This Special Topic of the Journal of Semiconductors(JoS)features expanded versions of key articles presented at the 2025 IEEE International Conference on Integrated Circuits Technologies and Applications(ICTA),which w...This Special Topic of the Journal of Semiconductors(JoS)features expanded versions of key articles presented at the 2025 IEEE International Conference on Integrated Circuits Technologies and Applications(ICTA),which was held in Macao,China,from October 22 to 24,2025.IEEE ICTA is an IEEE flagship conference in the field of integrated circuits(IC)in China,which provides a communication platform for sharing the state-of-the-art techniques from experts in the field of ICs.Among the 146 papers presented at ICTA 2025,the Technical Program Committee and the Award Committee have selected 3 high-quality articles for recommending to the Special Topic of JoS,covering the technical fields of RF,medical neural interface,and vision sensing ICs.展开更多
A specialized sympathetic-eosinophil circuit in stress-induced inflammation.Psychological stress is widely recognized as an important aggravating factor in atopic dermatitis(AD)[1],yet the biological pathways that tra...A specialized sympathetic-eosinophil circuit in stress-induced inflammation.Psychological stress is widely recognized as an important aggravating factor in atopic dermatitis(AD)[1],yet the biological pathways that translate central stress perception into peripheral inflammation remain unclear.Tian et al.[2]identified a specialized neuroimmune circuit in which prodynorphin-expressing(Pdyn+)sympathetic neurons regulated eosinophil-mediated skin inflammation under stressful conditions.展开更多
Matchgates and Clifford circuits are two types of quantum circuits which can be efficiently simulated classically,though the underlying reasons are quite different.Matchgates are essentially the single particle basis ...Matchgates and Clifford circuits are two types of quantum circuits which can be efficiently simulated classically,though the underlying reasons are quite different.Matchgates are essentially the single particle basis transformations in the Majorana fermion representation,which can be easily handled classically,while the Clifford circuits can be efficiently simulated using the tableau method according to the Gottesman–Knill theorem.展开更多
To overcome the physical limitations of current quantum hardware in terms of available qubits and connectivity,distributed quantum computing(DQC)has emerged as a promising and scalable paradigm.However,in distributed ...To overcome the physical limitations of current quantum hardware in terms of available qubits and connectivity,distributed quantum computing(DQC)has emerged as a promising and scalable paradigm.However,in distributed settings,cross-node qubit interactions incur high communication overhead due to the use of costly quantum communication protocols.Efficient circuit partitioning and transmission cost optimization have thus become key challenges.This work addresses the often-overlooked issues of hardware heterogeneity and redundant transmission by proposing a resource-aware partitioning and transmission cost optimization method for distributed quantum circuits.First,we develop a partitioning framework constrained by qubit resources,which accommodates node capacity differences to enable flexible qubit allocation.Second,we model gate dependencies using a directed acyclic graph(DAG)representation and introduce formal criteria to detect“initial-state”and“final-state”redundancies.A measurement-reset strategy is then employed to replace part of the quantum communication,reducing inter-node data transmission.Experimental results on a variety of benchmark circuits and heterogeneous architectures demonstrate that our method significantly reduces transmission cost and improves overall resource utilization.These findings offer both theoretical insight and practical guidance for efficient distributed quantum computing.展开更多
After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the tim...After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.展开更多
To achieve the detection of extremely weak signals from pyroelectric infrared detectors and to meet the demands of high-sensitivity applications,this paper proposes a dual-capacitor transimpedance amplifier(CTIA)reado...To achieve the detection of extremely weak signals from pyroelectric infrared detectors and to meet the demands of high-sensitivity applications,this paper proposes a dual-capacitor transimpedance amplifier(CTIA)readout structure featuring a variable array size.Additionally,a bandgap reference and a low dropout regulator(LDO)are designed as the bias circuit to provide voltage bias,in order to meet the requirements of low noise,low power consumption,large dynamic range and portability.The circuit is designed in TSMC 0.18μm 1P6M CMOS process under a 3.3V supply.For the layout implementation,advanced techniques,including dummy structures and guard rings,are employed to improve device matching,overall layout symmetry,as well as the noise immunity and electrical stability of the analog circuitry.展开更多
Multiscale multiphysics simulation is a key technology for nuclear reactor system design and analysis.However,its application and development are limited by the complexity of cross-scale simulation coupling and long c...Multiscale multiphysics simulation is a key technology for nuclear reactor system design and analysis.However,its application and development are limited by the complexity of cross-scale simulation coupling and long calculation times.To satisfy the real-time simulation requirements of modern reactor digital twins,this study establishes a digital twin of the reactor circuit using multiphysics and multiscale reduced-order methods.This digital twin is based on the plug-and-play approach,and all simulations of the components are replaced by independent 1D and 3D multiphysical reduced-order surrogate models.The complete system circuit can be composed of a combination of these surrogate models,which allows for the easy integration of new components and modification of existing components.A digital twin circuit is established for the test case.The reactor core is described using the 3D neutronicshermal-hydraulics model,whereas the steam generator is described using the 3D CFD model.The other components,including the heat and cold pipes,are described using a 1D reduced-order model.The numerical results show that the digital twin can accurately predict the multiphysics and multiscale behavior of the reactor circuit.The maximum relative error of the tested circuit is not larger than 0.05%,and the simulation time can be reduced to less than 2 ms.The proposed plug-and-play digital twin can be used to develop a new real-time digital twin system that can support reactor system design and analysis.展开更多
