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Evolving prokinetic therapy:New targets and therapeutic opportunities in gastrointestinal motility disorders 认领 引用
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作者 Omesh Goyal Rishi Chowdhary +8 位作者 Tanisha Sehgal Tanvi Joshi Akshit Bhambri Insiya Mohammed Rampurawala Gurmanleen Singh Sohi Arghadip Das Kirti Arora Ashita Rukmini Vuthaluru Manjeet Kumar Goyal 《World Journal of Gastrointestinal Pharmacology and Therapeutics》 2026年第2期43-56,共14页
Gastroparesis,functional dyspepsia,chronic constipation,esophageal motility disorders,and colonic dysmotility are among the gastrointestinal(GI)motility disorders that constitute a significant global health burden.The... Gastroparesis,functional dyspepsia,chronic constipation,esophageal motility disorders,and colonic dysmotility are among the gastrointestinal(GI)motility disorders that constitute a significant global health burden.These disorders lead to reduced quality of life,higher healthcare utilization,and substantial socioeconomic costs.Therapeutic options are still scarce despite their prevalence.Prokinetic medications currently on the market offer only modest symptomatic relief,frequently reaching a plateau in efficacy,and their long-term use is limited by safety concerns,especially those related to cardiovascular and neurological side effects,as well as limited regional availability of some agents.The conceptual framework has moved beyond a purely neurocentric model due to recent advances in our understanding of GI motor physiology.The integrated functions of enteric neurobiology,gut-brain axis signaling,smooth muscle contractile pathways,interstitial cells of Cajal as motility pacemakers,and neuromodulatory circuits are highlighted by emerging mechanistic insights.These advancements have made it easier to find new pharmacologic targets and treatment approaches.An overview of new classes of prokinetic and motility-modulating drugs,such as selective receptor agonists and antagonists,hormone-based treatments,neuromodulators,and drugs that target pacemaker cell and smooth muscle function,is given in this review.Lastly,the clinical ramifications of these developing treatments are examined,with a focus on individualized treatment plans and potential future paths to enhance GI motility disorder efficacy,safety,and disease-specific management. 展开更多
关键词 Gastrointestinal motility disorders Prokinetic agents Gastroparesis Dyspepsia Constipation Disorders of gut brain interaction Functional gastrointestinal disorders Enteric nervous system Serotonin receptor agonists Dopamine antagonists Ghrelin
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Enteric nervous system disease in neuronopathic lysosomal storage disorders 认领 引用
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作者 Ewa A.Ziołkowska Robert O.Heuckeroth Jonathan D.Cooper 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3537-3538,共2页
Lysosomal storage disorders and their impact upon the central nervous system:Lysosomal storage disorders(LSDs)are a group of over 70 rare inherited metabolic disorders(Platt et al.,2018).They are caused by dysfunction... Lysosomal storage disorders and their impact upon the central nervous system:Lysosomal storage disorders(LSDs)are a group of over 70 rare inherited metabolic disorders(Platt et al.,2018).They are caused by dysfunction of lysosomes,organelles that contain enzymes responsible for digesting macromolecules.In functional lysosomes,these enzymes break down complex substrates,and the resulting fragments are recycled.Individual LSDs are caused by mutations in genes that encode lysosomal enzymes or other proteins crucial for lysosome function(Platt et al.,2018). 展开更多
关键词 break down complex substratesand neuronopathic lysosomal storage disorders lysosomal storage disorders storage disorders lsds digesting macromoleculesin lysosomal enzymes enteric nervous system central nervous system
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Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders 认领 引用
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作者 Zhiqin Deng Zhe Zhao +6 位作者 Wenting Jiang Xiaoqiang Chen Jianquan Liu Xu Tao Zhengyang Lin Zhenhan Deng Wencui Li 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第5期932-946,共15页
Background:This study aimed to investigate the potential causal relationship be-tween genetically predicted human blood cell(HBC)reactivity and disorders of bone continuity,density,and structure.Methods:We analyzed su... Background:This study aimed to investigate the potential causal relationship be-tween genetically predicted human blood cell(HBC)reactivity and disorders of bone continuity,density,and structure.Methods:We analyzed summary-level GWAS data for 91 HBC traits and two bone-related outcomes from publicly available sources,employing the inverse-variance weighted(IVW)method as the principal Mendelian randomization(MR)technique.The sensitivity analyses comprised MR-Egger regression and MR-PRESSO.Results:MR analysis identified suggestive associations between red blood cell(RBC)perturbation response(Pam3CSK4),neutrophil perturbation response(side fluores-cence coefficient of variation of neutrophil 4),Neutrophil perturbation response(col-chicine),Monocyte perturbation response(TMAO perturbation)and bone continuity.The MR results are:[β:−0.13,odds