2019年第6期947-953,共7页
Acupuncture is an alternative therapy for tinnitus in clinical practice.The mechanism by which acupuncture can alleviate tinnitus is still unknown.Autonomic nervous system was reported to be responsible for tinnitus.T... Acupuncture is an alternative therapy for tinnitus in clinical practice.The mechanism by which acupuncture can alleviate tinnitus is still unknown.Autonomic nervous system was reported to be responsible for tinnitus.The aim of this study was to explore the effect of acupuncture on autonomic balance in adult tinnitus patients.Thirty patients were randomly assigned into either the deep acupuncture(DA)group or the shallow acupuncture(SA)group.Each patient received 6 acupuncture sessions(a-f phase)over three weeks.Measures of heart rate variability and Tinnitus Handicap Inventory(THI)were obtained at baseline and after the sixth acupuncture session in all patients.The results showed that the low frequency/high frequency(LF/HF)pattern was increased at b-f phase until the sixth acupuncture session when compared with that at the first acupuncture session in DA group.However,it continuously increased at b-f phase in SA group even at the sixth acupuncture session,which was not significantly different from that at the first acupuncture session.The decrease in THI in DA group was greater than that in SA group after 3-week treatment(P=0.043).Our preliminary study suggests three-week deep acupuncture can improve tinnitus symptoms in adult tinnitus patients,which may be related to the regulation of autonomic nervous system balance. 展开更多
关键词 tinnitus acupuncture heart rate variability autonomic nervous system
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