期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到88篇文章
< 1 2 … 5 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Polymer Materials Synthesized in Living Cells for Regulating Biological Functions 认领 引用
1
作者 Cheng-Fei Liu Yi-Fan Jin +2 位作者 Jia-Hui Ma Wei Tian Hua-Ping Xu 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2025年第8期1293-1310,共18页
Intracellular polymerization is an emerging field,showcasing high diversity and efficiency of chemistry.Motivated by the principles of natural biomolecular synthesis,polymerization within living cells is believed to b... Intracellular polymerization is an emerging field,showcasing high diversity and efficiency of chemistry.Motivated by the principles of natural biomolecular synthesis,polymerization within living cells is believed to be a powerful and versatile tool to modulate cell behavior.In this review,we summarized recent advances and future trends in the field of intracellular polymerization,specifically focusing on covalent and supramolecular polymerization.This discussion comprehensively covers the diverse chemical designs,reaction mechanisms,responsive features,and functional applications.Furthermore,we also clarified the connection between preliminary design of polymer synthesis and their subsequent biological applications.We hope this review will serve as an innovative platform for chemists and biologists to regulate biological functions in practical applications and clinical trials. 展开更多
关键词 Intracellular polymerization Covalent bonding Supramolecular interaction Functional Polymer Materials Biological functions
暂未订购 下载PDF
Biological Functions of Active Components of Melaleuca alternifolia Essential Oil and Their Applications in Agricultural Pest Control 认领 引用
2
作者 Fengmei YANG Ranran NIE +5 位作者 Yourong FU Yuyun LIAO Bingkun CHEN Qiwei ZHANG Qianhua JI Yanjun GUO 《Plant Diseases and Pests》 2025年第1期1-5,共5页
This paper systematically introduces the extraction process of the active components from the essential oil of Melaleuca alternifolia,elucidates the biological functions of these active components,and summarizes their... This paper systematically introduces the extraction process of the active components from the essential oil of Melaleuca alternifolia,elucidates the biological functions of these active components,and summarizes their applications in agricultural pest control.Furthermore,the paper examines the future developmental directions of M.alternifolia essential oil in pest control,along with the current challenges associated with its application.The aim is to offer insights for future research on botanical essential oils,particularly regarding their biological functions and applications in agricultural pest control. 展开更多
关键词 Melaleuca alternifolia Environmentally friendly Essential oil Biological function Agricultural pest control
暂未订购 下载PDF
The biological functions of protein lactylation 认领 引用
3
作者 CHEN Jia-Qi HE Yue-Jing +6 位作者 ZHENG Hui-Ling YUAN Yuan JIANG Zhi-Wen CHEN Jia-Jin ZHENG Xin-Yi LIU Xin-Guang SUN Xue-Rong 《生理学报》 CAS CSCD 北大核心 2025年第6期1035-1046,共12页
Lactylation is one of the post-translational modifications of proteins,a process in which lactyl residues bind to the lysine residues of proteins.This modification can alter the structure,stability,and function of pro... Lactylation is one of the post-translational modifications of proteins,a process in which lactyl residues bind to the lysine residues of proteins.This modification can alter the structure,stability,and function of proteins,which in turn regulates cellular metabolism,aging,and the onset of disease.This review classifies proteins with lactylation effects into histones and non-histone proteins and analyzes their functional roles when lactylation occurs.The in-depth exploration of lactylation is still in its infancy,and many aspects of its regulation,functional significance and therapeutic potential need to be further explored. 展开更多
关键词 lactylation post-translational modifications biological function histones non-histone proteins
暂未订购 下载PDF
Biological function of resveratrol and its application in animal production:a review 认领 引用 被引量：24
4
作者 Qingwei Meng Jiawei Li +1 位作者 Chunsheng Wang Anshan Shan 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2023年第3期864-886,共23页