ratio(OR):0.88;95%confidence interval(CI):0.77,0.99;p=0.040],[β:0.11,OR:1.12,95%CI:1.02,1.23;p=0.016],[β:−0.11,OR:0.90,95%CI:0.81,0.99;p=0.029]and[β:−0.04,OR:0.96,95%CI:0.92,0.99;p=0.023].In addition,Neutrophil perturbation response(forward scatter median of neutrophil 1),Unknown cell population perturbation response(nigericin)and other disorders of bone density and structure are also potential causal factors,with MR Result[β:0.21,OR:1.24,95%CI:1.01,1.51;p=0.034],[β:0.03,OR:1.03,95%CI:1.00,1.06;p=0.042].Reverse Mendelian randomization sensitivity analysis showed a potential bidirectional association between specific HBC features and bone-related outcomes.Conclusions:This exploratory study offer valuable preliminary insights into the blood cell functional reactivity and bone health.The findings,while requiring independent validation,highlight plausible biological pathways for further elucidation. 展开更多
关键词 disorders of bone continuity disorders of bone density and structure human blood cell Mendelian randomization osteoporosis
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Mitochondrial dynamics dysfunction and neurodevelopmental disorders:From pathological mechanisms to clinical translation 认领 引用 被引量：4
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作者 Ziqi Yang Yiran Luo +5 位作者 Zaiqi Yang Zheng Liu Meihua Li Xiao Wu Like Chen Wenqiang Xin 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期1926-1946,共21页
Mitochondrial dysfunction has emerged as a critical factor in the etiology of various neurodevelopmental disorders, including autism spectrum disorders, attention-deficit/hyperactivity disorder, and Rett syndrome. Alt... Mitochondrial dysfunction has emerged as a critical factor in the etiology of various neurodevelopmental disorders, including autism spectrum disorders, attention-deficit/hyperactivity disorder, and Rett syndrome. Although these conditions differ in clinical presentation, they share fundamental pathological features that may stem from abnormal mitochondrial dynamics and impaired autophagic clearance, which contribute to redox imbalance and oxidative stress in neurons. This review aimed to elucidate the relationship between mitochondrial dynamics dysfunction and neurodevelopmental disorders. Mitochondria are highly dynamic organelles that undergo continuous fusion and fission to meet the substantial energy demands of neural cells. Dysregulation of these processes, as observed in certain neurodevelopmental disorders, causes accumulation of damaged mitochondria, exacerbating oxidative damage and impairing neuronal function. The phosphatase and tensin homolog-induced putative kinase 1/E3 ubiquitin-protein ligase pathway is crucial for mitophagy, the process of selectively removing malfunctioning mitochondria. Mutations in genes encoding mitochondrial fusion proteins have been identified in autism spectrum disorders, linking disruptions in the fusion-fission equilibrium to neurodevelopmental impairments. Additionally, animal models of Rett syndrome have shown pronounced defects in mitophagy, reinforcing the notion that mitochondrial quality control is indispensable for neuronal health. Clinical studies have highlighted the importance of mitochondrial disturbances in neurodevelopmental disorders. In autism spectrum disorders, elevated oxidative stress markers and mitochondrial DNA deletions indicate compromised mitochondrial function. Attention-deficit/hyperactivity disorder has also been associated with cognitive deficits linked to mitochondrial dysfunction and oxidative stress. Moreover, induced pluripotent stem cell models derived from patients with Rett syndrome have shown impaired mitochondrial dynamics and heightened vulnerability to oxidative injury, suggesting the role of defective mitochondrial homeostasis in these disorders. From a translational standpoint, multiple therapeutic approaches targeting mitochondrial pathways show promise. Interventions aimed at preserving normal fusion-fission cycles or enhancing mitophagy can reduce oxidative damage by limiting the accumulation of defective mitochondria. Pharmacological modulation of mitochondrial permeability and upregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha, an essential regulator of mitochondrial biogenesis, may also ameliorate cellular energy deficits. Identifying early biomarkers of mitochondrial impairment is crucial for precision medicine, since it can help clinicians tailor interventions to individual patient profiles and improve prognoses. Furthermore, integrating mitochondria-focused strategies with established therapies, such as antioxidants or behavioral interventions, may enhance treatment efficacy and yield better clinical outcomes. Leveraging these pathways could open avenues for regenerative strategies, given the influence of mitochondria on neuronal repair and plasticity. In conclusion, this review indicates mitochondrial homeostasis as a unifying therapeutic axis within neurodevelopmental pathophysiology. Disruptions in mitochondrial dynamics and autophagic clearance converge on oxidative stress, and researchers should prioritize validating these interventions in clinical settings to advance precision medicine and enhance outcomes for individuals affected by neurodevelopmental disorders. 展开更多
