The “Monitoring City Walls” research project by the University of Pisa approaches planned conservation as a process that pursues an in-depth understanding of historic city walls and their surroundings to define a sy...The “Monitoring City Walls” research project by the University of Pisa approaches planned conservation as a process that pursues an in-depth understanding of historic city walls and their surroundings to define a system of effective risk prevention. This multidisciplinary research adopts monitoring strategies and technologies at the large scale and in relationship to natural and urban conditions. The underlying logic frames the conservation of these historic fortifications within the more general mitigation of risks generated by context. The research aims to develop an innovative approach to monitoring ancient defensive structures in historical towns. The integrated use of advanced technologies allows for the control and, most importantly, advance identification of possible risks. These new technologies, in particular satellite interferometry, make it possible to improve and increase the operational capacity of monitoring processes by facilitating the acquisition and investigation of data relative to the system defined by ancient city walls and their surroundings. These technologies also represent a cost-effective tool for managing the important transition from the observation and study of individual monuments to the monitoring of large monumental complexes or even entire historical centers.展开更多
Feel for boulders while crossing the river. ---Deng Xiaoping After a 20-year track record of extraordinary successes, however, China’sleaders now confront the toughest issues since reforms began in 1978. The domes-ti...Feel for boulders while crossing the river. ---Deng Xiaoping After a 20-year track record of extraordinary successes, however, China’sleaders now confront the toughest issues since reforms began in 1978. The domes-tic economic growth rate is declining, and the surrounding region is confronting展开更多
The ancient wails of Diyarbakir are the city's most important urban etement, exhibiting an artistic grace through the arrangement of the towers, architectural values, dimensions, materiats, and decorations. Diyarbaki...The ancient wails of Diyarbakir are the city's most important urban etement, exhibiting an artistic grace through the arrangement of the towers, architectural values, dimensions, materiats, and decorations. Diyarbakir is located at the crossroads of important trade routes, one connecting the Western World to the Far East and the other connecting North to South. Architecturally, its defensive waits and towers make it one of the most important surviving casttes. In this study, the history, location, architectural and building properties of fortifications of Diyarbakir were explained and technical dimensioning typology studies on towers and city watts were submitted.展开更多
BACKGROUND Picky eating is a commonly observed behavior among children globally,negatively impacting their physical and mental growth.Although common characteristics distinguish peaky eaters,including food selectivity...BACKGROUND Picky eating is a commonly observed behavior among children globally,negatively impacting their physical and mental growth.Although common characteristics distinguish peaky eaters,including food selectivity,food neophobia,and food avoidance,there is no clear definition to assess this behavior.Due to the unavailability of data regarding picky eating,it wasn’t easy to estimate its prevalence.AIM To develop a regional protocol to help healthcare professionals identify and manage mild and moderate picky eating cases.METHODS A virtual roundtable discussion was held in April 2021 to gather the opinions of seven pediatricians and two pediatric dietitians from eight Middle Eastern countries who had great experience in the management of picky eating.The discussion covered different topics,including clearly defining mild and moderate picky eating,identifying the role of diet fortification in these cases,and the possibility of developing a systematic approach to diet fortification.RESULTS The panel identified picky eating as consuming an inadequate amount and variety of foods by rejecting familiar and unfamiliar food.Most of the time,moderate picky eating cases had micronutrient deficiencies with over-or undernutrition;the mild cases only showed inadequate food consumption and/or poor diet quality.Paying attention to the organic red flags like growth faltering and development delay and behavioral red flags,including food fixation and anticipatory gagging,will help healthcare professionals evaluate the picky eaters and the caregivers to care for their children.Although dietary supplementation and commercial food fortification play an important role in picky eating,they were no benefit in the Middle East.CONCLUSION The panel agreed that food fortification through a food-first approach and oral nutritional supplements would be the best for Middle Eastern children.These recommendations would facilitate identifying and managing picky-eating children in the Middle East.展开更多
Cucumber(Cucumis sativus L.)often experiences chilling stress that limits its growth and productivity.Grafting is widely used to improve abiotic stress resistance by exploiting a vigorous root system,suggesting there ...Cucumber(Cucumis sativus L.)often experiences chilling stress that limits its growth and productivity.Grafting is widely used to improve abiotic stress resistance by exploiting a vigorous root system,suggesting there exists systemic signals communication between distant organs.mRNAs are reported to be evolving fortification strategies involving long-distance signaling when plants suffer from chilling stress.However,the potential function of mobile mRNAs in alleviating chilling stress in grafted cucumber is still unknown.Here,the physiological changes,mobile mRNA profiles,and transcriptomic and metabolomic changes in aboveand underground tissues of all graft combinations of cucumber and pumpkin responding to chilling stress were established and analyzed comprehensively.The co-relationship between the cluster of chilling-induced pumpkin mobile mRNAs with differentially expressed genes and differentially intensive metabolites revealed that four key chilling-induced pumpkin mobile mRNAs were highly related to glycine,serine,and threonine synthesis and fatty acidβ-oxidative degradation metabolism in cucumber tissues of heterografts.The verification of mobile mRNAs,potential transport of metabolites,and exogenous application of key metabolites of the glycerophospholipid metabolism pathway in cucumber seedlings confirmed the role of mobile mRNAs in regulating chilling responses in grafted cucumber.Our results build a link between the long-distance mRNAs of chilling-tolerant pumpkin and the fatty acidβ-oxidative degradation metabolism of chilling-sensitive cucumber.They also help to uncover the mechanism of signaling interaction between scion and stock as a means of achieving chilling tolerance in grafted cucumber.展开更多
