Understanding the properties of warm dense hydrogen is of key importance for the modeling of compact astrophysical objects and to understand and further optimize inertial confinement fusion applications.The workhorse ...Understanding the properties of warm dense hydrogen is of key importance for the modeling of compact astrophysical objects and to understand and further optimize inertial confinement fusion applications.The workhorse of warm dense matter theory is thermal density functional theory(DFT),which,however,suffers from two limitations:(i)its accuracy can depend on the utilized exchange-correlation functional,which has to be approximated,and(ii)it is generally limited to single-electron properties such as the density distribution.Here,we present a new ansatz combining time-dependent DFT results for the dynamic structure factor See(q,ω)with static DFT results for the density response.This allows us to estimate the electron-electron static structure factor See(q)of warm dense hydrogen with high accuracy over a broad range of densities and temperatures.In addition to its value for the study of warm dense matter,our work opens up new avenues for the future study of electronic correlations exclusively within the framework of DFT for a host of applications.展开更多
BACKGROUND Schizophrenia presents complex challenges in older patients due to cognitive and social decline.Existing drug treatments offer limited benefits and pose risks,while aerobic exercise shows promise as a nonin...BACKGROUND Schizophrenia presents complex challenges in older patients due to cognitive and social decline.Existing drug treatments offer limited benefits and pose risks,while aerobic exercise shows promise as a noninvasive intervention whose impact remains underexplored.AIM To investigate the effects of aerobic exercise on cognitive and social function in older patients with schizophrenia.METHODS A retrospective study was conducted in 158 older patients with schizophrenia treated at The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College(June 2023 and December 2024).The patients were divided into an observation group(n=86),which received 3 months of aerobic rehabilitation alongside routine treatment,and a control group(n=72),which received routine treatment alone.Cognitive function was assessed using the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery,social function using the Inpatient Psychiatric Rehabilitation Outcome Scale(IPROS),and psychotic symptoms using the Positive and Negative Syndrome Scale.RESULTS Post-treatment,Positive and Negative Syndrome Scale total scores were lower in the observation group than in the controls(P<0.001),with significant improvements in positive,negative,and general symptoms.Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery domain scores were improved in processing speed,working memory,verbal/visual learning,and executive function(all P<0.05).IPROS total scores were decreased(P<0.001),indicating better social functioning.Longer exercise duration correlated with greater cognitive gains and lower social function deficits.Body mass index declined(P<0.001),and adverse events were mild and transient(9.3%).Multivariate linear regression confirmed that aerobic exercise was independently associated with a significant reduction in IPROS scores(Adjustedβ=-4.57,95%confidence intervals:-6.08 to-3.05,P<0.001).CONCLUSION Aerobic exercise effectively improves cognitive function,social function,and psychotic symptoms in older patients with schizophrenia,is safe,and serves as a valuable adjunctive intervention.展开更多
Chronic obstructive pulmonary disease(COPD),a disease responsible for early mortality worldwide,is well accepted to be associated with periodontitis epidemiologically.Although both of the diseases are the multi-microb...Chronic obstructive pulmonary disease(COPD),a disease responsible for early mortality worldwide,is well accepted to be associated with periodontitis epidemiologically.Although both of the diseases are the multi-microbial inflammatory disease,the precise underlying mechanisms by which periodontitis influences the progression of COPD remains largely unknown.Here,we established COPD accompanied with periodontitis mouse models and observed the pronounced progress in pulmonary symptoms and histopathology,cha racterized by poorer respiratory function,thicke ned bronchial walls,and increased neutrophils infiltration in lung tissue.Mechanistically,periodontitis pathogen Porphyromonas gingivalis(P.gingivalis)relocated in the lung through the respiratory tract and LPS from P.gingivalis promoted the secretion of chemokines CXCL2 and G-CSF of alveolar epithelial cells through NF-κB and p38 MAPK pathways to recruit neutrophils.Furthermore,exposure to P.gingivalis of infiltrated neutrophils released matrix metallopeptidase-8(MMP-8)and neutrophil elastase(NE),which aggravated airway inflammation and tissue damage.These findings indicated that periodontitis could exacerbate COPD via its pathogen P.gingivalis,which translocated in the lung and stimulated neutrophil chemotaxis and activation in the lung.展开更多
Functional near-infrared spectroscopy quantifies cerebral hemodynamic signals by capturing oxygenation-dependent changes in hemoglobin in a noninvasive,portable,and ecologically valid manner,providing a unique insight...Functional near-infrared spectroscopy quantifies cerebral hemodynamic signals by capturing oxygenation-dependent changes in hemoglobin in a noninvasive,portable,and ecologically valid manner,providing a unique insight into neurovascular coupling.However,functional imaging biomarkers with high ecological validity for neurological disorders such as stroke,Parkinson's disease,dementia,amyotrophic lateral sclerosis,epilepsy,spinal cord injury,and traumatic brain injury are lacking,limiting the mechanistic understanding,treatment evaluations,and individualized interventions.The aim of this review is to systematically summarize evidence from the past decade on the use of functional near-infrared spectroscopy under the aforementioned conditions,synthesize its value for revealing neural mechanisms and assessing therapeutic responses,and identify current technical bottlenecks and future directions for advancement.Collectively,the findings demonstrate that functional near-infrared spectroscopy possesses substantial and far-reaching potential for uncovering the neural mechanisms underlying disease and for evaluating treatment-induced changes in brain function.Equipped with wearable probes,functional near-infrared spectroscopy can continuously and noninvasively monitor brain activity in naturalistic environments for extended periods,thereby overcoming the limitations of conventional imaging modalities that can only acquire data under restricted settings.This capability can furnish unprecedented objective neuroimaging evidence for neuroregenerative therapy research.Moreover,the portability of functional near-infrared spectroscopy allows it to be integrated into neurofeedback training systems:hemoglobin signals can be fed back to participants within milliseconds,enabling targeted,individualized,closed-loop modulation of brain function and considerably expanding the scope of hemodynamicsbased neurofeedback.When combined with other brain function assays(such as electroencephalography)and intervention techniques(such as transcranial magnetic stimulation and transcranial direct current stimulation),functional near-infrared spectroscopy also supplies high-temporal-resolution hemodynamic information,laying a critical foundation for the construction of high-precision noninvasive brain–computer interfaces,real-time cognitivestate decoding,and adaptive neuromodulation.Admittedly,almost all existing functional near-infrared spectroscopy studies are still observational and have small sample sizes,short follow-ups,and insufficient controls—shortcomings that together produce low-grade evidence.Therefore,there is still a significant gap before clinical translation can be achieved.Technically,the limited penetration depth of functional near-infrared spectroscopy restricts sampling to the superficial cortex,leaving deep nuclei largely unreachable.In addition,no consensus exists across devices regarding optode layout,light-source choice,motion-artifact correction,or analytical pipelines,creating pronounced heterogeneity that undermines reproducibility.With artificial intelligence and big data analytics advancing rapidly,functional near-infrared spectroscopy embedded within multimodal fusion frameworks is now poised to systematically map aberrant brain function signatures of neurological disorders,identify pathological regions suitable for targeted intervention,and provide real-time assessments of functional changes produced by neuroregenerative therapies.展开更多
