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The evolving burden of heart failure in China:a 34-year subnational analysis of trends and causes from the Global Burden of Disease Study 2023 认领 引用 被引量：8
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作者 Xuan Yang Zhen-Ping Zhao +4 位作者 Yu Shi Gui-Yuan Han Yan Xu Yi-Chong Li Mai-Geng Zhou 《Military Medical Research》 SCIE CAS CSCD 2026年第3期413-425,共13页
Background:Heart failure(HF)continues to be a public health issue in China with population aging and increasing disease drivers.The burden,spatial patterns,temporal trends,and underlying causes of HF in China at subna... Background:Heart failure(HF)continues to be a public health issue in China with population aging and increasing disease drivers.The burden,spatial patterns,temporal trends,and underlying causes of HF in China at subnational levels remain inadequately understood.This study aims to assess the disease burden and causes of HF,and their regional disparities in China from 1990 to 2023.Methods:Utilizing the estimates from the Global Burden of Diseases,Injuries,and Risk Factors Study(GBD)2023,we assessed the prevalence and years lived with disability(YLDs)of HF and their trends in China at both national and subnational levels.Estimates were also compared by disease severity,sex,age group,cause,and region.Results:In 2023,China had an estimated 14.3 million HF cases,marking a significant 208.4% increase over the past three decades.Ischemic heart disease(IHD)has become the top cause of HF,compared with 1990,with hypertensive heart disease(HHD)at the top.Alongside chronic obstructive pulmonary disease(COPD),these three leading causes accounted for 77.4%of all HF cases.The burden of HF due to IHD and COPD exhibited distinct regional patterns and substantial disparities:regions in northern China exhibited notably higher age-standardized YLDs rates for HF due to IHD,while provinces in the western regions faced the highest burden from COPD.Six provinces with the highest tertile of YLDs rates in 2023 also experienced the most pronounced increases between 1990 and 2023.Conclusions:HF remains a significant public health challenge in China,with a marked increase in prevalence over the past three decades.The substantial regional variations highlight the need for targeted and region-specific public health strategies.Enhanced nationwide efforts should be made to reduce the geographical disparities in the burden of HF. 展开更多
关键词 Heart failure(HF) China Global Burden of Diseases Epidemiology
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Global, regional, and national burden of ischemic heart disease attributable to metabolic risks: a systematic analysis of Global Burden of Disease 2021 认领 引用 被引量：1
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作者 Bo-Qing LIU Chang YANG +1 位作者 Heng-Yang WEI Zai-Xin YU 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2025年第3期361-380,共20页
Background Ischemic heart disease(IHD) represents the most significant disease burden among all cardiovascular diseases(CVDs). The increasing prevalence of metabolic risks in the 21st century has a profound impact on ... Background Ischemic heart disease(IHD) represents the most significant disease burden among all cardiovascular diseases(CVDs). The increasing prevalence of metabolic risks in the 21st century has a profound impact on the disease burden associated with IHD. We analyzed the global, regional, and national burdens of IHD attributable to metabolic risks from 1990 to 2021.Methods The data were taken from Global Burden of Disease(GBD) study 2021. Deaths, disability-adjusted life years(DALYs),the average annual percent change(AAPC), age-standardized death rates per 100,000 persons(ASDR) and age-standardized rate per 100,000 persons(ASR) of DALYs ranging from 1990 to 2021, were extracted and stratified according to region, nationality, socio-demographic index(SDI), sex, and age. Additionally, the global future trends were predicted using Nordpred prediction model.Results Compared to 1990, in 2021, the number of death and DALYs from metabolic risk-attributed IHD increased globally by67.35% and 59.91%, respectively;whereas ASDR and ASR of DALYs showed a decreasing trend and the most severe impact was observed in male and elderly populations. In addition, the burden of disease showed an inverted V-shaped relationship with SDI from 1990 to 2021. AAPC showed a significant increase in developing countries and a decrease in developed countries. We also analyzed the effects of different risk factors including metabolic risk factors on IHD in different SDI regions and genders. The prediction of future disease burden showed that the number of death and DALYs will keep rising, while ASDR and ASR of DALYs will maintain a certain downward trend.Conclusions The results of this study highlighted the need for screening and intervention for metabolic risk factors in specific regions and populations, this should call for increased collaboration between developing and developed countries to reduce the burden of disease and improve the prognosis of patients with IHD. 展开更多
关键词 burden global burden cardiovascular diseases cvds global burden disease study ischemic heart disease ischemic heart disease ihd metabolic risks national burden
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National mortality burden attributable to the unprecedented heatwave in 2022 in China 认领 引用
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作者 Jian-Xiong Hu Yu-Lin Zhuo +14 位作者 Guan-Hao He Jiang-Mei Liu Yan-Fang Guo Tian-Tian Li Wei-Wei Gong Fang-Fang Zeng Hai-Lai Duan Rui-Lin Meng Chun-Liang Zhou Yi-Ze Xiao Min Yu Biao Huang Mai-Geng Zhou Wen-Jun Ma Tao Liu 《Military Medical Research》 SCIE CAS CSCD 2026年第6期929-943,共15页