According to the Code for Seismic Design of Buildings (GB50011-2001), ten typical reinforced concrete (RC) frame structures, used as school classroom buildings, are designed with different seismic fortification in...According to the Code for Seismic Design of Buildings (GB50011-2001), ten typical reinforced concrete (RC) frame structures, used as school classroom buildings, are designed with different seismic fortification intensities (SFIs) (SFI=6 to 8.5) and different seismic design categories (SDCs) (SDC=B and C). The collapse resistance of the frames with SDC=B and C in terms of collapse fragility curves are quantitatively evaluated and compared via incremental dynamic analysis (IDA). The results show that the collapse resistance of structures should be evaluated based on both the absolute seismic resistance and the corresponding design seismic intensity. For the frames with SFI from 6 to 7.5, because they have relatively low absolute seismic resistance, their collapse resistance is insufficient even when their corresponding SDCs are upgraded from B to C. Thus, further measures are needed to enhance these structures, and some suggestions are proposed.展开更多
Objective To assess the effect of sodium iron ethylenediaminetetraacetate (NaFeEDTA)-fortified soy sauce on anemia prevalence in the Chinese population. Methods A systematic review was performed to identify potentia...Objective To assess the effect of sodium iron ethylenediaminetetraacetate (NaFeEDTA)-fortified soy sauce on anemia prevalence in the Chinese population. Methods A systematic review was performed to identify potential studies by searching the electronic databases of PubMed, Cochrane Library, WHO Library, HighWire, CNKI, and other sources. The selection criteria included randomized controlled trials that compared the efficacy of NaFeEDTA-fortified soy sauce with that of non-fortified soy sauce. Anemia rates and hemoglobin levels were the outcomes of interest. Inclusion decisions, quality assessment, and data extraction were performed by two reviewers independently. A total of 16 studies met the inclusion criteria for anemia rate analysis, of which 12 studies met the inclusion criteria for hemoglobin analysis. All included studies assessed the effect of NaFeEDTA-fortified soy sauce on anemia rates and hemoglobin concentrations. Results After the intervention, the hemoglobin concentration increased and anemia rates decreased significantly as compared with the non-fortified soy sauce groups. For anemia rates, data from 16 studies could be pooled, and the pooled estimate odds ratio was 0.25 (95% CI 0.19-0.35). For hemoglobin concentrations, data from 12 studies could be pooled, and the pooled weighted mean difference was 8.81 g/L (95% CI 5.96-11.67). Conclusion NaFeEDTA-fortified soy sauce has a positive effect on anemia control and prevention in the at-risk population.展开更多
Objective To assess the effectiveness of complementary food supplements with protein and multi-micronutrients on hemoglobin and anemia in infants and young children. Methods In 5 poor counties of Gansu, 984 children a...Objective To assess the effectiveness of complementary food supplements with protein and multi-micronutrients on hemoglobin and anemia in infants and young children. Methods In 5 poor counties of Gansu, 984 children aged 6-12 months were enrolled and divided into two groups. In addition to the usual home-made complementary food, all the children were fed one sachet of either Formula Ⅰ or Formula Ⅱ supplements each day. Protein and micronutrients were provided in Formula Ⅰ, while the same energy intake was secured in Formula Ⅱ as in Formula Ⅰ. A massive dose of vitamin A was supplemented to all the children every 6 months. Hemoglobin test was done at the same time. Results Prevalence of anemia was about 35% in both Formula Ⅰ and Formula Ⅱ group at baseline, and there were no differences in hemoglobin concentration between the two groups, During the 6-month and 12-month supplementation, hemoglobin of children in Formula Ⅰ group was higher than that in Formula Ⅱ group (P〈0.05), and hemoglobin increase in Formula Ⅰ group was significantly higher than that in Formula Ⅱ group (P〈0.001). After 6- and 12-mouth supplementation, the prevalence of anemia in Formula Ⅰ group dropped to 19.1% and 8.2% respectively, and it was 28.0% and 12.4% in Formula 2 group. The prevalence of anemia in Formula Ⅰ group was significantly lower than that in Formula Ⅱ group (P〈0.05). After adjusting age and hemoglobin level at baseline, the hemoglobin increase at age of 24 months in formula 1 group was higher (10.7 g/L vs 7.9 g/L, P〈0.0001). Conclusion Micronutrient fortified complementary food supplements, with large-dose vitamin A, is effective for children aged 6-12 months in terms of iron deficiency prevention.展开更多
Objective To observe the different impacts of electrolytic iron, FeSO4, and NaFeEDTA on body iron store of anemic school students. Methods Four hundreds anemic students at the age of 11-18 years were divided into four...Objective To observe the different impacts of electrolytic iron, FeSO4, and NaFeEDTA on body iron store of anemic school students. Methods Four hundreds anemic students at the age of 11-18 years were divided into four groups. Of which, three consumed different iron fortificants from wheat flour as food vehicle for six months and one consumed non-fortified flour (control). The fortification level of electrolytic iron, FeSO4, and NaFeEDTA was 60 mg Fe/kg, 30 mg Fe/kg, and 20 mg Fe/kg, respectively. Blood samples were collected at 0, 2, 4, and 6 months and hemoglobin (Hb), serum ferritin (SF), and transferrin receptor (TfR) were measured. Results The hemoglobin levels in three intervention groups increased, the increments of Hb in the NaFeEDTA group were significantly higher than that in the other groups. SF and TfR levels increased in the tested groups and body iron store in the NaFeEDTA group was higher than that in the other groups. These parameters did not show any significant changes in the control group. Conclusion NaFeEDTA and FeSO4 tortified wheat flour has positive impacts on iron status in anemic students and NaFeEDTA is more effective than FeSO4, while electrolytic iron is less effective in improving iron store in anemic students.展开更多