BACKGROUND Cognitive impairment is a common functional impairment after stroke that severely affects the quality of life of patients.The underlying neurobiological mechanisms of poststroke cognitive impairment(PSCI)re...BACKGROUND Cognitive impairment is a common functional impairment after stroke that severely affects the quality of life of patients.The underlying neurobiological mechanisms of poststroke cognitive impairment(PSCI)remain unclear.AIM To investigate the changes in functional connectivity(FC)in the brains of patients with PSCI.METHODS A total of 21 patients with PSCI and 12 healthy controls were selected as study subjects,and resting-state functional magnetic resonance imaging was performed.The brain region[Cerebellum_6_R(aal)]with significant differences identified by regional homogeneity analysis and the left thalamus,right thalamus,left basal ganglia,and right basal ganglia in the Brainnetome Atlas were selected as the seeds(regions of interest),and the FC between the seeds and whole-brain voxels was analyzed.Moreover,the 116 brain regions defined in the AAL116 atlas were selected as seeds(regions of interest),and the FC between the whole-brain seeds was calculated.RESULTS The results of the seed-based FC analysis revealed that the FC of the Cerebelum_9_R,Occipital_Mid_L,and Fusiform_R in the PSCI group was significantly greater than that in the control group.FC analysis of whole-brain seeds revealed that the FC of 20 pairs(Cerebelum_4_5_R and Cerebelum_6_R,etc.)in the PSCI group was significantly greater than that in the healthy control group.CONCLUSION Patients with PSCI exhibit changes in the FC of specific brain regions in the resting state,which may help researchers explore the underlying neurobiological mechanisms of PSCI from a new perspective.展开更多
In recent years,researchers have extensively investigated the Hankel determinant,which consists of coefficients appearing in a holomorphic function’s Taylor-Maclaurin series.Hankel matrices are widely used in Markov ...In recent years,researchers have extensively investigated the Hankel determinant,which consists of coefficients appearing in a holomorphic function’s Taylor-Maclaurin series.Hankel matrices are widely used in Markov processes,non-stationary signals,and other mathematical disciplines.The aim of the current research article is to first improve the bounds of coefficient-related problems by employing the well-known Carathéodory function.The problems that we are going to improve were obtained by Tang et al.The sharp estimates of the most difficult problem of geometric function theory known as the third-order Hankel determinant are also contributed here.Zalcman and Fekete-Szegöinequalities are also studied here for the defined family of holomorphic functions.展开更多
Objectives:Mitochondrial function is intricately linked to osteogenic and osteoclastic differentiation.The mitochondrial calcium uniporter(MCU)is a critical regulator of mitochondrial function,influencing key aspects ...Objectives:Mitochondrial function is intricately linked to osteogenic and osteoclastic differentiation.The mitochondrial calcium uniporter(MCU)is a critical regulator of mitochondrial function,influencing key aspects of cellular metabolism and signaling.However,the precise mechanisms by which MCU modulates osteogenic activity remain unclear.This study aimed to elucidate the impact of MCU-mediated regulation of mitochondrial function on bone remodeling and to explore the underlying mechanisms.Methods:The mouse pre-osteoblastic cells(MC3T3-E1)were treated with the MCU-specific inhibitor Ru265 during osteogenic induction to assess changes in osteogenic differentiation capacity,mitochondrial function,and mitochondrial dynamics.Additionally,MCU global knockout(MCU KO)mice were employed as an in vivo model to explore the role of MCU in bone structure phenotype through bone microstructural analysis and histological examination.Results:Quantitative reverse transcription(qRT)PCR,western blotting,alizarin Red-S(ARS)staining,and alkaline phosphatase(ALP)activity analyses revealed that the inhibition of MCU function by Ru265 downregulates ALP activity(about 59.60%of the control group)and the expression of osteogenic markers in MC3T3-E1 cells.Dramatically increased dynamin-related protein 1(Drp1)expression(about 1.13 times of the control group),decreased mitofusion-2(Mfn2)expression(about 14.51%of the control group),and reduced mitochondrial membrane potential(MMP)(about 55.16%of the control group)were observed,all indicating substantial disruption of mitochondrial dynamics and function in MC3T3-E1 cells.The corroborating evidence is thatμCT and histological analyses of MCU global knockout mice revealed impaired osteogenic differentiation,reduced bone mass formation,and deteriorated trabecular bone microstructure compared with wild-type mice.Conclusion:MCU inhibition elicits aberrant mitochondrial dynamics and mitochondrial dysfunction,thereby impairing osteogenic function and disrupting bone remodeling,which could have promising implications for bone metabolism.展开更多
This study proposes a novel method for introducing the concept of umbrella species to identify umbrella ecological functions(UEF).The umbrella ecological function safeguards broader ecological functions within its spa...This study proposes a novel method for introducing the concept of umbrella species to identify umbrella ecological functions(UEF).The umbrella ecological function safeguards broader ecological functions within its spatial extent by protecting a single function.This approach transforms the originally complex ecological function conservation plan into a more specific conservation target,thereby simplifying the conservation process and enhancing conserva-tion practices.Subsequently,this study formulates the ecological function zoning of the Guangdong-Hong Kong-Macao Greater Bay Area of China(GBA)based on the UEF,aiming to provide recommendations for ensuring regional ecological security.The findings reveal that habitat quality(HQ)possesses the highest umbrella value and is therefore deemed suitable as the UEF in the GBA.The ecological function zoning comprises three types of zones:priority conser-vation zone,other conservation zone,and ordinary zone.A critical aspect of protecting the UEF is to limit the encroach-ment of natural ecosystems due to land use changes driven by urbanization.The UEF-based ecological function zoning method established in this study is both universal and widely applicable.However,certain limitations exist.Different UEFs may emerge when the spatial scale of the study object varies.This study posits that the UEF evaluation method is more suitable for applications at a smaller spatial scale,particularly in areas with similar natural environments or geo-graphic conditions.For practical applications,it is recommended that the study area be confined to a smaller spatial scale,such as a county or city.展开更多
OBJECTIVE:To investigate the effects of electroacupuncture intervention on behavioral performance,hippocampal structure,and function in chronic fatigue syndrome(CFS)rats and to explore the underlying mechanisms.METHOD...OBJECTIVE:To investigate the effects of electroacupuncture intervention on behavioral performance,hippocampal structure,and function in chronic fatigue syndrome(CFS)rats and to explore the underlying mechanisms.METHODS:Specific pathogen free-grade male SpragueDawley rats were randomly allocated into a control group(Con group,n=12)and a modeling group.The latter underwent a 21-d CFS induction via an improved chronic multi-factor compound stress stimulation protocol.Successfully modeled CFS rats were then randomly assigned to a model group(Mod group,n=12)and an electroacupuncture group(EA group,n=12).During the 14-d treatment period,both the Mod and EA groups continued to receive chronic stress stimuli.Rats in the EA group received electroacupuncture at Shenting(GV24)through to Baihui(GV20),with additional stimulation on Dazhui(GV14).Each session lasted 15 min,administered twice daily with a 6-h interval between morning and afternoon treatments.After modeling and treatment,the general semi-quantitative score(GSQS)was used to evaluate the rats'general health,while the Morris water maze test(MWMT),open field test(OFT),and exhaustive treadmill test(ETT)were applied to assess their learning/memory,emotional state,and fatigue levels,respectively(n=12 per group).After the treatment phase,cerebral glucose metabolism was assessed by 1fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)imaging(n=3 per group),while hippocampal cornu ammonis 1(CA1)morphology was examined using hematoxylin-eosin(HE)and Nissl staining(n=3 per group).RESULTS:Behavioral assessments demonstrated that electroacupuncture intervention significantly improved rat performance as measured by GSQS,MWMT,OFT,and Exhaustive Treadmill Test.Both HE and Nissl staining results confirmed that,compared with the blank control group,the model group exhibited abnormal cellular morphology,disorganized arrangement,and reduced Nissl bodies in the hippocampal CA1 region.These pathological alterations were ameliorated in the electroacupuncture group relative to the model group.18F-FDG PET/CT imaging revealed that following treatment,the mean and maximum standardized uptake values(SUV)in the anterior-dorsal and posterior hippocampus were significantly decreased in the Mod group compared to the Con group.In contrast,electroacupuncture treatment significantly increased both SUV-mean and SUV-max in these hippocampal subregions in the EA group relative to the Mod group(all P<0.05).CONCLUSION:Electroacupuncture intervention alleviated cognitive impairment,hippocampal pathological structural changes,and glucose metabolism dysfunction in a rat model of chronic fatigue syndrome induced by an improved chronic multi-factor compound stress stimulation method.展开更多
