Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value ...Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification.展开更多
This paper introduces a novel fractional-order model based on the Caputo-Fabrizio(CF)derivative for analyzing computer virus propagation in networked environments.The model partitions the computer population into four...This paper introduces a novel fractional-order model based on the Caputo-Fabrizio(CF)derivative for analyzing computer virus propagation in networked environments.The model partitions the computer population into four compartments:susceptible,latently infected,breaking-out,and antivirus-capable systems.By employing the CF derivative—which uses a nonsingular exponential kernel—the framework effectively captures memory-dependent and nonlocal characteristics intrinsic to cyber systems,aspects inadequately represented by traditional integer-order models.Under Lipschitz continuity and boundedness assumptions,the existence and uniqueness of solutions are rigorously established via fixed-point theory.We develop a tailored two-step Adams-Bashforth numerical scheme for the CF framework and prove its second-order accuracy.Extensive numerical simulations across various fractional orders reveal that memory effects significantly influence virus transmission and control dynamics;smaller fractional orders produce more pronounced memory effects,delaying both infection spread and antivirus activation.Further theoretical analysis,including Hyers-Ulam stability and sensitivity assessments,reinforces the model’s robustness and identifies key parameters governing virus dynamics.The study also extends the framework to incorporate stochastic effects through a stochastic CF formulation.These results underscore fractional-order modeling as a powerful analytical tool for developing robust and effective cybersecurity strategies.展开更多
Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In ...Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In this study,the effect of land use type on carbon storage and fractionation was quantified based on organic carbon and its13C abundance at the microscale of soil aggregates and density fractions in Tibetan alpine ecosystems.The sequence of soil aggregate destruction in the land use types of plantation(13.1%)<shrubland(32.7%)<grassland(47.9%)<farmland(61.8%)shows that plantations strengthen the soil structure.Plantation land had a greater contribution of light fraction organic carbon(28.3%)but a lower contribution of mineral-associated organic carbon(40.6%)to the carbon stock compared to farmland(13.5 and 70.3%).Interestingly,plantation land enhanced the aggregational differentiation of organic carbon and13C in each density fraction,whereas no such phenomenon existed in the soil organic carbon.Carbon isotope analyses revealed that carbon transfer in the plantation land occurred from the light fraction in macroaggregates(–24.9‰)to the mineral-associated fraction in microaggregates(–19.9‰).When compared to the other three land use types,the low transferability of carbon in aggregates and density fractions in plantation land provides a stable carbon pool for the Tibetan Plateau.This study shows that plantations can mitigate global climate change by slowing carbon transfer and increasing carbon storage at the microscale of aggregates and density fractions in alpine regions.展开更多
In this paper,the new solitary wave solutions of the fractional doubly dispersive equation(FDDE)are investigated.These solutions are used in demonstrating wave transmission in elastic inhomogeneous Murnaghan’s rod.A ...In this paper,the new solitary wave solutions of the fractional doubly dispersive equation(FDDE)are investigated.These solutions are used in demonstrating wave transmission in elastic inhomogeneous Murnaghan’s rod.A very effective method,known as the unified method,is used here to obtain these solutions.In different conditions,the obtained solutions exhibit different pulse patterns including bright,periodic,combined bright-dark,two-soliton interaction,three-soliton interaction,five-soliton interaction,w-shaped,m-shaped,and u-shaped solutions.These physical characteristics are thoroughly investigated by the graphical representation under different values of the parameters which shows the reliability and productivity of the proposed method.In addition,linear stability analysis is applied to analyse the stability of the considered model.The novel aspect of this study is that the investigated model has never been studied by using the proposed method,and the resulting solutions have never been accomplished previously.展开更多
Interpretation of coronary physiology with fractional flow reserve(FFR)assumes stable relationships between flow,demand,and resistance,but conduction abnormalities such as left bundle branch block(LBBB)can disrupt myo...Interpretation of coronary physiology with fractional flow reserve(FFR)assumes stable relationships between flow,demand,and resistance,but conduction abnormalities such as left bundle branch block(LBBB)can disrupt myocardial activation,perfusion,and pressure-derived ischemic indices especially in aged patients.[1]Heart rate related LBBB is a transient,rate-dependent conduction delay that induces ventricular dyssynchrony and impairs regional perfusion,potentially altering instantaneous FFR(iFFR)accuracy,particularly in the left anterior descending artery or the left circumflex artery disease.[2]Because the physiological impact of heart rate related LBBB is unknown,we investigated its influence on iFFR in aged patients with intermediate stenoses in the left coronary artery.展开更多
BACKGROUND Obesity-related heart failure with preserved ejection fraction(HFpEF)is highly prevalent,symptomatically disabling,and lacks clearly disease-modifying pharmacotherapy.Glucagon-like peptide(GLP)-1-based incr...BACKGROUND Obesity-related heart failure with preserved ejection fraction(HFpEF)is highly prevalent,symptomatically disabling,and lacks clearly disease-modifying pharmacotherapy.Glucagon-like peptide(GLP)-1-based incretin agonists-including GLP-1 receptor agonists(GLP-1 RAs;e.g.,semaglutide)and the dual GIP/GLP-1 RA tirzepatide-induce substantial weight loss and favorable cardiometabolic effects and have recently been evaluated in obese HFpEF populations.AIM To systematically evaluate the efficacy and safety of GLP-1–based incretin agonists(including GLP-1 RAs and the dual GIP/GLP-1 RA tirzepatide)in patients with obesity-related HFpEF and to quantify their effects through meta-analysis.METHODS PubMed/MEDLINE,EMBASE,Cochrane CENTRAL,and Web of Science were searched from inception to October 2025 for randomized controlled trials(RCT)evaluating GLP-1–based incretin agonist therapy in adults with HFpEF and obesity.Outcomes included health status[Kansas City Cardiomyopathy Questionnaire clinical summary score(KCCQ-CSS)],body weight,exercise capacity,heart failure events,and safety.Risk of bias was assessed using the Cochrane Risk of Bias 2 tool.Random-effects meta-analyses were performed for KCCQ-CSS and percentage body weight change.RESULTS Three RCTs(n=1876)were included in quantitative synthesis:STEP-HFpEF(n=529),STEP-HFpEF DM(n=616),and SUMMIT(n=731).GLP-1-based incretin agonist therapy significantly improved health status,with a pooled increase in KCCQ-CSS of+7.33 points[95%confidence interval(CI):5.84 to 8.82;I²=0%].Substantial weight loss was observed,with a pooled reduction of-9.56 percentage points(95%CI:-12.15 to-6.97;I²=58%).Tirzepatide significantly reduced the composite of cardiovascular(CV)death or worsening heart failure event(hazard ratio 0.62,95%CI:0.41-0.95;P=0.026),while semaglutide trials demonstrated consistent favorable trends.Across trials,GLP-1-based therapies improved exercise capacity and were associated with fewer serious adverse events,with gastrointestinal symptoms being the most common side effect.CONCLUSION GLP-1-based incretin agonists produce clinically meaningful improvements in symptoms,functional capacity,and body weight in patients with obesity-related HFpEF,with consistent benefit across trials and acceptable safety.Meta-analysis confirms robust improvement in health status and substantial weight reduction,supporting this therapeutic class as a promising disease-modifying strategy for this high-risk HFpEF phenotype.Tirzepatide additionally reduced hard CV outcomes,providing proof of concept that targeting obesity can favorably alter HFpEF disease course.展开更多
