The generation of exawatt-class lasers,as well as high focal intensities,is an important goal in ultra-intense laser physics,and grating compressors are the key devices for achieving this goal.Since large-size diffrac...The generation of exawatt-class lasers,as well as high focal intensities,is an important goal in ultra-intense laser physics,and grating compressors are the key devices for achieving this goal.Since large-size diffraction gratings are not perfectly plane,any grating compressor inevitably introduces spatiotemporal coupling phase distortions,which reduce the focal intensity of an ultra-intense laser.In this paper,we show that the dependence of the focal intensity on the root mean square(RMS)grating surface roughness is Gaussian and that for RMS roughness below 10 nm,the focal intensity decrease is negligible,giving an RMS requirement of gratings for ultra-intense lasers.In a two-grating compressor,the impact of the large-scale part of the grating surface profiles may be negligible,because it can be completely eliminated by use of two adaptive mirrors.However,in a four-grating compressor,such elimination is almost impossible.On the basis of a complete analytical model and an improved numerical code,we study the grating compressors of two sub-exawatt laser projects(XCELS and SEL-100PW),and the results show that a two-grating compressor is the best choice for exawatt-class ultra-intense lasers such as XCELS,SEL-100PW,and OPAL.This work also provides a basis for compressor grating fabrication as part of the further development of ultra-intense lasers.展开更多
Dear Editor,Herein,we report multimodal imaging findings in three cases of focal scleral nodule(FSN).The term“unifocal helioid choroiditis”was initially proposed by Hong[1]in 1997 to describe idiopathic solitary cho...Dear Editor,Herein,we report multimodal imaging findings in three cases of focal scleral nodule(FSN).The term“unifocal helioid choroiditis”was initially proposed by Hong[1]in 1997 to describe idiopathic solitary choroidal lesions in 6 cases.In 2002,Shields et al[2]reported 60 similar cases,coining the term“solitary idiopathic choroiditis”.With the advent of enhanced depth imaging optical coherence tomography(EDI-OCT),these lesions were shown to arise in the sclera rather than the choroid.A 2020 multicenter study proposed renaming solitary idiopathic choroiditis as FSN based on multimodal imaging observations including EDI-OCT in 63 cases[3].展开更多
High-performance Si photodetectors featuring an ultrawide spectral range can be realized through femtosecond(fs)-laser modification,enabling their broad application in focal plane arrays(FPAs)for artificial intelligen...High-performance Si photodetectors featuring an ultrawide spectral range can be realized through femtosecond(fs)-laser modification,enabling their broad application in focal plane arrays(FPAs)for artificial intelligence and complex operational scenarios.However,laser-induced surface inhomogeneity and elevated dark currents reduce the signal-to-noise ratio of FPAs in image detector arrays.To address these challenges,a pulse-shaping technique is employed here to precisely control light-matter interactions during laser modification.This approach not only improves the uniformity of surface microstructures but also significantly suppresses dark currents.The optimized device exhibits high responsivity across the visible to near-infrared spectrum,with a peak responsivity of 164.17 A·W-1 at−2.5 V.Notably,the photodetector demonstrates exceptional weak-light detection capacity at room temperature owing to its record-high specific detectivity of 1.71×1014 Jones,surpassing that of all previously reported Si-based photodetectors.These results highlight substantial advancements in the application of fs-laser-modified Si photodetectors,underscoring their potential in fields such as autonomous driving,weak-light detection,and medical monitoring.展开更多
This is an erratum to the published paper entitled“Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis...This is an erratum to the published paper entitled“Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis”.Upon reexamining our original data,we have identified an error in the assembly of Figure 1F,where the glyceraldehyde-3-phosphate dehydrogenase loading control image was incorrectly placed due to a clerical oversight during figure preparation.This does not reflect any issue with the underlying experimental data.展开更多
Dear Editor,We read with interest the article by Liu et al[1]on a 28-year-old woman with mitochondrial encephalopathy,lactic acidosis syndrome,and strokelike syndrome(MELAS)due to the m.3243A>G variant confirmed in...Dear Editor,We read with interest the article by Liu et al[1]on a 28-year-old woman with mitochondrial encephalopathy,lactic acidosis syndrome,and strokelike syndrome(MELAS)due to the m.3243A>G variant confirmed in blood lymphocytes.The MT-TL1 variant manifested clinically with focal segmental glomerulosclerosis(FSGS),which required hemodialysis,heart failure,arterial hypertension,and hearing impairment[1].Although the patient reported no visual symptoms,ophthalmological examination revealed changes in the perimacular and peripapillary retinal pigment epithelium(RPE)[1].The study is noteworthy,but some points require discussion.展开更多