关键词 autophagic clearance autism spectrum disorders cellular homeostasis fusion and fission mitochondrial dynamics mitophagy neural regeneration neuronal energy metabolism neurodevelopmental disorders oxidative stress
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Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders:a genome-wide association study and multi-ancestry validation in schizophrenia 认领 引用 被引量：1
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作者 Zhe Lu Yao-Yao Sun +5 位作者 Zhe-Wei Kang Guo-Rui Zhao Yu-Yanan Zhang Jun-Yuan Sun Rui Yuan Wei-Hua Yue 《Military Medical Research》 SCIE CAS CSCD 2026年第2期185-197,共13页
Background:Antipsychotic-induced movement disorders(AIMDs)are prevalent side effects of antipsychotics,particularly during the acute phase of treatment.This study aimed to elucidate the genetic mechanisms underlying A... Background:Antipsychotic-induced movement disorders(AIMDs)are prevalent side effects of antipsychotics,particularly during the acute phase of treatment.This study aimed to elucidate the genetic mechanisms underlying AIMDs using a genome-wide association study(GWAS).Methods:GWASs on AIMDs were conducted in three independent cohorts:a discovery cohort of 3067 patients(2016 subjects were reserved after quality control),a validation cohort of 277 patients,and a multi-ancestry validation cohort of 766 patients.Subsequent post-GWAS analyses included gene-based analyses,transcriptome-wide association studies(TWASs),and polygenic risk score(PRS)profiling.Results:Our study identified two loci located in RAB44 gene(rs116249243,P=5.98×10-9;rs117097482,P=1.17×10-8)associated with extrapyramidal symptoms(EPSs),1 locus(rs6826172,P=5.56×10-9)related to akathisia,and 76 loci linked to involuntary movements(11 genes were mapped).Risk loci located in CNTNAP2,LUZP2,TMEM167A,and RAB44 genes were successfully replicated in the validation cohort,whereas the locus located in RAB44 was also replicated in the multi-ancestry cohort.Gene-based analyses indicated that XRCC4 and PAIP2B reached significance at the genome-wide level in involuntary movements.Tissue expression analysis revealed that involuntary movement-related genes are predominantly expressed in the substantia nigra.Additionally,the TWAS suggested a causal relationship between XRCC4 and involuntary movement.The PRSs derived from the discovery cohort significantly predicted AIMDs in the validation cohort,with area under the receiver operating characteristic curve(AUC)values from 0.60 to 0.80.Conclusions:Our findings highlight the role of substantia nigra related gene polymorphisms in AIMDs.This study provides novel insights into the pathogenesis of AIMDs and supports the potential for personalized treatment approaches for schizophrenia. 展开更多
关键词 Antipsychotic Movement disorders Genome-wide association study(GWAS) Substantia nigra Multiancestry validation
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PET Molecular Imaging of the Endocannabinoid System in Psychiatric Disorders 认领 引用 被引量：1
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作者 Chunyi Cui Xiaofeng Dou +7 位作者 Peili Cen Chentao Jin Jing Wang Jiaqi Niu Chenxi Xue Mei Tian Hong Zhang Yan Zhong 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第2期419-438,共20页
Psychiatric disorders have emerged as significant contributors to the global burden of disease in recent decades.The endocannabinoid system(ECS)influences a range of physiological and pathophysiological processes,incl... Psychiatric disorders have emerged as significant contributors to the global burden of disease in recent decades.The endocannabinoid system(ECS)influences a range of physiological and pathophysiological processes,including nociception,cognition,appetite,memory,and behavior,serving as a crucial mediator in psychiatric disorders.Imaging the ECS provides valuable insights into the pathophysiological mechanisms underlying psychiatric disorders and enhances clinical management strategies.As an advanced noninvasive molecular imaging modality,positron emission tomography(PET)enables the in vivo exploration of biological processes at the cellular and molecular levels.Recent advancements have led to the development of numerous PET tracers that target various components of the ECS,offering opportunities to visualize,characterize,and quantify ECS activity in psychiatric disorders in vivo.In this review,we summarize the existing PET tracers for ECS imaging and discuss their applications in diverse psychiatric conditions,including cannabis use disorder,alcohol use disorder,post-traumatic stress disorder,schizophrenia,and eating disorders. 展开更多
关键词 Positron emission tomography(PET).Psychiatric disorders Cannabinoid receptors Fatty acid amide hydrolase Monoacylglycerol lipase
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Photobiomodulation and Addiction:Exploring Mechanisms,Therapeutic Potential,and Future Directions in Substance Use Disorders 认领 引用
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作者 Xiujiao Qin Hongyuan Li +1 位作者 Huiying Zhao Xiaohui Wang 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第2期471-475,共5页