The Xisha Islands accumulated significant amounts of phosphorus(P)due to seabird guano input.However,the seabird population has declined significantly in recent years as a result of climate change and human activities...The Xisha Islands accumulated significant amounts of phosphorus(P)due to seabird guano input.However,the seabird population has declined significantly in recent years as a result of climate change and human activities.As plant communities develop,significant amounts of organic matter and nitrogen were introduced into the soil through plant humus.To investigate the effects of different sources on the distribution of phosphorus fractions during the past~1000 years of ecological evolution,we conducted k-edge x-ray absorption near-edge structural spectroscopy(XANES),sequential extraction,and31P nuclear magnetic resonance(31P-NMR)of soil phosphorus in two ornithogenic soil profiles from the Xisha Islands.Combining these methods,the results revealed that magnesium-bound phosphorus(Mg-P)in modern guano underwent mineralization after deposition,and its content decreased by>50%.Subsequently,it may be released and combine with the abundant calcium-bearing minerals to transform into calcium-bound phosphorus(Ca-P).The results of XANES and sequential extraction indicated that Ca-P dominated the soil phosphorus pool by up to 70%–90%.The distributions of total organic carbon,total nitrogen,and total phosphorus in the soil profile are consistent with the evolutionary characteristics of nutrient supply from guano or plant humus during historical periods.In addition,although plant humus has lower total phosphorus content than guano,it may be an important source of organic phosphorus for topsoil.This study provides insights into the evolution of coral island ecosystems by examining phosphorus fractions and sources of phosphorus and offers valuable references for understanding nutrient cycling on tropical coral islands.展开更多
Lithium(Li)is an‘emerging'environmental pollutant,especially in soil,which is a great concern because it can endanger human health through the food chain.Compared with traditional chemical analyses,hyperspectral ...Lithium(Li)is an‘emerging'environmental pollutant,especially in soil,which is a great concern because it can endanger human health through the food chain.Compared with traditional chemical analyses,hyperspectral techniques have achieved many exciting results in soil metal monitoring due to their advantages of being fast and non-destructive.However,insufficient attention has been paid to lithium in soil,and the feasibility of its estimation using hyperspectral techniques needs to be investigated.We studied 97 soil samples from claytype lithium mines in the Ertanggou area of the East Tianshan Mountains of Xinjiang to explore the effects of spectral resolution,fractional order derivatives(FOD),and characteristic band selection on the estimation accuracy of clay Li content,to obtain a fast and effective method for estimating clay Li content.Finally,we developed a new method for rapid and nondestructive estimation of soil lithium content.We have obtained some important results from the study.Spectral resolution exerts a significant impact on model performance,and its reduction usually leads to a decline in model performance.For the full band,the models constructed with low-order derivatives were superior to those with high-order derivatives,and the best model was obtained at the 0.4-order derivative(coefficient of determination(R2)and relative predictive deviation(RPD)of 0.777 and 2.118,respectively).In the characteristic bands,the lower order is sensitive to the visible-near-infrared range,and the higher order is sensitive to the short-wave infrared range,and the model constructed with the higher-order derivatives outperforms the lower-order derivatives.In this study,the combination of FOD and Random Forest(RF)can significantly improve the model performance,with R2,Relative Root Mean Squared Error(RRMSE),and RPD being 0.849,1.526,and 2.574,respectively.Therefore,this research provides a theoretical basis and technical reference for imaging hyperspectral exploration of anomalous areas of clay-type Li resources.展开更多
Nitrogen is essential for plant growth,however,excessive application leads to environmental pollution and increased production costs.Improving nitrogen use efficiency(NUE)is therefore critical for sustainable agricult...Nitrogen is essential for plant growth,however,excessive application leads to environmental pollution and increased production costs.Improving nitrogen use efficiency(NUE)is therefore critical for sustainable agriculture.This study aimed to elucidate how N fractions and functional allocations jointly regulate N accumulation and biomass production in flue-cured tobacco,with a focus on understanding physiological mechanisms underlying cultivar differences.Two contrasting tobacco cultivars,Hongda(higher NUE)and K326(lower NUE),were grown under three N application levels:0 g N per plant(CK),4 g N per plant(T1)and 8 g N per plant(T2).Biomass and N accumulation were monitored across multiple growth stages.N was divided into four solubility fractions:water-soluble(Nw),sodium dodecyl sulfate(SDS)-soluble(Ns),SDS-insoluble(Nin-SDS)and non-protein N.These were then further divided into four functional categories:photosynthetic(Npsn),respiratory(Nresp),structural and storage N.Stepwise regression analysis was used to identify key N components influencing growth.Under N-deficient conditions(CK),greater allocation to Npsn and Nresp supported continued growth.Under moderate N input(T1),increased stem Nin-SDS contributed to leaf biomass accumulation.At high N input(T2),elevated root Nw enhanced total biomass,reducing genotypic differences.N partitioning into distinct functional forms played a central role in regulating biomass production and overall NUE.The superior NUE of tobacco cv.Hongda was associated with its effective N allocation toward physiologically active pools and organs.These findings provide a physiological basis for optimizing N management and breeding tobacco cultivars with reduced fertilizer requirements.展开更多
Cloud fraction and its diurnal cycle in Qinghai-Xizang Plateau are critical for understanding the variation of radiative budget regionally and globally.Satellite remote sensing is an important tool to develop long-ter...Cloud fraction and its diurnal cycle in Qinghai-Xizang Plateau are critical for understanding the variation of radiative budget regionally and globally.Satellite remote sensing is an important tool to develop long-term cloud datasets for climate research.However,the daily cloud records built from polar-orbiting sensors,e.g.,MODIS,lack consideration of cloud diurnal cycle.This study assesses the uncertainties regarding the absence of diurnal cycles,and further develops a daily cloud fraction algorithm for MODIS to reduce such uncertainty.It is found that the deep learning model can take inputs directly from MODIS infrared bands’brightness temperature and project the daily cloud fraction that include consideration of cloud diurnal cycles.The evaluation indicates that the uncertainties of the new product with respect to its limited observing frequencies have been reduced 8%∼20%.This study sheds light on a simple yet effective way to mitigate the diurnal-cycle-induced-uncertainties in generating other polar-orbiting sensors’cloud properties.展开更多
