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Rotarod training reverses corticosterone-induced motor deficits via oligodendrocyte lineage cell modulation 认领 引用
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作者 Jada Chia-Di Lee Benson Wui-Man Lau +6 位作者 Suk-Yu Yau Joseph Wai-Hin Leung Harmony Kai-Hei Wong Dalinda Isabel Sanchez Vidana Tatia M.C.Lee Wu-Tian Wu Kwok-Fai So 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2440-2447,共8页
Adult-born oligodendrocytes are continuously produced in the brains of rodents.The functional role of these cells has been linked to the motor-related activities of healthy animals and is vital for acquiring new motor... Adult-born oligodendrocytes are continuously produced in the brains of rodents.The functional role of these cells has been linked to the motor-related activities of healthy animals and is vital for acquiring new motor skills.However,the relationship between these cells and the control of motor-related activities has not been investigated in pathological conditions.Therefore,the aim of this study is to investigate the role of oligodendrocytes in depression-related motor deficits and the effects of training.Psychomotor retardation is a key symptom of depression.Consistent with the impairments observed in rodent motor performance,the proliferation and activation of adult-born oligodendrocytes are altered in a corticosterone-induced stress paradigm.Therapeutic rotarod training can alleviate these symptoms by reversing the aforementioned changes.Notably,these alterations are particularly pronounced in layer I of the motor cortex.Thus,this study provides evidence of the potential functional involvement of adult-born oligodendrocytes in the motor impairments observed in the depressed animals.Additionally,it offers preliminary results for further investigation into layer I of the motor cortex in relation to these pathological conditions. 展开更多
关键词 corticosterone-induced stress exercise major depressive disorder motor cortex motor deficits motor training myelination oligodendrocyte lineage cells oligodendrocyte precursor cells psychomotor retardation
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