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Performance of CO2/H2O Co-Electrolysis in a Flat-Tube Solid Oxide Electrolysis Cell Stack under an Air-Free Environment 认领 引用 被引量：1
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作者 Xiao-Hui Zhong Fei Wang +3 位作者 An-Qi Wu Bei-Bei Han Jian-Xin Wang Wan-Bing Guan 《电化学（中英文）》 CAS 北大核心 2025年第4期24-31,共8页
This work investigates the transient performance and stability of CO2/H2O co-electrolysis in an air-free environment using a flat-tube solid oxide electrolysis cell(SOEC)stack.The results showed that the transie... This work investigates the transient performance and stability of CO2/H2O co-electrolysis in an air-free environment using a flat-tube solid oxide electrolysis cell(SOEC)stack.The results showed that the transient behavior of the stack with and without blowing gas into the air electrode is almost the same.With a current density of 0.67 A·cm-2@750℃,the stack operated for over 200 h under co-electrolysis conditions without air blowing,and the voltage drop rate of the stack was approximately 0.203%/100 hours.Microstructure analysis revealed a significant loss of nickel particles and an apparent for-mation of an insulating phase strontium chromate(SrCrO4)on the surface of the current collection layer of the air electrode,which are identified as key factors contributing to the performance degradation of the stack.This study provides a reference for development of efficient fuel preparation technology based on SOEC stack in airless environments. 展开更多
关键词 Co-electrolysis Stability Air-free Electrolysis stack Solid oxide electrolysis cell
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基于Stacking算法与钻进参数的岩石单轴抗压强度预测 认领 引用 被引量：4
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作者 岳中文 龙思晨 +5 位作者 闫逸飞 张梦佳 胡昊 薛克军 马文彪 李杨 《采矿与安全工程学报》 EI CAS CSCD 北大核心 2026年第1期198-207,共10页
针对传统岩石强度参数测试方法周期长、成本高的问题,本文提出一种基于Stacking集成算法的新型岩石单轴抗压强度预测方法。通过自主研发的岩石数字钻探测试系统,对不同强度材料的组合试件开展数字钻探试验;选择4种不同的机器学习算法(... 针对传统岩石强度参数测试方法周期长、成本高的问题,本文提出一种基于Stacking集成算法的新型岩石单轴抗压强度预测方法。通过自主研发的岩石数字钻探测试系统,对不同强度材料的组合试件开展数字钻探试验;选择4种不同的机器学习算法(包括支持向量机、随机森林、LightGBM和BP-神经网络),利用钻进数据训练相应的算法模型,探究钻进速度、扭矩和推进力与岩石单轴抗压强度之间的关系;采用双层Stacking框架融合4种抗压强度预测模型,构建集成算法模型,以解决单一算法模型预测精度不足、泛化能力差的问题。研究结果表明,Stacking算法模型在不同转速下对岩石单轴抗压强度的预测性能优异,300 r/min转速与400 r/min转速下对不同试件的单轴抗压强度预测结果决定系数R2基本高于0.9,优于其他4种基学习器,且平均绝对误差占实际强度值的比例小于5%。现场应用表明,Stacking算法模型能有效预测巷道岩层的岩石单轴抗压强度,可为岩体随钻探测研究提供新的思路和方法。 展开更多
关键词 钻进参数 Stacking算法 强度预测 集成学习 模型融合
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Enhanced neurogenesis after ischemic stroke:The interplay between endogenous and exogenous stem cells 认领 引用 被引量：3
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作者 Ruxu Geng Yuhe Wang +2 位作者 Renzhi Wang Jun Wu Xinjie Bao 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期212-223,共12页
Ischemic stroke is a significant global health crisis,frequently resulting in disability or death,with limited therapeutic interventions available.Although various intrinsic reparative processes are initiated within t... Ischemic stroke is a significant global health crisis,frequently resulting in disability or death,with limited therapeutic interventions available.Although various intrinsic reparative processes are initiated within the ischemic brain,these mechanisms are often insufficient to restore neuronal functionality.This has led to intensive investigation into the use of exogenous stem cells as a potential therapeutic option.This comprehensive review outlines the ontogeny and mechanisms of activation of endogenous neural stem cells within the adult brain following ischemic events,with focus on the impact of stem cell-based therapies on neural stem cells.Exogenous stem cells have been shown to enhance the proliferation of endogenous neural stem cells via direct cell-tocell contact and through the secretion of growth factors and exosomes.Additionally,implanted stem cells may recruit host stem cells from their niches to the infarct area by establishing so-called“biobridges.”Furthermore,xenogeneic and allogeneic stem cells can modify the microenvironment of the infarcted brain tissue through immunomodulatory and angiogenic effects,thereby supporting endogenous neuroregeneration.Given the convergence of regulatory pathways between exogenous and endogenous stem cells and the necessity for a supportive microenvironment,we discuss three strategies to simultaneously enhance the therapeutic efficacy of both cell types.These approaches include:(1)co-administration of various growth factors and pharmacological agents alongside stem cell transplantation to reduce stem cell apoptosis;(2)synergistic administration of stem cells and their exosomes to amplify paracrine effects;and(3)integration of stem cells within hydrogels,which provide a protective scaffold for the implanted cells while facilitating the regeneration of neural tissue and the reconstitution of neural circuits.This comprehensive review highlights the interactions and shared regulatory mechanisms between endogenous neural stem cells and exogenously implanted stem cells and may offer new insights for improving the efficacy of stem cell-based therapies in the treatment of ischemic stroke. 展开更多
关键词 brain-derived neurotrophic factor endogenous neuroregeneration exosomes hydrogels ischemic stroke mesenchymal stem cells neural stem cells neurogenesis stem cell transplantation
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Long-term aerobic exercise enhances circulating exosomal miR-214-3p to promote endothelial progenitor cell-mediated repair of endothelial damage induced by obesity 认领 引用 被引量：2
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作者 Junhao Huang Peilun Li +6 位作者 Bing Shen Huiwen Gao Shen Wang Pingyu Wang Weiji Deng Dongdong Gao Min Hu 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第6期80-95,共16页
