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Integrative clustering by colonic volatile fatty acids reveals microbiota and host physiological variation in weaned piglets 认领 引用
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作者 Chengcheng Li Stijn Heirbaut +5 位作者 Joris Michiels Yuhuang Hou Anneke Ovyn Noémie Van Noten Elout Van Liefferinge Jeroen Degroote 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第3期1554-1572,共19页
Background Volatile fatty acids(VFAs)reflect microbial fermentation linking gut microbiota,metabolism and host physiology.However,endogenous VFA profiles and their physiological relevance remain insufficiently charact... Background Volatile fatty acids(VFAs)reflect microbial fermentation linking gut microbiota,metabolism and host physiology.However,endogenous VFA profiles and their physiological relevance remain insufficiently characterized.This study aimed to identify distinct VFA phenotypes in weaned piglets and reveal how microbial fermentation patterns connect gut metabolism with animal health and performance.Results In this study,we integrated six independent trials comprising 164 weaned piglets.Here,k-means clustering of six VFAs in colonic digesta to identified two metabolite phenotypes:high level of short-chain fatty acids(HSCFA)and high level of branched-chain fatty acids(HBCFA).Generally,The HSCFA group exhibited significantly higher concentrations of VFA(P<0.001),and lower levels of ammonia and serum urea(P<0.001),consistent with enhanced carbohydrate fermentation and reduced nitrogen output.Additionally,the HSCFA group had significantly greater villus height in the distal small intestine(P<0.01),lower mid-colonic pH(P<0.001)and thrombocyte counts(P<0.01).In contrast,the HBCFA group showed elevated levels of branched-chain fatty acids and ammonia(P<0.001),as well as enrichment of Escherichia-Shigella,Rikenellaceae dgA-11 gut group and Prevotella(adjusted P<0.05).The HSCFA group was enriched in Lactobacillus,Mitsuokella and Dialister(adjusted P<0.05),and exhibited higher final body weight and average daily gain(P<0.05),indicating better growth performance.To explore associations between gut microbiota and VFA phenotypes,an XGBoost classification model was trained,based on genus-level composition,to predict the metabolic phenotype.It achieved a moderate accuracy and identified Unclassified Eubacterium coprostanoligenes group,Lactobacillus and Escherichia-Shigella as important genera contributing to group separation.Conclusions Clustering based on colonic VFA profiles identified distinct microbial and physiological patterns that may influence gut function and growth performance in weaned piglets.The enrichment of beneficial microbes and fermentation products in the HSCFA group suggests a more favorable intestinal environment,while protein fermentation in the colon seems associated with reduced animal performance and less beneficial intestinal environment. 展开更多
关键词 Branched-chain fatty acids Microbiota Short-chain fatty acids Weaned piglets
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n-3 Polyunsaturated fatty acids substitution for saturated fatty acids in diet ameliorates age-related cognitive decline via ABCA1/ApoE-mediated lipid efflux 认领 引用
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作者 Xin Zhang Tianzhi Xie +8 位作者 Kemin Guo Xinran Liu Shuang Zhou Tian Yuan Yongbo She Rui Guo Jun Hu Xuebo Liu Zhigang Liu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第6期2821-2832,共12页
Dietary lipids are essential for brain health.However,high-fat diets(HFD)have produced conflicting results in studies on aging brain health,likely due to variations in fatty acid composition.While aging-related glial ... Dietary lipids are essential for brain health.However,high-fat diets(HFD)have produced conflicting results in studies on aging brain health,likely due to variations in fatty acid composition.While aging-related glial lipid accumulation is exacerbated by saturated fatty acids(SFAs)-rich HFD,it remains unclear whether replacing SFAs with n-3 polyunsaturated fatty acids(PUFAs)can mitigate this effect and the associated neuroinflammation.This study investigates the effects of SFAs-rich and n-3 PUFAs-rich HFDs in 18-monthold C57BL/6J mice over a 12-week period.Mice fed the SFAs-rich HFD showed increased body weight,elevated glucose and lipid levels,and lipid accumulation in glial cells.Behavioral tests,including novel object recognition and the Barnes maze,revealed significant cognitive impairments in these mice.In contrast,the n-3PUFAs-rich HFD increased brain docosahexaenoic acid levels,activated the ATP-binding cassette transporter Al/apolipoprotein E pathway,reduced lipid accumulation in glial cells,and ultimately reversed cognitive decline.Consistent with these findings,the n-3 PUFAs-rich diet also attenuated inflammatory markers such as tumor necrosis factorαand interleukin 1β,and decreased oxidative stress markers including malondialdehyde and oxidized glutathioneeduced glutathione.These findings provide novel insights into the role of fatty acid composition in HFD affecting aged brain health,offering strong evidence for the neuroprotective benefits of n-3 PUFAs-enriched diets. 展开更多
关键词 Age-related cognitive decline Saturated fatty acids Lipid accumulation n-3 Polyunsaturated fatty acids
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Obakulactone Alleviates Rheumatoid Arthritis by Promotion of ACOT1 Degradation via the Ubiquitin‒Proteasome Pathway and Restoration of Unsaturated Fatty Acid Homeostasis 认领 引用
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作者 Hongda Liu Le Yang +12 位作者 Yu Yang Huan Tang Junling Ren Hui Sun Xin Sun Songyuan Tang Chong Qiu Ye Sun Jigang Wang Guangli Yan Ling Kong Ying Han Xijun Wang 《Engineering》 SCIE EI CSCD 2026年第1期341-360,共20页
