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基于大语言模型Function-calling架构的中医舌象辅助问诊系统 认领 引用
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作者 施浩然 王月明 +3 位作者 石磊 王瑾 谷宇 李琦 《科学技术与工程》 EI 北大核心 2026年第13期5583-5593,共11页
针对大语言模型缺乏视觉能力及现有多模态大模型在中医舌象分析中准确率不足的问题,构建了一个中医舌象辅助问诊系统,实现舌象的自动分类与中医辅助诊疗方案的生成。在利用UNet进行舌象分割的基础上,使用TransNeXt主干网络构建舌象多标... 针对大语言模型缺乏视觉能力及现有多模态大模型在中医舌象分析中准确率不足的问题,构建了一个中医舌象辅助问诊系统,实现舌象的自动分类与中医辅助诊疗方案的生成。在利用UNet进行舌象分割的基础上,使用TransNeXt主干网络构建舌象多标签分类系统,实现舌体分割与舌象多标签分类。进一步,结合舌象多标签分类系统与大语言模型,并基于微调后的Function-calling架构,实现了中医舌象辅助问诊系统。在舌象多标签分类系统的有效性验证实验中,UNet模型在舌象分割的平均精确度、平均召回率和平均交并比指标上表现较好,分别达到97.58%,98.61%和96.25%;基于TransNeXt主干网络开发的舌象多标签分类模型在舌象识别的子集准确率、精确度、召回率、F1方面表现更佳,分别达到75.69%、91.18%、91.41%、91.28%。在中医辅助诊疗方案的生成实验中,甄选出的最佳大语言模型相较于多模态大模型在Bleu-4、Rouge-1、Rouge-2、Rouge-L同样表现更佳,分别达到79.03%、82.46%、76.00%、86.46%。结合舌象多标签分类系统以及大语言模型构建的中医舌象辅助问诊系统能够辅助中医进行舌诊,为中医辅助诊断方案的生成提供技术支持。 展开更多
关键词 大语言模型 Function-calling架构 舌象识别 中医知识问答
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The Initial Mass Function as the Equilibrium State of a Variational Process:Why the IMF Cannot be Sampled Stochastically 认领 引用
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作者 Eda Gjergo Zhiyu Zhang Pavel Kroupa 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2026年第5期163-174,共12页
The stellar initial mass function(sIMF)is often treated as a stochastic probability distribution,yet such an interpretation implies Poisson noise that is inconsistent with growing observational evidence.In particular,... The stellar initial mass function(sIMF)is often treated as a stochastic probability distribution,yet such an interpretation implies Poisson noise that is inconsistent with growing observational evidence.In particular,the observed relation between the mass of the most massive star formed in an embedded cluster and the cluster’s total stellar mass supports a deterministic sampling process,known as optimal sampling.However,the physical origin of optimal sampling has not been formally established in the literature.In this work,we show that the stellar mass distribution implied by optimal sampling emerges from applying the Maximum Entropy principle to the fragmentation of star-forming clumps,whose structure is set by density-dependent cooling in the optically thin regime.Here,the Maximum Entropy leads to unbiased distributions.By applying calculus of variations to minimize the entropy functional obtained assuming fragmentation,we recover the power-law form of the sIMF,and we show that any distribution deviating from the sIMF violates the Maximum Entropy principle.This work provides a first-principles foundation for the deterministic nature of star formation.Thus,the sIMF is the distribution resulting from a maximally unbiased system. 展开更多
关键词 galaxies star formation-stars luminosity function,mass function-galaxies evolution
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A review for design,mechanism,fabrication,and application of magnetically responsive microstructured functional surface 认领 引用 被引量：1
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作者 Jian Wang Xingyi Song +8 位作者 Chaochao Wang Yumei Zhou Ri Chen Yong Yang Bin Liu Yihao Zheng Hui Li Wei Zhou Lelun Jiang 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2025年第1期96-128,共33页
Magnetically responsive microstructured functional surface(MRMFS),capable of dynamically and reversibly switching the surface topography under magnetic actuation,provides a wireless,noninvasive,and instantaneous way t... Magnetically responsive microstructured functional surface(MRMFS),capable of dynamically and reversibly switching the surface topography under magnetic actuation,provides a wireless,noninvasive,and instantaneous way to accurately control the microscale engineered surface.In the last decade,many studies have been conducted to design and optimize MRMFSs for diverse applications,and significant progress has been accomplished.This review comprehensively presents recent advancements and the potential prospects in MRMFSs.We first classify MRMFSs into one-dimensional linear array MRMFSs,two-dimensional planar array MRMFSs,and dynamic self-assembly MRMFSs based on their morphology.Subsequently,an overview of three deformation mechanisms,including magnetically actuated bending deformation,magnetically driven rotational deformation,and magnetically induced self-assembly deformation,are provided.Four main fabrication strategies employed to create MRMFSs are summarized,including replica molding,magnetization-induced self-assembly,laser cutting,and ferrofluid-infused method.Furthermore,the applications of MRMFS in droplet manipulation,solid transport,information encryption,light manipulation,triboelectric nanogenerators,and soft robotics are presented.Finally,the challenges that limit the practical applications of MRMFSs are discussed,and the future development of MRMFSs is proposed. 展开更多
关键词 functional surfaces microstructures magnetic actuation manipulation
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Addressing functional constipation in children:A call for comprehensive and collaborative management 认领 引用 被引量：2
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作者 Yan Pan Fu-Yong Jiao 《World Journal of Gastroenterology》 SCIE CAS 2025年第7期142-145,共4页
Functional constipation(FC)is the most common gastrointestinal disorder in children,with a global prevalence of 14.4%based on Rome IV criteria.This editorial explores the multifactorial pathogenesis and diagnostic com... Functional constipation(FC)is the most common gastrointestinal disorder in children,with a global prevalence of 14.4%based on Rome IV criteria.This editorial explores the multifactorial pathogenesis and diagnostic complexity of FC,emphasizing the importance of early and accurate diagnosis.Effective management of FC hinges on child-oriented toilet training and the use of osmotic laxatives,particularly polyethylene glycol.Emerging therapies,including probiotics,serotonin 5-HT4 receptor agonists,chloride channel activators,and herbal remedies,offer promising options but require further research.Lifestyle modifications,such as adequate fiber and fluid intake and physiotherapy,are crucial in supporting pharmacological treatments.For intractable cases,a multidisciplinary approach involving pediatric specialists,nutritionists,physiotherapists,and psychologists is essential.This comprehensive strategy aims to improve the quality of life for children with FC and their families through continuous research,education,and collaborative care. 展开更多