Background:In 2022,China experienced an unprecedented heatwave event,raising concerns about the health impacts of heatwaves.This study aims to understand the devastating health risk of the exceptional heatwave in 2022... Background:In 2022,China experienced an unprecedented heatwave event,raising concerns about the health impacts of heatwaves.This study aims to understand the devastating health risk of the exceptional heatwave in 2022 by comparing heatwave-related mortality burden in 2022 with that during 2000-2021.Methods:We collected daily mortality and daily maximum temperature(DMT)during 2006-2017 in 364 locations(counties/districts)of China.Heatwave was defined as an event with 2 or more consecutive days of DMT exceeding the 92.5th percentile.We employed a distributed lag nonlinear model(DLNM)and a meta-analysis to examine the heatwave-mortality association based on the data from 364 counties/districts,and then this association was used to assess the mortality burden attributable to heatwaves during 2000-2022 in 368 cities in China.A percentage change(%)indicator,comparing the 2022 mortality burden to the average value from 2000 to 2021,was further calculated to highlight the severity of heatwaves in 2022.Results:In the past two decades,the frequency and intensity of heatwaves in China significantly increased,with the cumulative excessive degree-day increasing to 31,626 in 2022 compared with the annual average value of 13,772 during 2000-2021 across China.In 2022,we observed 62,961[95%confidence internal(CI)54,945-70,413]heatwave-related deaths in China,which was much higher than the annual average[35,987(95% CI 31,252-40,471)]attributable to heatwaves during 2000-2021.The vulnerability groups of heatwave-related mortality in 2022 primarily included patients with cardiovascular diseases[40,567(95% CI 35,313-45,404)],females[35,876(95%CI 31,035-41,005)],and people aged over 65 years[56,208(95% CI 49,023-62,864)];and greater heatwave-related mortality was found in eastern-central China.The attributable fraction(AF)of heatwave-related deaths increased from an annual average of 11.01‰(95%CI 9.56-12.38)during 2000-2021 to 18.11‰(95% CI 15.80-20.25)in 2022 with 64.43%increment(95% CI 38.10-93.78),and the increase rates were greater in Xizang Autonomous Region(159.77%,95% CI 12.84-477.87)and Sichuan Province(133.64%,95% CI 3.84-416.61).Conclusions:This study indicated that the frequency and intensity of heatwaves significantly increased in the past two decades in China,and the 2022 heatwaves were linked to a substantial mortality burden in China,with significant population and regional heterogeneity.Our findings underscore the need for developing comprehensive heat adaptation plans in the context of rapid aging and ongoing global warming. 展开更多
关键词 Climate change Heatwave Mortality Risk Burden
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Global patterns,temporal trends and socioeconomic inequalities in the burden of breast cancer:a population-based study across 185 countries 认领 引用
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作者 Weijia Kong Hengna Lin +3 位作者 Jie Li Yaxiong Nie Rongshou Zheng Di Liang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第7期1016-1030,共15页
Objective:Breast cancer is the most frequently diagnosed cancer among women worldwide and is a leading cause of cancer-related deaths.Comparative assessments of breast cancer lifetime risks across populations are limi... Objective:Breast cancer is the most frequently diagnosed cancer among women worldwide and is a leading cause of cancer-related deaths.Comparative assessments of breast cancer lifetime risks across populations are limited.This study estimated the global,regional,and national lifetime risks,temporal trends,and socioeconomic inequalities in the burden of breast cancer.Methods:Using incidence and mortality data from GLOBOCAN 2022(185 countries)and United Nations population and all-cause death data,lifetime risks were calculated using the adjusted for multiple primaries(AMP)method,which could adjust for multiple primary cancers,competing risks of other causes death,and life expectancy.Longitudinal data of breast cancer incidence from 2003±2017 were retrieved from the Cancer Incidence in Five Continents(CI5)Plus database.The temporal trends for breast cancer deaths were abstracted from the WHO Mortality Database.The lifetime risk of developing and dying from breast cancer were analyzed by socioeconomic characteristics,20 predefined geographic regions and menopausal status.Results:The overall worldwide lifetime risk of developing and dying from breast cancer was 5.51%(95%CI:5.50%±5.52%)and 1.82%(95%CI:1.82%±1.83%)in 2022,respectively.The estimated lifetime risks of developing breast cancer had a positive relationship with Human Development Index(HDI)levels and corresponding risks of 10.37%,4.42%,2.96%,and 2.91%in very high,high,middle,and low HDI regions,respectively.Very high HDI regions presented the highest lifetime risk of breast cancer death(2.70%),followed by low HDI(1.70%),medium HDI(1.54%),and high(1.38%)HDI regions.A significant correlation was identified between lifetime risks and health economics capacity.The lifetime risk of developing and dying from breast cancer primarily involved individuals≥55 years of age with remaining risks of 3.77%(developing)and 1.43%(dying)from 55 years to death.The proportion of lifetime risks among individuals 0±44 years of age was higher in Africa regions compared to other regions.In surveillance data from 36 countries,a significant increasing trend in the average annual percentage change(AAPC)was noted in 32 countries,which ranged from 0.17%in the United States to 5.84%in the Republic of Korea.Conclusions:Globally,an estimated 1 in 18 individuals were diagnosed with breast cancer during their lifetime and approximately 1 in 55 died from the disease in 2022.Lifetime risk of breast cancer disparities reveal the socioeconomic inequalities of breast cancer.Therefore,country-tailored intervention plans for breast cancer require prioritization within precision prevention to mitigate global breast cancer inequities and burden. 展开更多
关键词 Breast cancer lifetime risk disease burden incidence mortality
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Expert consensus on the detection and clinical application of tumor mutational burden 认领 引用
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作者 Zhenying Guo Chunwei Xu +168 位作者 Shirong Zhang Yue Hao Xiaotong Hu Ming Zhao Chan Xiang Yingshi Piao Pingli Sun Xueping Xiang Jing Zhao Huanwen Wu Weixing Li Jinpu Yu Jingping Yuan Shuangshuang Wang Cong Wang Yun Gu Bingjian Lv Liping Zhang Yueping Liu Xiaobin Cui Weizhong Gu Yining Li Wei Wang Wenjun Yang Weiguo Long Jingjing Xiang Hong Mou Biao Liu Huajuan Ruan Yubin Wang Yongjie Zhu Feng Wang Zhonghua Wang Xiaomin Feng Xing Liu Peng Li Min Deng Bin Lian Lili Mao Qian Wang Wenxian Wang Zhengbo Song Ziming Li Wenzhao Zhong Zhijie Wang Shengxiang Ren Wenfeng Fang Yongchang Zhang Jingjing Liu Xiuyu Cai Anwen Liu Wen Li Ping Zhan Hongbing Liu Tangfeng Lv Liyun Miao Lingfeng Min Yu Chen Yu Zhang Feng Wang Zhansheng Jiang Gen Lin Long Huang Xingxiang Pu Rongbo Lin Weifeng Liu Chuangzhou Rao Dongqing Lv Zongyang Yu Peng Shen Xiaoyan Li Chuanhao Tang Chengzhi Zhou Junping Zhang Junli Xue Hui Guo Qian Chu Rui Meng Jingxun Wu Rui Zhang Jin Zhou Zhengfei Zhu Yongheng Li Hong Qiu Fan Xia Yuanyuan Lu Xiaofeng Chen Rui Ge Enyong Dai Yu Han Jian Zhang Yinghua Ji Xianbin Liang Hongmei Zhang Xuelei Ma Xuewen Liu Yu Yao Peng Luo Weiwei Pan Fei Pang Fan Wu Dejian Gu Li Wang Liping Wang Youcai Zhu Li Lin Weiwen Li Xinqing Lin Jing Cai Ling Xu Jisheng Li Xiaodong Jiao Kainan Li Jia Wei Huijing Feng Lin Wang Yingying Du Wang Yao Xuefei Shi Xiaomin Niu Dongmei Yuan Yanwen Yao Yinbin Zhang Binbin Song Wenfeng Li Jianfei Fu Hong Wang Mingxiang Ye Dong Wang Zhaofeng Wang Qing Ji Yuan Fang Qing Wei Zhen Wang Bin Wan Donglai Lv Xiaofeng Li Shengjie Yang Jing Kang Jiatao Zhang Chao Zhang Lin Shi Yina Wang Bihui Li Zhang Zhang Ke Wang Zhefeng Liu Nong Yang Lin Wu Xiaobing Chen Gu Jin Zhongwu Li Miao Li Guansong Wang Jiandong Wang Meiyu Fang Yong Fang Xiaojia Wang Jing Chen Yiping Zhang Xixu Zhu Yi Shen Shenglin Ma Biyun Wang Lu Si Yong Song Yuanzhi Lu Aijun Liu Yuchen Han 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第2期218-246,共29页
