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Role of diffusion-weighted magnetic resonance imaging and apparent diffusion coefficient in subtyping renal cell carcinoma 认领 引用
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作者 Hira Lal Pinky Jowel +9 位作者 Pragati Verma Athar Shamim Raghunandan Prasad Anuradha Singh Uday P Singh Sanjoy K Sureka Farhana Siddiqui Manoj Jain Aneesh Srivastava Priyank Yadav 《World Journal of Radiology》 2026年第5期67-76,共10页
BACKGROUND Diffusion-weighted magnetic resonance imaging(DWI)has emerged as a noncontrast functional imaging technique for renal mass characterization.Its role in differentiating histopathological subtypes of renal ce... BACKGROUND Diffusion-weighted magnetic resonance imaging(DWI)has emerged as a noncontrast functional imaging technique for renal mass characterization.Its role in differentiating histopathological subtypes of renal cell carcinoma(RCC)remains an area of active investigation.AIM To evaluate the role of DWI and apparent diffusion coefficient(ADC)values in differentiating histopathological subtypes of RCC.METHODS In this prospective observational study,127 patients with histopathologically proven RCC who underwent preoperative magnetic resonance imaging(MRI)including DWI were analyzed.Diffusion-weighted imaging was performed using b values of 0 second/mm2 and 1000 seconds/mm2,and ADC maps were generated.ADC values were measured from solid tumor components and compared among RCC subtypes.Statistical analysis included subgroup comparisons and receiver operating characteristic curve analysis to assess the ability of ADC values to differentiate clear cell RCC(ccRCC)from non-ccRCC.RESULTS Of the 127 RCCs,97(76.4%)were ccRCC,24(18.9%)papillary RCC,and 6(4.7%)chromophobe RCC.The mean ADC value of ccRCC[(1.391±0.271)×10-3mm2/second]was significantly higher than that of papillary RCC[(0.876±0.293)×10-3mm2/second;P<0.001]and chromophobe RCC[(1.059±0.369)×10-3mm2/second;P=0.04].No significant difference was observed between papillary and chromophobe RCC(P=0.396).When grouped,ccRCC demonstrated a significantly higher mean ADC value compared with non-ccRCC[(1.391±0.271)×10-3mm2/second vs(0.915±0.312)×10-3mm2/second;P<0.001].Receiver operating characteristic analysis yielded an area under the curve of 0.889(95%confidence interval:0.804-0.975).An ADC threshold of 1.08×10-3mm2/second achieved 90%sensitivity and 83%specificity for identifying ccRCC.CONCLUSION DWI with quantitative ADC analysis reliably differentiates clear cell from non-ccRCC and demonstrates significant correlation with RCC subtype and tumor grade.DWI serves as a valuable adjunct to conventional MRI,particularly in patients with contraindications to contrast administration. 展开更多
关键词 Renal cell carcinoma Diffusion-weighted imaging Apparent diffusion coefficient Magnetic resonance imaging Tumor subtyping
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Comparative Study on the Efficiency of Magnetic Resonance Diffusion-Weighted Imaging in Differentiating Benign and Malignant Intracranial Mass Lesions 认领 引用
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作者 HAN Xiaojing SUN Di 《外文科技期刊数据库（文摘版）医药卫生》 2026年第5期149-153,共5页
Objective: To investigate the efficacy and accuracy of quantitative parameters and visual features in magnetic resonance diffusion-weighted imaging (MRI DWI) for distinguishing between benign and malignant intracrania... Objective: To investigate the efficacy and accuracy of quantitative parameters and visual features in magnetic resonance diffusion-weighted imaging (MRI DWI) for distinguishing between benign and malignant intracranial space-occupying lesions. Methods: A total of 100 patients with intracranial space-occupying lesions were enrolled in this study from January 2024 to January 2026. All participants underwent standardized head MRI scans including DWI sequences prior to surgery. During the study, regions of interest were delineated within the solid areas of lesions to obtain their mean apparent diffusion coefficient (ADC) values. Additionally, two experienced radiologists independently assessed the diffusion signal characteristics and contour features of the lesions, with the final pathological diagnosis serving as the gold standard. Differences in various observation parameters between benign and malignant lesions were compared. Results: The group of lesions diagnosed as malignant (n=52) exhibited a mean ADC value of (0.72±0.15)×10⁻³ mm²/s, whereas the benign group (n=48) showed a mean value of (1.21±0.28)×10⁻³ mm²/s;the difference was statistically significant (P<0.01). Imaging feature analysis revealed that malignant lesions more frequently demonstrated significant diffusion restriction and ill-defined infiltrative growth patterns. When setting the ADC diagnostic threshold at 0.89×10⁻³ mm²/s, the sensitivity and specificity for differentiating benign from malignant lesions were evaluated. The values reached 90.4% and 83.3%, respectively, with a area under the receiver operating characteristic curve equal to 0.92. Conclusion: The combined application of quantitative ADC measurement via magnetic resonance diffusion-weighted imaging (MRI DWI) and morphological feature analysis particularly provides a relatively objective and efficient imaging reference for non-invasively assessing the nature of intracranial space-occupying lesions prior to surgery. 展开更多
关键词 Magnetic resonance imaging Diffusion-weighted imaging Apparent diffusion coefficient Intracranial space-occupying lesions Differentiation between benign and malignant lesions
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Diffusion-weighted magnetic resonance imaging of the pancreas:A narrative review 认领 引用 被引量：2
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作者 Qing-Yu Gao Li-Jia Wang Chao Ma 《World Journal of Radiology》 2025年第10期14-25,共12页
