Waist circumference(WC),which is a simple and effective indicator of central obesity,has been proved to be closely related to many chronic diseases,such as hypertension,diabetes,dyslipidemia,cardiovascular,cerebrovasc...Waist circumference(WC),which is a simple and effective indicator of central obesity,has been proved to be closely related to many chronic diseases,such as hypertension,diabetes,dyslipidemia,cardiovascular,cerebrovascular diseases,and so on[1].展开更多
Obesity,a chronic,complex disease characterized by excess fat deposits,has become a major public health issue worldwide.Epidemiological studies have demonstrated that obesity can result in a greater risk of several ha...Obesity,a chronic,complex disease characterized by excess fat deposits,has become a major public health issue worldwide.Epidemiological studies have demonstrated that obesity can result in a greater risk of several harmful outcomes,such as diabetes mellitus and cardiovascular diseases[1].展开更多
BACKGROUND:This study aims to explore the causal relationship of body weight,body mass index(BMI),and waist circumference (WC) with the risk of cardiac arrest (CA) using two-sample Mendelian randomization (MR).METHODS...BACKGROUND:This study aims to explore the causal relationship of body weight,body mass index(BMI),and waist circumference (WC) with the risk of cardiac arrest (CA) using two-sample Mendelian randomization (MR).METHODS:Data were summarized using genome-wide association studies (GWAS).Twosample MR analyses were performed using the inverse variance weighting (IVW) method,the weighted median method,and the MR-Egger analysis.Heterogeneity test and sensitivity analysis were performed using Cochran’s Q test and the leave-one-out method,respectively.The Steiger test was used to detect reverse causality.Bayesian model-averaged MR was used to identify the most influential risk factors.RESULTS:A total of 13 GWAS data were collected for BMI,body weight and WC.IVW analyses showed a positive correlation of body weight,BMI,and WC with CA (all OR>1 and P<0.05),with MR-Egger and weighted median methods confirming the IVW findings.No horizontal pleiotropy or heterogeneity was observed.Sensitivity analysis indicated that no single nucleotide polymorphism(SNP) caused significant changes in overall causality.Bayesian model-averaged MR was also used to rank causality based on marginal inclusion probability (MIP),and the corresponding modelaveraged causal estimate (MACE) were confirmed,which indicated that WC (GWAS ID:ukb-b-9405)was the highest-ranked risk factor (MIP=0.119,MACE=0.011);its posterior probability was 0.057.A total of 14 sex-specific GWAS data on weight,BMI,and WC were analyzed in relationship with CA,and the MR results showed no significant effects of sex-specific factors.CONCLUSION:Body weight,BMI,and WC are causally associated with an increased risk of CA,with WC identified as the most important risk factor.展开更多
BACKGROUND The association between adiposity parameters and incident hepatocellular carcinoma(HCC)in individuals with nonalcoholic fatty liver disease(NAFLD)is yet to be evaluated.AIM To investigate the risk of HCC ac...BACKGROUND The association between adiposity parameters and incident hepatocellular carcinoma(HCC)in individuals with nonalcoholic fatty liver disease(NAFLD)is yet to be evaluated.AIM To investigate the risk of HCC according to body mass index(BMI)and waist circumference(WC)in people with NAFLD.METHODS This population-based cohort study included Korean National Health Insurance Service examination participants with NAFLD(n=1110773).NAFLD was defined as a fatty liver index of≥30.The risk of HCC was determined by Cox propor-tional hazards regression according to BMI and WC after adjusting for age,sex,health behaviors,income,comorbidities,and WC or BMI.RESULTS HCC was diagnosed in 4773(0.43%)participants during a median follow-up of 10.3 years.A U-shaped association between BMI or WC and HCC was observed,with the highest risk observed in the lowest BMI and WC groups.Compared to normal BMI,the adjusted hazard ratio(aHR)of the underweight BMI group was 2.02[95%confidence interval(CI):1.25-3.28].The lowest risk was found in groups with overweight BMI(aHR=0.67,95%CI:0.60-0.73;reference:normal BMI)and WC:85-89.9/80-84.9 cm for men/women(aHR=0.55,95%CI:0.49-0.63;reference:<80/<75 cm).Subgroup analyses of age,sex,health behaviors,and fatty liver index showed consistent results.CONCLUSION The development of HCC shows a U-shaped relationship with BMI and WC in people with NAFLD,with the highest risk in underweight individuals.展开更多
Background Waist circumference (WC), a proxy measure of central body fat, is a better predictor than overall body fat for cardiovascular risk factors in both adults and children. WC cutoffs have been established in ...Background Waist circumference (WC), a proxy measure of central body fat, is a better predictor than overall body fat for cardiovascular risk factors in both adults and children. WC cutoffs have been established in many countries, but the national WC reference has not been developed in China. Objective To study the distribution of WC in a representative group of Chinese children for establishing Chinese WC cutoff points. Methods Cross-sectional data obtained from 15 mainland provinces and Hong Kong were collected. There were 160 225 children and adolescents aged 7-18 years old in total. The subjects were divided into five regional groups namely costal city, other city, noah rural, south rural, and Hong Kong, for analyzing the distribution of WC. Results A large variation in WC distribution was found among the five groups for both sexes. Coastal city group had the highest P85 WC values consistently from the early school ages to 18-year-old compared with other groups. In contrast, south rural group had P85 values consistently lagged behind not only the city groups but also the north rural group. Hong Kong group had a high P85 WC at early ages, but because of the smaller increments of WC during adolescence, the P85 curve was gradually exceeded by the north rural groups. Catch-up trend was found in the two rural groups since the peak of puberty. These disparities were caused by not only socioeconomic and urban-rural factors but also north-south differences. Because of the regional variation of WC, a "gradient" prevalence of central obesity was prospected among these groups. Comparisons of WC distributions between the Chinese and the U.S.A or Netherlands demonstrated the necessary of setting up China's own WC cutoffs. Sex and age-specific percentiles were obtained and smoothed by using LMS method. Conclusion The data obtained from this study could be used to develop national WC cutoff points for Chinese children and adolescents.展开更多
Objectives To explore the optimal threshold values of waist circumference (WC) for detecting cardiovascular (CV) risk factors among Chinese children and adolescents. Methods Association of WC with CV risk factors ...Objectives To explore the optimal threshold values of waist circumference (WC) for detecting cardiovascular (CV) risk factors among Chinese children and adolescents. Methods Association of WC with CV risk factors was studied among 65 898 children aged 7-18 years whose data were pooled from nine previous studies in China. CV risk factors in this study included hypertension (blood pressure above 95 percentile levels), dyslipidemia (with one or more of the following three indexes: TG ≥ 1.7 mmol/L, TC ≥ 5.18 mmol/L, and HDL-C ≤ 1.04 mmol/L) and elevated glucose level (fasting plasma glucose ≥5.6 mmol/L). Receive-operating characteristic analysis (ROC) and logistic regression were employed to derive optimal age- and sex-specific waist circumference references for predicting CV risk factors. Results A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population, while a remarkable increasing trend occurred from the 90th percentile. The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls, which was at the 90th percentiles for detecting at least two of the above three CV risk factors. In comparison with children with waist circumference below the 75th percentile, the odds ratio of two CV risk factors doubled among children with waist circumference between the 75th and the 90th percentile, and increased by 6 times among children with waist circumference above the 90th percentile. The trend of high blood pressure increasing with waist circumference remained significant after having been stratified by BMI category. Conclusion The 75th and the 90th percentiles of WC are the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents, respectively.展开更多