As an emerging biomarker,tumor mutational burden(TMB)has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy.Currently,TMB is detected primarily by whole-exome sequencing o... As an emerging biomarker,tumor mutational burden(TMB)has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy.Currently,TMB is detected primarily by whole-exome sequencing or targeted panel sequencing on high-throughput sequencing platforms.However,the lack of uniformity in detection methods,threshold settings,and reporting formats,as well as the significant differences in TMB values among different cancer types,have hindered the standardized application of this biomarker in clinical practice.This consensus focuses on the definition,standardization of detection,clinical significance,and limitations of TMB,and provides consensus recommendations for the clinical application of TMB in real-world practice in China.This consensus is aimed at helping clinicians and laboratory personnel understand the clinical significance and testing standards of TMB,promoting more accurate interpretation of test results,and improving patient care. 展开更多
关键词 Biomarkers tumor mutational burden tumor immunotherapy targeted panel sequencing whole-exome sequencing
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Effects of internal parts on burden distribution and segregation in bell-less top blast furnace 认领 引用
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作者 Wang Zeng Ye-Han Fang +6 位作者 Zuo-Bang Chen De-Sheng Zou Guang-Liang Wang Yun-Peng Si Heng Zhou Tian-Xiang Zhang Ming-Yin Kou 《Journal of Iron and Steel Research International》 SCIE EI CSCD 2026年第4期241-255,共15页
As the key equipment connecting the feeding belt to the top of blast furnace,the structure of the hoppers directly affects the burden distribution in blast furnace throat.Therefore,it is of great significance to explo... As the key equipment connecting the feeding belt to the top of blast furnace,the structure of the hoppers directly affects the burden distribution in blast furnace throat.Therefore,it is of great significance to explore the suitable structure of the hoppers to optimize the burden and gas distribution of the blast furnace and improve the gas utilization rate.A three-dimensional model of a 1:1 bell-less top blast furnace with serial-type hoppers was established based on the discrete element method,which simulates the entire movement process of the burden from the belt to each hopper and then to the throat.The effects of internal components,such as the distributor,guiding cone,and buffer platform,on particle size segregation in the upper hopper,the weighing hopper,and the throat of the blast furnace were investigated.The results indicate that removing the distributor can reduce the burden segregation during the discharge from the weighing hopper.The guiding cone significantly influences the radial particle size distribution within the weighing hopper and its discharge.Eliminating the buffer platform promotes a more uniform burden distribution both in the weighing hopper and the throat of the blast furnace.Among the conditions investigated,removing the distributor and the buffer platform yields the best distribution,with the segregation index improved by 92%compared to the base model,which is recommended for practical operations. 展开更多
关键词 Blast furnace Burden distribution Segregation Internal part Discrete element method
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Global burden,risk factors and projections of self-harm mortality in adults aged 65+years:A 60-year trend analysis from the Global Burden of Disease Study 2021 认领 引用
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作者 Jinjie Xu Yiman Guo +3 位作者 Zizhao Feng Meiti Wang Chengwei Guo Yuan Feng 《General Psychiatry》 CAS CSCD 2026年第2期83-92,共10页
Background Epidemiological research on self-harm in older adults(aged 65+years)remains scarce despite its growing public health significance amid global ageing.Aims This study aimed to analyse the global burden,risk f... Background Epidemiological research on self-harm in older adults(aged 65+years)remains scarce despite its growing public health significance amid global ageing.Aims This study aimed to analyse the global burden,risk factors and projections of self-harm mortality in adults aged 65+years from 1990 to 2050.Methods Utilising data from the Global Burden of Disease Study 2021,this research examined the spatiotemporal patterns of self-harm mortality and years of life lost by age,gender and socio-demographic index(SDI)in adults aged 65+across 204 countries and territories(grouped into 21 regions)from 1990 to 2021.It also explored the changes during the coronavirus disease 2019 pandemic,identified key risk factors and projected the future burden of self-harm mortality through 2050.Results Global self-harm deaths among older adults increased from 116642 in 1990 to 167920 in 2021,a rise of 43.96%.However,the age-standardised mortality rate(ASMR)decreased by 39.56%,from 36.83 to 22.26per 100000.In 2021,central sub-Saharan Africa had the highest ASMR at 61.35 per 100000,while North Africa and the Middle East recorded the lowest at 4.88 per100000.Male ASMR was 2.5 times as high as that of females(33.61 vs.13.58 per 100000),and adults aged85 years and older were at particularly elevated risk.High alcohol use was identified as a major risk factor,especially for males.A U-shaped relationship between ASMR and the SDI was observed,with the lowest point at an SDI of approximately 0.70.Projections indicate a further 46.05%decline in ASMR to 12.01 per 100000 by2050.Conclusions These results highlight complex global trends in self-harm mortality and associated risk factors among older adults,emphasising the urgent need for sex-,age-,and region-specific interventions,enhanced social support and systematic risk monitoring to inform age-friendly self-harm prevention policies,and sustainable development support goals. 展开更多
