Let G be a finite group and H a subgroup of G.The normal index of H in G is defined as the order of K/HG,where K is a normal supplement of H in G such that|K|is minimal and HG≤K■G.Let p be a prime which divide...Let G be a finite group and H a subgroup of G.The normal index of H in G is defined as the order of K/HG,where K is a normal supplement of H in G such that|K|is minimal and HG≤K■G.Let p be a prime which divides the order of a group G.In this paper,some characterizations of G being p-solvable or p-supersolvable were obtained by analyzing the normal index of certain subgroups of G.These results can be viewed as local version of recent results in the literature.展开更多
This paper investigates the in uence of local SS-quasinormal maximal subgroups of Sylow subgroups on the structure of nite groups.We present several new criteria on p-nilpotency of nite groups by utilizing a small qua...This paper investigates the in uence of local SS-quasinormal maximal subgroups of Sylow subgroups on the structure of nite groups.We present several new criteria on p-nilpotency of nite groups by utilizing a small quantity of local SS-quasinormal maximal subgroups of Sylow p-subgroups.As applications,we obtain some sucient conditions for a nite group to be in a saturated formation containing the class of supersolvable groups.展开更多
Porcine reproductive and respiratory syndrome virus 1(PRRSV-1)has emerged as a critical pathogen that threatens swine herds across China.In this study,a novel PRRSV-1 strain,designated XJEU2308,was isolated from a PRR...Porcine reproductive and respiratory syndrome virus 1(PRRSV-1)has emerged as a critical pathogen that threatens swine herds across China.In this study,a novel PRRSV-1 strain,designated XJEU2308,was isolated from a PRRSV outbreak in a previously confirmed PRRSV-negative(both RNA and antibody negative)swine herd in Xinjiang,China.During the outbreak surveillance period,production records revealed a mean stillbirth rate of 12.19%and a suckling piglet mortality rate of 56.07%.Phylogenetic analysis on the basis of the ORF5 gene classified XJEU2308 as a BJEU06-1-like strain,whereas whole-genome analysis clustered it within the newly identified"New subgroup 1"of Chinese PRRSV-1.Notably,this strain carried a unique 3-amino acid deletion(at positions 693-695)in nonstructural protein 2(NSP2).In challenge experiments,XJEU2308 induced typical clinical symptoms and exhibited moderate pathogenic-ity.Importantly,the implementation of the load-close-exposure(LCE)strategy combined with field virus(FLV)expo-sure successfully restored the herd to a provisional PRRSV-negative status.Overall,this study isolated a new subgroup 1-like PRRSV-1 strain from a swine farm that experienced a reproductive failure outbreak;the strain is characterized by a unique 3-amino-acid deletion in the NSP2 gene and moderate pathogenicity.Additionally,this study validated the effectiveness of the LCE-FLV strategy for containing PRRSV-1.展开更多
Human adenoviruses(HAdVs),particularly subgroup B serotypes HAdV-3 and HAdV-55,are associated with severe respiratory disease and currently lack targeted therapies.While neutralizing monoclonal antibodies(nMAbs)offer ...Human adenoviruses(HAdVs),particularly subgroup B serotypes HAdV-3 and HAdV-55,are associated with severe respiratory disease and currently lack targeted therapies.While neutralizing monoclonal antibodies(nMAbs)offer promising therapeutic potential,the specific nMAbs targeting these serotypes remain poorly characterized.Therefore,this study aimed to generate and evaluate the efficacy of serotype-specific nMAbs against HAdV-3 and