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Enhancing regeneration and functionality of excitable tissues via integrating bioelectronics and bioengineered constructs 认领 引用 被引量：2
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作者 Zijie Meng Bingsong Gu +7 位作者 Cong Yao Jiaxin Li Kun Yu Yi Ding Pei He Nan Jiang Dichen Li Jiankang He 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2025年第2期121-169,共49页
The inherent complexities of excitable cardiac,nervous,and skeletal muscle tissues pose great challenges in constructing artificial counterparts that closely resemble their natural bioelectrical,structural,and mechani... The inherent complexities of excitable cardiac,nervous,and skeletal muscle tissues pose great challenges in constructing artificial counterparts that closely resemble their natural bioelectrical,structural,and mechanical properties.Recent advances have increasingly revealed the beneficial impact of bioelectrical microenvironments on cellular behaviors,tissue regeneration,and therapeutic efficacy for excitable tissues.This review aims to unveil the mechanisms by which electrical microenvironments enhance the regeneration and functionality of excitable cells and tissues,considering both endogenous electrical cues from electroactive biomaterials and exogenous electrical stimuli from external electronic systems.We explore the synergistic effects of these electrical microenvironments,combined with structural and mechanical guidance,on the regeneration of excitable tissues using tissue engineering scaffolds.Additionally,the emergence of microanoscale bioelectronics has significantly broadened this field,facilitating intimate interactions between implantable bioelectronics and excitable tissues across cellular,tissue,and organ levels.These interactions enable precise data acquisition and localized modulation of cell and tissue functionalities through intricately designed electronic components according to physiological needs.The integration of tissue engineering and bioelectronics promises optimal outcomes,highlighting a growing trend in developing living tissue construct-bioelectronic hybrids for restoring and monitoring damaged excitable tissues.Furthermore,we envision critical challenges in engineering the next-generation hybrids,focusing on integrated fabrication strategies,the development of ionic conductive biomaterials,and their convergence with biosensors. 展开更多
关键词 excitable tissue electrical microenvironment tissue engineering scaffold bioelectronic electrical stimulation tissue construct-bioelectronic hybrid
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The second near-infrared (NIR-II) window excitable/emissive organic/polymeric fluorescent molecules for bioimaging application 认领 引用 被引量：2
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作者 Guannan Liu Chenguang Wang Geyu Lu 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2025年第3期25-43,共19页
The fluorescence imaging (FLI) in the second near-infrared window (NIR-II, 1000–1700nm) has attracted considerable attention in the past decade. In contrast to conventional NIR-I window excitation (808nm/980nm), FLI ... The fluorescence imaging (FLI) in the second near-infrared window (NIR-II, 1000–1700nm) has attracted considerable attention in the past decade. In contrast to conventional NIR-I window excitation (808nm/980nm), FLI with NIR-II window excitation (1064nm/other wavelength beyond 1000nm) can afford deeper tissue penetration depth with high clarity due to the merits of suppressed photon scattering and diminished autofluorescence. In this review, we have summarized NIR-II window excitable/emissive organic/polymeric fluorophores recently developed. The characteristics of these fluorophores such as chemical structures and photophysical properties have also been critically discussed. Furthermore, the latest development of noninvasive in vivo FLI with NIR-II excitation was highlighted. The ideal imaging results emphasized the importance of NIR-II excitation of these fluorophores in enabling deep tissue penetration and high-resolution imaging. Finally, a perspective on the challenges and prospects of NIR-II excitable/emissive organic/polymeric fluorophores was also discussed. We expected this review will be served as a source of inspiration for researchers, stimulating the creation of novel NIR-II excitable fluorophores and fostering the development of bioimaging applications. 展开更多
关键词 Fluorescence imaging near-infrared excitation wavelength organic fluorophores conjugated polymers
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Network dynamics and its relationships to topology and coupling structure in excitable complex networks 认领 引用 被引量：7
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作者 张立升 谷伟凤 +1 位作者 胡岗 弭元元 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第10期626-632,共7页