关键词 risk factors socio demographic index global burden age standardised mortality rate adults aged spatiotemporal patterns mortality self harm
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Ischemic Stroke Burden in China and Other G20 Nations(1990-2021):A Comparative Analysis From the Global Burden of Disease Study 2021 and Trend Projections Through 2031 认领 引用
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作者 Bin Luo Yi Xiang +2 位作者 Hecheng Ren Lin Ma Ying Huang 《Health Care Science》 CSCD 2026年第2期141-157,共17页
Background:Ischemic stroke(IS)persists as a major global health challenge.This study assesses IS burden,epidemiological trends,and associations with the Socio-demographic Index(SDI)across China and G20 nations(1990-20... Background:Ischemic stroke(IS)persists as a major global health challenge.This study assesses IS burden,epidemiological trends,and associations with the Socio-demographic Index(SDI)across China and G20 nations(1990-2021),projecting trends to 2031 to inform resource prioritization.Methods:Utilizing Global Burden of Disease(GBD)2021 data,we analyzed age-standardized incidence rates(ASIR)and age-standardized mortality rates(ASMR),disability-adjusted life years(DALYs),and mortality-to-incidence ratio(MIR)using Joinpoint regression(trends),autoregressive integrated moving average(projections),and Pearson correlation(SDI linkage),stratified by age and sex.Results:From 1990 to 2021,China experienced rising crude IS incidence(+27.4%)contrasting with G20 declines.Although ASMR and DALYs decreased globally,China's ASMR initially increased(1999-2004)before declining,unlike sustained G20 reductions.China's ASIR rose 35.7%versus a 15.6%G20 reduction.Projections indicate stable ASMR with rising ASIR in China,diverging from declining ASMR and stable ASIR in the G20.SDI-linked disparities persisted,with China's ASIR/ASMR exceeding G20 averages relative to SDI.Conclusions:China's distinct trajectory-characterized by rising incidence and delayed mortality decline-underscores the necessity for tailored interventions.Addressing SDI-driven disparities is essential for equitable global prevention and care strategies. 展开更多
关键词 China G20 nationslglobal burden of disease incidence rate ischemic stroke mortality rate
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Numerical Study of Burden Effects on Rock Breakage in Single-Hole Bench Blasting 认领 引用
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作者 Kai Rong Zong-Xian Zhang Li-Yuan Chi 《Computer Modeling in Engineering & Sciences》 SCIE EI 2026年第3期416-440,共25页
Burden is one of the main parameters in blast design.However,field tests,either single-or multi-hole blasts,used to determine an appropriate burden,are difficult to capture crack propagation,evolution of breakage angl... Burden is one of the main parameters in blast design.However,field tests,either single-or multi-hole blasts,used to determine an appropriate burden,are difficult to capture crack propagation,evolution of breakage angle,and the mechanism governing these processes in the rock.In this study,a single-hole bench blasting model is developed using LS-DYNA software to comprehensively investigate the relationship between burden and rock breakage.The simulation results show that the breakage angle decreases with the increase in burden,and the blasted volume reaches a peak value with a burden of 4 m.Meanwhile,backbreak distance increases with increasing burden.The optimum burden in this simulation is found to be 4.0 m,as the ratio of burden to blasthole diameter is equal to 20.62 and the ratio of burden to bench height is 0.44,based on a comprehensive analysis of the blasted volume,average damage,and total damage.Under the optimum burden condition,tensile stress wave regions are simultaneously generated at the free surfaces of both the bench top and bench slope,allowing more effective utilization of the two free surfaces and resulting in a more uniform damage distribution within the burden region. 展开更多
关键词 Numerical simulation bench blasting burden damage distribution
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The Global,Regional,and National Burden of Cardiovascular Diseases Attributable to Household Air Pollution from 1990 to 2021:Findings from the Global Burden of Disease Study 2021 认领 引用
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作者 Zehao Zhao Yong Zeng 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第4期447-463,共17页
Objective This study investigates the global,regional,and national cardiovascular disease(CVD)burden caused by household air pollution(HAP)from 1990 to 2021 across regions,time periods,sexes,and age groups.Methods The... Objective This study investigates the global,regional,and national cardiovascular disease(CVD)burden caused by household air pollution(HAP)from 1990 to 2021 across regions,time periods,sexes,and age groups.Methods The global CVD mortality and disability-adjusted life years(DALYs)attributable to HAP are analyzed to assess their current status and historical trends.Quantitative methods are used to assess health inequalities.Projections up to the year 2040 are made using the Nordpred method.Results In 2021,0.758 million deaths and 18.175 million DALYs were attributed to HAP-related CVD,with age-standardized rates(ASR)for mortality and DALYs of 8.950 and 210.354 per 100,000 individuals,respectively.The disease burden increased with age and was higher in men.While mortality and DALYs rates have decreased over the past three decades,with more significant reductions in low-and middleincome regions,health inequalities persist despite improvements.Projections indicate a slow increase in the CVD burden attributable to HAP by 2040,even as the per capita rates decline.Conclusion Although significant reductions in CVD attributable to HAP have occurred globally,particularly in low-and middle-income countries,disparities persist.Health inequalities have improved but remain significant.As the global population grows and ages,total cases will increase,highlighting the need for continued,targeted interventions. 展开更多
关键词 Global Burden of Disease Cardiovascular disease Ischemic heart disease Stroke Household air pollution
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Navigating the emotional burden: Addressing anxiety and depression across stages of hepatobiliary and pancreatic malignancies 认领 引用 被引量：1
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作者 Mohammad Shahangir Biswas Mosammat Jannatul Mawa 《World Journal of Psychiatry》 SCIE 2026年第1期7-14,共8页