Background Exercise training may counteract the detrimental effects of obesity on endothelial function by enhancing the reparative capabilities of endothelial progenitor cells(EPC);however,the underlying mechanisms of... Background Exercise training may counteract the detrimental effects of obesity on endothelial function by enhancing the reparative capabilities of endothelial progenitor cells(EPC);however,the underlying mechanisms of exercise-induced EPC-mediated endothelial repair are still unclear.The present study aimed to determine the mechanisms by which exercise-induced circulating exosomes protect against endothelial dysfunction induced by obesity.Methods An 8-week aerobic exercise intervention in both obese human participants and high-fat diet-induced obese rats was conducted.Circulating exosomes were isolated and characterized.microRNA sequencing,molecular biology techniques,and functional assays(including proliferation,migration,and luciferase reporter assays)were employed to identify key exosomal microRNAs and their downstream targets.A microRNA-214-3p(miR-214-3p)knockout rat model was used to validate its role in vivo.Results Exercise promoted EPC-mediated repair of endothelial damage and upregulated exosomal miR-214-3p in both obese humans and rats,without altering exosome quantity.miR-214-3p enhanced EPC proliferation and migration directly,by upregulating collagen type I alpha 2 chain(COL1A2)expression,and indirectly,through the phosphatase and tensin homolog,phosphatidylinositol 3-kinase,serinehreonine kinase(PTEN-PI3K-Akt)signaling pathway.Knockout of miR-214-3p abolished the exercise-induced improvements in endothelial and EPC functionalities.The myocardium was identified as an important source of the exercise-induced increase in circulating exosomal miR-214-3p.Conclusion Long-term aerobic exercise promotes endothelial repair in obesity by enriching circulating exosomes with miR-214-3p,which enhances EPC function via the PTEN-PI3K-Akt pathway and direct regulation of COL1A2.These findings reveal a novel exosome-mediated mechanism through which exercise improves vascular health and suggest potential therapeutic strategies for obesity-related endothelial dysfunction. 展开更多
关键词 Obesity Exercise Endothelial cells Endothelial progenitor cells Exosomes
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Monolithic Perovskite/Perovskite/Silicon Triple-Junction Solar Cells:Fundamentals,Progress,and Prospects 认领 引用 被引量：2
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作者 Leiping Duan Xin Cui +2 位作者 Cheng Xu Zhong Chen Jianghui Zheng 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第1期171-197,共27页
Crystalline silicon(c-Si)solar cells,though dominating the photovoltaic market,are nearing their theoretical power conversion efficiencies(PCE)limit of 29.4%,necessitating the adoption of multi-junction technology to ... Crystalline silicon(c-Si)solar cells,though dominating the photovoltaic market,are nearing their theoretical power conversion efficiencies(PCE)limit of 29.4%,necessitating the adoption of multi-junction technology to achieve higher performance.Among these,perovskiteon-silicon-based multi-junction solar cells have emerged as a promising alternative,where the perovskite offering tunable bandgaps,superior optoelectronic properties,and cost-effective manufacturing.Recent announced double-junction solar cells(PSDJSCs)have achieved the PCE of 34.85%,surpassing all other double-junction technologies.Encouragingly,the rapid advancements in PSDJSCs have spurred increased research interest in perovskite/perovskite/silicon triple-junction solar cells(PSTJSCs)in 2024.This triple-junction solar cell configuration demonstrates immense potential due to their optimum balance between achieving a high PCE limit and managing device complexity.This review provides a comprehensive analysis of PSTJSCs,covering fundamental principles,and technological milestones.Current challenges,including current mismatch,open-circuit voltage deficits,phase segregation,and stability issues,and their corresponding strategies are also discussed,alongside future directions to achieve long-term stability and high PCE.This work aims to advance the understanding of the development in PSTJSCs,paving the way for their practical implementation. 展开更多
关键词 Tandem solar cell Perovskite Triple-junciton solar cell Photovoltaic
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Mesenchymal stem cell-derived small extracellular vesicles enhance the therapeutic effect of retinal progenitor cells in retinal degenerative disease rats 认领 引用 被引量：2
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作者 Chunge Ren Min Chen +10 位作者 Bangqi Ren Yuxiao Zeng Qiang Tan Qiyou Li Xue Zhang Yajie Fang Yixiao Zhou Weitao Zhang Fang Chen Baishijiao Bian Yong Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期821-832,共12页
Our previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplanta... Our previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplantation of retinal progenitor cells alone.Bone marrow mesenchymal stem cells regulate and interact with various cells in the retinal microenvironment by secreting neurotrophic factors and extracellular vesicles.Small extracellular vesicles derived from bone marrow mesenchymal stem cells,which offer low immunogenicity,minimal tumorigenic risk,and ease of transportation,have been utilized in the treatment of various neurological diseases.These vesicles exhibit various activities,including anti-inflammatory actions,promotion of tissue repair,and immune regulation.Therefore,novel strategies using human retinal progenitor cells combined with bone marrow mesenchymal stem cell-derived small extracellular vesicles may represent an innovation in stem cell therapy for retinal degeneration.In this study,we developed such an approach utilizing retinal progenitor cells combined with bone marrow mesenchymal stem cell-derived small extracellular vesicles to treat retinal degeneration in Royal College of Surgeons rats,a genetic model of retinal degeneration.Our findings revealed that the combination of bone marrow mesenchymal stem cell-derived small extracellular vesicles and retinal progenitor cells significantly improved visual function in these rats.The addition of bone marrow mesenchymal stem cell-derived small extracellular vesicles as adjuvants to stem cell transplantation with retinal progenitor cells enhanced the survival,migration,and differentiation of the exogenous retinal progenitor cells.Concurrently,these small extracellular vesicles inhibited the activation of regional microglia,promoted the migration of transplanted retinal progenitor cells to the inner nuclear layer of the retina,and facilitated their differentiation into photoreceptors and bipolar cells.These findings suggest that bone marrow mesenchymal stem cell-derived small extracellular vesicles potentiate the therapeutic efficacy of retinal progenitor cells in retinal degeneration by promoting their survival and differentiation. 展开更多
