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Causal relationships of inflammatory cytokines and serum metabolites with colorectal carcinoma: A Mendelian randomization study 认领 引用 被引量：1
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作者 FENG Sisi XIAO Xiaomin +2 位作者 ZHOU Manli HUANG Zixin ZHONG Baiyun 《中南大学学报（医学版）》 CAS CSCD 北大核心 2026年第1期118-128,共11页
Objective:The incidence and mortality of colorectal carcinoma(CRC)continue to rise globally,highlighting the need to identify modifiable risk factors for early detection and prevention.Previous studies have demonstrat... Objective:The incidence and mortality of colorectal carcinoma(CRC)continue to rise globally,highlighting the need to identify modifiable risk factors for early detection and prevention.Previous studies have demonstrated significant associations between CRC risk and various serum metabolites as well as inflammatory cytokines;however,due to limitations in study design and potential confounding factors,the causal relationships remain unclear.This study aims to investigate the causal relationships between inflammatory cytokines,serum metabolites,and CRC risk,providing a theoretical basis for the development of novel early diagnostic biomarkers and therapeutic targets.Methods:A two-sample Mendelian randomization(MR)design was applied using summary statistics from genome-wide association studies(GWAS).Instrumental variables(IVs)were derived from:1)metabolomics GWAS data of 1400 serum metabolites(n=8299);2)cytokine GWAS data of 91 inflammatory factors(n=14824);and 3)CRC risk data from the FinnGen consortium(6847 cases and 314193 controls).The primary analysis was conducted using the inverse-variance weighted(IVW)method,with sensitivity analyses performed using MR Egger regression and the weighted median method.Effect estimates including odds ratios(OR),95%confidence intervals(CI),and false discovery rates(FDR)were calculated.Results:MR analysis indicated that higher levels of axin-1(AXIN1)(OR=0.84195%CI 0.714 to 0.991)and Fms-related tyrosine kinase 3 ligand(Flt3L)(OR=0.916,95%CI 0.844 to 0.994)were associated with a reduced risk of CRC.In contrast,higher levels of Delta/Notchlike epidermal growth factor-related receptor(DNER)(OR=1.119,95%CI 1.009 to 1.241)and vascular endothelial growth factor A(VEGF-A)(OR=1.078,95%CI 1.011 to 1.150)were associated with an increased risk of CRC(all P<0.05).Metabolomics association analysis further identified 144 serum metabolites significantly correlated with these four key inflammatory cytokines(FDR<0.05),suggesting that they may regulate CRC risk through inflammatory pathways.Conclusion:Specific inflammatory cytokines and serum metabolites have causal relationships with the risk of CRC.These findings provide insights for further exploration of potential risk factors and the development of effective prevention strategies for CRC. 展开更多
关键词 inflammatory cytokines serum metabolites colorectal carcinoma Mendelian randomization genome-wide association study metabolomics analysis
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Application of Cytokines in Cervical Secretion for High-grade Squamous Intraepithelial Lesion Caused by High-risk Human Papillomavirus Infection 认领 引用
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作者 Lingyun Ji Xiao Wang +7 位作者 Ruixian Jiao Ji Yang Jiaqi Han Bowen Xu Yang Zhou Jing Wu Xiaowen Pu Wenhong Zhang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第2期215-222,共8页
Objective The aim of this study was to analyze the correlation between the levels of 12 cytokines in the cervical microenvironment and cervical intraepithelial neoplasia in patients with high-risk human papillomavirus... Objective The aim of this study was to analyze the correlation between the levels of 12 cytokines in the cervical microenvironment and cervical intraepithelial neoplasia in patients with high-risk human papillomavirus(HR-HPV)infection.Methods Female patients(n=73)with HR-HPV infection were enrolled and divided into a high-grade squamous intraepithelial lesion(HSIL)group(n=33)and a non-HSIL(N-HSIL)group(n=40),which include low-grade squamous intraepithelial lesions and inflammation.Healthy screening subjects(n=31)with negative HR-HPV results were enrolled as a control group.We examined contemporaneous plasma and secretory cytokines from 25 study subjects to investigate the difference between systemic cytokine profiles and the local microenvironment immunity using the Wilcoxon matched-pairs signed rank test.The 12 cytokines from cervical secretions were compared between the three groups using the Mann-Whitney test,and logistic regression was used to analyze HSIL and N-HSIL.Results There were statistical differences in eight cytokines(IL-2,IL-6,TNF-α,IFN-γ,IL-1β,IL-12p70,IFN-α,and IL-8)between cervical secretion and plasma of the same patient,and seven cytokines were statistically different between the control and other two groups.We selected four independent variables(TNF-α,IFN-γ,IL-12p70,and IFN-α)commonly identified by univariate regression analysis and non-parametric tests for multivariate logistic regression analysis.Based on this model,HSIL could be predicted in patients with HR-HPV infection,with the area under the curve being 0.76.Conclusion The systemic cytokine profile cannot reflect the local microenvironment immunity,and the occurrence of HSIL is related to the cytokine levels in the cervical microenvironment. 展开更多
关键词 High-risk human papillomavirus Cytokines High-grade squamous intraepithelial lesion
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Construction and validation of a multiparameter diagnostic model based on conventional tumor markers and cytokines for lung cancer 认领 引用 被引量：1
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作者 Yi-Ning Zhang Tao Jiang +1 位作者 Peng-Jun Zhang Hui-Juan Wang 《World Journal of Clinical Oncology》 2026年第4期140-148,共9页
