Pedestrian detection has been a hot spot in computer vision over the past decades due to the wide spectrum of promising applications,and the major challenge is false positives that occur during pedestrian detection.Th...Pedestrian detection has been a hot spot in computer vision over the past decades due to the wide spectrum of promising applications,and the major challenge is false positives that occur during pedestrian detection.The emergence of various Convolutional Neural Network-based detection strategies substantially enhances pedestrian detection accuracy but still does not solve this problem well.This paper deeply analyzes the detection framework of the two-stage CNN detection methods and finds out false positives in detection results are due to its training strategy misclassifying some false proposals,thus weakening the classification capability of the following subnetwork and hardly suppressing false ones.To solve this problem,this paper proposes a pedestrian-sensitive training algorithm to help two-stage CNN detection methods effectively learn to distinguish the pedestrian and non-pedestrian samples and suppress the false positives in the final detection results.The core of the proposed algorithm is to redesign the training proposal generating scheme for the two-stage CNN detection methods,which can avoid a certain number of false ones that mislead its training process.With the help of the proposed algorithm,the detection accuracy of the MetroNext,a smaller and more accurate metro passenger detector,is further improved,which further decreases false ones in its metro passenger detection results.Based on various challenging benchmark datasets,experiment results have demonstrated that the feasibility of the proposed algorithm is effective in improving pedestrian detection accuracy by removing false positives.Compared with the existing state-of-the-art detection networks,PSTNet demonstrates better overall prediction performance in accuracy,total number of parameters,and inference time;thus,it can become a practical solution for hunting pedestrians on various hardware platforms,especially for mobile and edge devices.展开更多
During the last decade, hundreds of studies have been pub- lished examining whether significant associations exist be- tween mitochondrial DNA (mtDNA) variants and/or haplogroups (clades) and particular diseases ...During the last decade, hundreds of studies have been pub- lished examining whether significant associations exist be- tween mitochondrial DNA (mtDNA) variants and/or haplogroups (clades) and particular diseases (generally com- mon/complex diseases) (Fig. 1). However, several authors have gathered evidence indicating a high incidence of false positive findings in mtDNA case-control association studies. Raule et al. (2007) and Herrnstadt and Howell (2004) showed various problems affecting mtDNA case-control association studies. Salas et al.展开更多
[Objective] The aim was to explore the reasons of false positives in Different Display Reverse Transcription(DDRT)analysis.[Method] Soybean varieties "Jilin 30" and "Tongnong 13" were used as materials to carry ...[Objective] The aim was to explore the reasons of false positives in Different Display Reverse Transcription(DDRT)analysis.[Method] Soybean varieties "Jilin 30" and "Tongnong 13" were used as materials to carry out analysis on false positives in DDRT analysis.[Result] An important origin of false positives appeared in DDRT analysis was the non-specific amplification caused by the combination of single primer and cDNA.The parallel PCR test of single primer should be set so as to verify whether the obtained fragments were the false positives or the PCR productions combined with single primer.[Conclusion] This study had provided basis for improving the success rate of DDRT experiment.展开更多
The use of environmental DNA(eDNA)has significantly revolutionized studies in biodiversity science.A crucial innovation of eDNA-based biodiversity assessment is the ability to detect species through genetic materials ...The use of environmental DNA(eDNA)has significantly revolutionized studies in biodiversity science.A crucial innovation of eDNA-based biodiversity assessment is the ability to detect species through genetic materials released by organisms into their environments,without the need for direct observation or capture(i.e.,organisms remain“unseen”).The fact that organisms remain“unseen”has many pros and cons,many of which have been largely recognized and technically addressed or managed.However,two recent studies have both highlighted another critical issue regarding eDNA-based biodiversity assessments:the prevalence of overlooked eDNA contamination originating from human activities,such as the release of treated wastewater into aquatic ecosystems.Such eDNA contamination derived from human activities can lead to significant false positive errors in eDNA-based biodiversity assessments,particularly in human-disturbed ecosystems such as urban and coastal environments.Here I discuss the causes and consequences of eDNA contamination,stressing that this widespread but often neglected issue can substantially affect both eDNA-based theoretical studies and applied biodiversity management.Additionally,I propose several potential technical solutions to minimize its negative impacts,including well-designed sampling strategies,a deeper understanding of eDNA persistence and its spread in local waterbodies,and the use of environmental RNA(eRNA).Given that eDNA contamination can significantly impact ecosystems such as urban and coastal environments where biodiversity provides essential ecosystem services,I call for precautionary approaches and technical efforts to mitigate false positives derived from eDNA contamination in biodiversity assessments in these ecosystems.展开更多
