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Impact of government-organized screening programs on the economic burden of cervical cancer across five disease courses:a multistage regression and mediation analysis 认领 引用
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作者 Mingjie Dong Jiaxin Xie +1 位作者 Xuelian Zhao Fanghui Zhao 《Cancer Biology & Medicine》 SCIE CAS CSCD 2025年第9期1083-1101,共19页
Objective:To evaluate the impact of government-organized screening on the economic burden among patients with cervical cancer and precancerous lesions,and explore mediating pathways across diagnosis,initial treatment,... Objective:To evaluate the impact of government-organized screening on the economic burden among patients with cervical cancer and precancerous lesions,and explore mediating pathways across diagnosis,initial treatment,radiotherapy/chemotherapy,follow-up,and recurrence/progression/metastasis.Methods:A multicentre,nationwide survey across 5 disease courses was conducted from 26 hospitals in China.Multivariable regression and structural equation modeling were used to assess the effects of government-organized screening on economic burden by comparing government-organized screening with workplace check-up,self-paid check-up,and symptom-based detection.Results:Workplace check-up,self-paid check-up,and symptom-based detection were associated with progressively higher costs across diagnosis[β:1.10,95%confidence interval(CI):0.54±1.67;β:1.46,95%CI:1.00±1.92;andβ:1.68,95%CI:1.25±2.11,respectively],initial treatment(β:0.36,95%CI:0.18±0.55;β:0.51,95%CI:0.35±0.66;andβ:0.56,95%CI:0.42±0.70,respectively),and follow-up(β:0.63,95%CI:0.38±0.88;β:0.83,95%CI:0.61±1.04;andβ:0.85,95%CI:0.65±1.06,respectively)compared to government-organized screening(all P<0.05).Earlier clinical staging and greater use of lower-level hospitals mediated 44.74%±54.97%of cost differences in diagnosis,73.27%±85.04%in initial treatment,and 30.38%±54.73%in follow-up.Fifteen percent of the cost differences during initial treatment were related to lower overtreatment for precancerous lesions.Conclusions:Government-led cervical cancer screening was associated with lower economic burden with pathways involving earlier-stage diagnosis,reduced overtreatment,and decreased reliance on higher-level hospitals,suggesting potential clinical benefits,efficient resource use,and improved equity in cancer care. 展开更多
关键词 Cervical cancer government-organized screening economic burden early detection
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Beyond distance:integrating economic burden into large-scale primary healthcare accessibility analysis 认领 引用 被引量：2
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作者 Bin Zhu Liutong Chen +5 位作者 Yifei He Ning Zhang Hao Xue Samir Bhatt Minghui Ren Ying Mao 《Global Health Research and Policy》 CSCD 2025年第1期154-169,共16页
Background Access to primary healthcare(PHC)services is a critical determinant of population health outcomes and a key indicator of health system performance.However,comprehensive methods for batch assessment of PHC a... Background Access to primary healthcare(PHC)services is a critical determinant of population health outcomes and a key indicator of health system performance.However,comprehensive methods for batch assessment of PHC accessibility and the associated economic burden are relatively scarce.This gap is particularly evident in developing countries,where accessibility challenges are often more pronounced.Methods We developed an integrated assessment methodology for the large-scale calculation of travel costs to access PHC services.This methodology combines high-resolution friction surface mapping,the construction of a comprehensive PHC facility spatial dataset,and the application of least-cost path algorithms.The batch processing capability of the methodology ensures efficient computation while maintaining high spatial resolution,enabling a detailed evaluation of PHC accessibility and its economic burden across diverse geographical contexts.Results Our analysis revealed that 88.70%of Chinese mainland's population could access PHC facilities within an hour,indicating relatively good overall accessibility to primary healthcare services.However,significant regional disparities in accessibility and associated economic burdens were observed.While urban areas,particularly in eastern and coastal regions,generally exhibit high levels of accessibility,rural and remote areas,especially in the western and northwestern regions,face substantial challenges in reaching PHC facilities.The total economic burden associated with travel to PHC facilities in Chinese mainland is estimated at approximately 38.29 billion CNY annually.The southern,northern,and northwestern regions accounted for 62.91%,21.72%,and 14.94%of the total burden respectively,with northwestern provinces facing a disproportionately high economic burden relative to their GDP.Conclusions Our methodology supports future large-scale,high-resolution accessibility analyses that can guide interventions aimed at addressing healthcare disparities and improving equity.The empirical application of this methodology in Chinese mainland revealed significant disparities in PHC access across the country and quantified the substantial economic costs associated with these disparities. 展开更多
关键词 Primary healthcare PHC accessibility Travel costs Economic burden Geospatial analysis Chinese mainland
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Health-related quality of life and economic burden of hospitalized children with meningitis in China:A multiregional study 认领 引用
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作者 Hongfei Hu Ting Zhou +6 位作者 Junyang Gao Huijun Zhou Hongjie Yu Shiying Li Mark Jit Pei Wang Jing Li 《Pharmacoeconomics and Policy》 2025年第4期182-189,共8页