This study proposes a method for determining earthquake focal depths by combining the sPn phase with the waveform cross-correlation technique,based on waveform data recorded by the Fujian Seismic Network from the 2024...This study proposes a method for determining earthquake focal depths by combining the sPn phase with the waveform cross-correlation technique,based on waveform data recorded by the Fujian Seismic Network from the 2024 M 7.3 Hualien offshore earthquake and the 2025 M 6.2 Tainan earthquake.The Pn phase onset was precisely aligned using waveform cross-correlation,and the arrival time difference(Δt)between the sPn and Pn phases was extracted via a sliding time-window correlation method.The focal depths were derived using a layered velocity model for the Taiwan region.Results show that the calculated focal depth for the Hualien earthquake is 23.1 km(Δt=6.9 s),with a relative error of 2.7%compared to the official result(22.5 km)from the Central Weather Administration of Taiwan.For the Tainan earthquake,the depth is 17.9 km(Δt=6.1 s),with a relative error of 13.3%.In this study,we show that a cross-correlation threshold of 0.8 and a bandpass filtering of 0.1–0.3 Hz are efficient to suppress noise and significantly improve depth accuracy for shallow earthquakes with depth<30 km.Compared to traditional travel-time location methods,this approach exhibits superior noise resistance and computational efficiency.Future work will focus on optimizing 3D velocity structures,integrating multiple phases,and applying deep learning techniques such as convolutional neural networks,aiming to improve the results in a more reliable and automatic way,and to provide efficient support on earthquake emergency response.展开更多
On March 28, 2025, an MS7.9 earthquake occurred in the Himalayan-Myanmar Arc at the junction of the Indian Plate and the Eurasian Plate. Utilizing broadband waveform data provided by the Global Seismographic Networ...On March 28, 2025, an MS7.9 earthquake occurred in the Himalayan-Myanmar Arc at the junction of the Indian Plate and the Eurasian Plate. Utilizing broadband waveform data provided by the Global Seismographic Network, this study adopted the Wphase method and the P-wave first-motion polarity method to invert the centroid-moment-tensor and fault plane solutions of this earthquake. Additionally, the far-field point source model, global attenuation model, and energy flux density method were used to determine the radiated energy of this earthquake. The energy-moment ratio, apparent stress, stress drop, and radiated energy enhancement factor were also calculated based on the measured seismic moment. The main findings are as follows:(1) this event was a strike-slip earthquake with steeply dipping faults. The focal mechanism solution yielded two nodal planes: Plane Ⅰ(strike 358°, dip 70°, rake-175°) and Plane Ⅱ(strike 266°, dip 85°, rake-20°). The seismic moment of 4.94 × 1020 N·m corresponds to a moment magnitude of 7.7. The centroid was located at 21.21°N and 95.92°E and a depth of 35.0 km. The centroid time was 35 s.(2) The radiated seismic energy was 2.6 × 1016 J, which was converted to an energy magnitude of 8.0,higher than the moment magnitude.(3) The energy-moment ratio was 5.3 × 10-5, apparent stress was 1.58 MPa, stress drop was6.79 MPa, and radiated energy enhancement factor describing the complexity of fault rupture was calculated as 113.(4) In summary, the Myanmar earthquake is a strike-slip earthquake, characterized by steeply dipping faults and highly efficient energy release. Compared with earthquakes of the same magnitude, such earthquakes have a greater destructive power on local buildings and infrastructure, increasing the likelihood of severe disasters.展开更多
The hydraulic fracturing of horizontal wells is a key stimulation technology for unconventional tight oil/gas reservoirs.Good knowledge of the near-well stress eld of a horizontal well can be helpful for the hydraulic...The hydraulic fracturing of horizontal wells is a key stimulation technology for unconventional tight oil/gas reservoirs.Good knowledge of the near-well stress eld of a horizontal well can be helpful for the hydraulic fracture design optimization of new wells and refrac design optimization of fractured wells.Azimuth and dip data derived from either focal mechanisms of hydraulic fracturing-induced microseismic events or fracture attributes of hydraulic fracture networks can be used for new-well stress eld inversion.In this work,we present a novel stress inversion method integrating azimuth,dip,and rake data from the focal mechanisms of hydraulically induced microseismic events and fracture attributes of hydraulic fracture networks.For those stages having sufcient reliable microseismic focal mechanisms,strike,dip,and rake data derived from microseismic focal mechanisms are taken as input data for stress inversion.Meanwhile,for those stages that have no microseismic events or insufficient reliable microseismic focal mechanisms,azimuth and dip data derived from fracture attributes of prebuilt hydraulic fracture network are used for stress inversion,along with azimuth,dip,and rake data derived from other stages with sufcient reliable microseismic focal mechanisms.Thus,the near-well stress eld of each stage can be inverted,regardless of whether or not it has hydraulically induced microseismic events.The new method has been applied in the eld surface microseismic dataset during hydraulic fracture stimulation.The results reveal that the inverted near-well stress elds are consistent with the stress orientation derived from shear-wave splitting analysis for sonic logs.This nding demonstrates that the stress inversion method based on strike,dip,and rake data derived from microseismic focal mechanisms and fracture networks can correctly obtain the azimuths of maximum and minimum horizontal stress.展开更多
