It is estimated that at least two million women of childbearing age in Latin America are chronically infected with Trypanosoma(T.)cruzi,representing a persistent risk of congenital transmission[1].Vertical transmissio...It is estimated that at least two million women of childbearing age in Latin America are chronically infected with Trypanosoma(T.)cruzi,representing a persistent risk of congenital transmission[1].Vertical transmission has been associated with maternal immune dysfunction,which may compromise foetal development and increase the risk of adverse outcomes[2].According to the Brazilian consensus on Chagas disease(CD),breastfeeding represents a potential route of transmission when the parasite is present in milk,especially during the acute phase or in cases of nipple lesions with bleeding[3,4].However,experimental evidence in lactating females during the acute phase is scarce,and reports of transmission via breastfeeding remain inconclusive.展开更多
基金supported by a specialization grant from the SUS/SP Human Resources Training Center,CEFORSUS/SP.
摘要It is estimated that at least two million women of childbearing age in Latin America are chronically infected with Trypanosoma(T.)cruzi,representing a persistent risk of congenital transmission[1].Vertical transmission has been associated with maternal immune dysfunction,which may compromise foetal development and increase the risk of adverse outcomes[2].According to the Brazilian consensus on Chagas disease(CD),breastfeeding represents a potential route of transmission when the parasite is present in milk,especially during the acute phase or in cases of nipple lesions with bleeding[3,4].However,experimental evidence in lactating females during the acute phase is scarce,and reports of transmission via breastfeeding remain inconclusive.