关键词 differentiation inflammation mesenchymal stem cells microglia migration rat retinal degeneration retinal progenitor cells small extracellular vesicles stem cell transplantation
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Overexpression of the inwardly rectifying potassium channel Kir4.1 or Kir4.1 Tyr9Asp in Müller cells exerts neuroprotective effects in an experimental glaucoma model 认领 引用 被引量：3
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作者 Fang Li Zhen Li +6 位作者 Shuying Li Hong Zhou Yunhui Guo Yongchen Wang Bo Lei Yanying Miao Zhongfeng Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第4期1628-1640,共13页
Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells,which is involved in retinal ganglion cell apopt... Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells,which is involved in retinal ganglion cell apoptosis in glaucoma.Modulation of Kir4.1 expression in Müller cells may therefore be a potential strategy for attenuating retinal ganglion cell damage in glaucoma.In this study,we identified seven predicted phosphorylation sites in Kir4.1 and constructed lentiviral expression systems expressing Kir4.1 mutated at each site to prevent phosphorylation.Following this,we treated Müller glial cells in vitro and in vivo with the m Glu R I agonist DHPG to induce Kir4.1 or Kir4.1 Tyr9Asp overexpression.We found that both Kir4.1 and Kir4.1 Tyr9Asp overexpression inhibited activation of Müller glial cells.Subsequently,we established a rat model of chronic ocular hypertension by injecting microbeads into the anterior chamber and overexpressed Kir4.1 or Kir4.1 Tyr9Asp in the eye,and observed similar results in Müller cells in vivo as those seen in vitro.Both Kir4.1 and Kir4.1 Tyr9Asp overexpression inhibited Müller cell activation,regulated the balance of Bax/Bcl-2,and reduced the m RNA and protein levels of pro-inflammatory factors,including interleukin-1βand tumor necrosis factor-α.Furthermore,we investigated the regulatory effects of Kir4.1 and Kir4.1 Tyr9Asp overexpression on the release of pro-inflammatory factors in a co-culture system of Müller glial cells and microglia.In this co-culture system,we observed elevated adenosine triphosphate concentrations in activated Müller cells,increased levels of translocator protein(a marker of microglial activation),and elevated interleukin-1βm RNA and protein levels in microglia induced by activated Müller cells.These changes could be reversed by Kir4.1 and Kir4.1 Tyr9Asp overexpression in Müller cells.Kir4.1 overexpression,but not Kir4.1 Tyr9Asp overexpression,reduced the number of proliferative and migratory microglia induced by activated Müller cells.Collectively,these results suggest that the tyrosine residue at position nine in Kir4.1 may serve as a functional modulation site in the retina in an experimental model of glaucoma.Kir4.1 and Kir4.1 Tyr9Asp overexpression attenuated Müller cell activation,reduced ATP/P2X receptor–mediated interactions between glial cells,inhibited microglial activation,and decreased the synthesis and release of pro-inflammatory factors,consequently ameliorating retinal ganglion cell apoptosis in glaucoma. 展开更多
关键词 apoptosis chronic ocular hypertension glial cell activation Kir4.1 overexpression Kir4.1 Tyr9Asp mutation microglia Müller cells neuroinflammation neuroprotection retinal ganglion cells
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Partial-EMT in oral squamous cell carcinoma:molecular circuitry and clinical translation 认领 引用 被引量：1
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作者 Chunhua Wang Motoharu Sarubo +1 位作者 Siqi Chen Yasusei Kudo 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第1期18-32,共15页
Oral squamous cell carcinoma(OSCC)is a prevalent malignancy with high morbidity and mortality.Globally,about 400000 people are affected,often with a poor quality of life.Its high mortality is mainly due to its aggress... Oral squamous cell carcinoma(OSCC)is a prevalent malignancy with high morbidity and mortality.Globally,about 400000 people are affected,often with a poor quality of life.Its high mortality is mainly due to its aggressive growth and tendency to spread.Epithelial-mesenchymal transition(EMT)is a central regulatory hub driving tumor cell migration and invasion by enabling changes in cell characteristics.During EMT,epithelial cells gradually take on mesenchymal traits,gaining mobility and spreading mo re easily.Recent multi-omics studies show that many cancer cells exist in a hybrid or partial-EMT state,which lies between the full epithelial and mesenchymal forms.Cells in this state are especially invasive and metastatic,with high plasticity that promotes tumor progression.This review summarizes the role of partial-EMT in OSCC,with a focus on how it alters the tumor microenvironment(TME),promotes invasion and metastasis,and influences cancer stem cells(CSCs).We also highlight the link between partial-EMT and treatment resistance in OSCC.Based on these insights,we discuss therapeutic strategies targeting partial-EMT to improve outcomes.Targeting partial-EMT may offer promising strategies to enhance treatment effectiveness and improve patient survival and quality of life. 展开更多
关键词 cancer stem cells partial Epithelial mesenchymal transition oral squamous cell carcinoma emtepithelial cells invasion metastasis treatment resistance therapeutic strategies oral squamous cell carcinoma oscc
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Multifunctional MXene for Thermal Management in Perovskite Solar Cells 认领 引用 被引量：4
