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Application of Prostate-Specific Antigen Density and Related Indicators in the Diagnosis of Prostate Cancer and Construction of a Risk Prediction Model 认领 引用
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作者 Yuanfu Qiu Lisi Huang +2 位作者 Longqiaozi Sun Jianfen Lei Chaohui Duan 《Journal of Bio-X Research》 2026年第2期137-148,共12页
Objectives:To investigate the diagnostic value of prostate-specific antigen density(PSAD),prostate volume(PV),free prostate-specific antigen(fPSA),total prostate-specific antigen(tPSA),and fPSAPSA in prostate cancer(P... Objectives:To investigate the diagnostic value of prostate-specific antigen density(PSAD),prostate volume(PV),free prostate-specific antigen(fPSA),total prostate-specific antigen(tPSA),and fPSAPSA in prostate cancer(PCa)and to construct a risk prediction model based on analyzed risk factors.Methods:Age,Gleason score of pathological biopsy,PV,fPSA,tPSA,fPSAPSA,and PSAD were retrospectively analyzed,and accuracy of the predictive model was evaluated using receiver operating characteristic curve and logistic regression analyses.An age×PSAD product term was introduced to test the interaction between age and PSAD,and the predictive efficacy of PSAD stratified by age was evaluated.Results:Multivariate logistic regression analysis suggested that PV,fPSA,tPSA,fPSAPSA,and PSAD were independent risk factors for PCa(P70-year-old group(OR=33.54,95%CI:19.38 to 58.05)(all P<0.001).Conclusion:The nomogram model constructed based on PV,fPSA,tPSA,fPSAPSA,and PSAD can effectively predict the probability of PCa occurrence.Among these factors,the predictive value of PSAD is age dependent and particularly prominent in individuals aged 60 to 70 years. 展开更多
关键词 construct risk prediction model total prostate specific antigen predictive model prostate specific antigen density analyzed risk factorsmethods agegleason free prostate specific antigen receiver operating characteristic curve prostate volume
Prevalence and correlates of depressive and anxiety symptoms among community-dwelling older adults in Shanghai 认领 引用
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作者 WANG Xian 《China Medical Abstracts(Internal Medicine)》 2026年第1期63-63,共1页
Objective To investigate the prevalence of depressive and anxiety symptoms among the older adults in Hongkou District,Shanghai,and to identify associated factors.Methods From February to March 2025,a convenience sampl... Objective To investigate the prevalence of depressive and anxiety symptoms among the older adults in Hongkou District,Shanghai,and to identify associated factors.Methods From February to March 2025,a convenience sampling approach was used to recruit individuals aged≥60 from the physical examination departments of community health service centers in Hongkou District.A total of 1 653 older adults were enrolled,and 1 643 valid questionnaires were obtained.The sample included 723males and 920 females,with a median age of 70 years(IQR:67-75). 展开更多
关键词 physical examination departments community dwelling older adults prevalence Hongkou district convenience sampling approach anxiety symptoms identify associated factorsmethods depressive symptoms
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Clinical characteristics and prognostic analysis of carbapenem-resistant Enterobacteriaceae bloodstream infections in patients with hematologic diseases 认领 引用
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作者 ZHANG Lining 《China Medical Abstracts(Internal Medicine)》 2025年第1期53-53,共1页
Objective To analyze the clinical and molecular characteristics of carbapenem-resistant Enterobacteriaceae(CRE)bloodstream infection(BSI)in patients with hematological diseases and to explore prognostic risk factors.M... Objective To analyze the clinical and molecular characteristics of carbapenem-resistant Enterobacteriaceae(CRE)bloodstream infection(BSI)in patients with hematological diseases and to explore prognostic risk factors.Methods This retrospective study included patients with hematologic diseases with CRE BSI at the Institute of Hematology and Blood Diseases Hospital from January 2015 to December 2022.The clinical features,carbapenemase test results,antimicrobial treatments,and outcomes were analyzed.Results A total of 120 patients developed CRE BSI.Escherichia coli(58/120,48.3%)was the most prevalent Enterobacteriaceae,followed by Klebsiella pneumoniae(52/120,43.3%).A total of 93 CRE strains were tested for carbapenemase,of which 75 strains produced carbapenemase(metalloenzyme:51 strains;serine enzyme:24 strains).The 30-day mortality rate after BSI was 24.2%(29/120).Univariate analysis revealed significantly lower mortality in patients treated with the ceftazidime-avibactam-containing regimen than in those treated with other antibiotics(7.8%vs 36.2%,P<0.001).Moreover,initiating active therapy within 24 h of BSI onset significantly reduced mortality(15.0%us 33.3%,P=0.019).The proportion of patients with CRE colonization receiving active therapy within 12 and 24 h was significantly higher compared with patients without colonization(12 h:14.5%vs 34.1%,P=0.012;24 h:40.8%vs 65.9%,P=0.008).Multivariate analysis revealed that septic shock(HR=24.436,95%CI 4.148-143.966,P<0.001)and pulmonary infection(HR=9.346,95%CI 2.718-32.140,P<0.001)were independent risk factors for death within 30 days.Appropriate therapy was initiated within 24 h(HR=0.225,95%CI 0.059-0.851,P=0.028),and treatment with the ceftazidimeavibactam-containing regimen(HR=0.082,95%CI 0.018-0.362,P=0.001)significantly reduced mortality.Conclusion The prognosis of CRE BSI in patients with hematological diseases is poor.Timely,appropriatetherapyandd receipt of a ceftazidimeavibactamcontaining regimen can improve survival and prognosis. 展开更多
关键词 Carbapenem resistant Enterobacteriaceae prognostic risk factorsmethods clinical molecular characteristics Hematologic Diseases Prognostic Factors hematological diseases Clinical Characteristics Bloodstream Infections
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