All dynamic complex networks have two important aspects, pattern dynamics and network topology. Discovering different types of pattern dynamics and exploring how these dynamics depend oretwork topologies are tasks of ... All dynamic complex networks have two important aspects, pattern dynamics and network topology. Discovering different types of pattern dynamics and exploring how these dynamics depend oretwork topologies are tasks of both great theoretical importance and broad practical significance. In this paper we study the oscillatory behaviors of excitable complex networks （ECNs） and find some interesting dynamic behaviors of ECNs in oscillatory probability, the multiplicity of oscillatory attractors, period distribution, and different types of oscillatory patterns （e.g., periodic, quasiperiodic, and chaotic）. In these aspects, we further explore strikingly sharp differences among network dynamics induced by different topologies （random or scale-free topologies） and different interaction structures （symmetric or asymmetric couplings）. The mechanisms behind these differences are explained physically. 展开更多
关键词 excitable complex networks network topology symmetric and asymmetric couplings
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Synchronization of spiral waves in a two-layer coupled inhomogeneous excitable system 认领 引用 被引量：4
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作者 张国勇 马军 +1 位作者 俞连春 陈勇 《Chinese Physics B》 SCIE EI CAS 2008年第11期4107-4113,共7页
We studied synchronization behaviours of spiral waves in a two-layer coupled inhomogeneous excitable system. It was found that phase synchronization can be observed under weak coupling strength. By increasing the coup... We studied synchronization behaviours of spiral waves in a two-layer coupled inhomogeneous excitable system. It was found that phase synchronization can be observed under weak coupling strength. By increasing the coupling strength, the synchronization is broken down. With the further increase of the coupling strength, complete synchronization and phase synchronization occur again. We also found that the inhomogeneity in excitable systems is helpful to the synchronization. 展开更多
关键词 spiral waves synchronization inhomogeneous excitable media
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Cellular Automaton Simulations for Target Waves in Excitable Media 认领 引用 被引量：3
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作者 张立升 邓敏艺 +2 位作者 孔令江 刘慕仁 唐国宁 《Communications in Theoretical Physics》 SCIE CAS 2010年第1期171-174,共4页
Using the Greenberg-Hasting cellular automata model, we study the properties of target waves in excitable media under the no-flux boundary conditions. For the system has only one excited state, the computer simulation... Using the Greenberg-Hasting cellular automata model, we study the properties of target waves in excitable media under the no-flux boundary conditions. For the system has only one excited state, the computer simulation and analysis lead to the conclusions that, the number of refractory states does not influence the wave-front speed; the wave- front speed decreases as the excitation threshold increases and increases as the neighbor radius increases; the period of target waves is equal to the number of cell states; the excitation condition for target waves is that the wave-front speed must be bigger than half of the neighbor radius. 展开更多
关键词 cellular automata excitable media target wave
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Synchronized Firing in Coupled Inhomogeneous Excitable Neurons 认领 引用 被引量：2
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作者 ZHENG Zhi-Gang WANG Fu-Zhong 《Communications in Theoretical Physics》 SCIE CAS 2002年第10期415-420,共6页
We study the firing synchronization behavior of the inhomogeneous excitable media. Phase synchronizationof neuron firings is observed with increasing the coupling, while the phases of neurons are different (out-of-pha... We study the firing synchronization behavior of the inhomogeneous excitable media. Phase synchronizationof neuron firings is observed with increasing the coupling, while the phases of neurons are different (out-of-phase synchronization). We found the synchronization of bursts can be greatly enhanced by applying an external forcing (in-phasesynchronization). The external forcing can be either a periodic or just homogeneous thermal noise. The mechanismresponsible for this enhancement is discussed.PACS numbers: 05.45.-a, 87.10. 展开更多
关键词 excitable media, phase synchronization, FitzHugh-Nagumo model
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THE MOTION OF ORGANIZATION CENTER OF SCROLL WAVES IN EXCITABLE MEDIA WITH SINGLE DIFFUSION 认领 引用
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作者 刘深泉 陆启韶 黄克累 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1999年第4期79-86,共8页