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作者 Zhongquan Wan Runmin Wei +5 位作者 Yuanxi Wang Huaibiao Zeng Haomiao Yin Muhammad Azam Junsheng Luo Chunyang Jia 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第1期458-473,共16页
Perovskite solar cells(PSCs)have emerged as promising photovoltaic technologies owing to their remarkable power conversion efficiency(PCE).However,heat accumulation under continuous illumination remains a critical bot... Perovskite solar cells(PSCs)have emerged as promising photovoltaic technologies owing to their remarkable power conversion efficiency(PCE).However,heat accumulation under continuous illumination remains a critical bottleneck,severely affecting device stability and long-term operational performance.Herein,we present a multifunctional strategy by incorporating highly thermally conductive Ti3C2TX MXene nanosheets into the perovskite layer to simultaneously enhance thermal management and optoelectronic properties.The Ti3C2TX nanosheets,embedded at perovskite grain boundaries,construct efficient thermal conduction pathways,significantly improving the thermal conductivity and diffusivity of the film.This leads to a notable reduction in the device’s steady-state operating temperature from 42.96 to 39.97 under 100 mW cm−2 illumination,thereby alleviating heat-induced performance degradation.Beyond thermal regulation,Ti3C2TX,with high conductivity and negatively charged surface terminations,also serves as an effective defect passivation agent,reducing trap-assisted recombination,while simultaneously facilitating charge extraction and transport by optimizing interfacial energy alignment.As a result,the Ti3C2TX-modified PSC achieve a champion PCE of 25.13%and exhibit outstanding thermal stability,retaining 80%of the initial PCE after 500 h of thermal aging at 85 and 30±5%relative humidity.(In contrast,control PSC retain only 58%after 200 h.)Moreover,under continuous maximum power point tracking in N2 atmosphere,Ti3C2TX-modified PSC retained 70%of the initial PCE after 500 h,whereas the control PSC drop sharply to 20%.These findings highlight the synergistic role of Ti3C2TX in thermal management and optoelectronic performance,paving the way for the development of high-efficiency and heat-resistant perovskite photovoltaics. 展开更多
关键词 Perovskite solar cells Heat accumulation Thermal management Multifunctional MXene Defect passivation
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Induced pluripotent stem cell-derived mesenchymal stem cells enhance acellular nerve allografts to promote peripheral nerve regeneration by facilitating angiogenesis 认领 引用 被引量：2
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作者 Fan-Qi Meng Chao-Chao Li +14 位作者 Wen-Jing Xu Jun-Hao Deng Yan-Jun Guan Tie-Yuan Zhang Bo-Yao Yang Jian Zhang Xiang-Ling Li Feng Han Zhi-Qi Ren Shuai Xu Yan Liang Wen Jiang Jiang Peng Yu Wang Hai-Ying Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期2050-2059,共10页
Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic nerve grafting with bone marrow mesenchymal stem cells.However,adult tissue–derived mesenchymal stem cells en... Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic nerve grafting with bone marrow mesenchymal stem cells.However,adult tissue–derived mesenchymal stem cells encounter various obstacles,including limited tissue sources,invasive acquisition methods,cellular heterogeneity,purification challenges,cellular senescence,and diminished pluripotency and proliferation over successive passages.In this study,we used induced pluripotent stem cell-derived mesenchymal stem cells,known for their self-renewal capacity,multilineage differentiation potential,and immunomodulatory characteristics.We used induced pluripotent stem cell-derived mesenchymal stem cells in conjunction with acellular nerve allografts to address a 10 mm-long defect in a rat model of sciatic nerve injury.Our findings reveal that induced pluripotent stem cell-derived mesenchymal stem cells exhibit survival for up to 17 days in a rat model of peripheral nerve injury with acellular nerve allograft transplantation.Furthermore,the combination of acellular nerve allograft and induced pluripotent stem cell-derived mesenchymal stem cells significantly accelerates the regeneration of injured axons and improves behavioral function recovery in rats.Additionally,our in vivo and in vitro experiments indicate that induced pluripotent stem cell-derived mesenchymal stem cells play a pivotal role in promoting neovascularization.Collectively,our results suggest the potential of acellular nerve allografts with induced pluripotent stem cell-derived mesenchymal stem cells to augment nerve regeneration in rats,offering promising therapeutic strategies for clinical translation. 展开更多
关键词 acellular nerve allograft angiogenesis bioluminescence imaging conditioned medium induced pluripotent stem cell–derived mesenchymal stem cells micro-CT scanning Microfil perfusion peripheral nerve injury
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Identification of GLDN^(+)odontogenic stem cells as crucial for human tooth development and regeneration 认领 引用 被引量：1
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作者 Chengcheng Liao Jinglun Liu +9 位作者 Maojiao Li Bingqian Yang Yejia Yu Jian Yang Xiaoxia Su Shixing Ma Hanchao Li Jingyi Zhang Weidong Tian Li Liao 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第3期386-400,共15页