Rheumatoid arthritis(RA)remains a therapeutic challenge because of the suboptimal efficacy and significant adverse effects of current treatments.Obakulactone(OL),a natural tetracyclic triterpenoid isolated from Phello... Rheumatoid arthritis(RA)remains a therapeutic challenge because of the suboptimal efficacy and significant adverse effects of current treatments.Obakulactone(OL),a natural tetracyclic triterpenoid isolated from Phellodendri cortex,has emerged as a promising candidate for RA intervention.However,its underlying mechanism remains poorly understood.In this study,we investigated the therapeutic effects of OL and its molecular mechanisms in RA using a multifaceted approach.A complete Freund's adjuvant(CFA)-induced RA rat model revealed that OL significantly alleviated joint swelling and restored the expression of CD3+T cells and CD68+macrophages in joints,and the polarization state of macrophages shifted from proinflammatory M1(CD86)to anti-inflammatory M2(CD206)dominant.In addition,OL alleviated pathological changes in lymphoid organs(thymus and spleen),effectively inhibited the differentiation of CD4+T cells into T helper 17(Th17)cells,and normalized serum levels of inflammatory cytokines(e.g.,interleukin(IL)-6 and tumor necrosis factor-α(TNF-α))and RA diagnostic markers(e.g.,creactive protein(CRP)and rheumatoid factor(RF)).Multiomics profiling revealed that OL corrected the dysregulated biosynthesis and metabolism of unsaturated fatty acids(e.g.,arachidonic acid and linolenic acid)in RA rats,with acyl coenzyme A(CoA)thioesterase 1(ACOT1)identified as a critical regulator.In vitro studies have shown that OL significantly inhibits cell proliferation and inflammatory cytokine secretion and promotes the apoptosis of RA synovial fibroblasts(SFs).It inhibited the M1 polarization of Raw264.7 macrophages and promoted M2 polarization.Mechanistically,cellular thermal shift assays(CETSA),microscale thermo phoresis(MST),surface plasmon resonance(SPR),and short hairpin RNA(shRNA)experiments revealed ACOT1 as the direct target of OL.OL enhanced ACOT1 ubiquitinationmediated proteasomal degradation,thereby reducing downstream stearoyl-CoA desaturase-1 expression and inhibiting the Janus kinase(JAK)-signal transducer and activator of transcription(STAT)and phosphoinositide 3-kinase(PI3K)-protein kinase B(AKT)signaling pathways,thus suppressing inflammation and fibrosis in SFs.This study establishes OL as a potential RA therapeutic agent and highlights ACOT1 as a novel target for RA intervention,offering insights into fatty acid metabolism reprogramming as a therapeutic strategy. 展开更多
关键词 Obakulactone Rheumatoid arthritis Unsaturated fatty acids Acyl coenzyme A thioesterase 1 Synovial fibroblasts Multiomics Ubiquitin-proteasome pathway
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ACSL4 is a target forβ-hydroxybutyrate-induced increase in fatty acid content and lipid droplet accumulation in bovine mammary epithelial cells 认领 引用
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作者 Ming Li Jingjing Wang +8 位作者 Jia’nan Wen Juan JLoor Qianming Jiang Jingyi Wang Huijing Zhang Yue Yang Wei Yang Bingbing Zhang Chuang Xu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第3期1137-1149,共13页
Ketosis,a common metabolic disease during early lactation,is associated with high circulating levels ofβ-hydroxybutyrate(BHB).A portion of BHB that reaches the mammary gland is utilized as precursor for synthesis of ... Ketosis,a common metabolic disease during early lactation,is associated with high circulating levels ofβ-hydroxybutyrate(BHB).A portion of BHB that reaches the mammary gland is utilized as precursor for synthesis of fatty acids.Recent findings from nonruminant studies revealed that long chain fatty acyl-CoA ligase 4(ACSL4)could play a role in the regulation of cellular fatty acid metabolism,but the mechanisms by which ACSL4 mediates cellular lipid metabolism in response to BHB remains unclear.To achieve the aims,we conducted in vivo or in vitro analyses using bovine mammary gland biopsies and the immortalized mammary epithelial cell line(MAC-T).The in vivo study(n=6 cows per group)involved healthy cows(plasma BHB2.0 mmol L–1)from which mammary gland tissue was biopsied.In vitro,MAC-T cells were challenged with 0,0.3,0.6,1.2,or 2.4 mmol L–1BHB for 24 h to determine an optimal dose.Subsequently,MAC-T were incubated with 1.2 mmol L–1BHB for 0,3,6,12,24,or 48 h.Furthermore,MAC-T cells were treated with small interfering ACSL4(siACSL4)for 24 h or ACSL4 overexpression plasmid(pcACSL4)for 36 h followed by a challenge with 1.2 mmol L–1BHB for 24 h.Results showed that increased mRNA and protein abundance of lipogenic genes were linked to both mammary gland and in vitro challenge with BHB.BHB increased fatty acid content by activating ACSL4 expression,whereas inhibition of ACSL4 reduced BHB-induced reactive oxygen species(ROS)overproduction,enhancement of mitochondrial membrane potential,increase in fatty acid content,and lipid droplet accumulation.Furthermore,we also elevated ACSL4 expression with an overexpression plasmid to clarify its molecular role in response to BHB challenge.ACSL4 overexpression enhances BHB-induced lipid droplet accumulation by increased fatty acid content.Overall,the information showed that ACSL4 is crucial for the process of producing fatty acids from exogenous BHB.Reduced ACSL4 decreased fatty acid content and lipid droplet accumulation,improved mitochondrial function,directed more fatty acids towards oxidation.Thus,ACSL4 plays an important role in determining the fate of intracellular fatty acids and BHB in BMECs. 展开更多
关键词 bovine mammary epithelial cells fatty acid content ketosis BHB ACSL4
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Prolonged consumption of white beer increases levels of short-chain fatty acids and Prevotellaceae bacteria in mice 认领 引用