关键词 Functional constipation Gastrointestinal disorder Children Management
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Synthetic metabolic engineering of functional crops:Boosting nutrition and human health 认领 引用 被引量：5
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作者 Nan Chai Jie Xu +12 位作者 Ruixiang Zhang Guangzhou Li Jun Wen Liying Su Yang Xue Tie Li Jialin Liu Dongchang Zeng Jiantao Tan Jiaqi Huang Letian Chen Yao-Guang Liu Qinlong Zhu 《The Crop Journal》 SCIE CSCD 2026年第1期8-21,共14页
A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synth... A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synthetic metabolic engineering offers a method to modify and redesign metabolic pathways to increase the nutritional value of crops.We summarize recent advances in the biofortification of key nutrients including provitamin A,vitamin C,vitamin B9,iron,zinc,anthocyanins,flavonoids,and unsaturated fatty acids.We discuss the potential of multi-gene stacking,gene editing,enzyme engineering,and artificial intelligence in synthetic metabolic engineering.We propose future research directions and potential solutions centered on leveraging AI-driven systems biology,precision gene editing,enzyme engineering,agrobacterium-mediated genotype-independent transformation,and modular metabolic engineering strategies to develop next-generation nutritionally enhanced super crops and transform global food systems. 展开更多
关键词 Synthetic biology Synthetic metabolism engineering Functional crops Multigene stacking and gene editing Artificial intelligence
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Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury 认领 引用 被引量：4
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作者 Fanzhuo Zeng Yuxin Li +6 位作者 Xiaoyu Li Xinyang Gu Yue Cao Shuai Cheng He Tian Rongcheng Mei Xifan Mei 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期365-376,共12页
Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in s... Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in spinal cord injury.Previous studies have shown that microglia can promote neuronal survival by phagocytosing dead cells and debris and by releasing neuroprotective and anti-inflammatory factors.However,excessive activation of microglia can lead to persistent inflammation and contribute to the formation of glial scars,which hinder axonal regeneration.Despite this,the precise role and mechanisms of microglia during the acute phase of spinal cord injury remain controversial and poorly understood.To elucidate the role of microglia in spinal cord injury,we employed the colony-stimulating factor 1 receptor inhibitor PLX5622 to deplete microglia.We observed that sustained depletion of microglia resulted in an expansion of the lesion area,downregulation of brain-derived neurotrophic factor,and impaired functional recovery after spinal cord injury.Next,we generated a transgenic mouse line with conditional overexpression of brain-derived neurotrophic factor specifically in microglia.We found that brain-derived neurotrophic factor overexpression in microglia increased angiogenesis and blood flow following spinal cord injury and facilitated the recovery of hindlimb motor function.Additionally,brain-derived neurotrophic factor overexpression in microglia reduced inflammation and neuronal apoptosis during the acute phase of spinal cord injury.Furthermore,through using specific transgenic mouse lines,TMEM119,and the colony-stimulating factor 1 receptor inhibitor PLX73086,we demonstrated that the neuroprotective effects were predominantly due to brain-derived neurotrophic factor overexpression in microglia rather than macrophages.In conclusion,our findings suggest the critical role of microglia in the formation of protective glial scars.Depleting microglia is detrimental to recovery of spinal cord injury,whereas targeting brain-derived neurotrophic factor overexpression in microglia represents a promising and novel therapeutic strategy to enhance motor function recovery in patients with spinal cord injury. 展开更多
关键词 angiogenesis apoptosis brain-derived neurotrophic factor colony stimulating factor 1 receptor inflammation microglia motor function spinal cord injury vascular endothelial growth factor
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Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes 认领 引用 被引量：4
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作者 Yu-Qi Shao Yong-Chen Wang +6 位作者 Lu Wang Hang-Ze Ruan Yun-Feng Liu Ti-Hui Zhang Shi-Jun Weng Xiong-Li Yang Yong-Mei Zhong 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期800-810,共11页
Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission ... Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission are associated with pathophysiological and neurodegenerative disorders,whereas glucagon-like peptide-1 has demonstrated neuroprotective effects.However,it is not yet clear whether diabetes causes alterations in inhibitory input to retinal ganglion cells and whether and how glucagon-like peptide-1 protects against neurodegeneration in the diabetic retina through regulating inhibitory synaptic transmission to retinal ganglion cells.In the present study,we used the patch-clamp technique to recordγ-aminobutyric acid subtype A receptor-mediated miniature inhibitory postsynaptic currents in retinal ganglion cells from streptozotocin-induced diabetes model rats.We found that early diabetes(4 weeks of hyperglycemia)decreased the frequency of GABAergic miniature inhibitory postsynaptic currents in retinal ganglion cells without altering their amplitude,suggesting a reduction in the spontaneous release ofγ-aminobutyric acid to retinal ganglion cells.Topical administration of glucagon-like peptide-1 eyedrops