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Bayesian Factorized Cointegration Analysis 认领 引用
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作者 Kai Cui Wenshan Cui 《Open Journal of Statistics》 2012年第5期504-511,共8页
The concept of cointegration is widely used in applied non-stationary time series analysis to describe the co-movement of data measured over time. In this paper, we proposed a Bayesian model for cointegration test and... The concept of cointegration is widely used in applied non-stationary time series analysis to describe the co-movement of data measured over time. In this paper, we proposed a Bayesian model for cointegration test and analysis, based on the dynamic latent factor framework. Efficient computational algorithms are also developed based on Markov Chain Monte Carlo (MCMC). Performance and efficiency of the the model and approaches are assessed by simulated and real data analysis. 展开更多
关键词 Cointegration Bayesian Dynamic Factor Non-Stationary Root Structure MCMC
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Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury 认领 引用 被引量：4
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作者 Fanzhuo Zeng Yuxin Li +6 位作者 Xiaoyu Li Xinyang Gu Yue Cao Shuai Cheng He Tian Rongcheng Mei Xifan Mei 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期365-376,共12页
Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in s... Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in spinal cord injury.Previous studies have shown that microglia can promote neuronal survival by phagocytosing dead cells and debris and by releasing neuroprotective and anti-inflammatory factors.However,excessive activation of microglia can lead to persistent inflammation and contribute to the formation of glial scars,which hinder axonal regeneration.Despite this,the precise role and mechanisms of microglia during the acute phase of spinal cord injury remain controversial and poorly understood.To elucidate the role of microglia in spinal cord injury,we employed the colony-stimulating factor 1 receptor inhibitor PLX5622 to deplete microglia.We observed that sustained depletion of microglia resulted in an expansion of the lesion area,downregulation of brain-derived neurotrophic factor,and impaired functional recovery after spinal cord injury.Next,we generated a transgenic mouse line with conditional overexpression of brain-derived neurotrophic factor specifically in microglia.We found that brain-derived neurotrophic factor overexpression in microglia increased angiogenesis and blood flow following spinal cord injury and facilitated the recovery of hindlimb motor function.Additionally,brain-derived neurotrophic factor overexpression in microglia reduced inflammation and neuronal apoptosis during the acute phase of spinal cord injury.Furthermore,through using specific transgenic mouse lines,TMEM119,and the colony-stimulating factor 1 receptor inhibitor PLX73086,we demonstrated that the neuroprotective effects were predominantly due to brain-derived neurotrophic factor overexpression in microglia rather than macrophages.In conclusion,our findings suggest the critical role of microglia in the formation of protective glial scars.Depleting microglia is detrimental to recovery of spinal cord injury,whereas targeting brain-derived neurotrophic factor overexpression in microglia represents a promising and novel therapeutic strategy to enhance motor function recovery in patients with spinal cord injury. 展开更多
关键词 angiogenesis apoptosis brain-derived neurotrophic factor colony stimulating factor 1 receptor inflammation microglia motor function spinal cord injury vascular endothelial growth factor
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Organelle symphony:Nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B in stroke pathobiology 认领 引用 被引量：2
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作者 Ziliang Hu Mingyue Zhao +4 位作者 Hangyu Shen Liangzhe Wei Jie Sun Xiang Gao Yi Huang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第4期1483-1496,共14页
Strokes include both ischemic stroke,which is mediated by a blockade or reduction in the blood supply to the brain,and hemorrhagic stroke,which comprises intracerebral hemorrhage and subarachnoid hemorrhage and is cha... Strokes include both ischemic stroke,which is mediated by a blockade or reduction in the blood supply to the brain,and hemorrhagic stroke,which comprises intracerebral hemorrhage and subarachnoid hemorrhage and is characterized by bleeding within the brain.Stroke is a lifethreatening cerebrovascular condition characterized by intricate pathophysiological mechanisms,including oxidative stress,inflammation,mitochondrial dysfunction,and neuronal injury.Critical transcription factors,such as nuclear factor erythroid 2-related factor 2 and nuclear factor kappa B,play central roles in the progression of stroke.Nuclear factor erythroid 2-related factor 2 is sensitive to changes in the cellular redox status and is crucial in protecting cells against oxidative damage,inflammatory responses,and cytotoxic agents.It plays a significant role in post-stroke neuroprotection and repair by influencing mitochondrial function,endoplasmic reticulum stress,and lysosomal activity and regulating metabolic pathways and cytokine expression.Conversely,nuclear factor-kappa B is closely associated with mitochondrial dysfunction,the generation of reactive oxygen species,oxidative stress exacerbation,and inflammation.Nuclear factor-kappa B contributes to neuronal injury,apoptosis,and immune responses following stroke by modulating cell adhesion molecules and inflammatory mediators.The interplay between these pathways,potentially involving crosstalk among various organelles,significantly influences stroke pathophysiology.Advancements in single-cell sequencing and spatial transcriptomics have greatly improved our understanding of stroke pathogenesis and offer new opportunities for the development of targeted,individualized,cell typespecific treatments.In this review,we discuss the mechanisms underlying the involvement of nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B in both ischemic and hemorrhagic stroke,with an emphasis on their roles in oxidative stress,inflammation,and neuroprotection. 展开更多