With the prohibition of antibiotics in feed,plant functional substances have been widely studied as feed additives.Resveratrol,a natural stilbene,and a non-flavonoid polyphenol found in plants,possesses antioxidant,an... With the prohibition of antibiotics in feed,plant functional substances have been widely studied as feed additives.Resveratrol,a natural stilbene,and a non-flavonoid polyphenol found in plants,possesses antioxidant,anti-inflammatory,and metabolic regulatory features.Resveratrol generated intense scientific and public interest,primarily due to its widely reported ability to prevent cancer,delay aging and alleviate related metabolic diseases.Recently,resveratrol has been studied and applied as a feed additive in animal production.This review focuses on the outline of the absorption and metabolism and biological functions of resveratrol and summarizes the application of dietary resveratrol in animal production up to the present,including pigs,poultry,and ruminants.In pigs,dietary resveratrol improved intestinal health,mitochondrial function,meat quality,and more.In poultry,studies have shown that dietary resveratrol improves growth performance and meat and egg quality and alleviates heat stress induced adverse effects.There are few studies on dietary resveratrol in ruminants;however previous studies have indicated that dietary resveratrol increases nutrient digestibility and reduces methane emissions in sheep.It is hoped that this review could provide a specific theoretical basis and research ideas for the research and application of resveratrol. 展开更多
关键词 Animal production Biological function Health Pigs Poultry Resveratrol Ruminants
暂未订购 下载PDF
Chemical constituents,biological functions and pharmacological effects for comprehensive utilization of Eucommia ulmoides Oliver 认领 引用 被引量：37
5
作者 Yi-Fan Xing Dong He +6 位作者 Yi Wang Wen Zeng Chong Zhang Yuan Lu Nan Su Yan-Hua Kong Xin-Hui Xing 《Food Science and Human Wellness》 SCIE CAS 2019年第2期177-188,共12页
Eucommia ulmoides Oliver is a native plant and valuable tonic Chinese medicine in China with a long history,great economic value and comprehensive development potential.Traditionally,the comprehensive utilization rate... Eucommia ulmoides Oliver is a native plant and valuable tonic Chinese medicine in China with a long history,great economic value and comprehensive development potential.Traditionally,the comprehensive utilization rate of E.ulmoides Oliv.is still very low,only bark has been used as medicine and other parts of Eucommia ulmoides Oliv.cannot be fully utilized,even the leaves have been well utilized in food products in Japan in the past decades.In order to improve the comprehensive utilization efficiency of E.ulmoides Oliv.,in this review,we summarized the varieties and contents of main active compounds,biological functions and pharmacological effects in different parts of E.ulmoides Oliv.The findings suggest that other parts of E.ulmoides Oliv.could replace the bark of E.ulmoides Oliv.to some extent besides of their respective applications.The unique and extensive physiological functions between different parts of E.ulmoides Oliv.indicate that the comprehensive utilization of E.ulmoides Oliv.has a wide space to develop,which is also an effective way to protect E.ulmoides Oliv.resources and improve its the utilization rate. 展开更多
关键词 Eucommia ulmoides Oliver Comprehensive utilization Chemical constituents Biological functions Pharmacological effects
暂未订购 下载PDF
MiR-19a-3p regulates the Forkhead box F2-mediated Wnt/β-catenin signaling pathway and affects the biological functions of colorectal cancer cells 认领 引用 被引量：13
6
作者 Fu-Bing Yu Juan Sheng +3 位作者 Jia-Man Yu Jing-Hua Liu Xiang-Xin Qin Bo Mou 《World Journal of Gastroenterology》 SCIE CAS 2020年第6期627-644,共18页
BACKGROUND Colorectal cancer(CRC)is one of the most common malignancies worldwide.AIM To explore the expression of microRNA miR-19a-3p and Forkhead box F2(FOXF2)in patients with CRC and the relevant mechanisms.METHODS... BACKGROUND Colorectal cancer(CRC)is one of the most common malignancies worldwide.AIM To explore the expression of microRNA miR-19a-3p and Forkhead box F2(FOXF2)in patients with CRC and the relevant mechanisms.METHODS Sixty-two CRC patients admitted to the hospital were enrolled into the study group,and sixty healthy people from the same period were assigned to the control group.Elbow venous blood was sampled from the patients and healthy individuals,and blood serum was saved for later analysis.MiR-19a-3p mimics,miR-19a-3p inhibitor,miR-negative control,small interfering-FOXF2,and short hairpin-FOXF2 were transfected into HT29 and HCT116 cells.Then quantitative polymerase chain reaction was performed