over a period of 2 weeks effectively countered the hyperglycemia-induced downregulation of GABAergic mIPSC frequency,subsequently enhancing the survival of retinal ganglion cells.Concurrently,the protective effects of glucagon-like peptide-1 on retinal ganglion cells in diabetic rats were eliminated by topical administration of exendin-9-39,a specific glucagon-like peptide-1 receptor antagonist,or SR95531,a specific antagonist of theγ-aminobutyric acid subtype A receptor.Furthermore,extracellular perfusion of glucagon-like peptide-1 was found to elevate the frequencies of GABAergic miniature inhibitory postsynaptic currents in both ON-and OFF-type retinal ganglion cells.This elevation was shown to be mediated by activation of the phosphatidylinositol-phospholipase C/inositol 1,4,5-trisphosphate receptor/Ca2+/protein kinase C signaling pathway downstream of glucagon-like peptide-1 receptor activation.Moreover,multielectrode array recordings revealed that glucagon-like peptide-1 functionally augmented the photoresponses of ON-type retinal ganglion cells.Optomotor response tests demonstrated that diabetic rats exhibited reductions in visual acuity and contrast sensitivity that were significantly ameliorated by topical administration of glucagon-like peptide-1.These results suggest that glucagon-like peptide-1 facilitates the release ofγ-aminobutyric acid onto retinal ganglion cells through the activation of glucagon-like peptide-1 receptor,leading to the de-excitation of retinal ganglion cell circuits and the inhibition of excitotoxic processes associated with diabetic retinopathy.Collectively,our findings indicate that theγ-aminobutyric acid system has potential as a therapeutic target for mitigating early-stage diabetic retinopathy.Furthermore,the topical administration of glucagon-like peptide-1 eyedrops represents a non-invasive and effective treatment approach for managing early-stage diabetic retinopathy. 展开更多
关键词 diabetic retinopathy glucagon-like peptide-1 inhibitory synaptic transmission miniature inhibitory postsynaptic currents neurodegeneration neuroprotection patch-clamp recording protein kinase C signaling pathway visual function
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Supramolecular self-assembled graphitic carbon nitride catalyst:A comprehensive review on design principle,synthesis strategy,functionalization and application 认领 引用 被引量：2
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作者 Hao Yang Shaodong Sun +1 位作者 Qing Yang Jie Cui 《Nano Materials Science》 EI CAS CSCD 2026年第2期364-437,共74页
Graphitic carbon nitride(g-CN)stands out as the most promising candidate for solar energy conversion owing to its easy preparation,metal-free nature,flexible molecular structure,moderate bandgap,and excellent thermal/... Graphitic carbon nitride(g-CN)stands out as the most promising candidate for solar energy conversion owing to its easy preparation,metal-free nature,flexible molecular structure,moderate bandgap,and excellent thermal/chemical stability.To enhance the performance of intrinsic g-CN,a supramolecular self-assembly strategy has been proposed to regulate the molecular structure of supramolecular precursors through non-covalent interactions across molecular building blocks,thereby optimizing the electronic structure of g-CN.This review provides a comprehensive overview of the recent progress in supramolecular self-assembly-derived graphitic carbon nitride(SM-CN)from both experimental and theoretical computational research in synthesis strategies,including synthesis methods and influencing factors,providing a theoretical foundation for the design of supramolecular assembly.It also discusses modification strategies,such as internal modification of the conjugated plane,interlayer optimization,and construction of heterointerfaces to improve the electronic structure of SM-CN owing to its unique layered structure.This review further summarizes the applications of SM-CN in environment and energy,including wastewater treatment,sterilization and disinfection/air purification,water splitting,H2O2production,organic synthesis/biomass conversion,CO2reduction,photocatalytic coupling technology.Finally,perspectives and outlooks for the future development of SM-CN aim to inspire further innovation in the design and construction of high-performance SM-CN for broader applications. 展开更多
关键词 Graphitic carbon nitride Photocatalysis Supramolecular self-assembly Functionalization Application
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Periodontitis pathogen Porphyromonas gingivalis promotes chronic obstructive pulmonary disease via affecting neutrophils chemotaxis and function 认领 引用 被引量：1
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作者 Luyao Zhang Huan Tian +4 位作者 Yuanyuan Ma Jing Xu Chang Guo Zuomin Wang Jie Ma 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第1期115-125,共11页
Chronic obstructive pulmonary disease(COPD),a disease responsible for early mortality worldwide,is well accepted to be associated with periodontitis epidemiologically.Although both of the diseases are the multi-microb... Chronic obstructive pulmonary disease(COPD),a disease responsible for early mortality worldwide,is well accepted to be associated with periodontitis epidemiologically.Although both of the diseases are the multi-microbial inflammatory disease,the precise underlying mechanisms by which periodontitis influences the progression of COPD remains largely unknown.Here,we established COPD accompanied with periodontitis mouse models and observed the pronounced progress in pulmonary symptoms and histopathology,cha racterized by poorer respiratory function,thicke ned bronchial walls,and increased neutrophils infiltration in lung tissue.Mechanistically,periodontitis pathogen Porphyromonas gingivalis(P.gingivalis)relocated in the lung through the respiratory tract and LPS from P.gingivalis promoted the secretion of chemokines CXCL2 and G-CSF of alveolar epithelial cells through NF-κB and p38 MAPK pathways to recruit neutrophils.Furthermore,exposure to P.gingivalis of infiltrated neutrophils released matrix metallopeptidase-8(MMP-8)and neutrophil elastase(NE),which aggravated airway inflammation and tissue damage.These findings indicated that periodontitis could exacerbate COPD via its pathogen P.gingivalis,which translocated in the lung and stimulated neutrophil chemotaxis and activation in the lung. 展开更多