关键词 inflammation nuclear factor erythroid 2-related factor 2 nuclear factor-kappa B organelles oxidative stress stroke
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TGF-β/BMP signaling in skeletal biology:molecular mechanisms,regulatory networks,and therapeutic implications in development,regeneration,and disease 认领 引用 被引量：4
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作者 Junguang Liao Taofen Wu +9 位作者 Qi Zhang Panpan Shen Ziyi Huang Jiaqi Wang Pengxiang Zhang Sisi Lin Jiashun Pi Nenghua Zhang Haidong Wang Guiqian Chen 《Bone Research》 SCIE CAS CSCD 2026年第1期109-140,共32页
The transforming growth factor-β(TGF-β)and bone morphogenetic protein(BMP)signaling pathways are pivotal regulators of cellular processes,playing indispensable roles in embryogenesis,postnatal development,and tissue... The transforming growth factor-β(TGF-β)and bone morphogenetic protein(BMP)signaling pathways are pivotal regulators of cellular processes,playing indispensable roles in embryogenesis,postnatal development,and tissue homeostasis.These pathways are particularly critical within the skeletal system,as they coordinate osteogenesis,chondrogenesis,and bone remodeling through intricate molecular mechanisms.TGF-β/BMP signaling is primarily transduced via canonical Smad-dependent pathways(e.g.,ligands,receptors,and intracellular Smads)and the non-canonical Smad-independent(e.g.,p38 mitogen-activated protein kinase,MAPK)cascade.Both pathways converge on master transcriptional regulators,including Runx2 and Osterix,and their precise coordination is indispensable for skeletal development,maintenance,and repair.The dysregulation of TGF-β/BMP signaling contributes to a spectrum of skeletal dysplasia and bone pathologies.Advances in molecular genetics,particularly gene-targeting strategies and transgenic mouse models,have deepened our understanding of the spatiotemporal control of TGF-β/BMP signaling in bone and cartilage development.Moreover,emerging research underscores extensive crosstalk between TGF-β/BMP and other critical pathways,such as Wnt/β-catenin,mitogen-activated protein kinase(MAPK),parathyroid hormone(PTH)/PTH-related protein(PTHrP),fibroblast growth factors(FGF),Hedgehog,Notch,insulin-like growth factors(IGF)/insulin-like growth factors receptor(IGFR),Mammalian target of rapamycin(mTOR),and autophagy,forming an integrated regulatory network that ensures skeletal integrity.Our review synthesizes the current knowledge on the molecular components,regulatory mechanisms,and functional integration of TGF-β/BMP signaling in skeletal biology,with an emphasis on its roles in development,regeneration,and disease.By elucidating the molecular underpinnings of TGF-β/BMP pathways and their contextual interactions,we aim to highlight translational opportunities and novel therapeutic strategies for treating skeletal disorders. 展开更多
关键词 transforming growth factor molecular mechanismstgf bmp tissue homeostasisthese bone remodeling skeletal systemas skeletal biology molecular mechanisms bone morphogenetic
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Temperature determines the biomass of forest floor bryophytes:A cross-regional investigation in 413 sites 认领 引用 被引量：2
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作者 Zhe Wang Defeng Feng +4 位作者 Yanqiang Jin Mijun Zou Beibei Gao Xin Liu Weikai Bao 《Forest Ecosystems》 SCIE CAS CSCD 2026年第1期212-219,共8页
Understory bryophytes play unique and disproportionately important roles in water retention,biogeochemical cycling,and biodiversity conservation,and serve as bioindicators of environmental health in forest ecosystems.... Understory bryophytes play unique and disproportionately important roles in water retention,biogeochemical cycling,and biodiversity conservation,and serve as bioindicators of environmental health in forest ecosystems.However,biogeographical research on the biomass of forest bryophytes is inadequately studied and has been limited to elevational gradients.We conducted a systematic cross-regional survey of bryophyte biomass across 413 forest sites in Sichuan Province,China.We analyzed how each environmental variable,including climatic and atmospheric factors,overstory covers,and soil nutrients,relates to bryophyte biomass and quantified their relative contributions.The results indicate that,largely similar to previous local investigations and experiments,at a large scale,bryophytes are abundant in forests with lower temperature,nitrogen deposition,vapor pressure deficit,and tree and herb covers,as well as higher light availability.Moreover,bryophyte biomass is positively associated with soil carbon and nitrogen content.These environmental variables are closely related and jointly influence bryophyte biomass,with mean annual temperature being the most significant factor(accounting for 83%of the relative contribution).The biogeographical patterns of bryophyte biomass contribute to deepening our understanding of their adaptations to multiple environmental variables and enable us to predict their responses to global climate change.These patterns also provide essential evidence for establishing more accurate terrestrial vegetation ecosystem models. 展开更多
关键词 Biogeography Environmental factor Nonvascular photoautotrophs Phytomass Relative contribution
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Enhanced neurogenesis after ischemic stroke:The interplay between endogenous and exogenous stem cells 认领 引用 被引量：3
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作者 Ruxu Geng Yuhe Wang +2 位作者 Renzhi Wang Jun Wu Xinjie Bao 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期212-223,共12页