AIM: To determine the discriminatory performance of fatty liver index (FLI) for non-alcoholic fatty liver disease (NAFLD).METHODS: The data of 5052 subjects aged over 18 years were analyzed. FLI was calculated from bo...AIM: To determine the discriminatory performance of fatty liver index (FLI) for non-alcoholic fatty liver disease (NAFLD).METHODS: The data of 5052 subjects aged over 18 years were analyzed. FLI was calculated from body mass index, waist circumference (WC), triglyceride, and gamma glutamyl transferase data. Logistic regression analysis was conducted to determine the association between FLI and NAFLD. The discriminatory performance of FLI in the diagnosis of NAFLD was evaluated by receiver operating characteristic analysis. Area under the curves (AUCs) and related confidence intervals were estimated. Optimal cutoff points of FLI in the diagnosis of NAFLD were determined based on the maximum values of Youden’s index.RESULTS: The mean age of men and women in the study population were 44.8 ± 16.8 and 43.78 ± 15.43, respectively (P = 0.0216). The prevalence of NAFLD was 40.1% in men and 44.2% in women (P < 0.0017). FLI was strongly associated with NAFLD, so that even a one unit increase in FLI increased the chance of developing NAFLD by 5.8% (OR = 1.058, 95%CI: 1.054-1.063, P < 0.0001). Although FLI showed good performance in the diagnosis of NAFLD (AUC = 0.8656 (95%CI: 0.8548-0.8764), there was no significant difference with regards to WC (AUC = 0.8533, 95%CI: 0.8419-0.8646). The performance of FLI was not significantly different between men (AUC = 0.8648, 95%CI: 0.8505-0.8791) and women (AUC = 0.8682, 95%CI: 0.8513-0.8851). The highest performance with regards to age was related to the 18-39 age group (AUC = 0.8930, 95%CI: 0.8766-0.9093). The optimal cutoff points of FLI were 46.9 in men (sensitivity = 0.8242, specificity = 0.7687, Youden’s index = 0.5929) and 53.8 in women (sensitivity = 0.8233, specificity = 0.7655, Youden’s index = 0.5888).CONCLUSION: Although FLI had acceptable discriminatory power in the diagnosis of NAFLD, WC was a simpler and more accessible index with a similar performance.展开更多
Objective To evaluate the associations of sarcopenia,handgrip strength and calf circumference with cognitive impairment among Chinese older adults.Methods Totally 2,525 older adults were recruited from the Healthy Agi...Objective To evaluate the associations of sarcopenia,handgrip strength and calf circumference with cognitive impairment among Chinese older adults.Methods Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study.Cognitive impairment was assessed by the Chinese Mini-Mental State Examination.Handgrip strength was calculated from the means of the right and left hand values.Calf circumference was measured at the site of maximum circumference of the non-dominant leg.The formula developed by Ishii was used to define sarcopenia.Multiple logistic regression was performed to evaluate the associations of sarcopenia,handgrip strength,and calf circumference with cognitive impairment.Results The prevalence of cognitive impairment was 34.36%.The adjusted odds ratio(OR)for cognitive impairment in individuals with sarcopenia was 2.55[95% confidence interval(95%CI):1.86-3.50].Compared with individuals in the first quartile(Q1)of calf circumference,the adjusted ORs in the second,third,and fourth quartiles(Q2,Q3,and Q4)were 0.75(95% CI:0.58-0.96),0.59(95% CI:0.44-0.79),and 0.62(95% CI:0.45-0.8),respectively.Compared with individuals in Q1 of handgrip strength,the adjusted ORs for Q2,Q3,and Q4 were 0.49(95%CI:0.38-0.62),0.31(95% CI:0.23-0.41),and 0.30(95%CI:0.21-0.44),respectively.Conclusion Sarcopenia,identified by low handgrip strength and low calf circumference,was positively associated with cognitive impairment.展开更多
Objective The aim of this study was to determine whether low calf circumference(CC) could predict nutritional risk and the cutoff values of CC for predicting nutritional risk in hospitalized patients aged ≥ 80 years....Objective The aim of this study was to determine whether low calf circumference(CC) could predict nutritional risk and the cutoff values of CC for predicting nutritional risk in hospitalized patients aged ≥ 80 years.Methods A total of 1,234 consecutive patients aged ≥ 80 years were enrolled in this study.On admission, demographic data, CC, and laboratory parameters were obtained.Patients with Nutritional Risk Screening 2002(NRS-2002) total score ≥ 3 were considered as having nutritional risk.Results CC values were significantly lower in patients with nutritional risk compared to those in patients without nutritional risk [27.00(24.50-31.00) vs.31.00(29.00-33.50], P < 0.001].CC was negatively correlated with age and nutritional risk scores.Logistic regression analysis of nutritional risk revealed that body mass index, albumin level, hemoglobin level, cerebral infarction, neoplasms, and CC(OR, 0.897;95% confidence interval, 0.856-0.941;P < 0.001) were independent impact factors of nutritional risk.Nutritional risk scores increased with a decrease in CC.In men, the best CC cutoff value for predicting nutritional risk according to the NRS-2002 was 29.75 cm.In women, the cutoff value was 28.25 cm.Conclusion CC is a simple, noninvasive, and valid anthropometric measure to predict nutritional risk for hospitalized patients aged ≥ 80 years.展开更多
Objective The aim of this study was to describe changes in waist circumference(WC) and prevalence of abdominal obesity over a period of 10 years among Chinese adults in different socio-economic status(SES). Method...Objective The aim of this study was to describe changes in waist circumference(WC) and prevalence of abdominal obesity over a period of 10 years among Chinese adults in different socio-economic status(SES). Methods Data derived from the China Nutrition and Health Surveillance during 2002 and 2010-2012. We calculated the mean WC and the prevalence of abdominal obesity by gender, place of residence, SES indicators(education, income, and marital status), and body mass index(BMI) categoriesand used pooled t-tests to assess the differences between the two time periods. Results 26.0% of men and 25.3% of women had abdominal obesity in 2010-2012. The age-adjusted mean WC increased by 2.7 cm among men and 2.1 cm among women; the age-adjusted prevalence of abdominal obesity increased by 7.7% among men and 5.3% among women. The rising trends were observed in all subgroups except for a negative growth in high-income women. People living in rural areas with low education and income and with a BMI of 18.5 to 23.9 kg/m^2 had a greater absolute and relative increase in WC. People living in rural areas with low income had a greater relative increase in abdominal obesity. Conclusion The mean WC and prevalence of abdominal obesity among Chinese adults have increased during the past 10 years. Gender differences were noted using various SES indicators.展开更多