Background:Poor neurological recovery after in-hospital cardiac arrest(IHCA)may be exacerbated by postresuscitation myocardial dysfunction.However,the predictive value of left ventricular ejection fraction(LVEF)for ne...Background:Poor neurological recovery after in-hospital cardiac arrest(IHCA)may be exacerbated by postresuscitation myocardial dysfunction.However,the predictive value of left ventricular ejection fraction(LVEF)for neurological outcomes remains insufficiently explored.Methods:This retrospective study included patients with IHCA who achieved return of spontaneous circulation at the Zigong Fourth People's Hospital between 2019 and 2024.Neurological function at discharge was evaluated using the cerebral performance category(CPC)score(favorable:CPC≤2;unfavorable:CPC>2).Multivariable logistic regression,restricted cubic splines,and receiver operating characteristic curves were used to evaluate the predictive performance.The incremental value of LVEF was assessed using net reclassification improvement and integrated discrimination improvement.Decision and calibration curves were used to assess clinical utility.Results:Of the 179 patients,31(17.3%)exhibited favorable neurological outcomes.After adjusting for mechanical ventilation and consciousness levels,LVEF remained an independent predictor of favorable recovery(odds ratio:1.057;95%confidence interval[CI]:1.005-1.112;P=0.032).Restricted cubic splines analysis demonstrated a linear dose-response relation between LVEF and favorable outcomes(P for nonlinearity=0.984).The integrated model incorporating LVEF,cardiac arrest survival postresuscitation in-hospital,and modified early warning score yielded an area under the curve of 0.869(95%Cl:0.803-0.935).Bootstrap analysis identified an optimal LVEF threshold of 58%(95%Cl:55%-65%).The addition of LVEF to conventional scoring systems improved both the net reclassification improvement and integrated discrimination improvement(P<0.05),with the decision curve analysis confirming an enhanced net clinical benefit.Calibration curves showed good agreement between the predicted and observed outcomes.Conclusion:Bedside ultrasonographic assessment of LVEF is an independent linear predictor of neurological recovery in patients with IHCA.Incorporating LVEF into existing clinical frameworks(cardiac arrest survival postresuscitation in-hospital and modified early warning score)enhances the prognostic accuracy and risk stratification,providing objective evidence for early clinical decisionmaking.展开更多
This paper focuses on the stability of the 3D anisotropic incompressible magnetohydrodynamic(MHD)system with partial and fractional dissipation near a background magnetic field.We obtain the global well-posedness of t...This paper focuses on the stability of the 3D anisotropic incompressible magnetohydrodynamic(MHD)system with partial and fractional dissipation near a background magnetic field.We obtain the global well-posedness of the solutions,provided that the H2(R3)norm of initial datum is sufficiently small.Due to the emergence of fractional dissipation,some conventional energy estimate methods are no longer applicable.To overcome this challenge,we establish new fractional anisotropic inequalities,which play a crucial role in bounding the nonlinear terms by the dissipative parts.Our result extends some existing conclusions.展开更多
The fractional quantum Hall effect remains a captivating area in condensed matter physics,characterized by strongly correlated topological order,which manifests as fractionalized excitations and anyonic statistics.Num...The fractional quantum Hall effect remains a captivating area in condensed matter physics,characterized by strongly correlated topological order,which manifests as fractionalized excitations and anyonic statistics.Numerical simulations,such as exact diagonalization,density matrix renormalization groups,matrix product states,and Monte Carlo methods are essential for examining the properties of strongly correlated systems.Recently,density functional theory has been employed in this field within the framework of composite fermion theory.This paper systematically evaluates how density functional theory approaches have addressed fundamental challenges in fractional quantum Hall systems,including ground state and low-energy excitations.Special attention is given to the insights provided by density functional theory regarding composite fermion behavior,edge effects,and the nature of fractional charge and magnetoroton excitations.The discussion critically examines both the advantages and limitations of these approaches,while highlighting the productive interplay between numerical simulations and theoretical models.Future directions are explored,particularly the promising potential of time-dependent density functional theory for modeling non-equilibrium dynamics in quantum Hall systems.展开更多
This paper investigates numerical solutions for stochastic fractional differential equations driven by fractional Brownian motion.We develop an approximation scheme for the fractional noise term and establish a corres...This paper investigates numerical solutions for stochastic fractional differential equations driven by fractional Brownian motion.We develop an approximation scheme for the fractional noise term and establish a corresponding numerical method.The theoretical analysis includes proving the stability of the numerical solution and its convergence to the exact solution.Numerical experiments implement the Jacobi method to simulate a conformable stochastic differential equation,demonstrating the method's performance through solution behavior and error distribution analysis.展开更多
Petroleum leakage is a major groundwater contamination source,with chemical composition of water soluble fractions(WSFs)from diverse oil sources significantly impacting groundwater quality and source identification.Th...Petroleum leakage is a major groundwater contamination source,with chemical composition of water soluble fractions(WSFs)from diverse oil sources significantly impacting groundwater quality and source identification.The aim of this study was to assess impact of 15 diverse oils on groundwater quality and environmental forensics based on oil-water equilibrium experiments.Our results indicate that contamination of groundwater by gasoline and naphtha is primarily attributed to volatile hydrocarbons,while pollution from diesel,kerosene,and crude oil is predominantly from non-hydrocarbons.Rapid determination of the extent of non-hydrocarbon pollution in WSFs was achieved through a new quantitative index.Gasoline and naphtha exhibited the highest groundwater contamination potential while kerosene and light crude oils were also likely to cause groundwater contamina-tion.Although volatile hydrocarbons in the WSFs of diesel and jet fuel do not easily exceed current regulatory standards,unregulated non-hydrocarbons may pose a more severe contamination risk to groundwater.Notably,the presence of significant benzene and toluene,hydrogenation and alkylation products(e.g.,C4-C5 alkylben-zenes,alkylindenes,alkyltetralins,and dihydro-indenes),cycloalkanes in WSFs can effectively be utilized for preliminary source identification of light distillates,middle distillates,and crude oils,respectively.展开更多
