A cluster-based organization with two phases to separate priority calculation and network activity operations is developed. In the election-state phase, clusters are organized by those nodes with sufficient residual e...A cluster-based organization with two phases to separate priority calculation and network activity operations is developed. In the election-state phase, clusters are organized by those nodes with sufficient residual energy level(REL) that are distributed as evenly as possible in the network. For each network round, each node decides its role(such as, cluster header(CH) or a normal node) and its priority level for activity operation. The priority level also affects the active/sleep scheduling in the node. In the steady-state phase, the positive priority levels of active nodes determine their activity order to avoid transmission collision, and to reduce redundant data transmission and sensing coverage. Since the data reporting to the sink is usually performed by a CH delivery chain, subsidiary CHs are selected to assist with data delivery and to share the loading of CHs. The formulae for computing priority levels are analyzed and verified by the examples with valid parameters. The experimental results show that the two phases efficiently consume node energy and achieve energy savings.展开更多
BACKGROUND The diagnosis of ovarian-adnexal lesions is challenging due to the variability in radiologist experience,which may lead to inconsistent diagnostic outcomes.The ovarian-adnexal reporting and data system(O-RA...BACKGROUND The diagnosis of ovarian-adnexal lesions is challenging due to the variability in radiologist experience,which may lead to inconsistent diagnostic outcomes.The ovarian-adnexal reporting and data system(O-RADS)aims to standardize ultrasound-based diagnosis;however,optimization of the clinical utility of O-RADS remains unclear.AIM To compare the diagnostic performance of subjective assessment and O-RADS between senior and junior radiologists in ovarian adnexal lesions.METHODS This was a retrospective study and included 364 patients with 414 ovarian-adnexal lesions(30 malignant and 384 benign),all confirmed by pathological examination.A senior radiologist and a junior radiologist independently diagnosed all lesions using subjective assessment and O-RADS,respectively.Diagnostic indices including sensitivity,specificity,and accuracy were compared,and the consistency of O-RADS classification between the two radiologists was analyzed.RESULTS For the senior radiologist,the accuracy of subjective assessment(96.6%,400/414)was significantly higher than that of O-RADS(89.1%,369/414);compared with subjective assessment,O-RADS significantly decreased specificity(97.9%vs 90.1%,χ2=20.812,P<0.001)and accuracy(χ2=17.538,P<0.001),while sensitivity showed no significant change(80.0%vs 76.7%,χ2=0.098,P=0.754).For the junior radiologist,O-RADS significantly improved sensitivity compared with subjective assessment(76.7%vs 46.7%,χ2=5.711,P=0.017),with no significant decreases in specificity(95.3%vs 97.1%,χ2=1.756,P=0.185)or accuracy(94.0%vs 93.4%,χ2=0.082,P=0.775).The O-RADS classification consistency between the senior and junior radiologist was moderate(Kappa=0.475,P<0.001).CONCLUSION Senior radiologists should prioritize subjective assessment to maximize diagnostic accuracy,while junior radiologists can significantly benefit from O-RADS to improve sensitivity in diagnosing malignant lesions.展开更多
BACKGROUND The Liver Imaging Reporting and Data System(LI-RADS)is widely used for the diagnosis of hepatocellular carcinoma,but feature scoring by radiologists is subjective and time-consuming.An urgent need exists fo...BACKGROUND The Liver Imaging Reporting and Data System(LI-RADS)is widely used for the diagnosis of hepatocellular carcinoma,but feature scoring by radiologists is subjective and time-consuming.An urgent need exists for an objective and efficient radiologist-supervised automated LI-RADS categorization system.AIM To develop an evidence-based radiologist-supervised automated LI-RADS grade 3(LR-3),4(LR-4)and 5(LR-5)categorization system(Evi-LIRADS)through quantitative feature characterization,following LI-RADS v2018.METHODS This retrospective multicenter study(April 2012-November 2022)included untreated patients with suspected hepatocellular carcinoma undergoing gadoxetic acid-enhanced magnetic resonance imaging.Lesions from center 1 were partitioned into a development set(275 lesions used for five-fold cross-validation)and an internal testing set(62 lesions).Lesions from centers 2(85 lesions)and 3(104 lesions)constituted two external testing sets.Evi-LIRADS was designed by emulating the decision-making process of radiologists through a series of image processing algorithms,to recognize nonrim arterial phase hyper-enhancement,nonperipheral washout,and enhancing capsule,which provided detailed assessments of feature locations and patterns,improving the transparency of feature classification.Based on the three major image features and the automatically segmented lesion size,LIRADS categories were assigned using LI-RADS v2018 algorithm.Feature classification was evaluated using area under the receiver operating characteristic curve.LI-RADS categorization was assessed by accuracy.RESULTS The internal dataset included 337 patients from center 1,while external datasets comprised 76 patients from center 2 and 97 patients from center 3.For feature classification,areas under the receiver operating characteristic curves were 0.975,0.898,and 0.940 for arterial phase hyper-enhancement;0.803,0.824,and 0.850 for washout;0.759,0.800,and 0.784 for capsule across three datasets.Three-class LI-RADS categorization among LR-3,LR-4 and LR-5 achieved accuracies of 80.6%,74.1%,and 77.9%,respectively,surpassing comparison methods(58.6%-69.6%).LIRADS categorization between LR-3 and combined LR-4/LR-5 achieved 95.2%,88.2%,and 90.4%accuracies for the three datasets,respectively.The visualization provided detailed feature locations and patterns.Evi-LIRADS saved an average of 21.1 seconds per patient(58.8%of the time)compared with radiologists,excluding radiologists’quality control time.CONCLUSION Following LI-RADS guidelines and radiologists’decision-making process,Evi-LIRADS was developed through quantitative feature characterization,demonstrating good accuracy,robust generalization,improved efficiency,enhanced clinical relevance,and improved transparency.展开更多
Objective The diagnostic efficacy of hybrid positron emission tomography(PET)/MRI in detecting primary prostate cancer(PCa)is limited due to the lack of a quantitative integrated analysis.A new Prostate Imaging Report...Objective The diagnostic efficacy of hybrid positron emission tomography(PET)/MRI in detecting primary prostate cancer(PCa)is limited due to the lack of a quantitative integrated analysis.A new Prostate Imaging Reporting and Data System(PI-RADS)incorporating prostate-specific membrane antigen(PSMA)PET for PET/MRI has been introduced to improve primary detection of PCa.Methods One hundred and twenty consecutive patients with high clinical suspicion of PCa were enrolled in this prospective study to assess the diagnostic performance of PSMA-adjusted PI-RADS(PAPI-RADS)using 68Ga-PSMA-11 PET/MRI.Tumor PSMA uptake was assessed semi-quantitatively using the maximum and peak standardized uptake values.The PAPI-RADS was obtained by combining tumor PSMA uptake with PI-RADS.Patients were divided into two groups:a training group(90 patients)and a validation group(30 patients).The cutoff value of PSMA intensity was determined via receiver operating characteristic analysis.PAPI-RADS was then applied to the validation group.Histopathology was used as the gold standard to verify the diagnostic efficacy.Results In the training group,PAPI-RADS detected more cases of PCa than PI-RADS.PAPI-RADS had a sensitivity of 99%,specificity of 100%,negative predictive value of 92%,and overall accuracy of 99%.PI-RADS had a sensitivity of 94%,specificity of 75%,negative predictive value of 64%,and overall accuracy of 90%.PAPI-RADS was significantly better than PI-RADS in detecting PCa(χ2=6.57,p=0.010).The external validation of this study confirmed the diagnostic efficacy of PAPI-RADS in PCa patients.Conclusion PAPI-RADS is significantly better than PI-RADS in detecting PCa.PAPI-RADS can improve the diagnostic accuracy of PCa detection,especially in patients with a PI-RADS score<3 lesions.PAPI-RADS can improve the accuracy of PCa diagnosis and avoid unnecessary biopsies.展开更多
Objective This study aimed to assess the local staging of bladder tumors in patients utilizing preoperative multiparametric MRI(mpMRI)and to demonstrate the clinical efficacy of this method through a comparative analy...Objective This study aimed to assess the local staging of bladder tumors in patients utilizing preoperative multiparametric MRI(mpMRI)and to demonstrate the clinical efficacy of this method through a comparative analysis with corresponding histopathological findings.Methods Between November 2020 and April 2022,63 patients with a planned cystoscopy and a preliminary or previous diagnosis of bladder tumor were included.All participants underwent mpMRI,and Vesical Imaging Reporting and Data System(VI-RADS)criteria were applied to assess the recorded images.Subsequently,obtained biopsies were histopathologically examined and compared with radiological findings.Results Of the 63 participants,60 were male,and three were female.Categorizing tumors with a VI-RADS score of>3 as muscle invasive,84%were radiologically classified as having an invasive bladder tumor.However,histopathological results indicated invasive bladder tumors in 52%of cases.Sensitivity of the VI-RADS score was 100%;specificity was 23%;the negative predictive value was 100%;and the positive predictive value was 62%.Conclusion The scoring system obtained through mpMRI,VI-RADS,proves to be a successful method,particularly in determining the absence of muscle invasion in bladder cancer.Its efficacy in detecting muscle invasion in bladder tumors could be further enhanced with additional studies,suggesting potential for increased diagnostic efficiency through ongoing research.The VI-RADS could enhance the selection of patients eligible for accurate diagnosis and treatment.展开更多
BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the ris...BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the risk of misdiagnosing intrahepatic cholangiocarcinoma(ICC).The introduction of CEUS Liver Imaging Reporting and Data System(CEUS LI-RADS)might overcome this limitation.Even though data from the literature seems promising,its reliability in real-life context has not been well-established yet.AIM To test the accuracy of CEUS LI-RADS for correctly diagnosing HCC and ICC in cirrhosis.METHODS CEUS LI-RADS class was retrospectively assigned to 511 nodules identified in 269 patients suffering from liver cirrhosis.The diagnostic standard for all nodules was either biopsy(102 nodules)or CT/MRI(409 nodules).Common diagnostic accuracy indexes such as sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were assessed for the following associations:CEUS LR-5 and HCC;CEUS LR-4 and 5 merged class and HCC;CEUS LR-M and ICC;and CEUS LR-3 and malignancy.The frequency of malignant lesions in CEUS LR-3 subgroups with different CEUS patterns was also determined.Inter-rater agreement for CEUS LI-RADS class assignment and for major CEUS pattern identification was evaluated.RESULTS CEUS LR-5 predicted HCC with a 67.6%sensitivity,97.7%specificity,and 99.3%PPV(P<0.001).The merging of LR-4 and 5 offered an improved 93.9%sensitivity in HCC diagnosis with a 94.3%specificity and 98.8%PPV(P<0.001).CEUS LR-M predicted ICC with a 91.3%sensitivity,96.7%specificity,and 99.6%NPV(P<0.001).CEUS LR-3 predominantly included benign lesions(only 28.8%of malignancies).In this class,the hypo-hypo pattern showed a much higher rate of malignant lesions(73.3%)than the iso-iso pattern(2.6%).Inter-rater agreement between internal raters for CEUS-LR class assignment was almost perfect(n=511,k=0.94,P<0.001),while the agreement among raters from separate centres was substantial(n=50,k=0.67,P<0.001).Agreement was stronger for arterial phase hyperenhancement(internal k=0.86,P<2.7×10-214;external k=0.8,P<0.001)than washout(internal k=0.79,P<1.6×10-202;external k=0.71,P<0.001).CONCLUSION CEUS LI-RADS is effective but can be improved by merging LR-4 and 5 to diagnose HCC and by splitting LR-3 into two subgroups to differentiate iso-iso nodules from other patterns.展开更多
Prostate cancer (PCa) is one of the most common cancers among men globally. The authors aimed to evaluate the ability of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) to classify men with P...Prostate cancer (PCa) is one of the most common cancers among men globally. The authors aimed to evaluate the ability of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) to classify men with PCa, clinically significant PCa (CSPCa), or no PCa, especially among those with serum total prostate-specific antigen (tPSA) levels in the "gray zone" (4-10 ng ml-1). A total of 308 patients (355 lesions) were enrolled in this study. Diagnostic efficiency was determined. Univariate and multivariate analyses, receiver operating characteristic curve analysis, and decision curve analysis were performed to determine and compare the predictors of PCa and CSPCa. The results suggested that PI-RADS v2, tPSA, and prostate-specific antigen density (PSAD) were independent predictors of PCa and CSPCa. A PI-RADS v2 score L≥4 provided high negative predictive values (91.39% for PCa and 95.69% for CSPCa). A model of PI-RADS combined with PSA and PSAD helped to define a high-risk group (PI-RADS score = 5 and PSAD L≥0 15 ng ml-1 cm-3, with tPSA in the gray zone, or PI-RADS score L≥4 with high tPSA level) with a detection rate of 96.1% for PCa and 93.0% for CSPCa while a low-risk group with a detection rate of 6.1% for PCa and 2.2% for CSPCa. It was concluded that the PI-RADS v2 could be used as a reliable and independent predictor of PCa and CSPCa. The combination of PI-RADS v2 score with PSA and PSAD could be helpful in the prediction and diagnosis of PCa and CSPCa and, thus, may help in preventing unnecessary invasive procedures.展开更多
BACKGROUND The 2018 ovarian-adnexal reporting and data system(O-RADS)guidelines are aimed at providing a system for consistent reports and risk stratification for ovarian lesions found on ultrasound.It provides key ch...BACKGROUND The 2018 ovarian-adnexal reporting and data system(O-RADS)guidelines are aimed at providing a system for consistent reports and risk stratification for ovarian lesions found on ultrasound.It provides key characteristics and findings for lesions,a lexicon of descriptors to communicate findings,and risk characterization and associated follow-up recommendation guidelines.However,the ORADS guidelines have not been validated in North American institutions or amongst less experienced readers.AIM To evaluate the diagnostic accuracy and inter-reader reliability of ultrasound ORADS risk stratification amongst less experienced readers in a North American institution with and without pre-test training.METHODS A single-center retrospective study was performed using 100 ovarian/adnexal lesions of varying O-RADS scores.Of these cases,50 were allotted to a training cohort and 50 to a testing cohort via a non-randomized group selection process in order to approximately equal distribution of O-RADS categories both within and between groups.Reference standard O-RADS scores were established through consensus of three fellowship-trained body imaging radiologists.Three PGY-4 residents were independently evaluated for diagnostic accuracy and inter-reader reliability with and without pre-test O-RADS training.Sensitivity,specificity,positive predictive value,negative predictive value(NPV),and area under the curve(AUC)were used to measure accuracy.Fleiss kappa and weighted quadratic(pairwise)kappa values were used to measure inter-reader reliability.Statistical significance was P<0.05.RESULTS Mean patient age was 40±16 years with lesions ranging from 1.2 to 22.5 cm.Readers demonstrated excellent specificities(85%-100%pre-training and 91%-100%post-training)and NPVs(89%-100%pre-training and 91-100%post-training)across the O-RADS categories.Sensitivities were variable(55%-100%pre-training and 64%-100%post-training)with malignant ORADS 4 and 5 Lesions pre-training and post-training AUC values of 0.87-0.95 and 0.94-098,respectively(P<0.001).Nineteen of 22(86%)misclassified cases in pre-training were related to mischaracterization of dermoid features or wall/septation morphology.Fifteen of 17(88%)of posttraining misclassified cases were related to one of these two errors.Fleiss kappa inter-reader reliability was‘good’and pairwise inter-reader reliability was‘very good’with pre-training and post-training assessment(k=0.76 and 0.77;and k=0.77-0.87 and 0.85-0.89,respectively).CONCLUSION Less experienced readers in North America achieved excellent specificities and AUC values with very good pairwise inter-reader reliability.They may be subject to misclassification of potentially malignant lesions,and specific training around dermoid features and smooth vs irregular inner wall/septation morphology may improve sensitivity.展开更多
Hepatocellular carcinoma(HCC)is the sixth most common cancer.The main risk factors associated with HCC development include hepatitis B virus,hepatitis C virus,alcohol consumption,aflatoxin B1,and nonalcoholic fatty li...Hepatocellular carcinoma(HCC)is the sixth most common cancer.The main risk factors associated with HCC development include hepatitis B virus,hepatitis C virus,alcohol consumption,aflatoxin B1,and nonalcoholic fatty liver disease.However,hepatocarcinogenesis is a complex multistep process.Various factors lead to hepatocyte malignant transformation and HCC development.Diagnosis and surveillance of HCC can be made with the use of liver ultrasound(US)every 6 mo.However,the sensitivity of this imaging method to detect HCC in a cirrhotic liver is limited,due to the abnormal liver parenchyma.Computed tomography(CT)and magnetic resonance imaging(MRI)are considered to be most useful tools for at-risk patients or patients with inadequate US.Liver biopsy is still used for diagnosis and prognosis of HCC in specific nodules that cannot be definitely characterized as HCC by imaging.Recently the American College of Radiology designed the Liver Imaging Reporting and Data System(LI-RADS),which is a comprehensive system for standardized interpretation of CT and MRI liver examinations that was first proposed in 2011.In 2018,it was integrated into the American Association for the Study of Liver Diseases guidance statement for HCC.LI-RADS is designed to ensure high sensitivity,precise categorization,and high positive predictive value for the diagnosis of HCC and is applied to“highrisk populations”according to specific criteria.Most importantly LI-RADS criteria achieved international collaboration and consensus among liver experts around the world on the best practices for caring for patients with or at risk for HCC.展开更多
BACKGROUND Hepatocellular carcinoma is the most common primary liver malignancy.From the results of previous studies,Liver Imaging Reporting and Data System(LIRADS)on contrast-enhanced ultrasound(CEUS)has shown satisf...BACKGROUND Hepatocellular carcinoma is the most common primary liver malignancy.From the results of previous studies,Liver Imaging Reporting and Data System(LIRADS)on contrast-enhanced ultrasound(CEUS)has shown satisfactory diagnostic value.However,a unified conclusion on the interobserver stability of this innovative ultrasound imaging has not been determined.The present metaanalysis examined the interobserver agreement of CEUS LI-RADS to provide some reference for subsequent related research.AIM To evaluate the interobserver agreement of LI-RADS on CEUS and analyze the sources of heterogeneity between studies.METHODS Relevant papers on the subject of interobserver agreement on CEUS LI-RADS published before March 1,2020 in China and other countries were analyzed.The studies were filtered,and the diagnostic criteria were evaluated.The selected references were analyzed using the“meta”and“metafor”packages of R software version 3.6.2.RESULTS Eight studies were ultimately included in the present analysis.Meta-analysis results revealed that the summary Kappa value of included studies was 0.76[95%confidence interval,0.67-0.83],which shows substantial agreement.Higgins I2 statistics also confirmed the substantial heterogeneity(I2=91.30%,95%confidence interval,85.3%-94.9%,P<0.01).Meta-regression identified the variables,including the method of patient enrollment,method of consistency testing,and patient race,which explained the substantial study heterogeneity.CONCLUSION CEUS LI-RADS demonstrated overall substantial interobserver agreement,but heterogeneous results between studies were also obvious.Further clinical investigations should consider a modified recommendation about the experimental design.展开更多