Over the past few decades,food fortification and infant formula supplementation with high levels of vitamins have led to a sharp increase in vitamin intake among infants,children and adults.This is followed by a sharp...Over the past few decades,food fortification and infant formula supplementation with high levels of vitamins have led to a sharp increase in vitamin intake among infants,children and adults.This is followed by a sharp increase in the prevalence of obesity and related diseases,with significant disparities among countries and different groups within a country.It has long been known that B vitamins at doses below their toxicity threshold strongly promote body fat gain.Studies have demonstrated that formulas,which have very high levels of vitamins,significantly promote infant weight gain,especially fat mass gain,a known risk factor for children developing obesity.Furthermore,ecological studies have shown that increased B vitamin consumption is strongly correlated with the prevalence of obesity and diabetes.We therefore hypothesize that excess vitamins may play a causal role in the increased prevalence of obesity.This review will discuss:(1)the causes of increased vitamin intake;(2)the non-monotonic effect of excess vitamin intake on weight and fat gain;and(3)the role of vitamin fortification in obesity disparities among countries and different groups within a country.展开更多
Neural tube defects(NTDs) are a group of congenital malformations of the central nervous system that are caused by the closure failure of the embryonic neural tube by the 28 th day of conception. Anencephaly and spina...Neural tube defects(NTDs) are a group of congenital malformations of the central nervous system that are caused by the closure failure of the embryonic neural tube by the 28 th day of conception. Anencephaly and spina bifida are the two major subtypes. Fetuses with anencephaly are often stillborn or electively aborted due to prenatal diagnosis, or they die shortly after birth. Most infants with spina bifida are live-born and, with proper surgical treatment, can survive into adulthood. However, these children often have life-long physical disabilities. China has one of the highest prevalence of NTDs in the world. Inadequate dietary folate intake is believed to be the main cause of the cluster. Unlike many other countries that use staple fortification with folic acid as the public health strategy to prevent NTDs, the Chinese government provides all women who have a rural household registration and who plan to become pregnant with folic acid supplements, free of charge, through a nation-wide program started in 2009. Two to three years after the initiation of the program, the folic acid supplementation rate increased to 85% in the areas of the highest NTD prevalence. The mean plasma folate level of women during early and mid-pregnancy doubled the level before the program was introduced. However, most women began taking folic acid supplements when they knew that they were pregnant. This is too late for the protection of the embryonic neural tube. In a postprogram survey of the women who reported folic acid supplementation, less than a quarter of the women began taking supplements prior to pregnancy, indicating that the remaining three quarters of the fetuses remained unprotected during the time of neural tube formation. Therefore, staple food fortification with folic acid should be considered as a priority in the prevention of NTDs.展开更多
In the late Ming period,Xu Guangqi and other Catholic literati were actively involved with military affairs because of the invasion of the Manchu forces and the threat of uprisings.The story of how they imported Europ...In the late Ming period,Xu Guangqi and other Catholic literati were actively involved with military affairs because of the invasion of the Manchu forces and the threat of uprisings.The story of how they imported European cannons and gunners from Macao is now quite famous.However,the introduction of European fortifications,mainly the trace Italienne,in the same period is still relatively unknown.Xu Guangqi and his student Sun Yuanhua exerted considerable efforts in advocating European-style bastions.Xu not only received help from Jesuits,but also support from some Fujianese who were familiar with Intramuros,the Spanish walled city of Manila.In addition to Xu and Sun,Han Lin and Han Yun(also Xu’s students)prepared a Chinese treatise on European fortification architecture based on Italian sources and tried to put the knowledge into practice.Another relevant figure is Ma Weicheng,who allegedly directed the building of 32 angled bastions in three cities around 1640.Although a few recorded writings and practices of constructing European-style fortification appeared in the first half of the seventeenth century,soon afterwards the art of trace Italienne met its end prematurely in China.To a great extent,the swift collapse of the Ming dynasty eliminated the possibility of spreading the new defense technology.Throughout the eighteenth century,the Qing dynasty enjoyed long-term peace,and the warfare at the frontiers brought few threats to the city walls.There was thus little urgency to develop innovative defensive works and European fortification sunk into oblivion until the mid-nineteenth century.展开更多
This paper introduces the characteristics of earthquake disasters in the 2013 Urumqi MS5. 1 and the 2015 Pishan MS6. 5 earthquakes,which are directly beneath the cities. Based on the discussion on regional tectonic ba...This paper introduces the characteristics of earthquake disasters in the 2013 Urumqi MS5. 1 and the 2015 Pishan MS6. 5 earthquakes,which are directly beneath the cities. Based on the discussion on regional tectonic background,site conditions,seismic fortification level of buildings,we preliminarily analyzed the causes of earthquake disaster for buildings caused by the two earthquakes. Finally,we give some advice on earthquake resistance for residential buildings and earthquake damage prevention in Xinjiang.展开更多
A multi-objective lectotype optimization model based on site conditions and seismic fortification intensity is presented for mid-highrise residential buildings taking into account multiple items such as the original i...A multi-objective lectotype optimization model based on site conditions and seismic fortification intensity is presented for mid-highrise residential buildings taking into account multiple items such as the original investment, disaster losses and maintenance cost, the integral stiffness, the total ductility, the construction period, and so on. A Three-Scale Fuzzy Analytical Hierarchy process is proposed by introducing the Three-Scale Analytical Hierarchy process and the trapezoid fuzzy number. The result of a calculation example shows that the T-FAHP is practical.展开更多