Near-infrared image sensors are widely used in fields such as material identification,machine vision,and autonomous driving.Lead sulfide colloidal quantum dot-based infrared photodiodes can be integrated with sil⁃icon...Near-infrared image sensors are widely used in fields such as material identification,machine vision,and autonomous driving.Lead sulfide colloidal quantum dot-based infrared photodiodes can be integrated with sil⁃icon-based readout circuits in a single step.Based on this,we propose a photodiode based on an n-i-p structure,which removes the buffer layer and further simplifies the manufacturing process of quantum dot image sensors,thus reducing manufacturing costs.Additionally,for the noise complexity in quantum dot image sensors when capturing images,traditional denoising and non-uniformity methods often do not achieve optimal denoising re⁃sults.For the noise and stripe-type non-uniformity commonly encountered in infrared quantum dot detector imag⁃es,a network architecture has been developed that incorporates multiple key modules.This network combines channel attention and spatial attention mechanisms,dynamically adjusting the importance of feature maps to en⁃hance the ability to distinguish between noise and details.Meanwhile,the residual dense feature fusion module further improves the network's ability to process complex image structures through hierarchical feature extraction and fusion.Furthermore,the pyramid pooling module effectively captures information at different scales,improv⁃ing the network's multi-scale feature representation ability.Through the collaborative effect of these modules,the network can better handle various mixed noise and image non-uniformity issues.Experimental results show that it outperforms the traditional U-Net network in denoising and image correction tasks.展开更多
BACKGROUND The role of FNDC5/irisin in regulating sensitivity to pancreatic ductal adenocarcinoma(PAAD)chemotherapy remains unclear.AIM To explore the role of FNDC5/irisin in regulating sensitivity to PAAD chemotherap...BACKGROUND The role of FNDC5/irisin in regulating sensitivity to pancreatic ductal adenocarcinoma(PAAD)chemotherapy remains unclear.AIM To explore the role of FNDC5/irisin in regulating sensitivity to PAAD chemotherapy.METHODS The prognostic significance of FNDC5 was analyzed using bioinformatics.PAAD cells with FNDC5 overexpression,treated with quercetin,and control cells were compared in vitro.Cell proliferation was measured by real-time cellular analysis and colony formation assays,while apoptosis and anoikis were assessed flow cytometry.Protein expression was determined by western blotting,gene expression was determined by real-time quantitative polymerase chain reaction,and mitochondrial membrane potential was determined using the JC-1 method.FNDC5 suppressed the focal adhesion kinase(FAK)/phosphatidylinositol 3-kinase/protein kinase B pathway,leading to mitochondrial-dependent apoptosis and anoikis through modulation of apoptosis-related proteins.CONCLUSION Our findings suggest that the FNDC5/FAK axis as a novel regulator of anoikis sensitivity in PAAD.Targeting this axis may represent a promising strategy to enhance the efficacy of quercetin and other natural compounds,offering a potential therapeutic approach to overcome chemoresistance in this aggressive malignancy.展开更多
BACKGROUND Focal segmental glomerulosclerosis(FSGS)represents a major cause of nephrotic syndrome,with glucocorticoids constituting first-line therapy.When patients develop steroid dependence or resistance,calcineurin...BACKGROUND Focal segmental glomerulosclerosis(FSGS)represents a major cause of nephrotic syndrome,with glucocorticoids constituting first-line therapy.When patients develop steroid dependence or resistance,calcineurin inhibitors(CNIs)serve as effective alternatives.However,CNI dependence or resistance may emerge,and prolonged use of either steroid or CNI therapy carries substantial toxicity risks.These limitations create an unmet need for safer treatments capable of maintaining durable remission.CASE SUMMARY The patient initially presented with acute anasarca,nephrotic-range proteinuria(5.6 g/24 hours),hypoalbuminemia(2.1 g/dL),and preserved renal function.She experienced repeated relapses after corticosteroid and cyclosporine tapering,ultimately exhibiting a steroid-and CNI-dependent disease course.Rituximab was administered as two 1 g infusions 14 days apart,resulting in complete remission sustained for five years.CONCLUSION This case contributes to the growing evidence supporting rituximab’s therapeutic potential in adult FSGS,while highlighting the need for randomized controlled trials to establish its efficacy and optimal use in this challenging patient population.展开更多
Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challe...Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challenges.In this work,we demonstrate for the firs time that the coherent radiation farfiel patterns from laser–foil interactions can serve as an in situ,real-time,and easy-to-implement diagnostic for an ultraintense laser focus.The laser-driven electron sheets,curved by the spatially varying laser fiel and leaving the targets at nearly the speed of light,produce doughnut-shaped patterns depending on the shapes of the focal spot and the absolute laser intensities.Assisted by particle-in-cell simulations,we can achieve measurements of the intensity and the focal spot,and provide immediate feedback to optimize the focal spots for extremely high intensity.展开更多
Achieving high-level integration of composite micro-nano structures with different structural characteristics through a minimalist and universal process has long been the goal pursued by advanced manufacturing researc...Achieving high-level integration of composite micro-nano structures with different structural characteristics through a minimalist and universal process has long been the goal pursued by advanced manufacturing research but is rarely explored due to the absence of instructive mechanisms.Here,we revealed a controllable ultrafast laser-induced focal volume light field and experimentally succeeded in highly efficient one-step composite structuring in multiple transparent solids.A pair of spatially coupled twin periodic structures reflecting light distribution in the focal volume are simultaneously created and independently tuned by engineering ultrafast laser-matter interaction.We demonstrated that the generated composite micro-nano structures are applicable to multi-dimensional information integration,nonlinear diffractive elements,and multi-functional optical modulation.This work presents the experimental verification of highly universal all-optical fabrication of composite micro-nano structures with independent controllability in multiple degrees of freedom,expands the current cognition of ultrafast laser-based material modification in transparent solids,and establishes a new scientific aspect of strong-field optics,namely,focal volume optics for composite structuring transparent solids.展开更多
On December 18,2023,an Ms6.2 earthquake jolted Jishishan County in the Linxia Hui Autonomous Prefecture in Northwest China's Gansu Province,causing substantial casualties and building collapses.The earthquake o...On December 18,2023,an Ms6.2 earthquake jolted Jishishan County in the Linxia Hui Autonomous Prefecture in Northwest China's Gansu Province,causing substantial casualties and building collapses.The earthquake occurred in the Qilian Block on the northeastern border of the Qinghai-Tibet Plateau,where faults are highly active and the geological structure is complex.In this study,we utilized methods such as relocation,focal mechanism solutions,and earthquake rupture processes to describe seismogenic faults.The results indicated that the majority of aftershocks occurred at a depth of 12 km.The centroid depth of the main shock and the depth of the maximum rupture point during the rupture process were also 12 km.Various geophysical methods exhibited a high degree of consistency in depth exploration.Aftershocks were distributed mainly to the west and north of the main shock and extended in the NNW direction,primarily through unilateral rupture.The main shock was a reverse thrust event with a small dextral strike-slip component.In this study,more regional data,such as previous GPS observations,field geological observations,and the distributions of the primary stress states in the region,were also incorporated.We inferred that the main shock was triggered by the main fault at the northern margin of the Lajishan Fault and that the movement of the main fault also activated some secondary faults.The compressive forces on both sides of the Lajishan Fault Zone led to the uplift of mountain areas,accompanied by some landslides,leading to this catastrophic earthquake event.In this article,the activity relationships among the 2022 Ms6.9 Menyuan earthquake,the 2019 Ms5.7 Xiahe earthquake,and the Jishishan earthquake under the action of regional stress are also discussed.This study provides additional evidence and new ideas for exploring the seismogenic process of the Lajishan Fault Zone and has implications for future in-depth research on underground activity in this region.展开更多
High-power laser systems have opened new frontiers in scientifi research and have revolutionized various scientifi fields offering unprecedented capabilities for understanding fundamental physics and allowing unique a...High-power laser systems have opened new frontiers in scientifi research and have revolutionized various scientifi fields offering unprecedented capabilities for understanding fundamental physics and allowing unique applications.This paper details the successful commissioning of the 1 PW experimental area at the Extreme Light Infrastructure–Nuclear Physics(ELI-NP)facility in Romania,using both of the available laser arms.The experimental setup featured a short focal parabolic mirror to accelerate protons through the target normal sheath acceleration mechanism.Detailed experiments were conducted using various metallic and diamond-like carbon targets to investigate the dependence of the proton acceleration on different laser parameters.Furthermore,the paper discusses the critical role of the laser temporal profil in optimizing proton acceleration,supported by hydrodynamic simulations that are correlated with experimental outcomes.The finding underscore the potential of the ELI-NP facility to advance research in laser–plasma physics and contribute significantl to high-energy physics applications.The results of this commissioning establish a strong foundation for experiments by future users.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.62527901,12388102,and 61925507)the Ministry of Science and Higher Education of the Russian Federation(Grant No.FFUF-2025-0011)+2 种基金the National Key R&D Program of China(Grant Nos.2022YFA1604401 and 2022YFE0204800)the Shanghai Science and Technology Committee Program(Grant Nos.22DZ1100300,22560780100,and 23560750200)the Chinese Academy of Sciences President’s International Fellowship Initiative(Grant No.2024PVA0035)。