Meningitis is a serious disease and it brings challenges to the health system worldwide.The aim was to estimate the health-related quality of life(HRQOL)and economic burden of children with meningitis in China and to ... Meningitis is a serious disease and it brings challenges to the health system worldwide.The aim was to estimate the health-related quality of life(HRQOL)and economic burden of children with meningitis in China and to explore the associated factors.A longitudinal cohort study was conducted to track HRQOL measured with a proxy version of the proxy youth version of the 5-level EuroQol-five dimensions questionnaire(EQ-5D-Y)in children under six years of age before and after receiving medical treatment for meningitis,and to collect data on both direct and indirect costs associated with the disease in multiregions.A total of 323 subjects were included in the study.The mean EQ-5D-Y utility value was 0.701(standard deviation(SD)0.202)(EQ visual analogue scale(EQ-VAS)score:55.5(17.5))at baseline,with the most reported problems occurring in two dimensions:having pain or discomfort(94.4%)and feeling worried,sad,or unhappy(89.8%).At discharge,the mean utility value increased to 0.926(0.104)(EQ-VAS score:89.8(10.3)).The average total cost and hospitalization cost was 12,260 Chinese Yuan(CNY)and 7723 CNY,respectively.Region and loss of the work time were the main factors both had impact on utility value and total cost in regression analyses.These findings indicate substantial regional variation in HRQOL outcomes and highlight the heavy economic burden meningitis imposes on affected families and society. 展开更多
关键词 Meningitis Pediatrics Health-related quality of life Health utility Economic burden of disease
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Estimation of economic burden throughout course of cervical squamous intraepithelial lesion and cervical cancer in China:A nationwide multicenter cross-sectional study 认领 引用 被引量：13
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作者 Hao Chen Xuelian Zhao +6 位作者 Shangying Hu Tingting You Changfa Xia Meng Gao Mingjie Dong Youlin Qiao Fanghui Zhao 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2023年第6期675-685,共11页
Objective: Cervical squamous intraepithelial lesion(SIL) and cervical cancer are major threats to females' health and life in China, and we aimed to estimate the economic burden associated with their diagnosis and... Objective: Cervical squamous intraepithelial lesion(SIL) and cervical cancer are major threats to females' health and life in China, and we aimed to estimate the economic burden associated with their diagnosis and treatment.Methods: A nationwide multicenter, cross-sectional, hospital-based survey was conducted in 26 qualified hospitals across seven administrative regions of China. We investigated females who had been pathologically diagnosed with SIL and cervical cancer, and included five disease courses(“diagnosis”, “initial treatment”,“chemoradiotherapy”, “follow-up” and “recurrence/progression/metastasis”) to estimate the total costs. The median and interquartile range(IQR) of total costs(including direct medical, direct non-medical, and indirect costs), reimbursement rate by medical insurance, and catastrophic health expenditures in every clinical stage were calculated.Results: A total of 3,471 patients in different clinical stages were analyzed, including low-grade SIL(LSIL)(n=549), high-grade SIL(HSIL)(n=803), cervical cancer stage ⅠA(n=226), ⅠB(n=610), ⅡA(n=487), ⅡB(n=282), Ⅲ(n=452) and Ⅳ(n=62). In urban areas, the estimated total costs of LSIL and HSIL were $1,637.7(IQR:$956.4-$2,669.2) and $2,467.1(IQR:$1,579.1-$3,762.3), while in rural areas the costs were $459.0(IQR:$167.7-$1,330.3) and $1,230.5(IQR:$560.6-$2,104.5), respectively. For patients with cervical cancer stage ⅠA,ⅠB, ⅡA, ⅡB, and Ⅲ-Ⅳ, the total costs were $15,034.9(IQR:$11,083.4-$21,632.4), $19,438.6(IQR:$14,060.0-$26,505.9), $22,968.8(IQR:$16,068.8-$34,615.9), $26,936.0(IQR:$18,176.6-$41,386.0) and $27,332.6(IQR:$17,538.7-$44,897.0), respectively. Medical insurance covered 43%-55% of direct medical costs for cervical cancer patients, while the coverage for SIL patients was 19%-43%. For most cervical cancer patients, the expense was catastrophic, and the extent of catastrophic health expenditure was about twice large for rural patients than that for urban patients in each stage.Conclusions: The economic burden of SIL and cervical cancer in China is substantial, with a significant proportion of the costs being avoidable for patients with LSIL. Even for those with medical insurance, catastrophic health expenditures are also a major concern for patients with cervical cancer, particularly for those living in rural areas. 展开更多
关键词 Squamous intraepithelial lesion cervical cancer economic burden medicare catastrophic health expenditures
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Medical service utilisation, economic burden and health status of patients with rare diseases in China 认领 引用 被引量：4
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作者 Mengyuan Fu Xiaodong Guan +2 位作者 Guoxu Wei Xiaoxiong Xin Luwen Shi 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2018年第5期361-369,共9页
Many patients with rare diseases not only suffer from more severe conditions but often receive less disease management, which is one significant public health concern globally. Few practice-based surveys focus on the ... Many patients with rare diseases not only suffer from more severe conditions but often receive less disease management, which is one significant public health concern globally. Few practice-based surveys focus on the care of patients with rare diseases. In the present study, we aimed to investigate medical service utilization, economic burden and health status of patients with rare diseases in China. A cross-sectional questionnaire survey focusing on patients with rare diseases was conducted. Descriptive analysis was conducted to examine the sociodemographic characteristics, medical service utilization, economic burden and health status. Logistic regression analysis was applied to explore influencing factors of self-rated health. A total of 982 patients with 81 types of diseases were included in this survey. We found that 58.2% of patients experienced misdiagnosis, and 35.2% of the patients were misdiagnosed for at least five times. Moreover, 65.8% of patients traveled to hospitals to seek medical services, and 92.1% of patients paid expenses for their treatment. However, only 1.3% of patients could afford their medical expenditure without debts, and 86.8% of patients regarded their health status as bad or moderate. Significant factors correlated with health status were economic status, gender, age, employment and household size. From this study, the accessibility of medical service utilization, the affordability of medical economic burden, and the condition of health status for patients with rare disease in China were considerably poor. Basic medical insurance did not play its role in improving the utilization of medical services and the affordability of medical costs. Social support should be encouraged to improve patients＇ health status. 展开更多