HAdV-55.Mice were immunized with HAdV-3 virions,HAdV-55 virions,or recombinant fiber knob proteins(HAdV-55/-7)for the generation of serotype-specific nMAbs,and their efficacy was systematically evaluated using in vitro assays and an in vivo tree shrew model.Through comprehensive screening,eleven MAbs were identified with specificity against HAdV-3(six clones)or HAdV-55/-7 fiber knob(five clones).Four nMAbs exhibited potent neutralizing activity:13F12(half-maximal inhibitory concentration,IC50:3.8μg/mL),8D2(IC50:15.1μg/mL),3A3(IC50:14.9μg/mL)against HAdV-3 virions,and 8F2 with neutralizing efficacy against HAdV-55 virions(IC50:30.4μg/mL).Western blot analysis revealed that MAbs 13F12 and 8F2 targeted the fiber protein,whereas 8D2 and 3A3 bound to the hexon protein.Furthermore,in vivo evaluations demonstrated that 13F12 significantly reduced viral loads in nasal turbinates and attenuated lung pathology in HAdV-3-infected tree shrews.Mechanistically,all tested anti-HAdV-3 nMAbs inhibited infection by blocking viral attachment(P<0.01 vs.controls).In conclusion,this study underscores the therapeutic potential of targeting viral entry and highlights 13F12 as a promising candidate for HAdV prophylaxis.展开更多
Let F be a saturated formation containing the class of supersolvable groups and let G be a finite group. The following theorems are shown: (1) G ∈ F if and only if there is a normal subgroup H such that G/H ∈ F a...Let F be a saturated formation containing the class of supersolvable groups and let G be a finite group. The following theorems are shown: (1) G ∈ F if and only if there is a normal subgroup H such that G/H ∈ F and every maximal subgroup of all Sylow subgroups of H is either c-normal or s-quasinormally embedded in G; (2) G ∈F if and only if there is a soluble normal subgroup H such that G/H∈F and every maximal subgroup of all Sylow subgroups of F(H), the Fitting subgroup of H, is either e-normally or s-quasinormally embedded in G.展开更多
Let G be a group and H;K be subgroups of G.H is called a TI-subgroup of G if H∩Hg=1 or H for every g∈G.K is called P-subnormal in G if there is a chain of subgroups K=K0≤K1≤K2≤…≤Kn-1≤Kn=G suc...Let G be a group and H;K be subgroups of G.H is called a TI-subgroup of G if H∩Hg=1 or H for every g∈G.K is called P-subnormal in G if there is a chain of subgroups K=K0≤K1≤K2≤…≤Kn-1≤Kn=G such that|Ki:Ki-1|∈P for i∈{1;2;…;n}.Furthermore,K is called K-P-subnormal in G if there is a chain of subgroups K=K0≤K1≤K2≤…≤Kn-1≤Kn=G such that either Ki-1is normal in Ki or|Ki:Ki-1|∈P for i∈{1;2;…;n}.In this paper,some properties of a nite group in which some particular subgroups are TI-subgroups or P-subnormal subgroups or K-P-subnormal subgroups are given.展开更多
In clinical research,subgroup analysis can help identify patient groups that respond better or worse to specific treatments,improve therapeutic effect and safety,and is of great significance in precision medicine.This...In clinical research,subgroup analysis can help identify patient groups that respond better or worse to specific treatments,improve therapeutic effect and safety,and is of great significance in precision medicine.This article considers subgroup analysis methods for longitudinal data containing multiple covariates and biomarkers.We divide subgroups based on whether a linear combination of these biomarkers exceeds a predetermined threshold,and assess the heterogeneity of treatment effects across subgroups using the interaction between subgroups and exposure variables.Quantile regression is used to better characterize the global distribution of the response variable and sparsity penalties are imposed to achieve variable selection of covariates and biomarkers.The effectiveness of our proposed methodology for both variable selection and parameter estimation is verified through random simulations.Finally,we demonstrate the application of this method by analyzing data from the PA.3 trial,further illustrating the practicality of the method proposed in this paper.展开更多