摘要The generation of exawatt-class lasers,as well as high focal intensities,is an important goal in ultra-intense laser physics,and grating compressors are the key devices for achieving this goal.Since large-size diffraction gratings are not perfectly plane,any grating compressor inevitably introduces spatiotemporal coupling phase distortions,which reduce the focal intensity of an ultra-intense laser.In this paper,we show that the dependence of the focal intensity on the root mean square(RMS)grating surface roughness is Gaussian and that for RMS roughness below 10 nm,the focal intensity decrease is negligible,giving an RMS requirement of gratings for ultra-intense lasers.In a two-grating compressor,the impact of the large-scale part of the grating surface profiles may be negligible,because it can be completely eliminated by use of two adaptive mirrors.However,in a four-grating compressor,such elimination is almost impossible.On the basis of a complete analytical model and an improved numerical code,we study the grating compressors of two sub-exawatt laser projects(XCELS and SEL-100PW),and the results show that a two-grating compressor is the best choice for exawatt-class ultra-intense lasers such as XCELS,SEL-100PW,and OPAL.This work also provides a basis for compressor grating fabrication as part of the further development of ultra-intense lasers.
摘要Dear Editor,Herein,we report multimodal imaging findings in three cases of focal scleral nodule(FSN).The term“unifocal helioid choroiditis”was initially proposed by Hong[1]in 1997 to describe idiopathic solitary choroidal lesions in 6 cases.In 2002,Shields et al[2]reported 60 similar cases,coining the term“solitary idiopathic choroiditis”.With the advent of enhanced depth imaging optical coherence tomography(EDI-OCT),these lesions were shown to arise in the sclera rather than the choroid.A 2020 multicenter study proposed renaming solitary idiopathic choroiditis as FSN based on multimodal imaging observations including EDI-OCT in 63 cases[3].
基金supported by the National Key Research and Development Program of China(2024YFA1409500)the National Natural Science Foundation of China(12504364 and 12474344)the 111 project(B23045).
摘要High-performance Si photodetectors featuring an ultrawide spectral range can be realized through femtosecond(fs)-laser modification,enabling their broad application in focal plane arrays(FPAs)for artificial intelligence and complex operational scenarios.However,laser-induced surface inhomogeneity and elevated dark currents reduce the signal-to-noise ratio of FPAs in image detector arrays.To address these challenges,a pulse-shaping technique is employed here to precisely control light-matter interactions during laser modification.This approach not only improves the uniformity of surface microstructures but also significantly suppresses dark currents.The optimized device exhibits high responsivity across the visible to near-infrared spectrum,with a peak responsivity of 164.17 A·W-1 at−2.5 V.Notably,the photodetector demonstrates exceptional weak-light detection capacity at room temperature owing to its record-high specific detectivity of 1.71×1014 Jones,surpassing that of all previously reported Si-based photodetectors.These results highlight substantial advancements in the application of fs-laser-modified Si photodetectors,underscoring their potential in fields such as autonomous driving,weak-light detection,and medical monitoring.
基金Supported by the National Natural Science Foundation of China,No.82205002 and No.82104662the Science and Technology Project of Sichuan Province,No.2022YFS0621+1 种基金Luzhou-Southwest Medical University Science and Technology Strategic Cooperation Project,No.2021 LZXNYD-P04the Southwest Medical University of Affiliated Traditional Medicine Hospital Project,No.2022-CXTD-03。
摘要This is an erratum to the published paper entitled“Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis”.Upon reexamining our original data,we have identified an error in the assembly of Figure 1F,where the glyceraldehyde-3-phosphate dehydrogenase loading control image was incorrectly placed due to a clerical oversight during figure preparation.This does not reflect any issue with the underlying experimental data.
摘要Dear Editor,We read with interest the article by Liu et al[1]on a 28-year-old woman with mitochondrial encephalopathy,lactic acidosis syndrome,and strokelike syndrome(MELAS)due to the m.3243A>G variant confirmed in blood lymphocytes.The MT-TL1 variant manifested clinically with focal segmental glomerulosclerosis(FSGS),which required hemodialysis,heart failure,arterial hypertension,and hearing impairment[1].Although the patient reported no visual symptoms,ophthalmological examination revealed changes in the perimacular and peripapillary retinal pigment epithelium(RPE)[1].The study is noteworthy,but some points require discussion.