The advent of SnO2materials has significantly revolutionized semiconductor gas sensors.However,their high working temperature,sluggish responseecovery velocities,poor sensitivities,and baseline drift are still esse...The advent of SnO2materials has significantly revolutionized semiconductor gas sensors.However,their high working temperature,sluggish responseecovery velocities,poor sensitivities,and baseline drift are still essentials factor impeding their applications in advanced sensing devices.Owing to the improved receptor,transducer,and utility factor function,constructing heterostructures substantially enhances the gas-sensitive properties of single material.Although many works on SnO2materials have been summarized in some excellent reviews,a comprehensive overview of SnO2materials from the underlying gas-sensitive mechanisms to material design to applications combined with back-end detection circuits is missing.Herein,a comprehensive review is presented on the state-of-art of SnO2-baesed p-n heterostructures and applications of the combination of back-end detection circuits and devices.The microscopic regulation mechanism of p-n heterojunctions on improved gas-sensitive properties is investigated in depth.Some representative composites are discussed,including SnO2composited with metal oxides,two-dimensional materials,and conductive polymers.Additionally,the particular emphasis is given to the detection circuits used in semiconductor gas sensors.Finally,the current challenges are summarized,and perspectives on future opportunities are presented.This work aims to advance the evolution of high-performance sensitive nanomaterials and detection circuits,and render them promising in miniaturized and integrated gas sensors.展开更多
The modeling and dynamical analysis of discrete chaotic systems is a vital research field,and various chaotic maps have been developed using mathematical and control-theoretic approaches.However,physical circuit desig...The modeling and dynamical analysis of discrete chaotic systems is a vital research field,and various chaotic maps have been developed using mathematical and control-theoretic approaches.However,physical circuit design of mathematically defined discrete chaotic systems and the computation of their energy functions remain challenging and open problems.In this study,a two-dimensional(2D)chaotic map is constructed using an open-loop modulation coupling method,and its dynamical characteristics are analyzed using bifurcation diagrams.Lyapunov exponents(LEs)and spectral entropy(SE)complexity are also inspected under different parameter configurations.Furthermore,the proposed chaotic map is expressed using two distinct physical memristive circuits:one is composed of a magnetic flux-controlled memristor,a nonlinear resistor,and a capacitor;the other utilizes a charge-controlled memristor,a nonlinear resistor,and an inductor.Moreover,two energy functions are derived from the two memristor-coupled circuits for the proposed chaotic map.The results demonstrate that the mathematical model of the discrete chaotic system can be effectively expressed through these two nonlinear circuits.Our study offers a theoretical foundation and viable methodology for the physical circuit representation of discrete chaotic systems and determination of their energy functions.展开更多
Point-of-care diagnostics and inline quantitative phase imaging(QPI)drive the demand for portable,ultra-miniaturized,and robust optical imaging and metrology systems.We propose and demonstrate a wavefront sensor integ...Point-of-care diagnostics and inline quantitative phase imaging(QPI)drive the demand for portable,ultra-miniaturized,and robust optical imaging and metrology systems.We propose and demonstrate a wavefront sensor integrated into a photonic integrated circuit,enabling single-shot optical phase retrieval.We implemented an integrated wavefront sensor array with a spatial resolution of 17μm and a numerical aperture of 0.1.Furthermore,we experimentally demonstrated the reconstruction of wavefronts defined by Zernike polynomials,specifically the first 14 terms(Z1to Z14),achieving an average root mean square error below 0.07.This advancement paves the way for fully integrated,portable,and robust optical imaging systems,facilitating integrated wavefront sensors in demanding applications such as point-of-care diagnostics,endoscopy,in situ QPI,and inline surface profile measurement.展开更多
Coking wastewater(CWW),characterized by complex composition,high toxicity from phenolic compounds(PCs),and recalcitrant chemical oxygen demand(COD),poses significant treatment challenges.This study innovatively repurp...Coking wastewater(CWW),characterized by complex composition,high toxicity from phenolic compounds(PCs),and recalcitrant chemical oxygen demand(COD),poses significant treatment challenges.This study innovatively repurposes printed circuit board sludge(PCBS)as a low-cost heterogeneous catalyst in a Fenton-like advanced oxidation process activated by sodium thiosulfate(STS)for simultaneous removal of PCs and COD.Key parameters(acid-leaching(H2SO4):1.14 mol/L;PCBS dosage:1.34 g/L;STS:0.03 mmol/L;H2O2:79.88 mmol/L)were optimized via Box-Behnken Design response surface methodology.The PCBS/H2O2/STS system exhibited excellent performance in removing PCs and COD from CWW,achieving the model predicts removal efficiencies of 95.51%and 56.32%,respectively,under optimized conditions.Through experimental verification,the experimental removal efficiency of PCs and COD are 95.66%and 57.74%,respectively,with a difference of only 1.42%and 0.15%from the estimated values of the model.The degradation proceeds through a dual-phase mechanism:(1)heterogeneous catalysis on PCBS surfaces,where Fe/Cu species activate H2O2to generate HO•,and(2)homogeneous reactions driven by leached Fe3+/Cu2+ions,which are reduced by STS to Fe2+/Cu+,further reacting with H2O2.Notably,hydroquinone and benzoquinone intermediates act as electron mediators,establishing a self-sustained redox loop that minimizes STS consumption.This‘waste-to-resource’strategy repurposes PCBS as both a catalyst and metal source,while the reduction effect of STS overcomes the limitations of traditional Fenton processes.Overall,the PCBS/H2O2/STS system provides an efficient,sustainable solution for CWW treatment and pollutant degradation.展开更多