BACKGROUND Early detection of lung cancer is urgently needed in clinical practice.AIM To evaluate the diagnostic value of conventional tumor markers and cytokines for lung cancer and construct a multiparameter diagnos... BACKGROUND Early detection of lung cancer is urgently needed in clinical practice.AIM To evaluate the diagnostic value of conventional tumor markers and cytokines for lung cancer and construct a multiparameter diagnostic model lung cancer detection.METHODS A total of 152 healthy controls and 113 lung cancer patients were included in the model.In addition,21 healthy controls and 36 lung cancer patients were separately included to validate the model.Three conventional tumor markers and 10 cytokines were detected.Four multiparameter joint analysis methods,binary logistic regression analysis,discriminant analysis,a classification tree and a neural network,were used to establish and compare multiparameter joint diagnosis models.RESULTS Six differentially expressed indicators[carcinoembryonic antigen(CEA),cytokeratin 19 fragment(CY211),neuronspecific enolase,interleukin(IL)-8,monocyte chemoattractant protein-1,and tumor necrosis factor-alpha(TNF-α)]were screened out,among which IL-8[area under the curve(AUC)=0.957]and TNF-α(AUC=0.936)had the optimal diagnostic efficacy.The binary logistic regression model was chosen as the optimal multiparameter combined auxiliary diagnostic model.When 152 healthy controls and 113 lung cancer s were differentiated via the model,the AUC was 0.980.After validation,when 21 healthy controls and 36 lung cancer patients were distinguished,the AUC was 0.922,indicating good stability and superior performance to that of CEA alone.CONCLUSION We constructed a multiparameter binary logistic regression diagnostic model that included CEA,CY211,IL-8 and TNF-αfor the auxiliary detection of lung cancer.Compared with conventional CEA,it significantly improved diagnostic accuracy. 展开更多
关键词 Lung cancer Tumor markers Cytokines Binary logistic regression Detection Carcinoembryonic antigen
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Causal relationships between 41 inflammatory cytokines and myopia:a Mendelian randomization study 认领 引用
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作者 Xiao-Fei Wu Lei Yu +3 位作者 Ying Zhang Shuang Li Rui Li Lian-Yi Sun 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第3期575-581,共7页
AIM:To investigate the potential causal associations between 41 inflammatory cytokines and myopia using a two-sample Mendelian randomization(MR)approach.METHODS:Publicly available genome-wide association study(GWAS)da... AIM:To investigate the potential causal associations between 41 inflammatory cytokines and myopia using a two-sample Mendelian randomization(MR)approach.METHODS:Publicly available genome-wide association study(GWAS)datasets were utilized for this two-sample MR analysis.Inflammatory cytokine-related GWAS data were extracted from The University of Bristol’s Research Data Repository,and myopia-related GWAS data were obtained from the FinnGen project.Single nucleotide polymorphisms(SNPs)associated with inflammatory cytokines were systematically selected as instrumental variables(IVs)based on three rigorous criteria:relevance,independence,and exclusion of pleiotropy.Five MR methods were employed for causal inference:the inverse-variance weighted(IVW)method as the primary analysis,supplemented by MREgger regression,weighted median estimator,simple mode,and weighted mode approaches.Sensitivity analyses were performed to evaluate the robustness of the causal estimates.RESULTS:A total of 773 myopia-associated SNPs were identified.MR analysis revealed that higher levels of macrophage inflammatory protein 1-α(MIP-1α)were associated with a 17%reduced risk of myopia[odds ratio(OR)=0.83;95%confidence interval(CI):0.69-0.99;P<0.05].In contrast,elevated levels of eotaxin(OR=1.26;95%CI:1.07-1.47;P<0.01),stromal cell-derived factor-1α(SDF-1α;OR=1.68;95%CI:1.08-2.62;P<0.05),and interleukin-2 receptor subunit alpha(IL-2Rα;OR=1.25;95%CI:1.01-1.53;P<0.05)were significantly associated with an increased risk of myopia.Sensitivity analyses confirmed the reliability of these results.CONCLUSION:This study provides evidence supporting a causal relationship between specific inflammatory cytokines and myopia.MIP-1αmay act as a protective factor against myopia,while eotaxin,SDF-1α,and IL-2Rαare potential risk factors for myopia.These findings emphasize the critical role of inflammatory pathways in the pathogenesis of myopia,offering novel insights for the development of preventive and therapeutic strategies for myopia. 展开更多
关键词 myopia inflammatory cytokines Mendelian randomization causal association single nucleotide polymorphism genome-wide association study
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Cytokines IL-6,IL-10,and CCL5 Secreted by Infiltrating B Cells Promote Cell Migration of Human Prostate Cancer Cell Lines 认领 引用
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作者 Crystal J.Byrd Monasia Evans +2 位作者 Woojung Kim Quintera Knight Geou-Yarh Liou 《Oncology Research》 SCIE 2026年第4期413-425,共13页
Objective:The progression of prostate cancer cells to metastasis is supported by their tumor microenvironment.Within this microenvironment,infiltrating immune cells,such as B cells,can be either anti-tumorigenic or pr... Objective:The progression of prostate cancer cells to metastasis is supported by their tumor microenvironment.Within this microenvironment,infiltrating immune cells,such as B cells,can be either anti-tumorigenic or pro-tumorigenic.Our preliminary data showed that a higher density of the infiltrating B cells was found near prostate cancer cells in human cancer tissues,as compared to the benign prostate tissue regions,thus suggesting that infiltrating B cells would promote the progression of prostate cancer cells.In this study,we aim to investigate the role of infiltrating B cells in enhancing the migratory ability of human prostate cancer cells.Methods:We utilized Transwell©R assays to evaluate the migratory ability of human prostate cancer cells in the presence or absence of B cells,B cell-secreted cytokines,and neutralizing antibodies of B cell-secreted cytokines.We also used Western blot and immunofluorescence staining to evaluate the effects of epithelial-mesenchymal transition on the human prostate cancer cells in response to the B cell cytokines.Results:Our findings showed an increase in migration of human prostate cancer cells in response to co-cultured B cells as well as the identified B cell cytokines:IL-6,IL-10,and CCL5.Neutralization of these cytokines through their specific neutralizing antibodies decreased B cell-induced prostate cancer cell migration.Results from Western blot and immunocytochemistry showed an increase in expression of N-cadherin and Slug,as well as disorganization of ZO-1,amongst the LNCaP cells treated with B cell cytokines.Conclusion:These results revealed that infiltrating B cells through their secretion factors enhanced prostate cancer cell migratory ability,which may lead to metastasis. 展开更多