基金funded by the National Key Research and Development Program of China(Grant No.2024YFC3012804)。
摘要This study proposes a method for determining earthquake focal depths by combining the sPn phase with the waveform cross-correlation technique,based on waveform data recorded by the Fujian Seismic Network from the 2024 M 7.3 Hualien offshore earthquake and the 2025 M 6.2 Tainan earthquake.The Pn phase onset was precisely aligned using waveform cross-correlation,and the arrival time difference(Δt)between the sPn and Pn phases was extracted via a sliding time-window correlation method.The focal depths were derived using a layered velocity model for the Taiwan region.Results show that the calculated focal depth for the Hualien earthquake is 23.1 km(Δt=6.9 s),with a relative error of 2.7%compared to the official result(22.5 km)from the Central Weather Administration of Taiwan.For the Tainan earthquake,the depth is 17.9 km(Δt=6.1 s),with a relative error of 13.3%.In this study,we show that a cross-correlation threshold of 0.8 and a bandpass filtering of 0.1–0.3 Hz are efficient to suppress noise and significantly improve depth accuracy for shallow earthquakes with depth<30 km.Compared to traditional travel-time location methods,this approach exhibits superior noise resistance and computational efficiency.Future work will focus on optimizing 3D velocity structures,integrating multiple phases,and applying deep learning techniques such as convolutional neural networks,aiming to improve the results in a more reliable and automatic way,and to provide efficient support on earthquake emergency response.
摘要On March 28, 2025, an MS7.9 earthquake occurred in the Himalayan-Myanmar Arc at the junction of the Indian Plate and the Eurasian Plate. Utilizing broadband waveform data provided by the Global Seismographic Network, this study adopted the Wphase method and the P-wave first-motion polarity method to invert the centroid-moment-tensor and fault plane solutions of this earthquake. Additionally, the far-field point source model, global attenuation model, and energy flux density method were used to determine the radiated energy of this earthquake. The energy-moment ratio, apparent stress, stress drop, and radiated energy enhancement factor were also calculated based on the measured seismic moment. The main findings are as follows:(1) this event was a strike-slip earthquake with steeply dipping faults. The focal mechanism solution yielded two nodal planes: Plane Ⅰ(strike 358°, dip 70°, rake-175°) and Plane Ⅱ(strike 266°, dip 85°, rake-20°). The seismic moment of 4.94 × 1020 N·m corresponds to a moment magnitude of 7.7. The centroid was located at 21.21°N and 95.92°E and a depth of 35.0 km. The centroid time was 35 s.(2) The radiated seismic energy was 2.6 × 1016 J, which was converted to an energy magnitude of 8.0,higher than the moment magnitude.(3) The energy-moment ratio was 5.3 × 10-5, apparent stress was 1.58 MPa, stress drop was6.79 MPa, and radiated energy enhancement factor describing the complexity of fault rupture was calculated as 113.(4) In summary, the Myanmar earthquake is a strike-slip earthquake, characterized by steeply dipping faults and highly efficient energy release. Compared with earthquakes of the same magnitude, such earthquakes have a greater destructive power on local buildings and infrastructure, increasing the likelihood of severe disasters.
基金supported by the Fundamental Research Funds for the Central Universities(No.2022JCCXMT01).
摘要The hydraulic fracturing of horizontal wells is a key stimulation technology for unconventional tight oil/gas reservoirs.Good knowledge of the near-well stress eld of a horizontal well can be helpful for the hydraulic fracture design optimization of new wells and refrac design optimization of fractured wells.Azimuth and dip data derived from either focal mechanisms of hydraulic fracturing-induced microseismic events or fracture attributes of hydraulic fracture networks can be used for new-well stress eld inversion.In this work,we present a novel stress inversion method integrating azimuth,dip,and rake data from the focal mechanisms of hydraulically induced microseismic events and fracture attributes of hydraulic fracture networks.For those stages having sufcient reliable microseismic focal mechanisms,strike,dip,and rake data derived from microseismic focal mechanisms are taken as input data for stress inversion.Meanwhile,for those stages that have no microseismic events or insufficient reliable microseismic focal mechanisms,azimuth and dip data derived from fracture attributes of prebuilt hydraulic fracture network are used for stress inversion,along with azimuth,dip,and rake data derived from other stages with sufcient reliable microseismic focal mechanisms.Thus,the near-well stress eld of each stage can be inverted,regardless of whether or not it has hydraulically induced microseismic events.The new method has been applied in the eld surface microseismic dataset during hydraulic fracture stimulation.The results reveal that the inverted near-well stress elds are consistent with the stress orientation derived from shear-wave splitting analysis for sonic logs.This nding demonstrates that the stress inversion method based on strike,dip,and rake data derived from microseismic focal mechanisms and fracture networks can correctly obtain the azimuths of maximum and minimum horizontal stress.