Addiction,a complex and chronic neurobiological disorder,is characterized by compulsive substance use despite harmful consequences,leading to persistent alterations in brain function,particularly within the reward,mot... Addiction,a complex and chronic neurobiological disorder,is characterized by compulsive substance use despite harmful consequences,leading to persistent alterations in brain function,particularly within the reward,motivation,and decision-making systems.Despite the availability of a range of treatment options,including pharmacotherapy and behavioral therapies,relapse remains a major challenge,with many individuals struggling to maintain long-term recovery.Current treatments often show limited efficacy,underscoring the need for novel therapeutic strategies that can address the underlying neurobiological disruptions in addiction. 展开更多
关键词 photobiomodulation motivation behavioral therapiesrelapse therapeutic potential substance use disorders neurobiological disorder mechanisms addiction
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Intermittent Hypoxia-Hyperoxia Training Ameliorates Symptoms and Improves Cerebral Perfusion Status in Patients with Cerebral Venous Outflow Disorders:A Pilot Study 认领 引用
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作者 Milan Jia Chenxia Zhou +8 位作者 Hui Li Jing Lan Wenbo Zhao Lingyun Jia Sijie Li Changhong Ren Chen Zhou Lu Liu Xunming Ji 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第2期192-201,共10页
Objective Cerebral venous outflow disorders(CVOD)can impair cerebral perfusion and produce diverse,often debilitating symptoms,substantially reducing quality of life.Intermittent hypoxiahyperoxia training(IHHT)has dem... Objective Cerebral venous outflow disorders(CVOD)can impair cerebral perfusion and produce diverse,often debilitating symptoms,substantially reducing quality of life.Intermittent hypoxiahyperoxia training(IHHT)has demonstrated therapeutic potential across various pathologies and may represent a promising non-pharmacological approach for CVOD management.Methods Patients with imaging-confirmed CVOD underwent 14 IHHT sessions,each comprising four cycles of 10-minute hypoxia(11%O2)stimulation and 20-minute hyperoxia(38%O2).Physiological parameters and adverse events were monitored throughout the intervention.Clinical scales,24-hour ambulatory blood pressure,blood tests,jugular ultrasound,and perfusion imaging were assessed preand post-intervention.Results No participants experienced intolerable discomfort or severe adverse events;vital signs remained within normal ranges.No significant changes were observed in 24-hour blood pressure,blood cell counts,lipid profiles,or other blood markers.Notably,60%of patients(n=12)reported overall symptom improvement on the Patient Global Impression of Change scale.Headache severity,as measured by the visual analogue scale,significantly decreased(6.33±1.22 vs.4.89±2.03,P=0.016).In patients with internal jugular vein(IJV)stenosis,significant improvements were observed in regional cerebral blood flow(including the insula,occipital lobe,internal capsule,and lenticula)and left J3-segment IJV flow volume(107.27[47.50,160.00]vs.140.83[55.00,210.00]mL/min,P=0.011).Conclusion The current IHHT protocol is safe and well-tolerated in patients with CVOD.IHHT may alleviate CVOD-related symptoms by improving oxygen saturation,cerebral perfusion,and venous outflow pattern,supporting its potential as a non-invasive therapeutic strategy. 展开更多
关键词 Cerebral vascular disease Intermittent hypoxia-hyperoxia training Cerebral venous outflow disorders Cerebral perfusion Acclimatization
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The potential and therapeutic advances of the integrin family in neurological disorders 认领 引用
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作者 Xingfang Zhang Liang Gao +7 位作者 Yiwen Wang Qian Meng Min Bai Dong Xu Yanhua Wang Jianv Wang Hongtao Bi Yi Ding 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期4177-4194,共18页
Neurological disorders encompass a diverse and heterogeneous group of medical conditions,including cerebrovascular diseases(e.g.,stroke),neurodegenerative diseases(e.g.,Alzheimer's disease and Parkinson's dise... Neurological disorders encompass a diverse and heterogeneous group of medical conditions,including cerebrovascular diseases(e.g.,stroke),neurodegenerative diseases(e.g.,Alzheimer's disease and Parkinson's disease),and autoimmune demyelinating disorders(e.g.,multiple sclerosis).With the global aging population,the incidence of these disorders continues to rise,posing significant challenges to healthcare systems and socio-economic structures.Recent studies have highlighted integrins—a family of transmembrane glycoprotein receptors—as critical regulators of central nervous system function,making them a focal point in neurological disease research.By interacting with the extracellular matrix,integrins modulate cell adhesion,signal transduction,and inflammatory responses,playing indispensable roles in neuronal development,synaptic plasticity,and blood-brain barrier maintenance.Dysregulated integrin signaling has been implicated in the pathophysiology of various neurological disorders,suggesting that integrin-targeting interventions,including integrin antagonists or agonists,could represent novel therapeutic strategies.Preclinical and clinical studies have demonstrated that modulating integrin function influences disease progression,offering promising avenues for the development of precision medicine approaches.This review provides a comprehensive analysis of integrin structure,classification,and their physiological and pathological roles in the central nervous system,with a focus on their molecular mechanisms in neurological disorders.Furthermore,we evaluate the therapeutic potential and challenges associated with integrintargeted interventions.By elucidating the mechanistic underpinnings of integrin function in the central nervous system,this review aims to advance our understanding of their translational potential,laying the groundwork for the development of innovative therapeutic strategies. 展开更多