The dental papilla(DP)is essential for the development of dentin and pulp.The extensive cellular heterogeneity within the DP is a critical factor underlying the complex and precise formation of dental structures durin... The dental papilla(DP)is essential for the development of dentin and pulp.The extensive cellular heterogeneity within the DP is a critical factor underlying the complex and precise formation of dental structures during odontogenesis.However,the critical cell types within human DP that play essential role in tooth development and regeneration remain largely uncharacterized.In this study,we analyzed the heterogeneity of human DP cells using single-cell sequencing and identified Gliomedin(GLDN)+DP stem cells(DPSCs)were a group of progenitors at an early stage of tooth development and play a key role in the development of pulp and dentin.GLDN+DPSCs strategically accumulate in human DP tissue near the interface of the newly formed dentin or pulp.Functional assays demonstrated that GLDN+DPSCs exhibited enhanced self-renewal,migratory capacity,and odontogenic differentiation potential in vitro compared to GLDN-DPSCs.Moreover,GLDN+DPSCs effectively induce the migration and tube formation of endothelial cells,which are essential for tooth development.The ectopic dental pulp regeneration model confirmed that GLDN+DPSCs can regenerate a vascularized dental pulp structure with an odontoblast layer in vivo.Given their functional capabilities,this population of cells has been designated as GLDN+odontogenic stem cells(OSCs).Mechanistically,GLDN is essential for maintaining the phenotype and function of GLDN+OSCs through BMP5 signaling via autocrine and paracrine mechanisms.In conclusion,this study identifies a previously uncharacterized essential subpopulation of OSCs essential for dental pulp development and regeneration. 展开更多
关键词 dental papilla dp dental papilla cell types development dentin pulpthe cellular heterogeneity gliomedin self renewal single cell sequencing
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Wnt3a promotes in situ dentin formation through NKD1-MSX1 axis-mediated odontogenic differentiation of dental pulp stem cells 认领 引用 被引量：1
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作者 Haoran Du Qiong Li +12 位作者 Chenchen Zhou Junji Xu Kang Gao Zixiao Li Yifan Xu Ousheng Liu Bing Li Jianguang Xu Jingsong Wang Hideaki Kagami Xianqi Li Su Chen Jian Zhou 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第1期137-151,共15页
The functional regeneration of the dentin-pulp complex is pivotal for tooth preservation,yet the molecular mechanisms governing odontoblast differentiation remain poorly understood.In the current study,we revealed a d... The functional regeneration of the dentin-pulp complex is pivotal for tooth preservation,yet the molecular mechanisms governing odontoblast differentiation remain poorly understood.In the current study,we revealed a distinct NKD1+ subpopulation exhibiting secretory odontoblast characteristics,which was specifically induced in dental pulp stem cells(DPSCs) by Wnt3a,but not by Wnt5a or Wnt10a through single-cell transcriptomic profiling.We then found that the NKD1+ subpopulation was functional conservation,which were consistently identified in the odontoblast layers of developing tooth germs in both murine and miniature pig models,as well as within the apical open area in human molars.This conserved spatial distribution and co-localization with DSPP strongly indicates that NKD1+ cells were active dentin-secreting odontoblasts.Analysis of gene regulatory networks using SCENIC identified MSX1 as a key transcription factor regulating the specification of NKD1+ lineage.Mechanistically,Wnt3a orchestrates a tripartite cascade:upregulating NKD1/MSX1 expression,triggering NKD1 membrane detachment,and facilitating direct NKD1-MSX1interaction to promote MSX1 nuclear translocation.CUT&Tag analysis demonstrated MSX1 occupancy at promoters of odontogenic regulato rs,esta blishing its necessity for odontogenic gene activation.Murine pulp exposure models validated that Wnt3a-activated NKD1-MSX1 signaling significantly enhances reparative dentin formation.This study delineates an evolutionarily conserved Wnt3aNKD1-MSX1 axis that resolves stem cell heterogeneity into functional odontoblast commitment,providing both mechanistic insights into dentin-pulp regeneration and a foundation for targeted regenerative therapies. 展开更多
关键词 molecular mechanisms Nkd Wnt dental pulp stem cells dpscs Msx secretory odontoblast characteristicswhich Dental pulp stem cells Odontoblast differentiation
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Overexpressing neurogenic differentiation factor 1 in Müller cells improves retinal function after optic nerve crush injury in adult mice 认领 引用 被引量：1
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作者 Liting Zhong Dashuang Yang +5 位作者 Xiu Han Haiyang Cheng Di Xu Wen Li Gong Chen Ying Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3854-3862,共9页
Optic nerve injury leads to axonal degeneration and the death of retinal ganglion cells,which ultimately causes vision loss.Notably,current treatments are limited.In the present study,we explored whether neurogenic di... Optic nerve injury leads to axonal degeneration and the death of retinal ganglion cells,which ultimately causes vision loss.Notably,current treatments are limited.In the present study,we explored whether neurogenic differentiation factor 1(NeuroD1 or ND1)overexpression in retinal Müller cells may repair the retina after optic nerve crush in mice.Adult mice were subjected to optic nerve crush followed by intravitreal AAV-7m8-GFAP-GFP-ND1 virus injection.Immunofluorescent staining,multi-electrode array recording,electroretinogram,and visual behavior tests were then performed to examine retinal and optic nerve structure and retinal function at various post-optic nerve crush and virus injection times.Western blot analysis and quantitative reverse transcription polymerase chain reaction were performed to explore the possible mechanisms.Compared with the control virus,specific overexpression of ND1 in Müller cells greatly improved the light responses of retinal ganglion cells and retinal neurons in optic nerve crush-injured mice as early as 1-2 weeks post-virus injection and lasted for up to 4 weeks.Neuronal survival in the ganglion cell layer and synaptic connections in the inner retina were slightly improved at 2 weeks;however,visual behavior,retinal ganglion cell survival,and optic nerve structure were not improved.ND1 transiently enhanced glial cell-derived neurotrophic factor expression in the optic nerve crush-injured retina but hardly inhibited retinal inflammation within 2 weeks.Together,our data indicate that ND1 overexpression in Müller cells improves retinal function in the optic nerve crush-injured retina,and suggest that its neuroprotective effect may be caused by enhanced glial cell-derived neurotrophic factor release. 展开更多