基金Supported by the National key research and development program in the 14th five year plan 2021YFA1200700)the National Natural Science Foundation of China(62535018,62431025,62561160113)the Natural Science Foundation of Shanghai(23ZR1473400).
摘要Near-infrared image sensors are widely used in fields such as material identification,machine vision,and autonomous driving.Lead sulfide colloidal quantum dot-based infrared photodiodes can be integrated with sil⁃icon-based readout circuits in a single step.Based on this,we propose a photodiode based on an n-i-p structure,which removes the buffer layer and further simplifies the manufacturing process of quantum dot image sensors,thus reducing manufacturing costs.Additionally,for the noise complexity in quantum dot image sensors when capturing images,traditional denoising and non-uniformity methods often do not achieve optimal denoising re⁃sults.For the noise and stripe-type non-uniformity commonly encountered in infrared quantum dot detector imag⁃es,a network architecture has been developed that incorporates multiple key modules.This network combines channel attention and spatial attention mechanisms,dynamically adjusting the importance of feature maps to en⁃hance the ability to distinguish between noise and details.Meanwhile,the residual dense feature fusion module further improves the network's ability to process complex image structures through hierarchical feature extraction and fusion.Furthermore,the pyramid pooling module effectively captures information at different scales,improv⁃ing the network's multi-scale feature representation ability.Through the collaborative effect of these modules,the network can better handle various mixed noise and image non-uniformity issues.Experimental results show that it outperforms the traditional U-Net network in denoising and image correction tasks.
基金Supported by the National Natural Science Foundation of China, No. 82074204.
摘要BACKGROUND The role of FNDC5/irisin in regulating sensitivity to pancreatic ductal adenocarcinoma(PAAD)chemotherapy remains unclear.AIM To explore the role of FNDC5/irisin in regulating sensitivity to PAAD chemotherapy.METHODS The prognostic significance of FNDC5 was analyzed using bioinformatics.PAAD cells with FNDC5 overexpression,treated with quercetin,and control cells were compared in vitro.Cell proliferation was measured by real-time cellular analysis and colony formation assays,while apoptosis and anoikis were assessed flow cytometry.Protein expression was determined by western blotting,gene expression was determined by real-time quantitative polymerase chain reaction,and mitochondrial membrane potential was determined using the JC-1 method.FNDC5 suppressed the focal adhesion kinase(FAK)/phosphatidylinositol 3-kinase/protein kinase B pathway,leading to mitochondrial-dependent apoptosis and anoikis through modulation of apoptosis-related proteins.CONCLUSION Our findings suggest that the FNDC5/FAK axis as a novel regulator of anoikis sensitivity in PAAD.Targeting this axis may represent a promising strategy to enhance the efficacy of quercetin and other natural compounds,offering a potential therapeutic approach to overcome chemoresistance in this aggressive malignancy.
摘要BACKGROUND Focal segmental glomerulosclerosis(FSGS)represents a major cause of nephrotic syndrome,with glucocorticoids constituting first-line therapy.When patients develop steroid dependence or resistance,calcineurin inhibitors(CNIs)serve as effective alternatives.However,CNI dependence or resistance may emerge,and prolonged use of either steroid or CNI therapy carries substantial toxicity risks.These limitations create an unmet need for safer treatments capable of maintaining durable remission.CASE SUMMARY The patient initially presented with acute anasarca,nephrotic-range proteinuria(5.6 g/24 hours),hypoalbuminemia(2.1 g/dL),and preserved renal function.She experienced repeated relapses after corticosteroid and cyclosporine tapering,ultimately exhibiting a steroid-and CNI-dependent disease course.Rituximab was administered as two 1 g infusions 14 days apart,resulting in complete remission sustained for five years.CONCLUSION This case contributes to the growing evidence supporting rituximab’s therapeutic potential in adult FSGS,while highlighting the need for randomized controlled trials to establish its efficacy and optimal use in this challenging patient population.
基金supported by the Guangdong High Level Innovation Research Institute(Grant No.2021B0909050006)the National Grand Instrument Project(Grant No.2019YFF01014402)+1 种基金the National Natural Science Foundation of China(Grant No.12205008)support from the National Science Fund for Distinguished Young Scholars(Grant No.12225501)。
摘要Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challenges.In this work,we demonstrate for the firs time that the coherent radiation farfiel patterns from laser–foil interactions can serve as an in situ,real-time,and easy-to-implement diagnostic for an ultraintense laser focus.The laser-driven electron sheets,curved by the spatially varying laser fiel and leaving the targets at nearly the speed of light,produce doughnut-shaped patterns depending on the shapes of the focal spot and the absolute laser intensities.Assisted by particle-in-cell simulations,we can achieve measurements of the intensity and the focal spot,and provide immediate feedback to optimize the focal spots for extremely high intensity.