Vessel segmentation is a fundamental task in medical image analysis and plays an important role in computer-aided diagnosis,lesion localization,vascular morphology analysis,and subsequent three-dimensional reconstruct...Vessel segmentation is a fundamental task in medical image analysis and plays an important role in computer-aided diagnosis,lesion localization,vascular morphology analysis,and subsequent three-dimensional reconstruction.However,blood vessels usually exhibit elongated shapes,complex branching patterns,significant scale variations,and locally low contrast.Under challenging conditions such as complex backgrounds,noise interference,and blurred boundaries,tiny vessels are prone to missed detection,while background textures and spurious edges are easily misclassified as vessels,resulting in increased false positives.To address these issues,this paper proposes a prior-guided vessel segmentation method with false positive suppression.The proposed method adopts an encoderdecoder architecture as the backbone and introduces a Vessel False Positive Suppression Gate(VFPSGate)into the skip connections during the decoding stage.By integrating vessel region priors and edge priors,the shallow features are recalibrated in a suppression-oriented manner,thereby reducing the interference of background noise and non-vascular high responses on segmentation results.In addition,a Vessel False Positive Suppression Loss(VFPSLoss)is designed to impose extra constraints on abnormally high responses in background regions that are not supported by the priors,thus enhancing the model’s targeted suppression ability against false positives at the optimization level.Experimental results on the DCA dataset demonstrate that the proposed method achieves competitive performance,with IoU,DSC,ACC,and SEN reaching 66.49%,79.72%,97.88%,and 85.16%,respectively.Overall,the proposed method can more effectively distinguish real vessels from pseudo-vessels,providing a feasible solution for vessel segmentation under complex background conditions.展开更多
BACKGROUND Certain subgroups are at an increased risk of false fecal immunochemical test(FIT)results;however,related studies are limited,and the available evidence is conflicting.AIM To evaluate factors associated wit...BACKGROUND Certain subgroups are at an increased risk of false fecal immunochemical test(FIT)results;however,related studies are limited,and the available evidence is conflicting.AIM To evaluate factors associated with false-positive and false-negative FIT results.METHODS This retrospective study was based on the database of the Tianjin Colorectal Cancer Screening Program from 2012 to 2020.A total of 4129947 residents aged 40-74 years completed at least one FIT.Of these,24890 asymptomatic participants who underwent colonoscopy examinations and completed lifestyle questionnaires were included in the analysis.Multivariable logistic regression was performed to identify the factors associated with false FIT results.RESULTS Among the overall screening population,88687(2.15%)participants tested positive for FIT.The sensitivity,specificity,positive predictive value,and negative predictive value of FIT for advanced neoplasms were 58.2%,44.8%,9.7%,and 91.3%,respectively.Older age,female sex,smoking,alcohol consumption,higher body mass index,and hemorrhoids were significantly associated with increased odds of false-positive and lower odds of falsenegative FIT results.Moreover,features of high-grade dysplasia or villous for advanced adenoma and the presence of cancer were also associated with lower odds of false-negative results,while irregular exercise and diverticulum were associated with higher odds of false-positive results.CONCLUSION FIT results may be inaccurate in certain subgroups.Our results provide important evidence for further individualization of screening strategies.展开更多
Highlights·By integrating RT-RAA with CRISPR/Cas12a,a portable,one-pot visual detection system was engineered,significantly minimizing the potential for false positives caused by aerosol contamination.·RT-RA...Highlights·By integrating RT-RAA with CRISPR/Cas12a,a portable,one-pot visual detection system was engineered,significantly minimizing the potential for false positives caused by aerosol contamination.·RT-RAA-CRISPR/Cas12a assay can complete the detection within 40 min,with a sensitivity as high as 3.9 copiesμL-1for single copy.Porcine deltacoronavirus(PDCo V)disease is an acute and highly contagious illness caused by the PDCo V.展开更多
Despite advancements in neuroimaging,false positive diagnoses of intracranial aneurysms remain a significant concern.This article examines the causes,prevalence,and implications of such false-positive diagnoses.We dis...Despite advancements in neuroimaging,false positive diagnoses of intracranial aneurysms remain a significant concern.This article examines the causes,prevalence,and implications of such false-positive diagnoses.We discuss how conditions like arterial occlusion with vascular stump formation and infundibular widening can mimic aneurysms,particularly in the anterior circulation.The article compares various imaging modalities,including computer tomography angiogram,magnetic resonance imaging/angiography,and digital subtraction angiogram,highlighting their strengths and limitations.We emphasize the im-portance of accurate differentiation to avoid unnecessary surgical interventions.The potential of emerging technologies,such as high-resolution vessel wall ima-ging and deep neural networks for automated detection,is explored as promising avenues for improving diagnostic accuracy.This manuscript underscores the need for continued research and clinical vigilance in the diagnosis of intracranial aneurysms.展开更多
Strange correlator is a powerful tool widely used in detecting symmetry-protected topological(SPT)phases.However,the result of strange correlator crucially relies on the adoption of the reference state.In this work,we...Strange correlator is a powerful tool widely used in detecting symmetry-protected topological(SPT)phases.However,the result of strange correlator crucially relies on the adoption of the reference state.In this work,we report that an ill-chosen reference state can induce spurious long-range strange correlators in trivial SPT phases,leading to false positives in SPT diagnosis.展开更多