关键词 neutrophils chemotaxis pulmonary symptoms histopathology periodontitis neutrophils function chronic obstructive pulmonary disease respiratory function chronic obstructive pulmonary disease copd
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Functional near-infrared spectroscopy:Systematic mapping of abnormal brain function features in neurological disorders 认领 引用 被引量：1
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作者 Yunjie Li Yangyang Feng +6 位作者 Xia Liu Ruochao Yuan Shiling Chen Jingyi Wang Chao Pan Gaigai Li Zhouping Tang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第10期4506-4522,共17页
Functional near-infrared spectroscopy quantifies cerebral hemodynamic signals by capturing oxygenation-dependent changes in hemoglobin in a noninvasive,portable,and ecologically valid manner,providing a unique insight... Functional near-infrared spectroscopy quantifies cerebral hemodynamic signals by capturing oxygenation-dependent changes in hemoglobin in a noninvasive,portable,and ecologically valid manner,providing a unique insight into neurovascular coupling.However,functional imaging biomarkers with high ecological validity for neurological disorders such as stroke,Parkinson's disease,dementia,amyotrophic lateral sclerosis,epilepsy,spinal cord injury,and traumatic brain injury are lacking,limiting the mechanistic understanding,treatment evaluations,and individualized interventions.The aim of this review is to systematically summarize evidence from the past decade on the use of functional near-infrared spectroscopy under the aforementioned conditions,synthesize its value for revealing neural mechanisms and assessing therapeutic responses,and identify current technical bottlenecks and future directions for advancement.Collectively,the findings demonstrate that functional near-infrared spectroscopy possesses substantial and far-reaching potential for uncovering the neural mechanisms underlying disease and for evaluating treatment-induced changes in brain function.Equipped with wearable probes,functional near-infrared spectroscopy can continuously and noninvasively monitor brain activity in naturalistic environments for extended periods,thereby overcoming the limitations of conventional imaging modalities that can only acquire data under restricted settings.This capability can furnish unprecedented objective neuroimaging evidence for neuroregenerative therapy research.Moreover,the portability of functional near-infrared spectroscopy allows it to be integrated into neurofeedback training systems:hemoglobin signals can be fed back to participants within milliseconds,enabling targeted,individualized,closed-loop modulation of brain function and considerably expanding the scope of hemodynamicsbased neurofeedback.When combined with other brain function assays(such as electroencephalography)and intervention techniques(such as transcranial magnetic stimulation and transcranial direct current stimulation),functional near-infrared spectroscopy also supplies high-temporal-resolution hemodynamic information,laying a critical foundation for the construction of high-precision noninvasive brain–computer interfaces,real-time cognitivestate decoding,and adaptive neuromodulation.Admittedly,almost all existing functional near-infrared spectroscopy studies are still observational and have small sample sizes,short follow-ups,and insufficient controls—shortcomings that together produce low-grade evidence.Therefore,there is still a significant gap before clinical translation can be achieved.Technically,the limited penetration depth of functional near-infrared spectroscopy restricts sampling to the superficial cortex,leaving deep nuclei largely unreachable.In addition,no consensus exists across devices regarding optode layout,light-source choice,motion-artifact correction,or analytical pipelines,creating pronounced heterogeneity that undermines reproducibility.With artificial intelligence and big data analytics advancing rapidly,functional near-infrared spectroscopy embedded within multimodal fusion frameworks is now poised to systematically map aberrant brain function signatures of neurological disorders,identify pathological regions suitable for targeted intervention,and provide real-time assessments of functional changes produced by neuroregenerative therapies. 展开更多
关键词 biomarkers brain mapping clinical translational application functional connectivity functional near-infrared spectroscopy multimodal fusion nervous system diseases neuroimaging neuroregenerative therapy neurovascular coupling
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Ab initio density functional theory approach to warm dense hydrogen:From density response to electronic correlations 认领 引用 被引量：1
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作者 Zhandos A.Moldabekov Xuecheng Shao +5 位作者 Hannah M.Bellenbaum Cheng Ma Wenhui Mi Sebastian Schwalbe Jan Vorberger Tobias Dornheim 《Matter and Radiation at Extremes》 SCIE EI CAS CSCD 2026年第2期14-20,共7页
Understanding the properties of warm dense hydrogen is of key importance for the modeling of compact astrophysical objects and to understand and further optimize inertial confinement fusion applications.The workhorse ... Understanding the properties of warm dense hydrogen is of key importance for the modeling of compact astrophysical objects and to understand and further optimize inertial confinement fusion applications.The workhorse of warm dense matter theory is thermal density functional theory(DFT),which,however,suffers from two limitations:(i)its accuracy can depend on the utilized exchange-correlation functional,which has to be approximated,and(ii)it is generally limited to single-electron properties such as the density distribution.Here,we present a new ansatz combining time-dependent DFT results for the dynamic structure factor See(q,ω)with static DFT results for the density response.This allows us to estimate the electron-electron static structure factor See(q)of warm dense hydrogen with high accuracy over a broad range of densities and temperatures.In addition to its value for the study of warm dense matter,our work opens up new avenues for the future study of electronic correlations exclusively within the framework of DFT for a host of applications. 展开更多