Diffusion-weighted magnetic resonance imaging(DWI)has become an essential tool in the field of pancreatic magnetic resonance imaging,enabling the detection,characterization,prediction,and evaluation of pancreatic dise... Diffusion-weighted magnetic resonance imaging(DWI)has become an essential tool in the field of pancreatic magnetic resonance imaging,enabling the detection,characterization,prediction,and evaluation of pancreatic diseases.In this article,we review the acquisition parameters,postprocessing techniques,and quantitative methods utilized in pancreatic DWI.Various postprocessing models,including monoexponential,biexponential,stretched exponential and non-Gaussian kurtosis models,as well as deep learning networks,have been used to assess the clinical utility of these models in diagnosing pancreatic diseases.The single-shot echo-planar imaging sequence is the most commonly used sequence for DWI data acquisition in clinical settings,and the apparent diffusion coefficient(ADC)calculated using the monoexponential model is the most widely used quantitative parameter in clinical practice.The repeatability threshold for the ADC of a normal pancreas is 37%for test-retest scans,but the repeatability threshold for pancreatic tumors needs to be further investigated.Complex postprocessing models exploring novel DWI-based biomarkers beyond ADC to assess histological features,and artificial intelligence in DWI postprocessing and data analyses hold promise in the diagnosis of pancreatic diseases.Future work should focus on standardizing protocols,conducting multicentre studies,and exploring variety of methods to improve the accuracy of quantitative DWI results to increase the clinical effectiveness of DWI in patients with pancreatic diseases. 展开更多
关键词 Diffusion-weighted imaging Pancreas Magnetic resonance imaging Model Artificial intelligence
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The applied research of simultaneous image acquisition of T2-weighted imaging(T2WI)and diffusion-weighted imaging(DWI)in the assessment of patients with prostate cancer 认领 引用 被引量：8
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作者 Yi Liu Wei Wang +4 位作者 Xiu-Bo Qin Hui-Hui Wang Ge Gao Xiao-Dong Zhang Xiao-Ying Wang 《Asian Journal of Andrology》 SCIE CAS CSCD 2019年第2期177-182,共6页
We aimed to evaluate the feasibility of simultaneous image acquisition of multiple instantaneous switchable scan(MISS)for prostate magnetic resonance imaging(MRI)on 3T.Fifty-three patients were scanned with MRI due to... We aimed to evaluate the feasibility of simultaneous image acquisition of multiple instantaneous switchable scan(MISS)for prostate magnetic resonance imaging(MRI)on 3T.Fifty-three patients were scanned with MRI due to suspected prostate cancer.Twenty-eight of them got histological results.First,two readers assessed the structure delineation and image quality based on images of conventional T2-weighted imaging(T2WI)and diffusion-weighted imaging(DWI)(CTD).Second,two readers identified the index lesion together,and then,reader one evaluated the contrast of index lesion on T2WI and signal ratio on apparent diffusion coefficient map.Third,they assigned Prostate Imaging Reporting and Data System(PI-RADS)score in consensus for the index lesion.After 4 weeks,the images of MISS were reviewed by the same readers following the same process.Finally,two readers gave preference for image interpretation,respectively.Kappa coefficient,Wilcoxon signed-rank test,paired-sample t-test,Bland-Altman analysis,and receiver operating characteristic(ROC)analysis were used for statistical analysis.The acquisition time of CTD was 6 min and 10 st while the acquisition time of MISS was 4 min and 30 s.Interobserver agreements for image evaluation were k=0.65 and k=0.80 for CTD and MISS,respectively.MISS-T2WI showed better delineation for seminal vesicles than CTD-T2WI(reader 1:P<0.001,reader 2:P=0.001).The index lesion demonstrated higher contrast in MISS-T2WI(P<0.001).The FI-RADS scores based on CTD and MISS exhibited high ability in predicting clinically significant cancer(area under curve[AUC]=0.828 vs 0.854).Readers preferred to use MISS in 41.5%-47.2%of cases.MISS showed comparable performance to conventional technique with less acquisition time. 展开更多
关键词 diffusion-weighted imaging magnetic resonance imaging prostate cancer
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T2 magnetic resonance imaging combined with diffusion-weighted imaging for colon cancer lymph nodes 认领 引用
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作者 Yong-Xia Li Sheng-Li Cai +3 位作者 Ming-Yang Peng Tong-Xing Wang Wen Geng Yue-Hu Ma 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第6期100-106,共7页
BACKGROUND Colorectal cancer is a malignancy with a high risk of lymph node metastasis and poor prognosis,and thus requires an accurate diagnosis.AIM To assess the diagnostic value of combined magnetic resonance T2-we... BACKGROUND Colorectal cancer is a malignancy with a high risk of lymph node metastasis and poor prognosis,and thus requires an accurate diagnosis.AIM To assess the diagnostic value of combined magnetic resonance T2-weighted imaging(T2WI)and diffusion-weighted imaging(DWI)in colorectal cancer.METHODS We included 120 patients with suspected colorectal cancer who underwent magnetic resonance imaging.Surgical pathology was used as the gold standard for comparison.Combined T2WI and DWI showed higher diagnostic efficacy than either of the two methods used individually.RESULTS The combined method achieved 94.74%sensitivity,95.45%specificity,95.00%accuracy,94.74%positive predictive value,and 95.45%negative predictive value in qualitative diagnosis.It showed 94.44%sensitivity,95.00%specificity,94.74%accuracy,94.44%positive predictive value,and 95.00%negative predictive value in clinical staging.Finally,it showed 94.74%sensitivity,94.59%specificity,94.74%accuracy,94.74%positive predictive value,and 94.59%negative predictive value in diagnosing lymph node metastasis.These results were highly consistent with that of the gold standard.CONCLUSION This study combined T2WI and DWI for accurate diagnosis of colorectal cancer,aiding clinical staging and lymph node metastasis assessment.This approach is promising for clinical application. 展开更多