关键词 Alzheimer’s disease blood-brain barrier central nervous system extracellular matrix hemorrhagic stroke integrin ischemic stroke multiple sclerosis neurological disorders Parkinson’s disease
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Pain-Affective Disorder Comorbidity in the Temporomandibular Disorders:From Mechanistic Insights to Clinical Management 认领 引用
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作者 Zhaoyichun Zhang Shibin Yu +3 位作者 Shengxi Wu Zuolin Jin Ze Fan Jing Huang 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第6期1401-1420,共20页
Temporomandibular disorders(TMDs)comprise a spectrum of conditions affecting the temporomandibular joint,masticatory musculature,dental occlusion,and even multiple systemic structures.Epidemiological data indicate tha... Temporomandibular disorders(TMDs)comprise a spectrum of conditions affecting the temporomandibular joint,masticatory musculature,dental occlusion,and even multiple systemic structures.Epidemiological data indicate that approximately 40%of patients with TMDs experience comorbid affective disorders,creating complex diagnostic and therapeutic challenges,further resulting in suboptimal management.This review summarizes the comorbidity spectrum of TMDs,especially focusing on the bidirectional relationship between TMD-related pain and affective disorders,with the aims of(1)elucidating shared neurobiological mechanisms involving central sensitization,maladaptive neuroplasticity,and neuro-endocrine-immune dysregulation in TMDs;(2)analyzing the role of psychosocial factors in perpetuating this comorbidity;and(3)evaluating evidence-based treatment strategies that address both somatic and psychological symptoms.This review concludes by highlighting emerging new technologies with the potential for improved risk assessment and advocates for personalized treatment paradigms in this complex patient population.Future research directions should prioritize longitudinal studies examining the trajectories of comorbidity as well as testing emerging intervention approaches. 展开更多
关键词 Temporomandibular disorders Chronic pain Affective disorder Comorbidity
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Unraveling the bidirectional association between mental disorders and prostatitis:insights from a genetic perspective 认领 引用
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作者 Guancan Liang Jian Pan +5 位作者 Ruixiang Dai Ziyi Lin Xunbao Wang Teng Hou Zhicheng Luo Xiaoming Wang 《The Canadian Journal of Urology》 SCIE 2026年第3期563-571,共9页
Background:The causal link betweenmental illness and prostatitis remains inconclusive,largely due to heterogeneity and potential confounders.This study explored the causal link between mental illness and prostatitis i... Background:The causal link betweenmental illness and prostatitis remains inconclusive,largely due to heterogeneity and potential confounders.This study explored the causal link between mental illness and prostatitis in men using Mendelian randomization(MR),and offered recommendations for enhancing future research.Methods:Publicly accessible genome-wide association study(GWAS)data were accessed via the IEU OpenGWAS platform and FinnGen database for this research.The inverse variance weighted(IVW)approach served as the primaryMendelian randomization analysis,while MR-Egger,weighted median,weighted mode,and simple mode methods were additionally applied to evaluate potential relationships between prostatitis and four psychiatric disorders(schizophrenia,depression,bipolar disorder,and anxiety).Results:The analysis indicated a signicant causal association between depression and prostatitis(OR=1766.294,p=0.01),whereas no evidence of a causal relationship was observed for schizophrenia,bipolar disorder,or anxiety with prostatitis(p>0.05).In the reverse-direction MR analysis,prostatitis showed no evidence of a causal effect on psychiatric disorders.Further sensitivity analyses did not reveal pleiotropy or heterogeneity,and leave-one-out analyses indicated that the overall results were not signicantly affected by any single instrumental variable.Sensitivity analyses provided no indication of pleiotropy or heterogeneity,and leave-one-out testing suggested that the overall results remained stable regardless of the exclusion of any single instrumental variable.Conclusion:The present study provides genetic evidence that depression may increase the risk of prostatitis,highlighting the need for early preventive strategies.Additional studies are needed to clarify the mechanisms connecting depression and prostatitis in men. 展开更多
关键词 Prostatitis mental disorders mendelian randomization genetics causal effect
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Systematic review and meta-analysis on vitamin C in musculoskeletal disorders 认领 引用
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作者 Madhan Jeyaraman Naveen Jeyaraman +5 位作者 Mainak Roy Arulkumar Nallakumarasamy Abdus Sami Sathish Muthu Karthikeyan P Iyengar Vijay Kumar Jain 《World Journal of Orthopedics》 2026年第5期142-153,共12页