关键词 thermal density functional theory dft whichhoweversuffers understanding properties warm dense hydrogen thermal density functional theory understand further optimize inertial confinement fusion applicationsthe warm dense matter theory electronic correlations warm dense hydrogen density functional theory
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A radiomics approach for predicting gait freezing in Parkinson's disease based on resting-state functional magnetic resonance imaging indices:A cross-sectional study 认领 引用 被引量：3
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作者 Miaoran Guo Hu Liu +6 位作者 Long Gao Hongmei Yu Yan Ren Yingmei Li Huaguang Yang Chenghao Cao Guoguang Fan 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第4期1621-1627,共7页
Freezing of gait is a significant and debilitating motor symptom often observed in individuals with Parkinson's disease.Resting-state functional magnetic resonance imaging,along with its multi-level feature indice... Freezing of gait is a significant and debilitating motor symptom often observed in individuals with Parkinson's disease.Resting-state functional magnetic resonance imaging,along with its multi-level feature indices,has provided a fresh perspective and valuable insight into the study of freezing of gait in Parkinson's disease.It has been revealed that Parkinson's disease is accompanied by widespread irregularities in inherent brain network activity.However,the effective integration of the multi-level indices of resting-state functional magnetic resonance imaging into clinical settings for the diagnosis of freezing of gait in Parkinson's disease remains a challenge.Although previous studies have demonstrated that radiomics can extract optimal features as biomarkers to identify or predict diseases,a knowledge gap still exists in the field of freezing of gait in Parkinson's disease.This cross-sectional study aimed to evaluate the ability of radiomics features based on multi-level indices of resting-state functional magnetic resonance imaging,along with clinical features,to distinguish between Parkinson's disease patients with and without freezing of gait.We recruited 28 patients with Parkinson's disease who had freezing of gait(15 men and 13 women,average age 63 years)and 30 patients with Parkinson's disease who had no freezing of gait(16 men and 14 women,average age 64 years).Magnetic resonance imaging scans were obtained using a 3.0T scanner to extract the mean amplitude of low-frequency fluctuations,mean regional homogeneity,and degree centrality.Neurological and clinical characteristics were also evaluated.We used the least absolute shrinkage and selection operator algorithm to extract features and established feedforward neural network models based solely on resting-state functional magnetic resonance imaging indicators.We then performed predictive analysis of three distinct groups based on resting-state functional magnetic resonance imaging indicators indicators combined with clinical features.Subsequently,we conducted 100 additional five-fold cross-validations to determine the most effective model for each classification task and evaluated the performance of the model using the area under the receiver operating characteristic curve.The results showed that when differentiating patients with Parkinson's disease who had freezing of gait from those who did not have freezing of gait,or from healthy controls,the models using only the mean regional homogeneity values achieved the highest area under the receiver operating characteristic curve values of 0.750(with an accuracy of 70.9%)and 0.759(with an accuracy of 65.3%),respectively.When classifying patients with Parkinson's disease who had freezing of gait from those who had no freezing of gait,the model using the mean amplitude of low-frequency fluctuation values combined with two clinical features achieved the highest area under the receiver operating characteristic curve of 0.847(with an accuracy of 74.3%).The most significant features for patients with Parkinson's disease who had freezing of gait were amplitude of low-frequency fluctuation alterations in the left parahippocampal gyrus and two clinical characteristics:Montreal Cognitive Assessment and Hamilton Depression Scale scores.Our findings suggest that radiomics features derived from resting-state functional magnetic resonance imaging indices and clinical information can serve as valuable indices for the identification of freezing of gait in Parkinson's disease. 展开更多
关键词 amplitude of low-frequency fluctuation degree centrality feedforward neural network freezing of gait machine learning parahippocampal gyrus Parkinson's disease receiver operating characteristic regional homogeneity resting-state functional magnetic resonance imaging
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Interfacial plugging of shale microfractures using functionalized graphene oxide with high dispersion stability under harsh conditions 认领 引用 被引量：1
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作者 Dao-Xiong Li Yang Bai +5 位作者 Cheng Wang Na Su Ling-Feng Wu Deng Gu Yu-Fen Zhai Ping-Ya Luo 《Petroleum Science》 SCIE EI CAS CSCD 2026年第1期422-433,共12页
