Tuberculosis(TB)is a chronic infectious disease caused by Mycobacterium tuberculosis(MTB)that severely endangers human health.Despite significant progress in global TB control,TB remains one of the top ten causes of d...Tuberculosis(TB)is a chronic infectious disease caused by Mycobacterium tuberculosis(MTB)that severely endangers human health.Despite significant progress in global TB control,TB remains one of the top ten causes of death worldwide.In its 2025 report,the World Health Organization(WHO)estimated 10.7 million new TB cases globally,with 1.23 million deaths.Early detection and treatment of TB are crucial for TB control.Community-based active case finding(ACF)is an active case detection strategy that is incorporated as a core component of Pillar 1 of the End TB Strategy and has demonstrated effectiveness in high-burden settings.展开更多
Incidental findings are increasingly common in radiology yet reporting and follow-up remain inconsistent.We introduce Incidental-Reporting and Data System(I-RADS)as a classification system across imaging modalities an...Incidental findings are increasingly common in radiology yet reporting and follow-up remain inconsistent.We introduce Incidental-Reporting and Data System(I-RADS)as a classification system across imaging modalities and anatomical regions.I-RADS aims to improve communication among physicians,standardize recommendations,and promote research.Along with preexisting tools and guidelines,adoption of I-RADS could harmonize the management of incidental findings,improve patient outcomes,and support multicenter studies.展开更多
This paper proposes a three-dimensional(3D)interferometer direction-finding(DF)method to address the reduced accuracy of conventional two-dimensional(2D)interferometer DF methods in non-planar antenna configurations.F...This paper proposes a three-dimensional(3D)interferometer direction-finding(DF)method to address the reduced accuracy of conventional two-dimensional(2D)interferometer DF methods in non-planar antenna configurations.First,we enhance the multi-channel soft synchronization(MCSS)technique by dynamically compensating for sampling point offsets,achieving phase estimation accuracy better than 0.01 sampling points.Second,we construct a 3D baseline model based on the 3D distribution characteristics of the antennas and introduce a 3D error allocation model to improve the system error estimation method,allowing for dynamic correction of calibration deviations.This effectively addresses the phase ambiguity issues caused by 3D mechanical errors.Finally,we develop a 3D DF algorithm and an optimized multi-pulse fusion approach utilizing the maximum-ratio combining(MFA-MRC)method to reduce DF errors and enhance system stability.Simulation experiments and flight tests demonstrate that the proposed method has a computational load of only 0.31%of the multiple signal classification(MUSIC)algorithm.When the baseline offset exceeds 10 mm,the angular accuracy improves from 0.9°to 0.3°,and the positioning accuracy is enhanced from approximately 10 km to around 1 km.The study holds significant theoretical and practical value in engineering.展开更多
Dear Editor,Herein,we report multimodal imaging findings in three cases of focal scleral nodule(FSN).The term“unifocal helioid choroiditis”was initially proposed by Hong[1]in 1997 to describe idiopathic solitary cho...Dear Editor,Herein,we report multimodal imaging findings in three cases of focal scleral nodule(FSN).The term“unifocal helioid choroiditis”was initially proposed by Hong[1]in 1997 to describe idiopathic solitary choroidal lesions in 6 cases.In 2002,Shields et al[2]reported 60 similar cases,coining the term“solitary idiopathic choroiditis”.With the advent of enhanced depth imaging optical coherence tomography(EDI-OCT),these lesions were shown to arise in the sclera rather than the choroid.A 2020 multicenter study proposed renaming solitary idiopathic choroiditis as FSN based on multimodal imaging observations including EDI-OCT in 63 cases[3].展开更多
BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is an uncom-mon and highly aggressive form of lymphoma that represents less than 1%of all non-Hodgkin’s lymphomas.At present,few reports have fo...BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is an uncom-mon and highly aggressive form of lymphoma that represents less than 1%of all non-Hodgkin’s lymphomas.At present,few reports have focused on the imaging findings of MEITL,which poses significant challenges for clinical diagnosis.A 78-year-old female with recurrent vomiting and abdominal distension was admitted to our hospital.Magnetic resonance and18F-fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)examinations revealed multiple segmental malignant tumors in the small intestine with me-senteric lymph node metastasis.An endoscopic biopsy revealed MEITL.After three cycles of reduced-dose cyclophosphamide,vinorelbine,and prednisone che-motherapy,follow-up18F-FDG PET/CT demonstrated a partial response to treatment.The patient was still alive after 6 months of follow-up.CONCLUSION Magnetic resonance imaging serves as a valuable tool in detecting malignant tumor lesions of MEITL,whereas18F-FDG PET/CT offers additional assistance in tumor staging and assessing treatment efficacy.展开更多
