BACKGROUND Gut microbial dysbiosis is central to the pathogenesis of inflammatory bowel disease(IBD).While gut microbiome differences between patients with and without IBD are well established,microbiome changes assoc...BACKGROUND Gut microbial dysbiosis is central to the pathogenesis of inflammatory bowel disease(IBD).While gut microbiome differences between patients with and without IBD are well established,microbiome changes associated with disease activity and remission remain limited,particularly in paediatric populations.AIM To examine intra-individual taxonomic and functional gut microbiome changes during transition from active flare to remission under maintenance immunosuppression in a pilot single-center Singapore cohort of children with IBD.METHODS Paired stool samples and clinical data were collected from seven patients with paediatric IBD[5 Crohn’s disease(CD),2 ulcerative colitis;≤18 years]during active disease/flare(visit 1;Pediatric CD Activity Index/Pediatric Ulcerative Colitis Activity Index≥10)and subsequent clinical remission(visit 2;Pediatric CD Activity Index/Pediatric Ulcerative Colitis Activity Index<10).Samples underwent shotgun metagenomic sequencing for high-resolution taxonomic profiling and functional annotation of Kyoto Encyclopaedia of Genes and Genomes pathways.RESULTS Gut microbial diversity was reduced during flare compared to remission,with Actinobacteria abundance significantly higher in remission.Two distinct microbial clusters differentiated flare and remission states:The remission cluster was enriched with Bifidobacterium adolescentis,Bifidobacterium dentium,Lactobacillus gasseri,Faecalibacterium prausnitzii,while the flare state showed increased Klebsiella pneumoniae.Remission was further characterized by a downregulation of pathogenic microbes and an upregulation of beneficial microbes including a higher abundance of the butyrate producer Anaerostipes hadrus(P=0.046).Microbial functional genes enriched in remission were predominantly associated with metabolic pathways including vitamin and cofactor biosynthesis,as well as carbohydrate,amino acid,and lipid metabolism.CONCLUSION The transition from flare to remission in Singaporean children with IBD is characterized by functional remodeling of the gut microbiome,which may contribute to recovery processes related to intestinal barrier integrity,cellular maintenance,and tissue repair.Targeted modulation of the gut microbiome may help sustain remission in paediatric IBD.展开更多
In this article, we mainly devote to proving uniqueness results for entire functionssharing one small function CM with their shift and difference operator simultaneously. Letf(z) be a nonconstant entire function of ...In this article, we mainly devote to proving uniqueness results for entire functionssharing one small function CM with their shift and difference operator simultaneously. Letf(z) be a nonconstant entire function of finite order, c be a nonzero finite complex constant, and n be a positive integer. If f(z), f(z+c), and △n cf(z) share 0 CM, then f(z+c)≡Af(z), where A(≠0) is a complex constant. Moreover, let a(z), b(z)( O) ∈ S(f) be periodic entire functions with period c and if f(z) - a(z), f(z + c) - a(z), △cn f(z) - b(z) share 0 CM, then f(z + c) ≡ f(z).展开更多
In this paper, we consider functional operators with shift in weighted H?lder spaces. We present the main idea and the scheme of proof of the conditions of invertibility for these operators. As an application, we prop...In this paper, we consider functional operators with shift in weighted H?lder spaces. We present the main idea and the scheme of proof of the conditions of invertibility for these operators. As an application, we propose to use these results for solution of equations with shift which arise in the study of cyclic models for natural systems with renewable resources.展开更多
Rotation symmetric function was presented by Pieprzyk. The algebraic configuration of rotation symmetric(RotS) function is special. For a Rots n variables function f(x1, x2, …, xn) we have f(ρn^k (x1, x2, …x...Rotation symmetric function was presented by Pieprzyk. The algebraic configuration of rotation symmetric(RotS) function is special. For a Rots n variables function f(x1, x2, …, xn) we have f(ρn^k (x1, x2, …xn))=f(x1, x2, …, xn) for k=0, 1, …, n-1. In this paper, useing probability method we find that when the parameters of RotS function is under circular translation of indices, its walsh spectrum is invariant. And we prove the result is both sufficient and necessary.展开更多
Mean Shift是一种基于特征的对目标实现快速跟踪的算法,传统的Mean Shift算法由于跟踪中物体的尺度变化会使跟踪偏离目标乃至跟踪失败,并且原有的自适应地对跟踪窗宽的调整,是基于对核窗宽的改变来得到的。在"固定跟踪窗宽—改变...Mean Shift是一种基于特征的对目标实现快速跟踪的算法,传统的Mean Shift算法由于跟踪中物体的尺度变化会使跟踪偏离目标乃至跟踪失败,并且原有的自适应地对跟踪窗宽的调整,是基于对核窗宽的改变来得到的。在"固定跟踪窗宽—改变核窗宽"的基础上对目标进行跟踪,对目标空间定位精度进行了评估与分析,通过实验结果表明改变核函数参数能改善目标跟踪的精度。展开更多
基金Supported by the Exxon-Mobil National University Singapore Research Fellowship for Clinicians.
