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Synthetic metabolic engineering of functional crops:Boosting nutrition and human health 认领 引用 被引量：5
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作者 Nan Chai Jie Xu +12 位作者 Ruixiang Zhang Guangzhou Li Jun Wen Liying Su Yang Xue Tie Li Jialin Liu Dongchang Zeng Jiantao Tan Jiaqi Huang Letian Chen Yao-Guang Liu Qinlong Zhu 《The Crop Journal》 SCIE CSCD 2026年第1期8-21,共14页
A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synth... A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synthetic metabolic engineering offers a method to modify and redesign metabolic pathways to increase the nutritional value of crops.We summarize recent advances in the biofortification of key nutrients including provitamin A,vitamin C,vitamin B9,iron,zinc,anthocyanins,flavonoids,and unsaturated fatty acids.We discuss the potential of multi-gene stacking,gene editing,enzyme engineering,and artificial intelligence in synthetic metabolic engineering.We propose future research directions and potential solutions centered on leveraging AI-driven systems biology,precision gene editing,enzyme engineering,agrobacterium-mediated genotype-independent transformation,and modular metabolic engineering strategies to develop next-generation nutritionally enhanced super crops and transform global food systems. 展开更多
关键词 Synthetic biology Synthetic metabolism engineering Functional crops Multigene stacking and gene editing Artificial intelligence
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Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes 认领 引用 被引量：4
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作者 Yu-Qi Shao Yong-Chen Wang +6 位作者 Lu Wang Hang-Ze Ruan Yun-Feng Liu Ti-Hui Zhang Shi-Jun Weng Xiong-Li Yang Yong-Mei Zhong 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期800-810,共11页
Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission ... Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission are associated with pathophysiological and neurodegenerative disorders,whereas glucagon-like peptide-1 has demonstrated neuroprotective effects.However,it is not yet clear whether diabetes causes alterations in inhibitory input to retinal ganglion cells and whether and how glucagon-like peptide-1 protects against neurodegeneration in the diabetic retina through regulating inhibitory synaptic transmission to retinal ganglion cells.In the present study,we used the patch-clamp technique to recordγ-aminobutyric acid subtype A receptor-mediated miniature inhibitory postsynaptic currents in retinal ganglion cells from streptozotocin-induced diabetes model rats.We found that early diabetes(4 weeks of hyperglycemia)decreased the frequency of GABAergic miniature inhibitory postsynaptic currents in retinal ganglion cells without altering their amplitude,suggesting a reduction in the spontaneous release ofγ-aminobutyric acid to retinal ganglion cells.Topical administration of glucagon-like peptide-1 eyedrops over a period of 2 weeks effectively countered the hyperglycemia-induced downregulation of GABAergic mIPSC frequency,subsequently enhancing the survival of retinal ganglion cells.Concurrently,the protective effects of glucagon-like peptide-1 on retinal ganglion cells in diabetic rats were eliminated by topical administration of exendin-9-39,a specific glucagon-like peptide-1 receptor antagonist,or SR95531,a specific antagonist of theγ-aminobutyric acid subtype A receptor.Furthermore,extracellular perfusion of glucagon-like peptide-1 was found to elevate the frequencies of GABAergic miniature inhibitory postsynaptic currents in both ON-and OFF-type retinal ganglion cells.This elevation was shown to be mediated by activation of the phosphatidylinositol-phospholipase C/inositol 1,4,5-trisphosphate receptor/Ca2+/protein kinase C signaling pathway downstream of glucagon-like peptide-1 receptor activation.Moreover,multielectrode array recordings revealed that glucagon-like peptide-1 functionally augmented the photoresponses of ON-type retinal ganglion cells.Optomotor response tests demonstrated that diabetic rats exhibited reductions in visual acuity and contrast sensitivity that were significantly ameliorated by topical administration of glucagon-like peptide-1.These results suggest that glucagon-like peptide-1 facilitates the release ofγ-aminobutyric acid onto retinal ganglion cells through the activation of glucagon-like peptide-1 receptor,leading to the de-excitation of retinal ganglion cell circuits and the inhibition of excitotoxic processes associated with diabetic retinopathy.Collectively,our findings indicate that theγ-aminobutyric acid system has potential as a therapeutic target for mitigating early-stage diabetic retinopathy.Furthermore,the topical administration of glucagon-like peptide-1 eyedrops represents a non-invasive and effective treatment approach for managing early-stage diabetic retinopathy. 展开更多
关键词 diabetic retinopathy glucagon-like peptide-1 inhibitory synaptic transmission miniature inhibitory postsynaptic currents neurodegeneration neuroprotection patch-clamp recording protein kinase C signaling pathway visual function
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Functional near-infrared spectroscopy:Systematic mapping of abnormal brain function features in neurological disorders 认领 引用 被引量：1
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作者 Yunjie Li Yangyang Feng +6 位作者 Xia Liu Ruochao Yuan Shiling Chen Jingyi Wang Chao Pan Gaigai Li Zhouping Tang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第10期4506-4522,共17页