Advanced Persistent Threats(APTs)are stealthy cyberattacks that can evade detection in system-level audit logs.Provenance graphs encode these logs as interacting entities and events,exposing a causal and dependency st...Advanced Persistent Threats(APTs)are stealthy cyberattacks that can evade detection in system-level audit logs.Provenance graphs encode these logs as interacting entities and events,exposing a causal and dependency structure that is often obscured in linear representations.Prior provenance-based detectors typically apply anomaly detection over such graphs,yet they frequently incur high false-positive rates and produce coarse grained alerts;moreover,approaches that heavily depend on node-specific identifiers(e.g.,file paths)can learn spurious correlations,reducing robustness and limiting reliability across heterogeneous workloads.In this paper,we present Self-Training Adaptive Graph Encoder(stage),a lightweight,self-supervised anomaly detection framework for provenance graphs that(i)trains without attack labels and(ii)enforces leakage-free model selection and thresholding with explicit control over false-alarm rates.STAGE uses learnable degree and node-type embeddings,processed by a compact two-layer Graph Convolutional Networks(GCN)with residual connections and dual pooling.A memory augmented attention module captures global benign prototypes,improving resilience to rare-but-legitimate behaviors,and suppressing false alarms.Training combines contrastive learning over augmented graph views with a one-class Support Vector Data Description(SVDD)objective that learns a compact benign hypersphere in the embedding space.Inference,STAGE fuses neural embeddings with fixed dimensional structural graph statistics and scores them using an ensemble of classical one-class detectors.As a result,STAGE attains strong ranking quality and practical operating points on two benchmarks:the StreamSpot and Wget datasets.In the StreamSpot dataset,STAGE achieves an AUC of 0.998,operating at 95%recall with a 0%false positive rate.On the Wget dataset,it attains an AUC of 0.998 and an average precision of 0.998,achieving 100%recall and 96%precision at a 4%false positive rate.Overall,STAGE demonstrates strong empirical separability for benign-only provenance-based detection and provides an explicit mechanism to trade off recall and false positive rate through predefined thresholding policies.展开更多
At present,with the development of technology,the detection of cryptococcal antigen(CRAG)plays an increasingly important role in the diagnosis of cryptococcosis.However,the three major CRAG detection technologies,late...At present,with the development of technology,the detection of cryptococcal antigen(CRAG)plays an increasingly important role in the diagnosis of cryptococcosis.However,the three major CRAG detection technologies,latex agglutination test(LA),lateral flow assay(LFA)and Enzyme-linked Immunosorbent Assay,have certain limitations.Although these techniques do not often lead to false-positive results,once this result occurs in a particular group of patients(such as human immunodeficiency virus patients),it might lead to severe consequences.展开更多
A new modification of false position method for solving nonlinear equations is presented by applying homotopy analysis method (HAM). Some numerical illustrations are given to show the efficiency of algorithm.
Objective To investigate if immunological factors associated with rheumatoid arthritis(RA) affect the result of human immunodeficiency virus(HIV) screening by electrochemiluminescence immunoassay(ECLIA) and enzyme-lin...Objective To investigate if immunological factors associated with rheumatoid arthritis(RA) affect the result of human immunodeficiency virus(HIV) screening by electrochemiluminescence immunoassay(ECLIA) and enzyme-linked immunosorbent assay(ELISA). Methods 100 RA cases were enrolled from January 2012 to February 2013 into this study. HIV screening was conducted with ECLIA detecting both HIV-1 p24 antigen, HIV-1 and HIV-2 antibodies, with ELISA and colloidal gold method detecting HIV-1 and HIV-2 antibodies. The samples producing positive results were submitted to the Center for Disease Control for confirmation using Western blotting method. The antibody titers of rheumatoid factors(RF) including RF-IgG, RF-IgM, RF-IgA, and CCP-IgG were analyzed by ELISA. Results The HIV positive-rate determined by ECLIA was significantly higher than that by ELISA and colloidal gold method(P<0.01). The false-positive rate of HIV screening was associated with antibody titers of RF-IgG, RF-IgM, RF-IgA, and CCP-IgG in RA(P<0.01). Conclusion Immunological factors, including RF and anti-CCP antibody, may influence the screening of HIV by ECLIA, producing false-positive result.展开更多
Lung cancer, the leading cause of cancer deaths worldwide and in China, has a 19.7% five-year survival rate due to terminal-stage diagnosis[1-3].Although low-dose computed tomography(CT) screening can reduce mortal...Lung cancer, the leading cause of cancer deaths worldwide and in China, has a 19.7% five-year survival rate due to terminal-stage diagnosis[1-3].Although low-dose computed tomography(CT) screening can reduce mortality, high false positive rates can create economic and psychological burdens.展开更多
Introduction: HIV screening tests are routinely conducted on dialysis patients as the constant exposure of their blood during the dialysis process makes them a reasonable risk for blood-borne infections. However, in l...Introduction: HIV screening tests are routinely conducted on dialysis patients as the constant exposure of their blood during the dialysis process makes them a reasonable risk for blood-borne infections. However, in low prevalence settings, where HIV rates are <0.1% of the population, false positive results are more likely. This results in apprehension in the dialysis unit as breaches in infectious disease protocols could be presumed. This is illustrated in the case report below. Case Summary: A 62-year-old male Saudi end-stage kidney disease patient secondary to DM nephropathy began dialysis a year before presentation in a hemodialysis center in Saudi Arabia. Routine screening tests done at the start of dialysis revealed negative Hepatitis C, HIV 1 and 2 screening but a positive Hepatitis B surface antigen screen. The patient went for holiday dialysis at another facility and had a routine fourth-generation HIV test done which was positive. A confirmatory HIV PCR test was negative. Conclusion: This case highlights the need for caution in interpreting highly sensitive and specific HIV screening tests in a low-prevalence setting. Routine screening beyond the national recommendation may not be necessary in low-prevalence areas.展开更多