Hepatocellular carcinoma(HCC)is a leading cause of morbidity and mortality worldwide,with rising clinical and economic burden as incidence increases.There are a multitude of evolving treatment options,including locore...Hepatocellular carcinoma(HCC)is a leading cause of morbidity and mortality worldwide,with rising clinical and economic burden as incidence increases.There are a multitude of evolving treatment options,including locoregional therapies which can be used alone,in combination with each other,or in combination with systemic therapy.These treatment options have shown to be effective in achieving remission,controlling tumor progression,improving disease free and overall survival in patients who cannot undergo resection and providing a bridge to transplant by debulking tumor burden to downstage patients.Following locoregional therapy(LRT),it is crucial to provide treatment response assessment to guide management and liver transplant candidacy.Therefore,Liver Imaging Reporting and Data Systems(LI-RADS)Treatment Response Algorithm(TRA)was created to provide a standardized assessment of HCC following LRT.LIRADS TRA provides a step by step approach to evaluate each lesion independently for accurate tumor assessment.In this review,we provide an overview of different locoregional therapies for HCC,describe the expected post treatment imaging appearance following treatment,and review the LI-RADS TRA with guidance for its application in clinical practice.Unique to other publications,we will also review emerging literature supporting the use of LI-RADS for assessment of HCC treatment response after LRT.展开更多
Objective:Vesical Imaging Reporting and Data System(VIRADS)score was developed to standardize the reporting and staging of bladder tumors on pre-operative multiparametric magnetic resonance imaging.It helps in avoidin...Objective:Vesical Imaging Reporting and Data System(VIRADS)score was developed to standardize the reporting and staging of bladder tumors on pre-operative multiparametric magnetic resonance imaging.It helps in avoiding unnecessary repeat transurethral resection of bladder tumor in high-risk non-muscle-invasive bladder cancer patients.This study was done to determine the validity of VIRADS score prospectively for the diagnosis of muscleinvasive bladder cancer.Methods:This study was conducted from March 2019 to March 2020 at Sawai Man Singh Medical College and Hospital,Jaipur,Rajasthan,India.Patients admitted with the provisional diagnosis of bladder tumor were included as participants.All these patients underwent a 3 Tesla mpMRI to obtain a VIRADS score before they underwent transurethral resection of bladder tumor and these data were analyzed to evaluate the correlation of pre-operative VIRADS score with mus-cle invasiveness of the tumor in final biopsy report.Results:A cut-off of VIRADS≥4 for prediction of detrusor muscle invasion yielded a sensitivity of 79.4%,specificity of 94.2%,positive predictive value of 90.0%,negative predictive value of 87.5%,and diagnostic accuracy of 86.4%.A cut off of VIRADS≥3 for prediction of detrusor muscle invasion yielded a sensitivity of 91.2%,specificity of 78.8%,positive predictive value of 73.8%,negative predictive value of 93.2%,and accuracy of 83.7%.The receiver operating curve showed the area under the curve to be 0.922(95%confidence interval:0.862e0.983).Conclusion:VIRADS score appears to be an excellent and effective pre-operative radiological tool for the prediction of detrusor muscle invasion in bladder cancer.展开更多
BACKGROUND The American College of Radiology Thyroid Imaging Reporting and Data System(ACR TI-RADS)was introduced to standardize the ultrasound characterization of thyroid nodules.Studies have shown that ACR-TIRADS re...BACKGROUND The American College of Radiology Thyroid Imaging Reporting and Data System(ACR TI-RADS)was introduced to standardize the ultrasound characterization of thyroid nodules.Studies have shown that ACR-TIRADS reduces unnecessary biopsies and improves consistency of imaging recommendations.Despite its widespread adoption,there are few studies to date assessing the inter-reader agreement amongst radiology trainees with limited ultrasound experience.We hypothesize that in PGY-4 radiology residents with no prior exposure to ACR TIRADS,a statistically significant improvement in inter-reader reliability can be achieved with a one hour training session.AIM To evaluate the inter-reader agreement of radiology residents in using ACR TIRADS before and after training.METHODS A single center retrospective cohort study evaluating 50 thyroid nodules in 40 patients of varying TI-RADS levels was performed.Reference standard TI-RADS scores were established through a consensus panel of three fellowship-trained staff radiologists with between 1 and 14 years of clinical experience each.Three PGY-4 radiology residents(trainees)were selected as blinded readers for this study.Each trainee had between 4 to 5 mo of designated ultrasound training.No trainee had received specialized TI-RADS training prior to this study.Each of the readers independently reviewed the 50 testing cases and assigned a TI-RADS score to each case before and after TI-RADS training performed 6 wk apart.Fleiss kappa was used to measure the pooled inter-reader agreement.The relative diagnostic performance of readers,pre-and post-training,when compared against the reference standard.RESULTS There were 33 females and 7 males with a mean age of 56.6±13.6 years.The mean nodule size was 19±14 mm(range from 5 to 63 mm).A statistically significant superior inter-reader agreement was found on the post-training assessment compared to the pre-training assessment for the following variables:1.“Shape”(k of 0.09[slight]pre-training vs 0.67[substantial]post-training,P<0.001),2.“Echogenic foci”(k of 0.28[fair]pre-training vs 0.45[moderate]post-training,P=0.004),3.‘TI-RADS level’(k of 0.14[slight]pre-training vs 0.36[fair]post-training,P<0.001)and 4.‘Recommendations’(k of 0.36[fair]pre-training vs 0.50[moderate]post-training,P=0.02).No significant differences between the preand post-training assessments were found for the variables'composition','echogenicity'and'margins'.There was a general trend towards improved pooled sensitivity with TI-RADS levels 1 to 4 for the post-training assessment while the pooled specificity was relatively high(76.6%-96.8%)for all TI-RADS level.CONCLUSION Statistically significant improvement in inter-reader agreement in the assigning TI-RADS level and recommendations after training is observed.Our study supports the use of dedicated ACR TI-RADS training in radiology residents.展开更多
BACKGROUND Collision tumor are neoplasms,including two histologically distinct tumors that coexist in the same mass without histological admixture.The incidence of collision tumor is low and is rare clinically.AIM To ...BACKGROUND Collision tumor are neoplasms,including two histologically distinct tumors that coexist in the same mass without histological admixture.The incidence of collision tumor is low and is rare clinically.AIM To investigate ultrasound images and application of ovarian-adnexal reporting and data system(O-RADS)to evaluate the risk and pathological characteristics of ovarian collision tumor.METHODS This study retrospectively analyzed 17 cases of ovarian collision tumor diagnosed pathologically from January 2020 to December 2023.All clinical features,ultrasound images and histopathological features were collected and analyzed.The O-RADS score was used for classification.The O-RADS score was determined by two senior doctors in the gynecological ultrasound group.Lesions with O-RADS score of 1-3 were classified as benign tumors,and lesions with O-RADS score of 4 or 5 were classified as malignant tumors.RESULTS There were 17 collision tumors detected in 16 of 6274 patients who underwent gynecological surgery.The average age of 17 women with ovarian collision tumor was 36.7 years(range 20-68 years),in whom,one occurred bilaterally and the rest occurred unilaterally.The average tumor diameter was 10 cm,of which three were 2-5 cm,11 were 5-10 cm,and three were>10 cm.Five(29.4%)tumors with O-RADS score 3 were endometriotic cysts with fibroma/serous cystadenoma,and unilocular or multilocular cysts contained a small number of parenchymal components.Eleven(64.7%)tumors had an O-RADS score of 4,including two in category 4A,six in category 4B,and three in category 4C;all of which were multilocular cystic tumors with solid components or multiple papillary components.One(5.9%)tumor had an O-RADS score of 5.This case was a solid mass,and a small amount of pelvic effusion was detected under ultrasound.The pathology was high-grade serous cystic cancer combined with cystic mature teratoma.There were nine(52.9%)tumors with elevated serum carbohydrate antigen(CA)125 and two(11.8%)with elevated serum CA19-9.Histological and pathological results showed that epithelial-cell-derived tumors combined with other tumors were the most common,which was different from previous results.CONCLUSION The ultrasound images of ovarian collision tumor have certain specificity,but diagnosis by preoperative ultrasound is difficult.The combination of epithelial and mesenchymal cell tumors is one of the most common types of ovarian collision tumor.The O-RADS score of ovarian collision tumor is mostly≥4,which can sensitively detect malignant tumors.展开更多
A series of quality control(QC) procedures were performed on a gauge-based global daily precipitation dataset from the Global Telecommunication System(GTS) for the period 1980-2009.A new global daily precipitation(NGD...A series of quality control(QC) procedures were performed on a gauge-based global daily precipitation dataset from the Global Telecommunication System(GTS) for the period 1980-2009.A new global daily precipitation(NGDP) dataset was constructed by applying those QC procedures to eliminate erroneous records.The NGDP dataset was evaluated using the NOAA Climate Prediction Center Merged Analysis of Precipitation(CMAP) and the Global Precipitation Climatology Project(GPCP) precipitation datasets.The results showed that the frequency distribution and spatial distribution pattern of NGDP had a nice match with those from the CMAP and GPCP datasets.The global mean correlation coefficients with the CMAP and GPCP data increased from 0.24 for original GTS precipitation data to about 0.70 for NGDP data.Correspondingly,the root mean square errors(RMSE) decreased from 12 mm per day to 1 mm per day.The interannual variabilities of NGDP monthly precipitation are consistent with the CMAP and GPCP datasets in Asia.Meanwhile,the seasonal variabilities for most land areas on the Earth of NGDP dataset are also consistent with the CMAP and GPCP precipitation products.展开更多