Functional near-infrared spectroscopy quantifies cerebral hemodynamic signals by capturing oxygenation-dependent changes in hemoglobin in a noninvasive,portable,and ecologically valid manner,providing a unique insight... Functional near-infrared spectroscopy quantifies cerebral hemodynamic signals by capturing oxygenation-dependent changes in hemoglobin in a noninvasive,portable,and ecologically valid manner,providing a unique insight into neurovascular coupling.However,functional imaging biomarkers with high ecological validity for neurological disorders such as stroke,Parkinson's disease,dementia,amyotrophic lateral sclerosis,epilepsy,spinal cord injury,and traumatic brain injury are lacking,limiting the mechanistic understanding,treatment evaluations,and individualized interventions.The aim of this review is to systematically summarize evidence from the past decade on the use of functional near-infrared spectroscopy under the aforementioned conditions,synthesize its value for revealing neural mechanisms and assessing therapeutic responses,and identify current technical bottlenecks and future directions for advancement.Collectively,the findings demonstrate that functional near-infrared spectroscopy possesses substantial and far-reaching potential for uncovering the neural mechanisms underlying disease and for evaluating treatment-induced changes in brain function.Equipped with wearable probes,functional near-infrared spectroscopy can continuously and noninvasively monitor brain activity in naturalistic environments for extended periods,thereby overcoming the limitations of conventional imaging modalities that can only acquire data under restricted settings.This capability can furnish unprecedented objective neuroimaging evidence for neuroregenerative therapy research.Moreover,the portability of functional near-infrared spectroscopy allows it to be integrated into neurofeedback training systems:hemoglobin signals can be fed back to participants within milliseconds,enabling targeted,individualized,closed-loop modulation of brain function and considerably expanding the scope of hemodynamicsbased neurofeedback.When combined with other brain function assays(such as electroencephalography)and intervention techniques(such as transcranial magnetic stimulation and transcranial direct current stimulation),functional near-infrared spectroscopy also supplies high-temporal-resolution hemodynamic information,laying a critical foundation for the construction of high-precision noninvasive brain–computer interfaces,real-time cognitivestate decoding,and adaptive neuromodulation.Admittedly,almost all existing functional near-infrared spectroscopy studies are still observational and have small sample sizes,short follow-ups,and insufficient controls—shortcomings that together produce low-grade evidence.Therefore,there is still a significant gap before clinical translation can be achieved.Technically,the limited penetration depth of functional near-infrared spectroscopy restricts sampling to the superficial cortex,leaving deep nuclei largely unreachable.In addition,no consensus exists across devices regarding optode layout,light-source choice,motion-artifact correction,or analytical pipelines,creating pronounced heterogeneity that undermines reproducibility.With artificial intelligence and big data analytics advancing rapidly,functional near-infrared spectroscopy embedded within multimodal fusion frameworks is now poised to systematically map aberrant brain function signatures of neurological disorders,identify pathological regions suitable for targeted intervention,and provide real-time assessments of functional changes produced by neuroregenerative therapies. 展开更多
关键词 biomarkers brain mapping clinical translational application functional connectivity functional near-infrared spectroscopy multimodal fusion nervous system diseases neuroimaging neuroregenerative therapy neurovascular coupling
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Interfacial plugging of shale microfractures using functionalized graphene oxide with high dispersion stability under harsh conditions 认领 引用 被引量：1
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作者 Dao-Xiong Li Yang Bai +5 位作者 Cheng Wang Na Su Ling-Feng Wu Deng Gu Yu-Fen Zhai Ping-Ya Luo 《Petroleum Science》 SCIE EI CAS CSCD 2026年第1期422-433,共12页
Shale gas development often suffers from wellbore instability due to microfractures in the formation,posing serious challenges to drilling safety and efficiency.This study presents a functionalized graphene oxide(GO-P... Shale gas development often suffers from wellbore instability due to microfractures in the formation,posing serious challenges to drilling safety and efficiency.This study presents a functionalized graphene oxide(GO-PAA)nanomaterial,prepared by grafting hydrophilic polyacrylic acid(PAA)chains onto GO surfaces to enhance dispersion stability under high salinity,elevated temperature,and wide pH conditions.The results indicate that GO-PAA effectively resists charge-shielding effects under conditions of high salinity,elevated temperature,and a wide pH range,significantly reducing the risk of particle aggregation.Even at high salt concentrations,the zeta potential remains below-32.8 mV,demonstrating good colloidal stability.Plugging performance was evaluated using simulated core experiments.GO-PAA fo rmed a"band-aid"like barrier on shale microfracture surfaces,reducing permeability by up to57.53%,nearly twice that of conventional spherical nano particles.Scanning electron microscope(SEM)and elemental analysis confirmed the formation of a dense and uniform plugging layer.The synergistic interaction between GO's 2D lamellar structure and the flexible polymer chains facilitated effective surface adhesion and coverage.This adsorption-adhesion plugging mechanism represents a shift from traditional bridging theories,enabling reduced material usage and improved efficiency.The findings provide theo retical and practical support for designing high-perfo rmance nanoplugging agents in waterbased drilling fluids,contributing to safer and more sustainable shale gas development. 展开更多
关键词 Functionalized GO Stable dispersion Interfacial plugging Nanoplugging agent Shale microfractures
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New functional metal-organic framework(MOF) based optical thermometer by the post-synthesis doping rare earth ions into MOF 认领 引用 被引量：1
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作者 Ying Zhao Yin-Hang Chai +4 位作者 Meng-Meng Zhai Qin-Ying Jin Xiaoyan Lu Yi-Dan Qiao Lu-Fang Ma 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第1期644-649,共6页