关键词 Cytokines B cells human prostate cancer cells cell migration tumor microenvironment(TME)
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Role of tumor markers and cytokines in the pathogenesis of lung cancer 认领 引用
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作者 Maria Tariq Aqsa Sattar +4 位作者 Amber Khalid Minahil Azam Mehak Mehmood Ramsha Hafeez Saira Rafaqat 《World Journal of Clinical Oncology》 2026年第6期7-28,共22页
Lung cancer is characterized by the uncontrolled proliferation of abnormal cells in one or both lungs,typically originating from the epithelial lining of the airways.Cytokines are small,biologically active proteins th... Lung cancer is characterized by the uncontrolled proliferation of abnormal cells in one or both lungs,typically originating from the epithelial lining of the airways.Cytokines are small,biologically active proteins that function as signaling molecules,mediating communication between cells and regulating immune and inflammatory responses.In the context of lung cancer,cytokines play a crucial role in modulating the tumor microenvironment and influencing immune responses against malignant cells.Tumor markers and inflammatory cytokines are key contributors to the pathogenesis of lung cancer,facilitating tumor initiation,angiogenesis,and disease progression within an inflammatory microenvironment.Numerous tumor markers and cytokines have been identified and investigated in relation to lung cancer development and progression.However,we focused on carcinoembryonic antigen,squamous cell carcinoma,cytokeratin 19 fragment,tumor necrosis factor-alpha,granulocyte-macrophage colony-stimulating factor,interferon-γ,interleukin(IL)-1,IL-2,IL-4,IL-6,IL-8,IL-10,monocyte chemoattractant protein-1 and neuron-specific enolase in the pathogenesis of lung cancer.Furthermore,they promote immune evasion,epithelial-mesenchymal transition,and metastatic dissemination,thereby serving as important diagnostic,prognostic,and therapeutic targets.These biologically active molecules can modulate the immune response,enhancing the body’s ability to inhibit tumor growth and promote the destruction of lung cancer cells.By stimulating immune effector mechanisms and regulating signaling pathways involved in tumor progression,cytokine-based therapies contribute to improved anti-tumor immunity and represent promising strategies in the management of lung cancer. 展开更多
关键词 Lung cancer Tumor markers Cytokines Pathogenesis Clinical implications
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Targeted analysis of sphingolipids and cytokines in plasma of dairy cows after calving reveals distinct impacts of systemic inflammation,ketosis,and mastitis 认领 引用
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作者 Elodie Lassallette Alix Pierron Baysse +2 位作者 Blandine Gausseres Gilles Foucras Philippe Guerre 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第2期842-866,共25页
Background Sphingolipids(SL)are key regulators of inflammatory processes,yet their roles in dairy cows remain poorly understood.This study investigated the effects of inflammation(plasma haptoglobin concentration),ket... Background Sphingolipids(SL)are key regulators of inflammatory processes,yet their roles in dairy cows remain poorly understood.This study investigated the effects of inflammation(plasma haptoglobin concentration),ketosis,and mastitis on plasma SL profiles in Holstein cows sampled seven days postpartum.From a cohort of 427 cows across 25 farms,80 animals were classified into four groups:inflammation(n=20),ketosis(n=19),mastitis(n=21),and healthy controls(n=20).Plasma SL were quantified by targeted HPLC-MS/MS,while cytokines were quantified with a 15-plex bead-based assay.Both univariate and multivariate analyses were applied to assess pathological effects,along with SL ratios and correlations between SL and cytokines.Results Systemic inflammation detected through the haptoglobin measure induced the most pronounced alterations in SL metabolism,characterized by elevated dihydrosphingomyelins(DHSM)and lactosylceramides(Lac Cer),higher C22-24:C16 ratios,and lower unsaturated:saturated ratios in ceramides(Cer)and sphingomyelins(SM).Although total Cer,SM,and the Cer:SM ratio remained unchanged,specific reductions were observed in both Cer and SM in C14,Cer C18:1,SM C16:1,and SM C23:1,whereas SM C25:0 and C26:0 increased.Sphingosine-1-phosphate(So1P)was positively correlated with IL-10 as well as IL-1α and TNFα,while C18-20 Cer correlated positively with multiple pro-inflammatory cytokines and chemokines such as CXCL8 and CCL2.Ketosis induced subtler changes,primarily an increase in plasma DHSM and DHSM:SM ratio(driven by C16:0),an increase in C22-24:C16 DHCer ratio,and a decrease in both Lac So:Lac Cer and unsaturated:saturated ratios in C23-SM.In this group,So1P correlated positively with CXCL8 and CCL2.Moreover C18-20 Cer and DHCer were positively associated with CXCL8,CCL2,CCL3,and CCL4,which also showed correlations with most Lac Cer species.Analysis of chronic mastitis cases yielded a clear separation from controls in multivariate analysis but only minimal changes in SL concentrations and ratios,maybe due to the localized nature of the inflammatory response.Conclusions In summary,heightened inflammatory response in early post-partum is associated with the strongest systemic effects on SL metabolism,followed by ketosis,while mastitis induced only modest alterations.These findings highlight condition-specific patterns of SL regulation postpartum and suggest potential immunometabolic biomarkers of disease. 展开更多