Memristor-based neural networks are one of the most promising approaches for the hardware implementation of artificial neural networks.In this paper,a memristor-based neural network circuit based on a one-memristor–o...Memristor-based neural networks are one of the most promising approaches for the hardware implementation of artificial neural networks.In this paper,a memristor-based neural network circuit based on a one-memristor–one-resistor(1M1R)synaptic array structure is designed for character recognition.Compared with other memristive synaptic arrays,the 1M1R structure can reduce the number of memristors used.However,memristors may malfunction due to fabrication defects and the influence of external factors,resulting in a decrease in the accuracy of the circuit's character recognition,and a suitable solution needs to be found to improve the stability and durability of the circuit.Therefore,in this paper,a fault-tolerant module with feedback adjustment capability is designed in the memristive neural network circuit that can readjust the weights of the memristors through in-situ training to solve multiple faults in the memristive neural network.The effect of fault tolerance is verified by character recognition.The experimental results show that the designed memristive neural network circuit can accurately realize character recognition,and the designed fault-tolerant circuit can well tolerate multiple faults,ensuring stable operation of the circuit under fault conditions.展开更多
The mammalian cerebral cortex,despite its variation in brain shape and size,is a stereotypical six-layered structure composed of pyramidal cells,interneurons,astrocytes,microglia,oligodendrocytes,and endothelial cells...The mammalian cerebral cortex,despite its variation in brain shape and size,is a stereotypical six-layered structure composed of pyramidal cells,interneurons,astrocytes,microglia,oligodendrocytes,and endothelial cells.During development,these cells differ in their origin,birth timing,and developmental trajectories.Nonetheless,they converge during development,forming nascent cortical circuits crucial for organismal behavior.While the relative proportions of cortical cells vary between regions.展开更多
Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at th...Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at the molecular,cellular,and neural circuit levels.Abnormal molecular signaling pathways or dysfunction of specific cell types can lead to epilepsy by disrupting the normal functioning of neural circuits.The continuous emergence of new technologies and the rapid advancement of existing ones have facilitated the discovery and comprehensive understanding of the neural circuit mechanisms underlying epilepsy.Therefore,this review aims to investigate the current understanding of the neural circuit mechanisms in epilepsy based on various technologies,including electroencephalography,magnetic resonance imaging,optogenetics,chemogenetics,deep brain stimulation,and brain-computer interfaces.Additionally,this review discusses these mechanisms from three perspectives:structural,synaptic,and transmitter circuits.The findings reveal that the neural circuit mechanisms of epilepsy encompass information transmission among different structures,interactions within the same structure,and the maintenance of homeostasis at the cellular,synaptic,and neurotransmitter levels.These findings offer new insights for investigating the pathophysiological mechanisms of epilepsy and enhancing its clinical diagnosis and treatment.展开更多
Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after inju...Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.展开更多
This paper introduces a quantum lattice Boltzmann method for simulating complex flows.The proposed quantum scheme effectively overcomes the mismatch between the nonlinear collision in the standard lattice Boltzmann me...This paper introduces a quantum lattice Boltzmann method for simulating complex flows.The proposed quantum scheme effectively overcomes the mismatch between the nonlinear collision in the standard lattice Boltzmann method(LBM)and the linear quantum computing(QC)through a linearized non-equilibrium collision operator,and is successfully extended to the Navier-Stokes systems by designing a modular circuit for density and velocity calculations.Most importantly,the present approach ensures the unitary of quantum algorithms while keeping the collision relaxation parameter adjustable for simulating flows with different Reynolds numbers.The accuracy and practicality of the proposed method are demonstrated by simulating two typical flows,including lid-driven and natural convection flows in a square cavity at different Reynolds and Rayleigh numbers,respectively.This work offers a practical application of QC-based LBM for complex fluid dynamics problems.展开更多
Memristive circuits have been widely employed to emulate various neural behavioral mechanisms.However,most existing works remain focused on isolated learning processes and have not yet established behavioral systems c...Memristive circuits have been widely employed to emulate various neural behavioral mechanisms.However,most existing works remain focused on isolated learning processes and have not yet established behavioral systems capable of adapting to changing stimuli,transitioning across perceptual states,and preserving behavioral continuity.To address these limitations,an echolocation-inspired memristive behavioral decision circuit is proposed in this work.The framework is organized into four functional modules—Stimulus,Action,Decision-making,and Memory—which operate cooperatively to enable behavioral generation that transitions from stimulus-driven responses to experience-driven execution across different conditions.Under strong stimulus conditions,behavior is directly elicited by external sensory input;under weak stimulus conditions,decision reliability is maintained through internal regulation;and under no-stimulus conditions,behavioral continuity is preserved through experience-based bias and memory replay.PSPICE simulations verify that the circuit maintains stable decision outputs and functional continuity across all conditions,demonstrating its effectiveness for biologically inspired and adaptive decision-making in neuromorphic systems.展开更多