关键词 Magnetic resonance T2-weighted imaging Diffusion-weighted imaging Colorectal cancer Lymph node metastasis Diagnostic efficacy
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Multimodal MRI Enhancement Combined with Diffusion-Weighted Imaging for the Differential Diagnosis of Non-Lactating Mastitis and Breast Cancer 认领 引用
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作者 Yongxiang Wei 《Journal of Clinical and Nursing Research》 2025年第6期154-160,共7页
Objective:To explore the value of multimodal MRI enhancement scanning and diffusion-weighted imaging in differentiating non-puerperal mastitis(NPM)and breast cancer.Methods:From September 2022 to September 2024,56 pat... Objective:To explore the value of multimodal MRI enhancement scanning and diffusion-weighted imaging in differentiating non-puerperal mastitis(NPM)and breast cancer.Methods:From September 2022 to September 2024,56 patients with breast diseases were selected as samples and grouped according to disease type.Twenty-eight patients with breast cancer were included in Group A,and 28 patients with NPM were included in Group B.All patients underwent multimodal MRI enhancement scanning and diffusion-weighted imaging.The MRI results,time-signal intensity curves,ADC values,lesion intensity,and imaging signs were compared between the two groups.Results:There were no significant differences in enhancement characteristics,lymph node enlargement,and margins between Group A and Group B(P>0.05).The proportion of outflow curves in Group A was higher than that in Group B(P<0.05).The ADC value in Group A was lower than that in Group B,and the lesion intensity was higher than that in Group B(P<0.05).There were significant differences in imaging signs,such as abscess or sinus,ascending time-signal curve,and mammary duct dilation between Group A and Group B(P<0.05).Conclusion:Multimodal MRI enhancement scanning and diffusion-weighted imaging techniques can be used to diagnose breast diseases.Comprehensive analysis of time-signal intensity curves,lesion intensity,imaging signs,and ADC values can differentiate between NPM and breast cancer. 展开更多
关键词 Breast cancer NPM MRI Enhanced imaging Diffusion-weighted imaging
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Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions 认领 引用 被引量：39
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作者 Naoto Koike Akihiro Cho +4 位作者 Katsuhiro Nasu Kazuhiko Seto Shigeyuki Nagaya Yuji Ohshima Nobuhiro Ohkohchi 《World Journal of Gastroenterology》 SCIE CAS 2009年第46期5805-5812,共8页
AIM： To evaluate the utility of diffusion-weighted imaging （DWl） in screening and differential diagnosis of benign and malignant focal hepatic lesions. METHODS： Magnetic resonance imaging （MRI） examinations were... AIM： To evaluate the utility of diffusion-weighted imaging （DWl） in screening and differential diagnosis of benign and malignant focal hepatic lesions. METHODS： Magnetic resonance imaging （MRI） examinations were performed using the Signa Excite Xl Twin Speed 1.5T system （GE Healthcare, Milwaukee, Wl, USA）. Seventy patients who had undergone MRI of the liver [29 hepatocellular carcinomas （HCC）, four cholangiocarcinomas, 34 metastatic liver cancers, 10 hemangiomas, and eight cysts] between April 2004 and August 2008 were retrospectively evaluated. Visualization of lesions, relative contrast ratio （RCR）, and apparent diffusion coefficient （ADC） were compared between benign and malignant lesions on DWl. Su- perparamagnetic iron oxide （SPIO） was administered to 59 patients, and RCR was compared pre- and postadministration.RESULTS： DWI showed higher contrast between malignant lesions （especially in multiple small metastatic cancers） and surrounding liver parenchyma than did contrast-enhanced computed tomography. ADCs （mean±SD × 10^-3 mm2/s） were significantly lower （P 〈 0.05） in malignant lesions （HCC： 1.31 ± 0.28 and liver metastasis： 1.11 ± 0.22） and were significantly higher in benign lesions （hemangioma： 1.84 ± 0.37 and cyst： 2.61 ± 0.45） than in the surrounding hepatic tissues. RCR between malignant lesions and surrounding he- patic tissues significantly improved after SPIO administration, but RCRs in benign lesions were not improved.CONCLUSION： DWI is a simple and sensitive method for screening focal hepatic lesions and is useful for differential diagnosis. 展开更多
关键词 Hepatic tumor Liver imaging Magneticresonance imaging Diffusion-weighted imaging Apparent diffusion coefficient
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Diffusion-weighted images(DWI) without ADC values in assessment of small focal nodules in cirrhotic liver 认领 引用 被引量：19
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作者 Mai-Lin Chen Xiao-Yan Zhang +3 位作者 Li-Ping Qi Qing-Lei Shi Bin Chen Ying-Shi Sun 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2014年第1期38-47,共10页
Objective： To assess if diffusion-weighted magnetic resonance （MR） imaging without apparent diffusion coefficient （ADC） values provides added diagnostic value in combination with conventional MR imaging in the de... Objective： To assess if diffusion-weighted magnetic resonance （MR） imaging without apparent diffusion coefficient （ADC） values provides added diagnostic value in combination with conventional MR imaging in the detection and characterization of small nodules in cirrhotic liver. Methods： Two observers retrospectively and independently analyzed 86 nodules （_〈3 em） certified pathologically in 33 patients with liver cirrhosis, including 48 hepatocellular carcinoma （HCC） nodules, 13 high-grade dysplastic nodules （HDN）, 10 low-grade dysplastic nodules （LDNs） and 15 other benign nodules. All these focal nodules were evaluated with conventional MR images （Tl-weighted, T2-weighted and dynamic gadolinium-enhanced images） and breath-hold diffusion-weighted images （DWI） （b=500 s/mm2）. The nodules were classified by using a scale of 1-3 （1, not seen; 3, well seen） on DWI for qualitative assessment. These small