to quantify the expression of miR-19a-3p and FOXF2 in HT29 and HCT116 cells,and western blot(WB)analysis was conducted to evaluate the levels of FOXF2,glycogen synthase kinase 3 beta(GSK-3β),phosphorylated GSK-3β(p-GSK-3β),β-catenin,p-β-catenin,α-catenin,Ncadherin,E-cadherin,and vimentin.The MTT,Transwell,and wound healing assays were applied to analyze cell proliferation,invasion,and migration,respectively,and the dual luciferase reporter assay was used to determine the correlation of miR-19a-3p with FOXF2.RESULTS The patients showed high serum levels of miR-19a-3p and low levels of FOXF2,and the area under the curves of miR-19a-3p and FOXF2 were larger than 0.8.MiR-19a-3p and FOXF2 were related to sex,tumor size,age,tumor-nodemetastasis staging,lymph node metastasis,and differentiation of CRC patients.Silencing of miR-19a-3p and overexpression of FOXF2 suppressed the epithelialmesenchymal transition,invasion,migration,and proliferation of cells.WB analysis revealed that silencing of miR-19a-3p and FOXF2 overexpression significantly suppressed the expression of p-GSK-3β,β-catenin,N-cadherin,and vimentin;and increased the levels of GSK-3β,p-β-catenin,α-catenin,and Ecadherin.The dual luciferase reporter assay confirmed that there was a targeted correlation of miR-19a-3p with FOXF2.In addition,a rescue experiment revealed that there were no differences in cell proliferation,invasion,and migration in HT29 and HCT116 cells co-transfected with miR-19a-3p-mimics+sh-FOXF2 and miR-19a-3p-inhibitor+si-FOXF2 compared to the miR-negative control group.CONCLUSION Inhibiting miR-19a-3p expression can upregulate the FOXF2-mediated Wnt/β-catenin signaling pathway,thereby affecting the epithelial-mesenchymal transition,proliferation,invasion,and migration of cells.Thus,miR-19a-3p is likely to be a therapeutic target in CRC. 展开更多
关键词 MiR-19a-3p Forkhead box F2 Wnt/β-catenin signaling pathway Biological function Colorectal cancer Western blot
暂未订购 下载PDF
The biological functions and metabolic pathways of valine in swine 认领 引用 被引量：5
7
作者 Chuni Wang Yao Peng +4 位作者 Yiru Zhang Juan Xu Sheng Jiang Leli Wang Yulong Yin 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第1期20-34,共15页
Valine is an essential amino acid and a type of branched-chain amino acid. Due to the involvement of branchedchain amino acids in various metabolic pathways, there has been a surge of interests in valine nutrition and... Valine is an essential amino acid and a type of branched-chain amino acid. Due to the involvement of branchedchain amino acids in various metabolic pathways, there has been a surge of interests in valine nutrition and its role in animal physiology. In pigs, the interactions between valine and other branched-chain amino acids or aromatic amino acids are complex. In this review, we delve into the interaction mechanism, metabolic pathways, and biological functions of valine. Appropriate valine supplementation not only enhances growth and reproductive performances, but also modulates gut microbiota and immune functions. Based on past observations and interpretations, we provide recommended feed levels of valine for weaned piglets, growing pigs, gilts, lactating sows, barrows and entire males. The summarized valine nutrient requirements for pigs at different stages offer valuable insights for future research and practical applications in animal husbandry. 展开更多
关键词 Additional dosage Biological function Metabolic pathway Pig Valine
暂未订购 下载PDF
The biological function of type I receptors of bone morphogenetic protein in bone 认领 引用 被引量：11
8
作者 Shuxian Lin Kathy KH Svoboda +1 位作者 Jian Q Feng Xinquan Jiang 《Bone Research》 SCIE CAS CSCD 2016年第2期63-71,共9页
Bone morphogenetic proteins （BMPs） have multiple roles in skeletal development, homeostasis and regeneration. BMPs signal via type I and type II serinehreonine kinase receptors （BMPRI and BMPRII）. In recent decade... Bone morphogenetic proteins （BMPs） have multiple roles in skeletal development, homeostasis and regeneration. BMPs signal via type I and type II serinehreonine kinase receptors （BMPRI and BMPRII）. In recent decades, genetic studies in humans and mice have demonstrated that perturbations in BMP signaling via BMPRI resulted in various diseases in bone, cartilage, and muscles. In this review, we focus on all three types of BMPRI, which consist of activin-like kinase 2 （ALK2, also called type IA activin receptor）, activin- llke kinase 3 （ALK3, also called BMPRIA）, and activin-like kinase 6 （ALK6, also called BMPRIB）. The research areas covered include the current progress regarding the roles of these receptors during myogenesis, chondrogenesis, and osteogenesis. Understanding the physiological and pathological functions of these receptors at the cellular and molecular levels will advance drug development and tissue regeneration for treating musculoskeletal diseases and bone defects in the future. 展开更多