Bionic circuits can reproduce the firing activities of excitable biological neurons,which are the potential hardware foundation for artificial intelligent applications.This paper builds a meminductive and memristive e...Bionic circuits can reproduce the firing activities of excitable biological neurons,which are the potential hardware foundation for artificial intelligent applications.This paper builds a meminductive and memristive emulator-based bionic circuit by referring to the electrophysiological microstructure of the lipid bilayer membrane of a biological neuron,within which an S-type memristor and a flux-controlled meminductor are employed to characterize the ion channels and their internal electromagnetic induction,respectively.The schematic of the bionic circuit only involves a capacitor,a memristor,a meminductor,and an external direct current(DC)source.Numerical simulations demonstrate that the bionic circuit can generate abundant chaotic and periodic spiking activities for the external stimulus,memristor-,and meminductor-related parameters.Moreover,a printed circuit board(PCB)-based hardware circuit is manually fabricated,upon which experimental measurements are performed to verify the chaotic and periodic spiking activities.This exploration demonstrates the feasibility of the bionic circuit in generating spiking activities and provides a hardware foundation for spike-based applications.展开更多
The hippocampal dorsal CA2 subregion(dCA2)is critical for social memory;however,its contribution to other types of hippocampus-dependent memories is not well understood.Here,we performed dCA2-specific circuit tracing,...The hippocampal dorsal CA2 subregion(dCA2)is critical for social memory;however,its contribution to other types of hippocampus-dependent memories is not well understood.Here,we performed dCA2-specific circuit tracing,single-neuron projectome analysis,photometric Ca2+imaging,and optogenetic manipulations to study the physiological roles of dCA2 neurons and their axon projections in behavioral paradigms for novel object recognition,novel location recognition,and contextual fear memory.We found that dCA2 neurons sent their strongest axon projections to the dorsal portion of ventral CA1(vCA1d)and showed object and location-specific Ca2+responses.Notably,the dCA2-vCA1d projection contributed to the memory formation of object location but not identity.Furthermore,optogenetic inhibition of the dCA2-vCA1d axon terminals reduced fear responses to foot shocks and impaired contextual memory formation.Collectively,our study reveals critical roles of the dCA2-vCA1d circuit in spatial and context-dependent memories,providing new insights into the function of CA2 neurons.展开更多
The automatic synthesis of analog circuits presents significant challenges. Most existing approaches formulate the problem as a single-objective optimization task, overlooking the fact that design specifications for a...The automatic synthesis of analog circuits presents significant challenges. Most existing approaches formulate the problem as a single-objective optimization task, overlooking the fact that design specifications for a given circuit type can vary widely across applications. To address this limitation, we introduce specification-conditioned analog circuit generation, a task that directly generates analog circuits based on stated specifications. The motivation is to find an effective method that leverages existing well-designed circuits to improve automation in analog circuit design. Specifically, we propose CktGen, a simple yet effective variational autoencoder model that maps discretized specifications and circuits into a joint latent space and reconstructs the circuit from that latent vector. Notably, as a single specification may correspond to multiple valid circuits, naively fusing the specification information into a generative model does not capture these one-to-many relationships. To address this, we first decouple the encoding process of circuits and specifications and align their mapped joint latent space. Then, we employ contrastive training with a filter mask to maximize differences between encoded circuits and specifications. Furthermore, classifier guidance along with latent feature alignment promotes the clustering of circuits sharing the same specification, thus avoiding model collapse into trivial one-to-one mappings. By canonicalizing the latent space with respect to the specifications, we can further optimize and search for an optimal circuit that satisfies the valid target specification. We conduct comprehensive experiments on the open circuit benchmark and introduce several metrics to evaluate cross-model consistency in the specification-conditioned circuit generation task. The experimental results demonstrate that CktGen achieves substantial improvements over existing state-of-the-art methods.展开更多
摘要This Special Topic of the Journal of Semiconductors(JoS)features expanded versions of key articles presented at the 2025 IEEE International Conference on Integrated Circuits Technologies and Applications(ICTA),which was held in Macao,China,from October 22 to 24,2025.IEEE ICTA is an IEEE flagship conference in the field of integrated circuits(IC)in China,which provides a communication platform for sharing the state-of-the-art techniques from experts in the field of ICs.Among the 146 papers presented at ICTA 2025,the Technical Program Committee and the Award Committee have selected 3 high-quality articles for recommending to the Special Topic of JoS,covering the technical fields of RF,medical neural interface,and vision sensing ICs.
基金supported by a grant from the National Research Foundation of Korea funded by the Korean government(RS-2024-00409969).