关键词 glial cell-derived neurotrophic factor inflammation Müller cell NeuroD1 optic nerve injury retinal ganglion cell synaptic connection
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Key Advancements and Emerging Trends of Perovskite Solar Cells in 2024-2025 认领 引用 被引量：2
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作者 Xiangqian Shen Xuesong Lin +15 位作者 Hongzhen Su Ziyang Zhang Tianhao Wu Jing Zhang Yong Peng Yiqiang Zhang Shufang Zhang Zhongmin Zhou Xiangyue Meng Peng Gao Wei Chen Yongzhen Wu Chuanjiang Qin Qifeng Han Yanbo Wang Liyuan Han 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第6期776-808,共33页
The past two years have witnessed remarkable progress in perovskite solar cells(PSCs),marked by breakthroughs in power conversion efficiency and strides in addressing long-term operational stability.At present,the cer... The past two years have witnessed remarkable progress in perovskite solar cells(PSCs),marked by breakthroughs in power conversion efficiency and strides in addressing long-term operational stability.At present,the certified power conversion efficiencies of singlejunction PSCs and silicon/perovskite tandem cells have surpassed 27%and 34%,respectively.Regarding stability,researchers begun to focus their attention on the challenges faced by PSCs when operated in outdoor environments.Furthermore,breakthroughs in the utilization of green solvents,fabrication in ambient air conditions,aqueous-phase synthesis of perovskite raw materials at kilogram scale,vacuum flash evaporation,and machine learning-assisted design are accelerating the commercialization of PSCs.The review summarizes the key advancements of PSCs during 2024-2025.It identifies a critical performance discrepancy between small-area devices and perovskite solar modules and delves into strategies aimed at bridging this gap.Finally,perspectives on the future directions of PSCs are presented,with a particular emphasis on improving photocurrent and environmental sustainability. 展开更多
关键词 Perovskite solar cells Tandem architectures Interface engineering Operational stability Scalable fabrication
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Cancer stem cells in hepatocellular carcinoma:platforms,updates,challenges and future perspectives 认领 引用 被引量：1
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作者 Jingyi Lu Diana Chui-Yee O +1 位作者 Yu-Man Tsui Irene Oi-Lin Ng 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第1期1-7,共7页
Hepatocellular carcinoma(HCC)is a pressing global health problem and is the sixth most common cancer and the third leading cause of cancer mortality worldwide.Despite continuous advances in treatment modalities,the 5-... Hepatocellular carcinoma(HCC)is a pressing global health problem and is the sixth most common cancer and the third leading cause of cancer mortality worldwide.Despite continuous advances in treatment modalities,the 5-year survival rate is low with a high propensity for recurrence and metastasis1.This clinical challenge in treating HCC is largely attributed to the heterogeneity and intrinsic therapy resistance of cancer stem cells(CSCs),which are a subpopulation of cells with self-renewal capability and multidirectional differentiation potential to induce tumorigenicity2.The behavior and maintenance of CSCs are not autonomous but critically dependent on the complex bidirectional crosstalk between CSCs and the tumor immune microenvironment(TIME)1.In this review we first summarize the recent progress in characterizing CSCs and the interactions between CSCs and the TIME in HCC.Next,we discuss the emerging therapeutic strategies targeting CSC populations with the ongoing challenges.Finally,we give our perspectives on the future directions in HCC CSC research. 展开更多
关键词 future perspectives hepatocellular carcinoma cancer stem cells cscs which cancer stem cells challenges therapeutic strategies hepatocellular carcinoma hcc tumor immune microenvironment
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Bone marrow mesenchymal stem cells protect against cerebral amyloid angiopathy by enhancing neutrophil mitocytosis 认领 引用 被引量：3
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作者 Mengyan Hu Haotong Yi +10 位作者 Shisi Wang Xinmei Kang Yuxin Liu Zhiruo Liu Huipeng Huang Qin Qin Liling Yuan Wei Cai Wei Qiu Zhengqi Lu Sanxin Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3178-3186,共9页
Current treatments for cerebral amyloid angiopathy are mainly symptomatic and have limited efficacy,and there is a lack of targeted therapies.Mesenchymal stem cell transplantation improves cognitive and motor function... Current treatments for cerebral amyloid angiopathy are mainly symptomatic and have limited efficacy,and there is a lack of targeted therapies.Mesenchymal stem cell transplantation improves cognitive and motor function in conditions such as Alzheimer’s disease,acute ischemic stroke,and Parkinson’s disease.In addition,mesenchymal stem cell therapy modulates the immune system,reduces neuroinflammation,and improves resolution of brain lesions by cells of the macrophage lineage.Cerebral amyloid angiopathy and Alzheimer’s disease share similar pathologic changes involving amyloid-beta deposition,which contributes to the progression of both diseases and exacerbates cognitive deficits through impaired vascular integrity and neuroinflammation.Therefore,we hypothesized that mesenchymal stem cell therapy could also ameliorate the pathological changes seen in cerebral amyloid angiopathy by modulating the immune response.In this study,we show that bone marrow mesenchymal stem cells have a protective effect in a mouse model of cerebral amyloid angiopathy(Tg-SwDI/B).Bone marrow mesenchymal stem cell treatment improved cognitive function,reduced neuroinflammation,and maintained blood-brain barrier integrity in Tg-SwDI/B mice.Mechanistically,bone marrow mesenchymal stem cell treatment enhanced the expulsion of damaged mitochondria from neutrophils via migrasomes,in a process known as mitocytosis,thereby preserving mitochondrial quality within the neutrophils.Mitochondrial damage in neutrophils leads to cellular injury,including the generation of reactive oxygen species and the formation of neutrophil extracellular traps.Neutrophils activate mitocytosis to promote mitochondrial renewal,which further enhances their own clearance by macrophage lineage cells.Our findings demonstrate that bone marrow mesenchymal stem cells are a promising therapeutic candidate for cerebral amyloid angiopathy,as they play a significant role in migrasome-dependent mitochondrial quality control in neutrophils. 展开更多