Ln@MOFs by anchoring rare metal ions(Ln) into metal-organic frameworks(MOFs) are proved to have great potential in the field of luminescent molecular thermometer.Nevertheless,the current research indicated that the po... Ln@MOFs by anchoring rare metal ions(Ln) into metal-organic frameworks(MOFs) are proved to have great potential in the field of luminescent molecular thermometer.Nevertheless,the current research indicated that the poor structural stability and low sensitivity hindered their application scope.In this work,a new MOF Zn-450 luminescent thermometer with multiple emission fluorescence characteristics was synthesized by the combination of 3,3,5,5-biphenyl tetracarboxylic acid(H4L) and Zn2+ ion under solvothermal conditions.Interestingly,a high relative sensitivity of 1.43 % K-1 was found within 80-300 K based on Zn-450.Subsequently,two high-sensitivity luminescent Ln@MOFs(Ln = Eu and Tb) were further fabricated by doping rare earth ions into Zn-450 based on the post-synthesis strategy.Among them,the Eu@Zn-450 demonstrates various luminous behaviors while achieving an increased relative sensitivity of 1.63 % K-1.In addition,the continuously visible red,pink,and purple luminescent emissions at the same temperature range were observed,suggesting that the Eu@Zn-450 could be utilized as a luminescent colorimetric molecular thermometer.Importantly,this work can present new possibilities for the development of rare earth-doped luminescence and its temperature sensing properties. 展开更多
关键词 MOFs Optical thermometer Post-synthesis functionalization Rare metal ions LED
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Genome-wide association study of HBV-related hepatocellular carcinoma identifies a functional variant at the FAM114A1 locus 认领 引用 被引量：1
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作者 Hong-Ping Yu Bang-De Xiang +29 位作者 Ji Qian Hongliang Liu Yuan-Feng Li Qiuling Lin Shun Liu Junjie Wei Shicheng Zhan Binbin Jiang Juncheng Dai Liang Ma Litu Zhang Yingchun Liu Qiuping Wen Wenfeng Gong Shengping Li Yanji Jiang Ji Zheng Tianyi Zhu Zihan Zhou Xiaoyun Zeng Ziliang Wang Ji-Ao Wang Rui Guo Yuan Yang Qingyi Wei Gangqiao Zhou Xiao-Qiang Qiu Weizhong Tang Mengyun Wang Ruoxin Zhang 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第4期643-654,共12页
Liver cancer ranks sixth in cancer incidence and third in cancer-related deaths worldwide.Hepatocellular carcinoma(HCC)is the primary histological subtype,and hepatitis B virus(HBV)carriers have a higher risk of HCC.A... Liver cancer ranks sixth in cancer incidence and third in cancer-related deaths worldwide.Hepatocellular carcinoma(HCC)is the primary histological subtype,and hepatitis B virus(HBV)carriers have a higher risk of HCC.Although several susceptibility loci for HCC have been identified in East Asian populations through genome-wide association studies(GWAS),the underlying biological mechanisms of this malignancy remain incompletely understood.Here,we conduct a two-stage GWAS including 2413 cases and 2794 HBV-positive controls from a high-incidence region in Southern China.The function of the susceptibility locus is investigated by bioinformatic and experimental approaches,supported by a xenograft model.We identify a 4p14 locus significantly associated with the risk of HCC(rs55718051,OR[95%CI]=0.73[0.67-0.80],Pmeta=9.14×10-11),and 18q23 locus with borderline significance(rs12964643:OR[95%CI]=0.75[0.67-0.83],Pmeta=1.11×10-7).Functional experiments indicate the role of rs55718051 in FAM114A1 expression regulation,possibly through the interaction with FOXA1.Knockdown of FAM114A1 significantly promote the oncogenic phenotypes in liver cancer cells,suggesting its potential tumor suppressor role.Our findings expand the understanding of HCC susceptibility and suggest FAM114A1 as a potential suppressor in HBV-related HCC carcinogenesis. 展开更多
关键词 Hepatocellular carcinoma Hepatitis B virus Genome-wide association study Functional variant Cancer susceptibility
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Definition of critical skin defect and concepts of structural and functional repairs:Proposal and verification in a rat model 认领 引用 被引量：1
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作者 Cong Sun Weihong Guo +4 位作者 Fang Liang Rabia Javed Weijian Hou Xingdong Zhang Qiang Ao 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第1期168-182,共15页
Background:Rats are often used to prepare skin defect models.However,the skin defect sizes of the models prepared by researchers are different,and the lack of consensus on the critical-size defect makes it difficult t... Background:Rats are often used to prepare skin defect models.However,the skin defect sizes of the models prepared by researchers are different,and the lack of consensus on the critical-size defect makes it difficult to compare their research results.Methods:The time for wound closure was evaluated and recorded through gross observation.The regression equation between the healing time and the diameter of skin defect was established,which can be used to predict the healing time for a certain skin defect size in rats.Histochemical and immunohistochemical staining was used to observe the regeneration and reconstruction of skin appendages,and the functional skin repair was quantitatively scored.Results:The critical-size defect of rats was determined based on the maximum capacity of structural skin repair,and the functional skin repair was quantitatively scored based on the regeneration and reconstruction of skin appendages.The allowable range of critical-size skin defect of SD rats lies between 45 and 50 mm in diameter.The concept of structural repair and the category of functional repair of injured skin are put forward.The regression equation between the structural skin healing time and defect diameters is established.Conclusion:The allowable range of skin critical-size defect of SD rats lies between 45 and 50 mm in diameter.The regression equation between the structural skin healing time and defect diameters can be used to predict the healing time for a certain skin defect size in rats. 展开更多
关键词 critical defect functional repair quantitative evaluation skin defect structural repair
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Influence of aerobic exercise on the cognitive and social functions of elderly patients with schizophrenia 认领 引用 被引量：1
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作者 Can Ao Lu Zhan +2 位作者 Yu-Lan Mou Shu Hu Yong-Hong Huang 《World Journal of Psychiatry》 SCIE 2026年第3期180-190,共11页