关键词 Medical service utilization Economic burden Health status Rare diseases
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Economic burden and influencing factor analysis of outpatients with epilepsy: A cross-sectional study in Shanghai,Shanxi and Sichuan 认领 引用 被引量：2
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作者 Bing-Yu Wang Yang-Mu Huang +1 位作者 Shi-Chuo Li Yan Guo 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2018年第1期82-88,共7页
Objective: To better understand the economic burden of patients with epilepsy receiving outpatient services in China and to analyze potential factors influencing epileptic economic burden through a cross-sectional stu... Objective: To better understand the economic burden of patients with epilepsy receiving outpatient services in China and to analyze potential factors influencing epileptic economic burden through a cross-sectional study. Methods: Using a self-designed questionnaire, we collected information retrospectively from 754 patients with epilepsy evaluated in neurology clinics in Shanghai Municipality, Shanxi Province and Sichuan Province. Descriptive analyses were used after cost variables were presented as logarithms, and multiple linear regressions were performed to explore influencing factors. Results: Fifty percent of the investigated patients experienced an epilepsy attack before the age of 15, and 51.3% had suffered from epilepsy for more than five years. In the past year, 87.9% of patients had visited different hospitals multiple times for evaluation(40.3%) and maintenance treatment(40.7%). The total economic burden of epilepsy was US$ 1143.2. The average direct economic burden and indirect economic burden were US$ 939.0 and US$ 110.2, respectively. Multiple linear regressions showed that patients had to bear greater economic burden if they were hospitalized,using multiple antiepileptic drugs, experiencing illness for less than 5 years, in severe seizure index or active epilepsy with drug resistance, which was statistically significant. Totally only14.3% of patients could get reimbursement in outpatient services. Conclusions: Patients with epilepsy must present to hospitals regularly for satisfactory prognosis, which results in economic burden. Patients bear greater economic burden, especially direct medical costs, if they are newly diagnosed, experience severe seizures, or undergo multiple drug treatments that require more frequent monitoring. However, current insurance policy for outpatient services do not help reduce economic burden of patients efficiently. 展开更多
关键词 Epilepsy Outpatients Economic Burden Influencing Factors Insurance China
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Healthcare utilization patterns and economic burden of animal bites:A cross-sectional study 认领 引用 被引量：2
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作者 Vahid Bay Aziz Rezapour +2 位作者 Mehdi Jafari Mohammad Reza Maleki Irvan Masoudi Asl 《Journal of Acute Disease》 2021年第4期142-146,共5页
Objective:To determine the healthcare utilization patterns and estimate the economic burden of animal bites in Golestan province,north part of Iran.Methods:This cross-sectional study was performed based on the data of... Objective:To determine the healthcare utilization patterns and estimate the economic burden of animal bites in Golestan province,north part of Iran.Methods:This cross-sectional study was performed based on the data of 12181 animal-bite patients from Golestan province who were referred to the rabies prophylaxis centers between March 2019 and March 2020.The study was a societal perspective,and all patients were investigated by census method.The micro-costing method with a bottom-up approach as well as the human capital approach were used to estimate the economic burden.Results:In our study,the economic burden caused by animal bites was estimated at$1383639(275354672060 Rials).The largest share of costs was related to direct healthcare costs,direct non-healthcare costs,and indirect costs accouting for 91%,5%,and 4%,respectively.In addition,the average cost of a animal-bite patient was estimated at$113.5(22605260 Rials)(The average cost of a case in type 2 and 3 exposures was$45 and$412.8,respectively).The largest share of direct healthcare costs was related to immunoglobulin,vaccine,and personnel expenses accounting for 61.3%,19.8%,and 11.65%,respectively.Conclusions:Our study shows that animal bites in Golestan province,north of Iran impose a high economic burden on the communities,especially the healthcare system,which indicates the need to review management and control programs of animal bites and rabies based on animal-bite patterns of the area. 展开更多
关键词 Animal bites Rabies Economic burden
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Medical Resource Utilizations and Economic Burden in Chinese Cancer Patients with Chemotherapy-induced Anemia:A Populational Database Study 认领 引用
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作者 刘介宇 刘沧梧 +2 位作者 刘季鑫 萧金福 陈立宗 《Chinese Journal of Cancer Research》 SCIE CAS 2008年第4期307-315,共9页