关键词 bone marrow mesenchymal stem cell cerebral amyloid angiopathy cognitive decline migrasome mitochondria neutrophil mitocytosis
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Regulatory T cells in neurological disorders and tissue regeneration:Mechanisms of action and therapeutic potentials 认领 引用 被引量：1
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作者 Jing Jie Xiaomin Yao +5 位作者 Hui Deng Yuxiang Zhou Xingyu Jiang Xiu Dai Yumin Yang Pengxiang Yang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第4期1277-1291,共15页
Regulatory T cells,a subset of CD4+T cells,play a critical role in maintaining immune tolerance and tissue homeostasis due to their potent immunosuppressive properties.Recent advances in research have highlighted t... Regulatory T cells,a subset of CD4+T cells,play a critical role in maintaining immune tolerance and tissue homeostasis due to their potent immunosuppressive properties.Recent advances in research have highlighted the important therapeutic potential of Tregs in neurological diseases and tissue repair,emphasizing their multifaceted roles in immune regulation.This review aims to summarize and analyze the mechanisms of action and therapeutic potential of Tregs in relation to neurological diseases and neural regeneration.Beyond their classical immune-regulatory functions,emerging evidence points to non-immune mechanisms of regulatory T cells,particularly their interactions with stem cells and other non-immune cells.These interactions contribute to optimizing the repair microenvironment and promoting tissue repair and nerve regeneration,positioning non-immune pathways as a promising direction for future research.By modulating immune and non-immune cells,including neurons and glia within neural tissues,Tregs have demonstrated remarkable efficacy in enhancing regeneration in the central and peripheral nervous systems.Preclinical studies have revealed that Treg cells interact with neurons,glial cells,and other neural components to mitigate inflammatory damage and support functional recovery.Current mechanistic studies show that Tregs can significantly promote neural repair and functional recovery by regulating inflammatory responses and the local immune microenvironment.However,research on the mechanistic roles of regulatory T cells in other diseases remains limited,highlighting substantial gaps and opportunities for exploration in this field.Laboratory and clinical studies have further advanced the application of regulatory T cells.Technical advances have enabled efficient isolation,ex vivo expansion and functionalization,and adoptive transfer of regulatory T cells,with efficacy validated in animal models.Innovative strategies,including gene editing,cell-free technologies,biomaterial-based recruitment,and in situ delivery have expanded the therapeutic potential of regulatory T cells.Gene editing enables precise functional optimization,while biomaterial and in situ delivery technologies enhance their accumulation and efficacy at target sites.These advancements not only improve the immune-regulatory capacity of regulatory T cells but also significantly enhance their role in tissue repair.By leveraging the pivotal and diverse functions of Tregs in immune modulation and tissue repair,regulatory T cells–based therapies may lead to transformative breakthroughs in the treatment of neurological diseases. 展开更多
关键词 demyelinating diseases gene editing immune regulation immune tolerance neural regeneration neurological diseases non-immune mechanisms regulatory T cells stem cells stroke tissue homeostasis tissue repair
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Interferon regulatory factor 1 enhances T cell differentiation in patients with myasthenia gravis 认领 引用 被引量：1
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作者 Yuebei Luo Yijun Ren +3 位作者 Zeyi Wen Zhaohui Luo Huan Yang Liqun Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3267-3280,共14页
Interferon regulatory factor 1 is involved in many autoimmune conditions and is increased in patients with myasthenia gravis.However,its function in myasthenia gravis remains unclear.Herein,we explored the function of... Interferon regulatory factor 1 is involved in many autoimmune conditions and is increased in patients with myasthenia gravis.However,its function in myasthenia gravis remains unclear.Herein,we explored the function of interferon regulatory factor 1 in myasthenia gravis,with an aim to understand the underlying mechanisms.Patients with myasthenia gravis who had acetylcholine receptor antibodies were included in the study.Peripheral blood lymphocytes were extracted from the included patients,and B lymphocyte subsets were isolated.Next,T and B cells from peripheral blood were co-cultured to explore the interferon regulatory factor 1-related mechanisms in myasthenia gravis.Chromatin immunoprecipitation experiments confirmed an interaction between interferon regulatory factor 1 and the CD180 promoter region.Dual-luciferase reporter gene confirmed the transcriptional activity of interferon regulatory factor 1 on CD180 promoter.In vitro results further indicated that interferon regulatory factor 1 promoted B cell activation and T cell differentiation via the inhibition of CD180.Interferon regulatory factor 1 recruited histone deacetylase 1 to inhibit CD180 transcription.Additionally,histone deacetylase 1 promoted B cell activation and T cell differentiation.Finally,in vitro experiments demonstrated that CD180 inhibited B cell activation and T cell differentiation by inhibiting the Toll-like receptor 4/mitogen-activated protein kinasesuclear factor-kappa B pathway.Collectively,our results suggest that interferon regulatory factor 1 enhances T cell differentiation by recruiting histone deacetylase 1 to block B cell CD180 transcription in myasthenia gravis via the Toll-like receptor 4/mitogen-activated protein kinasesuclear factor-kappa B pathway.Together,these findings indicate the important role of interferon regulatory factor 1 in myasthenia gravis and suggest its molecular mechanisms.They also provide new ideas and targets for diagnosing and treating myasthenia gravis,which will be both scientifically and clinically valuable. 展开更多