BACKGROUND Obesity-related heart failure in patients is often associated with a high symptom burden.However,no treatments have been proven to specifically target obesity-related heart failure with preserved ejection f...BACKGROUND Obesity-related heart failure in patients is often associated with a high symptom burden.However,no treatments have been proven to specifically target obesity-related heart failure with preserved ejection fraction(HFpEF).AIM To evaluate the efficacy of semaglutide in patients with obesity and HFpEF.METHODS Per the PRISMA guidelines,studies reporting clinical outcomes of semaglutide in patients with obesity and HFpEF were included.The outcomes included percentage weight change and adjudicated heart failure events.Both random and common effects models were used for the data analysis.The random intercept logistic regression model was used to compute the proportions,and the Peto method was used to compute the odds ratios(OR).A P≤0.05 was considered significant.RESULTS In total,three studies with 1463 patients with obesity and HFpEF were included in the study.The mean age of the patients was 68.8±3.47 years.50.7%of the patients were females.Patients who received semaglutide had statistically higher odds of achieving 10%(OR=6.35;95%CI:1.54-26.21;P<0.00001)and 15%(OR=9.44;95%CI:2.91-30.60;P<0.0001)weight reductions compared to those who received placebo.Additionally,patients who received semaglutide had lower odds of adjudicated heart failure event(OR=0.29;95%CI:0.14-0.58;P=0.0005)when compared to patients on placebo.CONCLUSION Our study demonstrates that semaglutide is significantly effective in reducing weight and potentially lowering the risk of heart failure events.This suggests that semaglutide could be a promising therapeutic option for managing obesity-related HFpEF.展开更多
This paper establishes the boundedness of fractional integral operators associated with Schrödinger operators and their commutators with BMOθ(ρ)functions on generalized fractional mixed Morrey spaces.This is...This paper establishes the boundedness of fractional integral operators associated with Schrödinger operators and their commutators with BMOθ(ρ)functions on generalized fractional mixed Morrey spaces.This is achieved by employing function decomposition and stratification techniques in these spaces,while drawing on known boundedness results in the context of mixed Lebesgue spaces.展开更多
Excess barium(Ba)in soil can result in Ba overenrichment in crops,which may adversely affect human health.However,the transport and isotopic fractionation of Ba in plants remain poorly understood.We analyzed the Ba co...Excess barium(Ba)in soil can result in Ba overenrichment in crops,which may adversely affect human health.However,the transport and isotopic fractionation of Ba in plants remain poorly understood.We analyzed the Ba content and isotopic composition of three crops(rice,pak choi,and maize)grown in Ba-contaminated soil.Results for rice and maize demonstrated significant fractionation and environmental sensitivity in the transport of Ba,and longer flooding durations were found to increase Ba accumulation in rice grains during the filling stage.In contrast,research on pak choi revealed limited fractionation and strong uptake and transport of Ba.The estimated daily intake of Ba in the edible portion of pak choi(stems and leaves)was 15-24times the recommended daily intake of 0.2 mg/kg body weight per day.Therefore,pak choi was the least suitable crop for Ba-contaminated areas.This study provides new insights into how Ba isotopic fractionation can trace Ba transport in crops,offering practical applications for food safety and environmental monitoring.展开更多
Lime application represents an established approach for ameliorating soil acidity,and understanding its effects on the interactions between aluminum(Al)and iron(Fe)oxides and soil organic carbon(SOC)fractions is essen...Lime application represents an established approach for ameliorating soil acidity,and understanding its effects on the interactions between aluminum(Al)and iron(Fe)oxides and soil organic carbon(SOC)fractions is essential for promoting sustainable agricultural practices that enhance carbon sequestration.This investigation examined the interactions among Al and Fe oxides and SOC fractions under long-term fertilization and liming.A long-term field experiment was implemented with five treatments:CK(no fertilizer),N(nitrogen fertilizer),NCa(N plus lime),NPK(nitrogen,phosphorus,and potassium fertilizer),and NPKCa(NPK plus lime).Soil samples were obtained from three depths:0-10,10-20,and 20-30 cm.The findings revealed that lime application increased SOC by 20.84%under the N treatment but decreased SOC by 9.97%under NPK.At the 0-10 cm depth,dissolved organic carbon(DOC)was substantially higher under NCa(410.51 mg kg-1)and NPKCa(372.83 mg kg-1)compared with CK.Particulate organic carbon(POC)and mineral-associated organic carbon(MAOC)demonstrated consistent enhancement under NPK and NPKCa across all soil depths compared with CK.DOC exhibited significant positive correlations with both aluminum(Ald),reactive aluminum(Alo)and aluminum(Alp),indicating a key role of organically bound and reactive Al in carbon dynamics.Compared to the CK treatment,SOC stock increased significantly by 43.49%under NPK and by 36.82%under NPKCa.Structural equation modeling demonstrated that lime application mitigated the negative effects of free Al(Ald)on carbon sequestration,while Fe oxides(Fed)contributed positively to SOC stabilization.DOC showed no significant impact on carbon sequestration rate(CSR),while easily oxidizable carbon(EOC)negatively affected CSR directly.These results highlight the crucial role of lime in improving acidic soil conditions and enhancing the stability and sequestration of soil organic carbon.展开更多
Fractional discrete systems can enable the modeling and control of the complicated processes more adaptable through the concept of versatility by providing systemdynamics’descriptions withmore degrees of freedom.Nume...Fractional discrete systems can enable the modeling and control of the complicated processes more adaptable through the concept of versatility by providing systemdynamics’descriptions withmore degrees of freedom.Numerical approaches have become necessary and sufficient to be addressed and employed for benefiting from the adaptability of such systems for varied applications.A variety of fractional Layla and Majnun model(LMM)system kinds has been proposed in the current work where some of these systems’key behaviors are addressed.In addition,the necessary and sufficient conditions for the stability and asymptotic stability of the fractional dynamic systems are investigated,as a result of which,the necessary requirements of the LMM to achieve constant and asymptotically steady zero resolutions are provided.As a special case,when Layla and Majnun have equal feelings,we propose an analysis of the system in view of its equilibrium and fixed point sets.Considering that the system has marginal stability if its eigenvalues have both negative and zero real portions,it is demonstrated that the system neither converges nor diverges to a steady trajectory or equilibrium point.It,rather,continues to hover along the line separating stability and instability based on the fractional LMM system.展开更多
摘要Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification.