关键词 Cytokines Dairy cow Disease Postpartum Sphingolipids
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Common gamma chain cytokines-driven optimization of chimeric antigen receptor T cells: Mechanistic insights and future directions 认领 引用
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作者 Dian-Bao Zuo Zi-Hao Chen +7 位作者 Yu-Meng Jin Ming Sang Xiao-Dong Sun Ai Guo Xiao-Yang Li Jin-Xiang Wu Kang-Kang Ji Hai Zhou 《World Journal of Clinical Oncology》 2026年第2期6-22,共17页
Malignant tumors represent a major threat to human life and health,posing persistent challenges in medical research.While chimeric antigen receptor T(CAR-T)cell therapy has demonstrated breakthrough efficacy in hemato... Malignant tumors represent a major threat to human life and health,posing persistent challenges in medical research.While chimeric antigen receptor T(CAR-T)cell therapy has demonstrated breakthrough efficacy in hematological malignancies such as leukemia and lymphoma,its application in solid tumors,including hepatocellular carcinoma,lung cancer,and pancreatic cancer,remains constrained by multiple bottlenecks.These limitations encompass the immunosuppressive tumor microenvironment,insufficient in vivo persistence of CAR-T cells,long-term treatmentinduced exhaustion,and off-target toxicity.The interleukin(IL)-2 family cytokines,IL-2,IL-4,IL-7,IL-9,IL-15,and IL-21,also known as gamma chain(γc)cytokines,share theγc(CD132)-Janus kinase 1/3-signal transducer and activator of transcription signaling axis.These cytokines precisely regulate the survival,proliferation,and functional differentiation of immune cells,including T cells and natural killer cells.In CAR-T immunotherapy,γc cytokines are applied in four core scenarios:Facilitating efficient in vitro CAR-T cell expansion to meet therapeutic dosing requirements;enhancing in vivo persistence to extend the therapeutic window;reinforcing effector functions to counteract tumor microenvironment-mediated suppression;and enabling precise cytokine release to mitigate toxicity risks.Technological strategies have evolved from early recombinant protein administration(in vitro and in vivo)to second-generation“armored”CAR-T cells engineered for autocrine cytokine secretion and further to thirdgeneration programmable cytokine circuits using synthetic biology for spatiotemporal control.This review systematically summarizes the mechanistic roles,research progress,and technological evolution ofγc cytokines in optimizing CAR-T cell function.It critically analyzes the advantages and limitations of different application strategies and explores their potential to overcome solid tumor treatment bottlenecks while improving CAR-T therapy safety and efficacy.These insights aim to inform basic research and clinical translation in this field. 展开更多
关键词 Chimeric antigen receptor T therapy Gamma chain cytokines Solid tumors Tumor microenvironment Clinical translation
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Understanding the mechanistic and therapeutic perspectives on cytokines and chemokines in acute high-altitude illness syndromes 认领 引用
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作者 Amin Ullah Rajeev K.Singla +2 位作者 Yingbo Zhang ShanShan Hu Bairong Shen 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2025年第9期2004-2021,共18页
Acute high-altitude(HA)illnesses(AHAIs),including acute mountain sickness(AMS),HA cerebral edema(HACE),and HA pulmonary edema(HAPE),represent significant health challenges for individuals rapidly ascending to high alt... Acute high-altitude(HA)illnesses(AHAIs),including acute mountain sickness(AMS),HA cerebral edema(HACE),and HA pulmonary edema(HAPE),represent significant health challenges for individuals rapidly ascending to high altitudes.Cytokines(interleukins(ILs))and chemokines,which are involved in inflammatory and immunological responses,regulate the response of the body to hypoxic stress.Their dysregulation can contribute to the clinical symptoms of AMS,HACE,and HAPE by increasing vascular permeability,causing edema and damaging tissue.AHAIs elevate the levels of pro-inflammatory cytokines and chemokines,such as IL-17,tumor necrosis factorα(TNF-α),IL-1,IL-6,C−X−C motif chemokine ligand(CXCL)10,CXCL8,C−C motif ligand 2(CCL2),and CCL3,exacerbating symptoms.Thus,this review focuses on the cytokines and chemokines involved in AHAIs and the molecular mechanisms that extend beyond these cytokines and chemokines in clinical and preclinical contexts.Identifying these mediators and pathways helps researchers design drugs that reduce symptoms,slow disease progression,and enhance outcomes.Cytokines and chemokines have complex functions in these disorders and may serve as prospective therapeutic targets.Finally,we discuss treatment possibilities for AHAIs(drugs,exercise,and other inhibitors).This knowledge will help us to protect and improve the health of individuals at high altitudes. 展开更多
关键词 Acute high-altitude illness Acute mountain sickness High-altitude cerebral edema High-altitude pulmonary edema Cytokines Chemokines Therapeutic targets
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Dynamic alterations in bacterial and fungal microbiome and inflammatory cytokines following SRV-8 infection in cynomolgus monkeys 认领 引用 被引量：1
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作者 Yun-Peng Yang Li-Bing Xu +3 位作者 Yong Lu Jing Wang Yan-Hong Nie Qiang Sun 《Zoological Research》 SCIE CAS CSCD 2025年第2期325-338,共14页