API code is introduced at first, and then a comparison of seismic character and seismic hazard between Bohai and Southern California is carried out. The analysis indicates both the seismic frequency and intensity and ...API code is introduced at first, and then a comparison of seismic character and seismic hazard between Bohai and Southern California is carried out. The analysis indicates both the seismic frequency and intensity and the seismic hazard of Bohai are much weaker than that of Southern California. API code states the strength level and deformation level of permanent structures in Southern California takes 200 a and several hundred to a few thousand years respectively. But in the reference codes in China, the seismic levels take 500 a and 10000 a for strength design and deformation design, and it seems too conservative. In China, the deformation level of class A structure takes 2%-3% probabilities of exceedance in reference period 100 a, and that of class B and C often takes 2%-3% in 50 a. Now that offshore platforms may cause server subsequent risk, it is safe to take 1% in 30 a as its deformation design level. On the basis of the above analyses and social economic level and the consistency with present codes, the strength design level and deformation design level of Chinese offshore platforms is suggested to take 200 a and 3000 a respectively.展开更多
The seismic design criterion adopted in the existing seismic design codes is reviewed. It is pointed out that the presently used seismic design criterion is not satisfied with the requirements of nowadays social and e...The seismic design criterion adopted in the existing seismic design codes is reviewed. It is pointed out that the presently used seismic design criterion is not satisfied with the requirements of nowadays social and economic development. A new performance-based seismic design criterion that is composed of three components is presented in this paper. It can not only effectively control the economic losses and casualty, but also ensure the building's function in proper operation during earthquakes. The three components are: classification of seismic design for buildings, determination of seismic design intensity and/or seismic design ground motion for controlling seismic economic losses and casualties, and determination of the importance factors in terms of service periods of buildings. For controlling the seismic human losses, the idea of socially acceptable casualty level is presented and the 'Optimal Economic Decision Model' and 'Optimal Safe Decision Model' are established. Finally, a new method is recommended for calculating the importance factors of structures by adjusting structures service period on the base of more important structure with longer service period than the conventional ones. Therefore, the more important structure with longer service periods will be designed for higher seismic loads, in case the exceedance probability of seismic hazard in different service period is same.展开更多
This paper discusses the relation between two-step seismic design and the standard of probability of exceedance, and the relation of three-levels seismic ground motion parameters given by probability method and compre...This paper discusses the relation between two-step seismic design and the standard of probability of exceedance, and the relation of three-levels seismic ground motion parameters given by probability method and comprehensive probability method. The relative size relations of the ground motions with 2%, 10%, 63% probability of exceedance in 50 years, namely large earthquake, moderate earthquake, and small earthquake, are discussed through a practical example of seismic hazard analysis. The methods to determine seismic fortification criterion are discussed.展开更多
It is of great significance to make comparative analyses of seismic fortification criteria at home and abroad for improving the anti-seismic capability of electrical equipment and revising the relevant national standa...It is of great significance to make comparative analyses of seismic fortification criteria at home and abroad for improving the anti-seismic capability of electrical equipment and revising the relevant national standards.A brief overview of American,Japanese,IEC standards and Chinese seismic design codes for electrical equipment is presented.Differences between these seismic fortification standards of electrical equipment are compared and analyzed in respect of the goal and level of seismic fortification and the seismic design spectrum.The advantages and disadvantages of Chinese standards are pointed out.Through learning from foreign experience on the determination of seismic fortification standards,recommendations are made for the improvement and revision of Chinese seismic fortification standards for electrical equipment.展开更多
Elevation of acid degree values (ADV) and peroxide value (POV) indicates deterioration of nutritional and sensory qualities of dairy products during storage. Iron fortification in bovine milk cheeses in relation to li...Elevation of acid degree values (ADV) and peroxide value (POV) indicates deterioration of nutritional and sensory qualities of dairy products during storage. Iron fortification in bovine milk cheeses in relation to lipolytic parameters and their correlations have been studied, while no such studies have been reported on caprine milk cheeses. The objectives of this study were to evaluate levels of ADV and POV of iron fortified [regular ferrous sulfate (RFS) and large microencapsulated ferrous sulfate (LMFS)] goat milk Cheddar cheeses compared to those of non-fortified control cheese (CC) and their correlations. Three batches of 3 types (CC, RFS and LMFS added) of goat milk cheeses were manufactured and stored at two temperatures (4°C and -18°C) for 0, 2 and 4 months. Iron was supplemented to RFS and LMFS cheeses by 8.23 g and 9.03 g per 9 kg, respectively. ADV and POV were determined using standard methods of examining dairy products (Richardson, 1985) and AOCS (1975) procedures. Results showed that ADV values for CC, RFS and LMFS cheeses for 0 and 4 month storage at 4°C were: 0.67, 0.73, 0.64;1.24, 1.78, 1.58, respectively, indicating significant (P < 0.05) elevations occurred in ADV for all three cheeses during 4 months storage. The cheese samples at 4 months storage showed significantly (P < 0.05) higher peroxide values compared to 0 and 2 month stored ones. The samples stored at refrigeration temperature (4°C) revealed slightly more lipid oxidation than those stored at frozen temperature (-18°C). Significant (P < 0.05) elevations in POV for all goat cheeses stored for 4 months and slight increases in POV at higher temperature implies that the longer time and higher temperature storage can elevate the rate of lipid oxidation in goat milk Cheddar cheeses. Correlations (r) between ADV and POV for the pooled data of three types of the caprine cheeses across storage periods were significant (P < 0.01), while r values of CC cheeses alone were negative. It was concluded that significant correlations exist between extents of lipolysis and lipid oxidation in the caprine milk Cheddar cheeses during 4 months storage.展开更多
基金Thanks to Jacinto E.Canivell Garcia De Paredes,Emilio Jose Mascort Albea and Rocio Romero Hernandez at the University of Seville for the support provided in defining the digital mapping instruments.