In this editorial,we comment on the study of the Yu et al on psychological distress in patients with hepatobiliary and pancreatic malignancies.Hepatobiliary and pancreatic malignancies include hepatocellular carcinoma... In this editorial,we comment on the study of the Yu et al on psychological distress in patients with hepatobiliary and pancreatic malignancies.Hepatobiliary and pancreatic malignancies include hepatocellular carcinoma,cholangiocarcinoma,gallbladder cancer and pancreatic cancer.These cancers are among the most aggressive and difficult to treat.Although improvements in surgery,drug treatments and palliative care have led to better survival rates and quality of life,the significant psychological impact on patients remains underrecognized.Anxiety and depression are prevalent at every stage of the disease,from the initial diagnosis to treatment,recurrence and end-of-life care.However,these issues often take a backseat to the urgent need to manage physical symptoms.Mental health challenges can greatly affect how well patients follow treatment plans,recover and their overall outlook.Yu et al explore the causes of psychological distress in hepatobiliary and pancreatic cancers,including disease severity,symptom burden,financial stress and fears about life and death.We highlight the importance of regular mental health screenings,psychological support and teamwork in oncology care.By focusing on emotional health alongside physical treatment,doctors can build resilience,improve outcomes and address a frequently ignored aspect of cancer care. 展开更多
关键词 Depression Anxiety Cancer Mental health Caregiver burden
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Global burden of mental disorders among adolescents and young adults,1990-2021:a systematic analysis of the Global Burden of Diseases Study 2021 认领 引用 被引量：2
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作者 Jiayi Tian Na Yan +15 位作者 Xinyi Hu Susu Tian Yuhao Wang Louisa Esi Mackay Yunjiao Luo Yingxue Wang Yihan Wang Yuxuan Liu Blen Dereje Shiferaw Huihang Lan Wenjun Yan Qingzhi Wang Xiuyin Gao Caiyi Zhang Haibo Xu Wei Wang 《General Psychiatry》 CAS CSCD 2025年第6期447-457,共11页
Background Mental disorders pose a significant global health burden,especially after the coronavirus disease2019 pandemic.Aims This study aimed to characterise trends in the burden of mental disorders among adolescent... Background Mental disorders pose a significant global health burden,especially after the coronavirus disease2019 pandemic.Aims This study aimed to characterise trends in the burden of mental disorders among adolescents and young adults by sex,age,sociodemographic index(SDI)quintile,region and country from 1990 to 2021.Methods Estimates and 95%uncertainty intervals(UIs)for disability-adjusted life years(DALYs)were extracted from the Global Burden of Diseases Study 2021.The number and rate of DALYs,as well as the percentage change from 1990 to 2021,were estimated by sex,age,SDI quintile,region and country.Results The number of DALYs for mental disorders increased from 26.1(95%UI 19.3 to 34.4)million to 36.3(95%UI 26.6 to 48.1)million.The DALY rate increased from 1687.8(1245.3 to 2225.4)per 100000 population in1990 to 1923.71408.7 to 2548.4)per 100000 population in 2021,representing a 14%(12%to 16%)increase.Females(16%(13%to 18%))and individuals aged 15-19years(16%(13%to 18%))showed the greatest increase in DALY rates.Between 1990 and 2021,DALY rates rose significantly across all SDI quintiles and regions,except East Asia(-5%(-9%to-1%)).The most rapid increases were observed in parts of Latin America,particularly for anxiety and depressive disorders.Conclusions The global burden of mental disorders among adolescents increased significantly from 1990 to2021,necessitating attention to policies targeting high-risk populations and specific regions. 展开更多
关键词 adolescents trends burden mental disorders global burden young adults sociodemographic index burden diseases disability adjusted life years mental disorders
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Burden of Non-communicable Diseases Attributable to High and Low Ambient Temperatures,1990-2031:A Forecasting Analysis for GBD 2021 认领 引用
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作者 Li Pu Huan-huan Wang +9 位作者 Xiang-wei Cheng Li-bo Luo Xiao-qing Zhang Xia Hu He-qi Peng Lu Ding Bao-zhu Xiao Wen Zhang Xiao-li Wang Pei-hong Wang 《Current Medical Science》 SCIE CAS CSCD 2026年第1期244-255,共12页
Objective Non-communicable diseases(NCDs),characterized by long duration,gradual progression,and high morbidity,have emerged as a fundamental threat to global public health.Furthermore,dramatic climate change may exac... Objective Non-communicable diseases(NCDs),characterized by long duration,gradual progression,and high morbidity,have emerged as a fundamental threat to global public health.Furthermore,dramatic climate change may exacerbate existing trends that worsen the burden of NCDs.Therefore,this study aimed to systematically investigate the patterns and trends of NCDs attributed to nonoptimal temperatures from 1990 to 2021.Methods We utilized data from the Global Burden of Disease Study(GBD)2021 to assess the temporal trends in age-standardized rates(ASR)of deaths and disability-adjusted life-years(DALYs)related to nonoptimal temperature-associated NCDs across 204 countries and territories from 1990 to 2021.Decomposition analysis was applied to quantify the contribu-tion of key factors to this burden.The autoregressive integrated moving average(ARIM A)model was employed to predict trends over the next decade.Results Globally in 2021,NCDs attributable to high temperature(Hi-Tem)accounted for an estimated 302,464.7 deaths(95%uncertainty interval[UI]:171,170.6,472,625.3)and 6,947,660.6 DALYs(95%UI:4,013,964.7,10,611,801.7).The ASR of Hi-Tem-related NCDs deaths and DALYs increased by 35%and 34%between 1990 and 2021.Additionally,the global burden exhibited a significant declining trend in NCDs burden caused by low temperature(Lo-Tem),with 1,477,729.8(95%UI:1,316,829.3,1,631,404.8)deaths and 27,797,533.3(95%UI:25,270,393.5,30,766,299.9)DALYs in 2021.China and India had the highest number of deaths and DALYs for NCDs related to Hi-Tem and Lo-Tem.In 2021,the three leading causes of the NCDs burden attributable to nonoptimal temperature were ischemic heart disease,stroke,and chronic obstructive pulmonary disease.Men and older adults were consistently vulnerable to temperature,showing the greater burden of NCDs attributable to nonoptimal temperature,and aging would exacerbate this trend.The ARIMA model projected an increasing trend in Hi-Tem-related NCDs over the coming decade,while those related to Lo-Tem would show a downward trend.Conclusion The burden of NCDs associated with Hi-Tem has conspicuously increased in recent years compared to that associated with Lo-Tem,with significant diversity across age,sex,and socio-demographic index(SDI)levels.Therefore,public health strategies should prioritize tailored interventions for heterogeneous risk profiles across vulnerable populations,integrated with climate-resilient surveillance systems and real-time adaptive response mechanisms to mitigate projected climate-mediated exacerbations of NCD burden. 展开更多