BACKGROUND Chronic pain and musculoskeletal disorders(MSDs)are prevalent and impact health around the world.Traditional treatments may not always be effective and safe.AIM To determine the effectiveness of vitamin C s... BACKGROUND Chronic pain and musculoskeletal disorders(MSDs)are prevalent and impact health around the world.Traditional treatments may not always be effective and safe.AIM To determine the effectiveness of vitamin C supplementation on reducing pain,improving function and supporting tissue repair in MSDs.METHODS Randomized controlled trials,cohort studies,and observational studies that assessed the impact of vitamin C on MSDs.The Cochrane Risk of Bias tool was used to evaluate the quality of studies.Standardized mean differences(SMD)were pooled using random-effects meta-analysis.RESULTS Thirty studies were included in the meta-analysis.Vitamin C significantly reduced pain(SMD=-0.68;95%confidence interval:-0.87 to-0.49)and improved function(SMD=0.61;95%confidence interval:0.45-0.77).Collagen synthesis and inflammatory markers(C-reactive protein,interleukin-6 and tumor necrotizing factor-α)were all consistently improved.CONCLUSION Vitamin C supplementation might have additional benefits in some MSDs,such as reducing pain and inflammatory modulation.But there is currently little consistency in the evidence and medium quality of the methods used.No definitive therapeutic efficacy can be determined,and further well-designed,disorder-specific randomized controlled trials are required. 展开更多
关键词 Vitamin C Musculoskeletal disorders Analgesia Inflammation Tissue repair Antioxidants
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Science of heat mapping:Thermography in musculoskeletal disorders 认领 引用
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作者 Madhan Jeyaraman Naveen Jeyaraman +3 位作者 Arulkumar Nallakumarasamy Mainak Roy Tomas M de Souza Moraes Lucas F da Fonseca 《World Journal of Orthopedics》 2026年第1期29-39,共11页
Musculoskeletal injuries are among the most common causes of disability worldwide,with early detection and appropriate intervention critical to minimizing long-term complications.Infrared thermography(IRT)has emerged ... Musculoskeletal injuries are among the most common causes of disability worldwide,with early detection and appropriate intervention critical to minimizing long-term complications.Infrared thermography(IRT)has emerged as a noninvasive,real-time imaging modality that captures superficial temperature changes reflecting underlying physiological processes such as inflammation and vascular alterations.This review explores the fundamental principles of medical thermography,differentiates between passive and active approaches,and outlines key technological advancements including artificial intelligence integration.The clinical utility of IRT is discussed in various contexts–ranging from acute soft tissue injuries and overuse syndromes to chronic pain and rehabilitation monitoring.Comparative insights with conventional imaging techniques such as ultrasound and magnetic resonance imaging are also presented.While IRT offers functional imaging capabilities with advantages in portability,safety,and speed,its limitations–such as lack of deep-tissue penetration and protocol standardization–remain significant barriers to broader adoption.Future directions include the integration of IRT with other imaging modalities and digital health platforms to enhance musculoskeletal assessment and injury prevention strategies. 展开更多
关键词 Thermography Musculoskeletal injuries Heatmapping Infra-red imaging Musculoskeletal disorders
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Association of depression,anxiety,and insomnia in hypertensive disorders in pregnant women 认领 引用
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作者 Jun Huang Yan-Jun Yang +2 位作者 Yan Lv Xian Xu Chang-Fang Yao 《World Journal of Psychiatry》 SCIE 2026年第2期109-116,共8页
BACKGROUND Insomnia in patients with hypertensive disorders in pregnancy(HDP)appears closely associated with depression and anxiety,though this relationship requires further validation.AIM To examine the inter-relatio... BACKGROUND Insomnia in patients with hypertensive disorders in pregnancy(HDP)appears closely associated with depression and anxiety,though this relationship requires further validation.AIM To examine the inter-relationships among depression,anxiety,and insomnia in women with HDP.METHODS A total of 122 HDP cases were enrolled from January 2021 to January 2025.The Patient Health Questionnaire-9(PHQ-9)was used to evaluate depressive symptoms,while the Generalized Anxiety Disorder-7(GAD-7)assessed anxiety.Sleep duration,sleep efficiency,and insomnia were measured using the Pittsburgh Sleep Quality Index(PSQI).Spearman’s r determined inter-scale correlations.Deter-minants influencing depression and anxiety were identified via univariate and multivariate analyses.RESULTS Among the 122 women with HDP,20.49%exhibited depression and 24.59%had anxiety.The mean PHQ-9 and GAD-7 scores were 4.00(3.00,4.00)and 4.00(3.00,4.25),res-pectively.As pregnancy progressed,participants showed reduced sleep duration and efficiency,higher PSQI total scores,and an increased proportion of poor sleepers.Across all gestational stages,PHQ-9 and GAD-7 scores were positively correlated with PSQI results.Depression and anxiety were independently associated with a prior HDP history,limited spousal support,PSQI>5,and monthly income5,or monthly income<4000 yuan. 展开更多