Alzheimer's disease(AD),the most common cause of dementia,is a progressive neurodegenerative disease characterized by progressive cognitive decline and memory loss.Mild cognitive impairment(MCI)is the prodromal st...Alzheimer's disease(AD),the most common cause of dementia,is a progressive neurodegenerative disease characterized by progressive cognitive decline and memory loss.Mild cognitive impairment(MCI)is the prodromal stage of AD,with a conversion rate of 10%-15%per year and 50%conversion rate longitudinally.The pathological features of AD include the aberrant accumulation of amyloid-βplaques,neurofibrillary tangles formed by hyperphosphorylated tau and synaptic dysfunction(Nussbaumer et al.,2025),all of which have cascading effects on the brain activity of AD patients.展开更多
Graphitic carbon nitride(g-C3N4)doped with 3d transition metals(3d-TM@g-C3N4)has gained attention as a noble metal-free alternative for oxygen evolution and reduction reactions(OER/ORR).Yet the key mechani...Graphitic carbon nitride(g-C3N4)doped with 3d transition metals(3d-TM@g-C3N4)has gained attention as a noble metal-free alternative for oxygen evolution and reduction reactions(OER/ORR).Yet the key mechanisms driving its performance remain debated,especially across different charge states.In this study,we investigate the electrocatalytic performance of 3d-TM@gC3N4(TM=V,Cr,Mn,Fe,Co,Ni,and Cu)in different charge states using a defect physics method based on density functional theory(DFT).We find that 33 unique charge states of 3d-TM@g-C3N4 are thermodynamically stable.Among them,the Cosubstituted nitrogen site in the+1 charge state(CoN1+@C54N71,ηOER/ηORR=0.57/0.50 V)and the Ni interstitial site in the+1 charge state(Niint1+@C54N72,ηOER/ηORR=0.43/0.35 V)exhibit lower overpotentials(η).Beyond the choice of dopant,key factors influencing the OER/ORR activity of 3d-TM@C3N4 include formation energy,charge state,and the Fermi level of the defective system.Furthermore,machine learning results reveal that the first ionization energy and the atomic radius of TMs are critical descriptors for predictingηOER andηORR,respectively.Constant-potential DFT calculations further confirm that CoN@C54N71 and Niint@C54N72 exhibit excellent bifunctional activity at pH=0 and U=0 V versus RHE,with ηOER/ηORR values of 0.71/0.57 V and 0.72/0.56 V,respectively—demonstrating strong potential for experimental synthesis.The study proposes a new category of bifunctional oxygen catalysts and introduces an innovative approach to optimize their electrocatalytic performance by engineering charge states and electronic structures.展开更多
This research focuses on the theory of harmonic univalent functions,a significant branch of complex analysis.The primary objective of this paper is to introduce a novel convolution operator incorporating the Rabotnov ...This research focuses on the theory of harmonic univalent functions,a significant branch of complex analysis.The primary objective of this paper is to introduce a novel convolution operator incorporating the Rabotnov function and to utilize it to investigate the relationships between various subfamilies of harmonic functions defined in the open unit disk.The Rabotnov fractional exponential function,which serves as a generalization of the Mittag-Leffler function,is a crucial tool in mathematical modeling for material sciences,particularly in viscoelasticity.By applying a specific normalization to the Rabotnov function to obtain RK;(z),we define a new linear operator F that acts on the analytic and co-analytic parts of harmonic mappings.The study establishes precise conditions under which the operator F maps functions from the classes of harmonic starlike functions SH*;0 H and harmonic convex functions K0H into the general class WH(γ;α;Φ).These findings are derived through rigorous coefficient inequality analysis and the application of fundamental lemmas regarding harmonic mappings.Furthermore,the paper provides several illuminating corollaries and illustrative examples to demonstrate the geometric implications of the results.展开更多
Metals enhance the cooling efficiency of molecular clouds,promoting fragmentation.Consequently,increasing the metallicity may boost the formation of low-mass stars.Within the integrated galactic initial mass function(...Metals enhance the cooling efficiency of molecular clouds,promoting fragmentation.Consequently,increasing the metallicity may boost the formation of low-mass stars.Within the integrated galactic initial mass function(IGIMF)theory,this effect is empirically captured by a linear relation between the slope of the low-mass stellar IMF,α_1,and the metal mass fraction,Z.This linearα_1-Z relation has been calibrated up to≈2Z_☉,though higher metallicity environments are known to exist.We show that if the linearα_1-Z relation extends to higher metallicities([Z]■0.5),massive star formation is suppressed entirely.Alternatively,fragmentation efficiency may saturate beyond some metallicity threshold if gravitational collapse cascades rapidly enough.To model this behavior,we propose a logistic function describing the transition from metallicity-sensitive to metallicityinsensitive fragmentation regimes.We provide a user-friendly public code,pyIGIMF,which enables the instantaneous computation of the IGIMF theory with both linear and logisticα_1-Z relations.展开更多
Functional canonical correlation analysis is a key method in multivariate statistics for identifying optimal linear correlations between two functional datasets.However,some functions within these datasets may exhibit...Functional canonical correlation analysis is a key method in multivariate statistics for identifying optimal linear correlations between two functional datasets.However,some functions within these datasets may exhibit anomalies such as sudden changes or fluctuations that deviate from the overall trend,resulting to inaccurate results.To address this,we propose an improved method:Sparse functional canonical correlation analysis based on the L2,1-norm.This approach reduces outliers by optimizing the selection of orthogonal basis functions,thereby enhancing the accuracy and reliability of the analysis.Numerical experiments show that the L2,1-norm-based method significantly outperforms traditional methods.展开更多
The concept of land use multifunctionality(LUMF)is fundamental to national spatial zoning,with its main functions evolving in response to socio-economic development.In this dynamic,maintaining alignment between the ac...The concept of land use multifunctionality(LUMF)is fundamental to national spatial zoning,with its main functions evolving in response to socio-economic development.In this dynamic,maintaining alignment between the actual and the planned main functions is essential for effective spatial planning.This study centers on Sichuan province,where the entropy weight-TOPSIS model was utilized to delineate the spatiotemporal distribution of LUMF and a mechanical equilibrium model was applied to evaluate functional coordination.This approach facilitated an examination of the congruence between the actual and planned main functions.Discrepancy was identified and subsequently excluded from the analysis.Building on this foundation,the propensity score matching–difference-in-differences(PSM-DID)model was employed to quantitatively assess the policy impacts within the matched areas.Key Findings:(1)From 2010 to 2020,the average increase in urban development functions was 10.4,with a decrease in intensity from the urban periphery outward;ecological conservation functions experienced an increase of 1.53,while agricultural functions exhibited a slight decline.(2)Overall,functional coordination showed improvement across 80.32%of the studied areas.However,coordination diminished in key development areas,whereas it was strengthened in agricultural and ecological areas.(3)In 28 counties,a divergence between planned and actual functions was observed,primarily characterized by a focus on agricultural production in key development areas.(4)The planning processes bolstered urban development and ecological conservation functions but exerted limited influence on the major agricultural production areas.The findings provide empirical support for spatial coordination,land allocation,and policy development.展开更多