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作者 Zhaoxi Liu Yongheng Rong +5 位作者 Shuxia Huang Hua Yin Lushan Wang Shumin Hu Junhong Yu Min Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期67-79,共13页
Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as... Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as a comprehensive intervention on human health and immune status.This study used a 14-day continuous drinking intervention consisting of 5 beers,namely white beer,India pale ale(IPA),Pilsner,non-alcoholic beer,and premium lager beer.Surprisingly,our findings indicate that consuming white beer has little impact on the gut microbiota and physiological condition of mice,whereas consuming other types of beer leads to an increase in Lactobacillus and a decrease in Lachnospiraceae.In addition,we devised an extended feeding experiment to investigate the comparative safety and health benefits of consuming white beer.The research showed that when mice drank excessive quantities of white beer over 42 days,the intestines of the mice had more Prevotellaceae and the Firmicutes to Bacteroidetes ratio(F/B ratio)had a decline from 1.29 to 0.38.The levels of acetic acid,propionic acid,and isobutyric acid increased from 1.0,0.27,and 0.015 mg/g to 1.28,0.38,and 0.037 mg/g,respectively(P<0.05).There were no significant changes observed in the levels of most measured cytokines in the colon tissue of mice that consumed beer,however,there was an increase in the concentration of the inflammatory factor tumor nesrosis factor-α(TNF-α)from 135.86 pg/mL in the control group to 189.78 pg/mL in the white beer group(P<0.01).These results give us real-world proof that we can use to study how different beers affect the host’s health and satisfaction in future research. 展开更多
关键词 Gut microbiota Beer Cytokine Short-chain fatty acids White beer Prevotellaceae
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Tuning biochar surface area for optimal chain elongation:a strategy for high-efficiency medium-chain fatty acids production 认领 引用
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作者 Yuhao Liu Lei Zhao +7 位作者 Haiping Gu Xinyi Wang Bingjie Wang Kui Wang Wei Huang Han Yang Jingjing Zhang Junjiao Zhang 《ENGINEERING Environment》 SCIE EI CAS CSCD 2026年第2期127-142,共16页
This study used ethanol and acetate as substrates,anaerobic digestion sludge as inoculum,and selected bamboo charcoal with three particle size conditions(<25,45–75,100–250μm)as the mediating material.While maint... This study used ethanol and acetate as substrates,anaerobic digestion sludge as inoculum,and selected bamboo charcoal with three particle size conditions(<25,45–75,100–250μm)as the mediating material.While maintaining consistent electrical conductivity levels of bamboo charcoal,we investigated the effect of specific surface area on the chain elongation reactions.Experimental results demonstrated that when bamboo charcoal served as the mediating material,larger specific surface area significantly enhanced the chain elongation for the production of medium-chain fatty acids.Microbial community composition analysis via 16S rRNA sequencing demonstrated that bamboo charcoal intervention promoted the enrichment of Clostridium_sensu_stricto_12,a keystone functional microbe exhibiting statistically significant positive correlations with the yield,electron transfer efficiency,and selectivity of MCFAs.Metagenomic analysis identified the simultaneous presence of reverseβ-oxidation and fatty acid biosynthesis pathways,with reverseβ-oxidation pathway serving as the dominant route.Notably,the Candidatus_Microthrix genus exhibited dual functionality by engaging in both pathways for MCFAs production. 展开更多
关键词 Chain elongation Bamboo biochar Specific surface area Medium-chain fatty acids Reverseβ-oxidation pathway
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Recent advances in the analysis of unsaturated fatty acids in biological samples based on chemical derivatization and mass spectrometry techniques 认领 引用
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作者 Yuanyuan Lin Ningbo Chen +5 位作者 Wenda Chen Fan Yin Ling Yang Xuan Chen Jian-Liang Zhou Tian Xie 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第3期692-707,共16页
Fatty acids(FAs)play a vital role in various physiological processes in the human body,and the analysis of FA isomers is of utmost importance in the research of various diseases and FA metabolic pathways.Over the last... Fatty acids(FAs)play a vital role in various physiological processes in the human body,and the analysis of FA isomers is of utmost importance in the research of various diseases and FA metabolic pathways.Over the last few years,the use of chemical derivatization methods to alter the composition of FAs has been found to be highly effective in overcoming the drawback of poor sensitivity in mass spectrometry(MS)analysis due to the poor ionizability of functional groups in FA molecules.Furthermore,certain chemical derivatization methods have enabled detection of C=C and differentiation of cis-trans isomers.As a result,the development and use of chemical derivatization-based MS to analyze FAs has gained significant interest.This review highlights technological innovations in the development of MS detection methods for unsaturated FAs(UFAs)based on chemical derivatization.Special emphasis is placed on two significant strategies:carboxyl group derivatization and C=C derivatization.In addition,it focuses on applications in various fields,discusses persistent challenges,and explores potential future directions.This review aims to provide a perspective on the advanced design and development of MS detection methods of FAs based on chemical derivatization. 展开更多
关键词 Fatty acids Chemical derivatization Unsaturated C=C bonds Carboxyl group Mass spectrometry