While viral infections can disturb the host gut microbiome,the dynamic alterations in microbial composition following infection remain poorly characterized.This study identified SRV-8-infected monkeys and classified t... While viral infections can disturb the host gut microbiome,the dynamic alterations in microbial composition following infection remain poorly characterized.This study identified SRV-8-infected monkeys and classified them into five groups based on infection progression.16S rRNA amplicon sequencing revealed significant alterations in the relative and inferred absolute abundance of bacterial genera UCG-002,Agathobacter,Coprococcus,and Holdemanella during the early stage of SRV-8 infection,coinciding with provirus formation.These microbial shifts were accompanied by functional modifications in bacterial communities at the same stage.In contrast,ITS amplicon sequencing indicated no significant differences in fungal composition between healthy wild-type and SRV-8-infected monkeys.Spearman correlation analyses demonstrated close interactions between intestinal bacteria and fungi following SRV-8 infection.Additionally,SRV-8 seropositive groups exhibited significantly elevated mRNA expression levels of pro-inflammatory(TNF-α,IFN-γ,IL-1β,and IL-6)and anti-inflammatory(IL-10)cytokine genes,highlighting close associations between inflammatory cytokines and immune responses.Overall,these findings provide a comprehensive characterization of bacterial and fungal microbiota dynamics and inflammatory cytokine responses associated with SRV-8 infection,clarifying the pathobiological mechanisms underlying SRV-8 infection from the perspective of the gut microbiome. 展开更多
关键词 Cynomolgus monkeys SRV-8 infection Dynamic alterations Bacterial and fungal microbes Inflammatory cytokines
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Serum pro-inflammatory cytokines as potential biomarkers for the diagnosis of gastric carcinoma 认领 引用 被引量：1
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作者 Le Ren Jun Liu +1 位作者 Ya-Yun Xu Zhen-Wang Shi 《World Journal of Clinical Oncology》 2025年第5期90-98,共9页
BACKGROUND Multiple lines of evidence have indicated that pro-inflammatory cytokines play a role in the pathophysiology of gastric carcinoma(GC).AIM To identify potential serum cytokine-based biomarkers for GC diagnos... BACKGROUND Multiple lines of evidence have indicated that pro-inflammatory cytokines play a role in the pathophysiology of gastric carcinoma(GC).AIM To identify potential serum cytokine-based biomarkers for GC diagnosis.METHODS The study cohort comprised 50 patients diagnosed with GC and 50 healthy control subjects.A panel of 7 pro-inflammatory cytokines,including interleukin(IL)-1β,IL-2,IL-6,IL-8,IL-12,tumor necrosis factor-α,and interferon-γ(IFN-γ)were quantified using multiplex Luminex assays.Comparative analyses were conducted to evaluate cytokine levels between the GC patients and healthy controls.The diagnostic potential of serum pro-inflammatory cytokines in differentiating GC patients from healthy individuals was assessed through receiver operating characteristic(ROC)curve analysis.The correlation between serum cytokine levels and disease severity,as classified by the tumor-node-metastasis staging system,was analyzed using Spearman's rank correlation coefficient.RESULTS In comparison to the control group,patients with GC demonstrated significantly elevated serum levels of IL-1β(t=-4.089,P<0.001),IL-6(t=-3.983,P<0.001),IL8(t=-5.460,P<0.001),and IFN-γ(t=-2.856,P=0.005).ROC curve analysis indicated that the area under the curve values for IL-1β,IL-6,and IL-8 exceeded 0.7,effectively distinguishing GC patients from healthy controls.Additionally,serum levels of IL-1β(r=0.424,P=0.012)and IL-6(r=0.742,P<0.001)were positively correlated with the T stage in GC patients.Similarly,serum concentrations of IL-1β(r=0.356,P=0.039)and IL-6(r=0.441,P=0.008)exhibited a positive association with the N stage in these patients.CONCLUSION These findings suggest that circulating pro-inflammatory cytokines,such as IL-1β,IL-6,and IL-8,may serve as potential biomarkers for the diagnosis of GC. 展开更多
关键词 Gastric carcinoma Pro-inflammatory cytokines Serum Biomarker Diagnosis
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Harnessing early enzymatic biomarkers and cytokines for risk prediction in post-endoscopic retrograde cholangiopancreatography pancreatitis 认领 引用
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作者 Abdellatif Bouayad 《World Journal of Gastroenterology》 SCIE CAS 2025年第48期1-6,共6页
This editorial critically analyses the recent article by Jung et al,which investigates the utility of 4-hour serum amylase and lipase as early blood markers for postendoscopic retrograde cholangiopancreatography(ERCP)... This editorial critically analyses the recent article by Jung et al,which investigates the utility of 4-hour serum amylase and lipase as early blood markers for postendoscopic retrograde cholangiopancreatography(ERCP)acute pancreatitis prediction.Although these enzymes are valuable for the early diagnosis of post-ERCP pancreatitis,they lack specificity for disease etiology and provide limited insight into the molecular mechanisms underlying disease progression.Several cytokines,notably interleukin(IL)-6,tumor necrosis factor-alpha,and IL-8,are increased in post-ERCP pancreatitis and may serve as potential predictors for disease severity.The incorporation of these biomarkers in early enzymatic biomarkers and established prognostic scoring systems could further enhance their accuracy and allow for earlier,more effective management of patients with post-ERCP pancreatitis. 展开更多
关键词 Cytokines Enzymatic biomarkers Post-endoscopic retrograde cholangiopancreatography pancreatitis Early diagnosis Prognosis
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Role of inflammatory cytokines in peripheral nerve injury 认领 引用 被引量：7
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作者 Federica Fregnan Luisa Muratori +2 位作者 Anabel Rodriguez Simǒes Maria Giuseppina Giacobini-Robecchi Stefania Raimondo 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第29期2259-2266,共8页
Inflammatory events occurring in the distal part of an injured peripheral nerve have, nowadays, a great resonance. Investigating the timing of action of the several cytokines in the important stages of Wallerian degen... Inflammatory events occurring in the distal part of an injured peripheral nerve have, nowadays, a great resonance. Investigating the timing of action of the several cytokines in the important stages of Wallerian degeneration helps to understand the regenerative process and design pharmacologic intervention that promotes and expedites recovery. The complex and synergistic action of inflammatory cytokines finally promotes axonal regeneration. Cytokines can be divided into pro- and anti-inflammatory cytokines that upregulate and downregulate, respectively, the production of inflammatory mediators. While pro-inflammatory cytokines are expressed in the first phase of Wallerian degeneration and promote the recruitment of macrophages, anti-inflammatory cytokines are expressed after this recruitment and downregulate the production of all cytokines, thus determining the end of the process. In this review, we describe the major inflammatory cytokines involved in Wallerian degeneration and the early phases of nerve regeneration. In particular, we focus on interleukin-1, interleukin-2, interleukin-6, tumor necrosis factor-β, interleukin-10 and transforming growth factor-β. 展开更多