To detect security vulnerabilities in a web application,the security analyst must choose the best performance Security Analysis Static Tool(SAST)in terms of discovering the greatest number of security vulnerabilities ...To detect security vulnerabilities in a web application,the security analyst must choose the best performance Security Analysis Static Tool(SAST)in terms of discovering the greatest number of security vulnerabilities as possible.To compare static analysis tools for web applications,an adapted benchmark to the vulnerability categories included in the known standard Open Web Application Security Project(OWASP)Top Ten project is required.The information of the security effectiveness of a commercial static analysis tool is not usually a publicly accessible research and the state of the art on static security tool analyzers shows that the different design and implementation of those tools has different effectiveness rates in terms of security performance.Given the significant cost of commercial tools,this paper studies the performance of seven static tools using a new methodology proposal and a new benchmark designed for vulnerability categories included in the known standard OWASP Top Ten project.Thus,the practitioners will have more precise information to select the best tool using a benchmark adapted to the last versions of OWASP Top Ten project.The results of this work have been obtaining using widely acceptable metrics to classify them according to three different degree of web application criticality.展开更多
To solve the problem of poor detection and limited application range of current intrusion detection methods,this paper attempts to use deep learning neural network technology to study a new type of intrusion detection...To solve the problem of poor detection and limited application range of current intrusion detection methods,this paper attempts to use deep learning neural network technology to study a new type of intrusion detection method.Hence,we proposed an intrusion detection algorithm based on convolutional neural network(CNN)and AdaBoost algorithm.This algorithm uses CNN to extract the characteristics of network traffic data,which is particularly suitable for the analysis of continuous and classified attack data.The AdaBoost algorithm is used to classify network attack data that improved the detection effect of unbalanced data classification.We adopt the UNSW-NB15 dataset to test of this algorithm in the PyCharm environment.The results show that the detection rate of algorithm is99.27%and the false positive rate is lower than 0.98%.Comparative analysis shows that this algorithm has advantages over existing methods in terms of detection rate and false positive rate for small proportion of attack data.展开更多
With the continuous development of network technology,various large-scale cyber-attacks continue to emerge.These attacks pose a severe threat to the security of systems,networks,and data.Therefore,how to mine attack p...With the continuous development of network technology,various large-scale cyber-attacks continue to emerge.These attacks pose a severe threat to the security of systems,networks,and data.Therefore,how to mine attack patterns from massive data and detect attacks are urgent problems.In this paper,an approach for attack mining and detection is proposed that performs tasks of alarm correlation,false-positive elimination,attack mining,and attack prediction.Based on the idea of CluStream,the proposed approach implements a flow clustering method and a two-step algorithm that guarantees efficient streaming and clustering.The context of an alarm in the attack chain is analyzed and the LightGBM method is used to perform falsepositive recognition with high accuracy.To accelerate the search for the filtered alarm sequence data to mine attack patterns,the PrefixSpan algorithm is also updated in the store strategy.The updated PrefixSpan increases the processing efficiency and achieves a better result than the original one in experiments.With Bayesian theory,the transition probability for the sequence pattern string is calculated and the alarm transition probability table constructed to draw the attack graph.Finally,a long-short-term memory network and embedding word-vector method are used to perform online prediction.Results of numerical experiments show that the method proposed in this paper has a strong practical value for attack detection and prediction.展开更多
Most patients treated with curative intent for colorectal cancer(CRC) are included in a follow-up program involving periodic evaluations. The survival benefits of a follow-up program are well delineated, and previous ...Most patients treated with curative intent for colorectal cancer(CRC) are included in a follow-up program involving periodic evaluations. The survival benefits of a follow-up program are well delineated, and previous meta-analyses have suggested an overall survival improvement of 5%-10% by intensive follow-up. However, in a recent randomized trial, there was no survival benefit when a minimal vs an intensive follow-up program was compared. Less is known about the potential side effects of follow-up. Well-known side effects of preventive programs are those of somatic complications caused by testing, negative psychological conse-quences of follow-up itself, and the downstream impact of false positive or false negative tests. Accordingly, the potential survival benefits of CRC follow-up must be weighed against these potential negatives. The present review compares the benefits and side effects of CRC follow-up, and we propose future areas for research.展开更多
