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Passenger Escalator Fall Detection Algorithm Based on SCGD-Yolo11m-Pose 认领 引用
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作者 Huidi Zhang Shijie Jia Shaoyuan Xu 《Journal of Electronic Research and Application》 2026年第5期37-53,共17页
Escalator fall detection algorithms in subway stations are a crucial means of preventing passenger accidents.However,in a real scene,issues such as the loss of small objects due to scale changes and interference cause... Escalator fall detection algorithms in subway stations are a crucial means of preventing passenger accidents.However,in a real scene,issues such as the loss of small objects due to scale changes and interference caused by complex backgrounds can lead to false positives and false negatives.This paper proposes a passenger escalator fall detection algorithm based on SCGD-Yolo11m-pose network.First,RFD module was introduced during the downsampling stage to improve the robustness of feature extraction.Second,in C2PSA,deformable attention was used and named C2DA.This enables the model to enhance its ability to perceive various falling poses in complex backgrounds.Finally,in neck network,Gold-Yolo structure replaces the PANet network to strengthen the recombination ability of multi-scale features and improves the accuracy of the model in complex background.Additionally,only four keypoints defined by COCO,both shoulders and both hips,are retained,which improves computational efficiency.Experimental results on our self-built subway escalator fall dataset show that the improved model is improved by 2.3%on AP50 and 2.5%on AP50:95.This validates the effectiveness and practicality of the proposed algorithm in ensuring the safety monitoring of subway passengers. 展开更多
关键词 Pose estimation Escalator Fall detectionYOLOv11-pose Deformable attention Gold-YOLO
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Cellular automaton modeling of pedestrian movement behavior on an escalator 认领 引用 被引量：4
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作者 Fu-Rong Yue Juan Chen +2 位作者 Jian Ma Wei-Guo Song Siu-Ming Lo 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第12期328-333,共6页
As a convenient passenger transit facility between floors with different heights, escalators have been extensively used in shopping malls, metro stations, airport terminals, etc. Compared with other vertical transit f... As a convenient passenger transit facility between floors with different heights, escalators have been extensively used in shopping malls, metro stations, airport terminals, etc. Compared with other vertical transit facilities including stairs and elevators, escalators usually have large transit capacity. It is expected to reduce pedestrian traveling time and thus improve the quality of pedestrian’s experiences especially in jamming conditions. However, it is noticed that pedestrians may present different movement patterns, e.g., queuing on each step of the escalator, walking on the left-side and meanwhile standing on the right-side of the escalator. These different patterns affect the actual escalator traffic volume and finally the passenger spatiotemporal distribution in different built environments. Thus, in the present study, a microscopic cellular automaton(CA) simulation model considering pedestrian movement behavior on escalators is built. Simulations are performed considering different pedestrian movement speeds, queuing modes, and segregation on escalators with different escalator speeds.The actual escalator capacities under different pedestrian movement patterns are investigated. It is found that walking on escalators will not always benefit escalator transit volume improvement, especially in jamming conditions. 展开更多
关键词 cellular automaton pedestrian movement escalator capacity
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The quality of escalator signage for public safety in Malaysia:an observational study 认领 引用
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作者 Chii-Chii Chew Chee-Tao Chang +10 位作者 Xin-Jie Lim Hasni-Adha Ibrahim Hamiazwa Azmi Nur-Ilyana Wahabi Nur-Shuhaida Hamdan Nurul-Atiqah Nazan Nur-Haliana Karim Nurfarahdila-Ahmad Malawi Ying-Ling Oon Norshazila-Julia MS Amar-Singh HSS 《Global Health Journal》 2021年第4期198-203,共6页