BACKGROUND Schizophrenia presents complex challenges in older patients due to cognitive and social decline.Existing drug treatments offer limited benefits and pose risks,while aerobic exercise shows promise as a nonin... BACKGROUND Schizophrenia presents complex challenges in older patients due to cognitive and social decline.Existing drug treatments offer limited benefits and pose risks,while aerobic exercise shows promise as a noninvasive intervention whose impact remains underexplored.AIM To investigate the effects of aerobic exercise on cognitive and social function in older patients with schizophrenia.METHODS A retrospective study was conducted in 158 older patients with schizophrenia treated at The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College(June 2023 and December 2024).The patients were divided into an observation group(n=86),which received 3 months of aerobic rehabilitation alongside routine treatment,and a control group(n=72),which received routine treatment alone.Cognitive function was assessed using the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery,social function using the Inpatient Psychiatric Rehabilitation Outcome Scale(IPROS),and psychotic symptoms using the Positive and Negative Syndrome Scale.RESULTS Post-treatment,Positive and Negative Syndrome Scale total scores were lower in the observation group than in the controls(P<0.001),with significant improvements in positive,negative,and general symptoms.Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery domain scores were improved in processing speed,working memory,verbal/visual learning,and executive function(all P<0.05).IPROS total scores were decreased(P<0.001),indicating better social functioning.Longer exercise duration correlated with greater cognitive gains and lower social function deficits.Body mass index declined(P<0.001),and adverse events were mild and transient(9.3%).Multivariate linear regression confirmed that aerobic exercise was independently associated with a significant reduction in IPROS scores(Adjustedβ=-4.57,95%confidence intervals:-6.08 to-3.05,P<0.001).CONCLUSION Aerobic exercise effectively improves cognitive function,social function,and psychotic symptoms in older patients with schizophrenia,is safe,and serves as a valuable adjunctive intervention. 展开更多
关键词 Schizophrenia Aerobic exercise Cognitive function Social function Elderly patients
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Dynamic Mechanisms of Land Use Conflict Under Main Function Oriented Zone Planning:A Case Study of Beijing-Tianjin-Hebei Region 认领 引用 被引量：1
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作者 ZHENG Yang CHENG Linlin +2 位作者 WANG Junqi WANG Yifang CUI Huizhen 《Chinese Geographical Science》 SCIE CAS CSCD 2026年第2期320-336,共17页
Systematically analyzing the impact mechanisms of policy on Land Use Conflict(LUC)is crucial for constructing effective conflict mitigation strategies.However,previous research on how policy influences LUC remains rel... Systematically analyzing the impact mechanisms of policy on Land Use Conflict(LUC)is crucial for constructing effective conflict mitigation strategies.However,previous research on how policy influences LUC remains relatively limited.Focusing on the indirect driving role of policy on LUC,this study proposed County Development Level(CDL)under Major Function Oriented Zone Planning(MFOZP)guidance as an intermediary variable,bridging the implicit influence of MFOZP and the explicit changes in LUC.Using the Beijing-Tianjin-Hebei(BTH)region in China as a case study,we analyzed the spatio-temporal evolution characteristics of LUC and CDL for the periods 2000-2010 and 2010-2020,before and after MFOZP implementation.Panel models and Geographically Weighted Regression(GWR)were employed to explore the mechanism by which CDL influences LUC under MFOZP guidance.The results show that:1)MFOZP implementation effectively alleviates land use pressure from regional development,with LUC continuously declining at a rate of 2.41%,while CDL exhibits slight growth(3.84%),during 2010-2020.2)Under MFOZP guidance,CDL reduces pressure on Land Use Structure Conflict(LUSC)and Land Use Process Conflict(LUPC),enhances its inhibitory effect on Land Use Function Conflict(LUFC),and significantly contributes to LUC coordination,with notable spatial heterogeneity.3)The coupling relationship between CDL and LUC has improved post-implementation.Based on this,tailored LUC coordination strategies are proposed for different functional zones.This study confirms the effectiveness of MFOZP in coordinating LUC and provides a scientific reference for LUC research under policy frameworks and the governance of LUC in the BTH region. 展开更多
关键词 Land Use Conflict(LUC) Major Function Oriented Zone Planning(MFOZP) County Development Level(CDL) Beijing-Tianjin-Hebei(BTH)region,China
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Dual-charged,non-swelling amine/carboxyl functionalized Fe-Mn mixed oxide composite for simultaneous removal of anionic and cationic azo dyes:Experimental and DFT studies 认领 引用
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作者 Afsar Khan Ran Hong +4 位作者 Saisai Chen Tingting Liu Savas Kaya Weihua Chen Dayong Xu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2026年第2期214-231,共18页