Electronic reconnaissance units commonly utilize an interferometer direction-finding system to measure the incoming direction of radar radiation signals.This approach enables the accurate determination of threat sourc...Electronic reconnaissance units commonly utilize an interferometer direction-finding system to measure the incoming direction of radar radiation signals.This approach enables the accurate determination of threat source locations,which is essential for devising route plans oriented toward flight path generation.When a frequency diverse array(FDA)system is adopted by ground radars,errors are introduced into the angle measurements of the passive direction finding system.To address this issue,this study starts with FDA model establishment and equiphasic surface characteristics analysis and analyzes the principles of FDA deception in identifying one-dimensional single-baseline interferometer directions.Additionally,the Cramer-Rao bounds of the signal carrier frequency estimation error and angle measurement error during the interferometer’s direction finding process are considered.The simulation results verify that the one-dimensional single-baseline interferometer direction finding system can be deceived by the FDA radar,and the FDA with a sine frequency offset exhibits the optimum deception effect.展开更多
According to the measurement principle of the traditional interferometer,a narrowband signal model is established and used,however,for wideband signals or multiple signals,this model is invalid.For the problems of dir...According to the measurement principle of the traditional interferometer,a narrowband signal model is established and used,however,for wideband signals or multiple signals,this model is invalid.For the problems of direction finding with interferometer for wideband signals and multiple signals scene,a frequency domain phase interferometer is proposed and the concrete implementation scheme is given.The proposed method computes the phase difference in frequency domain,and finds multi-target results with judging the spectrum amplitude changing,and uses the frequency phase difference to compute the arrival angle.Theoretical analysis and simulation results show that the proposed method effectively solves the problem of the angle estimation with phase interferometer for wideband signals,and has good performance in multiple signals scene with nonoverlapping spectrum or partially overlapping.In addition,the wider the signal bandwidth,the better direction finding performance of this algorithm.展开更多
Background GW117(N-(2-(6-chloro-7-deuteromethoxynaphthalen-1-yl)ethyl)acetamide)is a dual-acting agent(MT1/MT2 agonist,5-HT2Cantagonist)with prior evidence of antidepressant efficacy and favourable safety.Aims To p...Background GW117(N-(2-(6-chloro-7-deuteromethoxynaphthalen-1-yl)ethyl)acetamide)is a dual-acting agent(MT1/MT2 agonist,5-HT2Cantagonist)with prior evidence of antidepressant efficacy and favourable safety.Aims To preliminarily evaluate the efficacy and safety of GW117 in major depressive disorder(MDD)and to explore the optimal dosing.Methods A total of 280 eligible patients aged 18-65years with MDD were randomly assigned(1:1:1:1)to8 weeks of double-blind treatment with fixed doses of GW117 tablets(20,40,60 mg/day)or placebo.The primary endpoint was the change from baseline to Week 8 in the total score of the Hamilton Rating Scale for Depression-17item(HAMD-17).Key secondary endpoints included changes in the Montgomery-?sberg Depression Rating Scale(MADRS)total score over the same period.Results In the full analysis set(n=276),GW117 showed numerically greater reductions versus placebo in the HAMD-17 and MADRS total scores,as well as higher response rates at Week 8.However,these differences did not reach statistical significance,potentially due to a high placebo response and other contributing factors.In a post hoc analysis of an optimal subgroup(baseline HAMD-17>24 or insomnia factor>4),GW117 showed efficacy in improving multidimensional symptoms,including insomnia.The 20 mg dose demonstrated a significant3.66-point greater reduction in MADRS(p=0.026)and a23.16%higher response rate(p=0.013)compared with placebo.GW117 was well-tolerated,with no cases of alanine aminotransferase or aspartate aminotransferase exceeding 3×the upper limit of normal and no concerning safety signals reported.Conclusions This exploratory study found that GW117demonstrated encouraging antidepressant efficacy and a favourable safety profile in patients with MDD.Although differences versus placebo did not reach statistical significance in the overall population,GW11720 mg monotherapy showed significant improvements in multidimensional depressive symptoms,including insomnia,in the optimal response subgroup.No hepatotoxicity was reported,supporting its promising therapeutic potential for further clinical development.展开更多
Reconstructing the trajectories of charged particles in high-energy physics experiments is a complex task,particularly for long-lived particles.At the future Super Tau-Charm Facility(STCF),such particles are expected ...Reconstructing the trajectories of charged particles in high-energy physics experiments is a complex task,particularly for long-lived particles.At the future Super Tau-Charm Facility(STCF),such particles are expected to appear in several key benchmark physics processes.A Common Tracking Software was used to reconstruct the trajectories of long-lived particles,revealing that the track-finding performance of the widely used combinatorial Kalman filter is limited by its seeding algorithm.This limitation can be mitigated by guiding the combinatorial Kalman filter using initial tracks provided by the Hough transform.The track-finding performance of the combined Hough transform and combinatorial Kalman filter was evaluated using the process J∕ψ→Λ(→pπ−)Λ(→pπ+)at STCF.展开更多