Graphitic carbon nitride(g-CN)stands out as the most promising candidate for solar energy conversion owing to its easy preparation,metal-free nature,flexible molecular structure,moderate bandgap,and excellent thermal/...Graphitic carbon nitride(g-CN)stands out as the most promising candidate for solar energy conversion owing to its easy preparation,metal-free nature,flexible molecular structure,moderate bandgap,and excellent thermal/chemical stability.To enhance the performance of intrinsic g-CN,a supramolecular self-assembly strategy has been proposed to regulate the molecular structure of supramolecular precursors through non-covalent interactions across molecular building blocks,thereby optimizing the electronic structure of g-CN.This review provides a comprehensive overview of the recent progress in supramolecular self-assembly-derived graphitic carbon nitride(SM-CN)from both experimental and theoretical computational research in synthesis strategies,including synthesis methods and influencing factors,providing a theoretical foundation for the design of supramolecular assembly.It also discusses modification strategies,such as internal modification of the conjugated plane,interlayer optimization,and construction of heterointerfaces to improve the electronic structure of SM-CN owing to its unique layered structure.This review further summarizes the applications of SM-CN in environment and energy,including wastewater treatment,sterilization and disinfection/air purification,water splitting,H2O2production,organic synthesis/biomass conversion,CO2reduction,photocatalytic coupling technology.Finally,perspectives and outlooks for the future development of SM-CN aim to inspire further innovation in the design and construction of high-performance SM-CN for broader applications.展开更多
BACKGROUND Vascular endothelial dysfunction(VED)is thought to contribute to the pathogenesis of vasospastic angina(VSA),but its prognostic significance remains unclear.AIM To evaluate whether clinical characteristics ...BACKGROUND Vascular endothelial dysfunction(VED)is thought to contribute to the pathogenesis of vasospastic angina(VSA),but its prognostic significance remains unclear.AIM To evaluate whether clinical characteristics and prognosis differ according to the presence or absence of VED in patients with VSA.METHODS We retrospectively analyzed 244 patients(mean age 67 years,107 men)admitted for chest pain screening and diagnosed with VSA by spasm provocation testing.Vascular endothelial function was evaluated using brachial artery flow-mediated dilation(FMD).Patients were divided into a high-FMD group(≥3.7%;n=123)and a low-FMD group(FMD-L,<3.7%;n=121).VSA was defined as≥90%coronary vasoconstriction on angiography with chest symptoms and/or electrocardiographic changes during spasm provocation testing.Focal spasm was defined as spasm localized within a single American Heart Association coronary segment.Major adverse cardiovascular events included cardiac death and cardiovascular rehospitalization.RESULTS Baseline characteristics,except for age(P=0.017),did not differ significantly between groups.Focal spasm tended to be more frequent in the FMD-L group(43%vs 32%,P=0.069).Kaplan-Meier analysis showed a significantly lower major adverse cardiovascular events-free survival rate in the FMD-L group(log-rank P=0.004).Multivariate Cox regression identified FMD-L(P=0.025)and older age(P=0.026)as independent prognostic factors,whereas focal spasm was not significant(P=0.157).CONCLUSION VED is an independent predictor of adverse outcomes in VSA.Evaluation of endothelial function may provide valuable prognostic information in patients with VSA.展开更多
A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synth...A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synthetic metabolic engineering offers a method to modify and redesign metabolic pathways to increase the nutritional value of crops.We summarize recent advances in the biofortification of key nutrients including provitamin A,vitamin C,vitamin B9,iron,zinc,anthocyanins,flavonoids,and unsaturated fatty acids.We discuss the potential of multi-gene stacking,gene editing,enzyme engineering,and artificial intelligence in synthetic metabolic engineering.We propose future research directions and potential solutions centered on leveraging AI-driven systems biology,precision gene editing,enzyme engineering,agrobacterium-mediated genotype-independent transformation,and modular metabolic engineering strategies to develop next-generation nutritionally enhanced super crops and transform global food systems.展开更多
Shale gas development often suffers from wellbore instability due to microfractures in the formation,posing serious challenges to drilling safety and efficiency.This study presents a functionalized graphene oxide(GO-P...Shale gas development often suffers from wellbore instability due to microfractures in the formation,posing serious challenges to drilling safety and efficiency.This study presents a functionalized graphene oxide(GO-PAA)nanomaterial,prepared by grafting hydrophilic polyacrylic acid(PAA)chains onto GO surfaces to enhance dispersion stability under high salinity,elevated temperature,and wide pH conditions.The results indicate that GO-PAA effectively resists charge-shielding effects under conditions of high salinity,elevated temperature,and a wide pH range,significantly reducing the risk of particle aggregation.Even at high salt concentrations,the zeta potential remains below-32.8 mV,demonstrating good colloidal stability.Plugging performance was evaluated using simulated core experiments.GO-PAA fo rmed a"band-aid"like barrier on shale microfracture surfaces,reducing permeability by up to57.53%,nearly twice that of conventional spherical nano particles.Scanning electron microscope(SEM)and elemental analysis confirmed the formation of a dense and uniform plugging layer.The synergistic interaction between GO's 2D lamellar structure and the flexible polymer chains facilitated effective surface adhesion and coverage.This adsorption-adhesion plugging mechanism represents a shift from traditional bridging theories,enabling reduced material usage and improved efficiency.The findings provide theo retical and practical support for designing high-perfo rmance nanoplugging agents in waterbased drilling fluids,contributing to safer and more sustainable shale gas development.展开更多
Ln@MOFs by anchoring rare metal ions(Ln) into metal-organic frameworks(MOFs) are proved to have great potential in the field of luminescent molecular thermometer.Nevertheless,the current research indicated that the po...Ln@MOFs by anchoring rare metal ions(Ln) into metal-organic frameworks(MOFs) are proved to have great potential in the field of luminescent molecular thermometer.Nevertheless,the current research indicated that the poor structural stability and low sensitivity hindered their application scope.In this work,a new MOF Zn-450 luminescent thermometer with multiple emission fluorescence characteristics was synthesized by the combination of 3,3,5,5-biphenyl tetracarboxylic acid(H4L) and Zn2+ ion under solvothermal conditions.Interestingly,a high relative sensitivity of 1.43 % K-1 was found within 80-300 K based on Zn-450.Subsequently,two high-sensitivity luminescent Ln@MOFs(Ln = Eu and Tb) were further fabricated by doping rare earth ions into Zn-450 based on the post-synthesis strategy.Among them,the Eu@Zn-450 demonstrates various luminous behaviors while achieving an increased relative sensitivity of 1.63 % K-1.In addition,the continuously visible red,pink,and purple luminescent emissions at the same temperature range were observed,suggesting that the Eu@Zn-450 could be utilized as a luminescent colorimetric molecular thermometer.Importantly,this work can present new possibilities for the development of rare earth-doped luminescence and its temperature sensing properties.展开更多
基金partially supported by the Center for Advanced Systems Understanding (CASUS), financed by Germany’s Federal Ministry of Education and Research and the Saxon State Government out of the State Budget approved by the Saxon State Parliamentthe European Union’s Just Transition Fund (JTF) within the project Röntgenlaser Optimierung der Laserfusion (ROLF), Contract No. 5086999001, co-financed by the Saxon State Government out of the State Budget approved by the Saxon State Parliament+3 种基金the European Research Council (ERC) under the European Union’s Horizon 2022 Research and Innovation Programme (Grant Agreement No. 101076233, “PREXTREME”)Computations were performed on a Bull Cluster at the Center for Information Services and High-Performance Computing (ZIH) at Technische Universität Dresden and at the Norddeutscher Verbund für Hoch- und Höchstleistungsrechnen (HLRN) under Grant No. mvp00024support by the National Natural Science Foundation of China under Grant No. 12274171support by the Advanced Materials–National Science and Technology Major Project (Grant No. 2024ZD0606900)
摘要Understanding the properties of warm dense hydrogen is of key importance for the modeling of compact astrophysical objects and to understand and further optimize inertial confinement fusion applications.The workhorse of warm dense matter theory is thermal density functional theory(DFT),which,however,suffers from two limitations:(i)its accuracy can depend on the utilized exchange-correlation functional,which has to be approximated,and(ii)it is generally limited to single-electron properties such as the density distribution.Here,we present a new ansatz combining time-dependent DFT results for the dynamic structure factor See(q,ω)with static DFT results for the density response.This allows us to estimate the electron-electron static structure factor See(q)of warm dense hydrogen with high accuracy over a broad range of densities and temperatures.In addition to its value for the study of warm dense matter,our work opens up new avenues for the future study of electronic correlations exclusively within the framework of DFT for a host of applications.