Ischemic stroke is a significant global health crisis,frequently resulting in disability or death,with limited therapeutic interventions available.Although various intrinsic reparative processes are initiated within t... Ischemic stroke is a significant global health crisis,frequently resulting in disability or death,with limited therapeutic interventions available.Although various intrinsic reparative processes are initiated within the ischemic brain,these mechanisms are often insufficient to restore neuronal functionality.This has led to intensive investigation into the use of exogenous stem cells as a potential therapeutic option.This comprehensive review outlines the ontogeny and mechanisms of activation of endogenous neural stem cells within the adult brain following ischemic events,with focus on the impact of stem cell-based therapies on neural stem cells.Exogenous stem cells have been shown to enhance the proliferation of endogenous neural stem cells via direct cell-tocell contact and through the secretion of growth factors and exosomes.Additionally,implanted stem cells may recruit host stem cells from their niches to the infarct area by establishing so-called“biobridges.”Furthermore,xenogeneic and allogeneic stem cells can modify the microenvironment of the infarcted brain tissue through immunomodulatory and angiogenic effects,thereby supporting endogenous neuroregeneration.Given the convergence of regulatory pathways between exogenous and endogenous stem cells and the necessity for a supportive microenvironment,we discuss three strategies to simultaneously enhance the therapeutic efficacy of both cell types.These approaches include:(1)co-administration of various growth factors and pharmacological agents alongside stem cell transplantation to reduce stem cell apoptosis;(2)synergistic administration of stem cells and their exosomes to amplify paracrine effects;and(3)integration of stem cells within hydrogels,which provide a protective scaffold for the implanted cells while facilitating the regeneration of neural tissue and the reconstitution of neural circuits.This comprehensive review highlights the interactions and shared regulatory mechanisms between endogenous neural stem cells and exogenously implanted stem cells and may offer new insights for improving the efficacy of stem cell-based therapies in the treatment of ischemic stroke. 展开更多
关键词 brain-derived neurotrophic factor endogenous neuroregeneration exosomes hydrogels ischemic stroke mesenchymal stem cells neural stem cells neurogenesis stem cell transplantation
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CpMYB114-like enhances CpNADP-ME2 expression to induce malate reduction and sugar accumulation during papaya ripening 认领 引用 被引量：2
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作者 Chenping Zhou Ruibin Kuang +5 位作者 Xiaming Wu Ze Xu Han He Chuanhe Liu Yuerong Wei Min Yang 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第8期1810-1826,共17页
Sugars and organic acids form the core fundamental flavor foundation of ripe papaya fruit.Although R2R3-type v-myb myeloblastosis viral oncogene homolog transcription factors(R2R3-MYB TFs)have been reported to play im... Sugars and organic acids form the core fundamental flavor foundation of ripe papaya fruit.Although R2R3-type v-myb myeloblastosis viral oncogene homolog transcription factors(R2R3-MYB TFs)have been reported to play important roles in regulating the primary and secondary metabolism in fruits.However,the functions and underlying regulatory mechanisms of R2R3-MYB TFs in the metabolism of sugars and organic acids during papaya ripening remain unclear.In this study,through RNA sequencing(RNA-seq)coupled with quantitative real-time polymerase chain reaction(qRT-PCR)validation,a novel ethylene-responsive R2R3-MYB TF gene,CpMYB114-like(CpMYB114L),was identified.Transcriptome analysis and ethylene induction assays highlighted CpMYB114L as the key MYB gene activated during papaya ripening.Subcellular localization experiments confirmed that CpMYB114L was localized in the nucleus.Analyses of transgenic papaya fruits and calli,demonstrated that CpMYB114L promoted the accumulation of glucose,fructose,and sucrose,while simultaneously accelerating malate degradation.DNA Affinity Purification sequencing(DAP-seq)combined with yeast one-hybrid(Y1H)assays identified that CpMYB114L directly bound to the promoters of two sugar/organic acid metabolism-related genes,Isocitrate dehydrogenase 5(CpIDH5)and NADP-dependent malic enzyme 2(CpNADP-ME2).Electrophoretic mobility shift(EMSA),dual-luciferase reporter(Dual-LUC)and chromatin immunoprecipitation-quantitative PCR(ChIP-qPCR)assays further confirmed that CpMYB114L positively activated the expression of CpIDH5 and CpNADP-ME2 by directly binding to the specific regions of their promoters.Notably,transient overexpression of CpNADP-ME2 in papaya fruits and calli recapitulated decreased malate levels and increased sugar content,whereas CpIDH5 overexpression did not exhibit any functional relevance.This study elucidates a regulatory module,CpMYB114L-CpNADP-ME2,linking malate catabolism and sugar accumulation,offering valuable insights into flavor improvement strategies for papaya. 展开更多
关键词 Carica papaya Differentially expressed genes Ethylene Fruit quality Malic enzyme MYB transcription factor
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Changes in border-associated macrophages after stroke: Single-cell sequencing analysis 认领 引用 被引量：2
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作者 Ning Yu Yang Zhao +3 位作者 Peng Wang Fuqiang Zhang Cuili Wen Shilei Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期346-356,共11页
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro... Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment. 展开更多
关键词 border-associated macrophages clodronate hypoxia ischemia-reperfusion ischemic stroke liposomes neuroinflammation single-cell sequencing analysis STAT3 tumor necrosis factor
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Variations and major driving factors for soil nutrients in a typical karst region in Southwest China 认领 引用 被引量：2