BACKGROUND Crohn’s disease(CD)patients with intestinal involvement often require surgical intervention due to resistance to medical therapy.Postoperative recurrence remains a significant challenge,with the Rutgeerts ...BACKGROUND Crohn’s disease(CD)patients with intestinal involvement often require surgical intervention due to resistance to medical therapy.Postoperative recurrence remains a significant challenge,with the Rutgeerts score commonly used to predict endoscopic recurrence.AIM To evaluate the relationship between microscopic and macroscopic pathological findings in resected intestinal specimens and the Rutgeerts score to predict endoscopic recurrence in CD patients.METHODS This retrospective cohort study included 32 patients over 18 years of age with intestinal CD who underwent surgery at General Surgery Clinic of Ankara Bilkent City Hospital between November 2019 and October 2023.Resection specimens were histopathologically re-examined,and postoperative colonoscopy reports were classified according to the Rutgeerts score.The association between pathological findings and endoscopic recurrence was analyzed statistically.RESULTS No significant association was found between macroscopic findings and Rutgeerts scores or endoscopic recurrence(P>0.05).However,the presence and severity of neutrophilic cryptitis(P=0.035)and crypt abscesses(P=0.010)in microscopic findings were significantly associated with higher Rutgeerts scores,indicating a parallel increase with endoscopic recurrence.Other microscopic findings showed no significant correlation with Rutgeerts scores or endoscopic recurrence(P>0.05).CONCLUSION The presence of neutrophilic cryptitis and crypt abscesses in resected intestinal specimens of CD patients increases the likelihood of endoscopic recurrence.Early postoperative medical treatment and close endoscopic follow-up may benefit high-risk patients to prevent recurrence,with treatment decisions made by a weekly multidisciplinary council involving General Surgery,Gastroenterology,and Radiology.展开更多
AIM:To analyze the ocular findings of patients who received lifelong leptin therapy due to congenital leptin deficiency(CLD),an extremely rare condition.METHODS:A prospective,cross-sectional comparative study was perf...AIM:To analyze the ocular findings of patients who received lifelong leptin therapy due to congenital leptin deficiency(CLD),an extremely rare condition.METHODS:A prospective,cross-sectional comparative study was performed on six patients with CLD and 13 healthy age-and sex-matched controls.The central corneal thickness(CCT),anterior chamber depth(ACD),axial length(AL),keratometry(K1,K2),optical coherence tomography(OCT),and OCT angiography parameters were compared between the leptin and control groups at the baseline visit.The change in these measurements in leptin patients over a two-year period was analyzed.RESULTS:CLD patients had lower mean AL,ACD,and CCT(P≤0.012 for all).Mean K1,K2(P≤0.047 for both),choroidal thickness(P≤0.001),and central ganglion cell layer(GCL)thickness(P=0.029)were higher in the leptin group.Perifoveal superficial capillary plexus(SCP)density was decreased in all quadrants except the temporal region(P<0.05),and parafoveal deep capillary plexus(DCP)density was decreased in the superior hemisphere,temporal quadrant(P≤0.036 for both)and nasal quadrant(P=0.048)in the leptin group.During the two-year follow-up,no changes in anterior and posterior segment measurements were observed in the leptin patients,except for subfoveal choroidal thickness(P<0.001).CONCLUSION:CLD patients exhibit structural alterations in both the anterior and posterior segments of the eye,including notable changes in retinal and choroidal vasculature.However,there is limited evidence concerning the influence of leptin therapy on the eye.展开更多
BACKGROUND Immunoglobulin A(IgA)vasculitis,formerly known as Henoch-Schönlein purpura,is a small vessel vasculitis predominantly affecting children.It commonly presents with a triad of purpuric rash,arthralgia,an...BACKGROUND Immunoglobulin A(IgA)vasculitis,formerly known as Henoch-Schönlein purpura,is a small vessel vasculitis predominantly affecting children.It commonly presents with a triad of purpuric rash,arthralgia,and abdominal pain.However,dermatologic manifestations of IgA vasculitis in black-skinned individuals are poorly documented in literature.CASE SUMMARY This case report describes an 11-year-old black girl with acute onset of rash,joint pain,and abdominal pain,subsequently diagnosed with IgA vasculitis.CONCLUSION The case highlights the importance of early recognition and supportive management in ensuring a favorable outcome,particularly in dark-skinned populations.展开更多