Iron(Fe)and manganese(Mn)mixed oxide composites are widely recognized for their excellent adsorption performance in wastewater treatment.However,their functionalization for simultaneous removal of both anionic and cat... Iron(Fe)and manganese(Mn)mixed oxide composites are widely recognized for their excellent adsorption performance in wastewater treatment.However,their functionalization for simultaneous removal of both anionic and cationic contaminants remains underexplored.In this study,Fe-Mn mixed oxides were functionalized with poly(acrylic acid)(PAA)and chitosan to introduce carboxylic and amine groups respectively,forming a dual-functionalized composite(PAA-chitosan-FeMn).The material was evaluated for the adsorption of Congo red,reactive blue 19,and methylene blue from aqueous solutions using batch and fixed-bed reactor systems.The composite was characterized before and after adsorption using X-ray photoelectron spectroscope(XPS),atomic force microscope,scanning electron microscope,high-resolution transmission electron microscope,Fourier transform infrared spectroscope(FTIR),thermal gravimetric analyzer,and Raman spectroscopy.A marked enhancement in adsorption capacity was observed for all target dyes.Mechanistic investigations using XPS,FTIR,and density functional theory(DFT)indicated that the adsorption process was predominantly governed by electrostatic interactions and hydrogen bonding involving carbon,nitrogen,and oxygen functional groups.XPS analysis further confirmedthe active role of Fe and Mn ions in dye binding.Comprehensive studies on adsorption isotherms,kinetics,and thermodynamics were conducted under optimized conditions.The composite exhibited a specificsurface area of 27.4 to 68.4 m2·g-1before and after dye adsorption and a point of zero charge of 6.5-6.8,facilitating effective adsorption of oppositely charged dyes at nearneutral pH.Batch adsorption experiments demonstrated maximum capacities of 95.0%to 99.7% for both dyes under optimal conditions(pH 8-10,298 K).The PAA-chitosan-FeMn composite demonstrated high adsorption capacity,excellent stability under acidic conditions,and strong selectivity,highlighting its potential for the effective and simultaneous removal of anionic and cationic azo dyes from wastewater. 展开更多
关键词 Functionalization Adsorption Fixed-bed Synthesis DFT calculations Composites
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Functional characterization of OsLT9 in regulating rice leaf thickness 认领 引用
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作者 Jian Wang Dagang Chen +9 位作者 Haifei Hu Yamei Ma Tifeng Yang Jie Guo Ke Chen Chanjuan Ye Juan Liu Xinqiao Zhou Chuanguang Liu Junliang Zhao 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第2期223-233,共11页
Leaf thickness in rice critically influences photosynthetic efficiency and yield,yet its genetic basis remains poorly understood,with few functional genes previously characterized.In this study,we employ a pangenome-w... Leaf thickness in rice critically influences photosynthetic efficiency and yield,yet its genetic basis remains poorly understood,with few functional genes previously characterized.In this study,we employ a pangenome-wide association study(Pan-GWAS)on 302 diverse rice accessions from southern China,identifying 49 quantitative trait loci(QTLs)associated with leaf thickness.The most significant locus,qLT9,is fine-mapped to a 79-kb region on chromosome 9.Transcriptomic and genomic sequence analyses identify LOC_Os09g33480,which encodes a protein belonging to Multiple Organellar RNA Editing Factor family,as the key candidate gene.Overexpression and complementation transgenic experiments confirm LOC_Os09g33480(OsLT9)as the functional gene underlying qLT9,demonstrating a 24-bp Indel in its promoter correlates with the expression levels and leaf thickness.Notably,OsLT9 overexpression lines show not only thicker leaf,but also significantly enhanced photosynthetic efficiency and grain yield,establishing a link between leaf thickness modulation and yield enhancement.Population genomic analyses indicate strong selection for OsLT9 during domestication and breeding,with modern cultivars favoring thick leaf haplotype of OsLT9.This study establishes OsLT9 as a key regulator controlling leaf thickness in rice,and provides a valuable genetic resource for molecular breeding of high-yielding rice through optimization of plant architecture. 展开更多
关键词 Rice Leaf thickness GWAS Functional gene OsLT9
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Nickel-Catalyzed Borylation of Aryl Nonaflates for the Efficient Synthesis of Arylboronates via C—O Bond Functionalization 认领 引用
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作者 Liang Yuan Gui Chao +3 位作者 Wang Wenwen Chu Xueqiang Xu Hao Shen Zhiliang 《有机化学》 SCIE CAS CSCD 北大核心 2026年第1期207-214,共8页
Nickel-catalyzed borylation of aryl nonaflates with B2pin2 could be realized,which proceeded effectively by means of C—O bond functionalization to afford a wide variety of valuable arylboronates in moderate to excell... Nickel-catalyzed borylation of aryl nonaflates with B2pin2 could be realized,which proceeded effectively by means of C—O bond functionalization to afford a wide variety of valuable arylboronates in moderate to excellent yields with good functionality compatibility.In addition,the gram-scale synthesis and the application of the approach in the late-stage elaboration of aryl nonaflate derived from pterostilbene could also be achieved. 展开更多
关键词 nickel catalysis borylation aryl nonaflates arylboronates C-O bond functionalization
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Validation of a multi-layer approach-based ionospheric mapping function supporting PPP-AR 认领 引用
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作者 Jacek Paziewski MMainul Hoque +5 位作者 Rafal Sieradzki Olaf Frauenberger Pawel Wielgosz Narayan Dhital Grzegorz Nykiel Raul Orus Perez 《Satellite Navigation》 SCIE EI CSCD 2026年第1期263-278,I0006,共16页
One possibility to support Precise Point Positioning with integer Ambiguity Resolution(PPP-AR)is the application of slant ionospheric corrections converted using ionospheric Mapping Functions(MF)from Vertical Total El... One possibility to support Precise Point Positioning with integer Ambiguity Resolution(PPP-AR)is the application of slant ionospheric corrections converted using ionospheric Mapping Functions(MF)from Vertical Total Electron Content(VTEC).In such a case,the accuracy of the ionospheric corrections is driven by the uncertainties introduced by both VTEC and MF.Focusing on the ionospheric mapping functions,we note that a Single Layer Model(SLM)MF,which is conventionally used in GNSS positioning,is less effective for regions with high TEC gradients.Hence,in this study,we validate the performance of a new Multi-Layer(ML)approach-based ionospheric mapping function responding to the limitations of the conventional SLM MF.The new ML MF,based on the Neustrelitz Total Electron Content model,leverages the concept of dividing the ionosphere into several thin shells.Consequently,the ratio of aggregated Slant TEC(STEC)and VTECs provides the mapping factors.We validate the MF based on both PPP positioning and GNSS observation domains.We used data from nine GNSS stations distributed in three ionosphere sectors,namely high,middle,and low latitudes,with different daily patterns of the ionosphere.We report a benefit from applying the new multi-layer approach-based MF for PPP performance compared to positioning with a standard SLM.The advances are the most noticeable during the positioning initialization period and,therefore,are reflected in a faster convergence of the fixed solution by 4–10%,on average.The analysis in the GNSS observation domain based on geometry-free linear combination revealed the highest potential of the ML mapping function for the equa torial region. 展开更多