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Inheritance and QTL mapping identify multi-effect loci for fatty acid related traits in peanut(Arachis hypogaea L.) 认领 引用
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作者 Guanghao Wang Hui Wang +7 位作者 Liangqiong He Zhuqiang Han Jiaowen Pan Huan Zhang Lei Hou Xingjun Wang Baozhu Guo Chuanzhi Zhao 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第6期2329-2340,共12页
Peanut(Arachis hypogaea L.)is an important oil and edible protein crop.Its fatty acid composition not only infiuences the quality of peanut oil but also impacts fiavor,shelf life,and consumer health.Peanut oil is comp... Peanut(Arachis hypogaea L.)is an important oil and edible protein crop.Its fatty acid composition not only infiuences the quality of peanut oil but also impacts fiavor,shelf life,and consumer health.Peanut oil is comprised of approximately 80%oleic acid(C18:1)and linoleic acid(C18:2),10%palmitic acid(C16:0),and the remaining 10%includes stearic acid(C18:0),arachidic acid(C20:0),gadoleic acid(C20:1),behenic acid(C22:0),and lignoceric acid(C24:0).To unravel the genetic foundation of fatty acid content and delve into QTL localization,high-density SNP microarrays were used to genotype the RIL population of‘Sun Oleic 97R'בNC94022'.A genetic linkage map was constructed with 3,141 SNP markers,covering a total genetic distance of 3,051.81 c M.Sixty quantitative trait loci(QTLs)associated with fatty acids were distributed in 11 linkage groups,with phenotypic variance explained(PVE)ranging from 1.37 to 44.92%.Notably,the QTLs q FAT_A05.1 and q FAT_A08.1 are multiple-effect loci contributing to various fatty acid compositions.Moreover,15 haplotypes for the QTLs q FAT_A05.1 and q FAT_A08.1 were identified through genotyping 178 peanut germplasms.Haplotype analysis in a natural population confirmed the close relationship of the QTLs with the contents of oil,oleic acid,lignoceric acid,palmitic acid and behenic acid.This study serves as a valuable reference for selecting improved peanut genotypes with superior oil quality and desirable fatty acid composition. 展开更多
关键词 peanut fatty acid QTL genetic map
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Gut microbiota-mediated short-chain fatty acids contribute to the protective effects of Xiaoxuming decoction(小续命汤)against lipopolysaccharide-induced acute lung injury 认领 引用
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作者 XIANG Yijin YANG Zhigang +2 位作者 GONG Shaomin LI Xiangting CAI Min 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第2期285-293,共9页
OBJECTIVE:To investigate the mechanisms underlying the protective effects of Xiaoxuming decoction(小续命汤,XXMD)against lipopolysaccharide(LPS)-induced acute lung injury(ALI).METHODS:LPS was used to construct an ALI m... OBJECTIVE:To investigate the mechanisms underlying the protective effects of Xiaoxuming decoction(小续命汤,XXMD)against lipopolysaccharide(LPS)-induced acute lung injury(ALI).METHODS:LPS was used to construct an ALI model in mice and human pulmonary alveolar epithelial cells(HPAEpiCs).Acetate and acetate-producing bacteria,including Blautia hydrotrophica,Bacteroides thetaiotaomicron,Akkermansia muciniphila,and Bacteroides vulgatus,were detected after XXMD treatment.Zonula occludens-1(ZO-1),occludin,phosphorylated nuclear factor-kappa B p65(p-NF-κBp65),and NF-κBp65 levels were measured by Western blotting,and an enzyme-linked immunosorbent assay was performed to detect tumor necrosis factor-alpha(TNF-α),interleukin-1 beta(IL-1β),and IL-6 secretion.Transepithelial electrical resistance,fluorescein isothiocyanate-dextran,and cell counting kit-8 assays were used to detect the cell's monolayer integrity,permeability,and viability.RESULTS:XXMD alleviated the LPS-induced downregulation of acetate and acetate-producing bacteria in feces.Furthermore,XXMD suppressed the LPS-induced downregulation of ZO-1 and occludin expression in lung tissues,LPS-induced upregulation of TNF-α,IL-1β,and IL-6 in bronchoalveolar lavage fluid,and p-NF-κBp65 levels in lung tissues.Acetate had similar effects in LPS-induced mice.Meanwhile,the seven-day survival probability was improved by XXMD or acetate treatment.Furthermore,acetate could alleviate LPS-mediated cell viability,inflammation,and permeability in HPAEpiCs,while acetate-induced effects could be abrogated by GLPG0974,a short-chain fatty acid(SCFA)receptor G-protein coupled receptor 43 antagonist.CONCLUSION:XXMD's therapeutic effect may be related to gut microbiota-mediated SCFAs,which alleviated LPS-induced ALI. 展开更多
关键词 acute lung injury short-chain fatty acids permeability Xiaoxuming decoction
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The flotation separation of fluorite and calcite particles facilitated by a novel fatty acid-based surfactant 认领 引用
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作者 LIU Peng TIAN Yu-hui +1 位作者 TIAN Meng-jie SUN Wei 《Journal of Central South University》 SCIE EI CAS CSCD 2026年第3期1188-1202,共15页
Oleic acid is a commonly used fatty acid collector in fluorite flotation,known for its effective collecting performance and cost-effectiveness,but with a limited selectivity.In this study,a novel collector,α-sulfonat... Oleic acid is a commonly used fatty acid collector in fluorite flotation,known for its effective collecting performance and cost-effectiveness,but with a limited selectivity.In this study,a novel collector,α-sulfonate group mixed acid(α-SMA),is introduced.The flotation test results demonstrate that the α-SMA collector provides significantly better selectivity in fluorite flotation.Specifically,the α-SMA collector exhibits a similar collecting ability to oleic acid for fluorite;however,its capacity to collect calcite is substantially lower.Zeta potential tests indicate that,under identical dosage conditions,α-SMA adsorbs in greater quantities on fluorite than on calcite.As a result,fluorite exhibits substantially higher flotation recoveries versus calcite with α-SMA collector.X-ray photoelectron spectroscopic analysis suggests that α-SMA facilitates a higher electron donation to Ca2+ions on fluorite compared to calcite surface,forming stronger chemical bonds with fluorite surface.This enhanced interaction leads to stronger adsorption of α-SMA on fluorite.Furthermore,when α-SMA adsorbs solely through its sulfonic group,its carbon chain is positioned almost parallel to calcite surface.This configuration significantly reduces the hydrophobicity of the calcite surface,leading to very low calcite recovery rates with α-SMA collector. 展开更多