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作者 Miaomiao Wang Hongsong Chen +1 位作者 Wei Zhang Kelin Wang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第2期424-435,共12页
Understanding the spatial distributions and corresponding variation mechanisms of key soil nutrients in fragile karst ecosystems can assist in promoting sustainable development.However,due to the implementation of eco... Understanding the spatial distributions and corresponding variation mechanisms of key soil nutrients in fragile karst ecosystems can assist in promoting sustainable development.However,due to the implementation of ecological restoration initiatives such as land-use conversions,novel changes in the spatial characteristics of soil nutrients remain unknown.To address this gap,we explored nutrient variations and the drivers of the variation in the 0–15 cm topsoil layer using a regional-scale sampling method in a typical karst area in northwest Guangxi Zhuang Autonomous Region,Southwest China.Descriptive statistics,geostatistics,and spatial analysis were used to assess the soil nutrient variability.The results indicated that soil organic carbon(SOC),total nitrogen(TN),total phosphorus(TP),and total potassium(TK)concentrations showed moderate variations,with coefficients of variance being 0.60,0.60,0.71,and 0.72,respectively.Moreover,they demonstrated positive spatial autocorrelations,with global Moran's indices being 0.68,0.77,0.64,and 0.68,respectively.However,local Moran's index values were low,indicating large spatial variations in soil nutrients.The best-fitting semi-variogram models for SOC,TN,TP,and TK concentrations were spherical,Gaussian,exponential,and exponential,respectively.According to the classification criteria of the Second National Soil Census in China,SOC and TN concentrations were relatively sufficient,with the proportions of rich and very rich levels being up to 90.9 and 96.0%,respectively.TP concentration was in the mediumdeficient level,with the areas of medium and deficient levels accounting for 33.7 and 30.1%of the total,respectively.TK concentration was deficient,with the cumulative area of extremely deficient,very deficient,and deficient levels accounting for 87.6%of the total area.Consequently,the terrestrial ecosystems in the study area were more vulnerable to soil P and K than soil N deficiencies.Furthermore,variance partitioning analysis of the influencing factors showed that,except for the interactions,the single effect of other soil properties accounted more for soil nutrient variations than spatial and environmental variables.These results will aid in the future management of terrestrial ecosystems. 展开更多
关键词 dominant factor geostatistics karst ecosystem soil nutrient classification spatial variation
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Gallbladder carcinoma in Brazil: Clinicopathological profile and survival outcomes from a high-volume cancer center 认领 引用 被引量：2
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作者 Fabio Ferrari Makdissi Lucas Eiki Kawakami +5 位作者 Marina Alessandra Pereira Jaime Arthur Pirola Kruguer Gilton Fonseca Marques Fabricio Ferreira Coelho Jose Jukemura Paulo Herman 《World Journal of Gastroenterology》 SCIE CAS 2026年第7期50-62,共13页
BACKGROUND Gallbladder cancer(GBC)is the most prevalent malignant tumor of the biliary tract and remains associated with poor survival outcomes due to its aggressive biological behavior and typically late diagnosis.Re... BACKGROUND Gallbladder cancer(GBC)is the most prevalent malignant tumor of the biliary tract and remains associated with poor survival outcomes due to its aggressive biological behavior and typically late diagnosis.Regional differences in incidence and outcomes emphasize the need for country-specific data.In Brazil such information remains scarce.AIM To evaluate the clinicopathological characteristics,therapeutic approaches,and survival outcomes of patients with GBC treated at a high-volume cancer center in Brazil.METHODS This retrospective study analyzed 364 patients with histologically confirmed gallbladder adenocarcinoma treated at a high-volume Brazilian cancer center from 2010 to 2024.Clinical,pathological,and treatment-related variables were analyzed.Patients were stratified into incidental GBC(IGBC)and non-IGBC groups.RESULTS The cohort was predominantly female(78.8%)with a mean age of 62.1 years.Most patients(72.3%)presented with stage IV disease.IGBC accounted for 54.1%of cases and showed significantly improved survival compared with non-IGBC[median overall survival(OS):18 months vs 7 months;P2;hazard ratio(HR)=1.91],advanced T stage(T3:HR=4.38;T4:HR=5.24),metastasis(M1;HR=2.76),and non-IGBC diagnosis(HR=1.35).CONCLUSION GBC in Brazil commonly presents at advanced stages,restricting curative options.IGBC is more prevalent and has better outcomes.Radical surgery confers the best prognosis but remains feasible in a minority of patients. 展开更多
关键词 Gallbladder neoplasms Biliary tract neoplasms Adenocarcinoma Survival Prognostic factors Incidental cancer Surgical oncology Brazil
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Soil temperature and water content as determinants of non-structural carbohydrates concentrations in Picea crassifolia under continuous drought 认领 引用 被引量：1
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作者 Quanyan Tian Zhibin He +5 位作者 Shengchun Xiao Xiangyan Feng Huma Batool Xiaomei Peng Pengfei Lin Xi Zhu 《Journal of Forestry Research》 SCIE EI CAS CSCD 2026年第1期188-200,共13页