Objective： Most of published studies emphasized the medical cost of treating chemotherapy-induced anemia （CIA） by using specific agents, for example, epoetin α, epoetin β, darbepoetin α or combined with red bloo... Objective： Most of published studies emphasized the medical cost of treating chemotherapy-induced anemia （CIA） by using specific agents, for example, epoetin α, epoetin β, darbepoetin α or combined with red blood cell transfusions, however, the investigation of the overall medical resources utilizations and economic burden of CIA is still limited. Besides, such studies which emphasized Chinese population still lack. The aim of this study is to investigate the medical resource utilization and the economic burden of Chinese cancer patients with CIA by using a populational representative claim database. Methods： The data for this study are from the 2000-2003 Population Health Insurance Research Database （PHIRD） in Taiwan. On the basis of issuing catastrophic illness cards in the enrollment data files, a total of 26,053 beneficiaries were identified from the PHIRD, who were newly diagnosed with these four cancers in 2001 and 2002 （2001： n=12,954; 2002： n=13099）. A generalized linear model （GLM） was employed for analyzing the differences of medical resource utilization and economic burden between the anemic and non-anemic groups. Results： Analyses showed that the anemic patients were significantly more likely to have longer length of hospital stay than non-anemic patients （P〈0.05） across all these four cancers and in two study periods （except women breast cancer in 2002/03）. As regards the health care expenditures, the average one-year total medical cost was USD$8,982 （2001/02） and USD$8,990 （2002/03） for anemic patients among these four cancers, and USD$7,769 （2001/02） and USD$7713 （2002/03） for non-anemic patients （P〈0.0001）. As for ambulatory costs, anemic patients＇ was significantly higher than non-anemic patients＇ for lung cancer （in 2001/02）, women breast cancer （in 2001/02 and 2002103） and the summarized data （in 2001/02）. As for inpatient costs, anemic patients＇ was significantly higher than non-anemic patients＇ for gastric cancer （in 2002/03）, colon and rectal cancer （in 2001/02 and 2002/03）, lung cancer （in 2001/02 and 2002/03）, women breast cancer （in 2001/02） and the summarized data （in 2001/02 and 2002/03）. Conclusion： This study is the first study to demonstrate that cancer patients who receive chemotherapy and with anemia utilize more medical resources and have heavier economic burden among Chinese cancer patients. Although the Population Health Insurance Program in Taiwan was established to provide more low-burdened medical care for all cancer patients, further effort is still needed to reduce the economic burden for cancer patients who have specific complications. 展开更多
关键词 Economic burden Medical cost Cancer Chemotherapy Anemia
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Economic Burden of Illness of the Cervical Cancer Treatment Protocol in Bangladesh 认领 引用
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作者 Shamima Aktar Md. Shawkat Ali 《Journal of Cancer Therapy》 2024年第10期346-361,共16页
Background: Cervical cancer is a significant health concern in Bangladesh, with high mortality rates due to limited awareness and costly treatments. The disease stages influence treatment protocols, ranging from surge... Background: Cervical cancer is a significant health concern in Bangladesh, with high mortality rates due to limited awareness and costly treatments. The disease stages influence treatment protocols, ranging from surgery and radiotherapy for early stages to chemotherapy and radiation for advanced stages, but survival rates decrease as the cancer progresses. Objective: The objective of this study is to determine the economic impact of the disease and recommend cost-efficient strategies for prevention and treatment. Methods: A population-based, cross-sectional study was conducted with a stratified sample of cervical cancer patients from selected healthcare facilities across Bangladesh. Data collection involved structured interviews and validated questionnaires. The study measured the economic impact, treatment costs, and other related expenses. Quantitative data analysis was performed using SPSS v22, MS-Excel, and R Programming, with Multivariate regression analysis and Post Hoc tests, including the chi-square test, applied to selected indicators. Results: All respondents in the study were female, aged 34 - 75, with 72.3% aged 40 - 50. Most were illiterate (38.6%) and housewives (95.0%). Additionally, 98% were married, 85.10% married before age 18, and 46.50% experienced their first menstruation before age 12. Families typically had a monthly income of 10,000 - 30,000 Taka, spending similar amounts on treatment. Significant relationships were found between educational qualifications, occupation, personal hygiene practices, history of oral contraceptive use, and age of marriage (p Conclusion: The article emphasizes the impact of monthly family income on cervical cancer treatment costs, stressing the need for comprehensive support services to address the financial and emotional burdens faced by patients. Improving access to quality care and implementing measures can enhance outcomes for cervical cancer patients in Bangladesh. 展开更多
关键词 Economic Burden Cervical Cancer Monthly Family Income Treatment Cost Related Others Cost
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Projected Prevalence and Economic Burden of Alzheimer’s Disease and Related Dementias in China:Regional Disparities and Policy Implications 认领 引用
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作者 Xinyi Liu Simiao Chen +6 位作者 Donglan Zhang Yian Gu Gang Li Bei Wu José A.Pagán Luxia Zhang Yan Li 《Health Data Science》 CSCD 2025年第1期6-17,共12页
Background:China has the largest population with Alzheimer’s disease and related dementias(ADRDs)globally,and rapid population aging is expected to drive a substantial increase in cases.This study projects ADRD preva... Background:China has the largest population with Alzheimer’s disease and related dementias(ADRDs)globally,and rapid population aging is expected to drive a substantial increase in cases.This study projects ADRD prevalence and associated economic burdens across provinces in China from 2025 to 2060.Methods:Using data from the China Health and Retirement Longitudinal Study(CHARLS)supplemented by national demographic and provincial statistics,we projected the prevalence and care costs of ADRD for each of the 31 provinces in China from 2025 to 2060.Cost projections included formal care expenses and informal caregiving valued through replacement cost methods.We conducted uncertainty analysis to provide robust estimates for ADRD prevalence and costs.Results:By 2060,ADRD cases in China are projected to reach approximately 49.89 million,with the highest prevalence and economic burden concentrated in provinces such as Shandong,Sichuan,Jiangsu,Henan,and Guangdong.Formal care costs alone are expected to exceed$1 trillion annually,while the total economic value—including informal caregiving—could surpass$5 trillion.Geographic disparities highlight that Eastern and Central regions,with a higher proportions of older adults,will bear disproportionate costs.Informal caregiving is projected to constitute 60% to 80% of total ADRD-related costs.Conclusion:China faces an unprecedented rise in ADRD-related economic burden over the next 4 decades,with substantial regional disparities.Strengthening long-term care infrastructure,expanding financial and social support for caregivers,and implementing regionally tailored healthy aging policies are essential to ensuring equitable and sustainable ADRD care across China. 展开更多