关键词 fluorite flotation collector oleic acid fatty acid α-sulfonate group
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Progress on Omega-3 fatty acids for the comprehensive and targeted treatment of spinal cord injury 认领 引用
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作者 Zhongze Yuan Lusen Shi +15 位作者 Xiao-Na Tao Xiangchuang Fan Han Zheng Yifan Shang Xiaoqing Zhao Fan Yang Hui Lin Peng Xiao Bo Chu Jichuan Qiu Shaohui Zong Ning Ran Xiaohong Kong Jin-Peng Sun Hengxing Zhou Shiqing Feng 《Bone Research》 SCIE CAS CSCD 2026年第1期62-81,共20页
Traumatic spinal cord injury(SCI)is a debilitating condition characterized by the impairment of neural circuits,leading to the loss of motor and sensory functions and accompanied by severe complications.Substantial re... Traumatic spinal cord injury(SCI)is a debilitating condition characterized by the impairment of neural circuits,leading to the loss of motor and sensory functions and accompanied by severe complications.Substantial research has reported the therapeutic potential of Omega-3 fatty acids for the central nervous system,particularly after traumatic SCI.Omega-3 fatty acids may contribute to improving SCI recovery through their anti-inflammatory,anti-oxidative,neurotrophic,and membrane integrity-preserving properties.These functions of Omega-3 fatty acids are primarily mediated via the activation of G protein-coupled receptor 120(GPR120),commonly known as the fish oil-specific receptor.Advancements in understanding of the molecular mechanisms of GPR120’s recognition of Omega-3 fatty acids and its downstream signaling mechanisms has significantly promoted research on the pharmacological potential of Omega-3 fatty acids and the development of highly selective and high-affinity alternatives.This review aims to provide in-depth analysis of the comprehensive therapeutic potential of Omega-3 fatty acids for SCI and its accompanying complications,and the prospects for developing novel drugs based on the recognition of Omega-3 fatty acids by GPR120. 展开更多
关键词 central nervous systemparticularly impairment neural circuitsleading spinal cord injury traumatic spinal cord injury omega fatty acids sensory functions traumatic spinal cord injury sci neural circuits
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Size and light scattering enhancement of sea spray aerosol via condensing fatty acid vapor 认领 引用
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作者 Minglan Xu Narcisse Tsona Tchinda +1 位作者 Siyang Li Lin Du 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第7期693-702,共10页
Once sea spray aerosol(SSA)particles are emitted into the atmosphere,they tend to interact with organic compounds and form a certain amount of organic coating on their surfaces.Here,laboratory measurements were perfor... Once sea spray aerosol(SSA)particles are emitted into the atmosphere,they tend to interact with organic compounds and form a certain amount of organic coating on their surfaces.Here,laboratory measurements were performed to investigate property changes between uncoated and coated SSA particles to assess the effect of organic coating on the surface chemistry and optical properties of nascent SSA.Stearic acid,oleic acid and mixed fatty acid were used as a proxy for coating materials and applied to aerosols produced by SSA generator.We found that the geometric mean diameter of SSA particles increased with increasing concentration of the fatty acid vapor due to higher heating temperatures,suggesting the formation of thicker coatings.Characterization by Fourier transform infrared spectroscopy and transmission electron microscope demonstrated that the SSA surface was coated with an organic coating of fatty acids,which gave the SSA a core–shell morphology.Furthermore,optical measurements by photo-acoustic extinctiometer at 375 nm revealed significantly enhanced light scattering efficiency and complex refractive index from fatty acid-coated SSA particles.The current results suggest that the fatty acid coating changes the diameter and surface composition of SSA particles,which may further impact their optical properties.It is therefore necessary to accurately characterize the overall properties of SSA particles carrying organic coatings due to condensing fatty acid vapor to reveal their overall impact on climate. 展开更多
关键词 Sea spray aerosol Organic coating Fatty acid Light scattering Complex refractive index
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Short-chain fatty acids mediate enteric and central nervous system homeostasis in Parkinson’s disease:Innovative therapies and their translation 认领 引用 被引量：3
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作者 Shimin Pang Zhili Ren +1 位作者 Hui Ding Piu Chan 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第3期938-956,共19页
Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’... Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease. 展开更多
关键词 alpha-synuclein blood-brain barrier blood circulation central nervous system endocrine enteric nervous system glial cell gut-brain axis gut microbiota intestinal barrier neuron Parkinson’s disease short chain fatty acids vagus nerve