摘要The “Monitoring City Walls” research project by the University of Pisa approaches planned conservation as a process that pursues an in-depth understanding of historic city walls and their surroundings to define a system of effective risk prevention. This multidisciplinary research adopts monitoring strategies and technologies at the large scale and in relationship to natural and urban conditions. The underlying logic frames the conservation of these historic fortifications within the more general mitigation of risks generated by context. The research aims to develop an innovative approach to monitoring ancient defensive structures in historical towns. The integrated use of advanced technologies allows for the control and, most importantly, advance identification of possible risks. These new technologies, in particular satellite interferometry, make it possible to improve and increase the operational capacity of monitoring processes by facilitating the acquisition and investigation of data relative to the system defined by ancient city walls and their surroundings. These technologies also represent a cost-effective tool for managing the important transition from the observation and study of individual monuments to the monitoring of large monumental complexes or even entire historical centers.
摘要Feel for boulders while crossing the river. ---Deng Xiaoping After a 20-year track record of extraordinary successes, however, China’sleaders now confront the toughest issues since reforms began in 1978. The domes-tic economic growth rate is declining, and the surrounding region is confronting
摘要The ancient wails of Diyarbakir are the city's most important urban etement, exhibiting an artistic grace through the arrangement of the towers, architectural values, dimensions, materiats, and decorations. Diyarbakir is located at the crossroads of important trade routes, one connecting the Western World to the Far East and the other connecting North to South. Architecturally, its defensive waits and towers make it one of the most important surviving casttes. In this study, the history, location, architectural and building properties of fortifications of Diyarbakir were explained and technical dimensioning typology studies on towers and city watts were submitted.
摘要BACKGROUND Picky eating is a commonly observed behavior among children globally,negatively impacting their physical and mental growth.Although common characteristics distinguish peaky eaters,including food selectivity,food neophobia,and food avoidance,there is no clear definition to assess this behavior.Due to the unavailability of data regarding picky eating,it wasn’t easy to estimate its prevalence.AIM To develop a regional protocol to help healthcare professionals identify and manage mild and moderate picky eating cases.METHODS A virtual roundtable discussion was held in April 2021 to gather the opinions of seven pediatricians and two pediatric dietitians from eight Middle Eastern countries who had great experience in the management of picky eating.The discussion covered different topics,including clearly defining mild and moderate picky eating,identifying the role of diet fortification in these cases,and the possibility of developing a systematic approach to diet fortification.RESULTS The panel identified picky eating as consuming an inadequate amount and variety of foods by rejecting familiar and unfamiliar food.Most of the time,moderate picky eating cases had micronutrient deficiencies with over-or undernutrition;the mild cases only showed inadequate food consumption and/or poor diet quality.Paying attention to the organic red flags like growth faltering and development delay and behavioral red flags,including food fixation and anticipatory gagging,will help healthcare professionals evaluate the picky eaters and the caregivers to care for their children.Although dietary supplementation and commercial food fortification play an important role in picky eating,they were no benefit in the Middle East.CONCLUSION The panel agreed that food fortification through a food-first approach and oral nutritional supplements would be the best for Middle Eastern children.These recommendations would facilitate identifying and managing picky-eating children in the Middle East.
基金the National Key Research and Development Program of China(2018YFD1000800 and 2019YFD1000300)to WN Zhangthe National Natural Science Foundation of China(31872158)to WN Zhang+1 种基金Fundamental Research Funds for‘Talent Cultivation and Development Plan’of China Agricultural University(00109016)China Agriculture Research System of MOF and MARA to LH Gao.