基金supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University(IMSIU)(grant number IMSIU-DDRSP2601).
摘要This paper introduces a novel fractional-order model based on the Caputo-Fabrizio(CF)derivative for analyzing computer virus propagation in networked environments.The model partitions the computer population into four compartments:susceptible,latently infected,breaking-out,and antivirus-capable systems.By employing the CF derivative—which uses a nonsingular exponential kernel—the framework effectively captures memory-dependent and nonlocal characteristics intrinsic to cyber systems,aspects inadequately represented by traditional integer-order models.Under Lipschitz continuity and boundedness assumptions,the existence and uniqueness of solutions are rigorously established via fixed-point theory.We develop a tailored two-step Adams-Bashforth numerical scheme for the CF framework and prove its second-order accuracy.Extensive numerical simulations across various fractional orders reveal that memory effects significantly influence virus transmission and control dynamics;smaller fractional orders produce more pronounced memory effects,delaying both infection spread and antivirus activation.Further theoretical analysis,including Hyers-Ulam stability and sensitivity assessments,reinforces the model’s robustness and identifies key parameters governing virus dynamics.The study also extends the framework to incorporate stochastic effects through a stochastic CF formulation.These results underscore fractional-order modeling as a powerful analytical tool for developing robust and effective cybersecurity strategies.
基金financially supported by the National Natural Science Foundation of China(42477044,32171648 and U23A2017)the Hubei Provincial Science and Technology Program,China(2025AFD451 and 2022CFB030)。
摘要Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In this study,the effect of land use type on carbon storage and fractionation was quantified based on organic carbon and its13C abundance at the microscale of soil aggregates and density fractions in Tibetan alpine ecosystems.The sequence of soil aggregate destruction in the land use types of plantation(13.1%)<shrubland(32.7%)<grassland(47.9%)<farmland(61.8%)shows that plantations strengthen the soil structure.Plantation land had a greater contribution of light fraction organic carbon(28.3%)but a lower contribution of mineral-associated organic carbon(40.6%)to the carbon stock compared to farmland(13.5 and 70.3%).Interestingly,plantation land enhanced the aggregational differentiation of organic carbon and13C in each density fraction,whereas no such phenomenon existed in the soil organic carbon.Carbon isotope analyses revealed that carbon transfer in the plantation land occurred from the light fraction in macroaggregates(–24.9‰)to the mineral-associated fraction in microaggregates(–19.9‰).When compared to the other three land use types,the low transferability of carbon in aggregates and density fractions in plantation land provides a stable carbon pool for the Tibetan Plateau.This study shows that plantations can mitigate global climate change by slowing carbon transfer and increasing carbon storage at the microscale of aggregates and density fractions in alpine regions.
摘要In this paper,the new solitary wave solutions of the fractional doubly dispersive equation(FDDE)are investigated.These solutions are used in demonstrating wave transmission in elastic inhomogeneous Murnaghan’s rod.A very effective method,known as the unified method,is used here to obtain these solutions.In different conditions,the obtained solutions exhibit different pulse patterns including bright,periodic,combined bright-dark,two-soliton interaction,three-soliton interaction,five-soliton interaction,w-shaped,m-shaped,and u-shaped solutions.These physical characteristics are thoroughly investigated by the graphical representation under different values of the parameters which shows the reliability and productivity of the proposed method.In addition,linear stability analysis is applied to analyse the stability of the considered model.The novel aspect of this study is that the investigated model has never been studied by using the proposed method,and the resulting solutions have never been accomplished previously.
摘要Interpretation of coronary physiology with fractional flow reserve(FFR)assumes stable relationships between flow,demand,and resistance,but conduction abnormalities such as left bundle branch block(LBBB)can disrupt myocardial activation,perfusion,and pressure-derived ischemic indices especially in aged patients.[1]Heart rate related LBBB is a transient,rate-dependent conduction delay that induces ventricular dyssynchrony and impairs regional perfusion,potentially altering instantaneous FFR(iFFR)accuracy,particularly in the left anterior descending artery or the left circumflex artery disease.[2]Because the physiological impact of heart rate related LBBB is unknown,we investigated its influence on iFFR in aged patients with intermediate stenoses in the left coronary artery.
摘要BACKGROUND Obesity-related heart failure with preserved ejection fraction(HFpEF)is highly prevalent,symptomatically disabling,and lacks clearly disease-modifying pharmacotherapy.Glucagon-like peptide(GLP)-1-based incretin agonists-including GLP-1 receptor agonists(GLP-1 RAs;e.g.,semaglutide)and the dual GIP/GLP-1 RA tirzepatide-induce substantial weight loss and favorable cardiometabolic effects and have recently been evaluated in obese HFpEF populations.AIM To systematically evaluate the efficacy and safety of GLP-1–based incretin agonists(including GLP-1 RAs and the dual GIP/GLP-1 RA tirzepatide)in patients with obesity-related HFpEF and to quantify their effects through meta-analysis.METHODS PubMed/MEDLINE,EMBASE,Cochrane CENTRAL,and Web of Science were searched from inception to October 2025 for randomized controlled trials(RCT)evaluating GLP-1–based incretin agonist therapy in adults with HFpEF and obesity.Outcomes included health status[Kansas City Cardiomyopathy Questionnaire clinical summary score(KCCQ-CSS)],body weight,exercise capacity,heart failure events,and safety.Risk of bias was assessed using the Cochrane Risk of Bias 2 tool.Random-effects meta-analyses were performed for KCCQ-CSS and percentage body weight change.RESULTS Three RCTs(n=1876)were included in quantitative synthesis:STEP-HFpEF(n=529),STEP-HFpEF DM(n=616),and SUMMIT(n=731).GLP-1-based incretin agonist therapy significantly improved health status,with a pooled increase in KCCQ-CSS of+7.33 points[95%confidence interval(CI):5.84 to 8.82;I²=0%].Substantial weight loss was observed,with a pooled reduction of-9.56 percentage points(95%CI:-12.15 to-6.97;I²=58%).Tirzepatide significantly reduced the composite of cardiovascular(CV)death or worsening heart failure event(hazard ratio 0.62,95%CI:0.41-0.95;P=0.026),while semaglutide trials demonstrated consistent favorable trends.Across trials,GLP-1-based therapies improved exercise capacity and were associated with fewer serious adverse events,with gastrointestinal symptoms being the most common side effect.CONCLUSION GLP-1-based incretin agonists produce clinically meaningful improvements in symptoms,functional capacity,and body weight in patients with obesity-related HFpEF,with consistent benefit across trials and acceptable safety.Meta-analysis confirms robust improvement in health status and substantial weight reduction,supporting this therapeutic class as a promising disease-modifying strategy for this high-risk HFpEF phenotype.Tirzepatide additionally reduced hard CV outcomes,providing proof of concept that targeting obesity can favorably alter HFpEF disease course.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(grant no.XDB40000000)the National Natural Science Foundation of China(grant nos.42276240,41976191,and 42373007)。
摘要The Xisha Islands accumulated significant amounts of phosphorus(P)due to seabird guano input.However,the seabird population has declined significantly in recent years as a result of climate change and human activities.As plant communities develop,significant amounts of organic matter and nitrogen were introduced into the soil through plant humus.To investigate the effects of different sources on the distribution of phosphorus fractions during the past~1000 years of ecological evolution,we conducted k-edge x-ray absorption near-edge structural spectroscopy(XANES),sequential extraction,and31P nuclear magnetic resonance(31P-NMR)of soil phosphorus in two ornithogenic soil profiles from the Xisha Islands.Combining these methods,the results revealed that magnesium-bound phosphorus(Mg-P)in modern guano underwent mineralization after deposition,and its content decreased by>50%.Subsequently,it may be released and combine with the abundant calcium-bearing minerals to transform into calcium-bound phosphorus(Ca-P).The results of XANES and sequential extraction indicated that Ca-P dominated the soil phosphorus pool by up to 70%–90%.The distributions of total organic carbon,total nitrogen,and total phosphorus in the soil profile are consistent with the evolutionary characteristics of nutrient supply from guano or plant humus during historical periods.In addition,although plant humus has lower total phosphorus content than guano,it may be an important source of organic phosphorus for topsoil.This study provides insights into the evolution of coral island ecosystems by examining phosphorus fractions and sources of phosphorus and offers valuable references for understanding nutrient cycling on tropical coral islands.