Shale gas development often suffers from wellbore instability due to microfractures in the formation,posing serious challenges to drilling safety and efficiency.This study presents a functionalized graphene oxide(GO-P... Shale gas development often suffers from wellbore instability due to microfractures in the formation,posing serious challenges to drilling safety and efficiency.This study presents a functionalized graphene oxide(GO-PAA)nanomaterial,prepared by grafting hydrophilic polyacrylic acid(PAA)chains onto GO surfaces to enhance dispersion stability under high salinity,elevated temperature,and wide pH conditions.The results indicate that GO-PAA effectively resists charge-shielding effects under conditions of high salinity,elevated temperature,and a wide pH range,significantly reducing the risk of particle aggregation.Even at high salt concentrations,the zeta potential remains below-32.8 mV,demonstrating good colloidal stability.Plugging performance was evaluated using simulated core experiments.GO-PAA fo rmed a"band-aid"like barrier on shale microfracture surfaces,reducing permeability by up to57.53%,nearly twice that of conventional spherical nano particles.Scanning electron microscope(SEM)and elemental analysis confirmed the formation of a dense and uniform plugging layer.The synergistic interaction between GO's 2D lamellar structure and the flexible polymer chains facilitated effective surface adhesion and coverage.This adsorption-adhesion plugging mechanism represents a shift from traditional bridging theories,enabling reduced material usage and improved efficiency.The findings provide theo retical and practical support for designing high-perfo rmance nanoplugging agents in waterbased drilling fluids,contributing to safer and more sustainable shale gas development. 展开更多
关键词 Functionalized GO Stable dispersion Interfacial plugging Nanoplugging agent Shale microfractures
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Influence of aerobic exercise on the cognitive and social functions of elderly patients with schizophrenia 认领 引用 被引量：1
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作者 Can Ao Lu Zhan +2 位作者 Yu-Lan Mou Shu Hu Yong-Hong Huang 《World Journal of Psychiatry》 SCIE 2026年第3期180-190,共11页
BACKGROUND Schizophrenia presents complex challenges in older patients due to cognitive and social decline.Existing drug treatments offer limited benefits and pose risks,while aerobic exercise shows promise as a nonin... BACKGROUND Schizophrenia presents complex challenges in older patients due to cognitive and social decline.Existing drug treatments offer limited benefits and pose risks,while aerobic exercise shows promise as a noninvasive intervention whose impact remains underexplored.AIM To investigate the effects of aerobic exercise on cognitive and social function in older patients with schizophrenia.METHODS A retrospective study was conducted in 158 older patients with schizophrenia treated at The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College(June 2023 and December 2024).The patients were divided into an observation group(n=86),which received 3 months of aerobic rehabilitation alongside routine treatment,and a control group(n=72),which received routine treatment alone.Cognitive function was assessed using the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery,social function using the Inpatient Psychiatric Rehabilitation Outcome Scale(IPROS),and psychotic symptoms using the Positive and Negative Syndrome Scale.RESULTS Post-treatment,Positive and Negative Syndrome Scale total scores were lower in the observation group than in the controls(P<0.001),with significant improvements in positive,negative,and general symptoms.Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery domain scores were improved in processing speed,working memory,verbal/visual learning,and executive function(all P<0.05).IPROS total scores were decreased(P<0.001),indicating better social functioning.Longer exercise duration correlated with greater cognitive gains and lower social function deficits.Body mass index declined(P<0.001),and adverse events were mild and transient(9.3%).Multivariate linear regression confirmed that aerobic exercise was independently associated with a significant reduction in IPROS scores(Adjustedβ=-4.57,95%confidence intervals:-6.08 to-3.05,P<0.001).CONCLUSION Aerobic exercise effectively improves cognitive function,social function,and psychotic symptoms in older patients with schizophrenia,is safe,and serves as a valuable adjunctive intervention. 展开更多
关键词 Schizophrenia Aerobic exercise Cognitive function Social function Elderly patients
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Kinetically controlled Np(Ⅵ)/Pu(Ⅳ) selective reduction by n-butyraldehyde 认领 引用 被引量：1
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作者 Xiaobo Li Qunyan Wu +3 位作者 Congzhi Wang Jianhui Lan Meng Zhang Weiqun Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第2期430-436,共7页
The demand for 238Pu (nuclear battery heat source) drives the separation of its precursor,237Np,from spent nuclear fuel (SNF).However,the co-existence of multi-valence states (Ⅳ/Ⅴ/Ⅵ) of Np and similar redox b... The demand for 238Pu (nuclear battery heat source) drives the separation of its precursor,237Np,from spent nuclear fuel (SNF).However,the co-existence of multi-valence states (Ⅳ/Ⅴ/Ⅵ) of Np and similar redox behavior with Pu(Ⅳ) hinder the effective separation of Np.N-Butyraldehyde (n-C3H7CHO) selectively reduces Np(Ⅵ) to Np(Ⅴ) without reducing Pu(Ⅳ).Herein,we examined the reduction mechanisms of Np(Ⅵ) and Pu(Ⅳ) by n-C3H7CHO using relativistic density functional theory.Based on the results of the potential energy profiles,the reductions of both Np(Ⅵ) and Pu(Ⅳ) by n-C3H7CHO are thermodynamically feasible,whereas only the former is kinetically achievable.It uncovers that n-C3H7CHO can only reduce Np(Ⅵ) to Np(Ⅴ) owing to kinetically controlled selective reduction.The analyses of spin density and bond distance indicate that the reduction nature for the first Np(Ⅵ)/Pu(Ⅳ) belongs to hydrogen atom transfer,whereas that for the second one involves outer-sphere electron transfer.Localized molecular orbitals (LMOs) analysis discloses the bonding evolution during the reduction process of Np(Ⅵ)/Pu(Ⅳ).This study elucidates the reason behind the kinetically controlled selective reduction of Np(Ⅵ)/Pu(Ⅳ) by nC3H7CHO at the molecular level and offers in-depth perspectives on the isolation of specific metal ions from the view of kinetic control. 展开更多
关键词 Neptunium Plutonium Reduction Density functional theory Kinetic control