A Bloom filter is a space-efficient data structure used for concisely representing a set as well as membership queries at the expense of introducing false positive. In this paper, we propose the L-priorities Bloom fil...A Bloom filter is a space-efficient data structure used for concisely representing a set as well as membership queries at the expense of introducing false positive. In this paper, we propose the L-priorities Bloom filter (LPBF) as a new member of the Bloom filter (BF) family, it uses a limited multidimensional bit space matrix to replace the bit vector of standard bloom filters in order to support different priorities for the elements of a set. We demonstrate the time and space complexity, especially the false positive rate of LPBF. Furthermore, we also present a detailed practical evaluation of the false positive rate achieved by LPBF. The results show that LPBF performs better than standard BFs with respect to false positive rate.展开更多
摘要Pedestrian detection has been a hot spot in computer vision over the past decades due to the wide spectrum of promising applications,and the major challenge is false positives that occur during pedestrian detection.The emergence of various Convolutional Neural Network-based detection strategies substantially enhances pedestrian detection accuracy but still does not solve this problem well.This paper deeply analyzes the detection framework of the two-stage CNN detection methods and finds out false positives in detection results are due to its training strategy misclassifying some false proposals,thus weakening the classification capability of the following subnetwork and hardly suppressing false ones.To solve this problem,this paper proposes a pedestrian-sensitive training algorithm to help two-stage CNN detection methods effectively learn to distinguish the pedestrian and non-pedestrian samples and suppress the false positives in the final detection results.The core of the proposed algorithm is to redesign the training proposal generating scheme for the two-stage CNN detection methods,which can avoid a certain number of false ones that mislead its training process.With the help of the proposed algorithm,the detection accuracy of the MetroNext,a smaller and more accurate metro passenger detector,is further improved,which further decreases false ones in its metro passenger detection results.Based on various challenging benchmark datasets,experiment results have demonstrated that the feasibility of the proposed algorithm is effective in improving pedestrian detection accuracy by removing false positives.Compared with the existing state-of-the-art detection networks,PSTNet demonstrates better overall prediction performance in accuracy,total number of parameters,and inference time;thus,it can become a practical solution for hunting pedestrians on various hardware platforms,especially for mobile and edge devices.
基金the "Ministerio de Ciencia e Innovacio'n"(No.SAF2011-26983)the Plan Galego IDT(No.EM 2012/045)the grant from the Sistema Universitario Gallego-Modalidad REDES(No.2012-PG226,to A.Salas) from the Xunta de Galicia
摘要During the last decade, hundreds of studies have been pub- lished examining whether significant associations exist be- tween mitochondrial DNA (mtDNA) variants and/or haplogroups (clades) and particular diseases (generally com- mon/complex diseases) (Fig. 1). However, several authors have gathered evidence indicating a high incidence of false positive findings in mtDNA case-control association studies. Raule et al. (2007) and Herrnstadt and Howell (2004) showed various problems affecting mtDNA case-control association studies. Salas et al.
摘要[Objective] The aim was to explore the reasons of false positives in Different Display Reverse Transcription(DDRT)analysis.[Method] Soybean varieties "Jilin 30" and "Tongnong 13" were used as materials to carry out analysis on false positives in DDRT analysis.[Result] An important origin of false positives appeared in DDRT analysis was the non-specific amplification caused by the combination of single primer and cDNA.The parallel PCR test of single primer should be set so as to verify whether the obtained fragments were the false positives or the PCR productions combined with single primer.[Conclusion] This study had provided basis for improving the success rate of DDRT experiment.
基金funded by the National Key Research and Development Program of China(grant number:2021YFC3200102)Guiding Funds of Central Government for Supporting the Development of Local Science and Technology(grant number:2024ZY0128)Yunnan Collaborative Innovation Center for Plateau Lake Ecology and Environmental Health.
摘要The use of environmental DNA(eDNA)has significantly revolutionized studies in biodiversity science.A crucial innovation of eDNA-based biodiversity assessment is the ability to detect species through genetic materials released by organisms into their environments,without the need for direct observation or capture(i.e.,organisms remain“unseen”).The fact that organisms remain“unseen”has many pros and cons,many of which have been largely recognized and technically addressed or managed.However,two recent studies have both highlighted another critical issue regarding eDNA-based biodiversity assessments:the prevalence of overlooked eDNA contamination originating from human activities,such as the release of treated wastewater into aquatic ecosystems.Such eDNA contamination derived from human activities can lead to significant false positive errors in eDNA-based biodiversity assessments,particularly in human-disturbed ecosystems such as urban and coastal environments.Here I discuss the causes and consequences of eDNA contamination,stressing that this widespread but often neglected issue can substantially affect both eDNA-based theoretical studies and applied biodiversity management.Additionally,I propose several potential technical solutions to minimize its negative impacts,including well-designed sampling strategies,a deeper understanding of eDNA persistence and its spread in local waterbodies,and the use of environmental RNA(eRNA).Given that eDNA contamination can significantly impact ecosystems such as urban and coastal environments where biodiversity provides essential ecosystem services,I call for precautionary approaches and technical efforts to mitigate false positives derived from eDNA contamination in biodiversity assessments in these ecosystems.