Let G be a finite group.A subgroup H of G is said to be σ-c-propermutable in G if G has a subgroup B such that G=NG(H)B and for every Hall σi-subgroup Bi of B,there exists an element x∈B such that HBi^(...Let G be a finite group.A subgroup H of G is said to be σ-c-propermutable in G if G has a subgroup B such that G=NG(H)B and for every Hall σi-subgroup Bi of B,there exists an element x∈B such that HBix=Bix H.In this paper,the influence of σ-c-propermutable subgroups on the structure of finite groups is investigated,and some criteria for a normal subgroup of G to be hypercyclically embedded in G are derived.展开更多
In this paper,we introduce the set of maximal subgroups with non-trivial core and their corresponding second maximal subgroups.A correlation characterization of the group class Jpris presented by establishing the r...In this paper,we introduce the set of maximal subgroups with non-trivial core and their corresponding second maximal subgroups.A correlation characterization of the group class Jpris presented by establishing the relationship between the core and the second maximal subgroups in these classifications.展开更多
目的:分析肿瘤患者输血相容性检测过程中的疑难情况,综合不同实验方法准确鉴定血型抗原和抗体,保障患者输血安全。方法:对2021年01月至2024年01月医院送检我中心的肿瘤患者血型及合血疑难样本进一步检测。血清中检出意外抗体的标本进行...目的:分析肿瘤患者输血相容性检测过程中的疑难情况,综合不同实验方法准确鉴定血型抗原和抗体,保障患者输血安全。方法:对2021年01月至2024年01月医院送检我中心的肿瘤患者血型及合血疑难样本进一步检测。血清中检出意外抗体的标本进行抗体筛查、鉴定和对应血型抗原确认;ABO疑难血型标本应用盐水试管法、吸收放散等血清学实验综合判断;疑似亚型标本提取DNA,应用序列特异性引物PCR(PCR-SSP)法进行基因检测,典型标本进行三代测序即单分子实时荧光测序(single molecule real time sequencing,SMRT)分析。结果:255例送检肿瘤患者疑难样本中,148例检出意外抗体,出现频率以抗-Lea最高(21.9%),其次为抗-E(20.6%)、抗-M(18.7%),26例样本(16.8%)未确定抗体特异性。107例样本血型鉴定困难:43例样本ABO血型复核无异常,35例样本ABO血型抗体减弱,29例样本表现为血清学亚型,其中PCR-SSP证实11例为亚型。3例典型样本血清学表现为A亚B,PCR-SSP基因分型结果分别为B(A)02/O01,B(A)04/O02,A1B;SMRT测序基因分型结果分别为ABO*BA.02/O.01.01,ABO*BA.04/O.01.02,ABO*A1.02/B.01,未发现新突变。结论:血型意外抗体、ABO血型抗原减弱及抗体减弱是构成肿瘤患者输血相容性检测疑难问题的主要原因。未来可考虑将RH和MNS血型抗原纳入献血者检测范围,并引入分子生物学技术,为患者制定个体化输血策略提供参考。展开更多
基金Supported by the National Natural Science Foundation of China(Grant No.12071092)Guangdong Basic and Applied Basic Research Foundation(Grant No.2025A1515012072)+1 种基金the Natural Science Research Project of Anhui Educational Committee(Grant No.2024AH051298)the Scientific Research Foundation of Bozhou University(Grant No.BYKQ202419).
摘要Let G be a finite group and H a subgroup of G.The normal index of H in G is defined as the order of K/HG,where K is a normal supplement of H in G such that|K|is minimal and HG≤K■G.Let p be a prime which divides the order of a group G.In this paper,some characterizations of G being p-solvable or p-supersolvable were obtained by analyzing the normal index of certain subgroups of G.These results can be viewed as local version of recent results in the literature.
基金Supported by NSF of China(12061011)NSF of Guangxi(2023GXN-SFAA026333)。
摘要This paper investigates the in uence of local SS-quasinormal maximal subgroups of Sylow subgroups on the structure of nite groups.We present several new criteria on p-nilpotency of nite groups by utilizing a small quantity of local SS-quasinormal maximal subgroups of Sylow p-subgroups.As applications,we obtain some sucient conditions for a nite group to be in a saturated formation containing the class of supersolvable groups.