关键词 Non-communicable diseases High temperature Low temperature Global Burden of Disease Climate change Forecasting GBD 2021
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Global,regional,and national burdens of acute respiratory infections among children and adolescents from 1990 to 2021:A systematic analysis 认领 引用
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作者 Xiang Meng Sijie Li +4 位作者 Meiyan Li Husheng Xiong Xuejuan Chen Yonghui Zhong Dingmei Zhang 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2026年第2期51-60,I0001-I0061,共10页
Objective:To evaluate the global,regional,and national burden and determinants of Acute Respiratory Infections(ARIs)among children and adolescents from 1990 to 2021.Methods:We analysed ARI mortality and disability-adj... Objective:To evaluate the global,regional,and national burden and determinants of Acute Respiratory Infections(ARIs)among children and adolescents from 1990 to 2021.Methods:We analysed ARI mortality and disability-adjusted life years(DALYs),stratified by age,sex,and economic development level based on data retrieved from the Global Burden of Disease study 2021.Decomposition and frontier analyses were employed to identify key drivers of burden variation and visualize potential reductions based on development levels.Results:Between 1990 and 2021,the global burden of ARIs showed a significant decline in both achievable age-standardized DALYs rate and age-standardized mortality rates(EAPC=-3.87 and-3.81,respectively).Different age groups and sex witnessed different levels of ARI burden,males experienced heavier burden than females and the 0-4 years-old group experienced heavier burden than other study age groups.Most of the 204 countries and territories experienced a downward trend of ARI burden,with slight increases observed only in Lesotho and Dominica.A negative correlation was found between the Socio-demographic Index and ARI burden.Decomposition analysis indicated that the significant decreases in deaths and DALYs were primarily driven by epidemiological changes.Conclusions:The global burden of ARIs among children and adolescents has declined over the past three decades,but substantial regional disparities persist.Targeted public health strategies are needed to address the continued ARI burden in high-risk regions and vulnerable age groups. 展开更多
关键词 Respiratory infection Global disease burden Decomposition analysis Frontier analysis
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Sex differences in the global burden of autism spectrum disorders:An analysis based on GBD 2021 data 认领 引用
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作者 LIU Huiqin DING Jinfeng +7 位作者 XU Daxin YUAN Jinqiu NI Zhao LIU Bangshan CHANG Chunwei LIN Jialing JI Binbin QIN Xiwen 《中南大学学报（医学版）》 CAS CSCD 北大核心 2026年第2期299-311,共13页
Objective:Autism spectrum disorder(ASD)has become an increasingly serious global public health challenge,with a continuously rising disease burden and marked sex differences.This study aims to evaluate the long-term t... Objective:Autism spectrum disorder(ASD)has become an increasingly serious global public health challenge,with a continuously rising disease burden and marked sex differences.This study aims to evaluate the long-term trends and global distribution patterns of sex differences in the burden of ASD and to project future changes,thereby providing evidence for ASD prevention and management.Methods:Based on the Global Burden of Disease(GBD)2021 data,disability-adjusted life years(DALYs)for ASD were extracted for 204 countries and territories.Combined with the sociodemographic index(SDI),the average annual percentage change(AAPC)was used to analyze sex differences in temporal trends and spatial distribution of ASD burden from 1990 to 2021,and to project trends from 2022 to 2050.Results:From 1990 to 2021,the global age-standardized DALY rate(ASDR)for ASD was significantly higher in males than in females,and this pattern is projected to persist through 2050.The absolute difference(AD)in ASDR ranged from 103.5 to 105.3 per 100000,and the relative difference(RD)ranged from 1.0 to 1.1,with the most pronounced sex differences observed in East Asia and high-SDI regions.The male ASDR showed an increasing trend from 1990 to 2021,whereas the female ASDR is projected to increase after 2021,particularly in Africa.In 2021,global DALYs for ASD peaked among children under 5 years of age(221.9 per 100000 in males and 112.8 per 100000 in females),and the relative difference in DALYs increased with age.The absolute difference in DALYs during adulthood generally declined but increased among young adults and those aged≥70 years,consistent with the pattern observed for relative differences.At the national level,sex differences were positively correlated with SDI and universal health coverage(UHC),and negatively correlated with the gender inequality index(GII)(all P<0.001).Spain,Japan,Singapore,South Korea,and China were identified as outliers to these associations.Conclusion:Sex differences in the burden of ASD persist globally and increase with age.Targeted prevention and control strategies tailored to different sexes and age groups are warranted. 展开更多
关键词 autism spectrum disorder sex differences Global Burden of Disease disability-adjusted life years sociodemographic factors
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National and subnational burden and causes of anemia in China from 1990 to 2023:findings from the Global Burden of Disease Study 2023 认领 引用
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作者 Zheng Long Ling-Ling Yu +5 位作者 Fan-Shu Yan Pei-Pei Li Li-Jun Wang Mai-Geng Zhou Bing-Xin Ji Peng Yin 《Military Medical Research》 SCIE CAS CSCD 2026年第7期1042-1060,共19页