摘要BACKGROUND Schizophrenia presents complex challenges in older patients due to cognitive and social decline.Existing drug treatments offer limited benefits and pose risks,while aerobic exercise shows promise as a noninvasive intervention whose impact remains underexplored.AIM To investigate the effects of aerobic exercise on cognitive and social function in older patients with schizophrenia.METHODS A retrospective study was conducted in 158 older patients with schizophrenia treated at The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College(June 2023 and December 2024).The patients were divided into an observation group(n=86),which received 3 months of aerobic rehabilitation alongside routine treatment,and a control group(n=72),which received routine treatment alone.Cognitive function was assessed using the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery,social function using the Inpatient Psychiatric Rehabilitation Outcome Scale(IPROS),and psychotic symptoms using the Positive and Negative Syndrome Scale.RESULTS Post-treatment,Positive and Negative Syndrome Scale total scores were lower in the observation group than in the controls(P<0.001),with significant improvements in positive,negative,and general symptoms.Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery domain scores were improved in processing speed,working memory,verbal/visual learning,and executive function(all P<0.05).IPROS total scores were decreased(P<0.001),indicating better social functioning.Longer exercise duration correlated with greater cognitive gains and lower social function deficits.Body mass index declined(P<0.001),and adverse events were mild and transient(9.3%).Multivariate linear regression confirmed that aerobic exercise was independently associated with a significant reduction in IPROS scores(Adjustedβ=-4.57,95%confidence intervals:-6.08 to-3.05,P<0.001).CONCLUSION Aerobic exercise effectively improves cognitive function,social function,and psychotic symptoms in older patients with schizophrenia,is safe,and serves as a valuable adjunctive intervention.
基金supported by National High Level Hospital Clinical Research Funding,grant nos.BJ-2025-122,BJ2023-126CAMS Innovation Fund for Medical Sciences(CIFMS),grant no.2021-I2M-1050National Natural Science Foundation of China,grant no.82170956。
摘要Chronic obstructive pulmonary disease(COPD),a disease responsible for early mortality worldwide,is well accepted to be associated with periodontitis epidemiologically.Although both of the diseases are the multi-microbial inflammatory disease,the precise underlying mechanisms by which periodontitis influences the progression of COPD remains largely unknown.Here,we established COPD accompanied with periodontitis mouse models and observed the pronounced progress in pulmonary symptoms and histopathology,cha racterized by poorer respiratory function,thicke ned bronchial walls,and increased neutrophils infiltration in lung tissue.Mechanistically,periodontitis pathogen Porphyromonas gingivalis(P.gingivalis)relocated in the lung through the respiratory tract and LPS from P.gingivalis promoted the secretion of chemokines CXCL2 and G-CSF of alveolar epithelial cells through NF-κB and p38 MAPK pathways to recruit neutrophils.Furthermore,exposure to P.gingivalis of infiltrated neutrophils released matrix metallopeptidase-8(MMP-8)and neutrophil elastase(NE),which aggravated airway inflammation and tissue damage.These findings indicated that periodontitis could exacerbate COPD via its pathogen P.gingivalis,which translocated in the lung and stimulated neutrophil chemotaxis and activation in the lung.
基金supported by the National Natural Science Foundation of China,Nos.82201474(to GL),82203835(to YF),82071330(to ZT)。
摘要Functional near-infrared spectroscopy quantifies cerebral hemodynamic signals by capturing oxygenation-dependent changes in hemoglobin in a noninvasive,portable,and ecologically valid manner,providing a unique insight into neurovascular coupling.However,functional imaging biomarkers with high ecological validity for neurological disorders such as stroke,Parkinson's disease,dementia,amyotrophic lateral sclerosis,epilepsy,spinal cord injury,and traumatic brain injury are lacking,limiting the mechanistic understanding,treatment evaluations,and individualized interventions.The aim of this review is to systematically summarize evidence from the past decade on the use of functional near-infrared spectroscopy under the aforementioned conditions,synthesize its value for revealing neural mechanisms and assessing therapeutic responses,and identify current technical bottlenecks and future directions for advancement.Collectively,the findings demonstrate that functional near-infrared spectroscopy possesses substantial and far-reaching potential for uncovering the neural mechanisms underlying disease and for evaluating treatment-induced changes in brain function.Equipped with wearable probes,functional near-infrared spectroscopy can continuously and noninvasively monitor brain activity in naturalistic environments for extended periods,thereby overcoming the limitations of conventional imaging modalities that can only acquire data under restricted settings.This capability can furnish unprecedented objective neuroimaging evidence for neuroregenerative therapy research.Moreover,the portability of functional near-infrared spectroscopy allows it to be integrated into neurofeedback training systems:hemoglobin signals can be fed back to participants within milliseconds,enabling targeted,individualized,closed-loop modulation of brain function and considerably expanding the scope of hemodynamicsbased neurofeedback.When combined with other brain function assays(such as electroencephalography)and intervention techniques(such as transcranial magnetic stimulation and transcranial direct current stimulation),functional near-infrared spectroscopy also supplies high-temporal-resolution hemodynamic information,laying a critical foundation for the construction of high-precision noninvasive brain–computer interfaces,real-time cognitivestate decoding,and adaptive neuromodulation.Admittedly,almost all existing functional near-infrared spectroscopy studies are still observational and have small sample sizes,short follow-ups,and insufficient controls—shortcomings that together produce low-grade evidence.Therefore,there is still a significant gap before clinical translation can be achieved.Technically,the limited penetration depth of functional near-infrared spectroscopy restricts sampling to the superficial cortex,leaving deep nuclei largely unreachable.In addition,no consensus exists across devices regarding optode layout,light-source choice,motion-artifact correction,or analytical pipelines,creating pronounced heterogeneity that undermines reproducibility.With artificial intelligence and big data analytics advancing rapidly,functional near-infrared spectroscopy embedded within multimodal fusion frameworks is now poised to systematically map aberrant brain function signatures of neurological disorders,identify pathological regions suitable for targeted intervention,and provide real-time assessments of functional changes produced by neuroregenerative therapies.
基金Supported by the Affiliated Hospital of North Sichuan Medical College,No.2020ZD017 and No.2020ZD008.
摘要BACKGROUND Cognitive impairment is a common functional impairment after stroke that severely affects the quality of life of patients.The underlying neurobiological mechanisms of poststroke cognitive impairment(PSCI)remain unclear.AIM To investigate the changes in functional connectivity(FC)in the brains of patients with PSCI.METHODS A total of 21 patients with PSCI and 12 healthy controls were selected as study subjects,and resting-state functional magnetic resonance imaging was performed.The brain region[Cerebellum_6_R(aal)]with significant differences identified by regional homogeneity analysis and the left thalamus,right thalamus,left basal ganglia,and right basal ganglia in the Brainnetome Atlas were selected as the seeds(regions of interest),and the FC between the seeds and whole-brain voxels was analyzed.Moreover,the 116 brain regions defined in the AAL116 atlas were selected as seeds(regions of interest),and the FC between the whole-brain seeds was calculated.RESULTS The results of the seed-based FC analysis revealed that the FC of the Cerebelum_9_R,Occipital_Mid_L,and Fusiform_R in the PSCI group was significantly greater than that in the control group.FC analysis of whole-brain seeds revealed that the FC of 20 pairs(Cerebelum_4_5_R and Cerebelum_6_R,etc.)in the PSCI group was significantly greater than that in the healthy control group.CONCLUSION Patients with PSCI exhibit changes in the FC of specific brain regions in the resting state,which may help researchers explore the underlying neurobiological mechanisms of PSCI from a new perspective.
基金supported by the NSFC(11561001)the Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(NJYT18-A14)+4 种基金the NSF of Inner Mongolia(2022MS01004,2020MS01011)the Higher School Foundation of Inner Mongolia(NJZY20200)the Program for Key Laboratory Construction of Chifeng University(CFXYZD202004)the Research and Innovation Team of Complex Analysis and Nonlinear Dynamic Systems of Chifeng University(cfxykycxtd202005)the Youth Science Foundation of Chifeng University(cfxyqn202133).
摘要In recent years,researchers have extensively investigated the Hankel determinant,which consists of coefficients appearing in a holomorphic function’s Taylor-Maclaurin series.Hankel matrices are widely used in Markov processes,non-stationary signals,and other mathematical disciplines.The aim of the current research article is to first improve the bounds of coefficient-related problems by employing the well-known Carathéodory function.The problems that we are going to improve were obtained by Tang et al.The sharp estimates of the most difficult problem of geometric function theory known as the third-order Hankel determinant are also contributed here.Zalcman and Fekete-Szegöinequalities are also studied here for the defined family of holomorphic functions.