Pedestrian safety in China is an important but largely neglected issue, in part due to the substantial under-reporting within police data. In this study we aimed to examine changes in pedestrian fatality between 2006 ...Pedestrian safety in China is an important but largely neglected issue, in part due to the substantial under-reporting within police data. In this study we aimed to examine changes in pedestrian fatality between 2006 and 2010 in China using non-police reported data. A multi-year study was conducted based on the mortality data during 2006-2010 from the Disease Surveillance Points (DSP) data in China. Between 2006 and 2010, the crude pedestrian mortality increased from 7.0 to 10.5 per 100 000 populations. Annual pedestrian mortality from DSP data was 13 times in 2006 and 55 times in 2010 mortality for pedestrians and passengers from police-reported data in the corresponding years. After controlling for sex, age,展开更多
BACKGROUND Prostate cancer(PCa)is the second most common malignancy and the fifth leading cause of cancer death among men worldwide.Magnetic resonance imaging(MRI)-based radiomics has emerged as a promising tool for d...BACKGROUND Prostate cancer(PCa)is the second most common malignancy and the fifth leading cause of cancer death among men worldwide.Magnetic resonance imaging(MRI)-based radiomics has emerged as a promising tool for diagnosing PCa,but its true potential remains a subject of ongoing debate.AIM To evaluate the diagnostic performance of MRI-based radiomics for PCa detection and compare it with the Prostate Imaging Reporting and Data System(PI-RADS)score.METHODS A systematic search of EMBASE,Web of Science,and PubMed was conducted up to August 18,2025.Pooled sensitivity,specificity,and area under the curve were calculated.Subgroup analyses were performed to evaluate heterogeneity.Additionally,the diagnostic accuracy of MRI-based radiomics was compared with that of the PI-RADS score.Methodological quality was evaluated via the Radiomics Quality Score.RESULTS This meta-analysis included 49 studies encompassing 10512 patients.MRI-based radiomics demonstrated a pooled sensitivity of 0.84[95%confidence interval(CI):0.80-0.87],specificity of 0.78(95%CI:0.72-0.84),and area under the curve of 0.88(95%CI:0.85-0.91).Deek’s funnel plot asymmetry test indicated no publication bias.Subgroup analyses revealed that multiparametric MRI-based radiomics is more effective in diagnosing clinically significant PCa and that 3D-based radiomics outperforms 2D approaches.In a head-to-head comparison,the MRI-radiomics model yielded a numerically greater pooled diagnostic value(0.85;95%CI:0.82-0.88)than did the PI-RADS score(0.71;95%CI:0.63-0.77)(P=0.07).The mean Radiomics Quality Score was 18.2(50.6%of the maximum score).All studies reported performing cut-off analyses,22 studies(44.9%)addressed biological correlates,and all claimed code or data accessibility.CONCLUSION MRI-based radiomics is a reliable tool for detecting PCa,with 3D radiomic models showing greater effectiveness than 2D approaches in terms of sensitivity(0.85 vs 0.79).Radiomics also offers superior diagnostic accuracy for clinically significant PCa compared with the PI-RADS score,underscoring its potential in improving PCa diagnostics.展开更多
Lead (Pb) isotopes can provide key information to address fundamental geologic problems related to the formation and evolution of rocky planets. The Pb isotope system supports a diversity of applications, as it provid...Lead (Pb) isotopes can provide key information to address fundamental geologic problems related to the formation and evolution of rocky planets. The Pb isotope system supports a diversity of applications, as it provides access to information on magma sources as well as geologic age. Consequently, a wide range of analytical techniques, data validation and interpretation strategies have been advanced across a range of Pb isotope studies. Given the multiple different Pb isotope pairs, reflecting different decay rates and ultimate parental isotope concentrations, Pb isotopes have been viewed as one of the more challenging isotope systems to comprehend. Here we provide an overview of the various analytical and interpretative approaches, for this system, and highlight their respective strengths in the context of applications, such as magma source tracking and model age determination. A discussion of different methods to determine magma source parameters (e.g., U/Pb ratio and model age) is presented, along with recommendations for data validation and reporting. A checklist for recommended data and metadata to report for Pb isotopes is provided. The aim of this contribution is to provide a framework that enables a robust interpretation of Pb isotope signatures, promoting data transparency and comparison across different analytical approaches.展开更多
Purpose: The objective of the study was to design and implement an electronic synoptic report for thyroid sonography that incorporates the thyroid imaging reporting and data system (TIRADS) and assess potential for re...Purpose: The objective of the study was to design and implement an electronic synoptic report for thyroid sonography that incorporates the thyroid imaging reporting and data system (TIRADS) and assess potential for reducing unnecessary fine needle aspiration biopsies (FNAB) of thyroid nodules. Methods: The electronic synoptic report was developed using a relational database based on elements from TIRADS and a multidisciplinary consensus statement for thyroid reporting. A retrospective analysis of 138 patients with previously reported thyroid sonographic exams was evaluated for the presence of these elements. The electronic synoptic report calculates the TIRADS score and generates a formal report. Using the TIRADS score the potential decrease in unnecessary FNAB was estimated. Results: Key TIRADS elements were variously reported ranging from 43% for the thyroid nodule’s architecture as solid or cystic. Thyroid nodule echogenicity and calcification was commented in 27% and 23%, respectively. Other features of the TIRADS score were commented in 0% to 8% of the official reports. Estimated reduction for potentially reduced need for FNAB was 34.5%. Conclusions: This study is the first implementation of synoptic reporting using a relational database for sonography of thyroid nodules. Implementation of an electronic standardized synoptic reporting system may facilitate more accurate, and more comprehensive reporting for thyroid ultrasound scanning of thyroid nodules. The use of TIRADS was estimated to be able to potentially reduce the need for FNAB which was significant.展开更多
BACKGROUND Currently,only tumors classified as LR-5 are considered definitive hepatocellular carcinoma(HCC),and no further pathologic confirmation is required to initiate therapy.Previous studies have shown that the s...BACKGROUND Currently,only tumors classified as LR-5 are considered definitive hepatocellular carcinoma(HCC),and no further pathologic confirmation is required to initiate therapy.Previous studies have shown that the sensitivity of LR-5 is modest,and lesions enhanced by gadoxetic acid(Gd-EOB-DTPA)may exhibit lower sensitivity than those enhanced by Gd-DTPA.AIM To identify malignant ancillary features(AFs)that can independently and significantly predict HCC in Liver Imaging Reporting and Data System version 2018,and to develop modified LR-5 criteria to improve diagnostic performance on Gd-EOB-DTPA-enhanced magnetic resonance imaging.METHODS Imaging data from patients with HCC risk factors who underwent abdominal Gd-EOB-DTPA-enhanced magnetic resonance imaging were collected.Univariate and multivariate logistic regression analyses were performed to determine AFs that could independently and significantly predict HCC.The modified LR-5 criteria involved reclassifying LR-4/LR-3 lesions based on major features combined with independently significant AFs for HCC,or by substituting threshold growth with significant AFs.McNemar's test was used to compare the diagnostic performance of the modified LR-5 criteria.RESULTS A total of 244 lesions from 216 patients were included.Transitional phase hypointensity,mild-moderate T2 hyperintensity,and fat in mass(more than adjacent liver)were identified as significant independent predictors of HCC.Using the modified LR-5 criteria(e.g.,LR-5-M1:LR-4+transitional phase hypointensity;LR-5-M4:LR-5 by transitional phase hypointensity instead of threshold growth;LR-5-M5:LR-5 by mild-moderate T2 hyperintensity instead of threshold growth;LR-5-M8:LR-3/LR-4+any two features of transitional phase hypointensity/mild-moderate T2 hyperintensity/fat in mass),sensitivities were significantly increased(88.5%-89.1%)compared to the standard LR-5(60.6%;all P values0.05).The LR-5-M8 criterion achieved the highest sensitivity.CONCLUSION Mild-moderate T2 hyperintensity,transitional phase hypointensity,and fat in mass are independent and significant predictors of HCC malignant AFs.The modified LR-5 criteria can improve sensitivity without significantly reducing specificity.展开更多
基金the National Natural Science Foundation of China(No.71201172)
摘要A cluster-based organization with two phases to separate priority calculation and network activity operations is developed. In the election-state phase, clusters are organized by those nodes with sufficient residual energy level(REL) that are distributed as evenly as possible in the network. For each network round, each node decides its role(such as, cluster header(CH) or a normal node) and its priority level for activity operation. The priority level also affects the active/sleep scheduling in the node. In the steady-state phase, the positive priority levels of active nodes determine their activity order to avoid transmission collision, and to reduce redundant data transmission and sensing coverage. Since the data reporting to the sink is usually performed by a CH delivery chain, subsidiary CHs are selected to assist with data delivery and to share the loading of CHs. The formulae for computing priority levels are analyzed and verified by the examples with valid parameters. The experimental results show that the two phases efficiently consume node energy and achieve energy savings.