关键词 autoimmune condition B cell CD180 histone deacetylase 1 interferon regulatory factor 1 mitogen-activated protein kinase myasthenia gravis nuclear factor-kappa B T cell Toll-like receptor 4
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Extracellular vesicles derived from human amniotic fluid stem cells improve bladder dysfunction in rat model of diabetic atherosclerosis 认领 引用 被引量：1
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作者 Ching-Chung Liang Yi-Hao Lin +3 位作者 Chu-Ya Liang Aileen Ro Yung-Hsin Huang Steven W Shaw 《World Journal of Stem Cells》 SCIE 2026年第1期84-96,共13页
BACKGROUND The incidence of diabetic atherosclerosis(DMA)is increasing worldwide,but its pathogenesis remains incompletely understood.In addition to cardiovascular complications,bladder dysfunction is one of the commo... BACKGROUND The incidence of diabetic atherosclerosis(DMA)is increasing worldwide,but its pathogenesis remains incompletely understood.In addition to cardiovascular complications,bladder dysfunction is one of the common comorbidities associated with DMA but is often refractory to current treatments.AIM To investigate the therapeutic effect of human amniotic fluid stem cell-derived extracellular vesicles(hAFSC-EVs)on the recovery of bladder dysfunction in DMA rats.METHODS Eighty rats were divided into normal control,streptozotocin-induced diabetic rats,diabetic rats subjected to arterial balloon endothelial injury of common iliac artery(DMA),and DMA rats treated with hAFSC-EVs(DMA+hAFSC-EVs).At 4 weeks and 12 weeks after DMA induction,levels of blood glucose,total cholesterol,triglyceride,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,homeostasis model assessment(HOMA)-insulin resistance,and HOMA-βwere measured.Cystometry,common iliac artery wall thickness,and bladder tumor necrosis factor(TNF)-α,interleukin(IL)-6,transforming growth factor(TGF)-β1,Smad3,connective tissue growth factor(CTGF)and fibronectin were also evaluated.RESULTS Bladder weight and blood glucose,triglyceride,HOMA-insulin resistance,common iliac artery intima thickness,voided volume,intercontraction interval,bladder capacity,and mRNA expression of TNF-α,IL-6,TGF-β1,Smad3,CTGF and fibronectin were significantly increased at 4 weeks and 12 weeks after induction,while the HOMA-βlevel decreased at 4 weeks and 12 weeks,and the high-density lipoprotein cholesterol level decreased at 12 weeks.hAFSC-EVs treatment in DMA rats significantly reduced bladder weight and blood glucose,thickness of common iliac arterial intima,voided volume,intercontraction interval and bladder capacity at 4 weeks.The mRNA expression of TNF-α,TGF-β1,and CTGF in DMA rats treated with hAFSC-EVs were significantly decreased at 4 weeks,while the mRNA expressions of IL-6 and Smad3 were significantly decreased 12 weeks.CONCLUSION hAFSC-EVs treatment can help restore DMA-induced bladder dysfunction,which is associated with lowered blood glucose levels,reduced arterial wall thickness,and decreased TNF-α,IL-6,TGF-β1,Smad3,and CTGF expression. 展开更多
关键词 Atherosclerosis Bladder Diabetes Exosome Extracellular vesicles Stem cell
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Dual-timescale crystallization engineering enabling directα-FAPbI3 formation for high-efficiency antisolvent-free perovskite solar cells 认领 引用 被引量：1
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作者 Zhengyan He Zhiqiang Zhang +8 位作者 Yongjia Li Qilin Wei Feng Liu Mingwang Chang Dan Huang Shufang Zhang Liang Wang Qian Liu William W.Yu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第1期891-901,I0020,共11页
FAPbI3 has been extensively employed in high-performance perovskite solar cells(PSCs)owing to its optimal bandgap and outstanding optoelectronic properties.Nevertheless,it readily undergoes the formation of a photo-in... FAPbI3 has been extensively employed in high-performance perovskite solar cells(PSCs)owing to its optimal bandgap and outstanding optoelectronic properties.Nevertheless,it readily undergoes the formation of a photo-inactiveδ-phase during crystallization,and achieving high-qualityα-phase films becomes even more challenging in antisolvent-free fabrication processes.This study introduces a crystallization control strategy based on 2-dimethylaminopyridine(2-DMAP)ligand engineering to establish a“fast nucleation-slow growth”dual-time-domain crystallization mechanism.2-DMAP facilitates the formation of a functional intermediate phase(2-DMAP·PbI2·DMSO)that enables a direct transformation to theα-FAPbI3 phase and effectively suppresses theδ-phase pathway.Theoretical calculations and systematic experimental characterizations demonstrate that 2-DMAP exhibits stronger binding affinity and a greater charge polarization effect than dimethylsulfoxide(DMSO).This promotes the formation of high-density nuclei during spin coating and delays excessive grain growth during annealing,leading to perovskite films with improved crystallinity,fewer defects,and longer carrier lifetimes.As a result,an antisolvent-free PSC device was successfully fabricated,achieving a power conversion efficiency(PCE)of 25.10%,one of the highest reported for antisolvent-free spin-coating systems.Under ISOS-L-1 standard conditions,the device retained 84.78%of its initial efficiency after 1500 h of continuous illumination,demonstrating excellent operational stability.Moreover,it exhibited remarkable long-term stability under harsh humid and thermal conditions.This work offers a valuable strategy for the large-scale fabrication of high-performance and antisolvent-free PSCs. 展开更多
关键词 Perovskite solar cells Crystallization control Antisolvent-free fabrication Phase transformation
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