基金supported by the National Natural Science Foundation of China(82370935,81870802)Sichuan Province Science and Technology Support Program Grant(2023YFS0244)+3 种基金Sichuan Science andTechnology Program(2025ZNSFSC0768)Clinical Research Project Funded by West China Hospital of StomatologySichuan University(LCYJ-MS-202302)The Key Research and Development Support Program of the Chengdu Scienceand Technology Bureau(2024-YF05-00505-SN)Research Project on Graduate Education and Teaching Reform ofSichuan University(GSSCU2024105).
摘要Objectives:Mitochondrial function is intricately linked to osteogenic and osteoclastic differentiation.The mitochondrial calcium uniporter(MCU)is a critical regulator of mitochondrial function,influencing key aspects of cellular metabolism and signaling.However,the precise mechanisms by which MCU modulates osteogenic activity remain unclear.This study aimed to elucidate the impact of MCU-mediated regulation of mitochondrial function on bone remodeling and to explore the underlying mechanisms.Methods:The mouse pre-osteoblastic cells(MC3T3-E1)were treated with the MCU-specific inhibitor Ru265 during osteogenic induction to assess changes in osteogenic differentiation capacity,mitochondrial function,and mitochondrial dynamics.Additionally,MCU global knockout(MCU KO)mice were employed as an in vivo model to explore the role of MCU in bone structure phenotype through bone microstructural analysis and histological examination.Results:Quantitative reverse transcription(qRT)PCR,western blotting,alizarin Red-S(ARS)staining,and alkaline phosphatase(ALP)activity analyses revealed that the inhibition of MCU function by Ru265 downregulates ALP activity(about 59.60%of the control group)and the expression of osteogenic markers in MC3T3-E1 cells.Dramatically increased dynamin-related protein 1(Drp1)expression(about 1.13 times of the control group),decreased mitofusion-2(Mfn2)expression(about 14.51%of the control group),and reduced mitochondrial membrane potential(MMP)(about 55.16%of the control group)were observed,all indicating substantial disruption of mitochondrial dynamics and function in MC3T3-E1 cells.The corroborating evidence is thatμCT and histological analyses of MCU global knockout mice revealed impaired osteogenic differentiation,reduced bone mass formation,and deteriorated trabecular bone microstructure compared with wild-type mice.Conclusion:MCU inhibition elicits aberrant mitochondrial dynamics and mitochondrial dysfunction,thereby impairing osteogenic function and disrupting bone remodeling,which could have promising implications for bone metabolism.
基金supported by the National Natural Science Foundation of China(No.42201323)the National Key Research and Development Program of China(2022YFF1301204)+1 种基金Science and Technology Program of Guangzhou,China(No.2023A04J0252)the Central Public-Interest Scientific Institution Basal Research Fund of China(No.PM-zx703-202406-212,PM-zx703-202406-172).
摘要This study proposes a novel method for introducing the concept of umbrella species to identify umbrella ecological functions(UEF).The umbrella ecological function safeguards broader ecological functions within its spatial extent by protecting a single function.This approach transforms the originally complex ecological function conservation plan into a more specific conservation target,thereby simplifying the conservation process and enhancing conserva-tion practices.Subsequently,this study formulates the ecological function zoning of the Guangdong-Hong Kong-Macao Greater Bay Area of China(GBA)based on the UEF,aiming to provide recommendations for ensuring regional ecological security.The findings reveal that habitat quality(HQ)possesses the highest umbrella value and is therefore deemed suitable as the UEF in the GBA.The ecological function zoning comprises three types of zones:priority conser-vation zone,other conservation zone,and ordinary zone.A critical aspect of protecting the UEF is to limit the encroach-ment of natural ecosystems due to land use changes driven by urbanization.The UEF-based ecological function zoning method established in this study is both universal and widely applicable.However,certain limitations exist.Different UEFs may emerge when the spatial scale of the study object varies.This study posits that the UEF evaluation method is more suitable for applications at a smaller spatial scale,particularly in areas with similar natural environments or geo-graphic conditions.For practical applications,it is recommended that the study area be confined to a smaller spatial scale,such as a county or city.
基金National Natural Science Foundation of China(General Program):Mechanism of Electroacupuncture Regulating Mouse Double Minute 2 Ubiquitination of Postsynaptic Density protein-95 to Remodel Hippocampal Synaptic Structure and Improve Cognitive Dysfunction in Chronic Fatigue Syndrome(No.82074539)National Natural Science Foundation of China(Young Scientists Program):Role and Mechanism of Nuclear Factor Kappa B in Electroacupuncture Against Chronic Fatigue Syndrome Based on the Transforming Growth Factor-beta/Smad Signaling Pathway(No.81704170)+8 种基金Natural Science Foundation of Heilongjiang Province(General Program):Mechanism of Electroacupuncture Regulating Mitochondrial Dynamics to Promote Synaptic Remodeling in Chronic Fatigue Syndrome Rats with Cognitive Impairment(No.LH2024H050)Heilongjiang Province Postdoctoral Research Funding Program:Mechanism of Electroacupuncture Regulating p-T19 Postsynaptic Density protein-95 and Modulating Mitophagy in Synaptic Reconstruction to Improve Cognitive Impairment in Chronic Fatigue Syndrome Rats(No.LBH-Z24291)National Natural Science Foundation Cultivation Support Program(Young Scientists)of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine:Mechanism of Electroacupuncture Intervention in the Butyrate Gut-brain Axis Affecting p-T19 Postsynaptic Density Protein 95 to Promote Autophagy and Improve Cognitive Impairment in Chronic Fatigue Syndrome Rats(No.PYQN202501002)National Natural Science Foundation of China(Young Scientists Program):Mechanism of Moxibustion Activating Calcium-calmodulin-dependent Protein Kinase II Phosphorylation-mediated Long-term Potentiation to Regulate Synaptic Plasticity in Treating Chronic Fatigue Syndrome Cognitive Impairment(No.82305394)Ministry of Education“Chunhui Program”Collaborative Research Project:Mechanism of the“Tongdu Yupi Tiaoshen”Acupuncture Technique in Improving Hippocampal Synaptic Plasticity in Chronic Fatigue Syndrome Cognitive Dysfunction(No.HZKY20220308-202201357)Heilongjiang Provincial Traditional Chinese Medicine Research Project:Mechanism of Electroacupuncture in Regulating Hippocampal Synaptic Plasticity in Chronic Fatigue Syndrome Rats with Cognitive Dysfunction(No.ZHY2022-136)China Association of Chinese Medicine:Chinese Medicine Young Talent Support Project(No.CACM-2023-QNRC2-A04)Heilongjiang Provincial Association of Chinese Medicine Young Talent Support Project(2022-2024):Mechanism of the“Tongdu Yupi Tiaoshen”Acupuncture Technique in Improving Hippocampal Synaptic Plasticity in Chronic Fatigue Syndrome Cognitive Dysfunction(No.2022-QNRC1-05)Heilongjiang Provincial Key Research and Development Program Project(Directed Commission):Development of a Central-peripheral closed-loop Regulation Rehabilitation Robot for Post-stroke Cognitive Impairment Based on Traditional Chinese Medicine Acupuncture Theory(No.2024ZXDXC50)。
摘要OBJECTIVE:To investigate the effects of electroacupuncture intervention on behavioral performance,hippocampal structure,and function in chronic fatigue syndrome(CFS)rats and to explore the underlying mechanisms.METHODS:Specific pathogen free-grade male SpragueDawley rats were randomly allocated into a control group(Con group,n=12)and a modeling group.The latter underwent a 21-d CFS induction via an improved chronic multi-factor compound stress stimulation protocol.Successfully modeled CFS rats were then randomly assigned to a model group(Mod group,n=12)and an electroacupuncture group(EA group,n=12).During the 14-d treatment period,both the Mod and EA groups continued to receive chronic stress stimuli.Rats in the EA group received electroacupuncture at Shenting(GV24)through to Baihui(GV20),with additional stimulation on Dazhui(GV14).Each session lasted 15 min,administered twice daily with a 6-h interval between morning and afternoon treatments.After modeling and treatment,the general semi-quantitative score(GSQS)was used to evaluate the rats'general health,while the Morris water maze test(MWMT),open field test(OFT),and exhaustive treadmill test(ETT)were applied to assess their learning/memory,emotional state,and fatigue levels,respectively(n=12 per group).After the treatment phase,cerebral glucose metabolism was assessed by 1fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)imaging(n=3 per group),while hippocampal cornu ammonis 1(CA1)morphology was examined using hematoxylin-eosin(HE)and Nissl staining(n=3 per group).RESULTS:Behavioral assessments demonstrated that electroacupuncture intervention significantly improved rat performance as measured by GSQS,MWMT,OFT,and Exhaustive Treadmill Test.Both HE and Nissl staining results confirmed that,compared with the blank control group,the model group exhibited abnormal cellular morphology,disorganized arrangement,and reduced Nissl bodies in the hippocampal CA1 region.These pathological alterations were ameliorated in the electroacupuncture group relative to the model group.18F-FDG PET/CT imaging revealed that following treatment,the mean and maximum standardized uptake values(SUV)in the anterior-dorsal and posterior hippocampus were significantly decreased in the Mod group compared to the Con group.In contrast,electroacupuncture treatment significantly increased both SUV-mean and SUV-max in these hippocampal subregions in the EA group relative to the Mod group(all P<0.05).CONCLUSION:Electroacupuncture intervention alleviated cognitive impairment,hippocampal pathological structural changes,and glucose metabolism dysfunction in a rat model of chronic fatigue syndrome induced by an improved chronic multi-factor compound stress stimulation method.