关键词 ALK The biological function of type I receptors of bone morphogenetic protein in bone type
暂未订购 下载PDF
Na+/K+-ATPase:ion pump,signal transducer,or cytoprotective protein,and novel biological functions 认领 引用 被引量：4
9
作者 Songqiang Huang Wanting Dong +1 位作者 Xiaoqian Lin Jinsong Bian 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第12期2684-2697,共14页
Na+/K+-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na+out of and two K+into cells.Additionally,Na^... Na+/K+-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na+out of and two K+into cells.Additionally,Na+/K+-ATPase participates in Ca2+-signaling transduction and neurotransmitter release by coordinating the ion concentration gradient across the cell membrane.Na+/K+-ATPase works synergistically with multiple ion channels in the cell membrane to form a dynamic network of ion homeostatic regulation and affects cellular communication by regulating chemical signals and the ion balance among different types of cells.Therefo re,it is not surprising that Na+/K+-ATPase dysfunction has emerged as a risk factor for a variety of neurological diseases.However,published studies have so far only elucidated the important roles of Na+/K+-ATPase dysfunction in disease development,and we are lacking detailed mechanisms to clarify how Na+/K+-ATPase affects cell function.Our recent studies revealed that membrane loss of Na+/K+-ATPase is a key mechanism in many neurological disorders,particularly stroke and Parkinson's disease.Stabilization of plasma membrane Na+/K+-ATPase with an antibody is a novel strategy to treat these diseases.For this reason,Na+/K+-ATPase acts not only as a simple ion pump but also as a sensoregulator or cytoprotective protein,participating in signal transduction such as neuronal autophagy and apoptosis,and glial cell migration.Thus,the present review attempts to summarize the novel biological functions of Na+/K+-ATPase and Na+/K+-ATPase-related pathogenesis.The potential for novel strategies to treat Na+/K+-ATPase-related brain diseases will also be discussed. 展开更多
关键词 antibody biological functions cellular communication electrochemical gradient ion balance ion channels Na+/K+-ATPase neurological diseases neurotransmitter release signal transduction
暂未订购 下载PDF
Biological Function of REE in Plants&Microbes 认领 引用 被引量：2
10
作者 Qiu Guanming Li Wei +1 位作者 Li Xikun Zhou Wei 《Journal of Rare Earths》 SCIE EI CAS 2005年第6期645-652,共8页
Rare earth elements(REE)and their compounds years.The bioinorganic chemical research of REE during the are widely applied in agronomic and medical fields for many past few years indicates that REE play important roles... Rare earth elements(REE)and their compounds years.The bioinorganic chemical research of REE during the are widely applied in agronomic and medical fields for many past few years indicates that REE play important roles in the promotion of photosynthetic rate as well as root absorption,regulation of hormone and nitrogen metabolism,and suppression of microbes,etc.The metallic or non-metallic targets of key biomolecule in various physiological processes can be chosen by REE for the chelation or replacement,which enables REE to regulate the biological functions or behaviors of those biomolecule and consequently leads to significant embodiment of biological function of REE in plants and microbes.Overdose of REE,however,shows an inhibitory effect on living organisms.Therefore,this paper proposes two suggestions that will be available in the extension of full use of REE's biological function.One is to obey the dose law of REE and control REE concentrations within a safe range.The other is to further test the bioaccumulation and long-period influence of REE on organisms. 展开更多
关键词 bioinorganic chemistry biological function of REE plants and microbes dosage effect bioaccumulation rare earths
暂未订购 下载PDF
Over-expression of LRIG1 Suppresses Biological Function of Pituitary Adenoma via Attenuation of PI3K/AKT and Ras/Raf/ERK Pathways In Vivo and In Vitro 认领 引用 被引量：4
11
作者 程世奇 范恒怡 +8 位作者 徐新 高伟伟 吕世刚 叶敏华 吴淼经 沈晓黎 程祖珏 祝新根 张焱 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 2016年第4期558-563,共6页