Objective This study aimed to analyze the temporal trends and characteristics associated with waist circumference(WC)among elderly Chinese people.Methods We used data from 3,096 adults≥65 years who participated in th...Objective This study aimed to analyze the temporal trends and characteristics associated with waist circumference(WC)among elderly Chinese people.Methods We used data from 3,096 adults≥65 years who participated in the China Health and Nutrition Survey(CHNS),an ongoing cohort study,between 1993 and 2015.We used longitudinal quantile regression models to explore the temporal trends and characteristics associated with WC.Results WC increased gradually among the elderly Chinese population during the survey.The WC curves shifted to the right with wider distributions and lower peaks in men and women.All WC percentile curves shifted upward with similar growth rates in the 25th,50th,and 75th percentiles.The WC means increased from 78 cm to 86 cm during the 22 years of our study.WC significantly increased with age and body mass index and decreased with physical activity(PA).These associations were stronger in the higher percentiles than in the lower percentiles.Conclusions WC is rising among Chinese adults≥65 years.Factors affecting WC in elderly people may have different effects on different percentiles of the WC distribution,and PA was the most important protective factor in the higher percentiles of the WC distribution.Thus,different interventional strategies are needed.展开更多
Objective To study the optimal waist circumference (WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559...Objective To study the optimal waist circumference (WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome (MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China.展开更多
AIM To determine the predictive role of body mass index(BMI) and waist circumference(WC) for diabetes and prediabetes risk in future in total sample as well as in men and women separately. METHODS In a population base...AIM To determine the predictive role of body mass index(BMI) and waist circumference(WC) for diabetes and prediabetes risk in future in total sample as well as in men and women separately. METHODS In a population based cohort study, 1765 with mean ± SD age: 42.32 ± 6.18 healthy participants were followed up from 2003 till 2013(n = 960). Anthropometric and biochemical measures of participants were evaluated regularly during the follow up period. BMI and WC measures at baseline and diabetes and prediabetes status of participants at 2013 were determined. Multivariable logistic regression analysis was used for determining the risk of diabetes and prediabetes considering important potential confounding variables. Receiver operatingcharacteristic curve analysis was conducted to determine the best cut of values of BMI and WC for diabetes and prediabetes. RESULTS At 2013, among participants who had complete data, 45 and 307 people were diabetic and prediabetic, respectively. In final fully adjusted model, BMI value was a significant predictor of diabetes(RR = 1.39, 95%CI: 1.06-1.82 and AUC = 0.68, 95%CI: 0.59-0.75; P < 0.001) however not a significant risk factor for prediabetes. Also, WC was a significant predictor for diabetes(RR = 1.2, 95%CI: 1.05-1.38 and AUC = 0.67, 95%CI: 0.6-0.75) but not significant risk factor for prediabetes. Similar results were observed in both genders.CONCLUSION General and abdominal obesity are significant risk factors for diabetes in future.展开更多
Objective For prevention of obesity in Chinese population, it is necessary to definethe optimal range of healthy weight and the appropriate cut-off points of BMI and waistcircumference for Chinese adults. The Working ...Objective For prevention of obesity in Chinese population, it is necessary to definethe optimal range of healthy weight and the appropriate cut-off points of BMI and waistcircumference for Chinese adults. The Working Group on Obesity in China under the supportof International Life Sciences Institute Focal Point in China organized a meta-analysis on therelation between BMI, waist circumference and risk factors of related chronic diseases (e. g.,high diabetes, diabetes mellitus, and lipoprotein disorders). Methods 13 population studiesin all met the criteria for enrollment, with data of 239 972 adults (20-70 year) surveyed inthe 1990s. Data on waist circumference was available for 111411 persons and data on serumlipids and glucose were available for more than 80 000. The study populations located in21provinces, municipalities and autonomous regions in China's Mainland as well as inTaiwan. Each enrolled study provided data according to a common protocol and uniformformat. The Center for data management in Department of Epidemiology, Fu Wai Hospitalwas responsible for statistical analysis. Results and conclusion The prevalence ofhypertension, diabetes, dyslipidemia and clustering of risk factors all increased withincreasing levels of BMI or waist circumference. BMI at 24 with best sensitivity andspecificity for identification of the risk factors, was recommended as the cut-off point foroverweight, BMI at 28 which may identify the risk factors with specificity around 90 % wasrecommended as the cut-off point for obesity. Waist circumference beyond 85 cm for menand beyond 80 cm for women were recommended as the cut-off points for central obesity.Analysis of population attributable risk percent illustrated that reducing BMI to normalrange (<24) could prevent 45%-50% clustering of risk factors. Treatment of obese persons(BMI≥28)with drugs could prevent 15%-17% clustering of risk factors. The waistcircumference controlled under 85 cm for men and under 80 cm for women, could prevent47%-58% clustering of risk factors. According to these, a classification of overweight andobesity for Chinese adults is recommended.展开更多
Objective Waist circumference, as a brief indicator of visceral obesity, is associated with multi-metabolic disorders and cardiovascular diseases. The present study was aimed to find out the relationship between waist...Objective Waist circumference, as a brief indicator of visceral obesity, is associated with multi-metabolic disorders and cardiovascular diseases. The present study was aimed to find out the relationship between waist circumference and carotid intima media thickness (C-IMT), as well as the best waist circumference cutoff for identifying C-IMT elevation in Chinese male patients with newly-diagnosed diabetes. Methods Five hundred and seventy-eight patients from Department of Endocrinology and Metabolism in Shanghai Sixth People's Hospital affiliated to Shanghai Jiao Tong University were enrolled. Both physical examination (for measurement of waist circumference) and carotid ultrasonography (for measurement of C-IMT) were performed. Results After grouping according to the quartiles of C-IMT, the waist circumference increased across all its quartiles. The waist circumference in 3rd and 4th quartiles (90.7_+9.8 cm and 90.8+9.6 cm) was significant higher than in 1st and 2nd quartiles (P〈0.05). When subjects were divided into 4 groups according to waist circumference, the C-IMT of subjects with waist circumference 90-95 cm was significant higher than that of subjects with waist circumference 85-90 cm and less than 85 cm respectively (P〈0.05). Both spearman and partial correlation analysis showed that C-IMT was positively correlated with waist circumference (P〈0.01). C-IMT was found significantly elevated with the increase of waist circumference. Multiple stepwise regression analysis showed that waist circumference was one of the independent risk factors of C-IMT. After an average of 2.23_+0.85 years follow up, there was a significant elevation of C-IMT in the group with baseline waist circumference over 90 cm P〈0.05), while no significant difference was detected in the group with baseline waist circumference less than 90 cm (P=0.27). Logistic regression showed that baseline waist circumference over 90 cm was associated with a relative risk to C-IMT elevation of 1.132 (95% CI 1.043-1.431, P〈0.05). Conclusion Among newly-diagnosed diabetic male patients, waist circumference over 90 cm not only reflects sub-clinical atherosclerosis in early stage, but also predicts the progression of atherosclerosis.展开更多