基金supported by China Scholarship Council,No.202306100073(to LY)UniBern Forschungsstiftung,No.31/2025(to RN)。
摘要Alzheimer's disease(AD),the most common cause of dementia,is a progressive neurodegenerative disease characterized by progressive cognitive decline and memory loss.Mild cognitive impairment(MCI)is the prodromal stage of AD,with a conversion rate of 10%-15%per year and 50%conversion rate longitudinally.The pathological features of AD include the aberrant accumulation of amyloid-βplaques,neurofibrillary tangles formed by hyperphosphorylated tau and synaptic dysfunction(Nussbaumer et al.,2025),all of which have cascading effects on the brain activity of AD patients.
基金supported by the National Natural Science Foundation of China(Grant No.52262031)Guizhou Provincial Basic Research Program(Natural Science)(Grant No.QKHJC‐ZK[2023]YB284)+2 种基金the Key Scientific Research Projects of Colleges and Universities Henan Province(Grant No.24A140001)the Young Scientist Project of Henan Province(Grant No.225200810103)the Natural Science Foundation of Henan(Grant No.252300420363).
摘要Graphitic carbon nitride(g-C3N4)doped with 3d transition metals(3d-TM@g-C3N4)has gained attention as a noble metal-free alternative for oxygen evolution and reduction reactions(OER/ORR).Yet the key mechanisms driving its performance remain debated,especially across different charge states.In this study,we investigate the electrocatalytic performance of 3d-TM@gC3N4(TM=V,Cr,Mn,Fe,Co,Ni,and Cu)in different charge states using a defect physics method based on density functional theory(DFT).We find that 33 unique charge states of 3d-TM@g-C3N4 are thermodynamically stable.Among them,the Cosubstituted nitrogen site in the+1 charge state(CoN1+@C54N71,ηOER/ηORR=0.57/0.50 V)and the Ni interstitial site in the+1 charge state(Niint1+@C54N72,ηOER/ηORR=0.43/0.35 V)exhibit lower overpotentials(η).Beyond the choice of dopant,key factors influencing the OER/ORR activity of 3d-TM@C3N4 include formation energy,charge state,and the Fermi level of the defective system.Furthermore,machine learning results reveal that the first ionization energy and the atomic radius of TMs are critical descriptors for predictingηOER andηORR,respectively.Constant-potential DFT calculations further confirm that CoN@C54N71 and Niint@C54N72 exhibit excellent bifunctional activity at pH=0 and U=0 V versus RHE,with ηOER/ηORR values of 0.71/0.57 V and 0.72/0.56 V,respectively—demonstrating strong potential for experimental synthesis.The study proposes a new category of bifunctional oxygen catalysts and introduces an innovative approach to optimize their electrocatalytic performance by engineering charge states and electronic structures.
摘要This research focuses on the theory of harmonic univalent functions,a significant branch of complex analysis.The primary objective of this paper is to introduce a novel convolution operator incorporating the Rabotnov function and to utilize it to investigate the relationships between various subfamilies of harmonic functions defined in the open unit disk.The Rabotnov fractional exponential function,which serves as a generalization of the Mittag-Leffler function,is a crucial tool in mathematical modeling for material sciences,particularly in viscoelasticity.By applying a specific normalization to the Rabotnov function to obtain RK;(z),we define a new linear operator F that acts on the analytic and co-analytic parts of harmonic mappings.The study establishes precise conditions under which the operator F maps functions from the classes of harmonic starlike functions SH*;0 H and harmonic convex functions K0H into the general class WH(γ;α;Φ).These findings are derived through rigorous coefficient inequality analysis and the application of fundamental lemmas regarding harmonic mappings.Furthermore,the paper provides several illuminating corollaries and illustrative examples to demonstrate the geometric implications of the results.
基金support of the National Natural Science Foundation of China(NSFC,grant Nos.1251101411,12041305,12173016,1257030642,12533003,and 12203021)science research grants from the China Manned Space Project with NOs.CMS-CSST-2021-A08(IMF),CMS-CSST-2021-A07+5 种基金Program for Innovative TalentsEntrepreneur in Jiangsusupported by the Fundamental Research Funds for the Central Universities,No.KG202502support from the Jiangsu Funding Program for Excellent Postdoctoral Talent under grant No.2022ZB54the Fundamental Research Funds for the Central Universities under grant No.0201/14380049support through the DAAD-Eastern-European Exchange program between Bonn and Prague。
摘要Metals enhance the cooling efficiency of molecular clouds,promoting fragmentation.Consequently,increasing the metallicity may boost the formation of low-mass stars.Within the integrated galactic initial mass function(IGIMF)theory,this effect is empirically captured by a linear relation between the slope of the low-mass stellar IMF,α_1,and the metal mass fraction,Z.This linearα_1-Z relation has been calibrated up to≈2Z_☉,though higher metallicity environments are known to exist.We show that if the linearα_1-Z relation extends to higher metallicities([Z]■0.5),massive star formation is suppressed entirely.Alternatively,fragmentation efficiency may saturate beyond some metallicity threshold if gravitational collapse cascades rapidly enough.To model this behavior,we propose a logistic function describing the transition from metallicity-sensitive to metallicityinsensitive fragmentation regimes.We provide a user-friendly public code,pyIGIMF,which enables the instantaneous computation of the IGIMF theory with both linear and logisticα_1-Z relations.
基金The National Natural Science Foundation of China “Optimization models and algorithms for interpretable learning machines on complex data”(12461058)Xinjiang Key Laboratory of Applied Mathematics (XJDX1401)。
摘要Functional canonical correlation analysis is a key method in multivariate statistics for identifying optimal linear correlations between two functional datasets.However,some functions within these datasets may exhibit anomalies such as sudden changes or fluctuations that deviate from the overall trend,resulting to inaccurate results.To address this,we propose an improved method:Sparse functional canonical correlation analysis based on the L2,1-norm.This approach reduces outliers by optimizing the selection of orthogonal basis functions,thereby enhancing the accuracy and reliability of the analysis.Numerical experiments show that the L2,1-norm-based method significantly outperforms traditional methods.