关键词 Ionosphere GNSS positioning PPP Mapping function
Influence of functional diversity on aboveground biomass accumulation in subtropical sub montane forests 认领 引用
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作者 Muhammad MAJEED Akash JAMIL +5 位作者 GAO Yongheng Ghulam YASIN Umair YOUNAS Elena PISMENNAYA Ksenia MYACHINA Nasir QADIR 《Journal of Mountain Science》 SCIE CSCD 2026年第3期1136-1146,共11页
Subtropical evergreen sub-montane forests in Punjab,Pakistan,are vital for carbon sequestration and play an essential role in supporting local communities.While the global importance of tree species diversity in enhan... Subtropical evergreen sub-montane forests in Punjab,Pakistan,are vital for carbon sequestration and play an essential role in supporting local communities.While the global importance of tree species diversity in enhancing aboveground carbon(AGC)storage is well established,there remains limited empirical evidence from Pakistan’s forest ecosystems.This study investigated how taxonomic and functional diversity,alongside topographical variables,influence AGC across four districts in Punjab.Taxonomic metrics such as the Importance Value Index(IVI)and genus richness were computed,along with functional diversity indices including functional richness(FRic),functional dispersion(FDis),functional divergence(FDiv),and functional evenness(FEve).AGC was estimated using species-specific allometric equations,and linear mixed-effects models were applied to identify the most influential predictors.Acacia modesta and A.nilotica emerged as the dominant species in the studied sites.While species richness and biomass increased with elevation,Shannon diversity showed a negative relationship with elevation.AGC values ranged from 100 to 350 Mg ha-1across the study sites.Among diversity metrics,FRic(0.042)and FDis(0.342)were significantly associated with higher AGC,whereas taxonomic diversity measures showed weaker correlations.Although elevation was a strong predictor of diversity patterns,it did not have a significant direct effect on carbon storage.These findings underscore the importance of incorporating functional trait diversity and topographic variability into forest management strategies to enhance carbon sequestration,strengthen ecosystem resilience and support sustainable rural livelihoods. 展开更多
关键词 Functional diversity Altitude Aboveground biomass Biodiversity Subtropical forests Carbon storage
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Work function engineering of MXene contacts for high-performance,self-powered AlGaN solar-blind photodetectors 认领 引用
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作者 Pan Dai Dengshan Cai +12 位作者 Wenxian Yang Ying Gu Haowen Hua Mengyang Huang Peng Zhang Xueyan Feng Sijia Wei Zheng Zhong Yi Gong Jianjun Zhu Shan Jin Shulong Lu Min Jiang 《Chinese Physics B》 SCIE EI CAS CSCD 2026年第6期878-885,共8页
AlGaN-based solar-blind UV photodetectors are crucial for critical applications but suffer from Fermi-level pinning that leads to high dark current.Constructing a high-barrier heterojunction interface effectively supp... AlGaN-based solar-blind UV photodetectors are crucial for critical applications but suffer from Fermi-level pinning that leads to high dark current.Constructing a high-barrier heterojunction interface effectively suppresses dark current,yet controlling the AlGaNwo-dimensional material barrier via work function modulation remains challenging.Here,we tailor the work function of MXene(3.7–4.6 eV)through surface oxidation to fabricate self-powered MXene/AlGaN van der Waals photodetectors.By alleviating Fermi-level pinning and forming a deep-depletion barrier,the device exhibits a suppression of dark current by nearly four orders of magnitude at 0 V(10-14A regime).Consequently,the device achieves a high responsivity of 15 mA/W and a specific detectivity of 2×1011Jones at 280 nm,accompanied by a rapid response time of 0.66 ms.This work validates work function engineering as a potent strategy for optimizing interface energetics and boosting the performance of wide-bandgap optoelectronics. 展开更多
关键词 AlGaN MXene solar-blind photodetector work function engineering van der Waals heterojunction
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Augment of partial nitrification/anammox in biosorption/partial nitrification/anammox process by using functionalized carriers for energy self-sufficient mainstream municipal wastewater treatment 认领 引用
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作者 Tao Liu Xin Liu +3 位作者 Zhaodong Li Sen Qiao Shuo Chen Xie Quan 《ENGINEERING Environment》 SCIE EI CAS CSCD 2026年第2期43-56,共14页
