Nipah virus(NiV)is a zoonotic pathogen that causes severe neurological and respiratory diseases characterized by high mortality rates[1].The emergence of sporadic cases in Bangladesh in 2025 and subsequent infections ...Nipah virus(NiV)is a zoonotic pathogen that causes severe neurological and respiratory diseases characterized by high mortality rates[1].The emergence of sporadic cases in Bangladesh in 2025 and subsequent infections among healthcare workers in West Bengal in early 2026 highlight a significant epidemic potential[2].This risk is further exacerbated by the absence of licensed vaccines or targeted antiviral therapies[1,3,4].Consequently,there is an urgent need for strengthened surveillance and operational preparedness in low-and middle-income countries(LMICs),which often face resource-limited healthcare systems and overcrowded settings with inadequate infection prevention and control(IPC)measures[1,5].展开更多
To the Editor:Coronary artery disease(CAD)is the leading cause of mortality worldwide.Effective treatments,such as percutaneous coronary intervention(PCI),have reduced the mortality of patients with CAD and have trans...To the Editor:Coronary artery disease(CAD)is the leading cause of mortality worldwide.Effective treatments,such as percutaneous coronary intervention(PCI),have reduced the mortality of patients with CAD and have transitioned most of them to the chronic phase of cardiovascular disease(CVD).Consequently,there is a high demand for secondary prevention strategies to reduce adverse outcomes of CAD.Risk assessment can quantify the residual risk,identify patients at high secondary risk,and facilitate informed preventive treatment decisions.[1]However,the existing scoring systems for secondary risk,such as the Global Registry of Acute Coronary Events(GRACE)and Patterns of Non-Adherence to Anti-Platelet Regimen in Stented Patients(PARIS)scores,usually involve certain clinical indicators that are unfamiliar to the public and demonstrate poor performance when applied to Chinese patients;Thus,it limited their utility,especially as self-assessment tools.The Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)score is a guideline-recommended pragmatic tool for primary prevention using several conventional risk factors.[2]The risk factors related to primary CVD are likely implicated in the recurrent events because of the same underlying pathophysiology of atherosclerosis.展开更多
摘要Nipah virus(NiV)is a zoonotic pathogen that causes severe neurological and respiratory diseases characterized by high mortality rates[1].The emergence of sporadic cases in Bangladesh in 2025 and subsequent infections among healthcare workers in West Bengal in early 2026 highlight a significant epidemic potential[2].This risk is further exacerbated by the absence of licensed vaccines or targeted antiviral therapies[1,3,4].Consequently,there is an urgent need for strengthened surveillance and operational preparedness in low-and middle-income countries(LMICs),which often face resource-limited healthcare systems and overcrowded settings with inadequate infection prevention and control(IPC)measures[1,5].
基金supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project(Nos.2023ZD0504000 and 2023ZD0503500)the National Key Research and Development Program of China(Nos.2016YFC1301300,2016YFC1301301,2017YFC0211706,2018YFE0115300,and 2023YFC2506703)+2 种基金the National Natural Science Foundation of China(Nos.82473720 and 81770365)Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(No.2021-I2M-1-010)the National High Level Hospital Clinical Research Funding(No.2022-GSP-GG-2).
摘要To the Editor:Coronary artery disease(CAD)is the leading cause of mortality worldwide.Effective treatments,such as percutaneous coronary intervention(PCI),have reduced the mortality of patients with CAD and have transitioned most of them to the chronic phase of cardiovascular disease(CVD).Consequently,there is a high demand for secondary prevention strategies to reduce adverse outcomes of CAD.Risk assessment can quantify the residual risk,identify patients at high secondary risk,and facilitate informed preventive treatment decisions.[1]However,the existing scoring systems for secondary risk,such as the Global Registry of Acute Coronary Events(GRACE)and Patterns of Non-Adherence to Anti-Platelet Regimen in Stented Patients(PARIS)scores,usually involve certain clinical indicators that are unfamiliar to the public and demonstrate poor performance when applied to Chinese patients;Thus,it limited their utility,especially as self-assessment tools.The Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)score is a guideline-recommended pragmatic tool for primary prevention using several conventional risk factors.[2]The risk factors related to primary CVD are likely implicated in the recurrent events because of the same underlying pathophysiology of atherosclerosis.