关键词 Hypertensive disorders in pregnancy Pregnant women Depression Anxiety Insomnia
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Liquid biopsies in psychiatric disorders:Identifying peripheral biomarkers of brain health 认领 引用
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作者 Jennifer L.Payne Sarven Sabunciyan 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期691-692,共2页
The inability to access brain tissue has greatly hindered our ability to study and care for individuals suffering from psychiatric and neurological conditions.Critics have questioned efforts to develop peripheral bloo... The inability to access brain tissue has greatly hindered our ability to study and care for individuals suffering from psychiatric and neurological conditions.Critics have questioned efforts to develop peripheral blood biomarkers in neurological and psychiatric disorders based on the assertion that disease pathology is limited to the brain.The discovery that all tissues,including the brain,release extracellular vesicles(Raposo and Stoorvogel,2013)and cell free DNAs(Chan et al.,2013)into various body fluids has provided a potential way to measure activity from inaccessible tissues like the central nervous system(CNS)and has given rise to the term“liquid biopsy.”The development of liquid biopsies that can diagnose and predict the course of psychiatric and neurological disorders would be transformative.The ability to predict episodic events such as mania,depression,and risk for suicide would be particularly useful for psychiatric care as it would enable the development of interventions that prevent mortality and improve outcomes.Additionally,biomarkers that are informative about drug response and aid in treatment decisions would be a significant advance in psychiatric care as it would prevent patients from having to endure multiple courses of ineffective treatments and side effects. 展开更多
关键词 develop peripheral blood biomarkers liquid biopsies study care individuals cell free dnas chan extracellular vesicles raposo body fluids neurological psychiatric disorders peripheral biomarkers
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Nanoparticle-assisted gene editing for genomic disorders in the central nervous system 认领 引用
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作者 Hyeon-Yeol Cho Jeong-Woo Choi 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3547-3548,共2页
Genomic disorders affecting the central nervous system(CNS)are among the most complex and devastating conditions in human health.Moreover,these disorders,such as Rett syndrome,spinal muscular atrophy,and Fragile X syn... Genomic disorders affecting the central nervous system(CNS)are among the most complex and devastating conditions in human health.Moreover,these disorders,such as Rett syndrome,spinal muscular atrophy,and Fragile X syndrome,are typically caused by mutations in genes essential for neural development,synaptic function,or cellular homeostasis.Despite the genetic diversity involved,these diseases share key pathological features,including progressive neurodegeneration,disruption of neural circuits,and loss of cognitive or motor function.Meanwhile,one of the significant clinical challenges in treating CNS disorders is the limited regenerative capacity of the adult nervous system,which makes reversing disease progression extremely difficult once symptoms appear.In addition,the blood-brain barrier(BBB)restricts the passage of most systemically administered therapeutics,further complicating effective intervention.Consequently,current treatment options remain largely palliative,and effective cures remain elusive. 展开更多
关键词 nanoparticle assisted gene editing central nervous system genomic disorders fragile x syndromeare central nervous system cns rett syndromespinal muscular atrophyand progressive neurodegenerationdisruption neural circuitsand loss cogni
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Anxiety and depression in Rome IV disorders of gut–brain interaction:Prevalence,clinical impact,and temporal association 认领 引用
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作者 Manjeet Kumar Goyal Omesh Goyal +4 位作者 Praneet Wander Jaskirat Kaur Gargi Prashar Prerna Goyal Ajit Sood 《World Journal of Psychiatry》 SCIE 2026年第8期377-390,共14页
BACKGROUND Patients with disorders of gut-brain interaction(DGBIs)frequently report coexisting anxiety and depression;yet data on the prevalence,clinical impact and temporal association of psychological comorbidities ... BACKGROUND Patients with disorders of gut-brain interaction(DGBIs)frequently report coexisting anxiety and depression;yet data on the prevalence,clinical impact and temporal association of psychological comorbidities across the full spectrum of DGBIs,particularly regarding overlap syndromes,remain limited.AIM To evaluate the prevalence and temporal relationship of anxiety and depression among DGBIs,and assess the impact of overlapping DGBIs.METHODS In this prospective cross-sectional study conducted at a tertiary care centre in northern India,adults fulfilling Rome IV criteria for DGBIs were enrolled and compared with age-and sex-matched