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Dietary supplementation with sodium isobutyrate enhances growth performance and colonic barrier function in weaned piglets via microbiota-metabolite-host interactions 认领 引用 被引量：1
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作者 Xiuyu Fang Zihan Chi +6 位作者 Zhengyi Wang Xinlin Wang Xingrui Qu Shuang Zhang Feng Gao Baoming Shi Xuan Zhao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第1期404-425,共22页
Background Weaning-induced diarrhoea and growth retardation in piglets are associated with impaired intestinal barrier function and decreased levels of colonic short-chain fatty acids(SCFAs).Although SCFA supplementat... Background Weaning-induced diarrhoea and growth retardation in piglets are associated with impaired intestinal barrier function and decreased levels of colonic short-chain fatty acids(SCFAs).Although SCFA supplementation has been proposed to mitigate these issues,the efficacy and optimal dosage of sodium isobutyrate remain unclear.Results We investigated the effects of sodium isobutyrate supplementation(500,1,000,2,000,and 4,000 mg/kg diet)on weaned piglets(Duroc×Landrace×Yorkshire,28 d of age;n=8).After a 28-d feeding trial,supplementation at 500–2,000 mg/kg significantly improved average daily gain and feed efficiency and reduced diarrhoea frequency,with maximal benefits observed at 1,000 mg/kg(P<0.0001).Additionally,500–1,000 mg/kg sodium isobutyrate supplementation increased the apparent digestibility of crude protein,organic matter,and crude fibre(P<0.05).Serum biochemical parameters were unaffected,although secretory immunoglobulin A(SIgA)levels significantly increased upon supplementation with 500–1,000 mg/kg(P<0.05).16S rRNA gene sequencing indicated that sodium isobutyrate increased the abundance of beneficial colonic microbiota.The 1,000 mg/kg group presented the most pronounced effect,with a significant increase of the relative abundance of Prevotella and the greatest improvement in SCFA concentrations(P<0.05).Metabolomics revealed elevated levels of colonic indole-3-lactic acid and 3-hydroxybutyrate upon supplementation with 1,000 mg/kg(P<0.05).Transcriptomic analyses indicated activation of protein digestion and absorption pathways,and PI3K-Akt signalling,marked by TSG-6 upregulation and the suppression of ISG15 and DDIT4 expression(P<0.05).Supplementation with 1,000 mg/kg was associated with improved intestinal barrier-related markers,including reduced serum D-lactate,diamine oxidase,and lipopolysaccharide levels,increased tight junction protein expression;activation of G protein-coupled receptors;and inhibition of TLR4/MyD88/NF-κB signalling(P<0.05),suggesting enhanced barrier function.Conclusions In conclusion,dietary supplementation with 1,000 mg/kg sodium isobutyrate was associated with improved intestinal morphology,reduced serum permeability,increased expression of tight junction proteins,and enhanced immune function in weaned piglets,suggesting enhanced colonic barrier function and providing dosage guidance and mechanistic insights for future applications. 展开更多
关键词 Colonic barrier function Diarrhoea Intestinal microbiota Sodium isobutyrate Weaned piglets
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New functional metal-organic framework(MOF) based optical thermometer by the post-synthesis doping rare earth ions into MOF 认领 引用 被引量：1
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作者 Ying Zhao Yin-Hang Chai +4 位作者 Meng-Meng Zhai Qin-Ying Jin Xiaoyan Lu Yi-Dan Qiao Lu-Fang Ma 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第1期644-649,共6页
Ln@MOFs by anchoring rare metal ions(Ln) into metal-organic frameworks(MOFs) are proved to have great potential in the field of luminescent molecular thermometer.Nevertheless,the current research indicated that the po... Ln@MOFs by anchoring rare metal ions(Ln) into metal-organic frameworks(MOFs) are proved to have great potential in the field of luminescent molecular thermometer.Nevertheless,the current research indicated that the poor structural stability and low sensitivity hindered their application scope.In this work,a new MOF Zn-450 luminescent thermometer with multiple emission fluorescence characteristics was synthesized by the combination of 3,3,5,5-biphenyl tetracarboxylic acid(H4L) and Zn2+ ion under solvothermal conditions.Interestingly,a high relative sensitivity of 1.43 % K-1 was found within 80-300 K based on Zn-450.Subsequently,two high-sensitivity luminescent Ln@MOFs(Ln = Eu and Tb) were further fabricated by doping rare earth ions into Zn-450 based on the post-synthesis strategy.Among them,the Eu@Zn-450 demonstrates various luminous behaviors while achieving an increased relative sensitivity of 1.63 % K-1.In addition,the continuously visible red,pink,and purple luminescent emissions at the same temperature range were observed,suggesting that the Eu@Zn-450 could be utilized as a luminescent colorimetric molecular thermometer.Importantly,this work can present new possibilities for the development of rare earth-doped luminescence and its temperature sensing properties. 展开更多
关键词 MOFs Optical thermometer Post-synthesis functionalization Rare metal ions LED
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Definition of critical skin defect and concepts of structural and functional repairs:Proposal and verification in a rat model 认领 引用 被引量：1
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作者 Cong Sun Weihong Guo +4 位作者 Fang Liang Rabia Javed Weijian Hou Xingdong Zhang Qiang Ao 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第1期168-182,共15页