Objective:Escalator signage could be playing a vital role to alert users for safe use of escalators.This study aimed to evaluate the availability,standardization,and content of safety information on escalator signage ... Objective:Escalator signage could be playing a vital role to alert users for safe use of escalators.This study aimed to evaluate the availability,standardization,and content of safety information on escalator signage in the shopping malls.Methods:An observational study was conducted from November 2017 to February 2018 to assess the availability,standardization of safety information among the signage inside the shopping mall,and the content of safety information for public safety in Malaysia.A checklist was developed by adapting escalator safety guidelines from seven countries and regions including Malaysia.Data collctors identified from the selected states were required to capture three photographs at different angles of the escalator signage for each ascending and descending directions at each entrance of the mall.Descriptive analysis was performed;each criterion was presented in frequency and percentage.Results:A total of 268 escalators from 84 shopping malls in 9 states of Malaysia were assessed.Two operating escalators were not equipped with signage.More than one-ifth(23.0%)of the signage was not standardized within the mall.The majority of safety information was displayed in the form of a pictogram,a minority of signage displayed information in both pictogram and text format:"children must hold hand"(12.7%)and"be careful of long clothing"(10.8%),respectively.Nevertheless,"toddlers should be carried"(8.6%)and"take extra care with rubber shoesied shoes/laces"(30.2%)were found absent in most of the signage.Conclusion:Escalator signage was present in almost all of the escalators observed.However,non-standardization of the signage of escalators should warrant the attention of relevant authorities to revise the safety guideline s and improve the quality of escalator. 展开更多
关键词 Elevators and escalators Safety Transportation facilities Environment and public health Malaysia
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Research on Configuration Optimization of Escalator Assembly Profiles based on SAP System 认领 引用
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作者 WU Jianlong SHANG Rui 《International Journal of Plant Engineering and Management》 2018年第4期247-254,共8页
A new method for quantity configuration of escalator linear profile in SAP system is proposed. This method is to create the calculation formula of the assembly length of escalator linear profile according to the chara... A new method for quantity configuration of escalator linear profile in SAP system is proposed. This method is to create the calculation formula of the assembly length of escalator linear profile according to the characteristic value of escalator, the requirements of assembly process and the technical specification of packaging and transportation,and then optimize the configuration method in SAP system. It avoids the waste caused by the SAP system configuration of 6 m long profile that needs to be cut to the actual length,which reduce the scrap rate of escalator assembly profiles. It provides an example to reduce manufacturing cost by improving the configuration in SAP system without change of assembly process. 展开更多
关键词 escalator profiles configuration optimize SAP system
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Should We Stand on Right and Walk on Left Side of Escalators? 认领 引用
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《ChinAfrica》 2019年第6期12-13,共2页
While taking an escalator, which side do you habitually stand on? When you are in a hurry, do you walk on the escalator to save time? Most of the major cities in China follow the "stand-right, walk-left" mle... While taking an escalator, which side do you habitually stand on? When you are in a hurry, do you walk on the escalator to save time? Most of the major cities in China follow the "stand-right, walk-left" mle for escalators, that is to say, riders should stand on the right side and walk on the left side. Gradually, this rule has been followed by many people and has become the norm. In April this year, however, the Shang hai Metro released the latest version of its escalator instructions, which don't mention the "stand-right, walk-left" rule but, instead, prohibit walking on the escalators.This change disrupted the long-standing consensus and aroused heated discussion. 展开更多
关键词 escalator habitually hurry
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Analysis and Research on the Safe Use of Special Equipment Elevators, Escalators and Moving Sidewalks 认领 引用
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作者 LURong 《外文科技期刊数据库（文摘版）工程技术》 2022年第7期022-025,共4页