To quantify physicians'risk and time preferences and explore the association between the preferences and their willingness to detect and disclose secondary findings(SFs)derived from genome-scale sequencing.We desi...To quantify physicians'risk and time preferences and explore the association between the preferences and their willingness to detect and disclose secondary findings(SFs)derived from genome-scale sequencing.We designed a webbased survey incorporating a multiple price list(MPL)as the instrument for risk and time preference measurement.The estimation was under the expected utility theory(EUT)and rank dependent utility(RDU)frameworks,respectively.The isoelastic and power function utility models were applied.We received responses from 87 physicians,among whom 46 completed the questionnaire(a completion rate of 52.9%).We observed positive risk-aversion coefficients under EUT(0.33,95%CI 0.15-0.51)and RDU(0.51,95%CI 0.32-0.71),suggesting that physicians were generally risk-averse.Respondents were likely to underestimate probabilities of low to moderate levels,and slightly overestimate high-level probabilities.Physicians supporting the detection and disclosure of SFs had a larger risk-aversion coefficient and a smaller discounting parameter than the non-supporters,suggesting that they were more risk-averse and discounted future utility less.Assuming heterogeneous risk perception,we found respondents underestimated low/moderate risk and slightly overestimated high risk.This study indicates that physicians who are risk-averse and discount future utility slightly are willing to detect and return SFs.The findings contribute to the debate surrounding SF disclosure and generate implications for shared decision-making in clinical genome-scale sequencing.展开更多
To describe and analyze the current status of benefit-finding research in patients with chronic diseases and to provide a reference for clinical practice and future research in this field.Using Arksey and O’Malley’s...To describe and analyze the current status of benefit-finding research in patients with chronic diseases and to provide a reference for clinical practice and future research in this field.Using Arksey and O’Malley’s scoping review methodology as a framework,we searched PubMed,Web of Science,Science Direct,and CINAHL(4 English databases);and China National Knowledge Infrastructure,the VIP Database for Chinese Technical Periodicals,the Wan Fang Database and China Biomedical Database(4 Chinese databases)for literature on benefit finding in patients with chronic diseases,with a search time frame of construction to April 20,2024,and the literature was screened,extracted,and summarized.A total of 44 papers were included,comprising 18 in Chinese and 26 in English.Among them,a total of 19 assessment tools were used,and the influential factors investigated were categorized into socio-demographic characteristics,disease-related characteristics,psychological and behavioral characteristics,coping styles,and social support.Benefit finding is found to be a positive psychological experience and important for patients with chronic diseases,and the influencing factors are complex and diverse,with a wide range of assessment tools.However,domestic tools lack autonomy and specificity.Clinical caregivers and staff should develop relevant assessment tools and formulate a personalized research plan based on the characteristics of patients with chronic diseases in China to promote the adoption of healthy lifestyles by patients with chronic diseases,improve their self-management ability,and provide a practical basis for improving the quality of life of patients with chronic diseases.展开更多
Track finding is a complex optimization problem,originally introduced in particle physics for the reconstruction of the trajectories of particles.A track is typically composed of several consecutive segments,which tog...Track finding is a complex optimization problem,originally introduced in particle physics for the reconstruction of the trajectories of particles.A track is typically composed of several consecutive segments,which together form a smooth curve without any bifurcations.In this paper,we investigate various modeling approaches to assess their effectiveness and impact when applied to track finding,using both quantum and classical methods.We present implementations of three classical models using CPLEX,two quantum models on actual D-Wave quantum computers,and one quantummodel on a D-Wave simulator.The results show that,while CPLEX provides better results than D-Wave on small instances,D-Wave is able to propose solutions in shorter computation times for large instances,although the gap with the optimal solution tends to increase.To the best of our knowledge,this is the first numerical study comparing a non-quantum approach based on classical algorithms(Simplex and Branch and Bound)used in commercial software with a quantum approach offered by D-Wave.The results do not show the quantum supremacy typically expected,but they do demonstrate that quantum solutions can be competitive with classical approaches,and even more efficient than some classical modeling and solving methods.展开更多
Colorectal cancer ranks third in incidence worldwide but second in mortality(1).In China,colorectal cancer is the second most common cancer and the most prevalent gastrointestinal malignancy,with both incidence and mo...Colorectal cancer ranks third in incidence worldwide but second in mortality(1).In China,colorectal cancer is the second most common cancer and the most prevalent gastrointestinal malignancy,with both incidence and mortality continuing to rise(2).In 2017,the Chinese Society of Clinical Oncology(CSCO)issued its guidelines for colorectal cancer.These guidelines are updated annually to incorporate the latest clinical research findings,therapeutic agents,and expert opinions(3-8).This article describes the updates made in the 2026 version compared with the 2025 version.展开更多
基金supported by the People's Government of Quzhou,which provided special funds for private practical affairs(2021),the Capital Medical University Discipline Construction Funding(0300-123001)the Beijing Municipal Education Commission's New Teacher Aid Project(XJJS202516).