摘要A specialized sympathetic-eosinophil circuit in stress-induced inflammation.Psychological stress is widely recognized as an important aggravating factor in atopic dermatitis(AD)[1],yet the biological pathways that translate central stress perception into peripheral inflammation remain unclear.Tian et al.[2]identified a specialized neuroimmune circuit in which prodynorphin-expressing(Pdyn+)sympathetic neurons regulated eosinophil-mediated skin inflammation under stressful conditions.
基金the support from the National Key Research and Development Program of MOST of China(Grant No.2022YFA1405400)the National Natural Science Foundation of China(Grant Nos.12274290 and 12522406)+2 种基金the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0301902)the support from the Quantum Science and Technology-National Science and Technology Major Project(Grant No.2023ZD0300200)the Fundamental Research Funds for the Central Universities。
摘要Matchgates and Clifford circuits are two types of quantum circuits which can be efficiently simulated classically,though the underlying reasons are quite different.Matchgates are essentially the single particle basis transformations in the Majorana fermion representation,which can be easily handled classically,while the Clifford circuits can be efficiently simulated using the tableau method according to the Gottesman–Knill theorem.
基金upported by the National Natural Science Foundation of China(Grant No.62072259)in part by the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20221411)in part by the Quantum Science Strategic Initiative Project of Guangdong Province,China(Grant No.GDZX2303007)。
摘要To overcome the physical limitations of current quantum hardware in terms of available qubits and connectivity,distributed quantum computing(DQC)has emerged as a promising and scalable paradigm.However,in distributed settings,cross-node qubit interactions incur high communication overhead due to the use of costly quantum communication protocols.Efficient circuit partitioning and transmission cost optimization have thus become key challenges.This work addresses the often-overlooked issues of hardware heterogeneity and redundant transmission by proposing a resource-aware partitioning and transmission cost optimization method for distributed quantum circuits.First,we develop a partitioning framework constrained by qubit resources,which accommodates node capacity differences to enable flexible qubit allocation.Second,we model gate dependencies using a directed acyclic graph(DAG)representation and introduce formal criteria to detect“initial-state”and“final-state”redundancies.A measurement-reset strategy is then employed to replace part of the quantum communication,reducing inter-node data transmission.Experimental results on a variety of benchmark circuits and heterogeneous architectures demonstrate that our method significantly reduces transmission cost and improves overall resource utilization.These findings offer both theoretical insight and practical guidance for efficient distributed quantum computing.
基金supported by the National Key Research and Development Program of China,No.2023YFC3603705(to DX)the National Natural Science Foundation of China,No.82302866(to YZ).
摘要After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.
基金Supported by the National Natural Science Foundation of China(62025405)the National key research and development program in the 14th five year plan(2021YFA1200700)the Zhejiang Provincial Natural Science Foundation of China(LD25F040001).
摘要To achieve the detection of extremely weak signals from pyroelectric infrared detectors and to meet the demands of high-sensitivity applications,this paper proposes a dual-capacitor transimpedance amplifier(CTIA)readout structure featuring a variable array size.Additionally,a bandgap reference and a low dropout regulator(LDO)are designed as the bias circuit to provide voltage bias,in order to meet the requirements of low noise,low power consumption,large dynamic range and portability.The circuit is designed in TSMC 0.18μm 1P6M CMOS process under a 3.3V supply.For the layout implementation,advanced techniques,including dummy structures and guard rings,are employed to improve device matching,overall layout symmetry,as well as the noise immunity and electrical stability of the analog circuitry.
基金supported by the Guangdong Basic and Applied Basic Research Foundation(No.2025A1515011855)the Open Fund of State Key Laboratory of Nuclear Power Safety Technology and Equipment(No.SKL-2024-WT-05)Sun Yat-sen University Key Cultivation Platform Project(No.45000-12251016)。
摘要Multiscale multiphysics simulation is a key technology for nuclear reactor system design and analysis.However,its application and development are limited by the complexity of cross-scale simulation coupling and long calculation times.To satisfy the real-time simulation requirements of modern reactor digital twins,this study establishes a digital twin of the reactor circuit using multiphysics and multiscale reduced-order methods.This digital twin is based on the plug-and-play approach,and all simulations of the components are replaced by independent 1D and 3D multiphysical reduced-order surrogate models.The complete system circuit can be composed of a combination of these surrogate models,which allows for the easy integration of new components and modification of existing components.A digital twin circuit is established for the test case.The reactor core is described using the 3D neutronicshermal-hydraulics model,whereas the steam generator is described using the 3D CFD model.The other components,including the heat and cold pipes,are described using a 1D reduced-order model.The numerical results show that the digital twin can accurately predict the multiphysics and multiscale behavior of the reactor circuit.The maximum relative error of the tested circuit is not larger than 0.05%,and the simulation time can be reduced to less than 2 ms.The proposed plug-and-play digital twin can be used to develop a new real-time digital twin system that can support reactor system design and analysis.