摘要BACKGROUND Gut microbial dysbiosis is central to the pathogenesis of inflammatory bowel disease(IBD).While gut microbiome differences between patients with and without IBD are well established,microbiome changes associated with disease activity and remission remain limited,particularly in paediatric populations.AIM To examine intra-individual taxonomic and functional gut microbiome changes during transition from active flare to remission under maintenance immunosuppression in a pilot single-center Singapore cohort of children with IBD.METHODS Paired stool samples and clinical data were collected from seven patients with paediatric IBD[5 Crohn’s disease(CD),2 ulcerative colitis;≤18 years]during active disease/flare(visit 1;Pediatric CD Activity Index/Pediatric Ulcerative Colitis Activity Index≥10)and subsequent clinical remission(visit 2;Pediatric CD Activity Index/Pediatric Ulcerative Colitis Activity Index<10).Samples underwent shotgun metagenomic sequencing for high-resolution taxonomic profiling and functional annotation of Kyoto Encyclopaedia of Genes and Genomes pathways.RESULTS Gut microbial diversity was reduced during flare compared to remission,with Actinobacteria abundance significantly higher in remission.Two distinct microbial clusters differentiated flare and remission states:The remission cluster was enriched with Bifidobacterium adolescentis,Bifidobacterium dentium,Lactobacillus gasseri,Faecalibacterium prausnitzii,while the flare state showed increased Klebsiella pneumoniae.Remission was further characterized by a downregulation of pathogenic microbes and an upregulation of beneficial microbes including a higher abundance of the butyrate producer Anaerostipes hadrus(P=0.046).Microbial functional genes enriched in remission were predominantly associated with metabolic pathways including vitamin and cofactor biosynthesis,as well as carbohydrate,amino acid,and lipid metabolism.CONCLUSION The transition from flare to remission in Singaporean children with IBD is characterized by functional remodeling of the gut microbiome,which may contribute to recovery processes related to intestinal barrier integrity,cellular maintenance,and tissue repair.Targeted modulation of the gut microbiome may help sustain remission in paediatric IBD.
基金supported by the Natural Science Foundation of Guangdong Province in China(2014A030313422,2016A030310106,2016A030313745)
摘要In this article, we mainly devote to proving uniqueness results for entire functionssharing one small function CM with their shift and difference operator simultaneously. Letf(z) be a nonconstant entire function of finite order, c be a nonzero finite complex constant, and n be a positive integer. If f(z), f(z+c), and △n cf(z) share 0 CM, then f(z+c)≡Af(z), where A(≠0) is a complex constant. Moreover, let a(z), b(z)( O) ∈ S(f) be periodic entire functions with period c and if f(z) - a(z), f(z + c) - a(z), △cn f(z) - b(z) share 0 CM, then f(z + c) ≡ f(z).
摘要In this paper, we consider functional operators with shift in weighted H?lder spaces. We present the main idea and the scheme of proof of the conditions of invertibility for these operators. As an application, we propose to use these results for solution of equations with shift which arise in the study of cyclic models for natural systems with renewable resources.
基金Supported by the National Natural ScienceFoundation of China (90104035)
摘要Rotation symmetric function was presented by Pieprzyk. The algebraic configuration of rotation symmetric(RotS) function is special. For a Rots n variables function f(x1, x2, …, xn) we have f(ρn^k (x1, x2, …xn))=f(x1, x2, …, xn) for k=0, 1, …, n-1. In this paper, useing probability method we find that when the parameters of RotS function is under circular translation of indices, its walsh spectrum is invariant. And we prove the result is both sufficient and necessary.