Background:Rats are often used to prepare skin defect models.However,the skin defect sizes of the models prepared by researchers are different,and the lack of consensus on the critical-size defect makes it difficult t... Background:Rats are often used to prepare skin defect models.However,the skin defect sizes of the models prepared by researchers are different,and the lack of consensus on the critical-size defect makes it difficult to compare their research results.Methods:The time for wound closure was evaluated and recorded through gross observation.The regression equation between the healing time and the diameter of skin defect was established,which can be used to predict the healing time for a certain skin defect size in rats.Histochemical and immunohistochemical staining was used to observe the regeneration and reconstruction of skin appendages,and the functional skin repair was quantitatively scored.Results:The critical-size defect of rats was determined based on the maximum capacity of structural skin repair,and the functional skin repair was quantitatively scored based on the regeneration and reconstruction of skin appendages.The allowable range of critical-size skin defect of SD rats lies between 45 and 50 mm in diameter.The concept of structural repair and the category of functional repair of injured skin are put forward.The regression equation between the structural skin healing time and defect diameters is established.Conclusion:The allowable range of skin critical-size defect of SD rats lies between 45 and 50 mm in diameter.The regression equation between the structural skin healing time and defect diameters can be used to predict the healing time for a certain skin defect size in rats. 展开更多
关键词 critical defect functional repair quantitative evaluation skin defect structural repair
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Genome-wide association study of HBV-related hepatocellular carcinoma identifies a functional variant at the FAM114A1 locus 认领 引用 被引量：1
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作者 Hong-Ping Yu Bang-De Xiang +29 位作者 Ji Qian Hongliang Liu Yuan-Feng Li Qiuling Lin Shun Liu Junjie Wei Shicheng Zhan Binbin Jiang Juncheng Dai Liang Ma Litu Zhang Yingchun Liu Qiuping Wen Wenfeng Gong Shengping Li Yanji Jiang Ji Zheng Tianyi Zhu Zihan Zhou Xiaoyun Zeng Ziliang Wang Ji-Ao Wang Rui Guo Yuan Yang Qingyi Wei Gangqiao Zhou Xiao-Qiang Qiu Weizhong Tang Mengyun Wang Ruoxin Zhang 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第4期643-654,共12页
Liver cancer ranks sixth in cancer incidence and third in cancer-related deaths worldwide.Hepatocellular carcinoma(HCC)is the primary histological subtype,and hepatitis B virus(HBV)carriers have a higher risk of HCC.A... Liver cancer ranks sixth in cancer incidence and third in cancer-related deaths worldwide.Hepatocellular carcinoma(HCC)is the primary histological subtype,and hepatitis B virus(HBV)carriers have a higher risk of HCC.Although several susceptibility loci for HCC have been identified in East Asian populations through genome-wide association studies(GWAS),the underlying biological mechanisms of this malignancy remain incompletely understood.Here,we conduct a two-stage GWAS including 2413 cases and 2794 HBV-positive controls from a high-incidence region in Southern China.The function of the susceptibility locus is investigated by bioinformatic and experimental approaches,supported by a xenograft model.We identify a 4p14 locus significantly associated with the risk of HCC(rs55718051,OR[95%CI]=0.73[0.67-0.80],Pmeta=9.14×10-11),and 18q23 locus with borderline significance(rs12964643:OR[95%CI]=0.75[0.67-0.83],Pmeta=1.11×10-7).Functional experiments indicate the role of rs55718051 in FAM114A1 expression regulation,possibly through the interaction with FOXA1.Knockdown of FAM114A1 significantly promote the oncogenic phenotypes in liver cancer cells,suggesting its potential tumor suppressor role.Our findings expand the understanding of HCC susceptibility and suggest FAM114A1 as a potential suppressor in HBV-related HCC carcinogenesis. 展开更多
关键词 Hepatocellular carcinoma Hepatitis B virus Genome-wide association study Functional variant Cancer susceptibility
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Performance-based comprehensive functional damage probability assessment framework for high-speed railway bridge under earthquake 认领 引用 被引量：1
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作者 Gaoyang Zhou Zhihui Zhu +1 位作者 Weiqi Zheng Yongjiu Tang 《Railway Engineering Science》 EI 2026年第2期201-216,共16页
Current seismic damage assessments for high-speed railway(HSR)bridges primarily focus on the overall structural safety,lacking evaluations from multiple performance perspectives,which affects the post-earthquake traff... Current seismic damage assessments for high-speed railway(HSR)bridges primarily focus on the overall structural safety,lacking evaluations from multiple performance perspectives,which affects the post-earthquake traffic decision-making for the bridges.This study proposes a performance-based comprehensive functional damage probability assessment framework for high-speed railway simply supported bridges(HSRSSBs)under earthquakes.The framework categorizes the functions of HSR bridges into three levels:post-earthquake traffic function(PTF),structural bearing function(SBF),and collapse resistance function(CRF),corresponding to the operational,structural safety,and structural integrity requirements of HSRSSB,respectively.By analyzing the damage states of key bridge components during earthquakes,the functional damage probability assessment indicators and classification thresholds are established according to various performance requirements.Damage probability calculations are conducted using the probability density evolution method and vulnerability method.Finally,based on the relationship between damage probabilities at different functional levels,a comprehensive damage probability assessment framework considering the three-level performance requirements of HSRSSBs is developed,and the influence of varying pier heights on the functional damage probability relationship is examined.The results indicate that current HSRSSB designs meet all performance requirements under frequent earthquakes.Under design-level earthquake conditions,the SBF remains in a slight damage state,while the PTF exhibits varying degrees of damage,which worsens as pier height increases.The pier structure satisfies seismic demands even under rare earthquake conditions. 展开更多
关键词 Earthquake High-speed railway bridge Damage probability Functional damage Performance-based
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