controls.Anxiety and depression were assessed using validated Generalized Anxiety Disorder 7-item and Patient Health Questionnaire 9-item depression scales,and health-related quality-of-life using the Patient-Reported Outcomes Measurement Information Systems(PROMIS)global questionnaire.RESULTS Among 1044 patients with DGBIs,anxiety and depression were present in 64.2%and 37.8%,respectively;being significantly higher in patients with overlapping DGBIs compared with single DGBI(81.2%vs 52.8%;and 51.3%vs 28.7%,respectively;both P<0.0001).Health-related quality-of-life was significantly worse among DGBI patients,particularly those with overlap syndromes.In temporal analyses,gastrointestinal symptoms preceded the onset of anxiety in 71.0%and depression in 78.5%patients(P<0.0001),with DGBI overlap being the strongest predictor of anxiety and depression.CONCLUSION DGBIs are associated with a substantial psychological burden,especially in patients with overlapping syndromes.Gastrointestinal symptom onset commonly antedates psychological distress,supporting a clinically relevant‘gutfirst’trajectory.Early recognition and effective management of DGBIs may therefore play a role in mitigating subsequent psychological morbidity,underscoring the need for integrated management. 展开更多
关键词 Anxiety Depression Functional bowel disorders Functional constipation Functional dyspepsia Irritable bowel syndrome Overlap Quality of life Rome IV criteria
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Genetic elastic fiber disorders as neurovascular syndromes:An emerging perspective 认领 引用
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作者 Francesc Jiménez-Altayó 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期4261-4262,共2页
Genetic elastic fiber diseases arise from inherited or de novo mutations in genes encoding elastic fiber components,such as elastin,fibrillin-1,and associated proteins,leading to abnormalities in their deposition,stru... Genetic elastic fiber diseases arise from inherited or de novo mutations in genes encoding elastic fiber components,such as elastin,fibrillin-1,and associated proteins,leading to abnormalities in their deposition,structure,or degradation(Heinz,2021).Histo rically,research has focused on systemic,non-neurological manifestations,which are more clinically apparent and often life-threatening,particularly cardiovascular complications.In contrast,potential involvement of the central nervous system(CNS) has received limited attention,even though the brain and spinal cord are richly vascula rized structu res,extensively perfused,and critically dependent on the integrity of their blood vessels. 展开更多
关键词 elastic fiber componentssuch genetic elastic fiber diseases central nervous system elastin genetic elastic fiber disorders vasculature fibrillin central nervous system cns
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Beyond assumptions:Revisiting the link between consanguinity and pediatric neurodevelopmental disorders 认领 引用
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作者 Mohammed Al-Beltagi 《World Journal of Translational Medicine》 2026年第2期1-6,共6页
Parental consanguinity is associated with an increased risk of autosomal recessive disorders,some of which may present neurological and developmental impairment.In this issue,a retrospective cohort study from Jazan,Sa... Parental consanguinity is associated with an increased risk of autosomal recessive disorders,some of which may present neurological and developmental impairment.In this issue,a retrospective cohort study from Jazan,Saudi Arabia,by Alhamoud et al,published in the World Journal of Clinical Pediatrics”,evaluated the relationship between consanguinity and neurodevelopmental outcomes in pediatric patients and found no statistically significant association despite minor differences in clinical patterns.This finding highlights the challenges of detecting genetic effects within heterogeneous clinical populations,particularly when neurodevelopmental conditions include both monogenic and multifactorial etiologies.This editorial contextualizes these results within current genetic and epidemiological understanding,emphasizing that cohort-level findings may not fully capture underlying biological risk.It also outlines key clinical and public health considerations,including targeted developmental screening and culturally appropriate genetic counseling,and underscores the need for well-designed prospective studies incorporating genomic data and precise phenotyping. 展开更多
关键词 Consanguinity Neurodevelopmental disorders Epilepsy Genetic counseling Autosomal recessive diseases Pediatric neurology Gene-environment interaction Saudi Arabia Middle East
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Intersection of mitochondrial dysfunction and myelination:An overlooked aspect in neurodevelopmental disorders 认领 引用 被引量：1
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作者 Ariel Nir Sade Gal Wiener Boaz Barak 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期659-660,共2页
Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th... Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs. 展开更多
关键词 neurodevelopmental disorders ndds rokach white matter developing brain myelination neurodevelopmental processes mitochondrial dysfunction white matter wm known developing braina
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