摘要Vessel segmentation is a fundamental task in medical image analysis and plays an important role in computer-aided diagnosis,lesion localization,vascular morphology analysis,and subsequent three-dimensional reconstruction.However,blood vessels usually exhibit elongated shapes,complex branching patterns,significant scale variations,and locally low contrast.Under challenging conditions such as complex backgrounds,noise interference,and blurred boundaries,tiny vessels are prone to missed detection,while background textures and spurious edges are easily misclassified as vessels,resulting in increased false positives.To address these issues,this paper proposes a prior-guided vessel segmentation method with false positive suppression.The proposed method adopts an encoderdecoder architecture as the backbone and introduces a Vessel False Positive Suppression Gate(VFPSGate)into the skip connections during the decoding stage.By integrating vessel region priors and edge priors,the shallow features are recalibrated in a suppression-oriented manner,thereby reducing the interference of background noise and non-vascular high responses on segmentation results.In addition,a Vessel False Positive Suppression Loss(VFPSLoss)is designed to impose extra constraints on abnormally high responses in background regions that are not supported by the priors,thus enhancing the model’s targeted suppression ability against false positives at the optimization level.Experimental results on the DCA dataset demonstrate that the proposed method achieves competitive performance,with IoU,DSC,ACC,and SEN reaching 66.49%,79.72%,97.88%,and 85.16%,respectively.Overall,the proposed method can more effectively distinguish real vessels from pseudo-vessels,providing a feasible solution for vessel segmentation under complex background conditions.
基金Supported by Natural Science Foundation of Tianjin,No.21JCZDJC00060 and No.21JCYBJC00180Tianjin Health and Medical Science and Technology Project,No.TJWJ2023QN040National Key Research and Development Program,No.2017YFC1700606 and No.2017YFC1700604.
摘要BACKGROUND Certain subgroups are at an increased risk of false fecal immunochemical test(FIT)results;however,related studies are limited,and the available evidence is conflicting.AIM To evaluate factors associated with false-positive and false-negative FIT results.METHODS This retrospective study was based on the database of the Tianjin Colorectal Cancer Screening Program from 2012 to 2020.A total of 4129947 residents aged 40-74 years completed at least one FIT.Of these,24890 asymptomatic participants who underwent colonoscopy examinations and completed lifestyle questionnaires were included in the analysis.Multivariable logistic regression was performed to identify the factors associated with false FIT results.RESULTS Among the overall screening population,88687(2.15%)participants tested positive for FIT.The sensitivity,specificity,positive predictive value,and negative predictive value of FIT for advanced neoplasms were 58.2%,44.8%,9.7%,and 91.3%,respectively.Older age,female sex,smoking,alcohol consumption,higher body mass index,and hemorrhoids were significantly associated with increased odds of false-positive and lower odds of falsenegative FIT results.Moreover,features of high-grade dysplasia or villous for advanced adenoma and the presence of cancer were also associated with lower odds of false-negative results,while irregular exercise and diverticulum were associated with higher odds of false-positive results.CONCLUSION FIT results may be inaccurate in certain subgroups.Our results provide important evidence for further individualization of screening strategies.
基金financially supported by the National Key Research and Development Program of China(2021YFF0703600)。
摘要Highlights·By integrating RT-RAA with CRISPR/Cas12a,a portable,one-pot visual detection system was engineered,significantly minimizing the potential for false positives caused by aerosol contamination.·RT-RAA-CRISPR/Cas12a assay can complete the detection within 40 min,with a sensitivity as high as 3.9 copiesμL-1for single copy.Porcine deltacoronavirus(PDCo V)disease is an acute and highly contagious illness caused by the PDCo V.
摘要Despite advancements in neuroimaging,false positive diagnoses of intracranial aneurysms remain a significant concern.This article examines the causes,prevalence,and implications of such false-positive diagnoses.We discuss how conditions like arterial occlusion with vascular stump formation and infundibular widening can mimic aneurysms,particularly in the anterior circulation.The article compares various imaging modalities,including computer tomography angiogram,magnetic resonance imaging/angiography,and digital subtraction angiogram,highlighting their strengths and limitations.We emphasize the im-portance of accurate differentiation to avoid unnecessary surgical interventions.The potential of emerging technologies,such as high-resolution vessel wall ima-ging and deep neural networks for automated detection,is explored as promising avenues for improving diagnostic accuracy.This manuscript underscores the need for continued research and clinical vigilance in the diagnosis of intracranial aneurysms.
基金supported by the National Natural Science Foundation of China(Grant Nos.12474149,12374166 for ZXL,and 12134020for ZXL)the National Key Research and Development Program of China(Grant Nos.2022YFA1405300 and 2023YFA1406500 for ZXL)+1 种基金Research Center for Magnetoelectric Physics of Guangdong Province(Grant No.2024B0303390001)Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices(Grant No.2022B1212010008)。
摘要Strange correlator is a powerful tool widely used in detecting symmetry-protected topological(SPT)phases.However,the result of strange correlator crucially relies on the adoption of the reference state.In this work,we report that an ill-chosen reference state can induce spurious long-range strange correlators in trivial SPT phases,leading to false positives in SPT diagnosis.