At present, with the continuous development of Chinas social economy, it has further promoted Chinas urbanization. However, in the process of sustainable urbanization, urban land resources are becoming more and more t... At present, with the continuous development of Chinas social economy, it has further promoted Chinas urbanization. However, in the process of sustainable urbanization, urban land resources are becoming more and more tense, which makes more and more high-rise buildings in cities rise gradually. Among them, in order to ensure good transportation, the use of special equipment elevators, escalators and moving sidewalks is increasing. But at the same time, in the process of using the special equipment elevator, escalator and moving sidewalk, it will also be affected by some factors, which leads to the safety problem of using the special equipment elevator, escalator and moving sidewalk. This requires enterprises and staff to further improve the safety management of special equipment elevators, escalators and moving sidewalks, including regular inspection, maintenance and safety education. Therefore, in order to further improve the safety of special equipment elevator escalators, this paper mainly introduces the special equipment elevator escalators. The necessity of safe use of special equipment elevators, escalators and moving sidewalks; Measures for the safe use of special equipment elevators, escalators and moving sidewalks. From many angles, this paper puts forward specific feasible methods, which can provide effective reference for the follow-up work. 展开更多
关键词 special equipment elevator escalator moving sidewalk safe use analysis and research
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Reversing Outdated Escalator Etiquette 认领 引用
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《Beijing Review》 2025年第23期48-48,共1页
Recently,small footprint stickers have appeared on escalators in.some subway stations in Beijing.Subway operators say these“footprints”are placed there to remind passengers they don't have to“stand on the right... Recently,small footprint stickers have appeared on escalators in.some subway stations in Beijing.Subway operators say these“footprints”are placed there to remind passengers they don't have to“stand on the right and walk on the left”of escalators but can instead stand side-by-side with another passenger. 展开更多
关键词 footprint stickers escalator etiquette footprints subway stations Beijing passenger behavior
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Axillary surgery de-escalation for breast cancer in the era of precision medicine 认领 引用 被引量：1
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作者 Xueying Du Xiao Sun +3 位作者 Yanbing Liu Zhaopeng Zhang Yongsheng Wang Zhao Bi 《Cancer Biology & Medicine》 SCIE CAS CSCD 2025年第8期871-873,共3页
In the era of precision medicine,the breast cancer surgical treatment field is gradually moving toward a de-escalation model.Through precise preoperative assessments and multidisciplinary decision-making,surgical trau... In the era of precision medicine,the breast cancer surgical treatment field is gradually moving toward a de-escalation model.Through precise preoperative assessments and multidisciplinary decision-making,surgical trauma can be decreased,and patients’quality of life can be improved by ensuring safety.Herein,we explore the axillary de-escalation surgery model for breast cancer. 展开更多
关键词 surgical trauma quality life precision medicinethe breast cancer surgery breast cancer precision medicine axillary de escalation
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Optimizing management of sentinel lymph node limited residual tumor after neoadjuvant therapy for breast cancer:Balancing of act 认领 引用 被引量：1
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作者 Jing Sun Zhiqiang Shi +1 位作者 Zhao Bi Pengfei Qiu 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2025年第2期293-295,共3页
Introduction The accuracy of sentinel lymph node biopsy(SLNB)after neoadjuvant therapy(NAT)has been confirmed in clinical nodal stage 1(c N1)patients,and more patients could benefit from axillary surgery de-escalation... Introduction The accuracy of sentinel lymph node biopsy(SLNB)after neoadjuvant therapy(NAT)has been confirmed in clinical nodal stage 1(c N1)patients,and more patients could benefit from axillary surgery de-escalation after NAT(1,2). 展开更多
关键词 sentinel lymph node biopsy clinical nodal stage neoadjuvant therapy nat sentinel lymph node biopsy slnb axillary surgery de escalation accuracy residual tumor neoadjuvant therapy
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Morphological,physiological,and molecular mechanisms underlying heat stress memory in plants 认领 引用
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作者 Yi Liu Yang Sun +6 位作者 Pinke Lv Yankai Li Fei Ding Fangling Jiang Xiaoming Song Zhen Wu Rong Zhou 《Vegetable Research》 2025年第1期154-158,共5页