关键词 regional disparities alzheimer s disease related dementias adrds globallyand prevalence national demographic provincial statisticswe policy implications economic burden population aging Alzheimers disease
Estimation and prediction on the economic burden of schistosomiasis in 25 endemic countries 认领 引用
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作者 Xian-Fa Chen Qin Li +8 位作者 Robert Bergquist Jin-Xin Zheng Su-Ying Guo Qiu-Feng Lan Zheng-Ze He Li-Juan Zhang Chun-Li Cao Jing Xu Xiao-Nong Zhou 《Infectious Diseases of Poverty》 SCIE CSCD 2025年第3期32-45,共14页
Background Schistosomiasis is a neglected tropical disease,primarily prevalent in tropical and subtropical regions.It imposes a significant health and economic burden in low-and middle-income countries,but a study of ... Background Schistosomiasis is a neglected tropical disease,primarily prevalent in tropical and subtropical regions.It imposes a significant health and economic burden in low-and middle-income countries,but a study of its comprehensive economic impact of the disease at the global level has not been carried out.As this is essential for evidence-based decision-making,this study aims to estimate the macroeconomic burden of schistosomiasis in 25 endemic countries.Methods We used a health-augmented macroeconomic(HAM)model,as well as observed data from 2010 to 2021 and projected data from 2022 to 2050,to model gross domestic product(GDP)under two scenarios:with and without schistosomiasis.The data were obtained from the Global Burden of Disease Study 2021(GBD 2021),the World Bank database,the International Monetary Fund(IMF)database,the International Labour Organization(ILO)database,the United Nations Population Division’s World Population Prospects 2022 database,the Barro-Lee Educational Attainment dataset,the Penn World Table(PWT)database,and relevant literature.The economic burden was quantified as the difference in GDP between these two scenarios.The HAM model considered:(i)the impact of schistosomiasis mortality and morbidity on labor supply;(ii)age and gender differences in education and work experience among schistosomiasis patients;and(iii)the impact of schistosomiasis treatment costs on physical capital accumulation.To be able to compare the purchasing power of different countries,we used international dollars(INT$),a hypothetical currency unit based on purchasing power parity.Results We estimated the macroeconomic burden of schistosomiasis in 25 schistosomiasis endemic countries was INT$49,504 million[uncertainty interval(UI):48,668–50,339]for the study period,using a 3%discount rate in the main analysis.The result implies that the economic burden of schistosomiasis across these 25 countries during study period is equivalent to 0.0174%(UI:0.0171–0.0177)of total GDP.Among all schistosomiasis-endemic countries included,Egypt had the largest absolute economic burden(INT$11,400 million,UI:11,221–11,578),followed by Brazil(INT$9779 million,UI:9717–9841)and South Africa(INT$6744 million,UI:6676–6811).Conclusions The global economic burden of schistosomiasis remains substantial and is inequitably distributed among countries and regions.Our study highlights the need for increased investment and global collaborative efforts to control schistosomiasis and its associated health and economic burdens.By advancing the elimination of schistosomiasis,substantial economic returns can be achieved. 展开更多
关键词 Schistosomiasis Elimination Economic burden Global burden Macroeconomic model Endemic country
Economic burden of inpatients with viral hepatitis B-related diseases and the influencing factors 认领 引用 被引量：2
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作者 Hua Zhang Jianqian Chao +3 位作者 Liguo Zhu Long Song Xiyan Li Pei Liu 《Family Medicine and Community Health》 2013年第4期31-35,共5页
Objective:The purpose of this study was to analyze the economic burden of inpatients with hepatitis B virus(HBV)-related diseases and the influencing factors so as to provide an effective basis for the development of ... Objective:The purpose of this study was to analyze the economic burden of inpatients with hepatitis B virus(HBV)-related diseases and the influencing factors so as to provide an effective basis for the development of health prevention and control strategies.Methods:The patients were selected by means of successive sampling in the period between August and December 2012 from those who were diagnosed with HBV-related diseases and hospitalized in countylevel medical institutions of Jiangsu Province.One hundred ninety-six patients were studied,including 3 patients with acute HBV,141 with chronic HBV,18 with compensatory cirrhosis,22 with decompensated cirrhosis,and 12 with liver cancer.This study adopted a questionnaire method to investigate and calculate the direct and indirect economic burden of the subjects according to disease economic burden theories and methods.Multiple linear stepwise regression was used for analysis of the influencing factors for economic burden of inpatients with HBV-related diseases.Results:The average economic burden for the 196 inpatients investigated was RMB 28,971.The direct economic burden was RMB 19,916(68.7%),including direct medical costs(RMB 19,087;95.8%)and direct non-medical costs(RMB 829;4.2%).The indirect economic burden was RMB 9055(31.3%),including patient-related expenses(RMB 6348;70.1%)and nursing expenses(RMB 2707;29.9%).According to the multiple linear stepwise regression analysis results,the hospital stay,proportion of medicine,age,and disease type affected the economic burden of the patients(P<0.05).Conclusion:Patients with HBV-related diseases undertake a heavy economic burden for hospitalization,especially the direct economic burden.Therefore,the inpatients’economic burden can be reduced by shortening the hospital stay,reducing the medical expenses reasonably,and delaying the progression of disease as far as possible according to medical standards. 展开更多