基金funded by Umm Al-Qura University,Saudi Arabia,under grant number 26UQU4400257GSSR10.
摘要Advanced Persistent Threats(APTs)are stealthy cyberattacks that can evade detection in system-level audit logs.Provenance graphs encode these logs as interacting entities and events,exposing a causal and dependency structure that is often obscured in linear representations.Prior provenance-based detectors typically apply anomaly detection over such graphs,yet they frequently incur high false-positive rates and produce coarse grained alerts;moreover,approaches that heavily depend on node-specific identifiers(e.g.,file paths)can learn spurious correlations,reducing robustness and limiting reliability across heterogeneous workloads.In this paper,we present Self-Training Adaptive Graph Encoder(stage),a lightweight,self-supervised anomaly detection framework for provenance graphs that(i)trains without attack labels and(ii)enforces leakage-free model selection and thresholding with explicit control over false-alarm rates.STAGE uses learnable degree and node-type embeddings,processed by a compact two-layer Graph Convolutional Networks(GCN)with residual connections and dual pooling.A memory augmented attention module captures global benign prototypes,improving resilience to rare-but-legitimate behaviors,and suppressing false alarms.Training combines contrastive learning over augmented graph views with a one-class Support Vector Data Description(SVDD)objective that learns a compact benign hypersphere in the embedding space.Inference,STAGE fuses neural embeddings with fixed dimensional structural graph statistics and scores them using an ensemble of classical one-class detectors.As a result,STAGE attains strong ranking quality and practical operating points on two benchmarks:the StreamSpot and Wget datasets.In the StreamSpot dataset,STAGE achieves an AUC of 0.998,operating at 95%recall with a 0%false positive rate.On the Wget dataset,it attains an AUC of 0.998 and an average precision of 0.998,achieving 100%recall and 96%precision at a 4%false positive rate.Overall,STAGE demonstrates strong empirical separability for benign-only provenance-based detection and provides an explicit mechanism to trade off recall and false positive rate through predefined thresholding policies.
基金Supported by the Key Discipline of Jiaxing Respiratory Medicine Construction Project,No.2019-zc-04.
摘要At present,with the development of technology,the detection of cryptococcal antigen(CRAG)plays an increasingly important role in the diagnosis of cryptococcosis.However,the three major CRAG detection technologies,latex agglutination test(LA),lateral flow assay(LFA)and Enzyme-linked Immunosorbent Assay,have certain limitations.Although these techniques do not often lead to false-positive results,once this result occurs in a particular group of patients(such as human immunodeficiency virus patients),it might lead to severe consequences.
摘要A new modification of false position method for solving nonlinear equations is presented by applying homotopy analysis method (HAM). Some numerical illustrations are given to show the efficiency of algorithm.
基金Supported by Shanghai Municipal Natural Science Foundation(11ZR1427000)
摘要Objective To investigate if immunological factors associated with rheumatoid arthritis(RA) affect the result of human immunodeficiency virus(HIV) screening by electrochemiluminescence immunoassay(ECLIA) and enzyme-linked immunosorbent assay(ELISA). Methods 100 RA cases were enrolled from January 2012 to February 2013 into this study. HIV screening was conducted with ECLIA detecting both HIV-1 p24 antigen, HIV-1 and HIV-2 antibodies, with ELISA and colloidal gold method detecting HIV-1 and HIV-2 antibodies. The samples producing positive results were submitted to the Center for Disease Control for confirmation using Western blotting method. The antibody titers of rheumatoid factors(RF) including RF-IgG, RF-IgM, RF-IgA, and CCP-IgG were analyzed by ELISA. Results The HIV positive-rate determined by ECLIA was significantly higher than that by ELISA and colloidal gold method(P<0.01). The false-positive rate of HIV screening was associated with antibody titers of RF-IgG, RF-IgM, RF-IgA, and CCP-IgG in RA(P<0.01). Conclusion Immunological factors, including RF and anti-CCP antibody, may influence the screening of HIV by ECLIA, producing false-positive result.
基金supported by the National Natural Science Foundation of China(grant numbers 82204127 and 72204172)。
摘要Lung cancer, the leading cause of cancer deaths worldwide and in China, has a 19.7% five-year survival rate due to terminal-stage diagnosis[1-3].Although low-dose computed tomography(CT) screening can reduce mortality, high false positive rates can create economic and psychological burdens.
摘要Introduction: HIV screening tests are routinely conducted on dialysis patients as the constant exposure of their blood during the dialysis process makes them a reasonable risk for blood-borne infections. However, in low prevalence settings, where HIV rates are <0.1% of the population, false positive results are more likely. This results in apprehension in the dialysis unit as breaches in infectious disease protocols could be presumed. This is illustrated in the case report below. Case Summary: A 62-year-old male Saudi end-stage kidney disease patient secondary to DM nephropathy began dialysis a year before presentation in a hemodialysis center in Saudi Arabia. Routine screening tests done at the start of dialysis revealed negative Hepatitis C, HIV 1 and 2 screening but a positive Hepatitis B surface antigen screen. The patient went for holiday dialysis at another facility and had a routine fourth-generation HIV test done which was positive. A confirmatory HIV PCR test was negative. Conclusion: This case highlights the need for caution in interpreting highly sensitive and specific HIV screening tests in a low-prevalence setting. Routine screening beyond the national recommendation may not be necessary in low-prevalence areas.