The motion of organization center of three_dimensional untwisted scroll waves in excitable media with single diffusion is studied by singular perturbation method in this paper. The relation of curvature and the linear... The motion of organization center of three_dimensional untwisted scroll waves in excitable media with single diffusion is studied by singular perturbation method in this paper. The relation of curvature and the linear law are derived for untwisted organization center. These results have explicit physical meaning and are in good agreement with experiments. 展开更多
关键词 single diffusion scroll waves organization center vortex ring excitable media
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Feedback control of wave segments in an excitable medium 认领 引用
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作者 吴宁杰 高洪俊 应和平 《Chinese Physics B》 SCIE EI CAS CSCD 2013年第5期187-190,共4页
Depending on the excitability of the medium, a propagating wave segment will either contract or expand to fill the medium with spiral waves. This paper aims to introduce a simple mechanism of feedback control to stabi... Depending on the excitability of the medium, a propagating wave segment will either contract or expand to fill the medium with spiral waves. This paper aims to introduce a simple mechanism of feedback control to stabilize such an expansion or contraction. To do this, we lay out a feedback control system in a block diagram and reduce it into a bare, universal formula. Analytical and experimental findings are compared through a series of numerical simulations of the Barkley model. 展开更多
关键词 feedback control wave segments excitable medium
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STRUCTURE OF WAVE FRONT AND ORGANIZATION CENTER IN EXCITABLE MEDIA 认领 引用
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作者 刘深泉 LIUZeng-rong 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2004年第8期911-916,共6页
With help of establishing the moving coordinate on the wave front surface and the perturbation analysis in the boundary layer,the structures of wave front and organization center in excitable media were studied. The e... With help of establishing the moving coordinate on the wave front surface and the perturbation analysis in the boundary layer,the structures of wave front and organization center in excitable media were studied. The eikonal equation of wave front surface and general equation of organization center were obtained. These eikonal equations reveal the wave front surfaces have structures of twisted scroll wave and Mbius band, the organization centers have structures of knotted and linked ring. These theoretical results not only explain the wave patterns of BZ(Belousov-Zhabotinskii) chemical reaction but also give several possibility structures of wave front surface and organization center in general excitable media. 展开更多
关键词 excitable media wave front organization center
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Collective Dynamics for Network-Organized Identical Excitable Nodes 认领 引用 被引量：1
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作者 陶玉成 崔明珠 +1 位作者 李海红 杨俊忠 《Chinese Physics Letters》 SCIE EI CAS CSCD 2015年第2期23-26,共4页
We investigate the collective dynamics of network-organized identical excitable nodes. We theoretically analyze the stability of the rest state and propose that there are two different transition paths： the stationar... We investigate the collective dynamics of network-organized identical excitable nodes. We theoretically analyze the stability of the rest state and propose that there are two different transition paths： the stationary path and the oscillatory path. We find that, although the onset of collective dynamics strongly depend on the network topology, the local dynamics and how local nodes interact with each other decide the transition path and the involved bifurcation. 展开更多
关键词 net SFN ERN Collective Dynamics for Network-Organized Identical Excitable Nodes
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Neuronomodulation of Excitable Neurons 认领 引用 被引量：1
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作者 Yizhang Chen Lin Xiao Jian Qiu 《Neuroscience Bulletin》 SCIE CAS CSCD 2024年第1期103-112,共10页
Neuronomodulation refers to the modulation of neural conduction and synaptic transmission(i.e.,the conduction process involved in synaptic transmission)of excitable neurons via changes in the membrane potential in res... Neuronomodulation refers to the modulation of neural conduction and synaptic transmission(i.e.,the conduction process involved in synaptic transmission)of excitable neurons via changes in the membrane potential in response to chemical substances,from spillover neuro-transmitters to paracrine or endocrine hormones circulating in the blood.Neuronomodulation can be direct or indirect,depending on the transduction pathways from the ligand binding site to the ion pore,either on the same molecule,i.e.the ion channel,or through an intermediate step on different molecules.The major players in direct neurono-modulation are ligand-gated or voltage-gated ion channels.The key process of direct neuronomodulation is the binding and chemoactivation of ligand-gated or voltage-gated ion channels,either orthosterically or allosterically,by various ligands.Indirect neuronomodulation involves metabotropic receptor-mediated slow potentials,where steroid hormones,cytokines,and chemokines can implement these actions.Elucidating neuronomodulation is of great significance for understanding the physiological mechanisms of brain function,and the occurrence and treatment of diseases. 展开更多