关键词 pro-inflammatory cytokines anti-inflammatory cytokines inflammatory reaction peripheral nervoussystem nerve injury wallerian degeneration Schwann cells macrophage axonal regeneration myelin neural regeneration
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Involvement of pro-inflammatory and anti-inflammatory cytokines in the anti-inflammatory activity of Rubus idaeus L.on LPS-treated RAW 264.7 cells 认领 引用 被引量：16
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作者 肖飞 朱江 +6 位作者 赵雷 郑国华 杨安树 陶君彦 张宝徽 黄志军 熊富良 《Journal of Chinese Pharmaceutical Sciences》 CAS 2010年第3期201-208,共8页
Anti-inflammatory activity ofRubus idaeus L. and possible mechanisms involved were explored in lipopolysaccharide （LPS）-treated RAW 264.7 cells. The effects of ethanol extract of R. idaeus on the levels of pro-infla... Anti-inflammatory activity ofRubus idaeus L. and possible mechanisms involved were explored in lipopolysaccharide （LPS）-treated RAW 264.7 cells. The effects of ethanol extract of R. idaeus on the levels of pro-inflammatory cytokines, including tumor necrosis factor-alfa （TNF-α）, interleukin-6 （IL-6） and interleukin-1 beta （IL-1β）, as well as pro-inflammatory mediators, such as nitric oxide （NO）, inducible nitric oxide synthase （iNOS） and cyclooxygenase-2 （COX-2） were studied by Sandwich ELISA, real-time PCR, and Western blot analysis. Moreover, the effects of ethanol extract of R. idaeus on anti-inflammatory cytokine interleukin-10 （IL-10） and anti-inflammatory mediator heme oxygenase-1 （HO-1） were also investigated using the same methods. Furthermore, nuclear factor-gB （NF-κB） level was assayed by immunocytochemistry. The results showed that the production of IL-1β, IL-6, NO, TNF-α and COX-2 in LPS-treated cells could be significantly inhibited （P〈0.01 or P〈0.05） by ethanol extract ofR. idaeus compared with that in the cells treated with LPS only. Meanwhile, the production of NF-r,B was also inhibited by the extract. Based on these results, the anti-inflammatory activity ofR. idaeus was attributed to the down-regulation of IL-6, IL-1β and TNF-α levels as well as gene expression of iNOS and COX-2 through the suppression of NF-κB activation, and induction of anti-inflammatory cytokine IL- 10 and anti-inflammatory mediator HO- 1. 展开更多
关键词 Rubus idaeus L. RAW 204.7 cell NF-κB Pro-inflammatory cytokines Anti-inflammatory cytokines
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Study of the mechanisms of acupuncture and moxibustion treatmentfor ulcerative colitis ratsinview of the gene expression of cytokines 认领 引用 被引量：47
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作者 Wu HG Zhou LB +4 位作者 Pan YY Huang C Chen HP Shi Z Hua XG 《World Journal of Gastroenterology》 SCIE CAS 1999年第6期515-517,共3页
AIM:To observe the effect of acupuncture and moxibustion on the expression of IL-1beta and IL-6 mRNA in ulcerative colitis rats.METHODS:The SD rat ulcerative colitis model was created by immunological method associate... AIM:To observe the effect of acupuncture and moxibustion on the expression of IL-1beta and IL-6 mRNA in ulcerative colitis rats.METHODS:The SD rat ulcerative colitis model was created by immunological method associated with local stimulation. Colonic mucosa was prepared from human fresh surgical colonic specimens, homogenized by adding appropriate amount of normal saline and centrifuged at 3000r/min. The supernatant was collected for measurement of protein conentration and then mixed with Freund adjuvant. This antigen fluid was first injected into the plantae of the model group rats, and then into their plantae, dorsa, inguina and abdominal cavities (noFreund adjuvant for the last injection) again on the 10th, 17th, 24th and 31st day. When a certain titer of serum anti colonic antibody was reached, 2% formalin and antigen fluid (no Freund adjuvant) were administered separately by enema. The ulcerative colitis rat model was thus set up. The animals were randomly divided into four groups: model control group (MC, n = 8), electro acupuncture group (EA, n = 8), herbs partition moxibustion group (HPM 8), normal control group (NC,n = 8). HPM: Moxa cones made of refined mugwort floss were placed on the medicinal pad (medicinal pad dispensing: Radix Aconiti praeparata, cortex Cinnamomi, etc) for Qihai (RN 6) and Tianshu (ST 25, bilateral) and ignited. Two moxa cones were used for each acupoint once a day and 14 times in all. EA: Tianshu (bilateral) and Qihai were stimulated by the intermittent pulse with 2Hz frequency, 4mA intensity for 20 minutes once a day and 14 times in all. After treatment, rats of all four groups were killed simultaneously. The spleen was separated and the distal colon was dissected. Total tissue RNA was isolated by the guanidinium thiocyanate phenol chloroform extraction method. RT-PCR technique was used to study the expression of IL-1 beta and IL-6 mRNA.RESULTS:IL-1 beta and IL-6 mRNAs were not detected in the spleen and colonic mucosa of the NC rats, whereas they were significantly expressed in that of the MC rats.IL-1 beta and IL-6 mRNAs were markedly lower in the EA and HPM rats than that in MC rats. There was no significant difference between the levels of IL-1 beta and IL-6 mRNAs in the EA and HPM rats. The expressions of IL-1 beta and IL-6 mRNAs were nearly the same in the spleen and colon of all groups.CONCLUSION:Acupuncture and moxibustion greatly inhibited the expression of IL-1 beta and IL-6 mRNA in the experimental ulcerative colitis rats. 展开更多
