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Interplay Between Biomolecular Folding and Liquid-Liquid Phase Separation 认领 引用
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作者 Qi Tian Chunhong Zhou +3 位作者 Weitong Ren Yunqiang Bian Wenfei Li Wei Wang 《Chinese Physics Letters》 SCIE EI CAS CSCD 2026年第6期147-152,I0138-I0142,共6页
Biomolecules can form condensates through liquid-liquid phase separation(LLPS)to perform biological functions.It is well established that intrinsically disordered proteins play essential roles in driving LLPS,and thei... Biomolecules can form condensates through liquid-liquid phase separation(LLPS)to perform biological functions.It is well established that intrinsically disordered proteins play essential roles in driving LLPS,and their conformations tend to adopt more extended states within the dense phase.However,for proteins with folded structures,how the folding of individual chains and phase separation mutually influence each other remains unclear.Here,using the nucleocapsid protein 7(NCp7)of human immunodeficiency virus 1(HIV-1)and its cognate RNA as a model system,we investigated the coupling between protein folding and phase separation through coarse-grained molecular dynamics simulations.We found that the folding of NCp7 into its native structure,which contains two zinc finger(ZF)motifs,increases the multivalency of protein-RNA interactions and promotes their co-condensation.In turn,phase separation further stabilizes the native structure of the protein by facilitating non-native interactions within the condensates,where biomolecule concentration and molecular crowding are high.Additionally,RNA exhibits a highly dynamic structure,which enables it to simultaneously engage in protein interactions and adopt interchain double-stranded helical conformations,thereby mediating a balance between protein-RNA attraction and RNA-RNA repulsion.The results of this work suggest that tuning the folding and stability of individual biomolecules(e.g.,through metal-ion binding)offers an effective route to modulate biomolecular condensation,highlighting a promising strategy for drug design targeting the macroscopic phase behavior of biomolecules. 展开更多
关键词 phase separation biomolecular folding protein RNA interactions human immunodeficiency virus perform biological functionsit nucleocapsid protein intrinsically disordered proteins folding individual chains
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From Hands-on Practice to Mathematical Inquiry:Task-Chain Design in Junior High School Mathematics Comprehensive and Practical Activities-A Case Study of Geometric Relationships in Paper Folding 认领 引用
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作者 LIU Chunyun 《US-China Education Review(A)》 2026年第6期451-458,共8页
Hands-on work in junior high school mathematics has instructional value when it draws students into mathematical questions rather than stopping at finished products.Taking the lesson“Geometric Relationships in Paper ... Hands-on work in junior high school mathematics has instructional value when it draws students into mathematical questions rather than stopping at finished products.Taking the lesson“Geometric Relationships in Paper Folding”as a case,this paper discusses how a sequence of folding tasks can be organized around creases.Students begin with familiar paper shapes,make and mark creases,compare the relationships they see,and then explain parallelism,symmetry,equal sides,and transfer under changed conditions.The chain is arranged as situational activation,operational generation,relationship discovery,mathematical explanation,and transfer application.The crease becomes the hinge between action and reasoning:It starts as a physical trace,is read as a geometric line,axis,bisector,or boundary relation,and finally serves as evidence in explanation.When students are required to record their folds,name relationships,and check their reasons,paper folding can remain open-ended while keeping a clear mathematical focus. 展开更多
关键词 junior high school mathematics comprehensive and practical activities paper folding task chain mathematization
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Improvement of Artificial Foldable Wing Models by Mimicking the Unfolding/Folding Mechanism of a Beetle Hind Wing 认领 引用 被引量：11
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作者 Azhar Muhammad Quoc Viet Nguyen +3 位作者 Hoon Cheol Park Do Y.Hwang Doyoung Byun Nam Seo Goo 《Journal of Bionic Engineering》 SCIE EI 2010年第2期134-141,共8页