Increasing climatic unpredictability makes plants suffer different environmental stresses,with escalating global temperatures positioning heat stress as a principal abiotic constraint.Exposure to excessive heat destab... Increasing climatic unpredictability makes plants suffer different environmental stresses,with escalating global temperatures positioning heat stress as a principal abiotic constraint.Exposure to excessive heat destabilizes cellular homeostasis,impairing growth trajectories and photosynthetic capacity while potentially triggering irreversible physiological impairments.Nevertheless,plants exhibit stress-priming capabilities through heat-induced molecular memory mechanisms that bolster tolerance to recurrent thermal challenges.In the context of global warming,elucidating the mechanisms underlying plants'heat stress memory and response is crucial for improving crops'resilience and adaptation.This review systematically elaborated the morphological,physiological,and molecular mechanisms underlying heat stress memory,in which phytohormones are key signaling molecules regulating the stress memory.The role of Hsfs(heat shock transcription factor),HSPs(heat shock proteins),and genetic and epigenetic regulation in plant heat stress memory were clarified.Furthermore,the factors(e.g.,priming and recovery duration,species,and genotype differences)affecting heat stress memory were clarified.This study will contribute to mitigating the adverse effects of global warming on crop productivity and propose novel strategies for incorporating these findings into molecular breeding programs to enhance crop thermotolerance. 展开更多
关键词 heat stress cellular homeostasisimpairing heat stress memory escalating global temperatures physiological impairmentsneverthelessplants photosynthetic capacity molecular mechanisms morphological mechanisms
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Escalation of soya cross-allergy in infants with cow's milk allergy 认领 引用
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作者 Bhaswati C Acharyya Meghdeep Mukhopadhyay 《World Journal of Clinical Pediatrics》 2025年第2期88-92,共5页
BACKGROUND Cow's milk allergy(CMA)is a common condition in infants,requiring alternative protein sources in their diets.Soya milk has become a popular substitute,especially in developing countries where it is a mo... BACKGROUND Cow's milk allergy(CMA)is a common condition in infants,requiring alternative protein sources in their diets.Soya milk has become a popular substitute,especially in developing countries where it is a more affordable option compared to expensive hypoallergenic feeds for infants with insufficient breast milk supply.However,recent observations have shown an increase in soya cross-allergic reactions among infants with CMA.AIM To determine how often infants diagnosed with CMA also had soya cross-allergy and to examine the symptoms and outcomes of these infants at 2 years of age.METHODS Data from two pediatric centers were analyzed,looking at clinical records of children under 2 years old diagnosed with CMA from August 2015 to July 2023,divided into two four-year periods.RESULTS The records of 432 infants with CMA were analyzed.In the first four-year period from August 2015 to July 2019,142 infants were studied,with 27(19%)found to have soya-protein allergy as well.In the second four-year period,a total of 290 infants were studied,and soya allergy was found in 136 babies(47%).This represents a significant increase(P<0.0001)in cases of soya protein cross-allergy among infants with CMA.The most common symptoms observed were gastroesophageal reflux disorder(39%),followed by failure to thrive,bloody diarrhea,watery diarrhea,and constipation.At 2 years of age,these infants showed significant growth failure compared to infants with CMA only.CONCLUSION In conclusion,this study emphasizes the importance of being cautious when using soy protein in infants with cow's milk protein allergy,especially in areas where cost is a major concern. 展开更多
关键词 Cow's milk allergy Soya allergy Escalation of allergy Infants IgE mediated Non-IgE mediated
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Optimization Scheme of Large Passenger Flow in Huoying Station,Line 13 of Beijing Subway System 认领 引用 被引量：5
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作者 Jin Zhou Haochen Wang +3 位作者 Di Sun Siqiang Xu Meng Lv Feifei Yu 《Computers, Materials & Continua》 SCIE EI 2020年第6期1387-1398,共12页
This paper focuses on the distribution of passenger flow in Huoying Station,Line 13 of Beijing subway system.The transformation measures taken by Line 13 since operation are firstly summarized.Then the authors elabora... This paper focuses on the distribution of passenger flow in Huoying Station,Line 13 of Beijing subway system.The transformation measures taken by Line 13 since operation are firstly summarized.Then the authors elaborate the facilities and equipment of this station,especially the node layout and passenger flow field.An optimization scheme is proposed to rapidly distribute the passenger flow in Huoying Station by adjusting the operation time of the escalator in the direction of Xizhimen.The authors adopt Queuing theory and Anylogic simulation software to simulate the original and the optimized schemes of Huoying Station to distribute the passenger flow.The results of the simulation indicate that the optimized scheme could effectively alleviate the traffic congestion in the hall of Huoying Station,and the pedestrian density in other places of the hall is lowered;passengers could move freely in the hall and no new congestion points would form.The rationality of the scheme is thus proved. 展开更多