关键词 Hepatitis B Economic burden Influencing factor Hospital stay Medical expenses Progression of disease
Developing a framework for identifying risk factors and estimating direct economic disease burden attributable to healthcare-associated infections:a case study of a Chinese Tuberculosis hospital 认领 引用
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作者 Nili Ren Xinliang Liu +6 位作者 Yi Luo Guofei Li Ying Huang Desheng Ji Cheng Peng Jing Sun Hao Li 《Global Health Research and Policy》 2024年第1期251-261,共11页
Healthcare-associated infections(HAIs)represent a major global health burden,which necessitate effective frame-works to identify potential risk factors and estimate the corresponding direct economic disease burden.In ... Healthcare-associated infections(HAIs)represent a major global health burden,which necessitate effective frame-works to identify potential risk factors and estimate the corresponding direct economic disease burden.In this article,we proposed a framework designed to address these needs through a case study conducted in a Tuberculosis(TB)hospital in Hubei Province,China,using data from 2018 to 2019.A comprehensive multistep procedure was devel-oped,including ethical application,participant inclusion,risk factor identification,and direct economic disease burden estimation.In the case study,ethical approval was obtained,and patient data were anonymized to ensure privacy.All TB hospitalized patients over the study period were included and classified into groups with and without HAIs after screening the inclusion and exclusion criteria.Key risk factors,including gender,age,and invasive proce-dure were identified through univariate and multivariate analyses.Then,propensity score matching was employed to select the balanced groups with similar characteristics.Comparisons of medical expenditures(total medical expenditure,medicine expenditure,and antibiotics expenditure)and hospitalization days between the balanced groups were calculated as the additional direct economic disease burden measures caused by HAIs.This frame-work can serve as a tool for not only hospital management and policy-making,but also implementation of targeted infection prevention and control measures.Moreover,it has the potential to be applied in various healthcare set-tings at local,regional,national,and international levels to identify high-risk areas,optimize resource allocation,and improve hospital management and governance,as well as inter-organizational learning.Challenges to imple-ment the framework are also raised,such as data quality,regulatory compliance,considerations on unique nature of communicable diseases and other diseases,and training need for professionals. 展开更多
关键词 Healthcare-associated infections Risk factors Direct economic disease burden Case study Framework
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Study on the disease burden and influencing factors of patients with paroxysmal nocturnal hemoglobinuria in China 认领 引用
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作者 Shengnan Duan Huaxin Yu +9 位作者 Rong Fu Zixuan Lv Pei Wang Hanyu Chang Yaqun Wang Hanxiang Chen Fanyu Dong Zhe Hao Sijia Che Ni Yuan 《Pharmacoeconomics and Policy》 2025年第2期100-106,共7页
Paroxysmal nocturnal hemoglobinuria(PNH)is a rare,chronic,and life-threatening hematologic disorder that affects individuals across all age groups,resulting in significant long-term healthcare costs and a substantial ... Paroxysmal nocturnal hemoglobinuria(PNH)is a rare,chronic,and life-threatening hematologic disorder that affects individuals across all age groups,resulting in significant long-term healthcare costs and a substantial economic burden.This study aims to explore the economic burden and influencing factors of PNH in China,providing evidence for policymaking.A cross-sectional survey was conducted in 2022 through PNH China,one of the largest public welfare mutual aid organizations for PNH patients in China.An online questionnaire was used to collect data on socio-demographic characteristics,clinical information,diagnosis and treatment details,and healthcare-related costs from 329 PNH patients.Multiple linear regression analysis,with the significance level ofα=0.05,was employed to analyze the influencing factors of economic burden.The total economic burden of 329 PNH patients during the past year was 20,343,037 Chinese Yuan(CNY),comprising direct medical costs of 9,075,400 CNY,direct non-medical costs of 3,162,269 CNY,and indirect costs of 8,105,368 CNY.Initial clinical symptoms,including abdominal pain and back pain,along with thrombotic complications,had a significant impact on the economic burden faced by patients and their families.The findings underscore the severe financial strain faced by patients and families,highlighting the need for targeted policy measures such as expanding insurance coverage for PNH-specific therapies,establishing dedicated funds for rare diseases,and integrating PNH into critical illness insurance schemes.These measures would alleviate financial strain and enhance the healthcare security system for patients with rare diseases to improve their well-being. 展开更多
关键词 Paroxysmal nocturnal hemoglobinuria Economic burden Influencing factors A cross sectional survey Patients’perspective
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Targeting Wallerian degeneration in glaucoma 认领 引用
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作者 Melissa Jöe Pete A.Williams 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期693-694,共2页