基金Supported by Key Specialty of Changning District,Shanghai,China,No.20231004Key Science-Technology Project of Songjiang District Committee on Science and Technology,No.2023SJKWGG042.
摘要BACKGROUND The diagnosis of ovarian-adnexal lesions is challenging due to the variability in radiologist experience,which may lead to inconsistent diagnostic outcomes.The ovarian-adnexal reporting and data system(O-RADS)aims to standardize ultrasound-based diagnosis;however,optimization of the clinical utility of O-RADS remains unclear.AIM To compare the diagnostic performance of subjective assessment and O-RADS between senior and junior radiologists in ovarian adnexal lesions.METHODS This was a retrospective study and included 364 patients with 414 ovarian-adnexal lesions(30 malignant and 384 benign),all confirmed by pathological examination.A senior radiologist and a junior radiologist independently diagnosed all lesions using subjective assessment and O-RADS,respectively.Diagnostic indices including sensitivity,specificity,and accuracy were compared,and the consistency of O-RADS classification between the two radiologists was analyzed.RESULTS For the senior radiologist,the accuracy of subjective assessment(96.6%,400/414)was significantly higher than that of O-RADS(89.1%,369/414);compared with subjective assessment,O-RADS significantly decreased specificity(97.9%vs 90.1%,χ2=20.812,P<0.001)and accuracy(χ2=17.538,P<0.001),while sensitivity showed no significant change(80.0%vs 76.7%,χ2=0.098,P=0.754).For the junior radiologist,O-RADS significantly improved sensitivity compared with subjective assessment(76.7%vs 46.7%,χ2=5.711,P=0.017),with no significant decreases in specificity(95.3%vs 97.1%,χ2=1.756,P=0.185)or accuracy(94.0%vs 93.4%,χ2=0.082,P=0.775).The O-RADS classification consistency between the senior and junior radiologist was moderate(Kappa=0.475,P<0.001).CONCLUSION Senior radiologists should prioritize subjective assessment to maximize diagnostic accuracy,while junior radiologists can significantly benefit from O-RADS to improve sensitivity in diagnosing malignant lesions.
基金Supported by National Natural Science Foundation of China,No.82271956Shanghai Municipal Science and Technology Explorer Project,No.23TS1400500.
摘要BACKGROUND The Liver Imaging Reporting and Data System(LI-RADS)is widely used for the diagnosis of hepatocellular carcinoma,but feature scoring by radiologists is subjective and time-consuming.An urgent need exists for an objective and efficient radiologist-supervised automated LI-RADS categorization system.AIM To develop an evidence-based radiologist-supervised automated LI-RADS grade 3(LR-3),4(LR-4)and 5(LR-5)categorization system(Evi-LIRADS)through quantitative feature characterization,following LI-RADS v2018.METHODS This retrospective multicenter study(April 2012-November 2022)included untreated patients with suspected hepatocellular carcinoma undergoing gadoxetic acid-enhanced magnetic resonance imaging.Lesions from center 1 were partitioned into a development set(275 lesions used for five-fold cross-validation)and an internal testing set(62 lesions).Lesions from centers 2(85 lesions)and 3(104 lesions)constituted two external testing sets.Evi-LIRADS was designed by emulating the decision-making process of radiologists through a series of image processing algorithms,to recognize nonrim arterial phase hyper-enhancement,nonperipheral washout,and enhancing capsule,which provided detailed assessments of feature locations and patterns,improving the transparency of feature classification.Based on the three major image features and the automatically segmented lesion size,LIRADS categories were assigned using LI-RADS v2018 algorithm.Feature classification was evaluated using area under the receiver operating characteristic curve.LI-RADS categorization was assessed by accuracy.RESULTS The internal dataset included 337 patients from center 1,while external datasets comprised 76 patients from center 2 and 97 patients from center 3.For feature classification,areas under the receiver operating characteristic curves were 0.975,0.898,and 0.940 for arterial phase hyper-enhancement;0.803,0.824,and 0.850 for washout;0.759,0.800,and 0.784 for capsule across three datasets.Three-class LI-RADS categorization among LR-3,LR-4 and LR-5 achieved accuracies of 80.6%,74.1%,and 77.9%,respectively,surpassing comparison methods(58.6%-69.6%).LIRADS categorization between LR-3 and combined LR-4/LR-5 achieved 95.2%,88.2%,and 90.4%accuracies for the three datasets,respectively.The visualization provided detailed feature locations and patterns.Evi-LIRADS saved an average of 21.1 seconds per patient(58.8%of the time)compared with radiologists,excluding radiologists’quality control time.CONCLUSION Following LI-RADS guidelines and radiologists’decision-making process,Evi-LIRADS was developed through quantitative feature characterization,demonstrating good accuracy,robust generalization,improved efficiency,enhanced clinical relevance,and improved transparency.
基金supported by Jiangsu Provincial Medical Key Discipline Cultivation Unit(JSDW202247)Jiangsu Provincial Key Research and Development Special Fund(BE2017612)+3 种基金Nanjing Medical and Health International Joint Research and Development Project(201911042)General Project of Science and Technology Development Fund of Nanjing Medical University(NMUB2019154)National Natural Science Foundation of China(82003532),Nuclear Medicine Laboratory Open Project(2021HYX009)the second round of Nanjing Clinical Medical Center“Nanjing Nuclear Medicine Center”.All funding was awarded to Wang F.
摘要Objective The diagnostic efficacy of hybrid positron emission tomography(PET)/MRI in detecting primary prostate cancer(PCa)is limited due to the lack of a quantitative integrated analysis.A new Prostate Imaging Reporting and Data System(PI-RADS)incorporating prostate-specific membrane antigen(PSMA)PET for PET/MRI has been introduced to improve primary detection of PCa.Methods One hundred and twenty consecutive patients with high clinical suspicion of PCa were enrolled in this prospective study to assess the diagnostic performance of PSMA-adjusted PI-RADS(PAPI-RADS)using 68Ga-PSMA-11 PET/MRI.Tumor PSMA uptake was assessed semi-quantitatively using the maximum and peak standardized uptake values.The PAPI-RADS was obtained by combining tumor PSMA uptake with PI-RADS.Patients were divided into two groups:a training group(90 patients)and a validation group(30 patients).The cutoff value of PSMA intensity was determined via receiver operating characteristic analysis.PAPI-RADS was then applied to the validation group.Histopathology was used as the gold standard to verify the diagnostic efficacy.Results In the training group,PAPI-RADS detected more cases of PCa than PI-RADS.PAPI-RADS had a sensitivity of 99%,specificity of 100%,negative predictive value of 92%,and overall accuracy of 99%.PI-RADS had a sensitivity of 94%,specificity of 75%,negative predictive value of 64%,and overall accuracy of 90%.PAPI-RADS was significantly better than PI-RADS in detecting PCa(χ2=6.57,p=0.010).The external validation of this study confirmed the diagnostic efficacy of PAPI-RADS in PCa patients.Conclusion PAPI-RADS is significantly better than PI-RADS in detecting PCa.PAPI-RADS can improve the diagnostic accuracy of PCa detection,especially in patients with a PI-RADS score<3 lesions.PAPI-RADS can improve the accuracy of PCa diagnosis and avoid unnecessary biopsies.