摘要To detect security vulnerabilities in a web application,the security analyst must choose the best performance Security Analysis Static Tool(SAST)in terms of discovering the greatest number of security vulnerabilities as possible.To compare static analysis tools for web applications,an adapted benchmark to the vulnerability categories included in the known standard Open Web Application Security Project(OWASP)Top Ten project is required.The information of the security effectiveness of a commercial static analysis tool is not usually a publicly accessible research and the state of the art on static security tool analyzers shows that the different design and implementation of those tools has different effectiveness rates in terms of security performance.Given the significant cost of commercial tools,this paper studies the performance of seven static tools using a new methodology proposal and a new benchmark designed for vulnerability categories included in the known standard OWASP Top Ten project.Thus,the practitioners will have more precise information to select the best tool using a benchmark adapted to the last versions of OWASP Top Ten project.The results of this work have been obtaining using widely acceptable metrics to classify them according to three different degree of web application criticality.
基金supported in part by the National Key R&D Program of China(No.2022YFB3904503)National Natural Science Foundation of China(No.62172418)。
摘要To solve the problem of poor detection and limited application range of current intrusion detection methods,this paper attempts to use deep learning neural network technology to study a new type of intrusion detection method.Hence,we proposed an intrusion detection algorithm based on convolutional neural network(CNN)and AdaBoost algorithm.This algorithm uses CNN to extract the characteristics of network traffic data,which is particularly suitable for the analysis of continuous and classified attack data.The AdaBoost algorithm is used to classify network attack data that improved the detection effect of unbalanced data classification.We adopt the UNSW-NB15 dataset to test of this algorithm in the PyCharm environment.The results show that the detection rate of algorithm is99.27%and the false positive rate is lower than 0.98%.Comparative analysis shows that this algorithm has advantages over existing methods in terms of detection rate and false positive rate for small proportion of attack data.
基金This work is supported by the National Key R&D Program of China(2016QY05X1000)the National Natural Science Foundation of China(Grant No.201561402137).
摘要With the continuous development of network technology,various large-scale cyber-attacks continue to emerge.These attacks pose a severe threat to the security of systems,networks,and data.Therefore,how to mine attack patterns from massive data and detect attacks are urgent problems.In this paper,an approach for attack mining and detection is proposed that performs tasks of alarm correlation,false-positive elimination,attack mining,and attack prediction.Based on the idea of CluStream,the proposed approach implements a flow clustering method and a two-step algorithm that guarantees efficient streaming and clustering.The context of an alarm in the attack chain is analyzed and the LightGBM method is used to perform falsepositive recognition with high accuracy.To accelerate the search for the filtered alarm sequence data to mine attack patterns,the PrefixSpan algorithm is also updated in the store strategy.The updated PrefixSpan increases the processing efficiency and achieves a better result than the original one in experiments.With Bayesian theory,the transition probability for the sequence pattern string is calculated and the alarm transition probability table constructed to draw the attack graph.Finally,a long-short-term memory network and embedding word-vector method are used to perform online prediction.Results of numerical experiments show that the method proposed in this paper has a strong practical value for attack detection and prediction.
基金Supported by Norwegian Health Authorities Research Grant
摘要Most patients treated with curative intent for colorectal cancer(CRC) are included in a follow-up program involving periodic evaluations. The survival benefits of a follow-up program are well delineated, and previous meta-analyses have suggested an overall survival improvement of 5%-10% by intensive follow-up. However, in a recent randomized trial, there was no survival benefit when a minimal vs an intensive follow-up program was compared. Less is known about the potential side effects of follow-up. Well-known side effects of preventive programs are those of somatic complications caused by testing, negative psychological conse-quences of follow-up itself, and the downstream impact of false positive or false negative tests. Accordingly, the potential survival benefits of CRC follow-up must be weighed against these potential negatives. The present review compares the benefits and side effects of CRC follow-up, and we propose future areas for research.
基金supported by Project of Plan for Science and Technology Development of Jilin Province (No. 20101504)Project of Research of Science and Technology for the 11th Five-year Plan of Jilin Education Department (No. 2009604)
摘要A Bloom filter is a space-efficient data structure used for concisely representing a set as well as membership queries at the expense of introducing false positive. In this paper, we propose the L-priorities Bloom filter (LPBF) as a new member of the Bloom filter (BF) family, it uses a limited multidimensional bit space matrix to replace the bit vector of standard bloom filters in order to support different priorities for the elements of a set. We demonstrate the time and space complexity, especially the false positive rate of LPBF. Furthermore, we also present a detailed practical evaluation of the false positive rate achieved by LPBF. The results show that LPBF performs better than standard BFs with respect to false positive rate.