关键词 Neuron Membrane potential Excitability Chemoactivation Neuronomodulation
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Improved functional-weight approach to oscillatory patterns in excitable networks 认领 引用
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作者 Tao Li Lin Yan Zhigang Zheng 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第9期225-233,共9页
Studies of sustained oscillations on complex networks with excitable node dynamics received much interest in recent years.Although an individual unit is non-oscillatory,they may organize to form various collective osc... Studies of sustained oscillations on complex networks with excitable node dynamics received much interest in recent years.Although an individual unit is non-oscillatory,they may organize to form various collective oscillatory patterns through networked connections.An excitable network usually possesses a number of oscillatory modes dominated by different Winfree loops and numerous spatiotemporal patterns organized by different propagation path distributions.The traditional approach of the so-called dominant phase-advanced drive method has been well applied to the study of stationary oscillation patterns on a network.In this paper,we develop the functional-weight approach that has been successfully used in studies of sustained oscillations in gene-regulated networks by an extension to the high-dimensional node dynamics.This approach can be well applied to the study of sustained oscillations in coupled excitable units.We tested this scheme for different networks,such as homogeneous random networks,small-world networks,and scale-free networks and found it can accurately dig out the oscillation source and the propagation path.The present approach is believed to have the potential in studies competitive non-stationary dynamics. 展开更多
关键词 self-sustained osillation excitable network functional-weight approach
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Enhanced Near-Infrared-Excitable Organic Afterglow Nanoparticles for Deep-Tissue Multimodal Imaging via Singlet Oxygen-Mediated Energy Transfer 认领 引用 被引量：1
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作者 Yuzhen Yu Zhe Li +6 位作者 Shiyi Liao Baoli Yin Qingpeng Zhang Jiaqi Fu Cheng Zhang Ying Zhou Guosheng Song 《Research》 SCIE EI CSCD 2026年第3期409-418,共10页
Afterglow imaging offers exceptional signal-to-background ratios(SBRs)by circumventing real-time excitation and autofluorescence,yet conventional systems rely on visible-light excitation,limiting tissue penetration an... Afterglow imaging offers exceptional signal-to-background ratios(SBRs)by circumventing real-time excitation and autofluorescence,yet conventional systems rely on visible-light excitation,limiting tissue penetration and signal intensity.Here,we report near-infrared-excitable organic afterglow nanoparticles(NOANPs)that leverage singlet oxygen(1O2)-mediated energy transfer to achieve prolonged,high-intensity emission with minimal photobleaching.The nanoparticles integrate a nearinfrared-photoactive sensitizer(NAM-0),which generates abundant 1O2 under 808-nm laser excitation,and a triplenet-anthracene derivative(TD)as the afterglow substrate,which converts 1O2 into sustained luminescence.Co-encapsulation via one-step nanocoprecipitation ensures proximity between NAM-0 and TD,enabling efficient energy transfer and yielding exceptional afterglow brightness(>109 photons/s)at ultralow concentrations(10μg/ml).NOANPs enable deep-tissue imaging(up to 3.0 cm ex vivo)by synergizing the superior penetration of near-infrared light with organic afterglow chemistry.The nanoparticles uniquely support three imaging modes:fluorescence,white light-activated afterglow,and near-infrared-triggered afterglow,which were validated in orthotopic murine models of pancreatic cancer and glioma.By synergizing near-infrared excitation with organic afterglow chemistry,this work overcomes longstanding limitations in penetration depth of excitation light,offering a versatile tool for precision imaging. 展开更多
关键词 organic afterglow nanoparticles noanps Near Infrared Photoactive Sensitizer Photobleaching Deep Tissue Multimodal Imaging afterglow imaging singlet oxygen o mediated Signal Background Ratios Near Infrared Excitable Organic Afterglow Nanoparticles
Far-red-excitable ultra-long-lived organic photocatalyst for photocatalytic decaging 认领 引用