关键词 Huoying station of Beijing subway system passenger flow escalator queuing theory system simulation Anylogic
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RESEARCH ON THE MOIRE CHROMATOGRAPHY TECHNIQUE AND ITS APPLICATION 认领 引用
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作者 TIANZE LI SHUYUN WANG 《Journal of Innovative Optical Health Sciences》 SCIE EI 2009年第2期137-142,共6页
This paper explains the Moire chromatography technique and the optical characteristics when the light crosses the 3D air flow field.Based on this,taking grating,CCD camera,optical filter and diaphragm as the main devi... This paper explains the Moire chromatography technique and the optical characteristics when the light crosses the 3D air flow field.Based on this,taking grating,CCD camera,optical filter and diaphragm as the main device,a multi-direction Moire chromatography optical system was designed.The system consists of five detective light paths,in each detective light path there is parallel and same periodic grating and filtering minipore placed on the lens’focal length plane;the grating is used to adjust the space length and angle between the two gratings,and the filtering minipore is used to remove the unorderly high frequency intermix in the Moire fringe.Utilizing the computer escalator method to convert the tested value,the vivid interference fringe of tested parameter can be obtained.The application of this system in precision measurement and medicine is also analyzed and discussed. 展开更多
关键词 Moire chromatography optical system computer escalator method medicine
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Intensity modulated radiation therapy with simultaneous integrated boost based dose escalation on neoadjuvant chemoradiation therapy for locally advanced distal esophageal adenocarcinoma 认领 引用 被引量：1
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作者 Ming Zeng Fernando N Aguila +4 位作者 Taral Patel Mark Knapp XueQiang Zhu XiLin Chen Phillip D Price 《World Journal of Gastrointestinal Oncology》 SCIE 2016年第5期474-480,共7页
AIM:To evaluate impact of radiation therapy dose escalation through intensity modulated radiation therapy with simultaneous integrated boost(IMRT-SIB).METHODS:We retrospectively reviewed the patients who underwent fou... AIM:To evaluate impact of radiation therapy dose escalation through intensity modulated radiation therapy with simultaneous integrated boost(IMRT-SIB).METHODS:We retrospectively reviewed the patients who underwent four-dimensional-based IMRT-SIBbased neoadjuvant chemoradiation protocol.During the concurrent chemoradiation therapy,radiation therapy was through IMRT-SIB delivered in 28 consecutive daily fractions with total radiation doses of 56 Gy to tumor and 5040 Gy dose-painted to clinical tumor volume,with a regimen at the discretion of the treating medical oncologist.This was followed by surgical tumor resection.We analyzed pathological completion response(p CR)rates its relationship with overall survival and event-freesurvival.RESULTS:Seventeen patients underwent dose escalation with the IMRT-SIB protocol between 2007 and 2014 and their records were available for analysis.Among the IMRT-SIB-treated patients,the toxicity appeared mild,the most common side effects were grade 1-3 esophagitis(46%)and pneumonitis(11.7%).There were no cardiac events.The Ro resection rate was 94%(n=16),the p CR rate was 47%(n=8),and the postoperative morbidity was zero.There was one mediastinal failure found,one patient had local failure at the anastomosis site,and the majority of failures were distant in the lung or bone.The 3-year diseasefree survival and overall survival rates were 41%(n=7)and 53%(n=9),respectively.CONCLUSION:The dose escalation through IMRT-SIB in the chemoradiation regimen seems responsible for down-staging the distal esophageal with well-tolerated complications. 展开更多
关键词 Intensity modulated radiation therapy Esophageal adenocarcinoma Simultaneous integrated boost Neoadjuvant chemoradiation Dose escalation Resection rate
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The fossil record of durophagous predation in the James Ross Basin over the last 125 million years 认领 引用 被引量：1
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作者 Elizabeth MHARPER JAlistair CRAME Alice M PULLEN 《Advances in Polar Science》 CSCD 2019年第3期199-209,共11页