Non-structural carbohydrates(NSCs)are critical for plant drought adaptation,but their environmental drivers under prolonged drought remains unclear.We investigated seasonal NSCs dynamics in the leaf,stem and root of P... Non-structural carbohydrates(NSCs)are critical for plant drought adaptation,but their environmental drivers under prolonged drought remains unclear.We investigated seasonal NSCs dynamics in the leaf,stem and root of Picea crass ifolia(Qinghai spruce)during the growing seasons of2021-2023 under intensifying drought at three altitudes in Qilian Mountains,Northwest China.Our results revealed synchronous seasonal patterns in soluble sugar,starch,and total non-structural carbohydrate within the same year,contrasting with marked altitudinal disparities.As drought progressed(from 2021 to 2023),soluble sugars initially increased(2022)then declined(2023),while starch showed consistent reduction(except leaves).Moreover,the altitude of peak NSCs concentrations shifted from 3200 m in 2021to 2700 m in 2023.In particular,prolonged drought alters the environmental factors affecting NSCs.NSCs demonstrated significant positive correlations with soil temperature during humid 2021,then negatively with air temperature,vapor pressure deficit,and precipitation during 2022's initial drought,whereas under 2023's persistent drought conditions,soil temperature and water content emerged as dominant drivers.Concurrently,the ratio of soluble sugar to starch transitioned from air temperature and precipitation associations(2021-2022)to soil parameter dependence in2023.These findings provide new insights into the seasonal carbon dynamics of Qinghai spruce and the environmental response mechanisms under increasing drought stress,contributing to a better understanding of tree physiological adaptations in drought stress. 展开更多
关键词 Non-structural carbohydrates Evergreen conifer Environmental factors Drought Arid mountains
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Qiweizhigan granule ameliorates metabolic dysfunction-associated steatohepatitis by modulating the galectin 3/tumor necrosis factor receptor-associated factor 6-mediated ferroptosis 认领 引用 被引量：1
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作者 Yu-Nuo Yang Yun-Hong Sun +9 位作者 Ming-Zhe Zhu Yi-Rong Wang Meng Li Kai Wang Jing Ma Li Zhang Dan Hu Wen-Jun Zhou Guang Ji Yan-Qi Dang 《World Journal of Gastroenterology》 SCIE CAS 2026年第17期116-134,共19页
BACKGROUND Qiweizhigan granule(QWZG)is employed in clinical settings for the treatment of metabolic dysfunctionassociated steatohepatitis(MASH).However,the precise biological mechanisms underlying its therapeutic effe... BACKGROUND Qiweizhigan granule(QWZG)is employed in clinical settings for the treatment of metabolic dysfunctionassociated steatohepatitis(MASH).However,the precise biological mechanisms underlying its therapeutic effects are not yet fully elucidated.AIM To assess the efficacy and the mechanism of QWZG against MASH.METHODS Animal models were established,including normal group,a choline-deficient,L-amino acid-defined high-fat diet(CDAHFD)group,and low/medium/high-dose QWZG groups,as well as a rosiglitazone group.Through comprehensive biochemical,histopathological,RNA sequencing,and bioinformatics analyses,galectin 3(LGALS3)was identified as a critical target of QWZG in the treatment of MASH.The level of LGALS3 was quantitatively assessed and validated using Western blotting,real-time quantitative PCR,and immunofluorescence.The role and function of LGALS3 in inflammation and MASH progression were further investigated through gene knockdown,overexpression,iron assay,and transmission electron microscopy.RESULTS QWZG significantly ameliorated liver pathology by reducing steatosis,inflammation,and fibrosis.RNA sequencing analysis identified 1507 co-expressed differentially expressed genes among the CDAHFD,normal,and QWZG groups.Among these,LGALS3 was identified as one of the most significantly altered differentially expressed genes.Both mRNA and protein levels of LGALS3 were elevated in the CDAHFD group compared to the normal group,whereas treatment with QWZG reduced their levels.Analysis of Human Protein Atlas database indicated that LGALS3 was predominantly expressed in Kupffer cells,and was validated by real-time quantitative PCR and immunofluorescence.Furthermore,the level of LGALS3 was significantly increased in lipopolysaccharide-induced RAW264.7 cells,where its overexpression and recombinant LGALS3 protein both significantly enhanced the expression of interleukin-6,interleukin-1β,and tumor necrosis factor-α.LGALS3 overexpression significantly inhibited glutathione peroxidase 4(GPX4)expression,and exacerbated mitochondrial damage,whereas LGALS3 knockdown markedly increased GPX4 level,and significantly reduced the levels of both total iron and ferrous iron.QWZG treatment significantly reduced the levels of malondialdehyde and ferrous iron,increased the levels of superoxide dismutase and glutathione.In addition,QWZG treatment also significantly enhanced GPX4 expression.Mechanistically,LGALS3 knockdown was associated with reduced expression of tumor necrosis factor receptor-associated factor 6(TRAF6)and NOD-like receptor family pyrin domain containing 3,while its overexpression led to increased levels of these proteins.The TRAF6 inhibitor C25-140 effectively reversed the LGALS3-induced alterations in GPX4 expression and iron accumulation.Furthermore,QWZG treatment significantly decreased the levels of TRAF6 and NOD-like receptor family pyrin domain containing 3.CONCLUSION QWZG ameliorated the progression of MASH by modulating ferroptosis through the LGALS3/TRAF6/GPX4 axis. 展开更多
关键词 Qiweizhigan granule Metabolic dysfunction-associated steatohepatitis Galectin 3 Tumor necrosis factor receptorassociated factor 6 Ferroptosis
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A National Follow-up Study on the Effect of Health Protective Factors on Frailty Transition among Older Adults in China 认领 引用 被引量：1
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作者 Jing Shi Ziyi Zhou +12 位作者 Baiyu Zhou Yongkang Tao Yan Cen Luyao Zhang Sainan Li Ying Li Botao Sang Xiangfei Liu Qinan Ma Xuezhai Zeng Pulin Yu Jing Li Deping Liu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第3期270-284,共15页