The high energy consumption of conventional activated sludge process is posing significant challenge on the current wastewater industry worldwide.Therefore,the development of energy-efficient wastewater treatment proc... The high energy consumption of conventional activated sludge process is posing significant challenge on the current wastewater industry worldwide.Therefore,the development of energy-efficient wastewater treatment processes is urgently needed.This study proposed an energy self-sufficient biosorption/partial nitrification/anammox process by using functionalized carriers to augment the efficiency of partial nitrification and anammox.Specifically,in biosorption stage,COD was captured into sludge,which could further be converted into bio-methane by anaerobic digestion for energy recovery.In the partial nitrification stage,nitrification-functionalized carriers were used for selective enrichment of ammonia-oxidizing bacteria(AOB)to maintain efficient and stable nitrite accumulation,while anammox-functionalized carriers were utilized in anammox stage for massive anammox bacteria accumulation.Long-term operation results showed that with an averaged influent COD concentration of 200.0 mg/L and total nitrogen(TN)concentration of 60.0 mg/L,the effluent consistently achieved an average COD concentration of 25.4 mg/L and an average TN concentration of 13.6 mg/L,which could meet the national discharge standard(GB18918-2002,China).The use of nitrification-functionalized carriers promoted the survival and enrichment of AOB,while anammox-functionalized carriers similarly facilitated the survival and enrichment of anammox bacteria.The effective colonization resulted in a significant upregulation of genes associated with nitrogen metabolism.This study proposes a novel approach for the in-situ selective enrichment of AOB and anammox bacteria to realize efficient partial nitrification-anammox process,which holds potential for achieving energy-neutral mainstream municipal wastewater treatment with low carbon emissions. 展开更多
关键词 Biosorption Partial nitrification Anammox Functionalized carrier Municipal wastewater
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Efficacy and safety of lansoprazole combined with flupentixolmelitracen for functional dyspepsia:A randomized,double-blinded,placebo-controlled clinical trial 认领 引用
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作者 Xin-Yuan Wang Ke-Han Yin +6 位作者 Li Cheng Xiao-Yu Wang Ying Qiao Xing-Ru Tang Bo Wang Xiu-Juan Yan Sheng-Liang Chen 《World Journal of Gastroenterology》 SCIE CAS 2026年第13期66-77,共12页
BACKGROUND Psychosocial factors play a major role in the pathogenesis of functional dyspepsia(FD);however,there is a paucity of evidence from randomized controlled trials supporting the use of neuromodulators in FD.AI... BACKGROUND Psychosocial factors play a major role in the pathogenesis of functional dyspepsia(FD);however,there is a paucity of evidence from randomized controlled trials supporting the use of neuromodulators in FD.AIM To evaluate the efficacy and safety of lansoprazole(LPZ)combined with flupentixol-melitracen(FM)in FD.METHODS This was a single-center,double-blind,randomized,placebo-controlled trial enrolling patients aged 18-80 years who met the Rome IV diagnostic criteria for FD.Patients with a positive Helicobacter pylori test or abnormal upper gastrointestinal endoscopy/abdominal ultrasound were excluded.Participants completed the Leuven Postprandial Distress Scale,Short Form Nepean Dyspepsia Index(SFNDI),Patient Health Questionnaire-9(PHQ-9),Generalized Anxiety Disorders-7,and Pittsburgh Sleep Quality Index.Patients were randomized 1:1 to receive LPZ(30 mg once daily)combined with FM(flupentixol 0.5 mg+melitracen 10 mg)or matched placebo for 2 weeks,followed by a 4-week follow-up.The primary endpoint was clinical response rate in the intention-to-treat population,defined as a reduction of at least 0.7 in the postprandial discomfort syndrome(PDS)score at the end of treatment among patients with a baseline PDS score of≥1.RESULTS Between March 5 and August 10,2025,183 patients were randomized to receive LPZ+FM(n=92)or LPZ+placebo(n=91).At week 2,the clinical response rate was higher in the LPZ+FM group than in the placebo group(63.0%vs 46.2%;relative risk=1.42,95%confidence interval:1.04-1.93).LPZ+FM resulted in greater reductions in PDS,SF-NDI,PHQ-9,Generalized Anxiety Disorders-7,and Pittsburgh Sleep Quality Index scores.Improvements in PDS,SF-NDI,and PHQ-9 persisted through follow-up.Adverse events were mild and occurred in 32.6%of patients receiving LPZ+FM and 23.1%receiving placebo,with no serious adverse events reported.CONCLUSION Short-term,low-dose FM combined with LPZ is an effective and safe treatment for FD. 展开更多
关键词 Flupentixol-melitracen Functional dyspepsia Lansoprazole Anxiety Deanxit
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Effect of“Tongdu Yupi Tiaoshen”electroacupuncture on behavioral performance and hippocampal structure and function in chronic fatigue syndrome rats 认领 引用
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作者 QU Yuanyuan FENG Chuwen +5 位作者 SUN Weibo SHAO Yuying LU Jing GUO Shuhao LI Binbin YANG Tiansong 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第3期605-616,共12页
OBJECTIVE:To investigate the effects of electroacupuncture intervention on behavioral performance,hippocampal structure,and function in chronic fatigue syndrome(CFS)rats and to explore the underlying mechanisms.METHOD... OBJECTIVE:To investigate the effects of electroacupuncture intervention on behavioral performance,hippocampal structure,and function in chronic fatigue syndrome(CFS)rats and to explore the underlying mechanisms.METHODS:Specific pathogen free-grade male SpragueDawley rats were randomly allocated into a control group(Con group,n=12)and a modeling group.The latter underwent a 21-d CFS induction via an improved chronic multi-factor compound stress stimulation protocol.Successfully modeled CFS rats were then randomly assigned to a model group(Mod group,n=12)and an electroacupuncture group(EA group,n=12).During the 14-d treatment period,both the Mod and EA groups continued to receive chronic stress stimuli.Rats in the EA group received electroacupuncture at Shenting(GV24)through to Baihui(GV20),with additional stimulation on Dazhui(GV14).Each session lasted 15 min,administered twice daily with a 6-h interval between morning and afternoon treatments.After modeling and treatment,the general semi-quantitative score(GSQS)was used to evaluate the rats'general health,while the Morris water maze test(MWMT),open field test(OFT),and exhaustive treadmill test(ETT)were applied to assess their learning/memory,emotional state,and fatigue levels,respectively(n=12 per group).After the treatment phase,cerebral glucose metabolism was assessed by 1fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)imaging(n=3 per group),while hippocampal cornu ammonis 1(CA1)morphology was examined using hematoxylin-eosin(HE)and Nissl staining(n=3 per group).RESULTS:Behavioral assessments demonstrated that electroacupuncture intervention significantly improved rat performance as measured by GSQS,MWMT,OFT,and