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作者 Ying-Ze Li Wen-Yue Lin +10 位作者 Jia-Yao Li Zhi-Zhuo Zhang Qing-Hua Gao Ming-Yu Zhang Lin-Han Jiang Dong-Xue Guo Yi Peng Hong-Juan Feng Zhi Huang Chuan-Cheng Jia Ling Huang 《Science China Chemistry》 SCIE EI CAS CSCD 2026年第2期1023-1030,共8页
Photomodulation technology,characterized by its high spatiotemporal resolution,has emerged as a transformative approach for precise,rapid,and noninvasive regulation of intricate cellular signaling networks,offering un... Photomodulation technology,characterized by its high spatiotemporal resolution,has emerged as a transformative approach for precise,rapid,and noninvasive regulation of intricate cellular signaling networks,offering unprecedented opportunities for biomedical research.Nevertheless,the in vivo implementation of wireless photomodulation remains constrained by the inherent limitations of conventional photoresponsive systems.Addressing this challenge,we report a BODIPY-based photocatalyst with exceptional red-light responsiveness(λ>630 nm).Transient spectroscopic studies show that this photocatalyst exhibits the feature with solvent polarity-switching excited state dynamics.In addition,we observed ultralong triplet-state lifetimes(590μs in tetrahydrofuran;862μs in toluene),which is favorable for establishing a far-red-light-driven photocatalytic decaging platform that synergistically integrates the BODIPY photocatalyst with endogenous NADH as the intrinsic electron donor.Crucially,this system demonstrates robust in vivo efficacy,achieving significant tumor growth suppression in murine tumor models through localized prodrug activation.This work not only provides fundamental insights into engineering long-lived triplet states in metal-free organic photocatalysts but also pioneers a biocompatible strategy for spatiotemporally controlled therapeutic interventions,bridging the gap between advanced photochemistry and precision biomedicine. 展开更多
关键词 organic photocatalyst photocatalytic decaging ultra-long-lived excited state dynamics charge transfer state
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An NIR-Ⅲ 3P Excitable AIE Nanoprobe for High-Quality Intravital Deep-Brain Angiography 认领 引用 被引量：3
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作者 Zhijun Zhang Hui Cheng +6 位作者 Zengming Yang Xiangquan Deng Miaomiao Kang Ping Qiu Ke Wang Dong Wang Ben Zhong Tang 《Aggregate》 EI CAS CSCD 2025年第7期147-156,共10页
Three-photon(3P)fluorescence imaging(FLI)utilizing excitation wavelengths within the near-infrared-Ⅲ (NIR-Ⅲ,1600-1870 nm)window has emerged as a transformative modality for intravital imaging,owing to its combined a... Three-photon(3P)fluorescence imaging(FLI)utilizing excitation wavelengths within the near-infrared-Ⅲ (NIR-Ⅲ,1600-1870 nm)window has emerged as a transformative modality for intravital imaging,owing to its combined advantages of excellent spatiotemporal resolution and remarkable tissue penetration.High-performance fluorescent probes are the cornerstone of highquality NIR-Ⅲ3P FLI.However,the construction of such probes is often hindered by inherent trade-offs in molecular design principles,posing significant challenges for their performance optimization and practical application.Here,we propose a straightforward and effective strategy based onπ-bridge manipulation to reconcile those competing molecular design parameters and substantially enhance 3P fluorescence properties.Leveraging this approach,a robust AIE-active small molecule,named TSSID,was developed,which exhibits bright NIR-I(700-950 nm)emission under 1665 nm NIR-Ⅲ3P excitation when formulated into nanoparticles(NPs).Remarkably,upon retro-orbital injection into mice following craniotomy,TSSID NPs achieved the best performance in deep-brain angiography among all reported organic 3P materials in terms of vascular imaging depth,signalto-background ratio,spatial resolution,and hemodynamic imaging depth.Additionally,TSSID NPs demonstrated outstanding biocompatibility through systematic biosafety evaluations.This study provides an excellent imaging agent and useful molecular design philosophy,facilitating the development of advanced organic 3P FLI probes. 展开更多
关键词 aggregation-induced emission intravital deep-brain angiography molecular engineering NIR-Ⅰfluorescence emission NIR-Ⅲthree-photon excitation
Efficient violet-light-excitable blue-cyan phosphor for full-spectrum lighting 认领 引用 被引量：6
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作者 Yuhe Shao Hao Cai +3 位作者 Fangyi Zhao Shengqiang Liu Zhen Song Quanlin Liu 《Inorganic Chemistry Frontiers》 SCIE EI 2022年第21期5590-5596,共7页