基金Sponsored the National Natural Science Foundation of China(42502088)the National Major Science and Technology Project of China(2025ZD1007504-1)+2 种基金the Special Research Fund of Natural Science(Special Post)of Guizhou University(X202402)the Guizhou Provincial Science and Technology Projects(QKHJC[2024]youth 153)the Xinjiang Uygur Autonomous Region Natural Science Foundation(2024D01A147)。
摘要Lithium(Li)is an‘emerging'environmental pollutant,especially in soil,which is a great concern because it can endanger human health through the food chain.Compared with traditional chemical analyses,hyperspectral techniques have achieved many exciting results in soil metal monitoring due to their advantages of being fast and non-destructive.However,insufficient attention has been paid to lithium in soil,and the feasibility of its estimation using hyperspectral techniques needs to be investigated.We studied 97 soil samples from claytype lithium mines in the Ertanggou area of the East Tianshan Mountains of Xinjiang to explore the effects of spectral resolution,fractional order derivatives(FOD),and characteristic band selection on the estimation accuracy of clay Li content,to obtain a fast and effective method for estimating clay Li content.Finally,we developed a new method for rapid and nondestructive estimation of soil lithium content.We have obtained some important results from the study.Spectral resolution exerts a significant impact on model performance,and its reduction usually leads to a decline in model performance.For the full band,the models constructed with low-order derivatives were superior to those with high-order derivatives,and the best model was obtained at the 0.4-order derivative(coefficient of determination(R2)and relative predictive deviation(RPD)of 0.777 and 2.118,respectively).In the characteristic bands,the lower order is sensitive to the visible-near-infrared range,and the higher order is sensitive to the short-wave infrared range,and the model constructed with the higher-order derivatives outperforms the lower-order derivatives.In this study,the combination of FOD and Random Forest(RF)can significantly improve the model performance,with R2,Relative Root Mean Squared Error(RRMSE),and RPD being 0.849,1.526,and 2.574,respectively.Therefore,this research provides a theoretical basis and technical reference for imaging hyperspectral exploration of anomalous areas of clay-type Li resources.
基金supported by the Key Research and Development Program of Yunnan,China(202202AE090034)Basic Research Special Project of the Yunnan Provincial Department of Science and Technology,China(202401AU070082 and 202401BD070001-049).
摘要Nitrogen is essential for plant growth,however,excessive application leads to environmental pollution and increased production costs.Improving nitrogen use efficiency(NUE)is therefore critical for sustainable agriculture.This study aimed to elucidate how N fractions and functional allocations jointly regulate N accumulation and biomass production in flue-cured tobacco,with a focus on understanding physiological mechanisms underlying cultivar differences.Two contrasting tobacco cultivars,Hongda(higher NUE)and K326(lower NUE),were grown under three N application levels:0 g N per plant(CK),4 g N per plant(T1)and 8 g N per plant(T2).Biomass and N accumulation were monitored across multiple growth stages.N was divided into four solubility fractions:water-soluble(Nw),sodium dodecyl sulfate(SDS)-soluble(Ns),SDS-insoluble(Nin-SDS)and non-protein N.These were then further divided into four functional categories:photosynthetic(Npsn),respiratory(Nresp),structural and storage N.Stepwise regression analysis was used to identify key N components influencing growth.Under N-deficient conditions(CK),greater allocation to Npsn and Nresp supported continued growth.Under moderate N input(T1),increased stem Nin-SDS contributed to leaf biomass accumulation.At high N input(T2),elevated root Nw enhanced total biomass,reducing genotypic differences.N partitioning into distinct functional forms played a central role in regulating biomass production and overall NUE.The superior NUE of tobacco cv.Hongda was associated with its effective N allocation toward physiologically active pools and organs.These findings provide a physiological basis for optimizing N management and breeding tobacco cultivars with reduced fertilizer requirements.
基金National Natural Science Foundation Young Scientists Fund(Type B)(No.42522507)National Key Research and Development Program of China(No.2023YFB3905900)+2 种基金Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2021122)National Natural Science Foundation of China General Program(No.42175152)National Natural Science Foundation of China(No.42405145).
摘要Cloud fraction and its diurnal cycle in Qinghai-Xizang Plateau are critical for understanding the variation of radiative budget regionally and globally.Satellite remote sensing is an important tool to develop long-term cloud datasets for climate research.However,the daily cloud records built from polar-orbiting sensors,e.g.,MODIS,lack consideration of cloud diurnal cycle.This study assesses the uncertainties regarding the absence of diurnal cycles,and further develops a daily cloud fraction algorithm for MODIS to reduce such uncertainty.It is found that the deep learning model can take inputs directly from MODIS infrared bands’brightness temperature and project the daily cloud fraction that include consideration of cloud diurnal cycles.The evaluation indicates that the uncertainties of the new product with respect to its limited observing frequencies have been reduced 8%∼20%.This study sheds light on a simple yet effective way to mitigate the diurnal-cycle-induced-uncertainties in generating other polar-orbiting sensors’cloud properties.