Objective This paper aims to study the relationship between body fat and sexual development in Chinese girls with different waist circumference.Methods Six thousand one hundred and fifty six girls aged 6-19 were sampl...Objective This paper aims to study the relationship between body fat and sexual development in Chinese girls with different waist circumference.Methods Six thousand one hundred and fifty six girls aged 6-19 were sampled.Their body weight,height,waist circumference,percentage of body fat and secondary sex characteristics were measured.All the subjects were divided into three groups:low class waist circumference,moderate class waist circumference and high class waist circumference.The menarche percentages were analyzed by using the status method.The menarche ages were analyzed by using the retrospective method.Estimates for mean age at entry into a pubertal stage and menarche were calculated by a probit analysis.Results The incidences of moderate class and high class waist circumstance were 20.94%and 25.27%,respectively.The sexual development of the former was earlier than that of the latter.The percentages of the menarche were detected as high classmoderate classlow class.The menarche ages were expressed as high classmoderate classlow class.Conclusion A close association is found between the waist circumference and sexual development,especially the menarche age.Girls with high class waist circumference are more vulnerable to earlier menarche and excess body fat.It is important to control the occurrence of central obesity through monitoring the change of waist circumference in puberty for girls'health.展开更多
Metric measurement of digitized shapes is commonly applied in optical measuring systems.In this letter,three shape-related factors defined by the authors are used in the construction of amultiple linear regression mod...Metric measurement of digitized shapes is commonly applied in optical measuring systems.In this letter,three shape-related factors defined by the authors are used in the construction of amultiple linear regression model which is utilized to compute the circumference of the convex shapes inmillimeter unit.The model is first built upon the relationship hypothesis and then its adequacy ismathematically validated.The results of applying the developed model to the given number of convexshapes in a finite circumferential length range suggest that,in terms of percent error,the model pre-cision is to satisfaction by being within±4%.The test also shows the model’s robustness against theshape’s orientation anisotropy.展开更多
In the recent decades,obesity rates among children and adolescents,especially males,have increased significantly.This worldwide phenomenon is thought to significantly affect the levels of sex hormones.However,the asso...In the recent decades,obesity rates among children and adolescents,especially males,have increased significantly.This worldwide phenomenon is thought to significantly affect the levels of sex hormones.However,the association between waist circumference(a marker of abdominal obesity)and sex hormone levels in children and adolescents is unknown.In this study,4031 participants aged 6–19 years from the United States National Health and Nutrition Examination Survey(NHANES)in the USA were enrolled in this study.The common confounders of age,race,body mass index,educational level,family income,diabetes,and time of sample collection were also collected.The participants missing any of the above information were excluded from the study.We used multiple linear regression and other multiple statistics to assess the associations between waist circumference and serum testosterone,estradiol,sex hormone-binding globulin(SHBG),free androgen index(FAI),and testosterone/estradiol ratio(T/E2).Waist circumference remained associated with sex hormone levels in children and adolescents after controlling for covariates.As waist circumference increases,testosterone levels in children and adolescents show an overall decline after a brief increase,with the inflection point for waist circumference of 65–66 cm.In addition,waist circumference positively correlates with estradiol levels in male children(β=0.007,95%confidence interval:0.004–0.009).Moreover,circulating SHBG decreases in children and adolescents as waist circumference increases.In conclusion,this study highlighted waist circumference as a vital indicator affecting sex hormone levels in children and adolescents.展开更多
Objective To investigate the appropriate waist circumference(WC)cutoff points for central obesity in the middle-aged and elderly Beijing residents by the metabolic syndrome definition of the International Diabetes Fed...Objective To investigate the appropriate waist circumference(WC)cutoff points for central obesity in the middle-aged and elderly Beijing residents by the metabolic syndrome definition of the International Diabetes Federation(IDF).Methods A total of 2,344 Beijing residents aged≥40 years were investigated.They answered questionnaires,received physical examinations,and underwent plasma glucose and lipid profile measurement.Those non-diabetic subjects underwent a 75g oral glucose tolerance test.All data were analyzed to calculate the appropriate WC cutoff points for central obesity reaching the diagonsis of MS.Results 1)Both in males and females,the triglyceride(TG),systolic blood pressure,diastolic blood pressure and fasting plasma glucose(FPG)increased linearly with WC,and the high density lipoprotein cholesterol(HDL-C)decreased linearly with WC(P<0.05).2)The prevalence of elevated TG,reduced HDL-C,elevated blood pressure,elevated FBG,or≥2 of these factors increased with WC(P<0.05).3)Based on the receiver operating characteristic(ROC)curve analysis and Youden index,the WC values for central obesity and for detecting BMI≥25 kg/m2 were about 90 cm for men and 80 cm for women.4)The odds ratio for the presence of two or more metabolic risk factors increased abruptly in men with WC≥90 cm and in women with WC≥80 cm.Conclusions The appropriate WC cutoff point for central obesity was determined to be 90 cm for men and 80 cm for women in the middle-aged and elderly Beijing residents by the metabolic syndrome definition of IDF.展开更多
In clinical practice, it is challenging to elucidate the location of the lesion in a patient's nervous system that is causing the neurologic symptoms, because lesions are often microscopic and cannot be revealed by c...In clinical practice, it is challenging to elucidate the location of the lesion in a patient's nervous system that is causing the neurologic symptoms, because lesions are often microscopic and cannot be revealed by conventional evaluation methods.展开更多
基金funded by National Health Commission of the People’s Republic of China Medical Reform Major Program:China National Chronic Diseases and Nutrition Surveillance of Adults(2015–2017)(No.201519-B)Public Health Emergency Project Nutrition Health and Healthy Diet Campaign(No.102393220020070000012)。
摘要Waist circumference(WC),which is a simple and effective indicator of central obesity,has been proved to be closely related to many chronic diseases,such as hypertension,diabetes,dyslipidemia,cardiovascular,cerebrovascular diseases,and so on[1].