Neurodegenerative diseases account for a large and increasing health and economic burden worldwide.With an increasingly aged population,this burden is set to increase.Optic neuropathies make up a large proportion of n... Neurodegenerative diseases account for a large and increasing health and economic burden worldwide.With an increasingly aged population,this burden is set to increase.Optic neuropathies make up a large proportion of neurodegenerative diseases with glaucoma being highly prevalent.Glaucoma is characterized by the progressive dysfunction and loss of retinal ganglion cells and their axons which make up the optic nerve.It is the leading cause of irreversible vision loss and affects an estimated 80 million people.The mammalian central nervous system is non-regenerative and,once lost or injured,retinal ganglion cells cannot regenerate an axon into the optic nerve under basal conditions.Thus,strategies that provide neuroprotection to stressed,dysfunctional,or dying retinal ganglion cells are likely to be of high therapeutic and translational value.Advancing age,genetics,and elevated intraocular pressure are all major risk factors for glaucoma,however,all clinically available glaucoma treatments focus on intraocular pressure management and do not directly address the neurodegenerative component of glaucoma. 展开更多
关键词 health burden neurodegenerative diseases aged population Wallerian degeneration glaucoma vision loss economic burden retinal ganglion cells their axons
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Economic costs of alcohol consumption in Thailand,2021 认领 引用
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作者 Chaisiri Luangsinsiri Sitaporn Youngkong +2 位作者 Usa Chaikledkaew Oraluck Pattanaprateep Montarat Thavorncharoensap 《Global Health Research and Policy》 2023年第1期27-34,共8页
Background Alcohol is one of the leading risk factors contributing to avoidable economic loss worldwide.Estimates from the economic cost of alcohol consumption studies play an important role in prioritizing healthcare... Background Alcohol is one of the leading risk factors contributing to avoidable economic loss worldwide.Estimates from the economic cost of alcohol consumption studies play an important role in prioritizing healthcare resource use,supporting policy decisions,and justifying budgets for alcohol policy.This study aimed to estimate the economic burden associated with alcohol consumption in Thailand in 2021.Methods Prevalence-based cost of illness methodology was employed.The following costs were included in the analysis:healthcare costs;cost of law enforcement;cost of property damage due to road traffic accidents;cost of premature mortality;and cost of absenteeism from out-patient hospital visits and hospitalization.Human capital approach was adopted.All costs were presented in Thai baht,2021.Results Alcohol consumption incurred a total estimated economic cost of 165,450.5 million baht,equivalent to 1.02%of Gross Domestic Product(GDP)and 2500 baht per capita.Cost of premature mortality was estimated at 157,918.7 million baht and accounted for the largest proportion of the total cost(95.45%).Healthcare cost was found to be the second highest share representing 4370.1 million baht(2.7%of the total cost).The number of premature death attributable to alcohol consumption in 2021 was estimated at 22,804.Conclusions Alcohol continues to impose a substantial economic burden in Thailand.Enforcement of existing wellformulated alcohol control policies is urgently required to mitigate the economic impact of alcohol consumption in the country. 展开更多
关键词 Cost-of-illness Economic burden Alcohol Cost Drinking
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The China Alzheimer Report 2025 认领 引用 被引量：46
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作者 Nan Zhi Rujing Ren +35 位作者 Jinlei Qi Xinya Liu Zike Yun Shaohui Lin Yisong Hu Haixia Li Xinyi Xie Jintao Wang Jianping Li Yikang Zhu Mengyi Gao Junjie Yang Yiran Wang Yurong Jing Jieli Geng Wenwei Cao Qun Xu Xiaoping Yu Yuan Zhu Ying Zhou Lin Wang Chao Gao Binyin Li Shengdi Chen Fang Yuan Ronghua Dou Xiaoyun Liu Xuena Li Yafu Yin Yan Chang Gang Xu Yanting Zhong Chunbo Li Ying Wang Maigeng Zhou Gang Wang 《General Psychiatry》 CAS CSCD 2025年第4期245-259,共15页
With the sustained growth of the economy and significant changes in social demographics,the issue of elderly-related diseases has increasingly drawn attention,particularly.Alzheimer’s disease(AD),as a representative ... With the sustained growth of the economy and significant changes in social demographics,the issue of elderly-related diseases has increasingly drawn attention,particularly.Alzheimer’s disease(AD),as a representative disease of neurodegenerative diseases,has become a major challenge,affecting the health and quality of life of the elderly population severely.In recent years,the incidence,prevalence and mortality rates of AD have increased in China,imposing substantial economic burdens on families,society and the entire healthcare system.To proactively address this challenge and respond to the national‘Healthy China Action’initiative,leading experts from authoritative institutions jointly authored the China Alzheimer Report 2025.Building on previous editions,this report updates epidemiological data on AD in China,thoroughly analyses the latest economic burdens of the disease and comprehensively evaluates the current status of AD diagnosis and treatment services,as well as the allocation of public health resources in our country.Its release reflects China’s progress in AD research and prevention,underscores societal concern for elderly health and aims to provide scientific guidance and data support for AD prevention,diagnosis and treatment.It also facilitates academic exchanges and cooperation,enhancing public awareness and promoting active participation in elderly healthcare,towards achieving‘healthy ageing’in China. 展开更多
关键词 elderly health healthy aging diagnosis treatment economic burden China societal concern Alzheimers disease public health resources
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The function of miR-210 in cardiovascular diseases 认领 引用
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作者 Hong-Jin Chen Ai-Fang Wang +2 位作者 Ying-Nan Song Dong-Liang Yang Xiong Chen 《Biomedical Engineering Communications》 CAS 2025年第4期1-3,共3页