基金supported by the Sichuan Science and Technology Program(2024JDKP0021)the Open Foundation of Artificial Intelligence Key Laboratory of Sichuan Province(2020RYY03)+2 种基金the Health Commission of Zigong High-Level Talent Development Project(WJW-GCCRC024)the Sichuan Medical Association Scientific Research Project(S22083)the Research Project of Zigong City Science and Technology and Intellectual Property Right Bureau(2023-YGY-3-04)。
摘要Background:Poor neurological recovery after in-hospital cardiac arrest(IHCA)may be exacerbated by postresuscitation myocardial dysfunction.However,the predictive value of left ventricular ejection fraction(LVEF)for neurological outcomes remains insufficiently explored.Methods:This retrospective study included patients with IHCA who achieved return of spontaneous circulation at the Zigong Fourth People's Hospital between 2019 and 2024.Neurological function at discharge was evaluated using the cerebral performance category(CPC)score(favorable:CPC≤2;unfavorable:CPC>2).Multivariable logistic regression,restricted cubic splines,and receiver operating characteristic curves were used to evaluate the predictive performance.The incremental value of LVEF was assessed using net reclassification improvement and integrated discrimination improvement.Decision and calibration curves were used to assess clinical utility.Results:Of the 179 patients,31(17.3%)exhibited favorable neurological outcomes.After adjusting for mechanical ventilation and consciousness levels,LVEF remained an independent predictor of favorable recovery(odds ratio:1.057;95%confidence interval[CI]:1.005-1.112;P=0.032).Restricted cubic splines analysis demonstrated a linear dose-response relation between LVEF and favorable outcomes(P for nonlinearity=0.984).The integrated model incorporating LVEF,cardiac arrest survival postresuscitation in-hospital,and modified early warning score yielded an area under the curve of 0.869(95%Cl:0.803-0.935).Bootstrap analysis identified an optimal LVEF threshold of 58%(95%Cl:55%-65%).The addition of LVEF to conventional scoring systems improved both the net reclassification improvement and integrated discrimination improvement(P<0.05),with the decision curve analysis confirming an enhanced net clinical benefit.Calibration curves showed good agreement between the predicted and observed outcomes.Conclusion:Bedside ultrasonographic assessment of LVEF is an independent linear predictor of neurological recovery in patients with IHCA.Incorporating LVEF into existing clinical frameworks(cardiac arrest survival postresuscitation in-hospital and modified early warning score)enhances the prognostic accuracy and risk stratification,providing objective evidence for early clinical decisionmaking.
摘要This paper focuses on the stability of the 3D anisotropic incompressible magnetohydrodynamic(MHD)system with partial and fractional dissipation near a background magnetic field.We obtain the global well-posedness of the solutions,provided that the H2(R3)norm of initial datum is sufficiently small.Due to the emergence of fractional dissipation,some conventional energy estimate methods are no longer applicable.To overcome this challenge,we establish new fractional anisotropic inequalities,which play a crucial role in bounding the nonlinear terms by the dissipative parts.Our result extends some existing conclusions.
基金supported by National Natural Science Foundation of China under Grant Nos.12474140 and 12347101supported by National Natural Science Foundation of China under Grant No.12204432+1 种基金supported by the graduate research and innovation foundation of Chongqing,China under Grant No.CYB25066the inaugural Doctoral Student Special Project of the China Association for Science and Technology Young Talents Lifting Program(2024)。
摘要The fractional quantum Hall effect remains a captivating area in condensed matter physics,characterized by strongly correlated topological order,which manifests as fractionalized excitations and anyonic statistics.Numerical simulations,such as exact diagonalization,density matrix renormalization groups,matrix product states,and Monte Carlo methods are essential for examining the properties of strongly correlated systems.Recently,density functional theory has been employed in this field within the framework of composite fermion theory.This paper systematically evaluates how density functional theory approaches have addressed fundamental challenges in fractional quantum Hall systems,including ground state and low-energy excitations.Special attention is given to the insights provided by density functional theory regarding composite fermion behavior,edge effects,and the nature of fractional charge and magnetoroton excitations.The discussion critically examines both the advantages and limitations of these approaches,while highlighting the productive interplay between numerical simulations and theoretical models.Future directions are explored,particularly the promising potential of time-dependent density functional theory for modeling non-equilibrium dynamics in quantum Hall systems.
基金Supported by the National Natural Science Foundation of China(11971101,12171081)Natural Science Foundation of Shanghai(24ZR1402900)the Fundamental Research Funds for the Central Universities(CUSF-DH-D-2025033)。
摘要This paper investigates numerical solutions for stochastic fractional differential equations driven by fractional Brownian motion.We develop an approximation scheme for the fractional noise term and establish a corresponding numerical method.The theoretical analysis includes proving the stability of the numerical solution and its convergence to the exact solution.Numerical experiments implement the Jacobi method to simulate a conformable stochastic differential equation,demonstrating the method's performance through solution behavior and error distribution analysis.
基金supported by the National Science Foundation of China(Nos.42177042,and 42477051)the National Key R&D Program of China(No.2023YFC3708700)the Science Foundation of China University of Petroleum-Beijing(No.2462022QNXZ006).
摘要Petroleum leakage is a major groundwater contamination source,with chemical composition of water soluble fractions(WSFs)from diverse oil sources significantly impacting groundwater quality and source identification.The aim of this study was to assess impact of 15 diverse oils on groundwater quality and environmental forensics based on oil-water equilibrium experiments.Our results indicate that contamination of groundwater by gasoline and naphtha is primarily attributed to volatile hydrocarbons,while pollution from diesel,kerosene,and crude oil is predominantly from non-hydrocarbons.Rapid determination of the extent of non-hydrocarbon pollution in WSFs was achieved through a new quantitative index.Gasoline and naphtha exhibited the highest groundwater contamination potential while kerosene and light crude oils were also likely to cause groundwater contamina-tion.Although volatile hydrocarbons in the WSFs of diesel and jet fuel do not easily exceed current regulatory standards,unregulated non-hydrocarbons may pose a more severe contamination risk to groundwater.Notably,the presence of significant benzene and toluene,hydrogenation and alkylation products(e.g.,C4-C5 alkylben-zenes,alkylindenes,alkyltetralins,and dihydro-indenes),cycloalkanes in WSFs can effectively be utilized for preliminary source identification of light distillates,middle distillates,and crude oils,respectively.