摘要Cucumber(Cucumis sativus L.)often experiences chilling stress that limits its growth and productivity.Grafting is widely used to improve abiotic stress resistance by exploiting a vigorous root system,suggesting there exists systemic signals communication between distant organs.mRNAs are reported to be evolving fortification strategies involving long-distance signaling when plants suffer from chilling stress.However,the potential function of mobile mRNAs in alleviating chilling stress in grafted cucumber is still unknown.Here,the physiological changes,mobile mRNA profiles,and transcriptomic and metabolomic changes in aboveand underground tissues of all graft combinations of cucumber and pumpkin responding to chilling stress were established and analyzed comprehensively.The co-relationship between the cluster of chilling-induced pumpkin mobile mRNAs with differentially expressed genes and differentially intensive metabolites revealed that four key chilling-induced pumpkin mobile mRNAs were highly related to glycine,serine,and threonine synthesis and fatty acidβ-oxidative degradation metabolism in cucumber tissues of heterografts.The verification of mobile mRNAs,potential transport of metabolites,and exogenous application of key metabolites of the glycerophospholipid metabolism pathway in cucumber seedlings confirmed the role of mobile mRNAs in regulating chilling responses in grafted cucumber.Our results build a link between the long-distance mRNAs of chilling-tolerant pumpkin and the fatty acidβ-oxidative degradation metabolism of chilling-sensitive cucumber.They also help to uncover the mechanism of signaling interaction between scion and stock as a means of achieving chilling tolerance in grafted cucumber.
基金National Science Foundation of China Under Grant No.90815025&51178249the National Key Technologies R&D Program Under Grant No.2009BAJ28B01&2006BAJ03A02-01+1 种基金Tsinghua University Research Funds No.2010THZ02-1the Program for New Century Excellent Talents in University
摘要According to the Code for Seismic Design of Buildings (GB50011-2001), ten typical reinforced concrete (RC) frame structures, used as school classroom buildings, are designed with different seismic fortification intensities (SFIs) (SFI=6 to 8.5) and different seismic design categories (SDCs) (SDC=B and C). The collapse resistance of the frames with SDC=B and C in terms of collapse fragility curves are quantitatively evaluated and compared via incremental dynamic analysis (IDA). The results show that the collapse resistance of structures should be evaluated based on both the absolute seismic resistance and the corresponding design seismic intensity. For the frames with SFI from 6 to 7.5, because they have relatively low absolute seismic resistance, their collapse resistance is insufficient even when their corresponding SDCs are upgraded from B to C. Thus, further measures are needed to enhance these structures, and some suggestions are proposed.
基金supported by National Special Fund for Health(No.201202012)
摘要Objective To assess the effect of sodium iron ethylenediaminetetraacetate (NaFeEDTA)-fortified soy sauce on anemia prevalence in the Chinese population. Methods A systematic review was performed to identify potential studies by searching the electronic databases of PubMed, Cochrane Library, WHO Library, HighWire, CNKI, and other sources. The selection criteria included randomized controlled trials that compared the efficacy of NaFeEDTA-fortified soy sauce with that of non-fortified soy sauce. Anemia rates and hemoglobin levels were the outcomes of interest. Inclusion decisions, quality assessment, and data extraction were performed by two reviewers independently. A total of 16 studies met the inclusion criteria for anemia rate analysis, of which 12 studies met the inclusion criteria for hemoglobin analysis. All included studies assessed the effect of NaFeEDTA-fortified soy sauce on anemia rates and hemoglobin concentrations. Results After the intervention, the hemoglobin concentration increased and anemia rates decreased significantly as compared with the non-fortified soy sauce groups. For anemia rates, data from 16 studies could be pooled, and the pooled estimate odds ratio was 0.25 (95% CI 0.19-0.35). For hemoglobin concentrations, data from 12 studies could be pooled, and the pooled weighted mean difference was 8.81 g/L (95% CI 5.96-11.67). Conclusion NaFeEDTA-fortified soy sauce has a positive effect on anemia control and prevention in the at-risk population.
摘要Objective To assess the effectiveness of complementary food supplements with protein and multi-micronutrients on hemoglobin and anemia in infants and young children. Methods In 5 poor counties of Gansu, 984 children aged 6-12 months were enrolled and divided into two groups. In addition to the usual home-made complementary food, all the children were fed one sachet of either Formula Ⅰ or Formula Ⅱ supplements each day. Protein and micronutrients were provided in Formula Ⅰ, while the same energy intake was secured in Formula Ⅱ as in Formula Ⅰ. A massive dose of vitamin A was supplemented to all the children every 6 months. Hemoglobin test was done at the same time. Results Prevalence of anemia was about 35% in both Formula Ⅰ and Formula Ⅱ group at baseline, and there were no differences in hemoglobin concentration between the two groups, During the 6-month and 12-month supplementation, hemoglobin of children in Formula Ⅰ group was higher than that in Formula Ⅱ group (P〈0.05), and hemoglobin increase in Formula Ⅰ group was significantly higher than that in Formula Ⅱ group (P〈0.001). After 6- and 12-mouth supplementation, the prevalence of anemia in Formula Ⅰ group dropped to 19.1% and 8.2% respectively, and it was 28.0% and 12.4% in Formula 2 group. The prevalence of anemia in Formula Ⅰ group was significantly lower than that in Formula Ⅱ group (P〈0.05). After adjusting age and hemoglobin level at baseline, the hemoglobin increase at age of 24 months in formula 1 group was higher (10.7 g/L vs 7.9 g/L, P〈0.0001). Conclusion Micronutrient fortified complementary food supplements, with large-dose vitamin A, is effective for children aged 6-12 months in terms of iron deficiency prevention.
