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Genetic elastic fiber disorders as neurovascular syndromes:An emerging perspective 认领 引用
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作者 Francesc Jiménez-Altayó 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期4261-4262,共2页
Genetic elastic fiber diseases arise from inherited or de novo mutations in genes encoding elastic fiber components,such as elastin,fibrillin-1,and associated proteins,leading to abnormalities in their deposition,stru... Genetic elastic fiber diseases arise from inherited or de novo mutations in genes encoding elastic fiber components,such as elastin,fibrillin-1,and associated proteins,leading to abnormalities in their deposition,structure,or degradation(Heinz,2021).Histo rically,research has focused on systemic,non-neurological manifestations,which are more clinically apparent and often life-threatening,particularly cardiovascular complications.In contrast,potential involvement of the central nervous system(CNS) has received limited attention,even though the brain and spinal cord are richly vascula rized structu res,extensively perfused,and critically dependent on the integrity of their blood vessels. 展开更多
关键词 elastic fiber componentssuch genetic elastic fiber diseases central nervous system elastin genetic elastic fiber disorders vasculature fibrillin central nervous system cns
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A novel current-source management integrated circuit applied to high-voltage integrated gate commutated thyristor gate driver 认领 引用
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作者 Shiping Chen Zhanqing Yu +4 位作者 Jiaxu Shi Zhengyu Chen Lu Qu Jinpeng Wu Rong Zeng 《High Voltage》 SCIE EI CSCD 2025年第3期533-545,共13页
This paper presents a fully customised integrated gate commutated thyristor(IGCT)gate driver monolithic integrated circuit(GDMIC),aiming to address the many shortcomings of traditional IGCT gate driver units composed ... This paper presents a fully customised integrated gate commutated thyristor(IGCT)gate driver monolithic integrated circuit(GDMIC),aiming to address the many shortcomings of traditional IGCT gate driver units composed of discrete components,such as the excessive number of components,low reliability,and complex development processes.The current-source driving characteristics of IGCTs pose significant technical challenges for developing fully customised integrated circuits(IC).The customised requirements of IGCT gate driver chips under various operating conditions are explored regarding functional module division,power sequencing,and chip parameter specifications.However,existing high-side(HS)driver methods exhibit limitations in functional monolithic integration and bipolar complementary metal-oxide-semiconductor compat-ibility.To address these challenges,a novel HS driving topology based on floating linear regulators is proposed.It can achieve synchronised control of multi-channel floating power transistors while supporting 100%duty cycle continuous conduction.The pro-posed GDMIC reduces the three independent HS power supplies to a single multiplexed topology,significantly decreasing circuit complexity.Experimental results validate the feasibility and performance of a 4-inch gate driver prototype based on IGCT current-source management IC,demonstrating significant advantages in reducing the number of components,enhancing device reliability,and simplifying development.The proposed GDMIC offers an innovative development path for future high-power IGCT drivers. 展开更多
关键词 high voltage integrated gate commutated thyristor gate driver fully customised integrated gate commutated thyristor gate driver monolithic integrated circuit power sequencing discrete componentssuch novel current source management integrated circuit integrated circuits ic integrated gate commutated thyristor igct gate functional module division
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