We review the evidence for predation of shelly benthic prey over 125 million years of earth history in the James Ross Basin,Antarctica(~65°S).Although poor in the Early Cretaceous lower parts of the sequence,whic... We review the evidence for predation of shelly benthic prey over 125 million years of earth history in the James Ross Basin,Antarctica(~65°S).Although poor in the Early Cretaceous lower parts of the sequence,which represent essentially deeper water facies,evidence for both potential crushers and drillers becomes more apparent in the Santonian–Campanian Santa Marta Formation,and by the Maastrichtian López de Bertodano Formation there is an extensive fossil record of drill holes attributable to naticid gastropods,and some evidence of crushing by decapods crustaceans and possibly other taxa too.This continues at a similar level of intensity across the K/Pg boundary into the Danian Sobral Formation,but is less well constrained in the latest Paleocene–Early Eocene.The most extensive record of predation occurs in the Middle Eocene section of the La Meseta Formation on Seymour Island which also records the highest levels of benthic diversity within the entire basin.This key section is providing some important new evidence to suggest that the rate of acceleration of benthic predation intensity through the Late Mesozoic–Early Cenozoic in the polar regions may be similar to that seen in lower latitude regions.Predator–prey interaction was a key factor in the evolution of polar marine faunas too. 展开更多
关键词 drilling crushing molluscs escalation Seymour Island
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A New SDH-Based ATM Network Survivability Escalation Mechanism 认领 引用 被引量：1
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作者 隆克平 金跃辉 程时端 《High Technology Letters》 EI CAS 2000年第1期29-34,共6页
This paper investigates survivability escalation strategies in multi layers transport networks such as ATM/SDH/WDM networks, and presents oriented failures and oriented traffic escalation mechanisms. Furthermore, We p... This paper investigates survivability escalation strategies in multi layers transport networks such as ATM/SDH/WDM networks, and presents oriented failures and oriented traffic escalation mechanisms. Furthermore, We present a new survivability Escalation strategy for SDH Based ATM transport networks, which addresses difficult problem for resources sharing pool(RSP) among different layers restoration mechanisms. In this paper, we also present integer programming (IP) model for the resources sharing pool (RSP) design problem and the node simulation model for escalation Node. The simulation results show that the proposed ESP is very efficient. The proposed model can be easily extended for other types of multi layer networks, such as WDM based ATM networks or WDM based SDH networks. 展开更多
关键词 Survivability SDH based ATM networks Escalation strategies Resources sharing pool(RSP) Integer Programming.
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Chemo-profiling of eucalyptus and study of its hypoglycemic potential 认领 引用 被引量：1
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作者 Baishakhi Dey Analava Mitra 《World Journal of Diabetes》 2013年第5期170-176,共7页
Constant escalations in the number of diabetics worldwide and the failure of conventional therapy to restore normoglycemia without adverse effects,in spite of tremendous strides in modern medicine,calls for naturopath... Constant escalations in the number of diabetics worldwide and the failure of conventional therapy to restore normoglycemia without adverse effects,in spite of tremendous strides in modern medicine,calls for naturopathy and alternative medicine.Because diabetes is multi-factorial and has secondary complications,prevention of hyperglycemia is the central dogma for its management.To date,no oral hypoglycemic exists which can achieve tight glycemic control without side effects.Dietary adjuncts,lifestyle interventions and a resurgence of interest in phyto-therapy have consequently gained ground.Natural hypoglycemics have attracted attention due to ease of incorporation in everyday diet,affordability,less adverse effects,and long term safety.Ethno botanical literature reports more than 800 anti-diabetic plants species.Eucalyptus is well represented in the Aboriginal Pharmacopoeias for its various pharmacological activities.Its hot aqueous decoction has been used as a hypoglycemic in various regions of world.This editorial attempts to summarize the data on the hypoglycemic potential of the different eucalyptus species,highlight the value of its natural biomolecules for the prophylaxis and treatment of type2 diabetes,describe their mechanistic actions,shed light on the posology and safety aspects of eucalyptusand assess its applicability as a reinforcement to currently used therapy. 展开更多