基金supported by grants from the Science and Technology Development Plan Project of the Silk Road Economic Belt Innovation-Driven Development Pilot Zone and the Urumqi-Changji-Shihezi National Innovation Demonstration Zone(2022LQ01003)National Defense Science and Technology Innovation Fund of the Chinese Academy of Sciences,2022LQ01003,anding zhang。
摘要Porcine reproductive and respiratory syndrome virus 1(PRRSV-1)has emerged as a critical pathogen that threatens swine herds across China.In this study,a novel PRRSV-1 strain,designated XJEU2308,was isolated from a PRRSV outbreak in a previously confirmed PRRSV-negative(both RNA and antibody negative)swine herd in Xinjiang,China.During the outbreak surveillance period,production records revealed a mean stillbirth rate of 12.19%and a suckling piglet mortality rate of 56.07%.Phylogenetic analysis on the basis of the ORF5 gene classified XJEU2308 as a BJEU06-1-like strain,whereas whole-genome analysis clustered it within the newly identified"New subgroup 1"of Chinese PRRSV-1.Notably,this strain carried a unique 3-amino acid deletion(at positions 693-695)in nonstructural protein 2(NSP2).In challenge experiments,XJEU2308 induced typical clinical symptoms and exhibited moderate pathogenic-ity.Importantly,the implementation of the load-close-exposure(LCE)strategy combined with field virus(FLV)expo-sure successfully restored the herd to a provisional PRRSV-negative status.Overall,this study isolated a new subgroup 1-like PRRSV-1 strain from a swine farm that experienced a reproductive failure outbreak;the strain is characterized by a unique 3-amino-acid deletion in the NSP2 gene and moderate pathogenicity.Additionally,this study validated the effectiveness of the LCE-FLV strategy for containing PRRSV-1.
基金supported by the National Natural Science Foundation of China[No.82371846,No.32170939,No.32411540019,No.W2421121]Guangdong Basic and Applied Basic Research Foundation[No.2022B1515020075]+2 种基金Guangdong Science and Technology Program key projects[No.2021B1212030014]The Science and Technology Program of Guangzhou[No.2025A04J6161]Guangdong Provincial Science and Technology Plan Project-International Science and Technology Cooperation Field(Grant No.2025A0505020047).
摘要Human adenoviruses(HAdVs),particularly subgroup B serotypes HAdV-3 and HAdV-55,are associated with severe respiratory disease and currently lack targeted therapies.While neutralizing monoclonal antibodies(nMAbs)offer promising therapeutic potential,the specific nMAbs targeting these serotypes remain poorly characterized.Therefore,this study aimed to generate and evaluate the efficacy of serotype-specific nMAbs against HAdV-3 and HAdV-55.Mice were immunized with HAdV-3 virions,HAdV-55 virions,or recombinant fiber knob proteins(HAdV-55/-7)for the generation of serotype-specific nMAbs,and their efficacy was systematically evaluated using in vitro assays and an in vivo tree shrew model.Through comprehensive screening,eleven MAbs were identified with specificity against HAdV-3(six clones)or HAdV-55/-7 fiber knob(five clones).Four nMAbs exhibited potent neutralizing activity:13F12(half-maximal inhibitory concentration,IC50:3.8μg/mL),8D2(IC50:15.1μg/mL),3A3(IC50:14.9μg/mL)against HAdV-3 virions,and 8F2 with neutralizing efficacy against HAdV-55 virions(IC50:30.4μg/mL).Western blot analysis revealed that MAbs 13F12 and 8F2 targeted the fiber protein,whereas 8D2 and 3A3 bound to the hexon protein.Furthermore,in vivo evaluations demonstrated that 13F12 significantly reduced viral loads in nasal turbinates and attenuated lung pathology in HAdV-3-infected tree shrews.Mechanistically,all tested anti-HAdV-3 nMAbs inhibited infection by blocking viral attachment(P<0.01 vs.controls).In conclusion,this study underscores the therapeutic potential of targeting viral entry and highlights 13F12 as a promising candidate for HAdV prophylaxis.
基金the Natural Science Foundation of Chinathe Natural Science Foundation of Guangxi Autonomous Region (No.0249001)
摘要Let F be a saturated formation containing the class of supersolvable groups and let G be a finite group. The following theorems are shown: (1) G ∈ F if and only if there is a normal subgroup H such that G/H ∈ F and every maximal subgroup of all Sylow subgroups of H is either c-normal or s-quasinormally embedded in G; (2) G ∈F if and only if there is a soluble normal subgroup H such that G/H∈F and every maximal subgroup of all Sylow subgroups of F(H), the Fitting subgroup of H, is either e-normally or s-quasinormally embedded in G.