关键词 colitis, ulcerativeherapy acupuncture and moxibustion therapy gene expression cytokines interleukin-1 beta interleukin-6
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Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines 认领 引用 被引量：24
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作者 Shan-Shan Rao Yin Hu +16 位作者 Ping-Li Xie Jia Cao Zhen-Xing Wang Jiang-Hua Liu Hao Yin Jie Huang Yi-Juan Tan Juan Luo Ming-Jie Luo Si-Yuan Tang Tuan-Hui Chen Ling-Qing Yuan Er-Yuan Liao Ran Xu Zheng-Zhao Liu Chun-Yuan Chen Hui Xie 《Bone Research》 SCIE CAS CSCD 2018年第2期177-188,共12页
Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing bone form... Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing bone formation. Omentin-1 is a newly identified adipocytokine that has anti-inflammatory effects, but little is known about the role of omentin-1 in inflammatory osteoporosis. Here we generated global omentin-1 knockout（omentin-1^-/-） mice and demonstrated that depletion of omentin-1 induces inflammatory bone loss-like phenotypes in mice, as defined by abnormally elevated pro-inflammatory cytokines, increased osteoclast formation and bone tissue destruction, as well as impaired osteogenic activities. Using an inflammatory cell model induced by tumor necrosis factor-α（TNF-α）, we determined that recombinant omentin-1 reduces the production of proinflammatory factors in the TNF-α-activated macrophages, and suppresses their anti-osteoblastic and pro-osteoclastic abilities. In the magnesium silicate-induced inflammatory osteoporosis mouse model, the systemic administration of adenoviral-delivered omentin-1 significantly protects from osteoporotic bone loss and inflammation. Our study suggests that omentin-1 can be used as a promising therapeutic agent for the prevention or treatment of inflammatory bone diseases by downregulating the proinflammatory cytokines. 展开更多
关键词 TNF Omentin-1 prevents inflammation-induced osteoporosis downregulating pro-inflammatory cytokines RANKL
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Triptolide Inhibits Expression of Inflammatory Cytokines and Proliferation of Fibroblast-like Synoviocytes Induced by IL-6/sIL-6R-Mediated JAK2/STAT3 Signaling Pathway 认领 引用 被引量：28
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作者 Jian-jing LIN Ke TAO +4 位作者 Nan GAO Hui ZENG De-li WANG Jun YANG Jian WENG 《Current Medical Science》 SCIE CAS 2021年第1期133-139,共7页
Triptolide,a component of the Chinese herb Tripterygium wilfordii Hook F,has been proved to be effective in the treatment of rheumatoid arthritis(RA).However,its underlying mechanisms on RA have not yet been well esta... Triptolide,a component of the Chinese herb Tripterygium wilfordii Hook F,has been proved to be effective in the treatment of rheumatoid arthritis(RA).However,its underlying mechanisms on RA have not yet been well established.We observed the inhibitory effect of triptolide on the expression of inflammatory cytokines and proliferation of fibroblast-like synoviocytes(FLS)induced by the complex of interleukin-6(IL-6)and the soluble form of the IL-6 receptor(sIL-6R).Furthermore,to clarify the underlying mechanisms,we treated FLS with the Janus-activated kinase 2(JAK2)inhibitor/signal transducer and activator of transcription 3(STAT3)activation blocker AZD1480.In this study,immunohistochemical staining was used to identify vimentin(+)and CD68(−)in FLS.The FLS proliferation was measured by cell proliferation assay,and the cell cycles were analyzed by flow cytometry.Furthermore,ELISA was used to detect the expression of the inflammatory factors in culture solution.The expression levels of p-JAK2,JAK2,p-STAT3 and STAT3 were investigated through Western blotting analysis.The results showed that IL-6/sIL-6R significantly increased the cell proliferation and expression of inflammatory cytokines,including IL-6,interleukin-1β(IL-1β)and vascular endothelial growth factor(VEGF).Triptolide or AZD1480 inhibited the cell proliferation and inflammatory cytokine expression in IL-6/sIL-6R-stimulated FLS by suppressing JAK2/STAT3.The study suggested that the physiological effects of triptolide on RA were due to its contribution to the inhibition of the inflammatory cytokine expression and FLS proliferation by suppressing the JAK2/STAT3 signaling pathway.It may provide an innovative insight into the effect of triptolide in preventing RA pathogenesis. 展开更多
关键词 triptolide inflammatory cytokines proliferation fibroblast-like synoviocytes JAK2/STAT3
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Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis 认领 引用 被引量：29
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作者 Xiao-Dong Peng Li-Li Dai +2 位作者 Chang-Quan Huang Chun-Mei He Li-Juan Chen 《World Journal of Gastroenterology》 SCIE CAS 2009年第37期4720-4725,共6页
AIM： To investigate the correlation between the antifibrotic effect of baicalin and serum cytokine production in rat hepatic fibrosis, METHODS： Forty male Sprague-Dawley rats were divided randomly into four groups：... AIM： To investigate the correlation between the antifibrotic effect of baicalin and serum cytokine production in rat hepatic fibrosis, METHODS： Forty male Sprague-Dawley rats were divided randomly into four groups： normal control group, model group, baicalin-treated group, and colchicine-treated group. Except for the normal control group, all rats in the other groups were administered with carbon tetrachloride to induce hepatic fibrosis. At the same time, the last two groups were also treated with baicalin or colchicine. At the end of the 8 wk, all animals were sacrificed. Serum alanine aminotransferase （ALl＇）, aspartate aminotransferase （AST）, transforming growth factor （TGF）-β1, tumor necrosis factor （TNF）-α, interleukin （IL）-6 and IL-10 were measured. Liver index, hepatic hydroxyproline content and the degree of liver fibrosis were also evaluated. RESULTS： The levels of ALT, AST and liver index in the baicalin-treated group were markedly lower than those in the model group （ALT： 143.88 ± 14.55 U/L vs 193.58± 24.35 U/L; AST： 263.66 ± 44.23 U/L vs 404.37± 68.29 U/L; liver index： 0.033 ± 0.005 vs 0.049± 0.009, P 〈 0.01）. Baicalin therapy also significantly attenuated the degree of hepatic fibrosis, collagen area and collagen area percentage in liver tissue （P 〈 0.01）. Furthermore, the levels of serum TGF-β1, TNF-α and IL-6 were strikingly reduced in the baicalin-treated group compared with the model group, while the production of IL-10 was up-regulated： （TGF-β1：260.21 ± 31.01 pg/mL vs 375.49 ± 57.47 pg/mL; TNF-α： 193.40±15.18 pg/mL vs 260.04 ± 37.70 pg/mL; IL-α：339.87 ± 72.95 pg/mL vs 606.47 ± 130.73 pg/mL; IL-10：506.22 ± 112.07 pg/mL vs 316.95 ± 62.74 pg/mL, P 〈 0.01）. CONCLUSION： Baicalin shows certain therapeutic effects on hepatic fibrosis, probably by immunoregulating the imbalance between profibrotic and antifibrotic cytokines. 展开更多