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Antibiotic-sensitive gut symbiont Turicibacter sanguinis alleviates constipation by enhancing short-chain fatty acids and tryptophan metabolism 认领 引用
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作者 Ruocen Tian Xinyue Hu +4 位作者 Leilei Yu Fengwei Tian Jianxin Zhao Qixiao Zhai Wei Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3104-3115,共12页
Turicibacter sanguinis is a prominent genus within the mammalian gut microbiota and is associated with various metabolic and gastrointestinal disorders,including overweight,obesity,irritable bowel syndrome(IBS)and con... Turicibacter sanguinis is a prominent genus within the mammalian gut microbiota and is associated with various metabolic and gastrointestinal disorders,including overweight,obesity,irritable bowel syndrome(IBS)and constipation.However,the specific roles of T.sanguinis in host physiology remain unclear.In this study,antibiotic intervention experiments in mice revealed that T.sanguinis abundance was significantly reduced by intervention with sisomicin sulfate,ribostamycin sulfate,and cefadroxil,providing a T.sanguinis-depleted model for further investigations.By analyzing 6040 gut metagenomes,we observed an enrichment of T.sanguinis in IBS patients,while its abundance was significantly decreased in individuals with constipation.Next,using a T.sanguinis-depleted mouse model,we further validated the functional role of T.sanguinis in alleviating loperamide-induced constipation.Analysis of short-chain fatty acid(SCFA)and metabolomics revealed that T.sanguinis supplementation increased the levels of butyrate and isobutyrate in the colon and enhanced tryptophan metabolism,particularly elevating 5-hydroxytryptamine(5-HT)levels in intestinal tissue.Together,our findings identify T.sanguinis as a microbial mediator in antibiotic-associated constipation and offer new insights into microbiota-targeted therapies for functional gastrointestinal disorders. 展开更多
关键词 Gut microbiota Turicibacter sanguinis Constipation Antibiotic Short-chain fatty acid 5-Hydroxytryptamine
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Fatty acids in breast milk during lactation in Ateles geoffroyi offspring in managed care and semi-free-ranging 认领 引用
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作者 Ma de Jesús Rovirosa-Hernández María Remedios Mendoza-López +4 位作者 Manuel Alejandro Cruz Aguilar Juan Francisco Rodríguez-Landa Mario Caba Rael M.Palestino-Sánchez Francisco García-Orduña 《Current Zoology》 SCIE CAS CSCD 2026年第1期147-151,共5页
long-chain polyunsaturated fatty acids,maternal diet,spider monkeys,weaning behavior Long-chain polyunsaturated fatty acids(LC-PUFAs)are precursors of omega-3 and omega-6,which are considered essential fatty acids(EFA... long-chain polyunsaturated fatty acids,maternal diet,spider monkeys,weaning behavior Long-chain polyunsaturated fatty acids(LC-PUFAs)are precursors of omega-3 and omega-6,which are considered essential fatty acids(EFA),for pre-and post-natal neural development of several species including non-human primates(NHPs),(Hornstra 2000;Milligan and Bazinet 2008).The deficiency of these EFA can provoke growth retardation(Burr and Burr 1929),behavioral changes(Reisbick et al.1994)and motor skill(Champoux et al.2002). 展开更多
关键词 long-chain polyunsaturated fatty acids maternal diet spider monkeys weaning behavior
Alternate wetting and moderate drying irrigation improves rice cooking and eating quality by optimizing lipid and fatty acid synthesis in grains 认领 引用
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作者 Yunji Xu Xuelian Weng +7 位作者 Shupeng Tang Xiufeng Jiang Weiyang Zhang Kuanyu Zhu Guanglong Zhu Hao Zhang Zhiqin Wang Jianchang Yang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第1期68-80,共13页
Alternate wetting and drying irrigation(AWD)significantly influences the cooking and eating quality of rice(Oryza sativa L.).However,the mechanisms by which AWD affects rice cooking and eating quality remain unclear.L... Alternate wetting and drying irrigation(AWD)significantly influences the cooking and eating quality of rice(Oryza sativa L.).However,the mechanisms by which AWD affects rice cooking and eating quality remain unclear.Lipid and free fatty acid contents in grains correlate positively with cooking and eating quality of rice.This study examined Yangdao 6(YD6,a conventional taste indica inbred)and Nanjing 9108(NJ9108,a superior taste japonica inbred)cultivated under conventional irrigation(CI),alternate wetting and moderate drying irrigation(AWMD),and alternate wetting and severe drying irrigation(AWSD)from 10 days after transplanting to maturity.The research investigated the relationship between lipid and free fatty acid biosynthesis in grains and the cooking and eating quality of rice.Compared to CI treatment,AWMD significantly enhanced the contents of lipid,total free fatty acids(TFFAs),free unsaturated fatty acids(FUFAs),linoleic acid,and oleic acid in milled rice by increasing activities of enzymes associated with lipid synthesis,while AWSD produced opposite effects.Correlation analysis revealed that elevated levels of lipid,TFFAs,FUFAs,linoleic acid,and oleic acid contribute to improved rice cooking and eating quality.The findings demonstrate that AWMD enhances cooking and eating quality of milled rice through optimization of lipid and fatty acid synthesis in rice grains. 展开更多
关键词 rice(Oryza sativa L.) cooking and eating quality lipid content fatty acid content alternate wetting and drying irrigation
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Rumen unprotected glucose tends to promote intramuscular fat deposition via microbial volatile fatty acid-mediated metabolic reprogramming in cattle:a multi-omics perspective through the rumen-jejunum axis 认领 引用