关键词 Normoglycemia Escalations Eucalyptus Central dogma Dietary adjuncts Aboriginal Pharmacopoeias Natural biomolecules Prophylaxis Posology
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Radiation therapy concurrent with weekly cisplatin therapy for loco-regionally advanced nasopharyngeal carcinoma:outcomes of a clinical trial 认领 引用 被引量：4
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作者 Daiyuan Ma Chunqiao Fu Bangxian Tan Mi Liu Xianfu Li Yeqin Zhou 《The Chinese-German Journal of Clinical Oncology》 2011年第4期187-191,共5页
Objective:The purpose of this study was to define the maximum tolerated dose(MTD) by describing the doselimiting toxicity(DLT) of weekly cisplatin concurrently with conventional plus 3-dimensional conformal radiothera... Objective:The purpose of this study was to define the maximum tolerated dose(MTD) by describing the doselimiting toxicity(DLT) of weekly cisplatin concurrently with conventional plus 3-dimensional conformal radiotherapy(CT + 3DCRT) in patients with loco-regionally advanced nasopharyngeal carcinoma(NPC).Methods:Patients with loco-regionally advanced NPC(III/IVa stage) were enrolled into a dose-escalating study.Toxicity was graded according to Common Terminology Criteria for Adverse Events version 3.0(CTCAE v3.0).MTD was defined when 2 of 6 patients developed DLT.The starting dose of cisplatin was 15 mg/m2/w,with a subsequent dose escalation of 5 mg/m2/w in cohorts of 3 new patients.CT + 3DCRT was given to the nasopharynx and the upper neck;the lower neck was treated by a single anterior field irradiation.The prescription dose was 70-80 Gy by 35-40 fractions to the nasopharynx gross tumor,and 66-70 Gy by 33-35 fractions to the positive neck lymph nodes.Results:From Jun.2008 to Sep.2009,24 patients received complete chemoradiotherapy,and all of them were eligible for toxicity evaluation.On the first five dose levels of 15 mg/m2/w and 35 mg/m2/w,no patient experienced DLT.On the next dose level of 40 mg/m2/w,1 patient experienced DLT of grade 3 myelosuppression for 1.4 weeks,and among the additional 3 patients,no one developed DLT.On the seventh dose level of 45 mg/m2/w,all the patients developed grade 3 myelosuppression for more than 1 weeks,and the dose-escalating trial stopped.The 23(95.8%) patients achieved clinical complete remission(CR) in the local site;22(91.7%) achieved CR in the regional site,and all patients got CR 3 months later.After a median follow-up of 16.4 months,1 patient developed liver metastases 2 months later,1 patient developed bone metastases 10 months later and 22 kept disease-free survival.Conclusion:The MTD of cisplatin weekly with concurrent CT + 3DCRT for local advanced NPC is 40 mg/m2/w,with myelosuppression as DLT. 展开更多
关键词 nasopharyngeal carcinoma（NPC） cisplatinreatment chemotherapy radiotherapy concurrent treatment dose escalating
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Dose escalation of external beam radiotherapy for high-risk prostate cancerdImpact of multiple high-risk factor 认领 引用
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作者 Rei Umezawa Koji Inaba +12 位作者 Satoshi Nakamura Akihisa Wakita Hiroyuki Okamoto Keisuke Tsuchida Tairo Kashihara Kazuma Kobayashi Ken Harada Kana Takahashi Naoya Murakami Yoshinori Ito Hiroshi Igaki Keiichi Jingu Jun Itami 《Asian Journal of Urology》 CSCD 2019年第2期192-199,共8页
Objective:To retrospectively investigate the treatment outcomes of external beam radiotherapy with androgen deprivation therapy(ADT)in high-risk prostate cancer in three radiotherapy dose groups.Methods:Between 1998 a... Objective:To retrospectively investigate the treatment outcomes of external beam radiotherapy with androgen deprivation therapy(ADT)in high-risk prostate cancer in three radiotherapy dose groups.Methods:Between 1998 and 2013,patients with high-risk prostate cancer underwent threedimensional conformal radiotherapy or intensity-modulated radiotherapy of 66 Gy,72 Gy,or 78 Gy with ADT.Prostate-specific antigen(PSA)relapse was defined using the Phoenix definition.PSA relapse-free survival(PRFS)was evaluated in each radiotherapy dose group.Moreover,high-risk patients were divided into H-1(patients with multiple high-risk factors)and H-2(patients with a single high-risk factor)as risk subgroups.Results:Two hundred and eighty-nine patients with a median follow-up period of 77.3 months were analyzed in this study.The median duration of ADT was 10.1 months.Age,Gleason score,T stage,and radiotherapy dose influenced PRFS with statistical significance both in univariate and multivariate analyses.The 4-year PRFS rates in Group-66 Gy,Group-72 Gy and Group-78 Gy were 72.7%,81.6%and 90.3%,respectively.PRFS rates in the H-1 subgroup differed with statistical significance with an increasing radiotherapy dose having a more favorable PRFS,while PRFS rates in H-2 subgroup did not differ with increase in radiotherapy dose.Conclusion:Dose escalation for high-risk prostate cancer in combination with ADT improved PRFS.PRFS for patients in the H-1 subgroup was poor,but dose escalation in those patients was beneficial,while dose escalation in the H-2 subgroup was not proven to be effective for improving PRFS. 展开更多