基金supported by the National Natural Science Foundation of China(No.62004051)the Fundamental Research Funds for the Central Universities of China(No.HIT.NSRIF.2020022,No.2022FRFK060010)+2 种基金the China Postdoctoral Science Foundation(No.2020M670909)the Heilongjiang Postdoctoral Science Foundation(No.LBH-Z19017)the National Key Technologies R&D Program of China(No.2019YFA0705203)。
摘要The advent of SnO2materials has significantly revolutionized semiconductor gas sensors.However,their high working temperature,sluggish responseecovery velocities,poor sensitivities,and baseline drift are still essentials factor impeding their applications in advanced sensing devices.Owing to the improved receptor,transducer,and utility factor function,constructing heterostructures substantially enhances the gas-sensitive properties of single material.Although many works on SnO2materials have been summarized in some excellent reviews,a comprehensive overview of SnO2materials from the underlying gas-sensitive mechanisms to material design to applications combined with back-end detection circuits is missing.Herein,a comprehensive review is presented on the state-of-art of SnO2-baesed p-n heterostructures and applications of the combination of back-end detection circuits and devices.The microscopic regulation mechanism of p-n heterojunctions on improved gas-sensitive properties is investigated in depth.Some representative composites are discussed,including SnO2composited with metal oxides,two-dimensional materials,and conductive polymers.Additionally,the particular emphasis is given to the detection circuits used in semiconductor gas sensors.Finally,the current challenges are summarized,and perspectives on future opportunities are presented.This work aims to advance the evolution of high-performance sensitive nanomaterials and detection circuits,and render them promising in miniaturized and integrated gas sensors.
基金supported by the National Natural Science Foundation of China(No.62301416).
摘要The modeling and dynamical analysis of discrete chaotic systems is a vital research field,and various chaotic maps have been developed using mathematical and control-theoretic approaches.However,physical circuit design of mathematically defined discrete chaotic systems and the computation of their energy functions remain challenging and open problems.In this study,a two-dimensional(2D)chaotic map is constructed using an open-loop modulation coupling method,and its dynamical characteristics are analyzed using bifurcation diagrams.Lyapunov exponents(LEs)and spectral entropy(SE)complexity are also inspected under different parameter configurations.Furthermore,the proposed chaotic map is expressed using two distinct physical memristive circuits:one is composed of a magnetic flux-controlled memristor,a nonlinear resistor,and a capacitor;the other utilizes a charge-controlled memristor,a nonlinear resistor,and an inductor.Moreover,two energy functions are derived from the two memristor-coupled circuits for the proposed chaotic map.The results demonstrate that the mathematical model of the discrete chaotic system can be effectively expressed through these two nonlinear circuits.Our study offers a theoretical foundation and viable methodology for the physical circuit representation of discrete chaotic systems and determination of their energy functions.
基金supported by the National Natural Science Foundation of China(Grant Nos.52175509 and 52450158)the National Key Research and Development Program of China(Grant No.2023YFF1500900)+2 种基金the Shenzhen Fundamental Research Program(Grant No.JCYJ20220818100412027)the Guangdong-Hong Kong Technology Cooperation Funding Scheme Category C Platform(Grant No.SGDX20230116093543005)the Innovation Project of Optics Valley Laboratory(Grant No.OVL2023PY003)。
摘要Point-of-care diagnostics and inline quantitative phase imaging(QPI)drive the demand for portable,ultra-miniaturized,and robust optical imaging and metrology systems.We propose and demonstrate a wavefront sensor integrated into a photonic integrated circuit,enabling single-shot optical phase retrieval.We implemented an integrated wavefront sensor array with a spatial resolution of 17μm and a numerical aperture of 0.1.Furthermore,we experimentally demonstrated the reconstruction of wavefronts defined by Zernike polynomials,specifically the first 14 terms(Z1to Z14),achieving an average root mean square error below 0.07.This advancement paves the way for fully integrated,portable,and robust optical imaging systems,facilitating integrated wavefront sensors in demanding applications such as point-of-care diagnostics,endoscopy,in situ QPI,and inline surface profile measurement.
基金supported by the Key Research and Development Program of Henan Province(No.241111320400)Henan Provincial Natural Science Foundation of China(No.242300421649)+4 种基金the Key Research&Development and Promotion of Special Project(Scientific Problem Tackling)of Henan Province(Nos.252102321066 and 222102320102)the Fundamental Research Funds for the Universities of Henan Province(No.NSFRF2502116)China Postdoctoral Science Foundation(No.2023M731170)the Major Science and Technology Special Projects of Henan Province(No.221100320200)the Doctoral Fund Project of Henan Polytechnic University(No.39B2022–39).