In order to realize full-spectrum lighting,excellent blue-cyan phosphors,which can be excited by violet LED chips,are particularly important to compensate for the spectral cyan gap.Herein,we report an efficient and th... In order to realize full-spectrum lighting,excellent blue-cyan phosphors,which can be excited by violet LED chips,are particularly important to compensate for the spectral cyan gap.Herein,we report an efficient and thermally stable Eu2+-doped T-phase blue-cyan phosphor,Ba1.305Ca0.38Mg0.3SiO4:0.015Eu2+(BCM0.3S:Eu2+)through structure design and composition optimization.The emission spectrum presents an asymmetric band peaking at 475 nm with a small Stokes shift under 400 nm excitation.The internal/external quantum efficiencies of this phosphor are up to 82.9%/66.2%,and the integrated emission intensity at 150℃ is maintained at 90% of that at room temperature.Due to the compensation of the blue-cyan gap,the fabricated white lightemitting diode(pc-WLED),made of BCM0.3S:Eu2+combined with the 400 nm chip and other phosphors,shows an ultra-high color rendering index(Ra=95.7).These prominent properties give BCM0.3S:Eu2+potential applications in the field of full-spectrum healthy lighting. 展开更多
关键词 violet light excitable structure design composition optimizationthe violet led chipsare asymmetric band stokes shift emission spectrum compensate spectral cyan gaphereinwe
Firing rates of coupled noisy excitable elements 认领 引用 被引量：4
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作者 Shuai Liu Zhi-Wei He Meng Zhan 《Frontiers of physics》 SCIE CSCD 2014年第1期120-127,共8页
The dynamics of coupled excitable FitzHugh Nagumo systems under external noisy driving is studied. Different from most of previous work focusing on the noise-induced regularity in the framework of coherence resonance,... The dynamics of coupled excitable FitzHugh Nagumo systems under external noisy driving is studied. Different from most of previous work focusing on the noise-induced regularity in the framework of coherence resonance, here the average frequency （or firing rate） of coupled excitable elements is of much more concern. We find that （i） their frequencies first increase and then decrease with the increase of the coupling, and there is a clear crossover from a rush increase to a smooth increase with the increase of noise strength, and （ii） for nonidentical cases, all elements transit to an identical frequency simultaneously only after a certain coupling strength is achieved. These first-increase-thendecrease non-monotonic frequency behavior and isochronous frequency synchronization are believed to be two basic behaviors in coupled noisy excitable systems. 展开更多
关键词 coupled excitable elements firing rate noise coherence resonance
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Excitation direction and intensity-dependent damping performance of a nonlinear energy sink:theory and experiments 认领 引用
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作者 Xiaofeng GENG Shican LIU +4 位作者 Li ZHANG Kexiang WEI Yingan KANG Xingjian JING Hu DING 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2026年第7期1433-1446,共14页
The traditional nonlinear energy sink(NES)exhibits high robustness over a wide frequency interval under unidirectional excitation.However,variable excitation directions and intensities are common in engineering applic... The traditional nonlinear energy sink(NES)exhibits high robustness over a wide frequency interval under unidirectional excitation.However,variable excitation directions and intensities are common in engineering applications,and the vibration reduction performance of the conventional NES remains uncertain.In this paper,a dynamic model of a linear oscillator(LO)equipped with an NES is established to investigate the effects of the excitation direction and intensity on the NES performance.Moreover,a three-dimensional model is designed,and a corresponding experimental platform is constructed.The vibration reduction performance of a conventional NES is theoretically investigated under variable excitation directions and intensities.Moreover,the dynamic characteristics are revealed for both free and forced vibrations.Experimental tests are conducted to validate the prediction results.This study demonstrates that the vibration suppression performance of the NES is highly sensitive to both the excitation direction and intensity.Overall,although the performance of the NES decreases with increasing excitation angle,vibration can be effectively suppressed over a wide angle range.This finding indicates that the traditional NES is highly robust to the excitation direction.In addition,the NES exhibits notable damping performance within a wide excitation range,especially at high excitation angles.For relatively low and very high excitation intensities,the performance of the NES is poor.The vibration reduction trend under the coupling effect of the excitation intensity and direction is systematically revealed.A critical excitation intensity is identified,at which the NES exhibits weaker performance at low angles but enhanced performance at high angles.The findings provide a theoretical basis for promoting NES engineering applications. 展开更多
关键词 nonlinear energy sink(NES) excitation direction excitation intensity passive suppression vibration reduction efficiency