基金The Sichuan Science and Technology Program,No.2022JDJQ0015Major Research and Development and Achievement Transformation Projects of Qinghai,China,No.2022-QY-224National Natural Science Foundation of China,No.42471225。
摘要The concept of land use multifunctionality(LUMF)is fundamental to national spatial zoning,with its main functions evolving in response to socio-economic development.In this dynamic,maintaining alignment between the actual and the planned main functions is essential for effective spatial planning.This study centers on Sichuan province,where the entropy weight-TOPSIS model was utilized to delineate the spatiotemporal distribution of LUMF and a mechanical equilibrium model was applied to evaluate functional coordination.This approach facilitated an examination of the congruence between the actual and planned main functions.Discrepancy was identified and subsequently excluded from the analysis.Building on this foundation,the propensity score matching–difference-in-differences(PSM-DID)model was employed to quantitatively assess the policy impacts within the matched areas.Key Findings:(1)From 2010 to 2020,the average increase in urban development functions was 10.4,with a decrease in intensity from the urban periphery outward;ecological conservation functions experienced an increase of 1.53,while agricultural functions exhibited a slight decline.(2)Overall,functional coordination showed improvement across 80.32%of the studied areas.However,coordination diminished in key development areas,whereas it was strengthened in agricultural and ecological areas.(3)In 28 counties,a divergence between planned and actual functions was observed,primarily characterized by a focus on agricultural production in key development areas.(4)The planning processes bolstered urban development and ecological conservation functions but exerted limited influence on the major agricultural production areas.The findings provide empirical support for spatial coordination,land allocation,and policy development.
基金supported by the National Natural Science Foundation of China(NSFC No.52271228)the Natural Science Foundation of Shaanxi Province(No.2023-JC-ZD-21)the Doctoral Dissertation Innovation Fund of Xi'an University of Technology(No.101-252072301)。
摘要Graphitic carbon nitride(g-CN)stands out as the most promising candidate for solar energy conversion owing to its easy preparation,metal-free nature,flexible molecular structure,moderate bandgap,and excellent thermal/chemical stability.To enhance the performance of intrinsic g-CN,a supramolecular self-assembly strategy has been proposed to regulate the molecular structure of supramolecular precursors through non-covalent interactions across molecular building blocks,thereby optimizing the electronic structure of g-CN.This review provides a comprehensive overview of the recent progress in supramolecular self-assembly-derived graphitic carbon nitride(SM-CN)from both experimental and theoretical computational research in synthesis strategies,including synthesis methods and influencing factors,providing a theoretical foundation for the design of supramolecular assembly.It also discusses modification strategies,such as internal modification of the conjugated plane,interlayer optimization,and construction of heterointerfaces to improve the electronic structure of SM-CN owing to its unique layered structure.This review further summarizes the applications of SM-CN in environment and energy,including wastewater treatment,sterilization and disinfection/air purification,water splitting,H2O2production,organic synthesis/biomass conversion,CO2reduction,photocatalytic coupling technology.Finally,perspectives and outlooks for the future development of SM-CN aim to inspire further innovation in the design and construction of high-performance SM-CN for broader applications.
摘要BACKGROUND Vascular endothelial dysfunction(VED)is thought to contribute to the pathogenesis of vasospastic angina(VSA),but its prognostic significance remains unclear.AIM To evaluate whether clinical characteristics and prognosis differ according to the presence or absence of VED in patients with VSA.METHODS We retrospectively analyzed 244 patients(mean age 67 years,107 men)admitted for chest pain screening and diagnosed with VSA by spasm provocation testing.Vascular endothelial function was evaluated using brachial artery flow-mediated dilation(FMD).Patients were divided into a high-FMD group(≥3.7%;n=123)and a low-FMD group(FMD-L,<3.7%;n=121).VSA was defined as≥90%coronary vasoconstriction on angiography with chest symptoms and/or electrocardiographic changes during spasm provocation testing.Focal spasm was defined as spasm localized within a single American Heart Association coronary segment.Major adverse cardiovascular events included cardiac death and cardiovascular rehospitalization.RESULTS Baseline characteristics,except for age(P=0.017),did not differ significantly between groups.Focal spasm tended to be more frequent in the FMD-L group(43%vs 32%,P=0.069).Kaplan-Meier analysis showed a significantly lower major adverse cardiovascular events-free survival rate in the FMD-L group(log-rank P=0.004).Multivariate Cox regression identified FMD-L(P=0.025)and older age(P=0.026)as independent prognostic factors,whereas focal spasm was not significant(P=0.157).CONCLUSION VED is an independent predictor of adverse outcomes in VSA.Evaluation of endothelial function may provide valuable prognostic information in patients with VSA.
基金supported by grants from the Guangxi Science and Technology Major Project(GKAA24206023)the Biological Breeding-National Science and Technology Major Project(2024ZD04077)+2 种基金the National Natural Science Foundation of China(32272120)the National Key Research and Development Program of China(2024YFF1000800)the Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops Major Project(FCBRCE-202502,FCBRCE-202504).
摘要A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synthetic metabolic engineering offers a method to modify and redesign metabolic pathways to increase the nutritional value of crops.We summarize recent advances in the biofortification of key nutrients including provitamin A,vitamin C,vitamin B9,iron,zinc,anthocyanins,flavonoids,and unsaturated fatty acids.We discuss the potential of multi-gene stacking,gene editing,enzyme engineering,and artificial intelligence in synthetic metabolic engineering.We propose future research directions and potential solutions centered on leveraging AI-driven systems biology,precision gene editing,enzyme engineering,agrobacterium-mediated genotype-independent transformation,and modular metabolic engineering strategies to develop next-generation nutritionally enhanced super crops and transform global food systems.
基金supported by the Open Fund of State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation[PLN202413]the National Natural Science Foundation of China(52274008)+1 种基金the National Key R&D Projects(2019YFA0708303)the Science and Technology Cooperation Project of the CNPCSWPU Innovation Alliance(2020CX040102,2020CX040201)。
摘要Shale gas development often suffers from wellbore instability due to microfractures in the formation,posing serious challenges to drilling safety and efficiency.This study presents a functionalized graphene oxide(GO-PAA)nanomaterial,prepared by grafting hydrophilic polyacrylic acid(PAA)chains onto GO surfaces to enhance dispersion stability under high salinity,elevated temperature,and wide pH conditions.The results indicate that GO-PAA effectively resists charge-shielding effects under conditions of high salinity,elevated temperature,and a wide pH range,significantly reducing the risk of particle aggregation.Even at high salt concentrations,the zeta potential remains below-32.8 mV,demonstrating good colloidal stability.Plugging performance was evaluated using simulated core experiments.GO-PAA fo rmed a"band-aid"like barrier on shale microfracture surfaces,reducing permeability by up to57.53%,nearly twice that of conventional spherical nano particles.Scanning electron microscope(SEM)and elemental analysis confirmed the formation of a dense and uniform plugging layer.The synergistic interaction between GO's 2D lamellar structure and the flexible polymer chains facilitated effective surface adhesion and coverage.This adsorption-adhesion plugging mechanism represents a shift from traditional bridging theories,enabling reduced material usage and improved efficiency.The findings provide theo retical and practical support for designing high-perfo rmance nanoplugging agents in waterbased drilling fluids,contributing to safer and more sustainable shale gas development.
基金supported by the National Natural Science Foundation of China (No.21801111)the Training Plan for Young Core Teachers in Higher Education of Henan Province (No.2021GGJS131)+1 种基金Natural Science Foundation of Henan Province (No.232300421232)the Heluo Young Talent Lifting Project (No.2023HLTJ02)。
摘要Ln@MOFs by anchoring rare metal ions(Ln) into metal-organic frameworks(MOFs) are proved to have great potential in the field of luminescent molecular thermometer.Nevertheless,the current research indicated that the poor structural stability and low sensitivity hindered their application scope.In this work,a new MOF Zn-450 luminescent thermometer with multiple emission fluorescence characteristics was synthesized by the combination of 3,3,5,5-biphenyl tetracarboxylic acid(H4L) and Zn2+ ion under solvothermal conditions.Interestingly,a high relative sensitivity of 1.43 % K-1 was found within 80-300 K based on Zn-450.Subsequently,two high-sensitivity luminescent Ln@MOFs(Ln = Eu and Tb) were further fabricated by doping rare earth ions into Zn-450 based on the post-synthesis strategy.Among them,the Eu@Zn-450 demonstrates various luminous behaviors while achieving an increased relative sensitivity of 1.63 % K-1.In addition,the continuously visible red,pink,and purple luminescent emissions at the same temperature range were observed,suggesting that the Eu@Zn-450 could be utilized as a luminescent colorimetric molecular thermometer.Importantly,this work can present new possibilities for the development of rare earth-doped luminescence and its temperature sensing properties.