Objective Frailty is becoming increasingly common among aging adults.Frailty transitionis shaped by biological,social,psychological,and environmental factors.This study investigated combined effects of protective fact... Objective Frailty is becoming increasingly common among aging adults.Frailty transitionis shaped by biological,social,psychological,and environmental factors.This study investigated combined effects of protective factors on frailty transition by constructing a Protection Index(PI)to guide targeted interventions.Methods Data were extracted from the 4th Sample Survey of the Aged Population in Urban and Rural China,including baseline(2017)and follow-up(2019)surveys.Frailty was assessed using the Frailty Index(FI),whereas the PI measured protective factors.Frailty transitions over 2 years were analyzed prospectively.Pearson’s correlation examined the relationship between FI and PI,and logistic regression assessed the effects of PI on frailty transitions.Results This study included 9,093 older adults.FI values increased with age and were higher in women,whereas PI values decreased with age and were higher in men.Over 2 years,56.2%of the participants showed a stable frailty status,14.2%improved,and 29.6%worsened.Negative transitions were more common than positive transitions,with transitions occurring most frequently between adjacent states.The PI was moderately negatively correlated with the FI(r=−0.349,P<0.001).A higher PI was associated with a lower risk of negative transitions among robust and prefrail individuals(OR=0.989,0.981,both P<0.05),but showed no significant effect among those with existing frailty.Conclusion Negative frailty transitions were more common with advancing age.Enhancing PI may help prevent negative frailty transitions among robust and pre-frail older adults,underscoring the value of early interventions. 展开更多
关键词 Frailty transition Frailty Older adults Protective factors Follow-up study National survey
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Serum Trace Elements and Their Associations with Disease Progression and Survival in Sporadic Amyotrophic Lateral Sclerosis:Insights from a Chinese Cohort 认领 引用 被引量：1
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作者 Hongfen Wang Qionghua Sun +5 位作者 Rongrong Du Shiya Wang Yan Wang Jiongming Bai Mao Li Xusheng Huang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第2期183-191,共9页
Objective The associations of serum trace element levels with disease progression and survival duration were assessed in individuals diagnosed with sporadic amyotrophic lateral sclerosis(sALS)in China.Methods Clinical... Objective The associations of serum trace element levels with disease progression and survival duration were assessed in individuals diagnosed with sporadic amyotrophic lateral sclerosis(sALS)in China.Methods Clinical data,including diagnostic indicators,clinical characteristics,Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised(ALSFRS-R)scores,and serum concentrations of calcium(Ca),magnesium(Mg),iron(Fe),copper(Cu),and zinc(Zn),were collected for hospitalized patients with sALS between 2018 and 2021.Correlation analysis,random forest analysis,and the Gehan-Breslow-Wilcoxon test were used to evaluate the relations between serum trace element levels,disease progression,and survival duration.Results Lower serum Ca levels and higher Mg levels were observed in patients with ALSFRS-R scores<39.Serum Mg was significantly negatively correlated with ALSFRS-R,trunk,and respiratory scores.Serum Cu and Zn also showed significant negative correlations with the respiratory score,whereas Ca and Fe were not significantly correlated with the ALSFRS-R score.The serum levels of Ca,Mg,Cu,Zn,and Fe remained consistent regardless of the site of disease onset.ALSFRS-R analysis revealed that serum Ca and Mg had a substantial effect on the total ALSFRS-R score,with serum Mg significantly influencing the course of the disease.Notably,low serum Mg levels were associated with extended survival times in patients with sALS.Conclusion Serum levels of Ca and Mg play critical roles in the progression of sALS,and a reduced serum Mg level is related to an extended survival time. 展开更多
关键词 Amyotrophic lateral sclerosis Metal/metalloid Microelement Risk factor
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NAC transcription factor PpNAP4 modulates sucrose accumulation by activating the expression of PpSUS1 and PpSPS2 during peach ripening 认领 引用 被引量：1
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作者 Jieyu Dai Ze Xu +7 位作者 Zhouheng Fang Qiancheng Han Pei Shi Jingwen Zhu Lijun Cao Hangkong Liu Yanan Hu Caiping Zhao 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第6期1318-1330,共13页
Sugars are crucial in determining fruit quality and significantly affect the commercial value.Sucrose is the primary soluble sugar in ripe peach fruit.However,the regulatorymechanism of sucrose synthesis in peach frui... Sugars are crucial in determining fruit quality and significantly affect the commercial value.Sucrose is the primary soluble sugar in ripe peach fruit.However,the regulatorymechanism of sucrose synthesis in peach fruit,especially during natural ripening,remains largely unexplored.This study identified two structural genes of peach(Prunus persica,‘Jinlinghuanglu’),PpSUS1 and PpSPS2,whose expression was strongly correlated with sucrose accumulation.The transcription factors that regulated the expression of these two genes during peach fruit ripening were screened;and three NACs(NAM,ATAF1/2 and CUC2),whose expression also significantly correlated with sucrose accumulation,were identified.Notably,PpNAP4(NAC-like,activated by APETALA3/PISTILLATA)displayed the highest activation activity toward the PpSUS1 and PpSPS2 promoters.The direct binding activity was confirmed using luciferase imaging and electrophoretic mobility shift assays.The sucrose content and expression of sucrose synthesis-related genes significantly increased when PpNAP4 was overexpressed in peach fruit and the tomato nor mutant.Moreover,PpNAP4 functioned synergistically with PpNAP6 to modulate sucrose synthesis,and PpNAP4 targeted its own promoter and feedback-activated its own expression.This research unveils a novel regulatory mechanism controlling sucrose accumulation in peach fruit. 展开更多