摘要Coking wastewater(CWW),characterized by complex composition,high toxicity from phenolic compounds(PCs),and recalcitrant chemical oxygen demand(COD),poses significant treatment challenges.This study innovatively repurposes printed circuit board sludge(PCBS)as a low-cost heterogeneous catalyst in a Fenton-like advanced oxidation process activated by sodium thiosulfate(STS)for simultaneous removal of PCs and COD.Key parameters(acid-leaching(H2SO4):1.14 mol/L;PCBS dosage:1.34 g/L;STS:0.03 mmol/L;H2O2:79.88 mmol/L)were optimized via Box-Behnken Design response surface methodology.The PCBS/H2O2/STS system exhibited excellent performance in removing PCs and COD from CWW,achieving the model predicts removal efficiencies of 95.51%and 56.32%,respectively,under optimized conditions.Through experimental verification,the experimental removal efficiency of PCs and COD are 95.66%and 57.74%,respectively,with a difference of only 1.42%and 0.15%from the estimated values of the model.The degradation proceeds through a dual-phase mechanism:(1)heterogeneous catalysis on PCBS surfaces,where Fe/Cu species activate H2O2to generate HO•,and(2)homogeneous reactions driven by leached Fe3+/Cu2+ions,which are reduced by STS to Fe2+/Cu+,further reacting with H2O2.Notably,hydroquinone and benzoquinone intermediates act as electron mediators,establishing a self-sustained redox loop that minimizes STS consumption.This‘waste-to-resource’strategy repurposes PCBS as both a catalyst and metal source,while the reduction effect of STS overcomes the limitations of traditional Fenton processes.Overall,the PCBS/H2O2/STS system provides an efficient,sustainable solution for CWW treatment and pollutant degradation.
基金supported by the Natural Science Foundation of Shandong Province(Grant No.ZR2022MF225)the National Natural Science Foundation of China(Grant Nos.62176143 and 62371275)。
摘要Memristor-based neural networks are one of the most promising approaches for the hardware implementation of artificial neural networks.In this paper,a memristor-based neural network circuit based on a one-memristor–one-resistor(1M1R)synaptic array structure is designed for character recognition.Compared with other memristive synaptic arrays,the 1M1R structure can reduce the number of memristors used.However,memristors may malfunction due to fabrication defects and the influence of external factors,resulting in a decrease in the accuracy of the circuit's character recognition,and a suitable solution needs to be found to improve the stability and durability of the circuit.Therefore,in this paper,a fault-tolerant module with feedback adjustment capability is designed in the memristive neural network circuit that can readjust the weights of the memristors through in-situ training to solve multiple faults in the memristive neural network.The effect of fault tolerance is verified by character recognition.The experimental results show that the designed memristive neural network circuit can accurately realize character recognition,and the designed fault-tolerant circuit can well tolerate multiple faults,ensuring stable operation of the circuit under fault conditions.
基金supported by the Medical Research Council(MR/T030143/1)grant and the University of Manchester。
摘要The mammalian cerebral cortex,despite its variation in brain shape and size,is a stereotypical six-layered structure composed of pyramidal cells,interneurons,astrocytes,microglia,oligodendrocytes,and endothelial cells.During development,these cells differ in their origin,birth timing,and developmental trajectories.Nonetheless,they converge during development,forming nascent cortical circuits crucial for organismal behavior.While the relative proportions of cortical cells vary between regions.
基金supported by Basic Research Programs of Science and Technology Commission Foundation of Shanxi Province,No.20210302123486(to WJ).
摘要Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at the molecular,cellular,and neural circuit levels.Abnormal molecular signaling pathways or dysfunction of specific cell types can lead to epilepsy by disrupting the normal functioning of neural circuits.The continuous emergence of new technologies and the rapid advancement of existing ones have facilitated the discovery and comprehensive understanding of the neural circuit mechanisms underlying epilepsy.Therefore,this review aims to investigate the current understanding of the neural circuit mechanisms in epilepsy based on various technologies,including electroencephalography,magnetic resonance imaging,optogenetics,chemogenetics,deep brain stimulation,and brain-computer interfaces.Additionally,this review discusses these mechanisms from three perspectives:structural,synaptic,and transmitter circuits.The findings reveal that the neural circuit mechanisms of epilepsy encompass information transmission among different structures,interactions within the same structure,and the maintenance of homeostasis at the cellular,synaptic,and neurotransmitter levels.These findings offer new insights for investigating the pathophysiological mechanisms of epilepsy and enhancing its clinical diagnosis and treatment.
摘要Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.
基金supported by the National Natural Science Foundation of China(Grant No.12172203)Li Ka Shing Foundation STU-GTIIT Joint-research Grant(Grant No.2024LKSFG03).
摘要This paper introduces a quantum lattice Boltzmann method for simulating complex flows.The proposed quantum scheme effectively overcomes the mismatch between the nonlinear collision in the standard lattice Boltzmann method(LBM)and the linear quantum computing(QC)through a linearized non-equilibrium collision operator,and is successfully extended to the Navier-Stokes systems by designing a modular circuit for density and velocity calculations.Most importantly,the present approach ensures the unitary of quantum algorithms while keeping the collision relaxation parameter adjustable for simulating flows with different Reynolds numbers.The accuracy and practicality of the proposed method are demonstrated by simulating two typical flows,including lid-driven and natural convection flows in a square cavity at different Reynolds and Rayleigh numbers,respectively.This work offers a practical application of QC-based LBM for complex fluid dynamics problems.