摘要Objective This study aimed to assess the local staging of bladder tumors in patients utilizing preoperative multiparametric MRI(mpMRI)and to demonstrate the clinical efficacy of this method through a comparative analysis with corresponding histopathological findings.Methods Between November 2020 and April 2022,63 patients with a planned cystoscopy and a preliminary or previous diagnosis of bladder tumor were included.All participants underwent mpMRI,and Vesical Imaging Reporting and Data System(VI-RADS)criteria were applied to assess the recorded images.Subsequently,obtained biopsies were histopathologically examined and compared with radiological findings.Results Of the 63 participants,60 were male,and three were female.Categorizing tumors with a VI-RADS score of>3 as muscle invasive,84%were radiologically classified as having an invasive bladder tumor.However,histopathological results indicated invasive bladder tumors in 52%of cases.Sensitivity of the VI-RADS score was 100%;specificity was 23%;the negative predictive value was 100%;and the positive predictive value was 62%.Conclusion The scoring system obtained through mpMRI,VI-RADS,proves to be a successful method,particularly in determining the absence of muscle invasion in bladder cancer.Its efficacy in detecting muscle invasion in bladder tumors could be further enhanced with additional studies,suggesting potential for increased diagnostic efficiency through ongoing research.The VI-RADS could enhance the selection of patients eligible for accurate diagnosis and treatment.
基金Supported by the Fondazione di Sardegna,No.FDS2019VIDILIthe University of Sassari,No.FAR2019.
摘要BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the risk of misdiagnosing intrahepatic cholangiocarcinoma(ICC).The introduction of CEUS Liver Imaging Reporting and Data System(CEUS LI-RADS)might overcome this limitation.Even though data from the literature seems promising,its reliability in real-life context has not been well-established yet.AIM To test the accuracy of CEUS LI-RADS for correctly diagnosing HCC and ICC in cirrhosis.METHODS CEUS LI-RADS class was retrospectively assigned to 511 nodules identified in 269 patients suffering from liver cirrhosis.The diagnostic standard for all nodules was either biopsy(102 nodules)or CT/MRI(409 nodules).Common diagnostic accuracy indexes such as sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were assessed for the following associations:CEUS LR-5 and HCC;CEUS LR-4 and 5 merged class and HCC;CEUS LR-M and ICC;and CEUS LR-3 and malignancy.The frequency of malignant lesions in CEUS LR-3 subgroups with different CEUS patterns was also determined.Inter-rater agreement for CEUS LI-RADS class assignment and for major CEUS pattern identification was evaluated.RESULTS CEUS LR-5 predicted HCC with a 67.6%sensitivity,97.7%specificity,and 99.3%PPV(P<0.001).The merging of LR-4 and 5 offered an improved 93.9%sensitivity in HCC diagnosis with a 94.3%specificity and 98.8%PPV(P<0.001).CEUS LR-M predicted ICC with a 91.3%sensitivity,96.7%specificity,and 99.6%NPV(P<0.001).CEUS LR-3 predominantly included benign lesions(only 28.8%of malignancies).In this class,the hypo-hypo pattern showed a much higher rate of malignant lesions(73.3%)than the iso-iso pattern(2.6%).Inter-rater agreement between internal raters for CEUS-LR class assignment was almost perfect(n=511,k=0.94,P<0.001),while the agreement among raters from separate centres was substantial(n=50,k=0.67,P<0.001).Agreement was stronger for arterial phase hyperenhancement(internal k=0.86,P<2.7×10-214;external k=0.8,P<0.001)than washout(internal k=0.79,P<1.6×10-202;external k=0.71,P<0.001).CONCLUSION CEUS LI-RADS is effective but can be improved by merging LR-4 and 5 to diagnose HCC and by splitting LR-3 into two subgroups to differentiate iso-iso nodules from other patterns.
摘要Prostate cancer (PCa) is one of the most common cancers among men globally. The authors aimed to evaluate the ability of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) to classify men with PCa, clinically significant PCa (CSPCa), or no PCa, especially among those with serum total prostate-specific antigen (tPSA) levels in the "gray zone" (4-10 ng ml-1). A total of 308 patients (355 lesions) were enrolled in this study. Diagnostic efficiency was determined. Univariate and multivariate analyses, receiver operating characteristic curve analysis, and decision curve analysis were performed to determine and compare the predictors of PCa and CSPCa. The results suggested that PI-RADS v2, tPSA, and prostate-specific antigen density (PSAD) were independent predictors of PCa and CSPCa. A PI-RADS v2 score L≥4 provided high negative predictive values (91.39% for PCa and 95.69% for CSPCa). A model of PI-RADS combined with PSA and PSAD helped to define a high-risk group (PI-RADS score = 5 and PSAD L≥0 15 ng ml-1 cm-3, with tPSA in the gray zone, or PI-RADS score L≥4 with high tPSA level) with a detection rate of 96.1% for PCa and 93.0% for CSPCa while a low-risk group with a detection rate of 6.1% for PCa and 2.2% for CSPCa. It was concluded that the PI-RADS v2 could be used as a reliable and independent predictor of PCa and CSPCa. The combination of PI-RADS v2 score with PSA and PSAD could be helpful in the prediction and diagnosis of PCa and CSPCa and, thus, may help in preventing unnecessary invasive procedures.
基金Supported by RSNA Research&Education Foundation Medical Student Grant#RMS2020.
摘要BACKGROUND The 2018 ovarian-adnexal reporting and data system(O-RADS)guidelines are aimed at providing a system for consistent reports and risk stratification for ovarian lesions found on ultrasound.It provides key characteristics and findings for lesions,a lexicon of descriptors to communicate findings,and risk characterization and associated follow-up recommendation guidelines.However,the ORADS guidelines have not been validated in North American institutions or amongst less experienced readers.AIM To evaluate the diagnostic accuracy and inter-reader reliability of ultrasound ORADS risk stratification amongst less experienced readers in a North American institution with and without pre-test training.METHODS A single-center retrospective study was performed using 100 ovarian/adnexal lesions of varying O-RADS scores.Of these cases,50 were allotted to a training cohort and 50 to a testing cohort via a non-randomized group selection process in order to approximately equal distribution of O-RADS categories both within and between groups.Reference standard O-RADS scores were established through consensus of three fellowship-trained body imaging radiologists.Three PGY-4 residents were independently evaluated for diagnostic accuracy and inter-reader reliability with and without pre-test O-RADS training.Sensitivity,specificity,positive predictive value,negative predictive value(NPV),and area under the curve(AUC)were used to measure accuracy.Fleiss kappa and weighted quadratic(pairwise)kappa values were used to measure inter-reader reliability.Statistical significance was P<0.05.RESULTS Mean patient age was 40±16 years with lesions ranging from 1.2 to 22.5 cm.Readers demonstrated excellent specificities(85%-100%pre-training and 91%-100%post-training)and NPVs(89%-100%pre-training and 91-100%post-training)across the O-RADS categories.Sensitivities were variable(55%-100%pre-training and 64%-100%post-training)with malignant ORADS 4 and 5 Lesions pre-training and post-training AUC values of 0.87-0.95 and 0.94-098,respectively(P<0.001).Nineteen of 22(86%)misclassified cases in pre-training were related to mischaracterization of dermoid features or wall/septation morphology.Fifteen of 17(88%)of posttraining misclassified cases were related to one of these two errors.Fleiss kappa inter-reader reliability was‘good’and pairwise inter-reader reliability was‘very good’with pre-training and post-training assessment(k=0.76 and 0.77;and k=0.77-0.87 and 0.85-0.89,respectively).CONCLUSION Less experienced readers in North America achieved excellent specificities and AUC values with very good pairwise inter-reader reliability.They may be subject to misclassification of potentially malignant lesions,and specific training around dermoid features and smooth vs irregular inner wall/septation morphology may improve sensitivity.
摘要Hepatocellular carcinoma(HCC)is the sixth most common cancer.The main risk factors associated with HCC development include hepatitis B virus,hepatitis C virus,alcohol consumption,aflatoxin B1,and nonalcoholic fatty liver disease.However,hepatocarcinogenesis is a complex multistep process.Various factors lead to hepatocyte malignant transformation and HCC development.Diagnosis and surveillance of HCC can be made with the use of liver ultrasound(US)every 6 mo.However,the sensitivity of this imaging method to detect HCC in a cirrhotic liver is limited,due to the abnormal liver parenchyma.Computed tomography(CT)and magnetic resonance imaging(MRI)are considered to be most useful tools for at-risk patients or patients with inadequate US.Liver biopsy is still used for diagnosis and prognosis of HCC in specific nodules that cannot be definitely characterized as HCC by imaging.Recently the American College of Radiology designed the Liver Imaging Reporting and Data System(LI-RADS),which is a comprehensive system for standardized interpretation of CT and MRI liver examinations that was first proposed in 2011.In 2018,it was integrated into the American Association for the Study of Liver Diseases guidance statement for HCC.LI-RADS is designed to ensure high sensitivity,precise categorization,and high positive predictive value for the diagnosis of HCC and is applied to“highrisk populations”according to specific criteria.Most importantly LI-RADS criteria achieved international collaboration and consensus among liver experts around the world on the best practices for caring for patients with or at risk for HCC.
基金Supported by Health Commission of Hubei Province,China No.WJ2019M077 and No.WJ2019H227Natural Science Foundation of Hubei Province,China No.2019CFB286and Science and Technology Bureau of Shihezi,China No.2019ZH11.