Background:Anemia is a major global health problem.There were 89%of all anemia-related disabilities in developing countries.We aim to analyze the burden of anemia and its underlying causes in China from 1990 to 2023.M... Background:Anemia is a major global health problem.There were 89%of all anemia-related disabilities in developing countries.We aim to analyze the burden of anemia and its underlying causes in China from 1990 to 2023.Methods:Utilizing the data of the 2023 Global Burden of Disease(GBD 2023)study,this study analyzed the burden of anemia in China between 1990 and 2023.Then we analyzed the number and rate of anemia attributed to16 underlying causes for all genders and ages.Drivers of change in prevalence and years lived with disability(YLD)numbers due to anemia were explored by decomposition analysis.And locally weighted regression was used to estimate the relationship between socio-demographic index(SDI)and age-standardized prevalence rate(ASPR)and age-standardized YLD rate due to anemia.Results:From 1990 to 2023,the ASPR and age-standardized YLD rate showed a downward trend among all anemia types(P<0.05),and the ASPR and age-standardized YLD rate of anemia in females were higher than those in males.The highest number and rate of prevalence were found in mild anemia,and the highest number and rate of YLD were found in moderate anemia.As age increased,the prevalence and YLD rate of anemia increased,with a significant increase in females aged 20-54 years,in particular of moderate anemia.In 2023,the highest ASPR and agestandardized YLD rate among all anemia types were in the Northwestern regions.Compared to 1990,31 provinces,Hong Kong,and Macao exhibited declines in both the ASPR and the age-standardized YLD rate for anemia.In China,most of the prevalent cases and YLD were attributable to dietary iron deficiency in 2023.The total prevalence of anemia decreased by 46.14%[95%uncertainty interval(UI)27.54-61.02],of which age-specific rate,population growth,and population aging accounted for-77.32%,21.33%,and 9.84%,respectively.A negative association between SDI and the ASPR and age-standardized YLD rate of anemia was shown in China.Conclusions:From 1990 to 2023,the burden of anemia in China has decreased but remained heavy among women of childbearing age,the elderly,and in the Northwestern region.Tailored prevention and control strategies should be strengthened to reduce the burden of anemia in high-risk areas. 展开更多
关键词 Anemia Prevalence Years lived with disability(YLD) Burden of disease Trend
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Global Trends in Early-Onset Ischemic Heart Disease Linked to Obesity,1990–2021:Insights from the Global Burden of Disease Study 认领 引用
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作者 YANG Liujia JI Hongwei +9 位作者 ZHANG Jiawen HUANG Honghao XU Wei WANG Donghao ZHANG Zheng HUANG Xinyue LIU Qi ZHONG Yiming CHEN Yifan PU Jun 《Journal of Shanghai Jiaotong university(Science)》 EI 2026年第3期800-810,I0048,共11页
Obesity is a major modifiable risk factor for early-onset ischemic heart disease(IHD),yet its contribution to the global burden across regions and demographics is not fully quantified.This study assesses global trends... Obesity is a major modifiable risk factor for early-onset ischemic heart disease(IHD),yet its contribution to the global burden across regions and demographics is not fully quantified.This study assesses global trends in obesity-related early-onset IHD,focusing on young adults(aged 25–39 years).We utilized Global Burden of Disease Study 2021 data to track 30-year trends in obesity and early-onset IHD via average annual percentage changes(AAPCs)and socio-demographic index(SDI)-stratified disability-adjusted life year(DALY)counts.Pearson correlation was then applied to evaluate the associations between these variables.Further multi-factor adjustment analysis was conducted using a multivariable linear regression model on 5-year age-stratified data.A significant positive correlation was found between the AAPC in obesity age-standardized prevalence rate(ASPR)and the AAPC in early-onset IHD age-standardized mortality rate(ASMR)(ρ=0.36,P<0.001)and ASPR(ρ=0.29,P<0.001)among young males,with stronger associations than in females.The impact of obesity on early-onset IHD prevalence and mortality strengthened with age,peaking at 35–39 years old for both male and female.Even after having adjusted for dietary,environmental,and metabolic risk factors,obesity remains the top IHD risk factor in almost all subgroups.Clearly,obesity is strongly linked to higher morbidity and mortality in early-onset IHD. 展开更多
关键词 early-onset ischemic heart disease(IHD) obesity Global Burden of Disease
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Burden of antimicrobial resistance in the WHO Southeast Asia and Western Pacific Regions,1990–2021:a cross-country systematic analysis with forecasts to 2050 认领 引用
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作者 Xiao-Ran Yu Huan Wang +7 位作者 Jian Wang Xin Yuan Xiao-Ding Zhou Qiu-Shui He Igor Mokrousov Lin Sun Yan-Hui Dong Zhi-Yong Zou 《Military Medical Research》 SCIE CAS CSCD 2026年第7期1081-1101,共21页
Background:Antimicrobial resistance(AMR)constitutes a critical global health challenge with major implications for public health and economic stability,increasing infection-and sepsis-related mortality.Despite growing... Background:Antimicrobial resistance(AMR)constitutes a critical global health challenge with major implications for public health and economic stability,increasing infection-and sepsis-related mortality.Despite growing evidence on its contribution to disease burden,comprehensive assessments of long-term trends at the regional level remain limited in the World Health Organization(WHO)Southeast Asia Region(SEAR)and Western Pacific Region(WPR).Methods:We used data from the Global Research on Antimicrobial Resistance(GRAM)Project to evaluate sepsisand AMR-related deaths and disability-adjusted life-years(DALYs)for 11 infectious syndromes,22 pathogens,and 84pathogen-drug combinations across 42 countries and territories in the WHO SEAR and WPR from 1990 to 2021.AMR burden was estimated under two counterfactual scenarios:deaths and DALYs attributable to AMR(representing the burden if drug-resistant infections were replaced by drug-susceptible infections),and deaths and DALYs associated with AMR(representing the burden if infections did not occur at all).We reported numbers,crude rates,and agestandardized rates,and generated forecasts of AMR burden to 2050 using an autoregressive integrated moving average model.Results:In SEAR and WPR,there were 8.36×106[95%uncertainty interval(UI)7.93-8.79]sepsis-related deaths in 1990,which decreased to 6.03×106(95%UI 5.68-6.39)in 2019 before increasing to 8.31×106(95%UI 7.86-8.76)in 2021.The number of deaths associated with AMR ranged from 2,445,875(95%UI 2,221,769-2,670,192)in 