基金supported in part by the Young Scientists Fund of the National Natural Science Foundation of China(Grant No.82304253).
摘要Obesity,a chronic,complex disease characterized by excess fat deposits,has become a major public health issue worldwide.Epidemiological studies have demonstrated that obesity can result in a greater risk of several harmful outcomes,such as diabetes mellitus and cardiovascular diseases[1].
基金This study is supported by the National Natural Science Foundation of China (No. 82072127)。
摘要BACKGROUND:This study aims to explore the causal relationship of body weight,body mass index(BMI),and waist circumference (WC) with the risk of cardiac arrest (CA) using two-sample Mendelian randomization (MR).METHODS:Data were summarized using genome-wide association studies (GWAS).Twosample MR analyses were performed using the inverse variance weighting (IVW) method,the weighted median method,and the MR-Egger analysis.Heterogeneity test and sensitivity analysis were performed using Cochran’s Q test and the leave-one-out method,respectively.The Steiger test was used to detect reverse causality.Bayesian model-averaged MR was used to identify the most influential risk factors.RESULTS:A total of 13 GWAS data were collected for BMI,body weight and WC.IVW analyses showed a positive correlation of body weight,BMI,and WC with CA (all OR>1 and P<0.05),with MR-Egger and weighted median methods confirming the IVW findings.No horizontal pleiotropy or heterogeneity was observed.Sensitivity analysis indicated that no single nucleotide polymorphism(SNP) caused significant changes in overall causality.Bayesian model-averaged MR was also used to rank causality based on marginal inclusion probability (MIP),and the corresponding modelaveraged causal estimate (MACE) were confirmed,which indicated that WC (GWAS ID:ukb-b-9405)was the highest-ranked risk factor (MIP=0.119,MACE=0.011);its posterior probability was 0.057.A total of 14 sex-specific GWAS data on weight,BMI,and WC were analyzed in relationship with CA,and the MR results showed no significant effects of sex-specific factors.CONCLUSION:Body weight,BMI,and WC are causally associated with an increased risk of CA,with WC identified as the most important risk factor.
摘要BACKGROUND The association between adiposity parameters and incident hepatocellular carcinoma(HCC)in individuals with nonalcoholic fatty liver disease(NAFLD)is yet to be evaluated.AIM To investigate the risk of HCC according to body mass index(BMI)and waist circumference(WC)in people with NAFLD.METHODS This population-based cohort study included Korean National Health Insurance Service examination participants with NAFLD(n=1110773).NAFLD was defined as a fatty liver index of≥30.The risk of HCC was determined by Cox propor-tional hazards regression according to BMI and WC after adjusting for age,sex,health behaviors,income,comorbidities,and WC or BMI.RESULTS HCC was diagnosed in 4773(0.43%)participants during a median follow-up of 10.3 years.A U-shaped association between BMI or WC and HCC was observed,with the highest risk observed in the lowest BMI and WC groups.Compared to normal BMI,the adjusted hazard ratio(aHR)of the underweight BMI group was 2.02[95%confidence interval(CI):1.25-3.28].The lowest risk was found in groups with overweight BMI(aHR=0.67,95%CI:0.60-0.73;reference:normal BMI)and WC:85-89.9/80-84.9 cm for men/women(aHR=0.55,95%CI:0.49-0.63;reference:<80/<75 cm).Subgroup analyses of age,sex,health behaviors,and fatty liver index showed consistent results.CONCLUSION The development of HCC shows a U-shaped relationship with BMI and WC in people with NAFLD,with the highest risk in underweight individuals.
基金Funded by International Life Sciences Institute,Focal Point in China.
摘要Background Waist circumference (WC), a proxy measure of central body fat, is a better predictor than overall body fat for cardiovascular risk factors in both adults and children. WC cutoffs have been established in many countries, but the national WC reference has not been developed in China. Objective To study the distribution of WC in a representative group of Chinese children for establishing Chinese WC cutoff points. Methods Cross-sectional data obtained from 15 mainland provinces and Hong Kong were collected. There were 160 225 children and adolescents aged 7-18 years old in total. The subjects were divided into five regional groups namely costal city, other city, noah rural, south rural, and Hong Kong, for analyzing the distribution of WC. Results A large variation in WC distribution was found among the five groups for both sexes. Coastal city group had the highest P85 WC values consistently from the early school ages to 18-year-old compared with other groups. In contrast, south rural group had P85 values consistently lagged behind not only the city groups but also the north rural group. Hong Kong group had a high P85 WC at early ages, but because of the smaller increments of WC during adolescence, the P85 curve was gradually exceeded by the north rural groups. Catch-up trend was found in the two rural groups since the peak of puberty. These disparities were caused by not only socioeconomic and urban-rural factors but also north-south differences. Because of the regional variation of WC, a "gradient" prevalence of central obesity was prospected among these groups. Comparisons of WC distributions between the Chinese and the U.S.A or Netherlands demonstrated the necessary of setting up China's own WC cutoffs. Sex and age-specific percentiles were obtained and smoothed by using LMS method. Conclusion The data obtained from this study could be used to develop national WC cutoff points for Chinese children and adolescents.
基金This research was pooled from nine previous studies which were supported by the Ministry of Health and Ministry of Science and Technology in China (2001DEA30035, 2003DIA6N08)Department of Paediatrics, the Chinese University of Hong Kong and Hong Kong Paediatric Society (grant H030930030130)+3 种基金Beijing Municipal Science and Technology Commission (Y043204, NSFC30500419)Program for New Century Excellent Talents in University of China 2005, Chongqing Health Bureau (07-2-156)State Sport General Administration (06134)the Eleventh Five-Year Plan of Beijing’s Haidian District, and European Nutricia Fund.