摘要BACKGROUND Hepatocellular carcinoma is the most common primary liver malignancy.From the results of previous studies,Liver Imaging Reporting and Data System(LIRADS)on contrast-enhanced ultrasound(CEUS)has shown satisfactory diagnostic value.However,a unified conclusion on the interobserver stability of this innovative ultrasound imaging has not been determined.The present metaanalysis examined the interobserver agreement of CEUS LI-RADS to provide some reference for subsequent related research.AIM To evaluate the interobserver agreement of LI-RADS on CEUS and analyze the sources of heterogeneity between studies.METHODS Relevant papers on the subject of interobserver agreement on CEUS LI-RADS published before March 1,2020 in China and other countries were analyzed.The studies were filtered,and the diagnostic criteria were evaluated.The selected references were analyzed using the“meta”and“metafor”packages of R software version 3.6.2.RESULTS Eight studies were ultimately included in the present analysis.Meta-analysis results revealed that the summary Kappa value of included studies was 0.76[95%confidence interval,0.67-0.83],which shows substantial agreement.Higgins I2 statistics also confirmed the substantial heterogeneity(I2=91.30%,95%confidence interval,85.3%-94.9%,P<0.01).Meta-regression identified the variables,including the method of patient enrollment,method of consistency testing,and patient race,which explained the substantial study heterogeneity.CONCLUSION CEUS LI-RADS demonstrated overall substantial interobserver agreement,but heterogeneous results between studies were also obvious.Further clinical investigations should consider a modified recommendation about the experimental design.
摘要Hepatocellular carcinoma(HCC)is a leading cause of morbidity and mortality worldwide,with rising clinical and economic burden as incidence increases.There are a multitude of evolving treatment options,including locoregional therapies which can be used alone,in combination with each other,or in combination with systemic therapy.These treatment options have shown to be effective in achieving remission,controlling tumor progression,improving disease free and overall survival in patients who cannot undergo resection and providing a bridge to transplant by debulking tumor burden to downstage patients.Following locoregional therapy(LRT),it is crucial to provide treatment response assessment to guide management and liver transplant candidacy.Therefore,Liver Imaging Reporting and Data Systems(LI-RADS)Treatment Response Algorithm(TRA)was created to provide a standardized assessment of HCC following LRT.LIRADS TRA provides a step by step approach to evaluate each lesion independently for accurate tumor assessment.In this review,we provide an overview of different locoregional therapies for HCC,describe the expected post treatment imaging appearance following treatment,and review the LI-RADS TRA with guidance for its application in clinical practice.Unique to other publications,we will also review emerging literature supporting the use of LI-RADS for assessment of HCC treatment response after LRT.
摘要Objective:Vesical Imaging Reporting and Data System(VIRADS)score was developed to standardize the reporting and staging of bladder tumors on pre-operative multiparametric magnetic resonance imaging.It helps in avoiding unnecessary repeat transurethral resection of bladder tumor in high-risk non-muscle-invasive bladder cancer patients.This study was done to determine the validity of VIRADS score prospectively for the diagnosis of muscleinvasive bladder cancer.Methods:This study was conducted from March 2019 to March 2020 at Sawai Man Singh Medical College and Hospital,Jaipur,Rajasthan,India.Patients admitted with the provisional diagnosis of bladder tumor were included as participants.All these patients underwent a 3 Tesla mpMRI to obtain a VIRADS score before they underwent transurethral resection of bladder tumor and these data were analyzed to evaluate the correlation of pre-operative VIRADS score with mus-cle invasiveness of the tumor in final biopsy report.Results:A cut-off of VIRADS≥4 for prediction of detrusor muscle invasion yielded a sensitivity of 79.4%,specificity of 94.2%,positive predictive value of 90.0%,negative predictive value of 87.5%,and diagnostic accuracy of 86.4%.A cut off of VIRADS≥3 for prediction of detrusor muscle invasion yielded a sensitivity of 91.2%,specificity of 78.8%,positive predictive value of 73.8%,negative predictive value of 93.2%,and accuracy of 83.7%.The receiver operating curve showed the area under the curve to be 0.922(95%confidence interval:0.862e0.983).Conclusion:VIRADS score appears to be an excellent and effective pre-operative radiological tool for the prediction of detrusor muscle invasion in bladder cancer.
摘要BACKGROUND The American College of Radiology Thyroid Imaging Reporting and Data System(ACR TI-RADS)was introduced to standardize the ultrasound characterization of thyroid nodules.Studies have shown that ACR-TIRADS reduces unnecessary biopsies and improves consistency of imaging recommendations.Despite its widespread adoption,there are few studies to date assessing the inter-reader agreement amongst radiology trainees with limited ultrasound experience.We hypothesize that in PGY-4 radiology residents with no prior exposure to ACR TIRADS,a statistically significant improvement in inter-reader reliability can be achieved with a one hour training session.AIM To evaluate the inter-reader agreement of radiology residents in using ACR TIRADS before and after training.METHODS A single center retrospective cohort study evaluating 50 thyroid nodules in 40 patients of varying TI-RADS levels was performed.Reference standard TI-RADS scores were established through a consensus panel of three fellowship-trained staff radiologists with between 1 and 14 years of clinical experience each.Three PGY-4 radiology residents(trainees)were selected as blinded readers for this study.Each trainee had between 4 to 5 mo of designated ultrasound training.No trainee had received specialized TI-RADS training prior to this study.Each of the readers independently reviewed the 50 testing cases and assigned a TI-RADS score to each case before and after TI-RADS training performed 6 wk apart.Fleiss kappa was used to measure the pooled inter-reader agreement.The relative diagnostic performance of readers,pre-and post-training,when compared against the reference standard.RESULTS There were 33 females and 7 males with a mean age of 56.6±13.6 years.The mean nodule size was 19±14 mm(range from 5 to 63 mm).A statistically significant superior inter-reader agreement was found on the post-training assessment compared to the pre-training assessment for the following variables:1.“Shape”(k of 0.09[slight]pre-training vs 0.67[substantial]post-training,P<0.001),2.“Echogenic foci”(k of 0.28[fair]pre-training vs 0.45[moderate]post-training,P=0.004),3.‘TI-RADS level’(k of 0.14[slight]pre-training vs 0.36[fair]post-training,P<0.001)and 4.‘Recommendations’(k of 0.36[fair]pre-training vs 0.50[moderate]post-training,P=0.02).No significant differences between the preand post-training assessments were found for the variables'composition','echogenicity'and'margins'.There was a general trend towards improved pooled sensitivity with TI-RADS levels 1 to 4 for the post-training assessment while the pooled specificity was relatively high(76.6%-96.8%)for all TI-RADS level.CONCLUSION Statistically significant improvement in inter-reader agreement in the assigning TI-RADS level and recommendations after training is observed.Our study supports the use of dedicated ACR TI-RADS training in radiology residents.
基金Supported by Hunan Provincial Natural Science Foundation Regional Joint Fund,No.2023JJ50050.
摘要BACKGROUND Collision tumor are neoplasms,including two histologically distinct tumors that coexist in the same mass without histological admixture.The incidence of collision tumor is low and is rare clinically.AIM To investigate ultrasound images and application of ovarian-adnexal reporting and data system(O-RADS)to evaluate the risk and pathological characteristics of ovarian collision tumor.METHODS This study retrospectively analyzed 17 cases of ovarian collision tumor diagnosed pathologically from January 2020 to December 2023.All clinical features,ultrasound images and histopathological features were collected and analyzed.The O-RADS score was used for classification.The O-RADS score was determined by two senior doctors in the gynecological ultrasound group.Lesions with O-RADS score of 1-3 were classified as benign tumors,and lesions with O-RADS score of 4 or 5 were classified as malignant tumors.RESULTS There were 17 collision tumors detected in 16 of 6274 patients who underwent gynecological surgery.The average age of 17 women with ovarian collision tumor was 36.7 years(range 20-68 years),in whom,one occurred bilaterally and the rest occurred unilaterally.The average tumor diameter was 10 cm,of which three were 2-5 cm,11 were 5-10 cm,and three were>10 cm.Five(29.4%)tumors with O-RADS score 3 were endometriotic cysts with fibroma/serous cystadenoma,and unilocular or multilocular cysts contained a small number of parenchymal components.Eleven(64.7%)tumors had an O-RADS score of 4,including two in category 4A,six in category 4B,and three in category 4C;all of which were multilocular cystic tumors with solid components or multiple papillary components.One(5.9%)tumor had an O-RADS score of 5.This case was a solid mass,and a small amount of pelvic effusion was detected under ultrasound.The pathology was high-grade serous cystic cancer combined with cystic mature teratoma.There were nine(52.9%)tumors with elevated serum carbohydrate antigen(CA)125 and two(11.8%)with elevated serum CA19-9.Histological and pathological results showed that epithelial-cell-derived tumors combined with other tumors were the most common,which was different from previous results.CONCLUSION The ultrasound images of ovarian collision tumor have certain specificity,but diagnosis by preoperative ultrasound is difficult.The combination of epithelial and mesenchymal cell tumors is one of the most common types of ovarian collision tumor.The O-RADS score of ovarian collision tumor is mostly≥4,which can sensitively detect malignant tumors.