In an attempt to realize a flapping wing micro-air vehicle with morphing wings, we report on improvements to our previousfoldable artificial hind wing.Multiple hinges, which were implemented to mimic the bending zone ... In an attempt to realize a flapping wing micro-air vehicle with morphing wings, we report on improvements to our previousfoldable artificial hind wing.Multiple hinges, which were implemented to mimic the bending zone of a beetle hind wing, weremade of small composite hinge plates and tiny aluminum rivets.The buck-tails of rivets were flared after the hinge plates wereassembled with the rivets so that the folding/unfolding motions could be completed in less time, and the straight shape of theartificial hind wing could be maintained after fabrication.Folding and unfolding actions were triggered by electrically-activatedShape Memory Alloy (SMA) wires.For wing folding, the actuation characteristics of the SMA wire actuator were modifiedthrough heat treatment.Through a series of flapping tests, we confirmed that the artificial wings did not fold back and arbitrarilyfluctuate during the flapping motion. 展开更多
关键词 hind wing unfolding folding shape memory alloy folding ratio artificial wing
Investigation of Chain Folding and Traversing during Melt Crystallization of Poly(L-lactide)Based on Selective Alkali Hydrolysis of Its Amorphous Regions 认领 引用
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作者 Yu-Fei Dong Xin-Yang Zhou +4 位作者 Zhao-Hua Ren Jia-Chen Zhang Man Xi Jia-Yao Wang Ji-Chun You 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2025年第12期2395-2402,I0015,共8页
An efficient strategy has been developed to reconstruct chain folding and traversing of poly(L-lactide)(PLLA)during melt crystallization based on the selective hydrolysis of its amorphous regions.The molecular weights... An efficient strategy has been developed to reconstruct chain folding and traversing of poly(L-lactide)(PLLA)during melt crystallization based on the selective hydrolysis of its amorphous regions.The molecular weights of the pristine PLLA(crystalline part),single stem,and single cluster were determined by gel permeation chromatography(GPC)according to their evolution during alkali hydrolysis.The maximum-folding-number(in a single cluster)and minimum-cluster-number(in one polymer chain)were obtained using these molecular weights.With the help of two numbers,the chain folding and traversing during the melt crystallization process(at 120℃)of PLLA can be described as follows.Statistically,in a single polymer chain,there are at least 2 clusters consisting of up to 6.5 stems in each of them,while the rest of the polymer chain contributes to amorphous regions.Our results provide a new strategy for the investigation and fundamental understanding of the melt crystallization of PLLA. 展开更多
关键词 Crystallization Chain folding Chain traversing PLLA Alkali hydrolysis
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Force-dependent unfolding dynamics of spectrin R16:Resolving experimental contradiction and unveiling model consistency 认领 引用
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作者 Wanxing Zhang Zhuwei Zhang +3 位作者 Zhenyong Xue Yuhang Zhang Shimin Le Hu Chen 《Chinese Physics B》 SCIE EI CAS CSCD 2025年第8期92-98,共7页
Spectrin domains,characterized by a distinctive triple helix structure,are crucial in physiological processes,particularly in maintaining membrane shape and crosslinking cytoskeletons.Previous research on the 16th dom... Spectrin domains,characterized by a distinctive triple helix structure,are crucial in physiological processes,particularly in maintaining membrane shape and crosslinking cytoskeletons.Previous research on the 16th domain of a-spectrin repeats(R16)has yielded conflicting results:bulk experiments showed an unfolding rate approximately two orders of magnitude faster than the zero-force result extrapolated from single-molecule force spectroscopy experiments using atomic force microscopy(AFM).To address this discrepancy,we investigated the folding and unfolding rates of R16 across a broader range of forces using magnetic tweezers(MT).Our findings reveal that AFM results at higher forces cannot be directly extrapolated to the low-force regime due to a nonlinear relationship between force and the logarithm of the unfolding rate.We demonstrated that two-dimensional model,structural-elastic model,and two-pathway model can all effectively explain the experimental data when they capture the core physics of the short unfolding distance at low forces.Our study provides a more comprehensive understanding of the unfolding dynamics of the spectrin domain,resolves previous contradictory experimental results,and highlights the common basis of different theoretical models. 展开更多
关键词 spectrin protein folding and unfolding force spectroscopy magnetic tweezers
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Symmetry-protected and Brillouin zone folding driven bound states in the continuum in dielectric nanorod arrays for efficient third harmonic generation 认领 引用
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作者 Wen-Jing Wang Shi-Jie Liang +2 位作者 Jia-Qi Zou Yan-Yan Huo Ting-Yin Ning 《Chinese Physics B》 SCIE EI CAS CSCD 2025年第3期390-398,共9页