nodules were characterized by two radiologists. ADC values weren＇t measured. The diagnostic performance of the combined DWI-conventional images and the conventional images alone was evaluated using receiver operating characteristic （ROC） curves. The area under the curves （Az）, sensitivity and specificity values for characterizing different small nodules were also calculated. Results： Among 48 HCC nodules, 33 （68.8%） were graded as 3 （well seen）, 6 （12.5%） were graded as 2 （partially obscured）, and 9 weren＇t seen on DWI. Among 13 HDNs, there were 3 （23.1%） and 4 （30.8%） graded as 3 and 2 respectively. Five （50%） of 10 benign nodules were partially obscured and slightly hyperintense. For 86 nodules, the average diagnostic accuracy of combined DWI-conventional images was 82.56%, which was increased significantly compared with conventional MR images with 76.17%. For HCC and HDN, the diagnostic accuracy of combined DWI-conventional images increased from 78.69% to 86.07 %. Conclusions： Diffusion-weighted MR imaging does provide added diagnostic value in the detection and characterization of HDN and HCC, and it may not be helpful for LDN and regenerative nodule （RN） in cirrhotic liver. 展开更多
关键词 Diffusion-weighted imaging magnetic resonance （MR） imaging cirrhosis nodule
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Diffusion-weighted imaging of biliopancreatic disorders:Correlation with conventional magnetic resonance imaging 认领 引用 被引量：10
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作者 Nam Kyung Lee Suk Kim +5 位作者 Gwang Ha Kim Dong Uk Kim Hyung Il Seo Tae Un Kim Dae Hwan Kang Ho Jin Jang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第31期4102-4117,共16页
Diffusion-weighted magnetic resonance imaging(DWI)is a well established method for the evaluation of intracranial diseases,such as acute stroke.DWI for extracranial application is more difficult due to physiological m... Diffusion-weighted magnetic resonance imaging(DWI)is a well established method for the evaluation of intracranial diseases,such as acute stroke.DWI for extracranial application is more difficult due to physiological motion artifacts and the heterogeneous composition of the organs.However,thanks to the newer technical development of DWI,DWI has become increasingly used over the past few years in extracranial organs including the abdomen and pelvis.Most previous studies of DWI have been limited to the evaluation of diffuse parenchymal abnormalities and focal lesions in abdominal organs,whereas there are few studies about DWI for the evaluation of the biliopancreatic tract.Although further studies are needed to determine its performance in evaluating bile duct,gallbladder and pancreas diseases,DWI has potential in the assessment of the functional information on the biliopancreatic tract concerning the status of tissue cellularity,because increased cellularity is associated with impeded diffusion,as indicated by a reduction in the apparent diffusion coefficient.The detection of malignant lesions and their differentiation from benign tumor-like lesions in the biliopancreatic tract could be improved using DWI in conjunction with findings obtained with conventional magnetic resonance cholagiopancreatography.Additionally,DWI can be useful for the assessment of the biliopancreatic tract in patients with renal impairment because contrast-enhanced computed tomography or magnetic resonance scans should be avoided in these patients. 展开更多
关键词 Magnetic resonance imaging Diffusion-weighted imaging Biliary tract Gallbladder Pancreas
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Characteristics and pathological mechanism on magnetic resonance diffusion-weighted imaging after chemoembolization in rabbit liver VX-2 tumor model 认领 引用 被引量：16
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作者 You-Hong Yuan En-Hua Xiao +6 位作者 Jian-Bin Liu Zhong He Ke Jin Cong Ma Jun Xiang Jian-Hua Xiao Wei-Jian Chen 《World Journal of Gastroenterology》 SCIE CAS 2007年第43期5699-5706,共8页
AIM: To investigate dynamic characteristics and pathological mechanism of signal in rabbit VX-2 tumor model on diffusion-weighted imaging (DWI) after chemoembolization. METHODS: Forty New Zealand rabbits were included... AIM: To investigate dynamic characteristics and pathological mechanism of signal in rabbit VX-2 tumor model on diffusion-weighted imaging (DWI) after chemoembolization. METHODS: Forty New Zealand rabbits were included in the study and forty-seven rabbit VX-2 tumor models were raised by implanting directly and intrahepatically after abdominal cavity opened. Forty VX-2 tumor models from them were divided into four groups. DWI was performed periodically and respectively for each group after chemoembolization. All VX-2 tumor samples of each group were studied by pathology. The distinction of VX-2 tumors on DWI was assessed by their apparent diffusion coefficient (ADC) values. The statistical significance between different time groups, different area groups or different b-value groups was calculated by using SPSS12.0 software. RESULTS: Under b-value of 100 s/mm2, ADC values were lowest at 16 h after chemoembolization in area of VX-2 tumor periphery, central, and normal liver parenchyma around tumor, but turned to increase with further elongation of chemoembolization treatment. The distinction of ADC between different time groups was significant respectively (F = 7.325, P < 0.001; F = 2.496, P < 0.048; F = 6.856, P < 0.001). Cellular edema in the area of VX-2 tumor periphery or normal liver parenchyma around tumor, increased quickly in sixteen h after chemoembolization but, from the 16th h to the 48th h, cellular edema in the area of normal liver parenchyma around tumor decreased gradually and that in the area of VX-2 tumor periphery decreased lightly at, and then increased continually. After chemoembolization, Cellular necrosis in the area of VX-2 tumor periphery was more significantly high than that before chemoembolization. The areas of dead cells in VX-2 tumors manifested low signal and high ADC value, while the areas of viable cells manifested high signal and low ADC value. CONCLUSION: DWI is able to detect and differentiate tumor necrotic areas from viable cellular areas before and after chemoembolization. ADC of normal liver parenchyma and VX-2 tumor are influenced by intracellular edema, tissue cellular death and microcirculation disturbance after chemoembolization. 展开更多