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Beyond the bench:Evaluating the reliability of chemical scavengers in radical-based advanced oxidation processes 认领 引用
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作者 Ruiyang Xiao Zonghao Luo +5 位作者 Zongsu Wei Daisuke Minakata Richard Spinney Stanislaw Waclawek Weizhi Zeng Chongjian Tang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第5期608-613,共6页
Chemical scavengers are frequently used to quantify the contribution of target radicals to contaminant removal in natural and engineered waters.While favored for their ease of use and versatility across systems,improp... Chemical scavengers are frequently used to quantify the contribution of target radicals to contaminant removal in natural and engineered waters.While favored for their ease of use and versatility across systems,improper selection can lead to significant kinetic and mechanistic misinterpretations.This study presents a critical evaluation of chemical scavengers in radical-induced reactions across various environmental scenarios.Specifically,we demonstrate that in systems containing both target and coexisting radicals,commonly used scavengers can react with both species,complicating the measurement of reaction kinetics and leading to misinterpretation of target radical contributions.In addition,we discuss the challenges associated with applying scavengers in heterogeneous systems,where the distribution of scavengers and target compounds across interfaces significantly impacts the evaluation of radical contributions.Further,our insights from non-steady-state systems into radicals'dynamic behavior and transient phenomena are often overlooked in other steady-state conditions.We address interactions between scavengers and triplet excited-state compounds in photochemical systems,emphasizing the importance of selecting appropriate scavengers to ensure accurate kinetic profiling and radical quantification.These findings hold significant implications for advancing scavenger research across a broad range of chemical research and practical applications. 展开更多
关键词 Chemical scavenger Radical contribution Kinetic misinterpretation Heterogeneous system Triplet excited state
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Epilepsy therapy beyond neurons: Unveiling astrocytes as cellular targets 认领 引用
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作者 Yuncan Chen Jiayi Hu +5 位作者 Ying Zhang Lulu Peng Xiaoyu Li Cong Li Xunyi Wu Cong Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期23-38,共16页
Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the ... Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the urgent need to explore new treatment strategies for epilepsy, recent research has highlighted the potential of targeting gliosis, metabolic disturbances, and neural circuit abnormalities as therapeutic strategies. Astrocytes, the largest group of nonneuronal cells in the central nervous system, play several crucial roles in maintaining ionic and energy metabolic homeostasis in neurons, regulating neurotransmitter levels, and modulating synaptic plasticity. This article briefly reviews the critical role of astrocytes in maintaining balance within the central nervous system. Building on previous research, we discuss how astrocyte dysfunction contributes to the onset and progression of epilepsy through four key aspects: the imbalance between excitatory and inhibitory neuronal signaling, dysregulation of metabolic homeostasis in the neuronal microenvironment, neuroinflammation, and the formation of abnormal neural circuits. We summarize relevant basic research conducted over the past 5 years that has focused on modulating astrocytes as a therapeutic approach for epilepsy. We categorize the therapeutic targets proposed by these studies into four areas: restoration of the excitation–inhibition balance, reestablishment of metabolic homeostasis, modulation of immune and inflammatory responses, and reconstruction of abnormal neural circuits. These targets correspond to the pathophysiological mechanisms by which astrocytes contribute to epilepsy. Additionally, we need to consider the potential challenges and limitations of translating these identified therapeutic targets into clinical treatments. These limitations arise from interspecies differences between humans and animal models, as well as the complex comorbidities associated with epilepsy in humans. We also highlight valuable future research directions worth exploring in the treatment of epilepsy and the regulation of astrocytes, such as gene therapy and imaging strategies. The findings presented in this review may help open new therapeutic avenues for patients with drugresistant epilepsy and for those suffering from other central nervous system disorders associated with astrocytic dysfunction. 展开更多
关键词 astrocyte cellular microenvironment drug resistance epilepsy excitability homeostasis metabolism neural networks neuroinflammation neuron
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