Pituitary adenomas（PAs） are well known as a common intracranial benign tumor, and a portion of PAs are refractory to current therapeutic methods. Erb B receptors family signaling pathway regulates the expression of ... Pituitary adenomas（PAs） are well known as a common intracranial benign tumor, and a portion of PAs are refractory to current therapeutic methods. Erb B receptors family signaling pathway regulates the expression of PAs activation associated gene. Inhibition of epidermal growth factor receptor（EGFR） can inhibit proliferation of PAs. Leucine-rich repeats and immunoglobulin-like domains protein 1（ LRIG1）, a negative mediated gene of Erb B receptors family, plays a role in many tumors. However, there are seldom researches about the functional role of LRIG1 in PAs. The aim of this study is to explore the potential effect of LRIG1 and its regulating mechanism in PAs. First, we investigated the role of LRIG1 in cell migration, invasion of PAs with transfected LRIG1 or control. Then, we explored its impact on cell proliferation and apoptosis of PAs in vivo. To study the regulating mechanism of LRIG1, we examined the expression of molecular factor of PI3K/AKT and Ras/Raf/ERK pathway using Western blotting in vitro and RT-PCR in vitro and in vivo. It was found that LRIG1 over-expression inhibited cell migration, invasion and proliferation, and promoted apoptosis of PAs in vivo and in vitro. Furthermore, LRIG1 suppressed the expression of signaling of PI3K/AKT and Ras/Raf/ERK pathways in PAs. LRIG1, as a negative mediated gene of tumor, can inhibit biological function of PAs via inhibiting PI3K/AKT and Ras/Raf/ERK pathways, and it might be a new target for gene therapy of PAs. 展开更多
关键词 LRIG1 pituitary adenoma biological function
暂未订购 下载PDF
Effect of microRNA-143-3p-mediated CTNND1 on the biological function of lung cancer cells 认领 引用
12
作者 Xinxiong FEI Wenbin HU +3 位作者 Gangsheng WANG Chunyan SU Xuqun HUANG Zhongjun JIANG 《BIOCELL》 SCIE 2020年第1期81-88,共8页
Lung cancer poses a serious threat to human life with high incidence and miRNA is an important biomarkerin tumors. This study aimed to explore the effect of miR-143-3p on the biological function of lung cancer cells a... Lung cancer poses a serious threat to human life with high incidence and miRNA is an important biomarkerin tumors. This study aimed to explore the effect of miR-143-3p on the biological function of lung cancer cells and theunderlying mechanism. Eighty-seven samples of lung cancer tissues and 81 samples of tumor-adjacent tissues from patients undergoing radical lung cancer surgery in our hospital were collected. The lung cancer cells and lung fibroblastcells (HFL-1) were purchased, and then miR-143-3p-mimics, miR-NC, si-CTNND1, and NC were transfected into A549 and PC-9 cells to establish cell models. MiR-143-3p and CTNND1 expression levels were measured by the qRT-PCR, Bax, Bcl-2, and CTNND1 expression levels by the Western Blot (WB), and cell proliferation, invasion, and apoptosis by the MTT assay, Transwell assay, and flow cytometry. Dual luciferase report assay was used to determinethe relationship between miR-143-3p and CTNND1. In this study, miR-143-3p was lowly expressed in lung cancer and CTNND1 was highly expressed in lung cancer. The overexpression of miR-143-3p inhibited cell proliferation and invasion, promoted cell apoptosis, significantly increased Bax protein expression, and decreased Bcl-2 protein expression. The inhibition of CTNND1 led to opposite biological characteristic in cells. The dual luciferase reporter assay demonstrated that miR-143-3p was a target region of CTNND1. Such results suggest that miR-143-3p can inhibitthe proliferation and invasion of lung cancer cells by regulating the expression of CTNND1 and promote the apoptosisof lung cancer cells, sott is expected to be a potential target for lung cancer. 展开更多
关键词 Biological function CTNND1 Lung cancer MiR-143-3p
暂未订购 下载PDF
Biological Function Research Progress of FABP5 认领 引用
13
作者 Li Meng Gao Xue-jun 《Journal of Northeast Agricultural University(English Edition)》 CAS 2017年第1期92-96,共5页