摘要Objectives To explore the optimal threshold values of waist circumference (WC) for detecting cardiovascular (CV) risk factors among Chinese children and adolescents. Methods Association of WC with CV risk factors was studied among 65 898 children aged 7-18 years whose data were pooled from nine previous studies in China. CV risk factors in this study included hypertension (blood pressure above 95 percentile levels), dyslipidemia (with one or more of the following three indexes: TG ≥ 1.7 mmol/L, TC ≥ 5.18 mmol/L, and HDL-C ≤ 1.04 mmol/L) and elevated glucose level (fasting plasma glucose ≥5.6 mmol/L). Receive-operating characteristic analysis (ROC) and logistic regression were employed to derive optimal age- and sex-specific waist circumference references for predicting CV risk factors. Results A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population, while a remarkable increasing trend occurred from the 90th percentile. The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls, which was at the 90th percentiles for detecting at least two of the above three CV risk factors. In comparison with children with waist circumference below the 75th percentile, the odds ratio of two CV risk factors doubled among children with waist circumference between the 75th and the 90th percentile, and increased by 6 times among children with waist circumference above the 90th percentile. The trend of high blood pressure increasing with waist circumference remained significant after having been stratified by BMI category. Conclusion The 75th and the 90th percentiles of WC are the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents, respectively.
基金Supported by GILDRCIran University of Medical Sciences
摘要AIM: To determine the discriminatory performance of fatty liver index (FLI) for non-alcoholic fatty liver disease (NAFLD).METHODS: The data of 5052 subjects aged over 18 years were analyzed. FLI was calculated from body mass index, waist circumference (WC), triglyceride, and gamma glutamyl transferase data. Logistic regression analysis was conducted to determine the association between FLI and NAFLD. The discriminatory performance of FLI in the diagnosis of NAFLD was evaluated by receiver operating characteristic analysis. Area under the curves (AUCs) and related confidence intervals were estimated. Optimal cutoff points of FLI in the diagnosis of NAFLD were determined based on the maximum values of Youden’s index.RESULTS: The mean age of men and women in the study population were 44.8 ± 16.8 and 43.78 ± 15.43, respectively (P = 0.0216). The prevalence of NAFLD was 40.1% in men and 44.2% in women (P < 0.0017). FLI was strongly associated with NAFLD, so that even a one unit increase in FLI increased the chance of developing NAFLD by 5.8% (OR = 1.058, 95%CI: 1.054-1.063, P < 0.0001). Although FLI showed good performance in the diagnosis of NAFLD (AUC = 0.8656 (95%CI: 0.8548-0.8764), there was no significant difference with regards to WC (AUC = 0.8533, 95%CI: 0.8419-0.8646). The performance of FLI was not significantly different between men (AUC = 0.8648, 95%CI: 0.8505-0.8791) and women (AUC = 0.8682, 95%CI: 0.8513-0.8851). The highest performance with regards to age was related to the 18-39 age group (AUC = 0.8930, 95%CI: 0.8766-0.9093). The optimal cutoff points of FLI were 46.9 in men (sensitivity = 0.8242, specificity = 0.7687, Youden’s index = 0.5929) and 53.8 in women (sensitivity = 0.8233, specificity = 0.7655, Youden’s index = 0.5888).CONCLUSION: Although FLI had acceptable discriminatory power in the diagnosis of NAFLD, WC was a simpler and more accessible index with a similar performance.
基金supported by National Natural Science Foundation of China[82025030,81941023,81872707,81273160 and 81573247]National Science and Technology Planning Project[2018YFC2000300]NIH/NIA P30AG028716。
摘要Objective To evaluate the associations of sarcopenia,handgrip strength and calf circumference with cognitive impairment among Chinese older adults.Methods Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study.Cognitive impairment was assessed by the Chinese Mini-Mental State Examination.Handgrip strength was calculated from the means of the right and left hand values.Calf circumference was measured at the site of maximum circumference of the non-dominant leg.The formula developed by Ishii was used to define sarcopenia.Multiple logistic regression was performed to evaluate the associations of sarcopenia,handgrip strength,and calf circumference with cognitive impairment.Results The prevalence of cognitive impairment was 34.36%.The adjusted odds ratio(OR)for cognitive impairment in individuals with sarcopenia was 2.55[95% confidence interval(95%CI):1.86-3.50].Compared with individuals in the first quartile(Q1)of calf circumference,the adjusted ORs in the second,third,and fourth quartiles(Q2,Q3,and Q4)were 0.75(95% CI:0.58-0.96),0.59(95% CI:0.44-0.79),and 0.62(95% CI:0.45-0.8),respectively.Compared with individuals in Q1 of handgrip strength,the adjusted ORs for Q2,Q3,and Q4 were 0.49(95%CI:0.38-0.62),0.31(95% CI:0.23-0.41),and 0.30(95%CI:0.21-0.44),respectively.Conclusion Sarcopenia,identified by low handgrip strength and low calf circumference,was positively associated with cognitive impairment.
摘要Objective The aim of this study was to determine whether low calf circumference(CC) could predict nutritional risk and the cutoff values of CC for predicting nutritional risk in hospitalized patients aged ≥ 80 years.Methods A total of 1,234 consecutive patients aged ≥ 80 years were enrolled in this study.On admission, demographic data, CC, and laboratory parameters were obtained.Patients with Nutritional Risk Screening 2002(NRS-2002) total score ≥ 3 were considered as having nutritional risk.Results CC values were significantly lower in patients with nutritional risk compared to those in patients without nutritional risk [27.00(24.50-31.00) vs.31.00(29.00-33.50], P < 0.001].CC was negatively correlated with age and nutritional risk scores.Logistic regression analysis of nutritional risk revealed that body mass index, albumin level, hemoglobin level, cerebral infarction, neoplasms, and CC(OR, 0.897;95% confidence interval, 0.856-0.941;P < 0.001) were independent impact factors of nutritional risk.Nutritional risk scores increased with a decrease in CC.In men, the best CC cutoff value for predicting nutritional risk according to the NRS-2002 was 29.75 cm.In women, the cutoff value was 28.25 cm.Conclusion CC is a simple, noninvasive, and valid anthropometric measure to predict nutritional risk for hospitalized patients aged ≥ 80 years.