Two types of bound states in continuum(BICs),symmetry-protected and Brillouin zone folding driven,are identified in hollow Si nanorod arrays.By modulating the direction and distance of the air holes from the center of... Two types of bound states in continuum(BICs),symmetry-protected and Brillouin zone folding driven,are identified in hollow Si nanorod arrays.By modulating the direction and distance of the air holes from the center of the nanorods,it is possible to achieve either a single quasi-BIC or three quasi-BICs.The transmission spectra exhibit ultra-narrow lines,and the quasi-BICs demonstrate ultra-high Q factors.Additionally,efficient third-harmonic generation occurs at low pump intensities.The results indicate that the proposed nanostructures of two types of BICs with a flexible modulation hold great potential applications for nonlinear photonic devices. 展开更多
关键词 bound states in the continuum Brillouin zone folding third harmonic generation
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Fast period estimation of X-ray pulsar signals using an improved fast folding algorithm 认领 引用 被引量：2
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作者 Minzhang SONG Yidi WANG +4 位作者 Wei ZHENG Liansheng LI Yusong WANG Xiaowei HU Yulong WU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2023年第10期309-316,共8页
An accurate period is important to recover the pulse profile from a recorded photon event series of an X-ray pulsar and to estimate the pulse time of arrival,which is the measurement of X-ray pulsar navigation.Epoch f... An accurate period is important to recover the pulse profile from a recorded photon event series of an X-ray pulsar and to estimate the pulse time of arrival,which is the measurement of X-ray pulsar navigation.Epoch folding is a classical period estimation method in the time domain;however,its computational complexity grows as the number of trail periods increases.In order to reduce the computational complexity,this paper improves the fast folding algorithm through segment correlation and amplitude accumulation,which is based on the post-order traversal of a binary tree.Compared with epoch folding,the improved fast folding algorithm can achieve a similar accuracy at the cost of a lower computational burden.Compared with the original fast folding algorithm,the improved algorithm can be applied to detectors with a much smaller effective area.The performance of the method is investigated by simulation data and observation data from the Neutron star Interior Composition Explorer(NICER). 展开更多
关键词 Epoch folding Fast folding algorithm Pulsar spin period Phase estimation X-ray pulsar
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A novel protein refolding method integrating ion exchange chromatography with artificial molecular chaperone 认领 引用 被引量：3
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作者 Qin Ming Zhang Chao Zhan Wang +1 位作者 Jiang Feng Liu Li Li Wang 《Chinese Chemical Letters》 SCIE CAS 2008年第5期595-598,共4页
Artificial molecular chaperone(AMC)and ion exchange chromatography(IEC)were integrated,thus a new refolding method,artificial molecular chaperone-ion exchange chromatography(AMC-IEC)was developed.Compared with AMC and... Artificial molecular chaperone(AMC)and ion exchange chromatography(IEC)were integrated,thus a new refolding method,artificial molecular chaperone-ion exchange chromatography(AMC-IEC)was developed.Compared with AMC and IEC,the activity recovery of lysozyme obtained by AMC-IEC was much higher in the investigated range of initial protein concentrations,and the results show that AMC-IEC is very efficient for protein refolding at high concentrations.When the initial concentration of lysozyme is 180 mg/mL,its activity recovery obtained by AMC-IEC is still as high as 76.6%,while the activity recoveries obtained by AMC and IEC are 45.6%and 42.4%,respectively. 展开更多
关键词 Artificial molecular chaperone Ion exchange chromatography Protein refolding Lysozyme Protein folding liquid chromatography
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论Folding/Unfolding程序转换的能力 认领 引用
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作者 朱鸿 《软件学报》 北大核心 1991年第2期31-41,共11页
本文讨论Burstall与Darlington提出的folding/unfolding系统的程序转换能力,即讨论从一个给定的程序可以推导出什么样的程序。因此,这是正确性与完备性问题的推广。本文证明了可推导性的一个必要条件,并由此得到了该系统提高程序效率的... 本文讨论Burstall与Darlington提出的folding/unfolding系统的程序转换能力,即讨论从一个给定的程序可以推导出什么样的程序。因此,这是正确性与完备性问题的推广。本文证明了可推导性的一个必要条件,并由此得到了该系统提高程序效率的一个界限。该系统的部分正确性和不完备性也均是该条件的推论。 展开更多
关键词 程序转换 Folding Unfolding
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A fast pulse phase estimation method for X-ray pulsar signals based on epoch folding 认领 引用 被引量：4
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作者 Xue Mengfan Li Xiaoping +1 位作者 Sun Haifeng Fang Haiyan 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2016年第3期746-753,共8页