关键词 Prunus persica Sucrose NAC transcription factor PpNAP4 PpSUS1 PpSPS2
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Patterns,synergies,and interactions between human activities and living environment on the Qinghai-Xizang Plateau 认领 引用 被引量：1
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作者 GUO Changqing ZHANG Haiyan +2 位作者 DOU Yinyin KUANG Wenhui BAO Wenxuan 《Journal of Geographical Sciences》 SCIE CSCD 2026年第2期341-362,共22页
Understanding the impacts of human activities on the plateau’s living environment is essential for advancing modernization pathways that promote harmony between humanity and nature.However,studies on the dynamic inte... Understanding the impacts of human activities on the plateau’s living environment is essential for advancing modernization pathways that promote harmony between humanity and nature.However,studies on the dynamic interactions between human activities and the living environment on the Qinghai-Xizang Plateau(QXP)remain limited,with a paucity of quantitative relationship analyses.This study established an assessment framework to evaluate human influences on the living environment in QXP,using data on typical human activities,ecological conditions,and human settlements.Within this framework,the spatial analysis methods and the coupling coordination model were used to examine the spatio-temporal characteristics and relationship of human activities and living environment on the QXP from 2000 to 2020.The geographical detector model was then applied to identify the key factors influencing the plateau’s human living environment.Subsequently,the four-quadrant analysis model was adopted to assess human influences on the living environment.The results indicate that the human activity intensity(HAI)on the QXP remained relatively low yet increased by 15.41%from 2000 to 2020.Spatially,the human living environment quality(LEQ)improved from northwest to southeast,with 61.14%of the areas remaining stable and 18.47%experiencing slight improvement.The analysis of coupling coordination revealed a continuous improvement between the HAI and LEQ,with the areas of high and relatively high coordinated types increasing by more than 9%.Precipitation and urban-rural construction were identified as the primary factors influencing changes in the LEQ.The interaction between the HAI and LEQ was strengthening,with 40.44%classified as coordinated development type and 38.35%as development-environment conflict type.These findings provide valuable insights for enhancing the resilience of human settlements and promoting green development across the plateau. 展开更多
关键词 human activities living environment spatio-temporal characteristics coupling coordination influencing factor Qinghai-Xizang Plateau
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Ammonia emission from real-world in-use vehicle fleets in a megacity in China-based on tunnel measurement 认领 引用 被引量：1
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作者 Jiliang Guo Jinsheng Zhang +9 位作者 Ainan Song Hui Tong Jingchun Tang Ning Yang Zhuofei Du Qijun Zhang Ting Wang Lin Wu Jianfei Peng Hongjun MaoTianjin Key Laboratory of Urban Transport Emission Research&State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第1期577-584,共8页
Ammonia(NH3)has been widely recognized as a key precursor of atmospheric secondary aerosol formation.Vehicle emission is a major source of urban atmospheric NH3.With the tightening of emission standards and the growin... Ammonia(NH3)has been widely recognized as a key precursor of atmospheric secondary aerosol formation.Vehicle emission is a major source of urban atmospheric NH3.With the tightening of emission standards and the growing trend of vehicle fleet electrification,it is imperative to update the emission factors for NH3 from real-world on-road fleets.In this study,a tunnel measurement was conducted in the urban area of Tianjin,China.The fleet-average NH3 emission factor(EF)was 11.2 mg/(km·veh),significantly lower than those in previous studies,showing the benefit of emission standard updating.Through a multiple linear regression analysis,the EFs of light-duty gasoline vehicles,light-duty diesel vehicles,and heavy-duty diesel vehicles(HDDVs)were estimated to be 5.7±0.6 mg/(km·veh),40.8±5.1 mg/(km·veh),and 160.2±16.6 mg/(km·veh),respectively.Based on the results from this study,we found that HDDVs,which comprise<3%of the total vehicles may contribute approximately 22%of total NH3 emissions in Tianjin.Our results highlight NH3 emissions from HDDVs,a previously potentially overlooked source of NH3 emissions in urban areas.The actual on-road NH3 emissions from HDDVs may exceed current expectations,posing a growing concern for the future. 展开更多
关键词 Ammonia(NH3) Vehicle emission Emission factor Heavy-duty diesel vehicle
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Improvements in Fracture Parameter Evaluation of Mixed-Mode Problems Using Modified Peridynamics 认领 引用 被引量：1
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作者 Hanlin Wang Lei Ju +5 位作者 Yanzhuo Xue Lihao Yuan Qing Wang Duanfeng Han Satoyuki Tanaka Erkan Oterkus 《哈尔滨工程大学学报（英文版）》 CSCD 2026年第3期684-692,共9页
Peridynamics(PD),which underpins many meshfree methods,has found widespread applications in fracture mechanics.However,its accuracy in simulating shear behavior remains limited,particularly for mixed-mode fracture pro... Peridynamics(PD),which underpins many meshfree methods,has found widespread applications in fracture mechanics.However,its accuracy in simulating shear behavior remains limited,particularly for mixed-mode fracture problems.To address this,we propose a modified formulation of ordinary state-based PD(OSPD)that incorporates bond rotation behavior,including shear deformation and rigid body rotation(RBR).Using the peridynamic differential operator,the stress-free RBR component is identified and removed from the total displacement.The enhanced formulation is validated through classical benchmark problems,with stress intensity factors evaluated using the interaction integral method.Numerical results demonstrate excellent agreement with reference solutions from the literature and the original OSPD model,confirming the improved accuracy of the modified OSPD model.Notably,the modified model exhibits superior performance in simulating shear deformation,establishing its reliability in mixed-mode fracture analysis. 展开更多