关键词 Prostate cancer External beam radiotherapy Dose escalation Biochemical control
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Optimal use of fielder XT guidewire enhances the success rate of chronic total occlusion percutaneous coronary intervention 认领 引用
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作者 Qian-Cheng Wang Hai-Ruo Lin +8 位作者 Yuan Han Hai Dong Kai Xu Shao-Yi Guan Zhen-Huan Chen Hui-Xin Hao Jian-Ping Bin Yu-Lin Liao Quan-Min Jing 《World Journal of Clinical Cases》 SCIE 2019年第8期928-939,共12页
BACKGROUND Chronic total occlusion(CTO) is found in 18-31% of patients who undergo coronary angiography. Successful recanalization of CTOs is associated with reduced recurrent angina pectoris rates and increased long-... BACKGROUND Chronic total occlusion(CTO) is found in 18-31% of patients who undergo coronary angiography. Successful recanalization of CTOs is associated with reduced recurrent angina pectoris rates and increased long-term survival.Although the success rate of CTO percutaneous coronary intervention(CTO-PCI)has improved, CTO-PCI remains technically challenging. The Fielder XT guidewire was designed for CTO lesions. To validate whether the use of the guidewire increases the success rate, we compared the results of CTO-PCI with or without the guidewire. We hypothesized that the use of Fielder XT guidewire can increase the success rate of CTO-PCI.AIM To investigate whether the use of Fielder XT guidewire increases the final procedural success of CTO-PCI via the anterograde approach.METHODS Between January 2013 and December 2015, a retrospective study was conducted on 1230 consecutive patients with CTO who received PCI via the anterograde approach at the General Hospital of Northern Theater Command. The patients were divided into an XT Group(n = 686) and a no-XT Group(n = 544) depending on whether Fielder XT guidewire was used. Both groups were compared for clinical parameters, lesion-related characteristics, procedural outcomes and inhospital complications. The data were statistically analyzed using Pearson's χ~2 test for categorical variables, and Students' t test was used to compare the quantitative data. Significant independent factors and a risk ratio with 95%confidence interval(CI) were assessed by multivariate logistic regression analysis.RESULTS In total, 1230 patients were recruited; 75.4% of the patients were male, and 55.8%of the patients were in the XT group. The overall success rate was 83.9%, with87.8% in the XT group. Based on multivariate logistic regression analysis, factors positively associated with procedural success were the use of Fielder XT guidewire(P = 0.005, 95%CI: 1.172-2.380) and systolic blood pressure(P = 0.011,95%CI: 1.003-1.022), while factors negatively associated with procedural success were blunt stump(P = 0.013, 95%CI: 1.341-11.862), male sex(P = 0.016, 95%CI:0.363-0.902), New York Heart Association(NYHA) class(P = 0.035, 95%CI: 0.553-0.979), contrast amount(P = 0.018, 95%CI: 0.983-0.998) and occlusion time(P =0.009, 95%CI: 0.994-0.999). No significant differences were found between the XT group and the no-XT group with respect to clinical parameters, lesion-related characteristics, coronary artery rupture [3(0.4%) vs 8(1.5%), P = 0.056], inhospital death [2(0.3%) vs 6(1.1%), P = 0.079] or in-hospital target lesion revascularization [3(0.4%) vs 7(1.3%), P < 0.099]. However, there were significant differences between the groups with respect to success rate [602(87.8%) vs 430(79.0%), P < 0.001], procedure time [(74 ± 23) vs(83 ± 21), P < 0.001], stent length[(32.0 ± 15.8) vs(37.3 ± 17.6), P < 0.001], contrast amount [(148 ± 46) vs(166 ± 43),P < 0.001], post-PCI myocardial infarction [43(6.3%) vs 59(10.8%), P = 0.004],major adverse cardiovascular event [44(6.4%) vs 57(10.7%), P = 0.007], side branch loss [31(4.5%) vs 44(8.1%), P = 0.009], contrast-induced nephropathy [29(4.2%) vs 40(7.4%), P = 0.018] and no reflow [8(1.2%) vs 14(2.9%), P = 0.034].CONCLUSION The use of Fielder XT guidewire shortens the Procedure and increases the success rate of CTO-PCI, and is also associated with reduced complication rates. 展开更多
关键词 Chronic total occlusion Percutaneous coronary intervention Anterograde wire escalation Parallel wire technique Fielder XT guidewire Success rate
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