X-ray pulsar-based navigation （XPNAV） is an attractive method for autonomous deep- space navigation in the future. The pulse phase estimation is a key task in XPNAV and its accuracy directly determines the navigatio... X-ray pulsar-based navigation （XPNAV） is an attractive method for autonomous deep- space navigation in the future. The pulse phase estimation is a key task in XPNAV and its accuracy directly determines the navigation accuracy. State-of-the-art pulse phase estimation techniques either suffer from poor estimation accuracy, or involve tile maximization of generally non- convex object function, thus resulting in a large computational cost. In this paper, a fasl pulse phase estimation method based on epoch folding is presented. The statistical properties of the observed profle obtained through epoch folding are developed. Based on this, we recognize the joint prob- ability distribution of the observed profile as the likelihood function and utilize a fast Fourier transform-based procedure to estimate the pulse phase. Computational complexity of the proposed estimator is analyzed as well. Experimental results show that the proposed estimator significantly outperforms the currently used cross-correlation （CC） and nonlinear least squares （NLS） estima- tors, while significantly reduces the computational complexity compared with NLS and maxinmm likelihood （ML） estimators. 展开更多
关键词 Epoch folding Maximum likelihoodPhase estimation X-ray pulsar X-ray pulsar-basednavigation （XPNAV）
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Influence of Rice Genotypes on Folding and Spinning Behaviour of Leaffolder(Cnaphalocrocis medinalis) and Its Interaction with Leaf Damage 认领 引用 被引量：6
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作者 M.PUNITHAVALLI N.M.MUTHUKRISHNAN M.BALAJI RAJKUMAR 《Rice science》 2013年第6期442-450,共9页
Folding and spinning behavior of Cnaphalocrocis medinalis （Guenee） （Lepidoptera： Pyralidae） in different categories of rice genotypes viz., resistant, susceptible, hybrid, scented, popular and wild rice genotypes... Folding and spinning behavior of Cnaphalocrocis medinalis （Guenee） （Lepidoptera： Pyralidae） in different categories of rice genotypes viz., resistant, susceptible, hybrid, scented, popular and wild rice genotypes were significantly different. Longer leaf selection time and folding time per primary fold; shorter primary fold and whole leaf fold; lower number of binds per primary fold and whole leaf fold were recorded in resistant and wild rice genotypes. In the correlation analysis, it was found that the leaf folding parameters were positively correlated to leaf folder damage whereas the leaf spinning parameters were negatively correlated. Similarly, the morphological characters differed significantly among the chosen genotypes and were related to leaffolder damage. The leaf width and total productive tiller number were positively correlated to leaffolder infestation. Results also indicated that the trichome density and length, leaf length and plant height might contribute to resistance whereas total number of green leaves had no effect on leaffolder infestation. In the scatter plot analysis between leaf folding and spinning characters and leaffolder damage, the genotypes were separated into four groups viz., resistant （TKM6, Ptb 33, LFR831311, Oryza rhizomatis and O. minuta）, moderately resistant （ASD16 and CORH1）, moderately susceptible （ADT36, Pusa Basmati and CB200290） and susceptible （IR36 and TN1）. The present investigation proved that the leaf morphology viz., leaf length and width, plant height and trichome density and length may play a vital role in resistance against rice leaffolder. 展开更多
关键词 rice genotype Cnaphalocrocis medinalis folding and spinning behaviour leaf morphology
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Investigation on the Folding Mode of a Polymer Chain in a Spiral Crystal by Single Molecule Force Spectroscopy 认领 引用 被引量：4
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作者 Yu Song Wei Feng 张文科 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2014年第9期1149-1157,共9页
Investigation on the folding mode of a single polymer chain in its crystal is significant to the understanding of the mechanism of the fundamental crystallization as well as the engineering of new polymer crystal-base... Investigation on the folding mode of a single polymer chain in its crystal is significant to the understanding of the mechanism of the fundamental crystallization as well as the engineering of new polymer crystal-based materials. Herein, we use the combined techniques of atomic force microscopy （AFM） imaging and force spectroscopy to pull a single polyethylene oxide （PEO） chain out of its spiral crystal in amyl acetate. From these data, the folding mode of polymer chains in the spiral crystal has been reconstructed. We find that the stems tilt in the typical flat area, leading to the decrease in the apparent lamellar height. While in the area of screw dislocation, the lamellar height gradually increases in the range of several nanometers. These results indicate that the combined techniques present a novel tool to directly unravel the chain folding mode of spiral crystals at single-molecule level. 展开更多
关键词 Folding mode Spiral crystal Single molecule force spectroscopy Atomic force microscopy.