基金supported by the National Natural Science Foundation(No. 40905046,No.41175066)the National High Technology Research and Development Program(No.2009AA1220005, No.2009BAC51B03)the National Basic Research Program (No.2010CB951902)of China
摘要A series of quality control(QC) procedures were performed on a gauge-based global daily precipitation dataset from the Global Telecommunication System(GTS) for the period 1980-2009.A new global daily precipitation(NGDP) dataset was constructed by applying those QC procedures to eliminate erroneous records.The NGDP dataset was evaluated using the NOAA Climate Prediction Center Merged Analysis of Precipitation(CMAP) and the Global Precipitation Climatology Project(GPCP) precipitation datasets.The results showed that the frequency distribution and spatial distribution pattern of NGDP had a nice match with those from the CMAP and GPCP datasets.The global mean correlation coefficients with the CMAP and GPCP data increased from 0.24 for original GTS precipitation data to about 0.70 for NGDP data.Correspondingly,the root mean square errors(RMSE) decreased from 12 mm per day to 1 mm per day.The interannual variabilities of NGDP monthly precipitation are consistent with the CMAP and GPCP datasets in Asia.Meanwhile,the seasonal variabilities for most land areas on the Earth of NGDP dataset are also consistent with the CMAP and GPCP precipitation products.
基金partly supported by a grant from the Johns Hopkins Center for Global Health(SM,QL)the Global Road Safety Program of Bloomberg Philanthropies grant to the Johns Hopkins International Injury Research Unit (SM,QL)the 2009 New Century Scholar Support of Ministry of Education of China (NCET-10-0782)(GH)
摘要Pedestrian safety in China is an important but largely neglected issue, in part due to the substantial under-reporting within police data. In this study we aimed to examine changes in pedestrian fatality between 2006 and 2010 in China using non-police reported data. A multi-year study was conducted based on the mortality data during 2006-2010 from the Disease Surveillance Points (DSP) data in China. Between 2006 and 2010, the crude pedestrian mortality increased from 7.0 to 10.5 per 100 000 populations. Annual pedestrian mortality from DSP data was 13 times in 2006 and 55 times in 2010 mortality for pedestrians and passengers from police-reported data in the corresponding years. After controlling for sex, age,
基金Supported by Natural Science Foundation of Sichuan Province,China,No.2024NSFSC0657Sichuan Medical Association Tumor(Hengrui-a Line)Special Scientific Research Project,China,No.2024HR123Innovation Team Foundation of the Affiliated Hospital of Chengdu University,China,No.CDFYCX202204.
摘要BACKGROUND Prostate cancer(PCa)is the second most common malignancy and the fifth leading cause of cancer death among men worldwide.Magnetic resonance imaging(MRI)-based radiomics has emerged as a promising tool for diagnosing PCa,but its true potential remains a subject of ongoing debate.AIM To evaluate the diagnostic performance of MRI-based radiomics for PCa detection and compare it with the Prostate Imaging Reporting and Data System(PI-RADS)score.METHODS A systematic search of EMBASE,Web of Science,and PubMed was conducted up to August 18,2025.Pooled sensitivity,specificity,and area under the curve were calculated.Subgroup analyses were performed to evaluate heterogeneity.Additionally,the diagnostic accuracy of MRI-based radiomics was compared with that of the PI-RADS score.Methodological quality was evaluated via the Radiomics Quality Score.RESULTS This meta-analysis included 49 studies encompassing 10512 patients.MRI-based radiomics demonstrated a pooled sensitivity of 0.84[95%confidence interval(CI):0.80-0.87],specificity of 0.78(95%CI:0.72-0.84),and area under the curve of 0.88(95%CI:0.85-0.91).Deek’s funnel plot asymmetry test indicated no publication bias.Subgroup analyses revealed that multiparametric MRI-based radiomics is more effective in diagnosing clinically significant PCa and that 3D-based radiomics outperforms 2D approaches.In a head-to-head comparison,the MRI-radiomics model yielded a numerically greater pooled diagnostic value(0.85;95%CI:0.82-0.88)than did the PI-RADS score(0.71;95%CI:0.63-0.77)(P=0.07).The mean Radiomics Quality Score was 18.2(50.6%of the maximum score).All studies reported performing cut-off analyses,22 studies(44.9%)addressed biological correlates,and all claimed code or data accessibility.CONCLUSION MRI-based radiomics is a reliable tool for detecting PCa,with 3D radiomic models showing greater effectiveness than 2D approaches in terms of sensitivity(0.85 vs 0.79).Radiomics also offers superior diagnostic accuracy for clinically significant PCa compared with the PI-RADS score,underscoring its potential in improving PCa diagnostics.
基金funding from the Australian Research Council LIEF programme(LE150100013).
摘要Lead (Pb) isotopes can provide key information to address fundamental geologic problems related to the formation and evolution of rocky planets. The Pb isotope system supports a diversity of applications, as it provides access to information on magma sources as well as geologic age. Consequently, a wide range of analytical techniques, data validation and interpretation strategies have been advanced across a range of Pb isotope studies. Given the multiple different Pb isotope pairs, reflecting different decay rates and ultimate parental isotope concentrations, Pb isotopes have been viewed as one of the more challenging isotope systems to comprehend. Here we provide an overview of the various analytical and interpretative approaches, for this system, and highlight their respective strengths in the context of applications, such as magma source tracking and model age determination. A discussion of different methods to determine magma source parameters (e.g., U/Pb ratio and model age) is presented, along with recommendations for data validation and reporting. A checklist for recommended data and metadata to report for Pb isotopes is provided. The aim of this contribution is to provide a framework that enables a robust interpretation of Pb isotope signatures, promoting data transparency and comparison across different analytical approaches.
摘要Purpose: The objective of the study was to design and implement an electronic synoptic report for thyroid sonography that incorporates the thyroid imaging reporting and data system (TIRADS) and assess potential for reducing unnecessary fine needle aspiration biopsies (FNAB) of thyroid nodules. Methods: The electronic synoptic report was developed using a relational database based on elements from TIRADS and a multidisciplinary consensus statement for thyroid reporting. A retrospective analysis of 138 patients with previously reported thyroid sonographic exams was evaluated for the presence of these elements. The electronic synoptic report calculates the TIRADS score and generates a formal report. Using the TIRADS score the potential decrease in unnecessary FNAB was estimated. Results: Key TIRADS elements were variously reported ranging from 43% for the thyroid nodule’s architecture as solid or cystic. Thyroid nodule echogenicity and calcification was commented in 27% and 23%, respectively. Other features of the TIRADS score were commented in 0% to 8% of the official reports. Estimated reduction for potentially reduced need for FNAB was 34.5%. Conclusions: This study is the first implementation of synoptic reporting using a relational database for sonography of thyroid nodules. Implementation of an electronic standardized synoptic reporting system may facilitate more accurate, and more comprehensive reporting for thyroid ultrasound scanning of thyroid nodules. The use of TIRADS was estimated to be able to potentially reduce the need for FNAB which was significant.
基金This study was approved by the Medical Ethics Committee of Jieshou City People's Hospital,approval No.[2022]21.
摘要BACKGROUND Currently,only tumors classified as LR-5 are considered definitive hepatocellular carcinoma(HCC),and no further pathologic confirmation is required to initiate therapy.Previous studies have shown that the sensitivity of LR-5 is modest,and lesions enhanced by gadoxetic acid(Gd-EOB-DTPA)may exhibit lower sensitivity than those enhanced by Gd-DTPA.AIM To identify malignant ancillary features(AFs)that can independently and significantly predict HCC in Liver Imaging Reporting and Data System version 2018,and to develop modified LR-5 criteria to improve diagnostic performance on Gd-EOB-DTPA-enhanced magnetic resonance imaging.METHODS Imaging data from patients with HCC risk factors who underwent abdominal Gd-EOB-DTPA-enhanced magnetic resonance imaging were collected.Univariate and multivariate logistic regression analyses were performed to determine AFs that could independently and significantly predict HCC.The modified LR-5 criteria involved reclassifying LR-4/LR-3 lesions based on major features combined with independently significant AFs for HCC,or by substituting threshold growth with significant AFs.McNemar's test was used to compare the diagnostic performance of the modified LR-5 criteria.RESULTS A total of 244 lesions from 216 patients were included.Transitional phase hypointensity,mild-moderate T2 hyperintensity,and fat in mass(more than adjacent liver)were identified as significant independent predictors of HCC.Using the modified LR-5 criteria(e.g.,LR-5-M1:LR-4+transitional phase hypointensity;LR-5-M4:LR-5 by transitional phase hypointensity instead of threshold growth;LR-5-M5:LR-5 by mild-moderate T2 hyperintensity instead of threshold growth;LR-5-M8:LR-3/LR-4+any two features of transitional phase hypointensity/mild-moderate T2 hyperintensity/fat in mass),sensitivities were significantly increased(88.5%-89.1%)compared to the standard LR-5(60.6%;all P values0.05).The LR-5-M8 criterion achieved the highest sensitivity.CONCLUSION Mild-moderate T2 hyperintensity,transitional phase hypointensity,and fat in mass are independent and significant predictors of HCC malignant AFs.The modified LR-5 criteria can improve sensitivity without significantly reducing specificity.