关键词 Liver VX-2 tumor Diffusion-weighted imaging Apparent diffusion coefficient Chemoembolization
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Apparent diffusion coefficient by diffusion-weighted magnetic resonance imaging as a sole biomarker for staging and prognosis of gastric cancer 认领 引用 被引量：17
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作者 Francesco Giganti Alessandro Ambrosi +7 位作者 Damiano Chiari Elena Orsenigo Antonio Esposito Elena Mazza Luca Albarello Carlo Staudacher Alessandro Del Maschio Francesco De Cobelli 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2017年第2期118-126,共9页
Objective： To investigate the role of apparent diffusion coefficient （ADC） from diffusion-weighted magnetic resonance imaging （DW-MRI） when applied to the 7th TNM classification in the staging and prognosis of ga... Objective： To investigate the role of apparent diffusion coefficient （ADC） from diffusion-weighted magnetic resonance imaging （DW-MRI） when applied to the 7th TNM classification in the staging and prognosis of gastric cancer （GC）. Methods： Between October 2009 and May 2014, a total of 89 patients with non-metastatic, biopsy proven GC underwent 1.5T DW-MRI, and then treated with radical surgery. Tumor ADC was measured retrospectively and compared with final histology following the 7th TNM staging （local invasion, nodal involvement and according to the different groups -- stage Ⅰ, Ⅱ and Ⅲ）. Kaplan-Meier curves were also generated. The follow-up period is updated to May 2016. Results： Median follow-up period was 33 months and 45/89 （51%） deaths from GC were observed. ADC was significantly different both for local invasion and nodal involvement （P〈0.001）. Considering final histology as the reference standard, a preoperative ADC cut-offof 1.80×10-3 mm^2/s could distinguish between stages I and Ⅱ and an ADC value of ≤1.36-10-3 mm^2/s was associated with stage Ⅲ（P〈0.001）. Kaplan-Meier curves demonstrated that the survival rates for the three prognostic groups were significantly different according to final histology and ADC cut-offs （P〈0.001）. Conclusions： ADC is different according to local invasion, nodal involvement and the 7th TNM stage groups for GC, representing a potential, additional prognostic biomarker. The addition of DW-MRI could aid in the staging and risk stratification of GC. 展开更多
关键词 Apparent diffusion coefficient diffusion-weighted magnetic resonance imaging gastric cancer prognosis TNM staging
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Dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging in the activity staging of terminal ileum Crohn's disease 认领 引用 被引量：9
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作者 Yin-Chen Wu Ze-Bin Xiao +3 位作者 Xue-Hua Lin Xian-Ying Zheng Dai-Rong Cao Zhong-Shuai Zhang 《World Journal of Gastroenterology》 SCIE CAS 2020年第39期6057-6073,共17页
BACKGROUND The activity staging of Crohn’s disease(CD)in the terminal ileum is critical in developing an accurate clinical treatment plan.The activity of terminal ileum CD is associated with the microcirculation of i... BACKGROUND The activity staging of Crohn’s disease(CD)in the terminal ileum is critical in developing an accurate clinical treatment plan.The activity of terminal ileum CD is associated with the microcirculation of involved bowel walls.Dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)and diffusionweighted imaging(DWI)can reflect perfusion and permeability of bowel walls by providing microcirculation information.As such,we hypothesize that DCE-MRI and DWI parameters can assess terminal ileum CD,thereby providing an opportunity to stage CD activity.AIM To evaluate the value of DCE-MRI and DWI in assessing activity of terminal ileum CD.METHODS Forty-eight patients with CD who underwent DCE-MRI and DWI were enrolled.The patients’activity was graded as remission,mild and moderate-severe.The transfer constant(Ktrans),wash-out constant(Kep),and extravascular extracellular volume fraction(Ve)were calculated from DCE-MRI and the apparent diffusion coefficient(ADC)was obtained from DWI.Magnetic Resonance Index of Activity(MaRIA)was calculated from magnetic resonance enterography.Differences in these quantitative parameters were compared between normal ileal loop(NIL)and inflamed terminal ileum(ITI)and among different activity grades.The correlations between these parameters,MaRIA,the Crohn’s Disease Activity Index(CDAI),and Crohn’s Disease Endoscopic Index of Severity(CDEIS)were examined.Receiver operating characteristic curve analyses were used to determine the diagnostic performance of these parameters in differentiating between CD activity levels.RESULTS Higher Ktrans(0.07±0.04 vs 0.01±0.01),Kep(0.24±0.11 vs 0.15±0.05)and Ve(0.27±0.07 vs 0.08±0.03),but lower ADC(1.41±0.26 vs 2.41±0.30)values were found in ITI than in NIL(all P<0.001).The Ktrans,Kep,Ve and MaRIA increased with disease activity,whereas the ADC decreased(all P<0.001).The Ktrans,Kep,Ve and MaRIA showed positive correlations with the CDAI(r=0.866 for Ktrans,0.870 for Kep,0.858 for Ve,0.890 for MaRIA,all P<0.001)and CDEIS(r=0.563 for Ktrans,0.567 for Kep,0.571 for Ve,0.842 for MaRIA,all P<0.001),while the ADC showed negative correlations with the CDAI(r=-0.857,P<0.001)and CDEIS(r=-0.536,P<0.001).The areas under the curve(AUC)for the Ktrans,Kep,Ve,ADC and MaRIA values ranged from 0.68 to 0.91 for differentiating inactive CD(CD remission)from active CD(mild to severe CD).The AUC when combining the Ktrans,Kep and Ve was 0.80,while combining DCE-MRI parameters and ADC values yielded the highest AUC of 0.95.CONCLUSION DCE-MRI and DWI parameters all serve as measures to stage CD activity.When they are combined,the assessment performance is improved and better than MaRIA. 展开更多