摘要Tuberculosis(TB)is a chronic infectious disease caused by Mycobacterium tuberculosis(MTB)that severely endangers human health.Despite significant progress in global TB control,TB remains one of the top ten causes of death worldwide.In its 2025 report,the World Health Organization(WHO)estimated 10.7 million new TB cases globally,with 1.23 million deaths.Early detection and treatment of TB are crucial for TB control.Community-based active case finding(ACF)is an active case detection strategy that is incorporated as a core component of Pillar 1 of the End TB Strategy and has demonstrated effectiveness in high-burden settings.
摘要Incidental findings are increasingly common in radiology yet reporting and follow-up remain inconsistent.We introduce Incidental-Reporting and Data System(I-RADS)as a classification system across imaging modalities and anatomical regions.I-RADS aims to improve communication among physicians,standardize recommendations,and promote research.Along with preexisting tools and guidelines,adoption of I-RADS could harmonize the management of incidental findings,improve patient outcomes,and support multicenter studies.
摘要This paper proposes a three-dimensional(3D)interferometer direction-finding(DF)method to address the reduced accuracy of conventional two-dimensional(2D)interferometer DF methods in non-planar antenna configurations.First,we enhance the multi-channel soft synchronization(MCSS)technique by dynamically compensating for sampling point offsets,achieving phase estimation accuracy better than 0.01 sampling points.Second,we construct a 3D baseline model based on the 3D distribution characteristics of the antennas and introduce a 3D error allocation model to improve the system error estimation method,allowing for dynamic correction of calibration deviations.This effectively addresses the phase ambiguity issues caused by 3D mechanical errors.Finally,we develop a 3D DF algorithm and an optimized multi-pulse fusion approach utilizing the maximum-ratio combining(MFA-MRC)method to reduce DF errors and enhance system stability.Simulation experiments and flight tests demonstrate that the proposed method has a computational load of only 0.31%of the multiple signal classification(MUSIC)algorithm.When the baseline offset exceeds 10 mm,the angular accuracy improves from 0.9°to 0.3°,and the positioning accuracy is enhanced from approximately 10 km to around 1 km.The study holds significant theoretical and practical value in engineering.
摘要Dear Editor,Herein,we report multimodal imaging findings in three cases of focal scleral nodule(FSN).The term“unifocal helioid choroiditis”was initially proposed by Hong[1]in 1997 to describe idiopathic solitary choroidal lesions in 6 cases.In 2002,Shields et al[2]reported 60 similar cases,coining the term“solitary idiopathic choroiditis”.With the advent of enhanced depth imaging optical coherence tomography(EDI-OCT),these lesions were shown to arise in the sclera rather than the choroid.A 2020 multicenter study proposed renaming solitary idiopathic choroiditis as FSN based on multimodal imaging observations including EDI-OCT in 63 cases[3].
基金Supported by the National Natural Science Foundation of China,No.82160330the Science and Technology Program of the Health Commission of Jiangxi Province,No.2025110045+1 种基金the Ganzhou Science and Technology Planning Project,No.GZ2024YLJ016,No.GZ2024YLJ026,and No.GZ2024ZSF064the Ganzhou Health Commission Scientific Research Planning Project,No.GZWJW202402108.