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作者 Yang Song Ning Liu +6 位作者 Zan Liang Zuo Wang Tingting Chu Qianglin Liu Weijun Shen Xiangmin Yan Fachun Wan 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第4期2310-2336,共27页
Background The regulatory effects of glucose absorption at different sites(rumen vs.small intestine)on lipid metabolism exhibit significant variation in beef nutrition.This study aimed to investigate the regulatory pa... Background The regulatory effects of glucose absorption at different sites(rumen vs.small intestine)on lipid metabolism exhibit significant variation in beef nutrition.This study aimed to investigate the regulatory pathways of rumenprotected or unprotected glucose on lipid metabolism through the rumen-jejunum axis in Xinjiang Brown cattle.Results Thirty Xinjiang Brown cattle(females)with similar initial weight(410±22.4 kg)were randomly assigned to 3treatment groups(n=10 animals per group).The experimental groups were fed a basal diet with the following daily supplements per head:150 g palmitate coating(CON group),150 g palmitate coating plus 150 g rumen-unprotected glucose(RUG group),and 300 g rumen-protected glucose(containing 50%glucose;RPG group).The experiment lasted for 70 d.Supplementation with both rumen-unprotected glucose and rumen-protected glucose increased chest width(P=0.001),chest girth(P=0.013),abdominal girth(P=0.002),backfat thickness(P=0.041),omental fat weight(P=0.047),as well as serum concentrations of insulin(P0.05),but the differential bacterial biomarkers were either positively or negatively correlated with chest girth,abdominal girth,marbling score,backfat thickness,and deoxycholic acid(P<0.05).Conclusion Rumen-unprotected glucose supplementation enhances IMF deposition and meat quality attributes through microbial volatile fatty acid-driven metabolic reprogramming. 展开更多
关键词 Lipid deposition Rumen-jejunum axis Rumen-unprotected glucose Rumen-protected glucose Volatile fatty acids
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Effects of omega-3 fatty acid supplementation on heart rate variability 认领 引用
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作者 Hoda Atef Abdelsattar Ibrahim Kamal Gouda Kamal +3 位作者 Mohamed Khaled Ali Mohamed Ali Zid Albraa Ashraf Hamad Ayesha Kuraishi Marwa Taha 《World Journal of Clinical Pediatrics》 2026年第1期313-322,共10页
BACKGROUND Obesity and overweight are major public health challenges and are associated with autonomic imbalance and decreased heart rate variability(HRV),a noninvasive indicator of cardiovascular risk.Omega-3 polyuns... BACKGROUND Obesity and overweight are major public health challenges and are associated with autonomic imbalance and decreased heart rate variability(HRV),a noninvasive indicator of cardiovascular risk.Omega-3 polyunsaturated fatty acids have shown cardioprotective effects and may modulate autonomic function.Nevertheless,the effect of omega-3 supplementation on HRV in individuals who are overweight or obese remains unclear.AIM To study the effect of omega-3 supplementation on HRV in overweight and obese individuals and to explore the heterogeneity across different study designs.METHODS In accordance with PRISMA guidelines,a systematic review and meta-analysis were conducted.PubMed,Science Citation Index,and Scopus were searched for randomized controlled trials(RCTs)assessing the impact of oral omega-3 supplementation on HRV in overweight or obese participants.Primary outcomes were the impacts of omega-3 supplementation on time-domain HRV indices[root mean square of successive differences(RMSSD),standard deviation of normal-tonormal intervals(SDNN),and percentage of successive normal-to-normal intervals differing by more than 50 milliseconds(pNN50%)],and frequency-domain indices[high-frequency(HF)power,low-frequency(LF)power,and LF/HF ratio].RESULTS Four RCTs(n=134 participants)met the inclusion criteria.Two trials compared pre-vs post-omega-3 supplementation,and two compared omega-3 with placebo on HRV in overweight and obese children and adults.In the within-subject analyses,omega-3 supplementation was associated with a significant increase in RMSSD[mean difference(MD)=-11.69 milliseconds,95%CI:-18.50 to-4.87,P=0.0008],SDNN(MD=-26.13 milliseconds,95%CI:-35.84 to-16.42,P<0.00001),and pNN50%(MD=-9.45,95%CI:-14.27 to-4.64,P=0.0001).Between-group comparisons showed that omega-3 supplementation had no significant effect on HF power,LF power,or the LF/HF ratio.CONCLUSION Omega-3 supplementation represents a promising and low-cost strategy for enhancing autonomic balance and potentially reducing cardiovascular risk in overweight and obese populations,as it improves time-domain HRV measures. 展开更多
关键词 Autonomic nervous system Heart rate variability Meta-analysis Obesity Omega-3 polyunsaturated fatty acids Randomized controlled trials
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Royal jelly fatty acids as emerging anticancer agents:integrative mechanisms and translational perspectives 认领 引用
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作者 Jie Yi Isack Ibrahim Mrisho +3 位作者 Elshan Musazade Wei Li Jiahong Han Enbo Cai 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3052-3068,共17页