基金supported by the National Health and Family Planning Commission(former Ministry of Health of the People's Republic of China)Medical Reform Major Program:China Nutrition and Health Surveillance(2010-2012)
摘要Objective The aim of this study was to describe changes in waist circumference(WC) and prevalence of abdominal obesity over a period of 10 years among Chinese adults in different socio-economic status(SES). Methods Data derived from the China Nutrition and Health Surveillance during 2002 and 2010-2012. We calculated the mean WC and the prevalence of abdominal obesity by gender, place of residence, SES indicators(education, income, and marital status), and body mass index(BMI) categoriesand used pooled t-tests to assess the differences between the two time periods. Results 26.0% of men and 25.3% of women had abdominal obesity in 2010-2012. The age-adjusted mean WC increased by 2.7 cm among men and 2.1 cm among women; the age-adjusted prevalence of abdominal obesity increased by 7.7% among men and 5.3% among women. The rising trends were observed in all subgroups except for a negative growth in high-income women. People living in rural areas with low education and income and with a BMI of 18.5 to 23.9 kg/m^2 had a greater absolute and relative increase in WC. People living in rural areas with low income had a greater relative increase in abdominal obesity. Conclusion The mean WC and prevalence of abdominal obesity among Chinese adults have increased during the past 10 years. Gender differences were noted using various SES indicators.
基金Nutrition and Health, Chinese Center for Disease Control and Prevention, Carolina Population Center, the University of North Carolina at Chapel Hill [5 R24 HD050924]the National Institutes of Health [R01-HD30880, DK056350, R24 HD050924, and R01-HD38700]+1 种基金the Chinese Institute of Food Science and Technology [2020-09]the National Natural Science Foundation of China [No.82103848].
摘要Objective This study aimed to analyze the temporal trends and characteristics associated with waist circumference(WC)among elderly Chinese people.Methods We used data from 3,096 adults≥65 years who participated in the China Health and Nutrition Survey(CHNS),an ongoing cohort study,between 1993 and 2015.We used longitudinal quantile regression models to explore the temporal trends and characteristics associated with WC.Results WC increased gradually among the elderly Chinese population during the survey.The WC curves shifted to the right with wider distributions and lower peaks in men and women.All WC percentile curves shifted upward with similar growth rates in the 25th,50th,and 75th percentiles.The WC means increased from 78 cm to 86 cm during the 22 years of our study.WC significantly increased with age and body mass index and decreased with physical activity(PA).These associations were stronger in the higher percentiles than in the lower percentiles.Conclusions WC is rising among Chinese adults≥65 years.Factors affecting WC in elderly people may have different effects on different percentiles of the WC distribution,and PA was the most important protective factor in the higher percentiles of the WC distribution.Thus,different interventional strategies are needed.
基金supported by the National Natural Science Foundation of China(No.81100617)the Medical and Health Science and Technology Development Projects of Shandong Province(2011HD005)+4 种基金the National Science and Technology Support Plan(2009BAI80B04)the Natural Science Foundation of Shandong Province(ZR2012HM014)the International Science and Technology Projects of Shandong Province(2010GHZ20201,2012GGE27126)the Business Plan of Jinan Students Studying Abroad(20110407)the special scientific research fund of clinical medicine of Chinese Medical Association(12030420342)
摘要Objective To study the optimal waist circumference (WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome (MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China.
摘要AIM To determine the predictive role of body mass index(BMI) and waist circumference(WC) for diabetes and prediabetes risk in future in total sample as well as in men and women separately. METHODS In a population based cohort study, 1765 with mean ± SD age: 42.32 ± 6.18 healthy participants were followed up from 2003 till 2013(n = 960). Anthropometric and biochemical measures of participants were evaluated regularly during the follow up period. BMI and WC measures at baseline and diabetes and prediabetes status of participants at 2013 were determined. Multivariable logistic regression analysis was used for determining the risk of diabetes and prediabetes considering important potential confounding variables. Receiver operatingcharacteristic curve analysis was conducted to determine the best cut of values of BMI and WC for diabetes and prediabetes. RESULTS At 2013, among participants who had complete data, 45 and 307 people were diabetic and prediabetic, respectively. In final fully adjusted model, BMI value was a significant predictor of diabetes(RR = 1.39, 95%CI: 1.06-1.82 and AUC = 0.68, 95%CI: 0.59-0.75; P < 0.001) however not a significant risk factor for prediabetes. Also, WC was a significant predictor for diabetes(RR = 1.2, 95%CI: 1.05-1.38 and AUC = 0.67, 95%CI: 0.6-0.75) but not significant risk factor for prediabetes. Similar results were observed in both genders.CONCLUSION General and abdominal obesity are significant risk factors for diabetes in future.
摘要Objective For prevention of obesity in Chinese population, it is necessary to definethe optimal range of healthy weight and the appropriate cut-off points of BMI and waistcircumference for Chinese adults. The Working Group on Obesity in China under the supportof International Life Sciences Institute Focal Point in China organized a meta-analysis on therelation between BMI, waist circumference and risk factors of related chronic diseases (e. g.,high diabetes, diabetes mellitus, and lipoprotein disorders). Methods 13 population studiesin all met the criteria for enrollment, with data of 239 972 adults (20-70 year) surveyed inthe 1990s. Data on waist circumference was available for 111411 persons and data on serumlipids and glucose were available for more than 80 000. The study populations located in21provinces, municipalities and autonomous regions in China's Mainland as well as inTaiwan. Each enrolled study provided data according to a common protocol and uniformformat. The Center for data management in Department of Epidemiology, Fu Wai Hospitalwas responsible for statistical analysis. Results and conclusion The prevalence ofhypertension, diabetes, dyslipidemia and clustering of risk factors all increased withincreasing levels of BMI or waist circumference. BMI at 24 with best sensitivity andspecificity for identification of the risk factors, was recommended as the cut-off point foroverweight, BMI at 28 which may identify the risk factors with specificity around 90 % wasrecommended as the cut-off point for obesity. Waist circumference beyond 85 cm for menand beyond 80 cm for women were recommended as the cut-off points for central obesity.Analysis of population attributable risk percent illustrated that reducing BMI to normalrange (<24) could prevent 45%-50% clustering of risk factors. Treatment of obese persons(BMI≥28)with drugs could prevent 15%-17% clustering of risk factors. The waistcircumference controlled under 85 cm for men and under 80 cm for women, could prevent47%-58% clustering of risk factors. According to these, a classification of overweight andobesity for Chinese adults is recommended.