关键词 Baicalin Hepatic fibrosis Hepatic stellate cell Cytokines
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Polymorphisms of some cytokines and chronic hepatitis B and C virus infection 认领 引用 被引量：20
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作者 Qiu-Ju Gao Dian-Wu Liu +5 位作者 Shi-Yong Zhang Min Jia Li-Min Wang Li-Hong Wu Shu-Yun Wang Li-Xin Tong 《World Journal of Gastroenterology》 SCIE CAS 2009年第44期5610-5619,共10页
AIM： To study the relationship between the polymorphisms in some cytokines and the outcome of hepatitis B virus （HBV） and hepatitis C virus （HCV） infection. METHODS： Samples were obtained from 203 patients infec... AIM： To study the relationship between the polymorphisms in some cytokines and the outcome of hepatitis B virus （HBV） and hepatitis C virus （HCV） infection. METHODS： Samples were obtained from 203 patients infected with HBV and/or HCV while donating plasma in 1987, and 74 controls were obtained from a rural area of North China. Antibodies to HBV or HCV antigens were detected by enzyme-linked imrnunoassay. The presence of viral particles in the serum was determined by nested reverse-transcriptase polymerase chain reaction （PCR）. Hepatocellular injury, as revealed by alanine aminotransferase （ALT） and aspartate aminotransferase level, was detected by a Beckman LX-20 analyzer. DNA was extracted from blood cells. Then, the single nucleotide polymorphisms of IL-2-330, IFN-γ＋874, IL-10-1082/-592 and IL-4-589 were investigated by restriction fragment length polymorphism-PCR or sequence specific primer-PCR.RESULTS： Persistent infection with HBV, HCV, and HBV/HCV coinfection was associated with IL-2-330 TT genotype and T allele, IFN-γ＋874 AA genotype, and IL-10-1082 AA genotype. The clinical outcome of HBV and/or HCV infection was associated with IL-2-330 TT genotype and T allele, IFN-γ＋874 AA genotype, and IL-10-1082 AA genotype. IL-2-330 GG genotype frequency showed a negative correlation with clinical progression, IL-10-1082 AA genotype frequency showed a positive correlation and IL-10-1082 AG genotype frequency showed a negative correlation with clinical progression. HCV RNA positive expression was associated with IL-10-1082 AA genotype and the A allele frequency. Abnormal serum ALT level was associated with IL-10-592 AC genotype frequency and IL-4-589 CC genotype, CT genotype, and the C allele. CONCLUSION： These results suggest that polymorphisms in some cytokine genes influence persistent HBV and HCV infection, clinical outcome, HCV replication, and liver damage. 展开更多
关键词 Hepatitis B Hepatitis C Single nucleotide polymorphism Disease susceptibility Outcome studies Cytokines
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Alterations of biliary biochemical constituents and cytokines in infantile hepatitis syndrome 认领 引用 被引量：21
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作者 Yan Ding Lei Zhao +2 位作者 Hong Mei Zhi-Hua Huang Shu-Ling Zhang 《World Journal of Gastroenterology》 SCIE CAS 2006年第43期7038-7041,共4页
AIM: To investigate the biliary biochemical constituents and cytokines in infantile hepatitis syndrome (IHS). METHODS: From 42 IHS subjects and 21 controls, serum and biliary biochemical constituents, including total ... AIM: To investigate the biliary biochemical constituents and cytokines in infantile hepatitis syndrome (IHS). METHODS: From 42 IHS subjects and 21 controls, serum and biliary biochemical constituents, including total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (γ-GT), total bile acid (TBA), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) both in bile and serum, were assayed. The subjects with IHS were divided into a cholestasis group (n = 21) and a hepatitis group (n = 21). RESULTS: In the cholestasis group, serum TBIL, DBIL, ALT, γ-GT, TBA, IL-6 and TNF-α levels were higher than those in the control (P < 0.01); and also the biliary TBIL, DBIL, γ-GT and TBA levels were lower than those in the control, whereas biliary IL-6 and TNF-α levels were higher than those in the control (P < 0.01). In the cholestasis group, serum IL-6 and TNF-α levels were lower than those in bile (P < 0.01). In the hepatitis group, serum DBIL, ALT, γ-GT, TBA, IL-6 and TNF-α levels were higher than those in the control (P < 0.01 or 140.57 ± 70.32 vs 79.06 ± 35.25, P < 0.05), while biliary TBIL, DBIL, γ-GT and TBA levels were lower than those in the control (P < 0.01), and biliary IL-6 and TNF-α levels were higher than those in the control (P < 0.01). In the hepatitis group, serum IL-6 and TNF-α levels were also lower than those in bile (P < 0.01). Serum TBIL, DBIL, γ-GT, IL-6 and TNF-α levels in the cholestasis group were higher than those in the hepatitis group, while biliary IL-6 and TNF-α levels in the cholestasis group were higher than those in the hepatitisgroup. Biliary IL-6 and TNF-α were found to be more significantly increased than serum IL-6 and TNF-α in IHS (P < 0.01). The biliary IL-6 and TNF-α levels were positively correlated with serum DBIL, TBA and γ-GT levels in IHS subjects. CONCLUSION: Biliary biochemical constituents alter in coincidence with pathological changes in hepatocellular injury. Cholestasis is more serious in IHS patients of cholestasis subtype. Assay of biliary IL-6 and TNF-α levels can be specific and sensitive to determine the inflammatory status of impaired liver in IHS. 展开更多
关键词 Infantile hepatitis syndrome Biliarybiochemical constituents Biliary cytokines Interleukin-6 Tumor necrosis factor-α
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