The intracellular Fatty Acid Binding Proteins （FABPs） are a well-conserved family which functions as lipid chaperones. Recent findings also reveal that they are crucial mediators of lipid metabolism, cell growth and... The intracellular Fatty Acid Binding Proteins （FABPs） are a well-conserved family which functions as lipid chaperones. Recent findings also reveal that they are crucial mediators of lipid metabolism, cell growth and differentiation, cellular signaling and gene transcription. Ongoing studies are identifying the mechanistic complexity and vast biological diversity of different isoforms of FABPs. This paper introduced the biological function of FABP5 in inflammatory, metabolic diseases and milk fat synthesis. 展开更多
关键词 FABP5 biological function PPARβ/δ milk fat synthesis
暂未订购 下载PDF
Stochastic thermodynamics for biological functions 认领 引用 被引量：1
14
作者 Yuansheng Cao Shiling Liang 《Quantitative Biology》 CAS CSCD 2025年第1期29-47,共19页
Living systems operate within physical constraints imposed by nonequilibrium thermodynamics.This review explores recent advancements in applying these principles to understand the fundamental limits of biological func... Living systems operate within physical constraints imposed by nonequilibrium thermodynamics.This review explores recent advancements in applying these principles to understand the fundamental limits of biological functions.We introduce the framework of stochastic thermodynamics and its recent developments,followed by its application to various biological systems.We emphasize the interconnectedness of kinetics and energetics within this framework,focusing on how network topology,kinetics,and energetics influence functions in thermodynamically consistent models.We discuss examples in the areas of molecular machine,error correction,biological sensing,and collective behaviors.This review aims to bridge physics and biology by fostering a quantitative understanding of biological functions. 展开更多
关键词 biological functions physical constraints stochastic thermodynamics
Unraveling the complex regulatory network of DHN melanin biosynthesis and biological functions in phytopathogenic fungi 认领 引用
15
作者 Rong Li Yongcai Li Yang Bi 《Phytopathology Research》 SCIE CAS CSCD 2025年第1期1203-1219,共17页
DHN(1,8-dihydroxynaphthalene)melanin is a significant secondary metabolite found in phytopathogenic fungi,predominantly localized in mature aerial hyphae,conidia,and appressoria.It performs various biological function... DHN(1,8-dihydroxynaphthalene)melanin is a significant secondary metabolite found in phytopathogenic fungi,predominantly localized in mature aerial hyphae,conidia,and appressoria.It performs various biological functions,including responding to extreme environments and regulating growth,development,and pathogenicity.Key biosynthetic enzymes and transcription factors directly involved in the DHN melanin synthesis pathway include melanin synthesis transcription factors,polyketide synthase,1,3,6,8-tetrahydroxynaphthalene reductase,scytalone dehydratase,1,3,8-trihydroxynaphthalene reductase,and a-hydrolase.The regulatory network controlling the DHN melanin biosynthesis is complex and multifaceted,involving various transcription factors,signaling pathways,and metabolic routes.This review provides a comprehensive summary of current research on the abundant biological functions of DHN melanin.Understanding the molecular mechanisms of DHN melanin synthesis in phytopathogenic fungi could facilitate the development of effective disease control strategies and novel therapeutic targets. 展开更多
关键词 DHN melanin Phytopathogenic fungi Regulatory mechanisms Biological functions
Sequencing analysis of bovine milk exosomal miRNA and the effect of Bta-miR-141 on the biological function of HepG2 cells 认领 引用 被引量：2
16
作者 Hong Yu Jingwen Shang +3 位作者 Chunshuang Wu Xue Bai Xinping Chen Mei Yang 《Food Bioscience》 SCIE 2025年第2期1566-1575,共10页
Significant progress has been made in establishing the roles of microRNAs(miRNAs)in cancer.Liver cancer has high morbidity and mortality,and bovine milk is the most consumed dairy product and is a source of miRNA exos... Significant progress has been made in establishing the roles of microRNAs(miRNAs)in cancer.Liver cancer has high morbidity and mortality,and bovine milk is the most consumed dairy product and is a source of miRNA exosomes.We therefore,examined the effect of miRNAs in bovine milk exosomes on the function of hepato-cellular carcinoma cells.We performed sequencing of bovine milk exosomal RNA to identify miRNAs.We then performed miRNA target gene prediction and bioinformatic analysis,which identified bta-miR-141 and its target gene,TGFBR2,to be relevant to liver cancer.We examined the expression levels of bta-miR-141 and TGFBR2 by reverse transcription quantitative polymerase chain reaction.The effects of bta-miR-141 on the proliferation,invasion,migration,and clone formation of HepG2 cells were examined by CCK-8,Transwell invasion,scratch,and cell cloning assays,respectively.Overexpression of bta-miR-141 decreased the proliferation,invasion,migration,and clonogenic ability of HepG2 cells.Therefore,bta-miR-141 has a functional role in HepG2 cells and overexpression of bta-miR-141 may alleviate the deterioration of HepG2 cells.This study provides new infor-mation concerning miRNAs for the development of functional milk powders. 展开更多