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Structural Analysis of the Multi-layer Detachment Folding in Eastern Sichuan Province 认领 引用 被引量：14
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作者 WANG Zongxiu ZHANG Jin +2 位作者 LI Tao XIE Guoai MA Zongjin 《Acta Geologica Sinica(English Edition)》 SCIE CAS 2010年第3期497-514,共18页
A serial of＂comb-like and trough-like＂folds developed in eastern Sichuan,controlled by the multi-layer detachment folding,is different from the classical Jura-type structure in their development.The key factor resul... A serial of＂comb-like and trough-like＂folds developed in eastern Sichuan,controlled by the multi-layer detachment folding,is different from the classical Jura-type structure in their development.The key factor resulting in the development of these structures is the occurrence of detachment layers in different parts of Neoprotozoic to Mesozoic stratigraphy of study area,which, from the bottom to the top,are the lower part of Banxi Group,Lower Cambrian（Niutitang Formation）,Lower Silurian（Longmaxi Formation and Luoreping Formation）,Upper Permian （Wujiaping Formation） and Lower Triassic（Daye Formation）.On the basis of field survey combined with sand-box modeling,this study argued that the detachment layer of the lower part of Banxi Group controlled the development of the＂comb-like＂folds,and the lower part of Cambrian detachment layer controlled the development of＂trough-like＂folds.Because of several detachment layers occurring in the study area,the development of duplex structures different scales is an important deformation mechanism,and the duplexes are the important structures distinguished from the typical detachment folding structures.Due to these duplexes,the surface structures and structural highs may not be the structural highs in the depth.Meanwhile,the detachment layers are good channels for oil/ gas migration benefiting the understanding of accumulation and migration of oil and gas. 展开更多
关键词 multi-layer detachment folding deformation mechanism thrust tectonics eastern Sichuan
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Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells 认领 引用 被引量：5
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作者 Hong CAO Xuchang ZHOU +6 位作者 Bowen XU Han HU Jianming GUO Yuwei MA Miao WANG Nan LI Jun ZOU 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2024年第3期212-232,共21页
The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulu... The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulum.However,during protein folding,unfolded and/or misfolded proteins are prone to occur,which may lead to endoplasmic reticulum stress.Organisms can monitor the quality of the proteins produced by endoplasmic reticulum quality control(ERQC)and endoplasmic reticulum-associated degradation(ERAD),which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded proteins.The underlying mechanisms of protein folding and ERAD in mammals have not yet been fully explored.Therefore,this paper reviews the process and function of protein folding and ERAD in mammalian cells,in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD. 展开更多
关键词 Endoplasmic reticulum-associated degradation(ERAD) Protein folding Ubiquitination Retrotranslocation
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In Vitro Refolding Process of Bovine Allergen β-lactoglobulin by Multispectroscopic Method 认领 引用 被引量：1
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作者 WU Xu Li WANG Wen Pu +3 位作者 XIA Li Xin XU Hong WU Hui LIU Zhi Gang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2012年第3期334-339,共6页
Objective To characterize the relationship between the refolding process of recombinant bovine β-1actoglobulin and its immunoreactivity for clinical purposes. To establish a spectral method which examine the extent o... Objective To characterize the relationship between the refolding process of recombinant bovine β-1actoglobulin and its immunoreactivity for clinical purposes. To establish a spectral method which examine the extent of recombinant allergen renaturation. Methods The refolding process of recombinant bovine β-1actoglobulin was investigated by using circular dichroism, fluorescence and synchronous fluorescence spectra. IgE-binding capacity of recombinant protein was analyzed by ELISA. In addition, bioinformatic methods were used to explain the spectral characteristics and analyze the relationship between the conformational changes and the immunoreactivity of the protein during renaturation in vitro. Results Renaturation of recombinant bovine β-1actoglobulin resulted in a more compact structure resembling the natural counterpart with stronger IgE-binding capacity. Conclusion The degree of protein renaturation Results from this study may be of help for food future. correlated with the IgE-binding capacity of the protein. allergy therapy and development of vaccination in the 展开更多
关键词 Food allergen β-Lactoglobulin Protein folding Spectroscopy Immunoreactivity