关键词 Crohn’s disease Ileum Magnetic resonance imaging Diffusion-weighted imaging Perfusion imaging
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Diffusion-weighted magnetic resonance imaging for predicting the response of rectal cancer to neoadjuvant concurrent chemoradiation 认领 引用 被引量：11
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作者 Gang Cai Ye Xu +5 位作者 Ji Zhu Wei-Lie Gu Shuai Zhang Xue-Jun Ma San-Jun Cai Zhen Zhang 《World Journal of Gastroenterology》 SCIE CAS 2013年第33期5520-5527,共8页
AIM:To evaluate the clinical value of diffusion-weighted magnetic resonance imaging(DW-MRI)in predicting the response of rectal cancer to neoadjuvant chemoradiation.METHODS:This prospective study was approved by our i... AIM:To evaluate the clinical value of diffusion-weighted magnetic resonance imaging(DW-MRI)in predicting the response of rectal cancer to neoadjuvant chemoradiation.METHODS:This prospective study was approved by our institutional review board,and informed consent was obtained from each patient.Fifteen patients(median age 56 years)with locally advanced rectal cancer were treated in our hospital from June 2006 to December 2007.All patients were stageⅢB-C according to the results of MRI and endorectal ultrasound examinations.All patients underwent pelvic irradiation with 45 Gy/25 fx per 35 days.The concurrent chemotherapy regimen consisted of capecitabine 625mg/m2,bid(Monday-Friday),and oxaliplatin 50 mg/m2,weekly.The patients underwent surgery 5-8 wk after the completion of neoadjuvant therapy.T downstaging was defined as the downstaging of the tumor from cT3to ypT0-2 or from cT4 to ypT0-3.Good regression was defined as TRG 3-4,and poor regression was defined as TRG 0-2.Diffusion-weighted magnetic resonance images were obtained prior to and weekly during the course of neoadjuvant chemoradiation,and the apparent diffusion coefficient(ADC)values were calculated from the acquired tumor images.RESULTS:Comparison with the mean pretreatment tumor ADC revealed an increase in the mean tumor ADC during the course of neoadjuvant chemoradiation,especially at the 2ndweek(P=0.004).We found a strong negative correlation between the mean pretreatment tumor ADC and tumor regression after neoadjuvant chemoradiation(P=0.021).In the T downstage and tumor regression groups,we found a significant increase in the mean ADC at the 2ndweek of neoadjuvant therapy(P=0.011;0.004).CONCLUSION:DW-MRI might be a valuable clinical tool to help predict or assess the response of rectal cancer to neoadjuvant chemoradiation at an early timepoint. 展开更多
关键词 Locally advanced rectal cancer Neoadjuvant chemoradiation Diffusion-weighted magnetic resonance imaging Apparent diffusion coefficient
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Quantitative differentiation of malignant and benign thyroid nodules with multi-parameter diffusion-weighted imaging 认领 引用 被引量：10
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作者 Xiang Zhu Jia Wang +5 位作者 Yan-Chun Wang Ze-Feng Zhu Jian Tang Xiao-Wei Wen Ying Fang Jun Han 《World Journal of Clinical Cases》 SCIE 2022年第24期8587-8598,共12页
BACKGROUND The value of conventional magnetic resonance imaging in the differential diagnosis of thyroid nodules is limited;however,the value of multi-parameter diffusion-weighted imaging(DWI)in the quantitative evalu... BACKGROUND The value of conventional magnetic resonance imaging in the differential diagnosis of thyroid nodules is limited;however,the value of multi-parameter diffusion-weighted imaging(DWI)in the quantitative evaluation of thyroid nodules has not been well determined.AIM To determine the utility of multi-parametric DWI including mono-exponential,biexponential,stretched exponential,and kurtosis models for the differentiation of thyroid lesions.METHODS Seventy-nine patients(62 with benign and 17 with malignant nodules)underwent multi-b value diffusion-weighted imaging of the thyroid.Multiple DWI parameters were obtained for statistical analysis.RESULTS Good agreement was found for diffusion parameters of thyroid nodules.Malignant lesions displayed lower diffusion parameters including apparent diffusion coefficient(ADC),the true diffusion coefficient(D),the perfusion fraction(f),the distributed diffusion coefficient(DDC),the intravoxel water diffusion heterogeneity(α)and kurtosis model-derived ADC(Dapp),and higher apparent diffusional kurtosis(Kapp)than benign entities(all P0.05).The area under the ROC curve(AUC)of the ADC(0 and 1000)was not significantly different from that of the ADC(0 and 2000),ADC(0 to 2000),ADC(0 to 1000),D,DDC,Dapp and Kapp(all P>0.05),but was significantly higher than the AUC of D*,f andα(all P<0.05)for differentiating benign from malignant lesions.CONCLUSION Multiple DWI parameters including ADC,D,f,DDC,α,Dapp and Kapp could discriminate benign and malignant thyroid nodules.The metrics including D,DDC,Dapp and Kapp provide additional information with similar diagnostic performance of ADC,combination of these metrics may contribute to differentiate benign and malignant thyroid nodules.The ADC calculated with higher b values may not lead to improved diagnostic performance. 展开更多
关键词 Thyroid nodule Magnetic resonance imaging Diffusion-weighted imaging Quantitative study Sensitivity Specificity
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Abdominal applications of diffusion-weighted magnetic resonance imaging:Where do we stand? 认领 引用 被引量：19
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作者 Ajaykumar C Morani Khaled M Elsayes +6 位作者 Peter S Liu William J Weadock Janio Szklaruk Jonathan Russell Dillman Asra Khan Thomas L Chenevert Hero K Hussain 《World Journal of Radiology》 2013年第3期68-80,共13页