Cardiovascular disease(CVD)represents the foremost cause of mortality globally,imposing a substantial economic burden.In 2021,approximately 19.4 million deaths were attributed to cardiovascular conditions,constituting... Cardiovascular disease(CVD)represents the foremost cause of mortality globally,imposing a substantial economic burden.In 2021,approximately 19.4 million deaths were attributed to cardiovascular conditions,constituting 32%of global mortality[1].Over three-quarters of these fatalities occurred in low and middle-income nations.Notably,ischemic heart disease and stroke were responsible for 84%of CVD-related deaths.Among them,the number of cases of ischemic cardiomyopathy increased by 68%in 2021 compared to 1990(Figure 1A). 展开更多
关键词 ischemic cardiomyopathy stroke heart disease cardiovascular disease cvd represents mortality economic burden cardiovascular diseases ischemic heart disease
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Expenditure of hospital care on cancer in China, from 2011 to 2015 认领 引用 被引量：106
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作者 Yue Cai Ming Xue +5 位作者 Wanqing Chen Maogui Hu Zhiwen Miao Lan Lan Rongshou Zheng Qun Meng 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2017年第3期253-262,共10页
Objective: A solid understanding of levels and trends of spending on cancer is important to evaluate whether our healthcare resources were wisely spent and to prioritize future resources for cancer treatment and preve... Objective: A solid understanding of levels and trends of spending on cancer is important to evaluate whether our healthcare resources were wisely spent and to prioritize future resources for cancer treatment and prevention. However, studies on economic burden of cancers in China are scant and the results are inconsistent. Methods: The Chinese hospital information database and nearly 350 million inpatient medical record data were used. As the ratios of cancer inpatient payments to total inpatient payments were mainly influenced by the grades and sites of hospitals, the estimates of payments of cancer inpatients in this study were stratified by hospital grades and provinces. Only the payments of cancer inpatients happened in grade 2, grade 3 and specialized cancer hospitals were included in the analyses. The total medical payments of cancers in China were estimated based on the ratios of outpatient payments to inpatient payments in specialized cancer hospitals. Results: From 2011 to 2015, the payments of cancer inpatients in China have increased by 84.1% and the total inpatient payments reached 177.1 billion RMB in 2015, accounting for 4.3% of the total health expenditure in China. Based on the ratio of outpatient payments to inpatient payments, the total payments on cancer treatments in China were estimated to be 221.4 billion RMB in 2015. Among different cancer types, the highest payments were the treatment of trachea, bronchus and lung cancer. The major cancer inpatient payments (67.1% in 2015) spent in grade 3 general hospitals and this ratio increased continually from 2011 to 2015. The expenditure of cancer treatments also varies by region with the major expenditure in the eastern region of China. Conclusions: This study estimated the total payments of cancer treatments in China and analyzed how the money was spent on cancer treatments in the recent 5 years, which would provide information for decision makings on the allocation of resources to service provisioning, prevention strategies, research funding, and assessing whether the economic burden of cancer is affordable to the governments. 展开更多
关键词 Cancer payments expenditure economic burden
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Contemporary trends on expenditure of hospital care on total cancer and its subtypes in China during 2008-2017 认领 引用 被引量：23
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作者 Yue Cai Wanqing Chen +4 位作者 Xiaoxu Wang Xue Xia Xiang Cui Shiyong Wu Jinghua Li 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2021年第5期627-636,共10页
Objective:To describe the contemporary trends in total,inpatient,and outpatient expenditure on major subtypes of cancer in different classifications of hospitals in China's Mainland.Methods:Home page of Inpatient ... Objective:To describe the contemporary trends in total,inpatient,and outpatient expenditure on major subtypes of cancer in different classifications of hospitals in China's Mainland.Methods:Home page of Inpatient Medical Records(HIMRs)and Hospital Annual Reports(HARs)were used to estimate hospital care expenditure on cancer.Inpatient payments and their share of cancer were calculated with the top-down method.Kriging spatial interpolation methods were used at the county level and summed at the province level.Outpatient expenditure was estimated with inpatient expenditure and the ratios of outpatient to inpatient payments in specialized cancer hospitals,stratified by province.Total expenditure on cancer was the sum of both payments.Log-linear regression was applied to estimate annual percentage change(APC)of expenditure.Results:Total expenses for cancer of Chinese residents reached up to 304.84 billion Chinese Yuan(CNY)in2017,accounting for 5.8%of the total health expenses(THE).After adjusting for consumer price index(CPI),medical expenses for cancer have increased from 63.30 billion CNY in 2008 to 249.56 billion CNY in 2017[APC:15.2%,95%confidence interval(95%CI):13.4%-17.0%].The APC was slightly higher than THE around 2013,while was lower after 2013.During 2008-2017,the ratio of inpatient to outpatient costs for cancer decreased from4.3:1 to 3.8:1.The inpatient payments for cancer mainly happened in grade 3 general hospitals,East China,and among lung,colorectal,and stomach cancer;while the fastest increase was found in West China,and among thyroid,prostate,and colorectal cancer.Conclusions:During 2008-2017,the rapid growth trend of medical expenses for cancer has been effectively controlled with the continuous deepening of medical reform and improvements of residents’health care.More attention should be paid to potential increases of medical costs caused by technological progress and demand release.Socialized and multi-channel insurance financing modes should be explored in the future. 展开更多
关键词 Cancer payments expenditure economic burden
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