关键词 Bovine milk exosomes Bta-miR-141 HepG2 cells Biological function
Chemical reactions in living cells for enhanced biological treatment 认领 引用 被引量：1
17
作者 Yunfei Fu Hui Li +1 位作者 Chengfei Liu Wei Tian 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第4期82-91,共10页
Inspired by the natural synthesis of biomolecules,the artificial production of therapeutic agents within cells has emerged as a powerful and versatile approach for disease treatment.Performing artificial chemical reac... Inspired by the natural synthesis of biomolecules,the artificial production of therapeutic agents within cells has emerged as a powerful and versatile approach for disease treatment.Performing artificial chemical reactions within living cells to achieve various physiological goals remains both an intriguing and highly challenging endeavor.This review summarizes recent advancements and future trends in the field of chemical reactions inside living cells,organized by different reaction mechanisms.We also provide an in-depth discussion of their chemical designs,reaction mechanisms,and functional applications.Furthermore,we explore the underlying chemical principles of these reactions and discuss strategies for these materials to enhance their therapeutic efficacy.As researchers continue to expand the repertoire of intracellular synthesis techniques,it is anticipated that these advancements will provide valuable tools for probing biological systems and developing innovative therapeutic strategies. 展开更多
关键词 Intracellular reaction Supramolecular chemistry Intracellular self-assembly Biological functions
暂未订购 下载PDF
ZnO-SnO2/WO3-x heterojunction artificial synapse for realization and integration of multiple biological cognitive functions 认领 引用 被引量：1
18
作者 Pengfei Sun Ruidong Li +3 位作者 Haotian Meng Tao Sun Song Gao Yang Li 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2025年第5期433-445,共13页
In current memristor-based neuromorphic computing research,several studies face the challenge of realizing only a single function at a time or having isolated functions.This limitation is particularly evident when sim... In current memristor-based neuromorphic computing research,several studies face the challenge of realizing only a single function at a time or having isolated functions.This limitation is particularly evident when simulating biological cognition,as the overall synergy between multiple cognitive functions is difficult to represent.In this work,a high-performance heterojunction memristor is presented at first.The memristor-based neural network and functional circuit are further implemented to realize and integrate multiple cognitive functions.Specifically,the proposed photoelectric memristor has the structure of Ag/ZnO-SnO2/WO3-x/ITO,it exhibits various synaptic behaviors under external modulations,which are characterized by good stability and repeatability.Based on this device,a neural network is built to realize the basic recognition function in biological cognition.The recognition results are translated into different labelled voltage signals and subsequently fed into a memristor-based functional circuit.By leveraging memory characteristics and tunable conductance of the memristor,and controlling the specific circuit functionalities,the input signals are processed to produce different outputs representing various cognitive functions.This methodology allows the realization and integration of recognition,memory,learning,association,relearning,and forgetting into one single system,thereby enabling a more comprehensive and authentic simulation of biological cognition.This work presents a novel memristor and a method for achieving and integrating multiple neuromorphic computing functions within a single system,providing a successful example for achieving complete biological function. 展开更多
关键词 optoelectronicdevice oxide heterojunction memristor neuromorphic computing multiple biological cognitive functions low-power consumption system