Exhaustive Treadmill Test.Both HE and Nissl staining results confirmed that,compared with the blank control group,the model group exhibited abnormal cellular morphology,disorganized arrangement,and reduced Nissl bodies in the hippocampal CA1 region.These pathological alterations were ameliorated in the electroacupuncture group relative to the model group.18F-FDG PET/CT imaging revealed that following treatment,the mean and maximum standardized uptake values(SUV)in the anterior-dorsal and posterior hippocampus were significantly decreased in the Mod group compared to the Con group.In contrast,electroacupuncture treatment significantly increased both SUV-mean and SUV-max in these hippocampal subregions in the EA group relative to the Mod group(all P<0.05).CONCLUSION:Electroacupuncture intervention alleviated cognitive impairment,hippocampal pathological structural changes,and glucose metabolism dysfunction in a rat model of chronic fatigue syndrome induced by an improved chronic multi-factor compound stress stimulation method. 展开更多
关键词 electroacupuncture chronic fatigue syndrome cognitive dysfunction hippocampal structures hippocampal functions
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Transcriptomic and metabolomic analyses reveal the mechanism of anthocyanin metabolism in H18 pepper leaves and the function of CaDFR1 认领 引用
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作者 Han Wang Dongchen Li +7 位作者 Congsheng Yan Muhammad Aamir Manzoor Qiangqiang Ding Yan Wang Xiujing Hong Tingting Song Li Jia Haikun Jiang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第5期1949-1960,共12页
Anthocyanins play a crucial role in plant growth,development,reproduction,and stress response.Additionally,anthocyanins enhance the quality of fruits and vegetables due to their antioxidant properties.While numerous p... Anthocyanins play a crucial role in plant growth,development,reproduction,and stress response.Additionally,anthocyanins enhance the quality of fruits and vegetables due to their antioxidant properties.While numerous previous studies have been conducted on anthocyanins,limited information exists regarding their composition and the role of the anthocyanin pathway gene dihydroflavonol 4-reductase(DFR) in chili pepper leaves.In this study,we used a purple leaf pepper cultivar H18 in which the anthocyanin content in leaves decreases with plant growth and development.Targeted anthocyanin metabolite assays revealed that the contents of delphinidin,malvidin,and petunidin derivatives followed the same trend as the overall anthocyanin content,with delphinidin derivatives being the predominant component of H18pepper leaves.Transcriptome sequencing was performed on H18 leaves at four different stages.The results showed that differentially expressed genes(DEGs) at various stages were primarily associated with biological processes and flavonoid metabolic pathways.Through phylogenetic tree and expression analysis,we identified three candidate genes involved in DFR function.Substrate catalysis assays of CaDFRs demonstrated that only CaDFR1 was active,catalyzing dihydroquercetin(DHQ),dihydromyricetin(DHM),and dihydrokaempferol(DHK).VIGS-mediated silencing of CaDFR1resulted in a significant decrease in anthocyanin levels in H18 pepper leaves and stems,along with a reduction in the expression levels of other candidate functional genes in the anthocyanin metabolic pathway.This study identifies the key anthocyanin components in the leaves of H18 peppers and validates the function of CaDFR1,providing a theoretical foundation for modifying anthocyanin content in pepper plants through molecular breeding. 展开更多
关键词 anthocyanins transcriptomic and metabolomic dihydroflavonol 4-reductase functional validation
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Single and combined impacts of antibiotics on aerobic denitrification:Cell growth characteristics and functional genes expressions 认领 引用
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作者 Rong-Rong Chang Chang-Ze Shi +4 位作者 Yun-Jie Ruan Bao-Cheng Huang Ren-Cun Jin Ming Dong Wen-Bing Li 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第2期461-467,共7页
Antibiotic contamination has garnered significant attention,particularly given the growing pressures from aquaculture,a key contributor to environmental antibiotic loads.Addressing both antibiotic and nitrogen polluti... Antibiotic contamination has garnered significant attention,particularly given the growing pressures from aquaculture,a key contributor to environmental antibiotic loads.Addressing both antibiotic and nitrogen pollution in such ecosystems is critical.In this study,the aerobic denitrifying bacterium Marinobacter hydrocarbonoclasticus RAD-2,previously isolated in our laboratory,was subjected to a series of concentration gradients(0,20,40,60,80,100 mg/L)to evaluate the single and combined effects of tetracycline(TET)and chlortetracycline(CTC)on the aerobic denitrification process.Among them,the combined effects of antibiotics were set up in a full-factor experimental design(a total of 30 treatment combinations)on the basis of the single-factor experiments of TET and CTC.Results demonstrated that the inhibitory impact of both antibiotics intensified with increasing concentration,with CTC exerting a more pronounced inhibitory effect.Notably,RAD-2 was unable to proliferate at 100 mg/L of TET or 80 mg/L of CTC.High concentrations of either antibiotic significantly suppressed the expression of key denitrification functional genes,including nirX,napA,norB,and nosZ.Furthermore,simultaneous exposure to both antibiotics led to a rapid decline in nitrogen removal efficiency(TET or CTC>60 mg/L),alongside substantial inhibition of bacterial growth and functional gene expression,except for napA.Under specific concentration ranges,the combination of TET and CTC exhibits a certain degree of antagonistic effect.These findings provide critical insights into the restoration of wetland ecosystem health and inform strategies to mitigate the dual challenges of antibiotic and nitrogen pollution in aquaculture effluents. 展开更多
关键词 Antibiotics Aerobic denitrification Synergistic effects Functional genes inhibition
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