摘要BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is an uncom-mon and highly aggressive form of lymphoma that represents less than 1%of all non-Hodgkin’s lymphomas.At present,few reports have focused on the imaging findings of MEITL,which poses significant challenges for clinical diagnosis.A 78-year-old female with recurrent vomiting and abdominal distension was admitted to our hospital.Magnetic resonance and18F-fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)examinations revealed multiple segmental malignant tumors in the small intestine with me-senteric lymph node metastasis.An endoscopic biopsy revealed MEITL.After three cycles of reduced-dose cyclophosphamide,vinorelbine,and prednisone che-motherapy,follow-up18F-FDG PET/CT demonstrated a partial response to treatment.The patient was still alive after 6 months of follow-up.CONCLUSION Magnetic resonance imaging serves as a valuable tool in detecting malignant tumor lesions of MEITL,whereas18F-FDG PET/CT offers additional assistance in tumor staging and assessing treatment efficacy.
基金supported by the National Natural Science Foundation of China Youth Fund Support Project(61503408)Shaanxi Provincial Association for Science and Technology Youth Talent Support Program Project(20230137)Shaanxi Provincial Natural Science Basic Research Program General Project(2023JCYB509).
摘要Electronic reconnaissance units commonly utilize an interferometer direction-finding system to measure the incoming direction of radar radiation signals.This approach enables the accurate determination of threat source locations,which is essential for devising route plans oriented toward flight path generation.When a frequency diverse array(FDA)system is adopted by ground radars,errors are introduced into the angle measurements of the passive direction finding system.To address this issue,this study starts with FDA model establishment and equiphasic surface characteristics analysis and analyzes the principles of FDA deception in identifying one-dimensional single-baseline interferometer directions.Additionally,the Cramer-Rao bounds of the signal carrier frequency estimation error and angle measurement error during the interferometer’s direction finding process are considered.The simulation results verify that the one-dimensional single-baseline interferometer direction finding system can be deceived by the FDA radar,and the FDA with a sine frequency offset exhibits the optimum deception effect.
摘要According to the measurement principle of the traditional interferometer,a narrowband signal model is established and used,however,for wideband signals or multiple signals,this model is invalid.For the problems of direction finding with interferometer for wideband signals and multiple signals scene,a frequency domain phase interferometer is proposed and the concrete implementation scheme is given.The proposed method computes the phase difference in frequency domain,and finds multi-target results with judging the spectrum amplitude changing,and uses the frequency phase difference to compute the arrival angle.Theoretical analysis and simulation results show that the proposed method effectively solves the problem of the angle estimation with phase interferometer for wideband signals,and has good performance in multiple signals scene with nonoverlapping spectrum or partially overlapping.In addition,the wider the signal bandwidth,the better direction finding performance of this algorithm.
摘要Background GW117(N-(2-(6-chloro-7-deuteromethoxynaphthalen-1-yl)ethyl)acetamide)is a dual-acting agent(MT1/MT2 agonist,5-HT2Cantagonist)with prior evidence of antidepressant efficacy and favourable safety.Aims To preliminarily evaluate the efficacy and safety of GW117 in major depressive disorder(MDD)and to explore the optimal dosing.Methods A total of 280 eligible patients aged 18-65years with MDD were randomly assigned(1:1:1:1)to8 weeks of double-blind treatment with fixed doses of GW117 tablets(20,40,60 mg/day)or placebo.The primary endpoint was the change from baseline to Week 8 in the total score of the Hamilton Rating Scale for Depression-17item(HAMD-17).Key secondary endpoints included changes in the Montgomery-?sberg Depression Rating Scale(MADRS)total score over the same period.Results In the full analysis set(n=276),GW117 showed numerically greater reductions versus placebo in the HAMD-17 and MADRS total scores,as well as higher response rates at Week 8.However,these differences did not reach statistical significance,potentially due to a high placebo response and other contributing factors.In a post hoc analysis of an optimal subgroup(baseline HAMD-17>24 or insomnia factor>4),GW117 showed efficacy in improving multidimensional symptoms,including insomnia.The 20 mg dose demonstrated a significant3.66-point greater reduction in MADRS(p=0.026)and a23.16%higher response rate(p=0.013)compared with placebo.GW117 was well-tolerated,with no cases of alanine aminotransferase or aspartate aminotransferase exceeding 3×the upper limit of normal and no concerning safety signals reported.Conclusions This exploratory study found that GW117demonstrated encouraging antidepressant efficacy and a favourable safety profile in patients with MDD.Although differences versus placebo did not reach statistical significance in the overall population,GW11720 mg monotherapy showed significant improvements in multidimensional depressive symptoms,including insomnia,in the optimal response subgroup.No hepatotoxicity was reported,supporting its promising therapeutic potential for further clinical development.