Diffusion-weighted imaging(DWI)is one of the magnetic resonance imaging(MRI)sequences providing qualitative as well as quantitative information at a cellular level.It has been widely used for various applications in t... Diffusion-weighted imaging(DWI)is one of the magnetic resonance imaging(MRI)sequences providing qualitative as well as quantitative information at a cellular level.It has been widely used for various applications in the central nervous system.Over the past decade,various extracranial applications of DWI have been increasingly explored,as it may detect changes even before signal alterations or morphological abnormalities become apparent on other pulse sequences.Initial results from abdominal MRI applications are promising,particularly in oncological settings and for the detection of abscesses.The purpose of this article is to describe the clinically relevant basic concepts of DWI,techniques to perform abdominal DWI,its analysis and applications in abdominal visceral MR imaging,in addition to a brief overview of whole body DWI MRI. 展开更多
关键词 Diffusion-weighted imaging Imaging Diffusion
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Evaluating the efficacy of interventional hepatocellular carcinoma via dynamic contrast-enhanced magnetic resonance imaging:A retrospective study 认领 引用
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作者 Ying-Hua Huang Xin-Liang Liu Zhao Yang 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第6期141-149,共9页
BACKGROUND Hepatocellular carcinoma(HCC)is a common malignant tumor.Early diagnosis and treatment are crucial for improving patient prognosis.Interventional therapy is an important treatment method for HCC.Dynamic con... BACKGROUND Hepatocellular carcinoma(HCC)is a common malignant tumor.Early diagnosis and treatment are crucial for improving patient prognosis.Interventional therapy is an important treatment method for HCC.Dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI),an effective imaging assessment technique,can monitor changes in tumor blood flow in real time and provide important information for evaluating treatment effects.AIM To determine the clinical effectiveness of diffusion-weighted imaging(DWI)in conjunction with DCE-MRI in evaluating the therapeutic response to interventional therapy for HCC.METHODS Between February 2023 and March 2024,120 HCC patients who received interventional therapy at First Affiliated Hospital of Naval Military Medical University were retrospectively analyzed.Patients were divided into two groups:(1)71 received effective treatment;and(2)49 received ineffective treatment.Fifty-two males and 19 females,with an average age of 53.16±8.47 years,composed the effective group.The mean age of the ineffective group,which consisted of 18 females and 31 males,was 53.21±8.69 years.All patients had regular MRI,DCEMRIs,and DWIs taken before and three weeks after the intervention.The tumor volume,extracellular volume fraction(Ve),transport constant(Ktrans),apparent diffusion coefficient(ADC),and rate constant(Kep)are among the important imaging parameters that were examined.RESULTS The ADC significantly increased to(1.23±0.14)×10-3 mm2/second(t=10.970,P<0.05),the tumor volume decreased to 10.67±2.48 cm3(t=26.683,P<0.05),the Ktrans significantly decreased to 0.18±0.07 minute-1(t=9.090,P<0.05),the Kep significantly decreased to 0.31±0.06 minute-1(t=11.829,P<0.05),and the Ve significantly increased to 0.40±0.05(t=6.252,P<0.05)following the intervention.The ADC[(0.35±0.08)×10-3 mm2/second],Ktrans(0.24±0.06 minute-1),Kep(0.47±0.12 minute-1),Ve(0.46±0.13),and tumor volume(10.57±2.34 cm3)substantially differed between the effective treatment group and the ineffective group(all P<0.05).According to the receiver operating characteristic(ROC)analysis,therapeutic success was predicted by an ADC difference greater than 0.380×10-3 mm2/second,with an area under the ROC curve of 0.953(95%CI:0.898-0.983,P<0.001),a sensitivity of 91.84%,and a specificity of 91.55%.With a sensitivity and specificity of 89.80%and 88.73%,respectively,an area under the ROC curve of 0.933(95%CI:0.872-0.970,P<0.001)was obtained for a Ktrans difference greater than 0.250 minute-1.CONCLUSION There is substantial clinical relevance in combining DCE-MRI with DWI to assess how well HCC patients respond to interventional treatments.For patients with HCC,changes in imaging parameters before and after treatment offer objective information that shows the effectiveness of the therapy and can direct future clinical management and treatment planning. 展开更多
关键词 Liver cancer Enhanced magnetic resonance Diffusion-weighted imaging Interventional therapy Application value
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Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models 认领 引用 被引量：14
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作者 Yan-Li Jiang Juan Li +6 位作者 Peng-Fei Zhang Feng-Xian Fan Jie Zou Pin Yang Peng-Fei Wang Shao-Yu Wang Jing Zhang 《World Journal of Gastroenterology》 SCIE CAS 2024年第9期1164-1176,共13页
BACKGROUND Diffusion-weighted imaging(DWI)has been developed to stage liver fibrosis.However,its diagnostic performance is inconsistent among studies.Therefore,it is worth studying the diagnostic value of various diff... BACKGROUND Diffusion-weighted imaging(DWI)has been developed to stage liver fibrosis.However,its diagnostic performance is inconsistent among studies.Therefore,it is worth studying the diagnostic value of various diffusion models for liver fibrosis in one cohort.AIM To evaluate the clinical potential of six diffusion-weighted models in liver fibrosis staging and compare their diagnostic performances.METHODS This prospective study enrolled 59 patients suspected of liver disease and scheduled for liver biopsy and 17 healthy participants.All participants underwent multi-b value DWI.The main DWI-derived parameters included Mono-apparent diffusion coefficient(ADC)from mono-exponential DWI,intravoxel incoherent motion model-derived true diffusion coefficient(IVIM-D),diffusion kurtosis imaging-derived apparent diffusivity(DKI-MD),stretched exponential model-derived distributed diffusion coefficient(SEM-DDC),fractional order calculus(FROC)model-derived diffusion coefficient(FROC-D)and FROC model-derived microstructural