基金supported by the Center for Health Promotion, International Life Sciences Institute
摘要Objective To observe the different impacts of electrolytic iron, FeSO4, and NaFeEDTA on body iron store of anemic school students. Methods Four hundreds anemic students at the age of 11-18 years were divided into four groups. Of which, three consumed different iron fortificants from wheat flour as food vehicle for six months and one consumed non-fortified flour (control). The fortification level of electrolytic iron, FeSO4, and NaFeEDTA was 60 mg Fe/kg, 30 mg Fe/kg, and 20 mg Fe/kg, respectively. Blood samples were collected at 0, 2, 4, and 6 months and hemoglobin (Hb), serum ferritin (SF), and transferrin receptor (TfR) were measured. Results The hemoglobin levels in three intervention groups increased, the increments of Hb in the NaFeEDTA group were significantly higher than that in the other groups. SF and TfR levels increased in the tested groups and body iron store in the NaFeEDTA group was higher than that in the other groups. These parameters did not show any significant changes in the control group. Conclusion NaFeEDTA and FeSO4 tortified wheat flour has positive impacts on iron status in anemic students and NaFeEDTA is more effective than FeSO4, while electrolytic iron is less effective in improving iron store in anemic students.
摘要Over the past few decades,food fortification and infant formula supplementation with high levels of vitamins have led to a sharp increase in vitamin intake among infants,children and adults.This is followed by a sharp increase in the prevalence of obesity and related diseases,with significant disparities among countries and different groups within a country.It has long been known that B vitamins at doses below their toxicity threshold strongly promote body fat gain.Studies have demonstrated that formulas,which have very high levels of vitamins,significantly promote infant weight gain,especially fat mass gain,a known risk factor for children developing obesity.Furthermore,ecological studies have shown that increased B vitamin consumption is strongly correlated with the prevalence of obesity and diabetes.We therefore hypothesize that excess vitamins may play a causal role in the increased prevalence of obesity.This review will discuss:(1)the causes of increased vitamin intake;(2)the non-monotonic effect of excess vitamin intake on weight and fat gain;and(3)the role of vitamin fortification in obesity disparities among countries and different groups within a country.
摘要Neural tube defects(NTDs) are a group of congenital malformations of the central nervous system that are caused by the closure failure of the embryonic neural tube by the 28 th day of conception. Anencephaly and spina bifida are the two major subtypes. Fetuses with anencephaly are often stillborn or electively aborted due to prenatal diagnosis, or they die shortly after birth. Most infants with spina bifida are live-born and, with proper surgical treatment, can survive into adulthood. However, these children often have life-long physical disabilities. China has one of the highest prevalence of NTDs in the world. Inadequate dietary folate intake is believed to be the main cause of the cluster. Unlike many other countries that use staple fortification with folic acid as the public health strategy to prevent NTDs, the Chinese government provides all women who have a rural household registration and who plan to become pregnant with folic acid supplements, free of charge, through a nation-wide program started in 2009. Two to three years after the initiation of the program, the folic acid supplementation rate increased to 85% in the areas of the highest NTD prevalence. The mean plasma folate level of women during early and mid-pregnancy doubled the level before the program was introduced. However, most women began taking folic acid supplements when they knew that they were pregnant. This is too late for the protection of the embryonic neural tube. In a postprogram survey of the women who reported folic acid supplementation, less than a quarter of the women began taking supplements prior to pregnancy, indicating that the remaining three quarters of the fetuses remained unprotected during the time of neural tube formation. Therefore, staple food fortification with folic acid should be considered as a priority in the prevention of NTDs.
摘要In the late Ming period,Xu Guangqi and other Catholic literati were actively involved with military affairs because of the invasion of the Manchu forces and the threat of uprisings.The story of how they imported European cannons and gunners from Macao is now quite famous.However,the introduction of European fortifications,mainly the trace Italienne,in the same period is still relatively unknown.Xu Guangqi and his student Sun Yuanhua exerted considerable efforts in advocating European-style bastions.Xu not only received help from Jesuits,but also support from some Fujianese who were familiar with Intramuros,the Spanish walled city of Manila.In addition to Xu and Sun,Han Lin and Han Yun(also Xu’s students)prepared a Chinese treatise on European fortification architecture based on Italian sources and tried to put the knowledge into practice.Another relevant figure is Ma Weicheng,who allegedly directed the building of 32 angled bastions in three cities around 1640.Although a few recorded writings and practices of constructing European-style fortification appeared in the first half of the seventeenth century,soon afterwards the art of trace Italienne met its end prematurely in China.To a great extent,the swift collapse of the Ming dynasty eliminated the possibility of spreading the new defense technology.Throughout the eighteenth century,the Qing dynasty enjoyed long-term peace,and the warfare at the frontiers brought few threats to the city walls.There was thus little urgency to develop innovative defensive works and European fortification sunk into oblivion until the mid-nineteenth century.
基金the Special Fund for Earthquake Scientific Research of CEA(201308018)
摘要This paper introduces the characteristics of earthquake disasters in the 2013 Urumqi MS5. 1 and the 2015 Pishan MS6. 5 earthquakes,which are directly beneath the cities. Based on the discussion on regional tectonic background,site conditions,seismic fortification level of buildings,we preliminarily analyzed the causes of earthquake disaster for buildings caused by the two earthquakes. Finally,we give some advice on earthquake resistance for residential buildings and earthquake damage prevention in Xinjiang.
摘要A multi-objective lectotype optimization model based on site conditions and seismic fortification intensity is presented for mid-highrise residential buildings taking into account multiple items such as the original investment, disaster losses and maintenance cost, the integral stiffness, the total ductility, the construction period, and so on. A Three-Scale Fuzzy Analytical Hierarchy process is proposed by introducing the Three-Scale Analytical Hierarchy process and the trapezoid fuzzy number. The result of a calculation example shows that the T-FAHP is practical.