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Design,Fabrication,and Analysis of Flapping and Folding Wing Mechanism for a Robotic Bird 认领 引用 被引量：8
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作者 Seung Wan Ryu Jong Gu Lee Hyoun Jin Kim 《Journal of Bionic Engineering》 SCIE EI CSCD 2020年第2期229-240,共12页
Emulating periodic main wing movement of a bird for generating lift and thrust remains a significant challenge in developing a robotic bird.The sequences of main wing motion are comprised of flapping,folding,bending,a... Emulating periodic main wing movement of a bird for generating lift and thrust remains a significant challenge in developing a robotic bird.The sequences of main wing motion are comprised of flapping,folding,bending,and twisting.In this paper,we concentrate on the flapping and folding motion,and design two wing mechanisms based on a 4-bar linkage structure:one is only for Flapping Motion(FM)and the other is for simultaneous Flapping and Folding Motion(FFM)during a wing stroke.We derive relationships between length and angle of links to analyze kinematic characteristics of the mechanisms and conduct an optimization to select the length parameters of links that allow maximization of the flapping angle.We run a simulation to confirm the performance of the optimized parameters by examining physical properties,and fabricate two wing mechanisms accordingly.In particular,the folding motion is achieved without using an additional actuator.Force measurements to investigate a lift profile of each mechanism and their quantitative comparison of the performance of both types confirm the benefits of the folding motion in the perspectives of wing frequency and lift.We expect that our kinematic formulation,design procedures,and comparative measurement results can help develop a wing mechanism to create a truly biomimetic robotic bird. 展开更多
关键词 biomimetic robotic bird flapping and folding wing mechanism wing kinematics force measurement
MAUN:Memory-Augmented Deep Unfolding Network for Hyperspectral Image Reconstruction 认领 引用 被引量：2
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作者 Qian Hu Jiayi Ma +2 位作者 Yuan Gao Junjun Jiang Yixuan Yuan 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第5期1139-1150,共12页
Spectral compressive imaging has emerged as a powerful technique to collect the 3D spectral information as 2D measurements.The algorithm for restoring the original 3D hyperspectral images(HSIs)from compressive measure... Spectral compressive imaging has emerged as a powerful technique to collect the 3D spectral information as 2D measurements.The algorithm for restoring the original 3D hyperspectral images(HSIs)from compressive measurements is pivotal in the imaging process.Early approaches painstakingly designed networks to directly map compressive measurements to HSIs,resulting in the lack of interpretability without exploiting the imaging priors.While some recent works have introduced the deep unfolding framework for explainable reconstruction,the performance of these methods is still limited by the weak information transmission between iterative stages.In this paper,we propose a Memory-Augmented deep Unfolding Network,termed MAUN,for explainable and accurate HSI reconstruction.Specifically,MAUN implements a novel CNN scheme to facilitate a better extrapolation step of the fast iterative shrinkage-thresholding algorithm,introducing an extra momentum incorporation step for each iteration to alleviate the information loss.Moreover,to exploit the high correlation of intermediate images from neighboring iterations,we customize a cross-stage transformer(CSFormer)as the deep denoiser to simultaneously capture self-similarity from both in-stage and cross-stage features,which is the first attempt to model the long-distance dependencies between iteration stages.Extensive experiments demonstrate that the proposed MAUN is superior to other state-of-the-art methods both visually and metrically.Our code is publicly available at http://gffzz188fe103f8f1460as5poffoq56xfw6qqf.ffgz.tsg.suse.edu.cn/HuQ1an/MAUN. 展开更多
关键词 Deep folding iteration
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Mechano-chemical selections of two competitive unfolding pathways of a single DNA i-motif 认领 引用 被引量：7
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作者 徐悦 陈虎 +5 位作者 璩玉杰 Artem K.Efremov 黎明 欧阳钟灿 刘冬生 严洁 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第6期621-628,共8页