关键词 Fracture analysis Peridynamics Stress intensity factors Interaction integral Shear deformation
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Big data-driven analysis of shale gas enrichment patterns:A case study of the Wufeng–Longmaxi Formation in the Sichuan Basin and its periphery 认领 引用 被引量：1
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作者 Zongquan Hu Jin Meng +10 位作者 Wei Du Yitian Xiao Chuanxiang Sun Guanping Wang Baojian Shen Tianrui Ye Dongjun Feng Zengqin Liu Longfei Lu Ruyue Wang Qianru Wang 《Energy Geoscience》 EI CAS CSCD 2026年第1期166-178,共13页
The Wufeng–Longmaxi Formation derives its name from the Upper Ordovician Wufeng Formation and the Lower Silurian Longmaxi Formation,found in sequence in the Sichuan Basin.This formation hosts rich shale gas reservoir... The Wufeng–Longmaxi Formation derives its name from the Upper Ordovician Wufeng Formation and the Lower Silurian Longmaxi Formation,found in sequence in the Sichuan Basin.This formation hosts rich shale gas reservoirs,and its shale gas enrichment patterns are examined in this study using data from 1197 shale samples collected from 14 wells.Five basic and three key parameters,eight in all,are assessed for each sample.The five basic parameters include burial depth and the contents of four mineral types—quartz,clay,carbonate,and other minerals;the three key parameters,representing shale gas enrichment,are total organic carbon(TOC)content,porosity,and gas content.The SHapley Additive exPlanations(SHAP)analysis originated in game theory is used here in an interpretable machine learning framework,to address issues of heterogeneous data structure,noisy relationships,and multi-objective optimization.An evaluation of the ranking,contribution values,and conditions of changes for these parameters offers new quantitative insights into shale gas enrichment patterns.A quantitative analysis of the relationship between data-sets identifies the primary factors controlling TOC,porosity,and gas content of shale gas reservoirs.The results show that TOC and porosity jointly influence gas content;mineral content has a significant impact on both,TOC and porosity;and the burial depth governs porosity which,in turn,affects the conditions under which shale gas is preserved.Input parameter thresholds are also determined and provide a basis for the establishment of quantitative criteria to evaluate shale gas enrichment.The predictive accuracy of the model used in this study is significantly improved by the step-wise addition of two input parameters,namely TOC and porosity,separately and together.Thus,the game theory method in big data-driven analysis uses a combination of TOC and porosity to evaluate the gas content with encouraging results—suggesting that these are the key parameters that indicate source rock and reservoir properties. 展开更多
关键词 Big data-driven analysis Primary controlling factor Shale gas enrichment pattern Wufeng–Longmaxi Formation Sichuan basin
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Dynamic behavior of steel post/wood panel railway noise barriers under aerodynamic loads induced by high-speed trains 认领 引用 被引量：1
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作者 Dongyun Liu Chao Wang +3 位作者 Jaime Gonzalez-Libreros Andréas Andersson Lennart Elfgren Gabriel Sas 《Railway Engineering Science》 EI 2026年第1期55-84,共30页
Railway noise barriers are an essential piece of infrastructure for reducing noise propagation.However,these barriers experience aerodynamic loads generated by high-speed trains,leading to dynamic effects that may com... Railway noise barriers are an essential piece of infrastructure for reducing noise propagation.However,these barriers experience aerodynamic loads generated by high-speed trains,leading to dynamic effects that may compromise their fatigue capacity.The most common structural design for railway noise barriers consists of vertical configurations of posts and panels.However,there have been few dynamic analyses of steel post/wood panel noise barriers under train-induced aerodynamic loads.This study used dynamic finite element analysis to assess the dynamic behavior of such noise barriers.Analysis of a 40-m-long noise barrier model and a triangular simplified load model,the latter of which effectively represented the detailed aerodynamic load,were first used to establish the model and input of the moving load during dynamic simulation.Then,the effects of different parameters on the dynamic response of the noise barrier were evaluated,including the damping ratio,the profile of the steel post,the span length of the panel,the barrier height,and the train speed.Gray relational analysis indicated that barrier height exhibited the highest correlations with the dynamic responses,followed by train speed,post profile,span length,and damping ratio.A reduction in the natural frequency and an increase in the train speed result in a higher peak response and more pronounced fluctuations between the nose and tail waves.The dynamic amplification factor(DAF)was found to be related to both the natural frequency and train speed.A model was proposed showing that the DAF significantly increases as the square of the natural frequency decreases and the cube of the train speed rises. 展开更多
关键词 Aerodynamic load Dynamic amplification factor Dynamic behavior Finite element analysis High-speed train Railway noise barrier
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