基金supported by the National Natural Science Foundation of China(Nos.12375194,12341504,12375197,12025502)。
摘要Reconstructing the trajectories of charged particles in high-energy physics experiments is a complex task,particularly for long-lived particles.At the future Super Tau-Charm Facility(STCF),such particles are expected to appear in several key benchmark physics processes.A Common Tracking Software was used to reconstruct the trajectories of long-lived particles,revealing that the track-finding performance of the widely used combinatorial Kalman filter is limited by its seeding algorithm.This limitation can be mitigated by guiding the combinatorial Kalman filter using initial tracks provided by the Hough transform.The track-finding performance of the combined Hough transform and combinatorial Kalman filter was evaluated using the process J∕ψ→Λ(→pπ−)Λ(→pπ+)at STCF.
摘要BACKGROUND Crohn’s disease(CD)patients with intestinal involvement often require surgical intervention due to resistance to medical therapy.Postoperative recurrence remains a significant challenge,with the Rutgeerts score commonly used to predict endoscopic recurrence.AIM To evaluate the relationship between microscopic and macroscopic pathological findings in resected intestinal specimens and the Rutgeerts score to predict endoscopic recurrence in CD patients.METHODS This retrospective cohort study included 32 patients over 18 years of age with intestinal CD who underwent surgery at General Surgery Clinic of Ankara Bilkent City Hospital between November 2019 and October 2023.Resection specimens were histopathologically re-examined,and postoperative colonoscopy reports were classified according to the Rutgeerts score.The association between pathological findings and endoscopic recurrence was analyzed statistically.RESULTS No significant association was found between macroscopic findings and Rutgeerts scores or endoscopic recurrence(P>0.05).However,the presence and severity of neutrophilic cryptitis(P=0.035)and crypt abscesses(P=0.010)in microscopic findings were significantly associated with higher Rutgeerts scores,indicating a parallel increase with endoscopic recurrence.Other microscopic findings showed no significant correlation with Rutgeerts scores or endoscopic recurrence(P>0.05).CONCLUSION The presence of neutrophilic cryptitis and crypt abscesses in resected intestinal specimens of CD patients increases the likelihood of endoscopic recurrence.Early postoperative medical treatment and close endoscopic follow-up may benefit high-risk patients to prevent recurrence,with treatment decisions made by a weekly multidisciplinary council involving General Surgery,Gastroenterology,and Radiology.
摘要AIM:To analyze the ocular findings of patients who received lifelong leptin therapy due to congenital leptin deficiency(CLD),an extremely rare condition.METHODS:A prospective,cross-sectional comparative study was performed on six patients with CLD and 13 healthy age-and sex-matched controls.The central corneal thickness(CCT),anterior chamber depth(ACD),axial length(AL),keratometry(K1,K2),optical coherence tomography(OCT),and OCT angiography parameters were compared between the leptin and control groups at the baseline visit.The change in these measurements in leptin patients over a two-year period was analyzed.RESULTS:CLD patients had lower mean AL,ACD,and CCT(P≤0.012 for all).Mean K1,K2(P≤0.047 for both),choroidal thickness(P≤0.001),and central ganglion cell layer(GCL)thickness(P=0.029)were higher in the leptin group.Perifoveal superficial capillary plexus(SCP)density was decreased in all quadrants except the temporal region(P<0.05),and parafoveal deep capillary plexus(DCP)density was decreased in the superior hemisphere,temporal quadrant(P≤0.036 for both)and nasal quadrant(P=0.048)in the leptin group.During the two-year follow-up,no changes in anterior and posterior segment measurements were observed in the leptin patients,except for subfoveal choroidal thickness(P<0.001).CONCLUSION:CLD patients exhibit structural alterations in both the anterior and posterior segments of the eye,including notable changes in retinal and choroidal vasculature.However,there is limited evidence concerning the influence of leptin therapy on the eye.
摘要BACKGROUND Immunoglobulin A(IgA)vasculitis,formerly known as Henoch-Schönlein purpura,is a small vessel vasculitis predominantly affecting children.It commonly presents with a triad of purpuric rash,arthralgia,and abdominal pain.However,dermatologic manifestations of IgA vasculitis in black-skinned individuals are poorly documented in literature.CASE SUMMARY This case report describes an 11-year-old black girl with acute onset of rash,joint pain,and abdominal pain,subsequently diagnosed with IgA vasculitis.CONCLUSION The case highlights the importance of early recognition and supportive management in ensuring a favorable outcome,particularly in dark-skinned populations.