The DNA i-motif is a quadruplex structure formed in tandem cytosine-rich sequences in slightly acidic conditions. Besides being considered as a building block of DNA nano-devices, it may also play potential roles in r... The DNA i-motif is a quadruplex structure formed in tandem cytosine-rich sequences in slightly acidic conditions. Besides being considered as a building block of DNA nano-devices, it may also play potential roles in regulating chromo- some stability and gene transcriptions. The stability of i-motif is crucial for these functions. In this work, we investigated the mechanical stability of a single i-motif formed in the human telomeric sequence 51-（CCCTAA）3CCC, which revealed a novel pH and loading rate-dependent bimodal unfolding force distribution. Although the cause of the bimodal unfolding force species is not clear, we proposed a phenomenological model involving a direct unfolding favored at lower loading rate or higher pH value, which is subject to competition with another unfolding pathway through a mechanically stable inter- mediate state whose nature is yet to be determined. Overall, the unique mechano-chemical responses of i-motif-provide a new perspective to its stability, which may be useful to guide designing new i-motif-based DNA mechanical nano-devices. 展开更多
关键词 single-molecule techniques i-motif folding/structure of biomolecules mechanical proper-ties/biomolecules
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Optimizing the Qusai-static Folding and Deploying of Thin-Walled Tube Flexure Hinges with Double Slots 认领 引用 被引量：6
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作者 YANG Hui DENG Zongquan +2 位作者 LIU Rongqiang WANG Yan GUO Hongwei 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2014年第2期279-286,共8页
The thin-walled tube flexure（TWTF） hinges have important potential application value in the deployment mechanisms of satellite and solar array, but the optimal design of the TWTF hinges haven＇t been completely solv... The thin-walled tube flexure（TWTF） hinges have important potential application value in the deployment mechanisms of satellite and solar array, but the optimal design of the TWTF hinges haven＇t been completely solved, which restricts their applications. An optimal design method for the qusai-static folding and deploying of TWTF hinges with double slots is presented based on the response surface theory. Firstly, the full factorial method is employed to design of the experiments. Then, the finite element models of the TWTF hinges with double slots are constructed to simulate the qusai-static folding and deploying non-linear analysis. What＇s more, the mathematical model of the TWTF flexure hinge quasi-static folding and deploying properties are derived by the response surface method. Considering of small mass and high stability, the peak moment of quasi-static folding and deploying as well as the lightless are set as the objectives to get the optimal performances. The relative errors of the objectives between the optimal design results and the FE analysis results are less than 7%, which demonstrates the precision of the surrogate models. Lastly, the parameter study shows that both the slots length and the slots width both have significant effects to the peak moment of quasi-static folding and deploying of TWTF hinges with double slots. However, the maximum Mises stress of quasi-static folding is more sensitive to the slots length than the slots width. The proposed research can be applied to optimize other thin-walled flexure hinges under quasi-static folding and deploying, which is of great importance to design of flexure hinges with high stability and low stress. 展开更多
关键词 design optimization quasi-static folding and deploying flexure hinges thin-walled tube response surface method,numerical simulation
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Stabilities and Dynamics of Protein Folding Nuclei by Molecular Dynamics Simulation 认领 引用 被引量：3
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作者 Yong-Shun Song Xin Zhou +1 位作者 Wei-Mou Zheng Yan-Ting Wang 《Communications in Theoretical Physics》 SCIE CAS CSCD 2017年第7期137-148,共12页
To understand how the stabilities of key nuclei fragments affect protein folding dynamics, we simulate by molecular dynamics （MD） simulation in aqueous solution four fragments cut out of a protein G, including one a... To understand how the stabilities of key nuclei fragments affect protein folding dynamics, we simulate by molecular dynamics （MD） simulation in aqueous solution four fragments cut out of a protein G, including one a-helix （seqB： KVFKQYAN）, two -turns （seqA： LNGKTLKG and seqC： YDDATKTF）, and one -strand （seqD： DGEWTYDD）. The Markov State Model clustering method combined with the coarse-grained conformation letters method are employed to analyze the data sampled from 2-#s equilibrium MD simulation trajectories. We find that seqA and seqB have more stable structures than their native structures which become metastable when cut out of the protein structure. As expected, seqD alone is flexible and does not have a stable structure. Throughout our simulations, the native structure of seqC is stable but cannot be reached if starting from a structure other than the native one, implying a funnel-shape free energy landscape of seqC in aqueous solution. All the above results suggest that different nuclei have different formation dynamics during protein folding, which may have a major contribution to the hierarchy of protein folding dynamics. 展开更多
关键词 protein folding molecular dynamics simulation structure prediction
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