quantity(FROC-μ),and continuous-time random-walk(CTRW)model-derived anomalous diffusion coefficient(CTRW-D)and CTRW model-derived temporal diffusion heterogeneity index(CTRW-α).The correlations between DWI-derived parameters and fibrosis stages and the parameters’diagnostic efficacy in detecting significant fibrosis(SF)were assessed and compared.RESULTS CTRW-D(r=-0.356),CTRW-α(r=-0.297),DKI-MD(r=-0.297),FROC-D(r=-0.350),FROC-μ(r=-0.321),IVIM-D(r=-0.251),Mono-ADC(r=-0.362),and SEM-DDC(r=-0.263)were significantly correlated with fibrosis stages.The areas under the ROC curves(AUCs)of the combined index of the six models for distinguishing SF(0.697-0.747)were higher than each of the parameters alone(0.524-0.719).The DWI models’ability to detect SF was similar.The combined index of CTRW model parameters had the highest AUC(0.747).CONCLUSION The DWI models were similarly valuable in distinguishing SF in patients with liver disease.The combined index of CTRW parameters had the highest AUC. 展开更多
关键词 Liver fibrosis Magnetic resonance imaging Diffusion-weighted magnetic resonance Liver biopsy Significant fibrosis
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Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization 认领 引用 被引量：13
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作者 Johnathan C Chung Nee K Naik +8 位作者 Robert J Lewandowski Jie Deng Mary F Mulcahy Laura M Kulik Kent T Sato Robert KRyu Riad Salem Andrew C Larson Reed A Omary 《World Journal of Gastroenterology》 SCIE CAS 2010年第25期3161-3167,共7页
AIM:To investigate whether intra-procedural diffusion-weighted magnetic resonance imaging can predict response of hepatocellular carcinoma(HCC)during trans-catheter arterial chemoembolization(TACE).METHODS:Sixteen pat... AIM:To investigate whether intra-procedural diffusion-weighted magnetic resonance imaging can predict response of hepatocellular carcinoma(HCC)during trans-catheter arterial chemoembolization(TACE).METHODS:Sixteen patients(15 male),aged 59±11 years(range:42-81 years)underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite.Ana-tomical imaging and diffusion-weighted imaging(b=0,500 s/mm2)were performed on a 1.5-T unit.Tumor enhancement and apparent diffusion coefficient(ADC,mm2/s)values were assessed immediately before and at 1 and 3 mo after TACE.We calculated the percent change(PC)in ADC values at all time points.We compared follow-up ADC values to baseline values using a paired t test(α=0.05).RESULTS:The intra-procedural sensitivity,specificity,and positive and negative predictive values(%)for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of±5%,±10%,and±15%were 77,67,91,and 40;54,67,88,and 25;and 46,100,100,and 30,respectively.There was no clear predictive value for the 3-mo follow-up.Compared to baseline,the immediate post-procedure and 1-mo mean ADC values both increased;the latter obtaining statistical significance(1.48±0.29 mm2/s vs 1.65±0.35×10-3 mm2/s,P15%predicted 1-mo anatomical HCC response with the greatest accuracy,and can provide valuable feedback at the time of TACE. 展开更多
关键词 Hepatocellular carcinoma Transcatheter arterial chemoembolization Diffusion-weighted imaging Apparent diffusion coefficient Functional imaging biomarker
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Gene expression and MR diffusion-weighted imaging after chemoembolization in rabbit liver VX-2 tumor model 认领 引用 被引量：6
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作者 You-Hong Yuan En-Hua Xiao +6 位作者 Jian-Bin Liu Zhong He Ke Jin Cong Ma Jun Xiang Jian-Hua Xiao Wei-Jian Chen 《World Journal of Gastroenterology》 SCIE CAS 2008年第36期5557-5563,共7页
AIM: To investigate the dynamic characteristics and the correlation between PCNA, Bax, nm23, E-cadherin expression and apparent diffusion coefficient (ADC) on MR diffusion-weighted imaging (DWI) after chemoembolizatio... AIM: To investigate the dynamic characteristics and the correlation between PCNA, Bax, nm23, E-cadherin expression and apparent diffusion coefficient (ADC) on MR diffusion-weighted imaging (DWI) after chemoembolization in rabbit liver VX-2 tumor model. METHODS: Forty New Zealand rabbit liver VX-2 tumor models were included in the study. DWI was carried out periodically after chemoembolization. All VX-2 tumor samples in each group were examined by histopathology and Strept Avidin-Biotin Complex (SABC) immunohistochemical staining. RESULTS: The PCNA expression index in VX-2 tumors was higher than in the normal parenchyma around the tumor (P < 0.001). Nm23, Bax or E-caderin expression index in VX-2 tumors were lower than in the normal parenchyma around the tumor (all P < 0.001). PCNAand nm23 expression in the VX-2 tumor periphery first increased and then decreased (P < 0.001 and P = 0.03, respectively), while the expression of Bax and E-cadherin before and after chemoembolization was insignificant. When b-value was 100 s/mm2, there was a linear correlation between PCNA expression and ADC in the area of VX-2 tumor periphery (P < 0.001), and PCNA expression in VX-2 tumor periphery influenced the ADC. CONCLUSION: The potential of VX-2 tumor infiltrating and metastasizing decreases, while its ability to proliferate increases for a short time after chemoembolization. To some degree, the ADC value indirectly reflects the proliferation of VX-2 tumor cells. 展开更多
关键词 Rabbit liver VX-2 tumor Chemoembolization Diffusion-weighted imaging Gene expression
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Optimal b value of diffusion-weighted imaging on a 3.0T magnetic resonance scanner in Crohn's disease 认领 引用 被引量：4
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作者 Qi Feng Yun-Qi Yan +2 位作者 Jiong Zhu Jin-Lu Tong Jian-Rong Xu 《World Journal of Gastroenterology》 SCIE CAS 2014年第35期12621-12627,共7页
AIM: To determine the optimal b value of diffusion-weighted imaging for detecting active inflammation in Crohn&#x02019;s disease.
关键词 Crohn’ s disease Diffusion-weighted imaging b value Magnetic resonance image 3.0 Tesla
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