基金Important Research of the Tenth Five-year Plan from China Earthquake Administration ″Seismic hazard assessment and structure seismic fortification″ and ″Reliability of seismic fortification level of offshore platforms″.
摘要API code is introduced at first, and then a comparison of seismic character and seismic hazard between Bohai and Southern California is carried out. The analysis indicates both the seismic frequency and intensity and the seismic hazard of Bohai are much weaker than that of Southern California. API code states the strength level and deformation level of permanent structures in Southern California takes 200 a and several hundred to a few thousand years respectively. But in the reference codes in China, the seismic levels take 500 a and 10000 a for strength design and deformation design, and it seems too conservative. In China, the deformation level of class A structure takes 2%-3% probabilities of exceedance in reference period 100 a, and that of class B and C often takes 2%-3% in 50 a. Now that offshore platforms may cause server subsequent risk, it is safe to take 1% in 30 a as its deformation design level. On the basis of the above analyses and social economic level and the consistency with present codes, the strength design level and deformation design level of Chinese offshore platforms is suggested to take 200 a and 3000 a respectively.
基金Chinese National Natural Science Foundation with the grant No.59895410the China Basic Research and Development Project:the Mechanism and Prediction of the Strong Earthquake of the Continental under the Grant No.95130603
摘要The seismic design criterion adopted in the existing seismic design codes is reviewed. It is pointed out that the presently used seismic design criterion is not satisfied with the requirements of nowadays social and economic development. A new performance-based seismic design criterion that is composed of three components is presented in this paper. It can not only effectively control the economic losses and casualty, but also ensure the building's function in proper operation during earthquakes. The three components are: classification of seismic design for buildings, determination of seismic design intensity and/or seismic design ground motion for controlling seismic economic losses and casualties, and determination of the importance factors in terms of service periods of buildings. For controlling the seismic human losses, the idea of socially acceptable casualty level is presented and the 'Optimal Economic Decision Model' and 'Optimal Safe Decision Model' are established. Finally, a new method is recommended for calculating the importance factors of structures by adjusting structures service period on the base of more important structure with longer service period than the conventional ones. Therefore, the more important structure with longer service periods will be designed for higher seismic loads, in case the exceedance probability of seismic hazard in different service period is same.
摘要This paper discusses the relation between two-step seismic design and the standard of probability of exceedance, and the relation of three-levels seismic ground motion parameters given by probability method and comprehensive probability method. The relative size relations of the ground motions with 2%, 10%, 63% probability of exceedance in 50 years, namely large earthquake, moderate earthquake, and small earthquake, are discussed through a practical example of seismic hazard analysis. The methods to determine seismic fortification criterion are discussed.
基金funded by the special project of Spark Program of Earthquake Sciences (Serial number:XH12063)
摘要It is of great significance to make comparative analyses of seismic fortification criteria at home and abroad for improving the anti-seismic capability of electrical equipment and revising the relevant national standards.A brief overview of American,Japanese,IEC standards and Chinese seismic design codes for electrical equipment is presented.Differences between these seismic fortification standards of electrical equipment are compared and analyzed in respect of the goal and level of seismic fortification and the seismic design spectrum.The advantages and disadvantages of Chinese standards are pointed out.Through learning from foreign experience on the determination of seismic fortification standards,recommendations are made for the improvement and revision of Chinese seismic fortification standards for electrical equipment.
摘要Elevation of acid degree values (ADV) and peroxide value (POV) indicates deterioration of nutritional and sensory qualities of dairy products during storage. Iron fortification in bovine milk cheeses in relation to lipolytic parameters and their correlations have been studied, while no such studies have been reported on caprine milk cheeses. The objectives of this study were to evaluate levels of ADV and POV of iron fortified [regular ferrous sulfate (RFS) and large microencapsulated ferrous sulfate (LMFS)] goat milk Cheddar cheeses compared to those of non-fortified control cheese (CC) and their correlations. Three batches of 3 types (CC, RFS and LMFS added) of goat milk cheeses were manufactured and stored at two temperatures (4°C and -18°C) for 0, 2 and 4 months. Iron was supplemented to RFS and LMFS cheeses by 8.23 g and 9.03 g per 9 kg, respectively. ADV and POV were determined using standard methods of examining dairy products (Richardson, 1985) and AOCS (1975) procedures. Results showed that ADV values for CC, RFS and LMFS cheeses for 0 and 4 month storage at 4°C were: 0.67, 0.73, 0.64;1.24, 1.78, 1.58, respectively, indicating significant (P < 0.05) elevations occurred in ADV for all three cheeses during 4 months storage. The cheese samples at 4 months storage showed significantly (P < 0.05) higher peroxide values compared to 0 and 2 month stored ones. The samples stored at refrigeration temperature (4°C) revealed slightly more lipid oxidation than those stored at frozen temperature (-18°C). Significant (P < 0.05) elevations in POV for all goat cheeses stored for 4 months and slight increases in POV at higher temperature implies that the longer time and higher temperature storage can elevate the rate of lipid oxidation in goat milk Cheddar cheeses. Correlations (r) between ADV and POV for the pooled data of three types of the caprine cheeses across storage periods were significant (P < 0.01), while r values of CC cheeses alone were negative. It was concluded that significant correlations exist between extents of lipolysis and lipid oxidation in the caprine milk Cheddar cheeses during 4 months storage.