暂未订购 下载PDF
Autophagy and beyond:Unraveling the complexity of UNC-51-like kinase 1(ULK1)from biological functions to therapeutic implications 认领 引用 被引量：21
19
作者 Ling Zou Minru Liao +5 位作者 Yongqi Zhen Shiou Zhu Xiya Chen Jin Zhang Yue Hao Bo Liu 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2022年第10期3743-3782,共40页
UNC-51-like kinase 1(ULK1),as a serinehreonine kinase,is an autophagic initiator in mammals and a homologous protein of autophagy related protein(Atg)1 in yeast and of UNC-51 in Caenorhabditis elegans.ULK1 is well-kno... UNC-51-like kinase 1(ULK1),as a serinehreonine kinase,is an autophagic initiator in mammals and a homologous protein of autophagy related protein(Atg)1 in yeast and of UNC-51 in Caenorhabditis elegans.ULK1 is well-known for autophagy activation,which is evolutionarily conserved in protein transport and indispensable to maintain cell homeostasis.As the direct target of energy and nutrition-sensing kinase,ULK1 may contribute to the distribution and utilization of cellular resources in response to metabolism and is closely associated with multiple pathophysiological processes.Moreover,ULK1 has been widely reported to play a crucial role in human diseases,including cancer,neurodegenerative diseases,cardiovascular disease,and infections,and subsequently targeted small-molecule inhibitors or activators are also demonstrated.Interestingly,the non-autophagy function of ULK1 has been emerging,indicating that non-autophagy-relevant ULK1 signaling network is also linked with diseases under some specific contexts.Therefore,in this review,we summarized the structure and functions of ULK1 as an autophagic initiator,with a focus on some new approaches,and further elucidated the key roles of ULK1 in autophagy and non-autophagy.Additionally,we also discussed the relationships between ULK1 and human diseases,as well as illustrated a rapid progress for better understanding of the discovery of more candidate small-molecule drugs targeting ULK1,which will provide a clue on novel ULK1-targeted therapeutics in the future. 展开更多
关键词 UNC-51-like kinase 1(ULK1) Autophagy Non-autophagy Biological function Small-molecule drug ULK1-targeted therapy Human diseases
暂未订购 下载PDF
Classification,biosynthesis,and biological functions of triterpene esters in plants 认领 引用 被引量：7
20
作者 Jia Liu Xue Yin +3 位作者 Chengxi Kou Ramesha Thimmappa Xin Hua Zheyong Xue 《Plant Communications》 SCIE CSCD 2024年第4期67-93,共27页
Triterpene esters comprise a class of secondary metabolites that are synthesized by decorating triterpene skeletons with a series of oxidation,glycosylation,and acylation modifications.Many triterpene esters with impo... Triterpene esters comprise a class of secondary metabolites that are synthesized by decorating triterpene skeletons with a series of oxidation,glycosylation,and acylation modifications.Many triterpene esters with important bioactivities have been isolated and identified,including those with applications in the pesticide,pharmaceutical,and cosmetic industries.They also play essential roles in plant defense against pests,dis-eases,physical damage(as part of the cuticle),and regulation of root microorganisms.However,there has been no recent summary of the biosynthetic pathways and biological functions of plant triterpene esters.Here,we classify triterpene esters intofive categories based on their skeletons andfind that C-3 oxidation may have a significant effect on triterpenoid acylation.Fatty acid and aromatic moieties are common li-gands present in triterpene esters.We further analyze triterpene ester synthesis-related acyltransferases(TEsACTs)in the triterpene biosynthetic pathway.Using an evolutionary classification of BAHD acyltrans-ferases(BAHD-ATs)and serine carboxypeptidase-like acyltransferases(SCPL-ATs)in Arabidopsis thaliana and Oryza sativa,we classify 18 TEsACTs with identified functions from 11 species.All the triterpene-skel-eton-related TEsACTs belong to BAHD-AT clades IIIa and I,and the only identified TEsACT from the SCPL-AT family belongs to the CP-I subfamily.This comprehensive review of the biosynthetic pathways and bioactivities of triterpene esters provides a foundation for further study of their bioactivities and applica-tions in industry,agricultural production,and human health. 展开更多
关键词 triterpene esters acyltransferases classification biosynthesis biological functions
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 … 5 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