基金funded by National Key Technology R&D Program of China(2012BAI02B03)Key Discipline of Public Health of Shanghai(Epidemiology)(12GWZX0104)
摘要Objective Waist circumference, as a brief indicator of visceral obesity, is associated with multi-metabolic disorders and cardiovascular diseases. The present study was aimed to find out the relationship between waist circumference and carotid intima media thickness (C-IMT), as well as the best waist circumference cutoff for identifying C-IMT elevation in Chinese male patients with newly-diagnosed diabetes. Methods Five hundred and seventy-eight patients from Department of Endocrinology and Metabolism in Shanghai Sixth People's Hospital affiliated to Shanghai Jiao Tong University were enrolled. Both physical examination (for measurement of waist circumference) and carotid ultrasonography (for measurement of C-IMT) were performed. Results After grouping according to the quartiles of C-IMT, the waist circumference increased across all its quartiles. The waist circumference in 3rd and 4th quartiles (90.7_+9.8 cm and 90.8+9.6 cm) was significant higher than in 1st and 2nd quartiles (P〈0.05). When subjects were divided into 4 groups according to waist circumference, the C-IMT of subjects with waist circumference 90-95 cm was significant higher than that of subjects with waist circumference 85-90 cm and less than 85 cm respectively (P〈0.05). Both spearman and partial correlation analysis showed that C-IMT was positively correlated with waist circumference (P〈0.01). C-IMT was found significantly elevated with the increase of waist circumference. Multiple stepwise regression analysis showed that waist circumference was one of the independent risk factors of C-IMT. After an average of 2.23_+0.85 years follow up, there was a significant elevation of C-IMT in the group with baseline waist circumference over 90 cm P〈0.05), while no significant difference was detected in the group with baseline waist circumference less than 90 cm (P=0.27). Logistic regression showed that baseline waist circumference over 90 cm was associated with a relative risk to C-IMT elevation of 1.132 (95% CI 1.043-1.431, P〈0.05). Conclusion Among newly-diagnosed diabetic male patients, waist circumference over 90 cm not only reflects sub-clinical atherosclerosis in early stage, but also predicts the progression of atherosclerosis.
基金supported by the Research Fund from the Natural Science Foundation of China(30972495)
摘要Objective This paper aims to study the relationship between body fat and sexual development in Chinese girls with different waist circumference.Methods Six thousand one hundred and fifty six girls aged 6-19 were sampled.Their body weight,height,waist circumference,percentage of body fat and secondary sex characteristics were measured.All the subjects were divided into three groups:low class waist circumference,moderate class waist circumference and high class waist circumference.The menarche percentages were analyzed by using the status method.The menarche ages were analyzed by using the retrospective method.Estimates for mean age at entry into a pubertal stage and menarche were calculated by a probit analysis.Results The incidences of moderate class and high class waist circumstance were 20.94%and 25.27%,respectively.The sexual development of the former was earlier than that of the latter.The percentages of the menarche were detected as high classmoderate classlow class.The menarche ages were expressed as high classmoderate classlow class.Conclusion A close association is found between the waist circumference and sexual development,especially the menarche age.Girls with high class waist circumference are more vulnerable to earlier menarche and excess body fat.It is important to control the occurrence of central obesity through monitoring the change of waist circumference in puberty for girls'health.
基金the Ningbo Natural Science Foundation(No.2006A610016)the Foundation of National EducationMinistry for Returned Overseas Students&Scholars(SRFfor ROCS,SEM.No.2006699).
摘要Metric measurement of digitized shapes is commonly applied in optical measuring systems.In this letter,three shape-related factors defined by the authors are used in the construction of amultiple linear regression model which is utilized to compute the circumference of the convex shapes inmillimeter unit.The model is first built upon the relationship hypothesis and then its adequacy ismathematically validated.The results of applying the developed model to the given number of convexshapes in a finite circumferential length range suggest that,in terms of percent error,the model pre-cision is to satisfaction by being within±4%.The test also shows the model’s robustness against theshape’s orientation anisotropy.
摘要In the recent decades,obesity rates among children and adolescents,especially males,have increased significantly.This worldwide phenomenon is thought to significantly affect the levels of sex hormones.However,the association between waist circumference(a marker of abdominal obesity)and sex hormone levels in children and adolescents is unknown.In this study,4031 participants aged 6–19 years from the United States National Health and Nutrition Examination Survey(NHANES)in the USA were enrolled in this study.The common confounders of age,race,body mass index,educational level,family income,diabetes,and time of sample collection were also collected.The participants missing any of the above information were excluded from the study.We used multiple linear regression and other multiple statistics to assess the associations between waist circumference and serum testosterone,estradiol,sex hormone-binding globulin(SHBG),free androgen index(FAI),and testosterone/estradiol ratio(T/E2).Waist circumference remained associated with sex hormone levels in children and adolescents after controlling for covariates.As waist circumference increases,testosterone levels in children and adolescents show an overall decline after a brief increase,with the inflection point for waist circumference of 65–66 cm.In addition,waist circumference positively correlates with estradiol levels in male children(β=0.007,95%confidence interval:0.004–0.009).Moreover,circulating SHBG decreases in children and adolescents as waist circumference increases.In conclusion,this study highlighted waist circumference as a vital indicator affecting sex hormone levels in children and adolescents.
基金This study was sppored by grant from the Capital Medical Developmcnt Foundation of Bejing(No.2010-1009)
摘要Objective To investigate the appropriate waist circumference(WC)cutoff points for central obesity in the middle-aged and elderly Beijing residents by the metabolic syndrome definition of the International Diabetes Federation(IDF).Methods A total of 2,344 Beijing residents aged≥40 years were investigated.They answered questionnaires,received physical examinations,and underwent plasma glucose and lipid profile measurement.Those non-diabetic subjects underwent a 75g oral glucose tolerance test.All data were analyzed to calculate the appropriate WC cutoff points for central obesity reaching the diagonsis of MS.Results 1)Both in males and females,the triglyceride(TG),systolic blood pressure,diastolic blood pressure and fasting plasma glucose(FPG)increased linearly with WC,and the high density lipoprotein cholesterol(HDL-C)decreased linearly with WC(P<0.05).2)The prevalence of elevated TG,reduced HDL-C,elevated blood pressure,elevated FBG,or≥2 of these factors increased with WC(P<0.05).3)Based on the receiver operating characteristic(ROC)curve analysis and Youden index,the WC values for central obesity and for detecting BMI≥25 kg/m2 were about 90 cm for men and 80 cm for women.4)The odds ratio for the presence of two or more metabolic risk factors increased abruptly in men with WC≥90 cm and in women with WC≥80 cm.Conclusions The appropriate WC cutoff point for central obesity was determined to be 90 cm for men and 80 cm for women in the middle-aged and elderly Beijing residents by the metabolic syndrome definition of IDF.
摘要In clinical practice, it is challenging to elucidate the location of the lesion in a patient's nervous system that is causing the neurologic symptoms, because lesions are often microscopic and cannot be revealed by conventional evaluation methods.