基金financially supported by the National Key Research and Development Program of China(No.2021YFB2802001)the National Natural Science Foundation of China(Grant Nos.12304349,U20A20211,62275233)the Postdoctoral Fellowship Program of CPSF(GZB20230628,GZC20241465)。
摘要Achieving high-level integration of composite micro-nano structures with different structural characteristics through a minimalist and universal process has long been the goal pursued by advanced manufacturing research but is rarely explored due to the absence of instructive mechanisms.Here,we revealed a controllable ultrafast laser-induced focal volume light field and experimentally succeeded in highly efficient one-step composite structuring in multiple transparent solids.A pair of spatially coupled twin periodic structures reflecting light distribution in the focal volume are simultaneously created and independently tuned by engineering ultrafast laser-matter interaction.We demonstrated that the generated composite micro-nano structures are applicable to multi-dimensional information integration,nonlinear diffractive elements,and multi-functional optical modulation.This work presents the experimental verification of highly universal all-optical fabrication of composite micro-nano structures with independent controllability in multiple degrees of freedom,expands the current cognition of ultrafast laser-based material modification in transparent solids,and establishes a new scientific aspect of strong-field optics,namely,focal volume optics for composite structuring transparent solids.
基金funded by the National Natural Science Foundation of China(Grant No.42304072)。
摘要On December 18,2023,an Ms6.2 earthquake jolted Jishishan County in the Linxia Hui Autonomous Prefecture in Northwest China's Gansu Province,causing substantial casualties and building collapses.The earthquake occurred in the Qilian Block on the northeastern border of the Qinghai-Tibet Plateau,where faults are highly active and the geological structure is complex.In this study,we utilized methods such as relocation,focal mechanism solutions,and earthquake rupture processes to describe seismogenic faults.The results indicated that the majority of aftershocks occurred at a depth of 12 km.The centroid depth of the main shock and the depth of the maximum rupture point during the rupture process were also 12 km.Various geophysical methods exhibited a high degree of consistency in depth exploration.Aftershocks were distributed mainly to the west and north of the main shock and extended in the NNW direction,primarily through unilateral rupture.The main shock was a reverse thrust event with a small dextral strike-slip component.In this study,more regional data,such as previous GPS observations,field geological observations,and the distributions of the primary stress states in the region,were also incorporated.We inferred that the main shock was triggered by the main fault at the northern margin of the Lajishan Fault and that the movement of the main fault also activated some secondary faults.The compressive forces on both sides of the Lajishan Fault Zone led to the uplift of mountain areas,accompanied by some landslides,leading to this catastrophic earthquake event.In this article,the activity relationships among the 2022 Ms6.9 Menyuan earthquake,the 2019 Ms5.7 Xiahe earthquake,and the Jishishan earthquake under the action of regional stress are also discussed.This study provides additional evidence and new ideas for exploring the seismogenic process of the Lajishan Fault Zone and has implications for future in-depth research on underground activity in this region.
基金supported by the Extreme Light Infrastructure–Nuclear Physics(ELI-NP)PhaseⅡa project co-finance by the Romanian Government and the European Union through the European Regional Development Fund,by the Romanian Ministry of Education and Research CNCS-UEFISCDI(Project No.PN-ⅡIP4-IDPCCF-2016-0164)+1 种基金Nucleu Projects(Grant No.PN 23210105 and 19060105)supports ELI-NP through IOSIN funds as a Facility of National Interest。
摘要High-power laser systems have opened new frontiers in scientifi research and have revolutionized various scientifi fields offering unprecedented capabilities for understanding fundamental physics and allowing unique applications.This paper details the successful commissioning of the 1 PW experimental area at the Extreme Light Infrastructure–Nuclear Physics(ELI-NP)facility in Romania,using both of the available laser arms.The experimental setup featured a short focal parabolic mirror to accelerate protons through the target normal sheath acceleration mechanism.Detailed experiments were conducted using various metallic and diamond-like carbon targets to investigate the dependence of the proton acceleration on different laser parameters.Furthermore,the paper discusses the critical role of the laser temporal profil in optimizing proton acceleration,supported by hydrodynamic simulations that are correlated with experimental outcomes.The finding underscore the potential of the ELI-NP facility to advance research in laser–plasma physics and contribute significantl to high-energy physics applications.The results of this commissioning establish a strong foundation for experiments by future users.