摘要Let G be a group and H;K be subgroups of G.H is called a TI-subgroup of G if H∩Hg=1 or H for every g∈G.K is called P-subnormal in G if there is a chain of subgroups K=K0≤K1≤K2≤…≤Kn-1≤Kn=G such that|Ki:Ki-1|∈P for i∈{1;2;…;n}.Furthermore,K is called K-P-subnormal in G if there is a chain of subgroups K=K0≤K1≤K2≤…≤Kn-1≤Kn=G such that either Ki-1is normal in Ki or|Ki:Ki-1|∈P for i∈{1;2;…;n}.In this paper,some properties of a nite group in which some particular subgroups are TI-subgroups or P-subnormal subgroups or K-P-subnormal subgroups are given.
基金Supported by the Natural Science Foundation of Fujian Province(2022J011177,2024J01903)the Key Project of Fujian Provincial Education Department(JZ230054)。
摘要In clinical research,subgroup analysis can help identify patient groups that respond better or worse to specific treatments,improve therapeutic effect and safety,and is of great significance in precision medicine.This article considers subgroup analysis methods for longitudinal data containing multiple covariates and biomarkers.We divide subgroups based on whether a linear combination of these biomarkers exceeds a predetermined threshold,and assess the heterogeneity of treatment effects across subgroups using the interaction between subgroups and exposure variables.Quantile regression is used to better characterize the global distribution of the response variable and sparsity penalties are imposed to achieve variable selection of covariates and biomarkers.The effectiveness of our proposed methodology for both variable selection and parameter estimation is verified through random simulations.Finally,we demonstrate the application of this method by analyzing data from the PA.3 trial,further illustrating the practicality of the method proposed in this paper.
摘要Let G be a finite group.A subgroup H of G is said to be σ-c-propermutable in G if G has a subgroup B such that G=NG(H)B and for every Hall σi-subgroup Bi of B,there exists an element x∈B such that HBix=Bix H.In this paper,the influence of σ-c-propermutable subgroups on the structure of finite groups is investigated,and some criteria for a normal subgroup of G to be hypercyclically embedded in G are derived.
基金Supported by the National Natural Science Foundation of China(Grant Nos.1237101812201236)+1 种基金the Fundamental Research Funds for the Central Universities(Grant No.B240201093/2013)the Natural Science Foundation of the Anhui Higher Education Institutions(Grant No.2022AH051907)。
摘要In this paper,we introduce the set of maximal subgroups with non-trivial core and their corresponding second maximal subgroups.A correlation characterization of the group class Jpris presented by establishing the relationship between the core and the second maximal subgroups in these classifications.
摘要目的:分析肿瘤患者输血相容性检测过程中的疑难情况,综合不同实验方法准确鉴定血型抗原和抗体,保障患者输血安全。方法:对2021年01月至2024年01月医院送检我中心的肿瘤患者血型及合血疑难样本进一步检测。血清中检出意外抗体的标本进行抗体筛查、鉴定和对应血型抗原确认;ABO疑难血型标本应用盐水试管法、吸收放散等血清学实验综合判断;疑似亚型标本提取DNA,应用序列特异性引物PCR(PCR-SSP)法进行基因检测,典型标本进行三代测序即单分子实时荧光测序(single molecule real time sequencing,SMRT)分析。结果:255例送检肿瘤患者疑难样本中,148例检出意外抗体,出现频率以抗-Lea最高(21.9%),其次为抗-E(20.6%)、抗-M(18.7%),26例样本(16.8%)未确定抗体特异性。107例样本血型鉴定困难:43例样本ABO血型复核无异常,35例样本ABO血型抗体减弱,29例样本表现为血清学亚型,其中PCR-SSP证实11例为亚型。3例典型样本血清学表现为A亚B,PCR-SSP基因分型结果分别为B(A)02/O01,B(A)04/O02,A1B;SMRT测序基因分型结果分别为ABO*BA.02/O.01.01,ABO*BA.04/O.01.02,ABO*A1.02/B.01,未发现新突变。结论:血型意外抗体、ABO血型抗原减弱及抗体减弱是构成肿瘤患者输血相容性检测疑难问题的主要原因。未来可考虑将RH和MNS血型抗原纳入献血者检测范围,并引入分子生物学技术,为患者制定个体化输血策略提供参考。