摘要To quantify physicians'risk and time preferences and explore the association between the preferences and their willingness to detect and disclose secondary findings(SFs)derived from genome-scale sequencing.We designed a webbased survey incorporating a multiple price list(MPL)as the instrument for risk and time preference measurement.The estimation was under the expected utility theory(EUT)and rank dependent utility(RDU)frameworks,respectively.The isoelastic and power function utility models were applied.We received responses from 87 physicians,among whom 46 completed the questionnaire(a completion rate of 52.9%).We observed positive risk-aversion coefficients under EUT(0.33,95%CI 0.15-0.51)and RDU(0.51,95%CI 0.32-0.71),suggesting that physicians were generally risk-averse.Respondents were likely to underestimate probabilities of low to moderate levels,and slightly overestimate high-level probabilities.Physicians supporting the detection and disclosure of SFs had a larger risk-aversion coefficient and a smaller discounting parameter than the non-supporters,suggesting that they were more risk-averse and discounted future utility less.Assuming heterogeneous risk perception,we found respondents underestimated low/moderate risk and slightly overestimated high risk.This study indicates that physicians who are risk-averse and discount future utility slightly are willing to detect and return SFs.The findings contribute to the debate surrounding SF disclosure and generate implications for shared decision-making in clinical genome-scale sequencing.
摘要To describe and analyze the current status of benefit-finding research in patients with chronic diseases and to provide a reference for clinical practice and future research in this field.Using Arksey and O’Malley’s scoping review methodology as a framework,we searched PubMed,Web of Science,Science Direct,and CINAHL(4 English databases);and China National Knowledge Infrastructure,the VIP Database for Chinese Technical Periodicals,the Wan Fang Database and China Biomedical Database(4 Chinese databases)for literature on benefit finding in patients with chronic diseases,with a search time frame of construction to April 20,2024,and the literature was screened,extracted,and summarized.A total of 44 papers were included,comprising 18 in Chinese and 26 in English.Among them,a total of 19 assessment tools were used,and the influential factors investigated were categorized into socio-demographic characteristics,disease-related characteristics,psychological and behavioral characteristics,coping styles,and social support.Benefit finding is found to be a positive psychological experience and important for patients with chronic diseases,and the influencing factors are complex and diverse,with a wide range of assessment tools.However,domestic tools lack autonomy and specificity.Clinical caregivers and staff should develop relevant assessment tools and formulate a personalized research plan based on the characteristics of patients with chronic diseases in China to promote the adoption of healthy lifestyles by patients with chronic diseases,improve their self-management ability,and provide a practical basis for improving the quality of life of patients with chronic diseases.
摘要Track finding is a complex optimization problem,originally introduced in particle physics for the reconstruction of the trajectories of particles.A track is typically composed of several consecutive segments,which together form a smooth curve without any bifurcations.In this paper,we investigate various modeling approaches to assess their effectiveness and impact when applied to track finding,using both quantum and classical methods.We present implementations of three classical models using CPLEX,two quantum models on actual D-Wave quantum computers,and one quantummodel on a D-Wave simulator.The results show that,while CPLEX provides better results than D-Wave on small instances,D-Wave is able to propose solutions in shorter computation times for large instances,although the gap with the optimal solution tends to increase.To the best of our knowledge,this is the first numerical study comparing a non-quantum approach based on classical algorithms(Simplex and Branch and Bound)used in commercial software with a quantum approach offered by D-Wave.The results do not show the quantum supremacy typically expected,but they do demonstrate that quantum solutions can be competitive with classical approaches,and even more efficient than some classical modeling and solving methods.
基金supported by the National Natural Science Foundation of China(No.82373415)Zhejiang Provincial Clinical Research Center for Cancer(No.2022E50008,2024ZY01056)Noncommunicable Chronic Diseases-National Science and Technology Major Project(No.2026ZD0552900)。
摘要Colorectal cancer ranks third in incidence worldwide but second in mortality(1).In China,colorectal cancer is the second most common cancer and the most prevalent gastrointestinal malignancy,with both incidence and mortality continuing to rise(2).In 2017,the Chinese Society of Clinical Oncology(CSCO)issued its guidelines for colorectal cancer.These guidelines are updated annually to incorporate the latest clinical research findings,therapeutic agents,and expert opinions(3-8).This article describes the updates made in the 2026 version compared with the 2025 version.