基金supported by the National Natural Science Foundation of China(Grant No.62571079)the Technological Innovation Projects in the Field of Artificial Intelligence in Liaoning Province(Grant No.2023JH26/10300011)+1 种基金the Basic Scientific Research Projects of the Department of Education of Liaoning Province(Grant No.LJ212410152049)the Liaoning Provincial Science and Technology Plan Joint Project(Grant No.2024-MSLH-033)。
摘要Memristive circuits have been widely employed to emulate various neural behavioral mechanisms.However,most existing works remain focused on isolated learning processes and have not yet established behavioral systems capable of adapting to changing stimuli,transitioning across perceptual states,and preserving behavioral continuity.To address these limitations,an echolocation-inspired memristive behavioral decision circuit is proposed in this work.The framework is organized into four functional modules—Stimulus,Action,Decision-making,and Memory—which operate cooperatively to enable behavioral generation that transitions from stimulus-driven responses to experience-driven execution across different conditions.Under strong stimulus conditions,behavior is directly elicited by external sensory input;under weak stimulus conditions,decision reliability is maintained through internal regulation;and under no-stimulus conditions,behavioral continuity is preserved through experience-based bias and memory replay.PSPICE simulations verify that the circuit maintains stable decision outputs and functional continuity across all conditions,demonstrating its effectiveness for biologically inspired and adaptive decision-making in neuromorphic systems.
基金supported by the National Natural Science Foundation of China(Grant Nos.12572066 and 12172066)the 333 Project of Jiangsu Province+1 种基金the Research and Innovation Project of the Compound Semiconductor Innovation Consortium(Grant No.RIPCSIC202502)the College Students’Innovation and Entrepreneurship Training Program of Changzhou University(Grant No.S202510292080)。
摘要Bionic circuits can reproduce the firing activities of excitable biological neurons,which are the potential hardware foundation for artificial intelligent applications.This paper builds a meminductive and memristive emulator-based bionic circuit by referring to the electrophysiological microstructure of the lipid bilayer membrane of a biological neuron,within which an S-type memristor and a flux-controlled meminductor are employed to characterize the ion channels and their internal electromagnetic induction,respectively.The schematic of the bionic circuit only involves a capacitor,a memristor,a meminductor,and an external direct current(DC)source.Numerical simulations demonstrate that the bionic circuit can generate abundant chaotic and periodic spiking activities for the external stimulus,memristor-,and meminductor-related parameters.Moreover,a printed circuit board(PCB)-based hardware circuit is manually fabricated,upon which experimental measurements are performed to verify the chaotic and periodic spiking activities.This exploration demonstrates the feasibility of the bionic circuit in generating spiking activities and provides a hardware foundation for spike-based applications.
基金supported by STI2030-Major Projects(2022ZD0205000)CAS Project for Young Scientists in Basic Research(YSBR-116)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB1010000)National Key R&D Program of China(2020YFE0205900).
摘要The hippocampal dorsal CA2 subregion(dCA2)is critical for social memory;however,its contribution to other types of hippocampus-dependent memories is not well understood.Here,we performed dCA2-specific circuit tracing,single-neuron projectome analysis,photometric Ca2+imaging,and optogenetic manipulations to study the physiological roles of dCA2 neurons and their axon projections in behavioral paradigms for novel object recognition,novel location recognition,and contextual fear memory.We found that dCA2 neurons sent their strongest axon projections to the dorsal portion of ventral CA1(vCA1d)and showed object and location-specific Ca2+responses.Notably,the dCA2-vCA1d projection contributed to the memory formation of object location but not identity.Furthermore,optogenetic inhibition of the dCA2-vCA1d axon terminals reduced fear responses to foot shocks and impaired contextual memory formation.Collectively,our study reveals critical roles of the dCA2-vCA1d circuit in spatial and context-dependent memories,providing new insights into the function of CA2 neurons.
基金supported by the National Natural Science Foundation of China(62472381 and U2336212)the Fundamental Research Funds for the Central Universities(226-2025-00080)the Fundamental Research Funds for the Zhejiang Provincial Universities(226-2024-00208)。
摘要The automatic synthesis of analog circuits presents significant challenges. Most existing approaches formulate the problem as a single-objective optimization task, overlooking the fact that design specifications for a given circuit type can vary widely across applications. To address this limitation, we introduce specification-conditioned analog circuit generation, a task that directly generates analog circuits based on stated specifications. The motivation is to find an effective method that leverages existing well-designed circuits to improve automation in analog circuit design. Specifically, we propose CktGen, a simple yet effective variational autoencoder model that maps discretized specifications and circuits into a joint latent space and reconstructs the circuit from that latent vector. Notably, as a single specification may correspond to multiple valid circuits, naively fusing the specification information into a generative model does not capture these one-to-many relationships. To address this, we first decouple the encoding process of circuits and specifications and align their mapped joint latent space. Then, we employ contrastive training with a filter mask to maximize differences between encoded circuits and specifications. Furthermore, classifier guidance along with latent feature alignment promotes the clustering of circuits sharing the same specification, thus avoiding model collapse into trivial one-to-one mappings. By canonicalizing the latent space with respect to the specifications, we can further optimize and search for an optimal circuit that satisfies the valid target specification. We conduct comprehensive experiments on the open circuit benchmark and introduce several metrics to evaluate cross-model consistency in the specification-conditioned circuit generation task. The experimental results demonstrate that CktGen achieves substantial improvements over existing state-of-the-art methods.