Royal jelly(RJ),a nutrient-rich secretion from the hypopharyngeal and mandibular glands of worker bees(Apis mellifera),has gained significant attention as a natural source of bioactive compounds with therapeutic poten... Royal jelly(RJ),a nutrient-rich secretion from the hypopharyngeal and mandibular glands of worker bees(Apis mellifera),has gained significant attention as a natural source of bioactive compounds with therapeutic potential.Among its various constituents,medium-chain fatty acids(MCFAs),notably 10-hydroxy-2-decenoic acid(10-HDA),10-hydroxydecanoic acid(10-HDAA),and sebacic acid(SA),exhibit potent antioxidant,antiinflammatory,immunomodulatory,and antimicrobial properties.In recent years,10-HDA has emerged as the primary anticancer agent in RJ,demonstrating the ability to modulate key oncogenic pathways,including the induction of apoptosis,cell cycle arrest,and inhibition of angiogenesis and metastasis.This review provides a comprehensive analysis of the chemical composition,biosynthetic origin,and extraction techniques of RJ fatty acids(RJFAs),with a critical focus on their molecular mechanisms of anticancer action,including modulation of cell signaling pathways,DNA repair mechanisms,and immune response.We further explore their metabolic stability,bioavailability,and synergistic potential with conventional chemotherapeutics in models of lung cancer,breast cancer,liver cancer,and melanoma.Although promising,current limitations,including challenges in standardization,pharmacokinetics,and formulation,warrant further investigation.Future directions emphasize omics-driven approaches,such as genomics,proteomics,and metabolomics,as well as translational research to optimize the clinical applicability of RJFAs.Collectively,these insights position RJFAs,particularly 10-HDA,as compelling candidates for adjunctive cancer therapy and integrative oncology. 展开更多
关键词 Royal jelly fatty acids 10-Hydroxy-2-decenoic acid 10-Hydroxydecanoic acid Anticancer mechanisms Integrative oncology Natural bioactive compounds
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Long-chain Fatty Acids in Atherosclerosis:Focus on Metabolites and Mechanisms 认领 引用
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作者 PAN Jin-Qian LIU Wang +2 位作者 LI Zhao-Bing LIU Shi-Yang ZHOU Qin-Yi 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2026年第7期1826-1848,共23页
Atherosclerosis(AS)remains the core pathological basis underlying the high incidence and high rates of mortality and disability associated with cardiovascular disease(CVD)worldwide.Its essence is not merely lipid depo... Atherosclerosis(AS)remains the core pathological basis underlying the high incidence and high rates of mortality and disability associated with cardiovascular disease(CVD)worldwide.Its essence is not merely lipid deposition,but rather an immunemediated disease of the vascular wall characterized by an interplay of lipid metabolism disorders and chronic inflammation,with damage to vascular endothelial cells serving as the initiating event.As the disease progresses,it involves complex synergistic interactions among various cellular components,including endothelial cells,macrophages,and inflammatory cells,ultimately leading to plaque formation,instability,and even fatal thrombotic events.In recent years,the central driving role of lipid metabolic reprogramming in the progression of AS has garnered increasing attention from the scientific community.Among the vast array of lipid molecules,long-chain fatty acids(LCFAs)have become a primary focus of research due to their exceptional physiological functions.Traditional views have primarily emphasized the basic physiological functions of LCFAs:serving as highly efficient energy substrates through mitochondrialβ-oxidation and acting as key structural components of cellular phospholipid membranes.However,emerging evidence clearly indicates that the functions of LCFAs extend far beyond those of mere metabolic fuel.They also act as potent bioactive signaling molecules,playing an indispensable multidimensional role in the pathogenesis of AS.Equally noteworthy and representing a paradigm shift in cardiovascular research is the emerging theory of the“gut-heart axis”.This theoretical framework views the human gut microbiota—comprising trillions of microorganisms—as a critical and metabolically active“bioreactor”.A wealth of clinical and multi-cohort epidemiological studies have conclusively demonstrated that imbalances in the composition and function of the gut microbiota are highly correlated with the clinical risk and severity of AS.Within this axis,the gut microbiota serves as the primary processing hub for dietary lipids.It actively participates in the digestion and biochemical remodeling of LCFAs,thereby altering their saturation and chemical structure and generating a wide variety of gut microbial metabolites.The effects of these gut-derived lipid metabolites extend far beyond the local intestinal microenvironment.Upon entering the bloodstream,these circulating microbiota metabolites act as endocrine signals.Given the extreme complexity of the underlying mechanisms,a comprehensive elucidation of the synergistic and bidirectional interactions between LCFAs and the gut microbiota in vascular pathology is particularly urgent.Therefore,this article aims to provide a systematic review of the multidimensional regulatory mechanisms of LCFAs and their associated gut microbiota metabolites in the onset,progression,and clinical manifestations of AS.By thoroughly exploring the interaction patterns within the“LCFAs-gut microbiota-AS”triad,this review seeks to fundamentally expand our understanding of the pathogenesis of CVDs.More importantly,translating these mechanistic insights into clinical practice holds tremendous promise.We hope to provide a solid theoretical foundation for the future development of novel AS prevention and treatment strategies based on non-traditional approaches.These include precision nutritional interventions(i.e.,dietary lipid intake plans tailored to an individual’s unique microbiome profile)and targeted microbiome modulation therapies(such as next-generation probiotics,prebiotics,or specific metabolite supplements).Targeting the gut as a“reactor”to treat vascular wall lesions represents a promising direction for future cardiovascular medicine. 展开更多
关键词 long-chain fatty acid atherosclerosis gut microbiota metabolite
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