摘要BACKGROUND Obesity-related heart failure in patients is often associated with a high symptom burden.However,no treatments have been proven to specifically target obesity-related heart failure with preserved ejection fraction(HFpEF).AIM To evaluate the efficacy of semaglutide in patients with obesity and HFpEF.METHODS Per the PRISMA guidelines,studies reporting clinical outcomes of semaglutide in patients with obesity and HFpEF were included.The outcomes included percentage weight change and adjudicated heart failure events.Both random and common effects models were used for the data analysis.The random intercept logistic regression model was used to compute the proportions,and the Peto method was used to compute the odds ratios(OR).A P≤0.05 was considered significant.RESULTS In total,three studies with 1463 patients with obesity and HFpEF were included in the study.The mean age of the patients was 68.8±3.47 years.50.7%of the patients were females.Patients who received semaglutide had statistically higher odds of achieving 10%(OR=6.35;95%CI:1.54-26.21;P<0.00001)and 15%(OR=9.44;95%CI:2.91-30.60;P<0.0001)weight reductions compared to those who received placebo.Additionally,patients who received semaglutide had lower odds of adjudicated heart failure event(OR=0.29;95%CI:0.14-0.58;P=0.0005)when compared to patients on placebo.CONCLUSION Our study demonstrates that semaglutide is significantly effective in reducing weight and potentially lowering the risk of heart failure events.This suggests that semaglutide could be a promising therapeutic option for managing obesity-related HFpEF.
基金supported by National Natural Science Foundation of China(Grant No.12361018)Key Laboratory of Computational Science and Application of Hainan Province(Grant No.JSKX202304)Gansu Province Outstanding Youth Fund project(Grant No.24JRRA121).
摘要This paper establishes the boundedness of fractional integral operators associated with Schrödinger operators and their commutators with BMOθ(ρ)functions on generalized fractional mixed Morrey spaces.This is achieved by employing function decomposition and stratification techniques in these spaces,while drawing on known boundedness results in the context of mixed Lebesgue spaces.
基金financially supported by the National Natural Science Foundation of China (No.42203014,and 42107104)Guizhou Provincial Basie Research Program (Natural Science)(MS [2025]205)the Research Fund of Guizhou Minzu University (GZMUZK[2024]QD60)
摘要Excess barium(Ba)in soil can result in Ba overenrichment in crops,which may adversely affect human health.However,the transport and isotopic fractionation of Ba in plants remain poorly understood.We analyzed the Ba content and isotopic composition of three crops(rice,pak choi,and maize)grown in Ba-contaminated soil.Results for rice and maize demonstrated significant fractionation and environmental sensitivity in the transport of Ba,and longer flooding durations were found to increase Ba accumulation in rice grains during the filling stage.In contrast,research on pak choi revealed limited fractionation and strong uptake and transport of Ba.The estimated daily intake of Ba in the edible portion of pak choi(stems and leaves)was 15-24times the recommended daily intake of 0.2 mg/kg body weight per day.Therefore,pak choi was the least suitable crop for Ba-contaminated areas.This study provides new insights into how Ba isotopic fractionation can trace Ba transport in crops,offering practical applications for food safety and environmental monitoring.
基金supported by the National Key Research and Development Program of China(2024YFD1900101)the National Natural Science Foundation of China(42477364 and 42207398)+1 种基金the Hengyang Station,Chinese Agrosystem Long-Term Observation Network(CALTON-HY)the Jinggang Mountains Agricultural High-tech District Provincial Special Science and Technology,China(20222-051246)。
摘要Lime application represents an established approach for ameliorating soil acidity,and understanding its effects on the interactions between aluminum(Al)and iron(Fe)oxides and soil organic carbon(SOC)fractions is essential for promoting sustainable agricultural practices that enhance carbon sequestration.This investigation examined the interactions among Al and Fe oxides and SOC fractions under long-term fertilization and liming.A long-term field experiment was implemented with five treatments:CK(no fertilizer),N(nitrogen fertilizer),NCa(N plus lime),NPK(nitrogen,phosphorus,and potassium fertilizer),and NPKCa(NPK plus lime).Soil samples were obtained from three depths:0-10,10-20,and 20-30 cm.The findings revealed that lime application increased SOC by 20.84%under the N treatment but decreased SOC by 9.97%under NPK.At the 0-10 cm depth,dissolved organic carbon(DOC)was substantially higher under NCa(410.51 mg kg-1)and NPKCa(372.83 mg kg-1)compared with CK.Particulate organic carbon(POC)and mineral-associated organic carbon(MAOC)demonstrated consistent enhancement under NPK and NPKCa across all soil depths compared with CK.DOC exhibited significant positive correlations with both aluminum(Ald),reactive aluminum(Alo)and aluminum(Alp),indicating a key role of organically bound and reactive Al in carbon dynamics.Compared to the CK treatment,SOC stock increased significantly by 43.49%under NPK and by 36.82%under NPKCa.Structural equation modeling demonstrated that lime application mitigated the negative effects of free Al(Ald)on carbon sequestration,while Fe oxides(Fed)contributed positively to SOC stabilization.DOC showed no significant impact on carbon sequestration rate(CSR),while easily oxidizable carbon(EOC)negatively affected CSR directly.These results highlight the crucial role of lime in improving acidic soil conditions and enhancing the stability and sequestration of soil organic carbon.
基金supported by Ajman University Internal Research Grant No.(DRGS Ref.2024-IRGHBS-3).
摘要Fractional discrete systems can enable the modeling and control of the complicated processes more adaptable through the concept of versatility by providing systemdynamics’descriptions withmore degrees of freedom.Numerical approaches have become necessary and sufficient to be addressed and employed for benefiting from the adaptability of such systems for varied applications.A variety of fractional Layla and Majnun model(LMM)system kinds has been proposed in the current work where some of these systems’key behaviors are addressed.In addition,the necessary and sufficient conditions for the stability and asymptotic stability of the fractional dynamic systems are investigated,as a result of which,the necessary requirements of the LMM to achieve constant and asymptotically steady zero resolutions are provided.As a special case,when Layla and Majnun have equal feelings,we propose an analysis of the system in view of its equilibrium and fixed point sets.Considering that the system has marginal stability if its eigenvalues have both negative and zero real portions,it is demonstrated that the system neither converges nor diverges to a steady trajectory or equilibrium point.It,rather,continues to hover along the line separating stability and instability based on the fractional LMM system.