1990 to 2,358,190(95%UI2,173,521-2,545,190)in 2021,while deaths attributable to AMR ranged from 546,479(95%UI 487,669-605,277)to587,103(95%UI 534,165-639,903)over the same period.From 1990 to 2021,deaths attributable to AMR decreased among people<25 years,with a 76.1%[95%confidence interval(CI)70.6-81.6]reduction occurring among children<5 years,while those among adults aged≥70 years more than doubled,increasing from 133,013(95%UI 124,066-141,922)to 298,366(95%UI 284,023-312,475).The largest increase in the number of deaths attributable to AMR was caused by methicillin-resistant Staphylococcus aureus[from 30,168(95%UI 24,956-35,351)in 1990 to 66,946(95%UI57,544-76,479)in 2021].In 2021,Kiribati had the highest age-standardized mortality rate(per 100,000 person-years)attributable to AMR[30.9(95%UI 24.1-37.8)],whereas New Zealand had the lowest[3.2(95%UI 2.6-3.8)]among the two regions.By 2050,the number of deaths associated with AMR is predicted to reach 3,875,753(95%UI 1,502,402-9,998,297)in these two regions,of which 952,592(95%UI 766,353-1,184,090)deaths are attributable to AMR.Conclusions:This study highlights the escalating burden of AMR in SEAR and WPR,emphasizing the urgent need for attention to this persistent and growing crisis.Our analyses underscore the dual challenge of sustaining gains among people<25 years while addressing the alarming increase of AMR in elderly populations.Given the high variability of AMR burden by pathogen,age group,and country,strengthened surveillance and improved laboratory capacity are essential to accurately characterize resistance patterns and guide clinical decision-making. 展开更多
关键词 Antimicrobial resistance(AMR) Burden Southeast Asia Region(SEAR) Western Pacific Region(WPR)
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Caregiver burden and related factors on caregivers of the elderly with chronic diseases 认领 引用
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作者 Nguyen Thi Huong Lan Huynh Thi Ly Hoang Thi Ngoc Sen 《Frontiers of Nursing》 2026年第1期105-113,共9页
Objective:The aging population is growing rapidly,leading to a rise in chronic diseases and placing significant physical,emotional,and financial strain on caregivers.Managing chronic conditions alongside caregiving re... Objective:The aging population is growing rapidly,leading to a rise in chronic diseases and placing significant physical,emotional,and financial strain on caregivers.Managing chronic conditions alongside caregiving responsibilities often results in burnout,adding to the burden on caregivers.This issue also affects society and healthcare systems through increased costs and greater demands for support services.Understanding the factors contributing to caregiver burden is crucial for creating effective interventions to address these challenges.The aim of this study is to describe the extent of caregiver burden and identify some factors related to burden among caregivers of chronically ill elderly people.By gaining insight into these relationships,this study seeks to identify strategies to reduce the burden on caregivers.Methods:This study utilized a cross-sectional design to examine caregivers of the elderly with chronic diseases receiving treatment in the public healthcare facility.Data collection involved administering structured questionnaires that gathered information on the demographic characteristics of both the elderly and their caregivers,the level of social support received,the functional status of patients as measured by daily activity indices,and the level of caregiver burden.Description was used to elaborate the characteristics of participants.Mann-Whitney,Kruskal-Wallis,and Spearman's correlation test were applied to explore the relationship between variables.Statistical significance was determined at P value<0.05.Results:Caregivers of the elderly with chronic diseases had a moderate care burden score(22.62±11.24,CI:95%).The patients'level of dependence,relationship with the patients,and time spent as a caregiver were factors related to caregiver burden(P<0.05).Conclusions:Those who care for elderly people with chronic diseases suffered great burden.The finding had found a number of factors that influence the caregivers'weight loss.Healthcare providers should consider these relevant factors when developing intervention plans to reduce caregiver burden. 展开更多
关键词 burden of caregivers chronic diseases level of dependence social support the elderly
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Letter to the Editor:Eye as a window to disease burden in pediatric acute leukemia 认领 引用
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作者 Devlina Ghosh 《World Journal of Experimental Medicine》 2026年第2期108-111,共4页
Ocular involvement in pediatric acute leukemia is an increasingly recognized,clinically relevant manifestation,but prevalence and patterns vary.It may arise from direct leukemic infiltration or secondary hematologic a... Ocular involvement in pediatric acute leukemia is an increasingly recognized,clinically relevant manifestation,but prevalence and patterns vary.It may arise from direct leukemic infiltration or secondary hematologic abnormalities.Recent observational studies,including Eastern India cohorts,underscore systematic ophthalmic evaluation at diagnosis.In a cohort of 47 children by Parija et al published in the World Journal of Experimental Medicine,ocular findings were present in 40.4%at presentation;most were asymptomatic and retinal hemorrhages predominated.Other series report similar patterns,with retinal hemorrhages common and prevalence roughly 40%-45%,while pooled meta-analytic estimates suggest an overall prevalence near 20%,differences likely reflect ethnicity,healthcare access,diagnostic protocols,study design,and sample size.Hematologic factors such as anemia and thrombocytopenia favor hemorrhagic lesions,whereas marked leukocytosis and high blast counts associate with infiltrative involvement of the retina,optic nerve,or orbit.Although some studies link ocular involvement to higher disease burden and worse outcomes,evidence is inconsistent because of methodological limitations and short follow-up.These findings support routine baseline ophthalmic screening,even in asymptomatic children,to detect vision-threatening lesions and clearly inform risk assessment.Larger prospective studies with standardized ocular and hematologic correlations are needed to define prognostic significance and optimize screening. 展开更多
关键词 Acute paediatric leukaemia Ocular involvement Leukemic retinopathy Intraretinal hemorrhages Disease burden Ophthalmology
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